Podcast appearances and mentions of matthew bernstein

What should you eat on keto? A ketogenic diet shifts your body from burning carbs to burning fat and ketones, and it can be a powerful tool for supporting metabolic health as well as mental health. But knowing what to eat, what to avoid, and how to get started makes all the difference.Here, Dr. Bret Scher walks you through the essentials:The best proteins, fats, and low-carb vegetables for ketoFoods that can kick you out of ketosisA full sample day of meals with net carb countsSmart snack options and lifestyle factors that affect ketosisWhether you're new to a ketogenic diet or exploring it as part of a broader ketogenic therapy plan, the right foundation can make a significant difference in outcomes.Want to dive deeper into the specifics of a high-quality ketogenic diet? Check out our blog to learn more: Understanding the Well-Formulated Ketogenic Diet

David Baszucki - founder and CEO of Roblox - sits down with his son Matthew for the first time on a podcast together. They walk through Matthew's five-year journey with severe, treatment-resistant bipolar I disorder: the first manic episode in 2016, multiple hospitalisations, the dozens of medications, the 2017 incident in Los Angeles when David flew down on a rescue mission to find Matt homeless on the streets, and the discovery by Matthew's mother Jan of ketogenic therapy that sent Matt's symptoms into remission. David and Matthew talk about how their family journey led to the establishment of the rapidly growing field of metabolic psychiatry their family now funds, and the daily metabolic practices both father and son use today.

The Cholesterol Code documentary is challenging long-held assumptions about LDL cholesterol, ketogenic diets, and what really matters for cardiovascular risk.In this interview, Dr. Bret Scher sits down with Dr. Eric Westman, internist and low-carb researcher, to discuss the film's impact and what it could mean for the future of clinical practice.From Dave Feldman's citizen science journey to the growing body of evidence on type 2 diabetes reversal, this discussion explores why the conversation around cholesterol is finally starting to shift.You'll learn:What stood out most about The Cholesterol Code documentaryWhy elevated LDL on a ketogenic diet may not carry the risk many assumeHow citizen science is reshaping nutrition and metabolic health researchWhy type 2 diabetes reversal deserves far more clinical attention than it getsHow GLP-1 medications and lifestyle interventions can work together responsiblyWhy the future of medicine depends on diet-focused research, not just drug trialsFor physicians, patients, and anyone interested in metabolic health, this conversation captures a pivotal moment in how the medical community is beginning to rethink cardiovascular risk, ketogenic therapy, and the power of lifestyle change.

Can ketogenic therapy help atrial fibrillation? What should you make of the KETO-CTA study? And do higher ketones always mean better results?In this Metabolic Mailbag episode, Dr. Bret Scher answers audience questions about cardiovascular health, ketosis, ketone levels, and how to personalize a ketogenic approach based on your goals and metabolic health. From AFib concerns to cholesterol controversies and troubleshooting low ketone readings, this episode tackles some of the most common questions in the keto community.In this episode, we cover:Ketogenic therapy and atrial fibrillation (AFib)The latest update on the KETO-CTA studyLDL cholesterol, plaque, and cardiovascular riskWhy ketone levels don't tell the whole storyRaising ketones without sacrificing energy or muscleCarbohydrate intake and metabolic flexibilityFasting, protein, and thyroid considerationsMCT oil, exogenous ketones, and other strategies to increase ketosisOne of the biggest takeaways: context matters. Whether you're evaluating cholesterol, ketone levels, or cardiovascular risk, there is rarely a one-size-fits-all answer. Understanding your goals, metabolic health, and individual response is often more important than chasing a specific number.

Are eggs bad for you because they may raise cholesterol?It's one of the most common nutrition questions in cardiology, and one of the most misunderstood. The reality is that raising cholesterol and harming your health aren't always the same thing, and when it comes to eggs, the data tells a much more nuanced and reassuring story than most people have been led to believe.In this conversation, Dr. Bret Scher walks through the science of eggs, cholesterol, and cardiovascular risk, cutting through decades of nutritional confusion to help you understand what it actually means for your individual dietary choices.You'll learn:Why the original "eggs cause heart disease" logic doesn't hold up under scientific scrutinyWhat happens to LDL and HDL when most people eat whole eggsWho the "egg hyper responders" are and what genetics has to do with itWhy hazard ratios in observational egg studies are often clinically unhelpfulWhat the American Heart Association now says about eggs and cardiovascular riskWhy eggs are one of the most nutrient dense whole foods availableHow to think about egg quality, quantity, and individual responseThe takeaway: eggs can be part of a healthy whole foods dietary pattern for most people. Context, metabolic health, and the totality of your diet often matter far more than any single food.

Can ketogenic therapy challenge mainstream thinking on cholesterol, diabetes, and evidence-based medicine? At the CoSci conference, Dr. Ken Berry shares his reaction to The Cholesterol Code documentary and explains why more clinicians are questioning long-standing assumptions about metabolic health, LDL cholesterol, and the treatment of chronic disease.In this conversation, Dr. Berry discusses the growing tension between clinical guidelines, pharmaceutical influence, and real-world patient outcomes, while making the case for curiosity, individualized care, and the power of “citizen science” in medicine.In this episode, we cover:Dr. Ken Berry's reaction to The Cholesterol Code documentaryWhy ketogenic therapy challenges conventional risk-benefit analysisThe role of anecdotal evidence and N=1 experimentationPharmaceutical influence on clinical guidelinesWhy many diabetes patients feel stuck despite following standard adviceThe launch of the American Diabetes SocietyType 2 diabetes remission and low-carbohydrate nutritionWhy doctors need to stay curious and continue learningOne of the biggest themes throughout this conversation is that medicine works best when clinicians and patients stay open-minded, ask better questions, and focus on addressing root causes as opposed to just managing symptoms or lab numbers.

Protein recommendations have changed and not everyone is happy about it. Here's what the new federal protein guidelines actually mean for your health, and why the pushback is missing the point.A recent PBS article argued that doubling the current protein guidelines would push people toward junk food and processed products. But as a cardiologist, Dr. Bret Scher explains why that concern, while understandable, is misplaced. The real issue isn't the target. It's the message around how to hit it.In this discussion, you'll learn:Why the original 0.8g/kg recommendation was never designed for optimal metabolic healthWhat research shows about protein intake in the range of 1.2 to 1.6g/kgHow higher protein supports satiety, body composition, and glucose controlWhy certain groups like teenagers, athletes, and older adults need even moreHow plant vs. animal protein sources differ in bioavailability and practicalityWhy whole food sources like eggs, fish, meat, and legumes are the answer, not protein bars and packaged productsGetting more protein doesn't mean reaching for a bar or a wrapper. It means eating real food that your body knows how to use. The old 0.8g recommendation was designed to prevent decline, not to support metabolic thriving.

