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Jennifer Doudna developed a method of genome editing along with her partner Emmanuelle Charpentier and together they won the Nobel Prize in Chemistry in 2020. Her unique journey from graduate student to Nobel prize winning scientist is chronicled by the biographer of geniuses, Walter Isaacson. His New York Times best-seller, The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race is available now. See omnystudio.com/listener for privacy information.
Walter Isaacson is one of the preeminent biographers at work today, having written bestsellers about Steve Jobs, Albert Einstein, Benjamin Franklin, and Leonardo da Vinci. In his latest book, he tells the fascinating story of Jennifer Doudna, a recipient of the 2020 Nobel Prize who helped develop CRISPR. This revolutionary gene-editing technology was not only instrumental in the creation of the COVID-19 vaccines, but also has the potential to change how we fend off new viruses, cure virulent diseases, and have healthier babies.The 5 Key Insights1) Be passionately, playfully curious.2) Be useful.3) Know when to compete — and when to cooperate.4) Persist.5) Connect technology to humanity.For the full text of Walter's Book Bite, click here.
My goal is to read books for an hour each night. In this episode, I wanted to share some of the books that have me thinking this summer. It is a wide assortment of books that I've linked to at the bottom of the show. From technology to interpersonal skills to ponderings from history, sometimes patterns emerge between random books in surprising ways. If you have books you'd like to suggest for my reading list, message me on Twitter or use the contact us form on my website. I'd love to hear what you're reading! Today's sponsor is Lum.io, an award-winning digital learning tool that will transform your lessons into active, collaborative learning experiences If you're looking for a collaborative learning tool to make it easy to level up your lesson materials you already have with assessments, game-based activities, collaborative spaces and lots more all in one place, Lumio is the perfect choice for you. Head to Lum.io for more information and to sign up for FREE. Editing note: I used the pretty awesome Descript AI app for editing the audio. I also programmed an AI voice to overdub a few places where I made a mistake (instead of recording a word here or there.) I did have to give it permission (in my voice) and permit it to create a Voice clone of me. So far, I'm pretty impressed. As a note, this summer I'm also learning about AI and testing many apps like Descript to see where AI tools and assistants can help me be a better teacher and continue to share what I'm learning with those who find it interesting and helpful. You'll see lots of info on past blog posts and in my newsletter. Notes - https://www.coolcatteacher.com/e787 I hope you'll listen to the show to see my thoughts on this assortment of books mentioned in this episode. To Access Your Kindle "notebook" if you take notes in your Kindle - read.amazon.com/notebook Love is the Killer App by Tim Sanders How to Win Friends and Influence People by Dale Carnegie How to Take Smart Notes: One Simple Technique to Boost Writing, Learning and Thinking by Sönke Ahrens The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race by Walter Isaacson The Future is Faster Than You Think: How Converging Technologies are Transforming Business, Industries and Our Lives by Peter Diamandis and Steven Kotler The Tech-Wise Family: Every Day Steps for Putting Technology in Its Proper Place by Andy Crouch Keep Going: 10 Ways to Stay Creative in Good Times and Bad by Austin Kleon Deep Work by Cal Newport The Last Lion - Alone 1934-1940 - Part 1 - by William Manchester Author Vance Havner
This is a bit of an unusual book review for the book The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. I'm going to focus on Walter Isaacson's portrayal of how scientific research happens in academic settings and provide some context for the comments he makes on scientists, the scientific method, the role of competition, fundamental science vs. technology, and the philosophy of science. My brief bio: I did my PhD at Harvard in chemistry and postdoc in chemical engineering at Stanford. I have been in the same room with many of the individuals written about in this book, though none of them know who I am (unless they subscribe to this channel ;). I am now a professor of nanoengineering and chemical engineering, and Associate Dean for Students, in the Jacobs School of Engineering at UC San Diego.
Bestselling author Walter Isaacson, in conversation with David M. Rubenstein, discusses the life and work of the Nobel Prize-winning Jennifer Doudna who, with her collaborators, created a DNA-editing tool with the power to revolutionize human health. Recorded on February 19, 2021
In this episode, Tori and Nicole do a live unboxing of some new library books that arrived on Tuesday, February 22. Nicole runs through the nonfiction titles that will be available on shelves soon, while Tori continues to highlight books by Black authors about Black characters. The resources discussed in this episode are listed below: The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race by Walter Isaacson; Life Force: How New Breakthroughs in Precision Medicine Can Transform the Quality of Your Life & Those You Love by Tony H. Robbins, Peter Diamandis, with Robert Hariri; Beautiful Things: A Memoir by Hunter Biden; Between Two Kingdoms: A Memoir of a Life Interrupted by Suleika Jaouad; Trucking Business Startup: The Complete Step-By-Step Guide to Starting & Maintaining a Successful Trucking Company Even If You're an Absolute Beginner by Walter Grant and Gary Field; The Grieving Brain: The Surprising Science of How We Learn from Love and Loss by Mary-Frances O'Connor, PhD; Fuzz: When Nature Breaks the Law by Mary Roach; Stiff: The Curious Life of Human Cadavers by Mary Roach; Black Women, Black Love: America's War on African American Marriage by Dianne M. Stewart; I Wish I Had A Red Dress by Pearl Cleage; Things That Make White People Uncomfortable (Adapted for Young Readers) by Michael Bennett; MUTED: A Novel in Verse by Tami Charles; Surviving R. Kelly (2019) documentary; Nubia: Real One by L.L. McKinney, illustrated by Robyn Smith; Disney Magic Kingdoms mobile app; P.Tracker mobile app