A new Alzheimer's study linked omega-3 fish oil (EPA & DHA) supplement use to faster cognitive decline, but the real story is far more nuanced than the headlines suggest.In this discussion, cardiologist Dr. Bret Scher breaks down the study and explains why the quality, freshness, and source of omega-3s may matter more than most people realize.The study used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and found that omega-3 supplement users experienced greater cognitive decline over five years compared to non-users. But the details matter:The study did not assess supplement quality, oxidation, dosage, or dietary habitsOxidized fish oil may behave very differently from high-quality DHA and EPAWhole food omega-3 sources like salmon, sardines, and mackerel consistently show different outcomes in researchLifestyle factors like sleep, exercise, stress, and metabolic health remain critical for brain healthOne of the biggest takeaways: supplements are not interchangeable with whole foods. And no supplement can replace the foundation of metabolic health, including nutrition, movement, sleep, stress management, and social connection.

After losing his brother to suicide despite being in psychiatric care, entrepreneur Kristian Ranta began asking difficult questions: Why do so many people struggle despite treatment? What if mental health care is overlooking key drivers of recovery?In this conversation, Dr. Bret Scher sits down with Kristian Ranta, founder of Meru Health, to explore a model that approaches mental health care differently by combining psychiatry, therapy, nutrition, metabolic health, sleep, exercise, coaching, and data-driven care.They discuss:Why nutrition and metabolic health are often overlooked in psychiatryThe connection between physical and mental healthWhy “treatment-resistant” may not tell the whole storyHow comprehensive lab testing can uncover hidden contributors to symptomsThe role of ketogenic and low-carbohydrate interventions in mental health careWearables, biofeedback, and personalized treatment approachesOutcome-based care and the future of psychiatric treatmentHow virtual care can expand access to underserved communitiesThis conversation highlights a growing movement toward whole-person mental health care, one that seeks to go beyond symptoms and understand the underlying factors that may be contributing to them.

Anorexia nervosa has one of the highest mortality rates of any psychiatric illness, yet effective biological treatments remain limited. For many people living with the condition, even after successful weight normalization, persistent psychological symptoms, including obsessive thoughts about food, shape, and weight, continue to drive relapse.In this conversation, Dr. Bret Scher sits down with Dr. Guido Frank, Professor of Psychiatry at UC San Diego with over 25 years of experience in eating disorder treatment, to discuss results from the first-ever clinical trial of ketogenic therapy in anorexia nervosa.This 14-week supervised feasibility trial enrolled 22 individuals with weight-normalized anorexia nervosa. Among the 18 study completers:✅ 72% scored in the recovered range on eating disorder assessments, no longer meeting the criteria for an anorexia nervosa diagnosis✅ 100% of study completers saw improvements in depression symptoms, with 72% scoring within the normal range.✅ Participants did not experience significant weight change throughout the studyIn this conversation, Dr. Frank also discusses:What led a self-described skeptic to investigate ketogenic therapy for anorexia nervosaHow the study was structured, who it enrolled, and what the weekly supervision looked likeWhat participants experienced as symptoms improved, including reports of mental clarity and reliefHow weight remained stable throughout the ketogenic interventionThe pushback from colleagues and how to engage with the skepticismWhat comes next, including ongoing brain imaging research and plans for a randomized controlled trialEarly observations in bulimia nervosa and what they may suggest about metabolic factors in eating disordersThis trial demonstrated that ketogenic therapy is well tolerated by this population. Larger, controlled studies are needed to better evaluate efficacy.This intervention was conducted under close supervision by a licensed eating disorder specialist, with weekly check-ins, ketone monitoring, and regular psychiatric assessments. Anyone interested in exploring this approach should do so under close medical supervision and in partnership with their care team. If you or someone you care for is living with anorexia nervosa, please speak with your healthcare provider before making any changes.

Lower triglycerides, lower remnant cholesterol, lower ApoB. Zero change in coronary artery plaque. A new clinical trial is forcing a bigger conversation about how we treat cardiovascular disease.The drug was Olezarsen, an APOC3 inhibitor. The blood work looked impressive. The heart scans did not. So why would lowering well-established cardiovascular risk factors fail to move the needle on plaque? Dr. Bret Scher argues there's a critical difference between what we want to fix and how we go about fixing it. Lowering a number with a drug is not the same as addressing the underlying metabolic dysfunction that caused that number to be high in the first place.In this video, you'll learn:What the Olezarsen trial actually showed and why the results matterWhy elevated triglycerides often signal deeper metabolic dysfunction and insulin resistanceHow this same drug-first thinking plays out in type 2 diabetes, hypertension, and weight managementWhy narrowing our focus to "fix the number" can keep us from healing the whole systemHow metabolic medicine reframes the conversation around root causesThis isn't an argument against medication. Responsible drug use has an important place in patient care. But the best outcomes come when we ask why a number is abnormal in the first place and what combination of lifestyle changes and targeted treatments will actually address it.

Could ketogenic therapy help people with schizophrenia spectrum disorders engage more successfully with CBT? A new conceptual framework explores this powerful adjunctive approach.CBTp is considered a gold-standard treatment for schizophrenia spectrum disorders, but many patients struggle to initiate, participate in, and complete it. Cognitive deficits, sleep disturbances, low distress tolerance, and ongoing psychotic symptoms can all stand in the way. In this conversation, Dr. Bret Scher sits down with licensed clinical social worker Nicole Laurent to discuss her recently published paper in Frontiers in Psychology, exploring how ketogenic metabolic therapy could help bridge that gap.In this conversation, you'll learn:Why CBTp is so cognitively demanding and where patients tend to struggleHow ketogenic therapy may reduce key barriers like sleep issues, distress tolerance, and cognitive impairmentWhat a conceptual analysis paper is and why it matters for shaping future researchHow clinicians and researchers can begin integrating these ideas into practiceWhether this framework could extend to CBT for depression, OCD, and anxietyThis discussion opens the door to thinking about ketogenic therapy not only as a direct treatment for psychiatric symptoms, but as a powerful adjunctive tool that could help patients engage more fully with the rest of their care.