Oxide and Friends Twitter Space: January 24th, 2022Taxonomy of HypeWe've been holding a Twitter Space weekly on Mondays at 5p for about an hour. Even though it's not (yet?) a feature of Twitter Spaces, we have been recording them all; here is the recording for our Twitter Space for January 24th, 2022.In addition to Bryan Cantrill and Adam Leventhal, speakers on January 24th included MattSci, Todd Gamblin, Aaron Goldman and Tom Lyon. (Did we miss your name and/or get it wrong? Drop a PR!)Some of the topics we hit on, in the order that we hit them: The tweet about the topic: Johannes Klingebiel's (2022) The five Levels of Hype taxonomy [@8:24](https://youtu.be/qrWgmkBfn9s?t=504) Roko's Basilisk (slate.com) [@10:21](https://youtu.be/qrWgmkBfn9s?t=621) Cloud Computing [@12:09](https://youtu.be/qrWgmkBfn9s?t=729) Mobile, Wi-Fi (introduced in 1997) Adam broke his hand, but can still type dtrace with one hand [@15:14](https://youtu.be/qrWgmkBfn9s?t=914) Java Write once run anywhere Cross platform graphical interfaces Windows NT [@17:47](https://youtu.be/qrWgmkBfn9s?t=1067) Storage technology Dedup ZFS copies setting and redundant_metadata InfiniBand, iSCSI Extensions for RDMA (iSER), SCSI RDMA Protocol (SRP) [@26:15](https://youtu.be/qrWgmkBfn9s?t=1575) 3D XPoint (Intel Optane) wiki HP Memristor FAQ HP “The Machine” HP research's pure hype marketing pitch The (absolutely incredible) Star Trek crossover ad > I'm gonna provide you the emotion of a revolution, but not the technical detail to > support it, not yet, but it's coming. [@31:02](https://youtu.be/qrWgmkBfn9s?t=1862) Segway (wiki) Dean Kamen wiki Decoder Ring podcast (June 2021) Who Killed the Segway? ~40mins slate.com, Apple podcasts 2001 Good Morning America Segway unveiling, Diane Sawyer is underwhelmed > I'm tempted to say “that's it??” (nervous laughter) > But that can't be it!? [@34:29](https://youtu.be/qrWgmkBfn9s?t=2069) Maglev, Cold fusion Walter Isaacson (2021) The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race book Human Genome Project wiki Hype booms and busts Todd's story on working on fusion at a national lab, and the nature of gaining funding for large projects [@45:30](https://youtu.be/qrWgmkBfn9s?t=2730) Rust [@48:43](https://youtu.be/qrWgmkBfn9s?t=2923) DTrace [@52:14](https://youtu.be/qrWgmkBfn9s?t=3134) Nanotechnology K. Eric Drexler wiki Expert Systems, AR/VR [@56:23](https://youtu.be/qrWgmkBfn9s?t=3383) Chatbots Dan Olson (Jan 2022) Line Goes Up - The Problem with NFTs ~2hr video (worth every minute) [@59:11](https://youtu.be/qrWgmkBfn9s?t=3551) Serverless Itanium IA-64, Very long instruction word VLIW Fibre Channel over Ethernet FCoE, ATA over Ethernet AoE > A solution in search of a problem [@1:06:50](https://youtu.be/qrWgmkBfn9s?t=4010) Taligent wiki Tom Hormby (2014) Pink: Apple's First Stab at a Modern Operating System post Be Inc wikiBryan's Be whiteboard story [@1:13:47](https://youtu.be/qrWgmkBfn9s?t=4427) Docker Monetizing open source [@1:20:28](https://youtu.be/qrWgmkBfn9s?t=4828) 5G If we got something wrong or missed something, please file a PR! Our next Twitter space will likely be on Monday at 5p Pacific Time; stay tuned to our Twitter feeds for details. We'd love to have you join us, as we always love to hear from new speakers!
Today, #19 in our countdown of the top 22 books of last year, as chosen by users of our Next Big Idea app: “The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race” by Walter Isaacson. In this Book Bite, Walter reflects on the brilliant people he's written about and shares the five lessons they've taught him about how to be creative; how to be imaginative; and, as Steve Jobs put it, how to “think different.” Check out Walter's interview with Rufus: https://apple.co/3nSbIi8 To hear more Book Bites, download the Next Big Idea app: nextbigideaclub.com/app
Today, #19 in our countdown of the top 22 books of last year, as chosen by users of our Next Big Idea app: “The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race” by Walter Isaacson.In this Book Bite, Walter reflects on the brilliant people he's written about and shares the five lessons they've taught him about how to be creative, how to be imaginative, and, as Steve Jobs put it, how to “think different.”Check out Walter's interview with Rufus: https://apple.co/3nSbIi8To hear more Book Bites, download the Next Big Idea app: www.nextbigideaclub.com/appSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Today's episode of the podcast is from a February 2021 interview with Ryan Holiday and prolific bestselling author Walter Isaacson. They talk about his newest book The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race, the brilliant execution that it took to create the first Coronavius vaccine, demystifying the scientific narrative through a journey of discovery, and more.For THREE MORE DAYS, you can sign up and immediately begin the 2022 Daily Stoic New Year New You Challenge at your own pace. It's 3 weeks of actionable challenges, presented in an email per day, built around the best, most timeless wisdom in Stoic philosophy. Just go to https://dailystoic.com/challenge to sign up.Sign up for the Daily Stoic email: https://DailyStoic.com/dailyemailCheck out the Daily Stoic Store for Stoic inspired products, signed books, and more.Follow us: Instagram, Twitter, YouTube, TikTok, FacebookSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Gene-editing technology comes with promises and fears. But because inventions will continue, we take them as spiritual opportunities to respect humanity with a proper zeal for divine Spirit. The book, Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race, by Walter Isaacson, is referenced for CRISPR technology and history. The Bible, I Kings, is referenced for a story about Elijah, learning God isn't in fire but in "the still small voice." www.Christ-Scientist.com
Sou um dos pioneiros no conceito Biohacking & Otimização da saúde no Brasil. Em minhas palestras, conteúdos, eventos sempre digo que NÓS somos ALGORITMOS! Estamos entrando de vez na era das “tecnologias do self''. O nosso corpo é a mais recente plataforma de inovação.Estamos cada vez mais buscando técnicas para controlar o nosso próprio corpo, pensamentos e comportamento. Percebemos que muitas técnicas individuais e seus significados mudaram ao longo dos séculos. O Google está se tornando cada vez mais consciente do nosso comportamento, nossos verdadeiros desejos, nossos anseios e preocupações (mais conscientes até que nós mesmos). No século 21, as invenções não estarão concentradas em melhorar os padrões de vida das pessoas, mas otimizar as próprias pessoas: de prevenção de doenças para melhorar a biologia humana a atingir o aprimoramento da nossa vida, algo que prolongará ainda mais nossa existência( Hackeando humanos) A principal ferramenta do século 21 é sim nossos corpos, cérebros , intestinos e corações! Desde 2017 venho fazendo conteúdo sobre o tema Biohacking & Health Optimisation, nesse período li vários livros, participei de vários eventos sobre o tema, e resolvi selecionar alguns livros que fizeram a diferença em minha vida. Biohacking lentamente ganhou popularidade recentemente, e sua abordagem mais conhecida vem do livro mais vendido e do guia de estilo de vida de Dave Asprey, “The Bulletproof Diet”. Em suma, a prática Biohacking se concentra em uma relação que sempre cito em meus artigos, há uma clara relação entre” inputs” e ”outputs” no seu corpo, relação que inclui sentimentos, alimentos, hábitos enfim tudo que colocamos em nossos corpos afeta nossos resultados gerais, incluindo tudo, desde concentração até estresse e níveis de energia. #1 Ferriss, Timothy. 4 horas para o corpo. Intrínseca, 2012. #2 Asprey, Dave, e Valéria Prest. Bulletproof: A dieta à prova de bala: Recupere a energia e a concentração e faça um upgrade em sua vida. 1a edição, Bicicleta Amarela, 2016. #3 Asprey, Dave. Head Strong: The Bulletproof Plan to Activate Untapped Brain Energy to Work Smarter and Think Faster-In Just Two Weeks: 3. Illustrated edição, Harper Wave, 2017. #4 DiClementi, Anthony. The Biohacker's Guide to Upgraded Energy and Focus. Biohacking Secrets, 2016. Siga-me-- Site- www.tiagopereiras.com.br -Instagram –https://www.instagram.com/t1agopereiras/ https://www.instagram.com/tiagopereirascanvas2-Twitter – https://twitter.com/t1agopereiras-Facebook – https://www.facebook.com/t1agopereiras -- Podcast ‘'Always in beta''-- https://open.spotify.com/show/68lweLSna3KOW0Dzqd8Qjr?si=tk3v-AKGRfqFhU4WaENE2g - Telegram- https://t.me/joinchat/H2kyExT956xehPWJIJrneg Google Recompensa: https://googleopinionrewards.page.link/share OYO Hotéis 35%OFF https://share.oyorooms.com/TIAGQ7DOOR?sp=app -Cashback Meliuz- https://www.meliuz.com.br/i/ref_99e1c94b?ref_source=27 Fiverr http://www.fiverr.com/s2/569710a0f3#5 Greenfield, Ben. Boundless: Upgrade Your Brain, Optimize Your Body & Defy Aging. Illustrated edição, Victory Belt Publishing, 2020. #6 Ferriss, Tim, e Bruno Casotti. Ferramentas dos Titãs: As estratégias, hábitos e rotinas de bilionários. celebridades e atletas de elite. 1a edição, Intrínseca, 2018. #7 Asprey, Dave. Super Human: The Bulletproof Plan to Age Backward and Maybe Even Live Forever: 5. Harper Wave, 2019. #8 Sinclair, David A., e Matthew D. Laplante. Lifespan: Why We Age--And Why We Don't Have to. Unabridged edição, Simon & Schuster Audio, 2019. #9 Lundgren, Magnus, et al.,organizadores. CRISPR: Methods and Protocols. 2015th edition, Humana, 2015. #10 Isaacson, Walter. The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. Simon & Schuster, 2021. --- Support this podcast: https://anchor.fm/t1agopereiras/support
Get the audiobook for free on Amazon: https://geni.us/code-free-audiobook (https://geni.us/code-free-audiobook) For the full transcript, PDF, infographic and animated book summary, check out our free app: https://www.getstoryshots.com (https://www.getstoryshots.com) The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race by Walter Isaacson Summary and AnalysisLife gets busy. Has https://geni.us/code-free-audiobook (The Code Breaker) been gathering dust on your bookshelf? Instead, pick up the key ideas now. We're scratching the surface here. If you don't already have the book, order it https://geni.us/code-breaker-book (here) or get the https://geni.us/code-free-audiobook (audiobook for free) on Amazon to learn the juicy details. Disclaimer: This is an unofficial summary and analysis. Please consult a professional before attempting to experiment with gene editing. Walter Isaacson's Perspectivehttps://geni.us/walter-isaacson (Walter Isaacson) is a historian, journalist, and proclaimed biographer. He is currently a Professor of History at Tulane and an advisory partner at Perella Weinberg Partners, a financial advisory firm. His former positions include CEO of the Aspen Institute, chairman of CNN and TIME magazine editor. In literature circles, Isaacson is well-known for his biographical efforts. He is the author of best-selling biographies of Steve Jobs, Albert Einstein, Benjamin Franklin, and Leonardo da Vinci. Introductionhttps://geni.us/code-free-audiobook (The Code Breaker) is a fascinating ode to scientists who made remarkable discoveries about our genome. It focuses on Jennifer Doudna, who received the 2020 Nobel Prize in Chemistry, and her colleague, microbiologist Emmanuelle Charpentier. Although the Nobel-prize-winning gene-editing pioneer is the central figure of this publication, Isaacson offers to look at other scientists, their discoveries, and how they can change our lives. According to Isaacson and the scientific community, Doudna's findings promise to cure many life-threatening illnesses. Bill Gates chose The Code Breaker as one of his top 5 favorite books of 2021. StoryShot #1: The Double Helix Changed Jennifer Doudna's LifeThe first quarter of The Code Breaker provides a brief biography of Jennifer Doudna. As a child, she found her aspiration in learning and education. When she was in sixth grade, she understood that she wanted to connect her life with chemistry and genetics. One day, she came home from school and found a book called “The Double Helix” by James Watson. The girl thought it was a detective book and put it aside. A few weeks later, she decided to give it a chance. Although it wasn't the book she envisioned, it turned out to be a detective book somehow. The Double Helix talked about people who tried to unravel the ultimate mysteries of human life. The adventure to untangle our DNA was loaded with fascinating characters, fruitful partnerships, and contention. The book became an inspiration for little Jennifer to become a scientist. Growing up, she was told that “women don't become scientists.” Despite many challenges, Doudna got to establish herself as a biochemist. Eventually, she unraveled the mystery that remained unsolved in The Double Helix. StoryShot #2: CRISPR Gene-Editing is Used to Cure Cancer, Create Vaccines and Designer Babies CRISPR is the remarkable discovery Doudna and her colleagues made. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats. It is a system bacteria have used for millennia to combat viruses. When a virus attacks bacteria, they remember a portion of its code. If the virus returns later, the bacteria can use knowledge of its code to tackle the virus. This mechanism is essential for living organisms to develop immunity to viruses they faced before. This is what we need to defeat COVID-19 and many future pandemics. In fact, instead of simply...