How many carbs should you eat on a ketogenic diet? Do ketone levels matter? And why do cravings hit so hard? Is Dairy recommended?In this Metabolic Mailbag episode, registered dietitian and medical student Temple Stewart breaks down some of the most common challenges people face when starting and maintaining a ketogenic diet, especially for PCOS (PMOS), metabolic health, and long-term sustainability.Temple brings a unique perspective to this conversation, combining clinical nutrition experience with current medical training and a deep focus on women's metabolic health. Her approach is practical, individualized, and grounded in helping people build strategies they can realistically sustain over the long term.In this episode, we cover:Ketogenic therapy and the menstrual cycleCravings and the “sugar dragon”PCOS and therapeutic ketone levelsDairy, protein, and hungerVegetarian keto challengesCGMs and ketone testingHow to personalize a ketogenic approach long termOne of the biggest takeaways: successful ketogenic therapy is about understanding your own metabolism, building sustainable habits, and learning which strategies help you feel your best over time.

A recent report highlighted a surprising trend: individuals using GLP-1 medications such as Ozempic and Wegovy may be facing even more social stigma than those who remain overweight. And while neither deserves any stigma at all, it raises an important question about how we judge health choices in modern medicine.In this conversation, Dr. Bret Scher reflects on whether his own critiques of GLP-1 medications stem from bias against the individuals using them. His conclusion is clear: the issue is not the patient, but the system surrounding care.While GLP-1 receptor agonists can be powerful tools for weight loss and metabolic improvement, Dr. Scher emphasizes a deeper concern: the growing tendency toward a “drug-first” model that may overlook foundational lifestyle and metabolic interventions such as nutrition quality, protein intake, resistance training, and long-term behavior change.Key themes discussed:The stigma patients face regardless of whether they lose weight or notThe difference between criticizing a treatment and blaming the patientConcerns about overprescribing without adequate lifestyle supportWhat happens when medications are stopped (and weight is regained)The importance of metabolic health beyond the scaleThis conversation also highlights the complexity of long-term care. While some individuals may benefit significantly from GLP-1 medications, sustainable metabolic health ideally integrates medical tools with lifestyle-based strategies that support long-term resilience.

Psychiatric medication tapering* is becoming one of the most important and controversial conversations in mental health care.In the wake of the American Psychiatric Association Annual Conference, Dr. Bret Scher explores the growing debate around psychiatric medication “deprescribing,” responsible tapering, overprescription, and the urgent need for better research and clinician guidance.This discussion examines the real clinical questions:When should psychiatric medications be reassessed?How should tapering be approached safely?How do we distinguish withdrawal symptoms from relapse?Why is there still so little research on tapering protocols?What role could metabolic psychiatry and ketogenic therapy play in supporting brain health during treatment?Dr. Scher also discusses why every psychiatric prescription should include an ongoing plan for reassessment, not just indefinite continuation by default.Importantly, this video does NOT encourage anyone to stop psychiatric medications on their own. Decisions about medication changes should always be made carefully with a qualified healthcare provider.

A new study suggests that eating more eggs may be linked to a lower risk of dementia. But what does the research actually show?Dr. Bret Scher breaks down the headlines, the limitations of observational nutrition research, and the surprisingly important detail hidden in the baseline data.The people eating the fewest eggs entered the study with what many would consider “healthier” lifestyles:

Fatty liver disease (MASLD) is a major cause of liver disease and even liver failure. But many are surprised to learn it's not primarily a liver problem. Growing evidence suggests the root issue may be metabolic dysfunction affecting the entire body, and that perspective can drastically change how we approach treating and preventing it.In this interview, Dr. Bret Scher sits down with Dr. Adam Wolfberg to discuss a newly published study in Hepatology examining how a ketogenic intervention may help prevent metabolic liver disease before it progresses.The conversation explores MASLD (metabolic dysfunction-associated steatotic liver disease) and MASH (metabolic dysfunction-associated steatohepatitis), conditions that now affect millions of people and are closely linked to obesity, insulin resistance, and type 2 diabetes.You'll learn:Why metabolic diseases are deeply interconnectedHow ketogenic interventions may improve liver healthWhat the new research found about preventing MASLD and MASHWhy weight loss alone may not explain the benefitsHow lifestyle interventions compare to pharmaceutical approachesWhy prevention is often overlooked in modern healthcareThe broader connection between metabolic health and chronic diseaseDr. Wolfberg also explains why treating metabolic dysfunction as a whole-body condition, rather than a collection of separate diseases, may change the future of medicine.

Can insulin resistance increase the risk of suicide?In this video, Dr. Bret Scher breaks down a new study published in Translational Psychiatry that links metabolic dysfunction with higher rates of suicidal ideation, attempts, and death.Dr. Scher covers:How biomarkers like blood glucose, insulin, lipid profiles, and waist circumference relate to suicide riskHow this study fits with the growing evidence connecting metabolism to mental healthHow routinely monitoring metabolic markers could impact psychiatric careHow ketogenic and other metabolic therapies could reduce the risk of self-harmThe study adds to a growing body of evidence that mental and metabolic health are deeply connected. While more research is needed, understanding and addressing metabolic dysfunction, like insulin resistance, may be a crucial step in reducing suicide risk and improving psychiatric careExpert Featured:Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdResources Mentioned:Metabolic syndrome increases the risk of suicide attempt: evidence from a population-based cohort and genomic analysishttps://www.nature.com/articles/s41398-025-03575-1Free CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

For decades, nutrition advice has centered on a single idea: that there's one “right” way to eat for everyone. The standard low-fat, Mediterranean-style diet approach has shaped how we think about health. But it's missing a critical piece.Here, Dr. Bret Scher breaks down the limitations of universal dietary recommendations and why relying on observational nutrition research may not provide clear answers for individual health.You'll learn:Why “evidence-based” nutrition isn't always as definitive as it seemsThe difference between observational studies and causal evidenceWhy metabolic health markers like insulin, triglycerides, and body composition matter more than just weight or cholesterolHow different people respond differently to the same dietWhen low-carb and ketogenic diets may offer powerful benefitsThis discussion challenges the idea of a single “best” diet and instead explores a more personalized approach, one that considers your metabolism, preferences, and long-term sustainability.As the field evolves, the future of nutrition may lie in moving beyond rigid guidelines and toward individualized care that actually works in the real world.

Can ketosis trigger insomnia or even mania? Do you need supplements like L-carnitine to support ketone production? Is whey protein helping or hurting your metabolic health? And how do you maintain or gain weight on a ketogenic diet without losing ketosis?Harvard-trained psychiatrist Dr. Georgia Ede and cardiologist Dr. Bret Scher tackle your biggest questions in this Metabolic Mailbag episode, breaking down the science behind ketogenic metabolic therapy, including:Why some people struggle transitioning into ketosisThe role of electrolytes, protein, and meal timingBrain insulin resistance and mental healthCarnitine deficiency and ketone productionWeight loss vs. weight maintenance on a ketogenic dietProtein powders, dairy, and whole-food nutritionPractical ketogenic diet strategies for everyday lifeThis episode also explores an important theme in metabolic psychiatry: why metabolic health markers often tell us more than standard blood sugar testing alone, and how ketogenic interventions may support brain function even in people without obvious metabolic disease.Whether you're exploring ketogenic therapy for mental health, improving metabolic health, or simply trying to make keto sustainable long term, this episode is packed with practical insights and nuanced discussion.

For decades, LDL cholesterol has been the go-to metric for assessing heart disease risk. But growing research suggests there's a better predictor: ApoB. But is it a predictor in itself, or is it a marker of something even more important?Apolipoprotein B (ApoB) is a protein found on all potentially harmful lipoprotein particles, like LDL, VLDL, and remnants. Because each particle carries one ApoB, it offers a direct count of the total number of atherogenic particles, something LDL cholesterol can't do.In this video, Dr. Bret Scher breaks down the key differences between LDL and ApoB, how metabolic health influences both, and why understanding the full picture is critical for preventing heart disease.

Starting a ketogenic diet, reaching ketosis, and setting the right keto macros can feel overwhelming at first, but the fundamentals are simpler than they seem. In this video, Dr. Bret Scher breaks down how to start a keto diet step by step, including how to lower carbs, balance protein, and use fat as your primary fuel source.Whether your goal is weight loss, metabolic health, or therapeutic ketosis, this guide walks through the key principles to help you get started safely and effectively.This video covers:How to reduce carbohydrates to reach ketosisHow much protein you need on a ketogenic dietHow fat supports energy and satiety on ketoWhat causes “keto flu” and how to minimize symptomsWhy hydration and electrolytes are essentialHow to test ketones and track progressYou'll also learn how different dietary approaches, such as Mediterranean, vegetarian, and others, can still support ketosis when carbohydrates are low enough.Importantly, Dr. Scher notes that if you're using a ketogenic diet for a medical or mental health condition, it's important to work with a qualified healthcare provider. Dietary changes can affect medications and symptoms, making it crucial to have your healthcare team on board.

As interest grows in alternative approaches to post-traumatic stress disorder (PTSD), like ibogaine and psilocybin-assisted therapy, researchers are also exploring how metabolic interventions may target the underlying biology of psychiatric conditions.Dr. Bret Scher speaks with Nicole Laurent, a licensed therapist and researcher, about a published case report exploring ketogenic metabolic therapy in treatment-resistant PTSD.Together, they break down some of the biology behind PTSD, including brain hypometabolism, oxidative stress, and neurotransmitter imbalances, and how ketogenic therapy may help address these underlying mechanisms.The conversation also explores a powerful real-world case: a woman with nearly two decades of persistent PTSD symptoms who experienced profound improvements after implementing a medically supervised ketogenic approach.In this conversation, you'll also learn:Why metabolism may play a central role in psychiatric conditionsHow ketogenic therapy may support brain energy and neurotransmitter balanceThe importance of clinical supervision, especially when medications are involvedWhy individualized care and self-advocacy matter in emerging treatmentsWhile case reports don't establish causation, they can highlight new directions for research and clinical care, especially for individuals who haven't found relief with standard approaches.As research evolves, metabolic psychiatry is opening new conversations about how we understand and treat mental health conditions. If you or someone you love is living with PTSD, this discussion may offer a new perspective to explore with a qualified healthcare provider.Learn more about ketogenic therapy as an adjunct treatment for PTSD on our blog: Hope for PTSD: The Potential of Ketogenic Metabolic Therapies.

Can a ketogenic diet affect your thyroid? What about bone health, uric acid, cannabis use, or ketone supplements?In this Metabolic Mailbag episode, Dr. Bret Scher and Dr. Georgia Ede answer your most pressing questions about ketogenic therapy and how it interacts with real-world health concerns.From thyroid function to mental health, this conversation highlights how nuanced and individualized metabolic therapies can be.You'll learn:How ketogenic diets influence thyroid hormones, and why lower T3 doesn't necessarily mean hypothyroidismWhen to monitor thyroid function more closely, especially with pre-existing conditions or medications like lithiumWhat the evidence says about protein intake, uric acid, and bone healthWhy temporary changes during the adaptation phase (like uric acid fluctuations) may not reflect long-term outcomesHow cannabis use may affect appetite, cravings, and adherence to a ketogenic dietWhether exogenous ketones and MCT oil provide the same benefits as nutritional ketosisDr. Ede also shares a key principle: context matters. Lab values, symptoms, and individual biology all need to be considered together, especially when using ketogenic therapy for mental health or metabolic conditions.The key takeaway: ketogenic therapy is not one-size-fits-all. It's a dynamic, personalized approach that often requires thoughtful monitoring, adjustments, and collaboration with a knowledgeable clinician.

Can something as simple as coconut oil support brain health in dementia?In this video, Dr. Bret Scher explores an emerging area of research focused on brain energy metabolism and how ketones may play a role in supporting cognitive function in conditions like Alzheimer's disease and mild cognitive impairment.As the brain's ability to use glucose declines in Alzheimer's, researchers have begun investigating whether ketones can help fill that energy gap.In this video, you'll learn:Why the brain may experience an energy deficit in Alzheimer's diseaseHow ketones provide an “alternative” fuel for the brainThe role of coconut oil and MCTs in raising ketone levelsInsights from Dr. Mary Newport's early observations and case reportsResearch from Dr. Stephen Cunnane on brain energy metabolismWhat current studies suggest about ketogenic therapies and cognitive functionCommon concerns about saturated fat and coconut oilDr. Scher also discusses the limitations of the current evidence. While early findings are promising, much of the research is still in its early stages, and more rigorous clinical trials are needed.At the same time, for individuals and families facing cognitive decline, low-risk lifestyle approaches like ketogenic strategies may be worth exploring under medical guidance.