Throughout nearly the entirety of human history, we have accepted a simple truth: A person's genetic makeup is beyond one's choice. Until now. In 2020, the Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna for the development of CRISPR, a method for genome editing. CRISPR may change everything -- and land us in a world previously imaginable only in science fiction. CRISPR can be wonderful and incredible. It may eliminate a child's susceptibility to a genetic condition, such as cleft lip or cystic fibrosis or devastating disease. Imagine that. However, it also makes it possible to choose a child's height or hair color. With these and other possibilities, the moral and ethical implications are important and immense. The race to discover CRISPR was one of the great science tales of the 21st century, a cross-continent battle of discovery and speed. So how did CRISPR arrive? And more importantly, where might it take us? Walter Isaacson is one to tell that story -- a professor of history at Tulane, he has been CEO of the Aspen Institute, chair of CNN, and editor of Time. He has written numerous No. 1 best-selling books, including on Leonardo DaVinci, Steve Jobs, Albert Einstein, and Ben Franklin, each one of the great creators of their time, who transformed not only their fields, but also the way humans connect -- offering new ways to think about and engage in meaningful human interaction. Isaacson's latest book is The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. It's part mystery, part science, part personal, and completely compelling. Isaacson details the discovery of the CRISPR method and tells the story of the groundbreaking, female scientists who revolutionized the world.
Programming Note: Anticipating The Unintended will be on its annual year-end break for the next two weeks. Normal services will resume from Jan 9, 2022. Happy Holidays.This is the last edition for 2021. There’s always a temptation to look back at the year gone and arrive at some kind of things-we-learnt-this-year list. As much as we’d like to do that, we really have nothing insightful to offer. It wasn’t a great year for most part because of the pandemic and it is ending on a foreboding note. Anyway, so what do we have in this year-end edition? We start with talking about the one overriding emotion that the two of us had through the year. What’s that one constant feeling that summed up our view of most events during the year? We then move on to the predictions we had made at the start of 2021 and see how each of us fared. And we close out with books, newsletters, podcasts or videos that we enjoyed greatly. That’s what is on the menu today.The 2021 State Of MindRSJ: Through the year my mind went back to the lines from one of my favourite poems, The Second Coming by W.B. Yeats. It is somewhat apposite too. Yeats wrote the poem just after WW-1 had ended and during the Spanish flu pandemic. His pregnant wife contracted the flu and survived after a harrowing time. Yeats paints a bleak landscape of disorder and anarchy with warring factions and a divided world order. The voices of reason lack moral strength because the false convictions of the passionate have taken over. To quote Yeats:“The best lack all conviction, while the worstAre full of passionate intensity.”That’s how I felt most of 2021. Funnily enough, I started noticing many variations of these lines over the past months. I guess I lived through the Baader-Meinhof phenomenon on this one. I have collated them here. Back in 1871, in the introduction to his book, Descent of Man, Charles Darwin wrote:“Ignorance more frequently begets confidence than does knowledge: it is those who know little, and not those who know much, who so positively assert that this or that problem will never be solved by science.”In his 1931 essay, The Triumph of Stupidity, Bertrand Russell wrote:“The fundamental cause of the trouble is that in the modern world the stupid are cocksure while the intelligent are full of doubt. Even those of the intelligent who believe that they have a nostrum are too individualistic to combine with other intelligent men from whom they differ on minor points. This was not always the case. A hundred years ago the philosophical radicals formed a school of intelligent men who were just as sure of themselves as the Hitlerites are; the result was that they dominated politics and that the world advanced rapidly both in intelligence and in material well-being.It is quite true that the intelligence of the philosophical radicals was very limited. It is, I think, undeniable that the best men of the present day have a wider and truer outlook, but the best men of that day had influence, while the best men of this are impotent spectators. Perhaps we shall have to realise that scepticism and intellectual individualism are luxuries which in our tragic age must be forgone, and if intelligence is to be effective, it will have to be combined with a moral fervour which it usually possessed in the past but now usually lacks.”In his essay, A Cult of Ignorance, published in the Newsweek (1980), Isaac Asimov wrote:“Anti- intellectualism has been a constant thread winding its way through our political and cultural life, nurtured by the false notion that democracy means that my ignorance is just as good as your knowledge.Now we have slogans on the part of obscurantists: "Don't trust the experts!"... We have a new buzzword too, for anyone who admires competence, knowledge, learning and skill, and who wishes to spread it around. People like that are called 'elitists'....What shall we do about it? We might begin by asking ourselves whether ignorance is so wonderful after all, and whether it makes sense to denounce 'elitism'. I believe that every human being with a physically normal brain can learn a great deal and can be surprisingly intellectual. I believe what we badly need is social approval of learning and social rewards for learning.”Of course, all of this culminated into a wonderful paper by David Dunning and Justin Kruger titled, “Unskilled and unaware of it: How difficulties in recognizing one’s own incompetence lead to inflated self-assessments”. Published in the Journal of Personality and Social Psychology, Dec 1999, the abstract of the paper asserted:“People tend to hold overly favorable views of their abilities in many social and intellectual domains. The authors suggest that this overestimation occurs, in part, because people who are unskilled in these domains suffer a dual burden: Not only do these people reach erroneous conclusions and make unfortunate choices, but their incompetence robs them of the metacognitive ability to realize it.”Thus was born the Dunning-Kruger effect. It owned 2021.Pranay:As for many of you, 2021 was my first year, in many many years, spent entirely at home. Until 