Exogenous ketones have exploded in popularity, with claims ranging from better brain function to improved performance and weight loss. But what does the science actually say?In this in-depth conversation, Dr. Bret Scher sits down with leading ketone researcher Dr. Dominic D'Agostino to break down the reality behind exogenous ketones—what they are, how they work, and where they may (or may not) fit into your health strategy.They explore the key differences between:Endogenous ketones (produced by your body through diet or fasting)Exogenous ketones (supplements you consume)And why that distinction matters for both metabolic and brain health.This conversation covers:The different types of exogenous ketones (salts, esters, those derived from MCTs)Potential benefits for brain energy, seizures, and metabolic healthSafety considerations and why formulation mattersWhy exogenous ketones are best viewed as a tool, not a replacement for a ketogenic dietThe concept of a “sweet spot” for ketone levels in different conditionsOne of the biggest takeaways: context is everything. Exogenous ketones may offer the most benefit when used to support a well-formulated metabolic approach, rather than as a standalone shortcut.Dr. D'Agostino also shares insights from decades of research, including work with the Department of Defense, and discusses where the science is headed, especially in areas like neurological and psychiatric conditions.

GLP-1 medications like semaglutide have been widely discussed as breakthrough treatments for weight loss and metabolic health. But a large new study published in The Lancet Psychiatry is shifting the conversation toward something deeper: the connection between metabolic health and mental health.In this video, Dr. Bret Scher breaks down what the research actually shows, and just as importantly, what it doesn't.The study analyzed health records from over 95,000 individuals with type 2 diabetes and depression or anxiety. Those taking GLP-1 medications showed a lower risk of severe psychiatric outcomes, including hospitalization and self-harm, compared to other diabetes treatments.But here's the nuance:This wasn't an intervention trial, and it didn't show that GLP-1s treat depression or lead to remission. Instead, it showed less worsening of mental health over time.This video explores:What “less worsening” really means in mental health researchWhy metabolic health and brain health are closely connectedThe limitations of large observational studiesHow GLP-1s might fit into a broader metabolic approach to mental healthThe emerging role of ketogenic therapy and other metabolic interventions

GLP-1 receptor agonists like semaglutide are often described as “game changers” for weight loss and cardiovascular health, and in many ways, the data support that claim. Clinical trials suggest meaningful reductions in major cardiovascular events, offering hope for individuals struggling with metabolic disease.But there's an important nuance that deserves more attention: what happens when these medications are stopped?In this conversation, Dr. Bret Scher explores emerging real-world data showing that the benefits of GLP-1s, particularly for cardiovascular risk, appear to depend on continued use. For many individuals, stopping the medication leads to a reversal of progress, raising important questions about long-term strategy, sustainability, and what true metabolic healing looks like.Are we managing symptoms, or addressing root causes?What role should medications play in long-term care?How can we use powerful tools like GLP-1s to support, rather than replace, sustainable metabolic change?For some individuals, long-term use may be appropriate and beneficial. But we need to broaden the conversation toward approaches that aim to improve underlying metabolic health, support lasting behavior change, and ultimately reduce reliance on lifelong interventions when possible.If you're exploring GLP-1s or are currently taking one, consider speaking with your healthcare provider about how to pair your treatment with sustainable lifestyle strategies such as nutrition, physical activity, and metabolic support, to help maintain progress over time.

We're seeing increasingly compelling results from ketogenic therapy in serious mental illness, including schizophrenia, bipolar disorder, and major depression. But what happens when a potential concern emerges along the way?In this conversation, Dr. Bret Scher sits down with psychiatrist Dr. Lori Calabrese to walk through a real patient case that highlights both the promise and the complexity of metabolic treatment.A young woman with longstanding schizophrenia experienced dramatic improvements in her mental health, metabolic markers, and quality of life after starting a ketogenic intervention. But alongside these gains, her LDL cholesterol rose significantly, raising important clinical questions.Rather than defaulting to extremes, either stopping the therapy or ignoring the lab values, Dr. Calabrese takes a thoughtful, patient-centered approach:Investigating deeper cardiovascular risk markersExploring potential underlying causes, including familial hypercholesterolemiaCollaborating across specialties, including cardiologyPrioritizing both psychiatric recovery and long-term healthThis case illustrates a critical principle in metabolic psychiatry: context matters. Lab values don't exist in isolation, and neither do patients.It also highlights a broader shift in medicine where clinicians are increasingly called to step beyond traditional silos and consider the full metabolic picture when treating brain-based conditions.At Metabolic Mind, we believe these nuanced conversations are essential. The goal isn't to ignore risk or to abandon effective therapies, but to better understand both so individuals can make informed decisions alongside their care teams.You can learn more about this conversation in the documentary The Cholesterol Code. The film shares firsthand accounts from individuals whose lives improved with ketogenic therapy, even as their LDL levels rose dramatically. It also follows how they worked with their care teams to better understand their cardiovascular risk and what that approach could mean in your own situation.

How do the latest Dietary Guidelines for Americans (DGA) and the American Heart Association (AHA) recommendations compare, and why do they differ?In this video, Dr. Bret Scher breaks down where these two major nutrition guidelines align, where they diverge, and what that means for your health. At the center of the conversation is a key question: should health be defined by a single lab marker, or by a broader view of metabolic function?In this video, you'll learn:Why LDL cholesterol is only one piece of cardiovascular riskWhy the two guidelines differ on saturated fat, red meat, and full-fat dairyThe role of markers like fasting insulin, triglycerides, HDL, and body compositionHow different dietary patterns influence metabolic health in different waysWhy recommendations around saturated fat and full-fat dairy remain controversialHow historical beliefs and evolving evidence shape nutrition guidelinesThis discussion also highlights a critical point: nutrition science is complex, and population-wide recommendations don't always translate clearly to individual health.While both organizations emphasize whole foods and reducing processed sugars and refined grains, the DGA reflects a growing recognition that there is more than one way to eat well, while the AHA continues to take a more prescriptive stance on saturated fat and animal-based foods.

People with treatment-resistant depression and anxiety are seeing real improvements through ketogenic therapy. Now there's real-world clinical data to back it up.In this interview, Dr. Bret Scher sits down with Dr. Erin Bellamy to discuss her newly published findings from a clinical program bringing ketogenic therapy into everyday mental health care.While this was not a randomized controlled trial, the results offer an important look at how these interventions may work in everyday clinical practice, with meaningful improvements reported across both depression and anxiety measures.In this conversation, you'll learn:What the study found and how to interpret the resultsThe difference between real-world evidence and randomized trialsWhy some individuals were able to achieve clinically meaningful improvements, including remissionThe role of structure, education, and ongoing support in implementing ketogenic therapyCommon challenges people face and how group support can help navigate themHow ketogenic therapy can be personalized based on individual needsThe real-life improvements participants experienced in mood, anxiety, daily functioning, and quality of lifeDr. Bellamy also shares powerful insights from her clinical experience, including how individuals with long-standing, treatment-resistant symptoms were able to make meaningful lifestyle changes, challenging the idea that people with mental health conditions cannot adhere to dietary interventions.Looking ahead, Dr. Bellamy is launching a new study through the Metabolic Psychiatry Scholar Award to further explore and scale this approach.Learn more about the impact of metabolic therapies on depression and mood disorders on our Depression Topic Page: https://www.metabolicmind.org/resources/topics/keto-for-depression/

Are we turning to ADHD and depression medications too quickly for kids?The Wall Street Journal and New York Times recently published powerful investigations into the overuse of psychiatric medications in children. In this video, Dr. Bret Scher unpacks the key takeaways, the risks of polypharmacy, and why a comprehensive, root-cause approach is more important than ever for kids facing mental health challenges.

If you carry the ApoE4 gene, you've likely been told your risk for Alzheimer's disease is significantly higher. But what does that really mean, and how much control do you actually have?In this video, Dr. Bret Scher breaks down the science behind ApoE4, one of the strongest genetic risk factors for Alzheimer's disease, and explains why increased risk does not mean a predetermined outcome.You'll learn how ApoE4 may influence brain health through inflammation, lipid metabolism, and energy use, and why lifestyle and environment play a critical role in shaping these pathways.This video also explores:Why ApoE4 does not guarantee Alzheimer's diseaseWhat research shows about traditional populations with low dementia ratesHow metabolic health, diet, and lifestyle may influence brain agingNew research challenging common assumptions about meat, fat, and dementia riskThe role of key nutrients like B12, iron, and amino acids in brain functionDr. Scher also reviews recent observational studies suggesting that higher meat consumption may be associated with lower dementia risk in ApoE4 carriers, challenging long-standing dietary narratives.The takeaway: your genes are one piece of the puzzle. Your daily choices, environment, and metabolic health may play a powerful role in shaping long-term brain outcomes.

How do we actually define “healthy food”? And how is it possible that processed, sugary cereals like Lucky Charms score higher than natural foods like eggs and meat in some food scoring systems?Dr. Bret Scher sits down with Dr. Ty Beal to explore a newly developed nutritional value scoring system designed to better reflect nutrient density, bioavailability, and chronic disease risk.Unlike many existing systems that can produce confusing or counterintuitive rankings, this approach aims to take a more comprehensive and transparent look at what makes food truly nourishing.In this interview, you'll learn:Why many popular food scoring systems fall shortWhat “nutrient density” really means and why it's more complex than it soundsHow bioavailability, protein quality, and nutrient diversity factor into food qualityThe role of ultra-processing, fiber, omega-3s, and nutrient ratios in shaping health outcomesWhy animal-source foods like meat, fish, eggs, and dairy can play an important role in a healthy dietHow this system can be adapted to different dietary patterns, including plant-based, omnivorous, and ketogenic approachesDr. Beal also shares the challenges of developing a system like this, from navigating scientific trade-offs to facing intense peer review, and why transparency and flexibility are essential when translating nutrition science into real-world tools.Importantly, this scoring system offers a framework to help individuals, clinicians, and policymakers better understand food quality within the context of overall dietary patterns and metabolic health. Rather than relying on overly simplistic labels like “good” or “bad,” tools like this can help guide more informed, personalized decisions.

Nurturing your relationship with yourself and your body can play a meaningful role in how you move forward from a mental health setback.Nicole Laurent shares a grounded, compassionate perspective on navigating setbacks. She explores how these moments can sometimes disrupt trust in ourselves, creating an internal tension that makes progress feel harder than it needs to be.She explores:Why setbacks can shake trust in your body, and how to rebuild itHow to approach challenges with curiosity instead of self-judgmentCommon triggers that can lead to going off trackHow mindset and framing influence long-term successHow your relationship with food and your body can evolve over timeThe key takeaway: setbacks are part of the learning process. Reconnecting with the idea that your body is working toward balance can help you move forward with more clarity, confidence, and resilience.

Is high LDL cholesterol always a red flag?For a growing group of people known as Lean Mass Hyper-Responders (LMHRs), the answer might not be so black and white.In this video, Dr. Bret Scher unpacks the science and questions behind LMHRs—metabolically healthy, lean individuals who see a dramatic rise in LDL cholesterol after starting a ketogenic diet. Unlike people with familial hypercholesterolemia (FH), their elevated LDL occurs in a unique metabolic context: low insulin, high HDL, low triglycerides, excellent metabolic health, and comes on only after adopting a ketogenic diet.

Are we destined for cognitive decline as we age, or do we have more control than we think?In this conversation, Dr. Bret Scher sits down with neuroscientist and researcher Dr. Tommy Wood to explore a powerful shift in how we think about brain health, aging, and dementia prevention.Dr. Wood challenges the common belief that cognitive decline is inevitable, highlighting how lifestyle, environment, and daily habits can meaningfully shape our brain's trajectory over time. He introduces his “3S Framework”—Stimulus, Supply, and Support—to explain how brain function is built, maintained, and optimized across the lifespan.In this interview, you'll learn:Why cognitive decline isn't inevitableHow mindset and engagement can influence brain agingThe role of metabolic health and energy supply in brain functionHow nutrition, sleep, exercise, and social connection interact to support the brainWhere ketogenic therapy and ketones may fit into brain health and cognitive declineHow to navigate modern challenges like technology, AI, and information overload from a brain health perspectiveDr. Wood also shares insights from his upcoming book, The Stimulated Mind, offering a practical framework to help individuals “future-proof” their brain and stay sharp in an ever-changing world.The key takeaway: brain health isn't about a single intervention. It's about consistently engaging, fueling, and supporting the brain in ways that promote resilience over time.

In this second video of our Bounce Back Series, Dr. Georgia Ede shares practical, compassionate guidance for returning to ketosis using simple, effective strategies rooted in diet and lifestyle.Rather than approaching setbacks with frustration or perfectionism, Dr. Ede emphasizes a mindset of curiosity and learning. Falling out of ketosis will happen and it's not a failure. With the right tools, you can use that information to refine what works best for your body.In this video, you'll learn:Why “ketosis interruptions” are normal and part of the processHow mindset plays a critical role in long-term successSimple strategies to return to ketosis quickly, including fasting and exerciseHow food choices can support appetite regulation and metabolic stabilityThe role of supplements like exogenous ketones and their limitationsWhy personalization is key to sustainable metabolic healthDr. Ede also explains the underlying physiology of ketosis: how insulin, glucose, and stored glycogen influence your body's ability to shift back into fat-burning mode.The key takeaway: consistency matters, but perfection isn't required. With the right approach, you can recover quickly, learn from the experience, and continue moving forward.