2021, there were two neat compartments in my head: a ‘professional’ one and a ‘personal’ one. I associated terms such as ambition, learning, and planning only to the ‘professional’ compartment. On most issues outside that sphere, I thought I could just wing it. To use RSJ’s framing, it was the Dunning-Kruger effect at play in one compartment of life. So, 2021 has been about trying to unlearn many erroneous conclusions I had reached about wellbeing (physical and mental), parenting, relationships, and self-worth. There’s a lot to learn. But just the dissolution of the false assumption that two very different approaches apply to the two spheres of life is liberating. Our Predictions Report CardAt the start of this year, we were foolhardy enough to make a few predictions. We will see how we fared on them.RSJ:Pranay had made an important point about predictions then:“... predictions are susceptible to what Philip Tetlock calls ‘outcome-irrelevant learning’ — a situation wherein no matter the reality, people are in an excellent position to explain that what happened was consistent with their view.One way to check outcome-irrelevant learning is first to make specific, measurable predictions and then reflect on real-world outcomes at the end of the prediction horizon. Which, for this newsletter, means we will do another post at the end of 2021 reflecting on our hits and misses.”I must admit my 10 predictions didn’t exactly fit Pranay’s definition of being specific and measurable. So, as I look back, you can accuse me of conveniently retrofitting the actual outcomes to them. FWIW, let’s see how I fared.Prediction 1: By the end of 2021, we will all realise we overrated the long-term impact of the pandemic on everything. There won’t be any ‘new normal’ to write home about. Things will be more of the same.Outcome: Largely true, I would think. Maybe 6/10 on accuracy. No dramatic shift seen on anything yet. Prediction 2: The size of the stimulus in most developed economies and the amount of liquidity pumped into the system will mean two things – eventual inflation and a repeat of the taper tantrum in future. Deficits have come to mean nothing and any future slowdown in the economy or fall in markets will mean more stimulus.Outcome: Not bad. I guess 7/10 on this.Prediction 3: The stock markets are in bubble territory now. But there won’t be any reckoning in 2021. The stocks doing well during the pandemic will continue to do well. The divergence between the real economy and the street will continue to confound all of us.Outcome: Cannot complain. 7.5/10Prediction 4: The early signs are of a K-shaped recovery around the world. This will be strengthened in 2021. A small set of companies and people will see a rising graph of growth and prosperity. The long-term impact of the pandemic will be to worsen inequality. The early but definite signs of this will show up in 2021.Outcome: Again 7.5/10Prediction 5: Credit offtake will be weak and the revival of consumption story will be dampened because of this. Private investments were trending downwards anyway before the pandemic. Its revival seems unlikely in 2021.Outcome: Maybe 7/10Prediction 6: The Chinese economy will lead the global growth engine. Despite its misadventures during the pandemic, China will continue its rise to the top. The Biden administration will take a more accommodative stance towards China. The trade war will subside and the EU will continue to strengthen its relationship with China. Outcome: Mostly wrong. China has continued to do well but it has its problems. 3/10Prediction 7: Technology sovereignty will be a key theme in 2021. Countries across the western world will assert their technology independence. The most common form this will take is in keeping Chinese technology companies out of strategic sectors like telecom and finance infrastructure services. Or you could expect heavy fines for restrictive or anti-competitive practices and heavier hand of regulations on these (big tech) companies.Outcome: Largely right. China itself came down heavily on its tech giants while Lina Khan, the chair of FTC, continued her tirade against Big Tech. 6/10Prediction 8: How to vaccinate India will be a policy question that will keep everyone busy in the first half of 2021. Everything about vaccines – procurement, pricing, storage, administration and safety – will test our policymakers. My guess is we will do quite well in this entire exercise. Outcome: I guess we did better than what we expected at the start of 2021. We are still behind on booster doses and vaccines for kids though. 7/10Prediction 9: It won’t be a great year for reforms. The wrong lessons will be learnt from the protests against farm law reforms. Plus, the usual set of assembly elections and the weak economy post the pandemic will continue to weigh on the government. So good, bold and much-needed reforms across sectors will again go into the backburner. Outcome: Cannot disagree. Barring Air India sale and some boost to manufacturing, not much happened here. The start-up story isn’t really a government story to own. Then there was the farm law repeal. Enough said. 7/10Prediction 10: The BJP election machine will have a mixed year. Barring Assam where it should keep its majority and some gains in West Bengal, it won’t see much success. The campaign and the narrative building leading up to elections in Assam and West Bengal will not be for the faint-hearted. There will be a plethora of fake news, violence and no-holds-barred Muslim bashing. The signs are already there on the news channels. The opposition will remain largely ineffective with some kind of split happening in the Congress during the year. But there will also be the earliest sign of some kind of coming together of regional parties to counter BJP in 2024. This seems inevitable.Outcome: Well, that looks fairly accurate. So 8/10.Overall, not bad but I will try to be more specific about next year’s predictions.Pranay:This is the report card of the five predictions I made at the start of 2021. Prediction 11: Petrol prices in Bangalore will hit ₹100 at least once before the end of 2021.Outcome: Petrol prices were at ₹86.47 in Bengaluru on 1st Jan 2021. The prediction was based on the reasoning that excise duties on petrol and diesel are the superhero of last resort for state and union governments. As public spending rose in the backdrop of the second wave of COVID-19, both union and state governments took the easy route of increasing taxes on petrol and diesel. Petrol prices hit the hundred mark in June and galloped to ₹113 by November. Since then, they have settled to just above ₹100. Of course, there were no nationwide protests over the issue. No electoral results were attributed to this price hike, even though the rising inflation would have hit many people