If you only read the headlines, it sounds simple: plants are protective, red meat is harmful. But when you examine the actual studies behind those claims, the conclusions aren't nearly so clear.In this video, Dr. Bret Scher takes a closer look at two recently published papers, one linking red meat consumption to diabetes risk and another suggesting vegetarian diets reduce cancer risk. Both studies rely on observational nutrition data, which can reveal associations but cannot prove cause and effect.In this video, you'll learn:Why many nutrition headlines oversimplify complex researchThe difference between observational studies and causal evidenceHow healthy user bias and lifestyle confounding can distort resultsWhy hazard ratios in nutrition studies are often too small to draw meaningful conclusionsHow media coverage and expert commentary can reinforce existing dietary narrativesDr. Scher explains why these studies may say more about overall lifestyle patterns like calorie intake, diet quality, alcohol use, and smoking, than about individual foods like red meat or plant-based diets.The bigger takeaway: nutrition science is nuanced, and the best diet for metabolic health may vary from person to person. Instead of focusing on simplistic narratives like “meat bad, plants good,” we should focus on improving overall dietary quality and metabolic health.

In this special episode of Metabolic Mind, Dr. Julie Milder, Director of Neuroscience at Baszucki Group, speaks with Dr. Fabiano Gomes, psychiatrist and researcher at McMaster University, and the inaugural recipient of the Baszucki Group Metabolic Psychiatry Scholar Award.Dr. Gomes recently published a pilot feasibility trial of a ketogenic diet for depression in the Journal of Affective Disorders. In this conversation, he shares how the study came together, what the results revealed, and why metabolic approaches may offer new hope for people struggling with treatment-resistant depression.In this episode, they discuss:The pilot ketogenic diet trial for depression and its key findingsHow the study successfully transitioned to a fully remote clinical trial during COVIDWhat the results suggest about feasibility, adherence, and clinical improvementsThe role of nutritional ketosis in mood disorders and metabolic psychiatryDr. Gomes' vision for launching a Metabolic Psychiatry Clinic in CanadaPlans to integrate biomarkers, brain imaging, and real-world clinical careThe importance of training clinicians and dietitians to expand access to metabolic therapiesDr. Gomes's work represents an exciting step forward in the growing field of metabolic psychiatry, which explores how metabolism and brain energy may influence conditions like depression, bipolar disorder, and other mental health disorders.The conversation also highlights the importance of building clinical infrastructure and training programs to make metabolic therapies more accessible to patients today.

Setbacks are a natural part of any journey, and mental health recovery is no exception. In this video, Dr. Matt Bernstein shares a powerful perspective on why downturns aren't failures, but opportunities to learn, adapt, and build resilience.Rather than viewing setbacks as something to fear or avoid, Dr. Bernstein explains how adopting a growth mindset can transform the way we respond to challenges. With the right preparation and support, moments of struggle can become key turning points in long-term recovery.In this video, you'll learn:Why setbacks are normal in any recovery journeyHow to reframe “failures” as opportunities for growthThe importance of identifying early warning signsHow to build a personal plan for navigating downturnsWhy support systems and connection are critical during difficult timesHow tools like mindfulness and structured planning can help you regain momentumDr. Bernstein also discusses practical strategies like creating a Wellness Recovery Action Plan, leveraging your support network, and even planning ahead for more serious crises with tools like a healthcare proxy.If you're navigating mental health challenges or supporting someone who is, this conversation offers practical tools and a more compassionate framework for the journey.

Can a ketogenic diet improve mental health?This week marks a significant moment for metabolic psychiatry and ketogenic therapy for serious mental illness.A New York Times piece highlighted early research from Stanford University, The Ohio State University, and the University of Edinburgh—alongside stories from individuals who have shared their lived experience here on Metabolic Mind.This kind of visibility matters. It reflects years of work by researchers and clinicians like Drs. Chris Palmer, Shebani Sethi, and Iain Campbell, research funded by Baszucki Group, advocates like Jan Baszucki, as well as the many people who have been willing to share their personal stories.Lived experience alone isn't enough. Early data alone isn't enough. But together, they point to something that must be tested, confirmed — or challenged — through high-quality science. That's why we are excited about several RCTs currently completed or underway around the world.We need to continue efforts to advance education, public awareness and research on a scale that will require public funding. That's how medicine moves forward. And that's the exciting work ahead.

Can the ketogenic diet help improve symptoms for individuals living with treatment-resistant depression?In this conversation, Dr. Bret Scher sits down with Dr. Megan Kirk Chang, a senior researcher in metabolic psychiatry at the University of Oxford and a co-author of the recently published DIME trial.This study represents the first randomized clinical trial to evaluate a ketogenic diet in adults with treatment-resistant depression.Participants were assigned to either a ketogenic diet or a plant-rich comparison diet for six weeks to assess whether dietary intervention could influence depressive symptoms. Both groups experienced meaningful improvements in depression scores, with the ketogenic diet slightly outperforming the control group at 6 weeks.While the difference between groups did not reach the threshold for statistical significance, the findings suggest a positive signal that warrants further investigation.In this interview, Dr. Kirk Chang reflects on:The strengths of the study and where she sees opportunity for improvement.What the modest difference between diets might meanWhy early pilot trials are designed to detect signals rather than definitive answersWhat the study revealed about adherence, cravings, and behavioral factorsHow these results will inform larger and longer clinical trials now being plannedAs Dr. Kirk Chang explains, this six-week pilot trial was designed as proof-of-concept research to determine whether there is enough signal to justify larger studies in metabolic psychiatry.At Metabolic Mind, we view studies like this as an important step in a growing scientific effort to understand how metabolism and nutrition may influence serious mental illness. Each new study contributes to the evolving evidence base that will help researchers determine who may benefit, why, and under what conditions.

A new meta-analysis just dropped, and once again, saturated fat takes center stage. But does the data actually support the decades-long warnings we've heard about saturated fat and heart disease? Not exactly.In this video, Dr. Bret Scher dives deep into a recent study published in the Annals of Internal Medicine that reviewed randomized controlled trials on saturated fat intake and health outcomes.Despite the headlines and abstract language hinting at risk, a closer look at the data reveals no statistically significant increase in heart attacks, strokes, or early death, even with modest increases in LDL.So why the disconnect between what the data shows and what the authors claim? Dr. Scher breaks it down and explores the nuances often missing from the conversation about saturated fat, including context like food quality, carbohydrate intake, metabolic health, and lifestyle factors that make a big difference.