hard. Prediction 12: A maximum of 2 CPSUs will be privatised by the end of 2021.Outcome: The backdrop of this prediction was the buzz surrounding the union government’s grand scheme to sell its stake in over 25 CPSUs. The Ministry of Finance’s reply in the Lok Sabha has the details. And from what I can gather, just two CPSUs have found a buyer this year — Air India and Central Electronics Limited.Prediction 13: GST will continue to have the current five tax slabs.Outcome: My reasoning behind this prediction was that the fiasco on the GST compensation cess has broken the trust between union and state governments, and the latter will not welcome any further changes in the GST regime this year. Prediction 14: The status quo at Ladakh in terms of territorial control will continue.Outcome: Just yesterday, the Indian Air Force Chief had this to say: “the standoff does continue. Disengagement has taken place in certain areas in Eastern Ladakh. But, the complete disengagement has not yet been done I would not like to go into the details, but suffice to say we are deployed, we are prepared to take on any challenge that may face us in that area with the shortest of notice.”Prediction 15: The number of US service personnel in Afghanistan will fall below 2500 by the end of 2021.Outcome: The prediction turned out to be true of course. But little did I expect that the withdrawal would put the Taliban in full control of Afghanistan. Finally, I also had a note related to RSJ’s prediction on US and China. The Biden administration has, indeed, continued key elements of the previous administration’s trade policies on China. In the high tech domain, the restrictions are likely to tighten further.These were my five predictions. In retrospect, it looks like I made some safe (and obvious?) bets. Read, Saw Or HeardWe will close with our top recommendations of books, podcasts, newsletters et al, that we came across in 2021. RSJ: In no particular order, here are mineThis Is How They Tell Me The World Ends: The Cyberweapons Arms Race. A riveting take on global cyber warfare by Nicole Perloth that reads like a thriller. Deservingly won the 2021 Financial Times Business Book of the Year award.The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. Walter Issacson’s book couldn’t have been more timely. The history of gene editing, development of CRISPR and how all of it came together to create vaccines for Covid-19 are all part of this absorbing and informative book. The Light that Failed: A Reckoning. Krastev and Holmes on why liberal democracy faltered in eastern Europe. There are lessons for everyone there. India’s Founding Moment: The Constitution of a Most Surprising Democracy. Madhav Khosla’s wonderful narration of the people, the ideas and the debates that went into the creation of our Constitution. Wanderers, Kings, Merchants: The Story of India through Its Languages by Peggy Mohan. A forensic on Indian languages and what they tell us about our history and the evolution of our culture. Civilisation and reclaiming of it is often thrown about loosely in India these days. Our languages hold the secrets of our civilisation. Understanding them may be a useful precondition to whatever it is we are trying to reclaim. Klara and the Sun by Kazuo Ishiguro. A peek into our future where kids are kept company by artificial friends but love still makes the world go round. The Plot by Jean Hanff Korelitz. A ‘howdunit’ that keeps you engrossed till the end though you figure out the climax two-thirds of the way. Surprising that way.The Reith Lectures: Pranay introduced them to me and I have been hooked since.The Lex Fridman Podcast: The ‘Amit Varma, Sam Harris and Russ Roberts rolled into one’ of science and tech podcasting. Long episodes (many over 5 hours) about deep tech, AI, string theory, ultramarathons, truck driving and whatever else that catches Lex’s fancy.Ideas of India by Shruti Rajagopalan: Great conversations and a much needed platform to hear from young scholars about their work on India. Newsletters: Noahopinion by Noah Smith (original and insightful) and Chartbook by Adam Tooze (the best place to find out about new books and interesting ideas). Also, Strange Loop Canon by Rohit (no idea about his last name) and SneakyArt Post by Nishant Jain - two newsletters from Indians based abroad that I found interesting. Read them.There were other books (esp fiction) and interesting podcast episodes to share but maybe some other time Pranay:Humankind: A Hopeful History challenged my Bayesian priors like no other book this year.The Quillette online magazine usually has pieces that go against the prevailing dominant narratives. Womaning in India newsletter taught me a lot. Anirban Mahapatra’s Gyandemic newsletter is full of TILs on new science findings.Your Undivided Attention Podcast convinced me that our information environment is polluted and we need to take charge of our consumption choices. Take care. Stay safe. See you in 2022. Subscribe at publicpolicy.substack.com
What do Steve Jobs, Leonardo da Vinci, Benjamin Franklin and Jennifer Doudna all have in common? Celebrated journalist and author Walter Isaacson calls upon his years of research to explain how curiosity has always fueled creativity among history's greatest innovators, and how each of those individuals shaped the world around them. On this episode Issacson dives deep into the curious obsessions of Jobs, da Vinci's ability to develop a brilliant mind, Ada Lovelace and how she developed the algorithm, and how Doudna's work with gene editing could shape the future to come. A journalist by trade, Issacson served as the editor of Time and then chairman and CEO of CNN before eventually spending 15 years as president and CEO of the Aspen Institute, the international research institute and think tank. Isaacson has also written bestselling biographies on Jobs, da Vinci, Franklin and Albert Einstein, and in 2021 released his latest biography, The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. Go Premium: Members get early access, ad-free episodes, hand-edited transcripts, searchable transcripts, member only episodes, and more. https://fs.blog/knowledge-project-premium/ Every Sunday our newsletter shares timeless insights and ideas that you can use at work and home. Add it to your inbox: https://fs.blog/newsletter/
Welcome back to Zillennials Podcast Book Club! This month we read The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race by Walter Isaacson. This is a nonfiction pick that covers the history of DNA & RNA, the life of Jennifer Doudna, and how we came to a world where gene editing is possible. Kaylee and Lian will discuss the parts of the book that they found most interesting, their personal opinions on gene editing, and their overall impression of the book in this episode.