You may have seen headlines or social media posts claiming that ketones increase the risk of heart attacks and that this proves ketogenic diets are dangerous for heart health. But when you actually examine the study behind those claims, the data tell a very different story.In this video, Dr. Bret Scher takes a closer look at a recent paper published in the Journal of the American Heart Association that analyzed circulating ketone levels in participants from the UK Biobank. The study has been widely shared online as evidence against ketogenic diets. The issue? The participants weren't following a ketogenic diet at all.Instead, researchers measured very small baseline ketone levels in a general population that was consuming around 250 grams of carbohydrates per day, that's far from the levels associated with nutritional ketosis.In this video, you'll learn:Why this study was not a ketogenic diet studyThe difference between association and causation in epidemiologyWhy the measured ketone levels were far below nutritional ketosisHow metabolic stress, illness, or diabetes can raise ketone levels independently of dietWhy these findings don't tell us anything about ketogenic dietsUnderstanding the context behind nutrition research is critical. Misinterpreting observational data can easily lead to misleading headlines and unnecessary confusion about diet and health.

Can you reverse fatty liver disease with a ketogenic diet?Fatty liver disease is now one of the fastest-growing liver conditions in the world, affecting roughly 30% of adults and an increasing number of children. And in many cases, it's driven by metabolic dysfunction and insulin resistance.In this conversation, Dr. Bret Scher speaks with Dr. Amy Goss (University of Alabama at Birmingham) and Dr. Karen Jerome-Zapadka (Trajectory Health Partners) about the growing epidemic of metabolic dysfunction–associated steatotic liver disease (MASLD) and why carbohydrate restriction and ketogenic nutrition may be powerful tools for addressing it.In this interview, you'll learn:What MASLD (formerly NAFLD) is and why it's becoming so commonHow insulin resistance and excess carbohydrates contribute to fatty liverNew research showing how carbohydrate restriction can reduce liver fatWhy ketogenic and low-carb diets may improve liver metabolism beyond weight lossThe clinical experience of reversing fatty liver through metabolic therapyWhy lifestyle approaches often receive less attention than medicationsDr. Amy Goss and her team at the University of Alabama at Birmingham are currently conducting a large NIH-funded clinical trial investigating how carbohydrate restriction affects liver fat and insulin sensitivity in adolescents with fatty liver disease.At the same time, Dr. Karen Jerome-Zapadka is applying these metabolic principles in clinical practice at Trajectory Health Partners, helping patients reverse steatotic liver disease through carbohydrate reduction and comprehensive metabolic care. Together, their research and real-world clinical experience are helping advance a deeper understanding of how targeting metabolic dysfunction may transform the way fatty liver disease is treated.Curious about the safety of ketogenic therapy? Visit our Is Keto Safe topic page to see all of our top content on the topic: https://www.metabolicmind.org/resources/topics/is-keto-safe/

A new meta-analysis of 174 randomized controlled trials on “carbohydrate-restricted diets” found consistent benefits for body composition, blood pressure, inflammation, and more. But instead of highlighting the metabolic benefits, most of the headlines focused almost entirely on a small bump in LDL.In this video, Dr. Bret Scher breaks down why that reaction misses the point and how biases in nutrition reporting are holding back real progress in improving metabolic health.

Are there real contraindications to a ketogenic diet? Yes, but they're far rarer than many people think. So who shouldn't do keto?In this video, Dr. Bret Scher breaks down the difference between absolute and relative contraindications to ketogenic therapy. While rare inborn metabolic disorders and certain acute illnesses are true absolute contraindications, most commonly cited concerns, including type 1 or type 2 diabetes, heart disease, serious mental illness, high cholesterol, and even pregnancy are listed as relative contraindications, which really means, “use caution and work with an experienced clinician.”Watch to learn who should avoid ketogenic therapy, who may benefit, and why clinical guidance makes all the difference.

Ketogenic therapy for schizophrenia, bipolar disorder, and depression is gaining attention, but how can it be safely implemented into clinical practice?A newly published expert consensus provides practical recommendations to help clinicians thoughtfully apply ketogenic metabolic therapy (KMT) for serious mental illnesses.In this in-depth conversation, Dr. Matt Bernstein and Dr. Georgia Ede, both members of the expert committee, discuss how this Delphi consensus was developed, what it includes, and how it can be responsibly integrated into psychiatric practice.In this interview, they discuss:What a Delphi process is and why it was usedThe results of the Delphi process (33 consensus statements and 10 clinical recommendations)Who may be appropriate candidates for KMTAbsolute and relative contraindicationsRecommended laboratory screening and monitoringHow long a trial should last before assessing efficacyHow clinicians can personalize implementation safelyImportantly, the authors emphasize that ketogenic metabolic therapy is not a replacement for standard psychiatric treatment. Rather, it may be considered alongside first-line therapies, particularly for individuals who have not responded adequately, cannot tolerate medications, or are seeking additional options.Reflecting on the value of this work, Dr. Bernstein shares:“I would have loved to have read this six years ago when I was starting to think about implementing these types of practices. It would have given me confidence to charge forward… I probably would have been further along now than I am.”With randomized controlled trials ongoing and more research expected in the coming years, this consensus provides a thoughtful, experience-informed framework for clinicians who are seeing growing interest in metabolic approaches.If you are a clinician, we encourage you to read the full publication.If you are a patient or family member, consider sharing this interview and the paper with your care team to support an informed discussion about whether metabolic strategies may be appropriate in your individual case.As always, clinical decisions should be made in partnership with qualified healthcare professionals.

Is a low-carb diet bad for your health? A recent New York Times article suggests so, but it leaves out critical context about ketogenic metabolic therapy and the role of metabolic health in chronic disease.In this video, Dr. Bret Scher explains why balanced reporting on low-carbohydrate and ketogenic diets truly matters, especially for people with insulin resistance, type 2 diabetes, PCOS, fatty liver disease, and many psychiatric conditions. Ketosis isn't simply “eating fewer carbs.” It's a distinct metabolic state that shifts the body's primary fuel source and has documented therapeutic benefits in multiple conditions.In this video, you'll learn:What nutritional ketosis actually is, and how it differs from general healthy eatingWhy, for some individuals, carb quantity matters just as much as carb qualityThe clinical evidence supporting ketogenic therapy for diabetes, PCOS, fatty liver, epilepsy, and mental healthWhile it's true that not everyone needs to follow a low-carb or ketogenic diet, dismissing it without a clinical perspective does a disservice to the many who could benefit.