Author Walter Isaacson explains what the discovery of the gene-editing tool CRISPR relates to the science behind COVID-19. He discusses his newest biography featuring the co-inventor of CRSIPR, "The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race." See omnystudio.com/listener for privacy information.
When curiosity meets creativity, Walter Isaacson is there to tell the story. In each of his biographies, Isaacson serves as the ultimate reporter. He's covered some most fascinating subjects in human history and shared their personal stories with the world. Isaacson discusses his creative process, the subjects of his biographies and the ethics of gene editing with host Charles Mizrahi. Topics Discussed: • An Introduction to Walter Isaacson (00:00:00) • Choosing the Right Subject (00:01:26) • Sitting With Kissinger (00:08:19) • Gratitude & Humility (00:11:21) • Fairness in Biographies (00:12:16) • Preachers vs. Storytellers (00:15:11) • The Code Breaker (00:21:06) • Designing Our Children (00:27:11) • Morality, Ethics and Gene Editing (00:30:09) • The Next Subject (00:37:31) Guest Bio: Walter Isaacson is an author, journalist and professor. After graduating from Oxford and Harvard University, Isaacson began his career in journalism. Since then, he's served in several senior positions at news organizations such as TIME Magazine and CNN. In addition, he held a 15-year tenure as president and CEO of the Aspen Institute. Today, Isaacson teaches history at Tulane University and is a senior adviser for Arcadia Publishing. Isaacson's own published works include several bestselling biographies on genius minds and Nobel Prize-winners alike. You can find these books below. Resources Mentioned: https://www.amazon.com/gp/product/B08G1XNG7J/ref=dbs_a_def_rwt_hsch_vapi_tkin_p1_i0 (The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race) https://www.amazon.com/gp/product/B071Y385Q1/ref=dbs_a_def_rwt_hsch_vapi_tkin_p1_i1 (Leonardo da Vinci) https://www.amazon.com/gp/product/B00AK78QAY/ref=dbs_a_def_rwt_hsch_vapi_tkin_p1_i9 (Kissinger: A Biography) https://www.amazon.com/gp/product/B000FBJG4U/ref=dbs_a_def_rwt_hsch_vapi_tkin_p1_i4 (Benjamin Franklin: An American Life) https://www.amazon.com/gp/product/B000PC0S0K/ref=dbs_a_def_rwt_hsch_vapi_tkin_p1_i5 (Einstein: His Life and Universe) https://www.amazon.com/gp/product/B004W2UBYW/ref=dbs_a_def_rwt_hsch_vapi_tkin_p1_i2 (Steve Jobs) Transcript: https://charlesmizrahi.com/podcast/2021/08/03/history-science-future-of-the-human-race-walter-isaacson/ (https://charlesmizrahi.com/podcast/) Don't Forget To... • Subscribe to my podcast! • Download this episode to save for later • Liked this episode? Leave a kind review! Subscribe to Charles' Alpha Investor newsletter today: https://pro.banyanhill.com/m/1729783
Adam and I discuss Committed: Dispatches from a Psychiatrist in Training, how psychiatry differs from other medical fields, imposter syndrome, how he handled the legal issues related to his book, positive changes to the medical industry resulting from the pandemic, the value of personal connection, and much more. Adam's recommended reads are: The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race by Walter Isaacson Greenlights by Matthew McConaughey Support the podcast by becoming a Page Turner on Patreon here. Other ways to support the podcast can be found here. If you enjoyed this episode and want to listen to more episodes, try Jess McHugh, Cate Doty, Philip D'Anieri, Julia Cooke, and Ly Tran. Committed: Dispatches from a Psychiatrist in Training can be purchased at the Conversations from a Page Bookshop storefront. Learn more about your ad choices. Visit megaphone.fm/adchoices
Author Walter Isaacson discusses his recent book "The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race", a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies. Bestselling author of "Steve Jobs" (2011), "Einstein: His Life and Universe" (2007) and more, Walter Isaacson has established himself as the biographer of creativity, innovation, and genius. Einstein was the genius of the revolution in physics, and Steve Jobs was the genius of the revolution in digital technology. We are now on the cusp of a third revolution in science, a revolution in biochemistry that is capable of curing diseases, fending off viruses, and improving the Human species itself. The genius at the center of his newest book "The Code Breaker" is American biochemist Jennifer Doudna, who is considered one of the prime inventors of CRISPR, a system that can edit DNA. Moderated by Leigh Gallagher. Visit http://g.co/TalksAtGoogle/CodeBreaker to watch the video.
In this episode, Anthony is joined by award-winning author and journalist Nina Burleigh, to discuss her new book ‘Virus: Vaccinations, the CDC and the Hijacking of America’s Response to the Pandemic,’ and what she’d say to the many people resisting the coronavirus vaccine.Walter Isaacson is a renowned author, journalist and professor and talks with Anthony about his new book, ‘The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race,’ his career as a biographer - and the common traits found in groundbreaking people. Finally, Tim Robinson, partner at Schillings and former major general in the British Army, illustrates how skills required in a war zone such as “action-oriented” leadership can be applied to the boardroom, and what steps we can take to deal with the impending threat of disinformation. Follow our guests on Twitter:https://twitter.com/ninaburleigh https://twitter.com/WalterIsaacson Follow us:https://twitter.com/moochfm https://twitter.com/scaramucci Sign up for our newsletter at:www.mooch.fm Created & produced by Podcast Partners:www.podcastpartners.com
Walter Isaacson is the Author of “The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race”. Isaacson is famous for writing Steve Jobs and Leonardo da Vinci, so a title like The Code Breaker might imply a lesser book about a lesser character. But 2020 Nobel winner Jennifer Doudna, who developed the gene editing technology CRISPR, is a giant in her own right. CRISPR could open some of the greatest opportunities, and most troubling quandaries, of this century—and this book delivers. Isaacson is a Professor of History at Tulane and an advisory partner at Perella Weinberg, a financial services firm based in New York City. He is the past CEO of the Aspen Institute, where he is now a Distinguished Fellow, and has been the chairman of CNN and the editor of TIME magazine. ————————————————————————— For podcast transcripts and show notes, visit *salt.org/talks* ( http://salt.org/talks ) Watch this video on YouTube: *https://youtu.be/1gfTyPcIH7Y* ( https://youtu.be/1gfTyPcIH7Y ) Developed, created and produced by SALT Venture Group, LLC. Moderated by Anthony Scaramucci.
If On Purpose inspires you, Jay's exclusive Genius workshops and meditations will take your life to the next level. Go to https://shetty.cc/OnPurposeGenius to learn more. The world has been forever changed by the simple question: What if? What if Leonardo Da Vinci never painted the Mona Lisa? What if Steve Jobs never started Apple? What if Jennifer Doudna never pursued gene editing? On this episode of On Purpose with Jay Shetty, Jay speaks with acclaimed author and journalist, Walter Isaacson, about his new book, Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race.
Jennifer Doudna has changed the life-science field. In 1987, she and her collaborators created CRISPR, an easy-to-use tool that can edit DNA, and opened a brave new world of medical miracles. Conversely, the invention of CRISPR raised many moral questions. With the device, scientists can now detect and destroy DNA, hypothetically making humans less susceptible to viruses, preventing depression, enhancing individual height or muscles or IQ. In his new book The Code Breaker, famed biographer Walter Isaacson follows Doudna from when she first learned what “the double helix” is all the way to her winning the 2020 Nobel Prize. Driven by a passion to understand how nature works and to turn discoveries into inventions, Doudna has become a leader in the scientific field, often wrestling with the moral issues that arise from her discovery. Join us as Walter Isaacson traces a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species. NOTES Want to attend this program for free? Join today at the Monthly Sustaining Membership level and receive a special discount code to use at check out. If you are already a member, please log in to receive your $5 general admission ticket. Discounts will automatically be applied during check out. Copies of The Code Breaker are available for purchase. Purchased books will be sent to the address provided at checkout (domestic U.S. addresses only). Part of our Good Lit series, underwritten by the Bernard Osher Foundation. This program is done in association with Wonderfest. SPEAKERS Walter Isaacson Professor of History, Tulane University, Former CEO, Aspen Institute, Author, The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race In Conversation with Kishore Hari Strategic Partnerships, Science Communications and Engagement, Chan Zuckerberg Initiative In response to the COVID-19 pandemic, we are currently hosting all of our live programming via YouTube live stream. This program was recorded via video conference on March 17th, 2021 by the Commonwealth Club of California. Learn more about your ad choices. Visit megaphone.fm/adchoices
0:00 Заслуживает ли Sony биографии от Уолтера Айзексона5:01 Зарождение капитализма в Японии 8:50 Первые годы Sony в послевоенной разрухе 11:20 Что изобрести первым японцу?13:30 Магнитофон весом 35 килограмм17:02 Как появилось название Sony18:33 В Sony Walkman никто не верил 22:48 Закат Sony24:45 Американец во главе японской компании29:07 "Продавайте Sony", начало возрождения Sony 31:20 Sony сегодня - огромный конгломерат38:20 Почему Sony стоит дешевле, чем сумма ее частей 44:14 Дорого ли стоит Sony?52:24 О потребительском секторе США Упоминания Трещина в мироздании | Даудна Дженнифер, Стернберг Сэмюэльhttps://www.ozon.ru/context/detail/id/161810352/ The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Racehttps://www.amazon.com/gp/product/B08G1XNG7J/ref=dbs_a_def_rwt_hsch_vapi_tkin_p1_i0 Sony. Сделано в Японии | Морита Акиоhttps://www.ozon.ru/context/detail/id/2746442/ Обзор Bastion по Sony https://boosty.to/bastion/posts/386a221d-28a1-498a-b0e4-d17f9e40a55b
In this episode, we have one of my Bucket List's guests, author Walter Isaacson. He is the best biographer out there, and he wrote classic biographies of Steve Jobs, Albert Einstein, Leonardo Da Vinci, and more. This time, Walter Issacson and I discussed his new book, The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. Gene editing is probably one of the areas of science that will change all life, all society, the way we think about society and life! We also talked about the gene-editing company, CRISPR, and the ethics behind editing gene and the dilemma that come with it! My new book Skip The Line is out! Make sure you get a copy wherever you get your new book! Join You Should Run For President 2.0 Facebook Group, and we discuss why should run for president. I write about all my podcasts! Check out the full post and learn what I learned at jamesaltucher.com/podcast. Thanks so much for listening! If you like this episode, please subscribe to "The James Altucher Show" and rate and review wherever you get your podcasts: Apple Podcasts Stitcher iHeart Radio Spotify Follow me on Social Media: YouTube Twitter Facebook ------------What do YOU think of the show? Head to JamesAltucherShow.com/listeners and fill out a short survey that will help us better tailor the podcast to our audience!Are you interested in getting direct answers from James about your question on a podcast? Go to JamesAltucherShow.com/AskAltucher and send in your questions to be answered on the air!------------Visit Notepd.com to read our idea lists & sign up to create your own!My new book, Skip the Line, is out! Make sure you get a copy wherever books are sold!Join the You Should Run for President 2.0 Facebook Group, where we discuss why you should run for President.I write about all my podcasts! Check out the full post and learn what I learned at jamesaltuchershow.com------------Thank you so much for listening! If you like this episode, please rate, review, and subscribe to "The James Altucher Show" wherever you get your podcasts: Apple PodcastsiHeart RadioSpotifyFollow me on social media:YouTubeTwitterFacebookLinkedIn