Podcasts about immunopathology

In this episode, we delve into the remarkable benefits of colostrum and how it can support hormone balance across various stages of a woman's life. From improving period health to promoting a healthy pregnancy, aiding postpartum recovery, and regulating hormones during perimenopause, colostrum's nutrient-rich properties make it an effective tool for women seeking natural solutions. We'll discuss how colostrum works at the cellular level, with scientific insights on its anti-inflammatory effects, gut health benefits, and hormone-regulating capabilities. Berri's Favorite Colostrum & Save with Code: BERRION Key Topics Discussed: 1. How Colostrum Improves Period Health Gut Barrier Repair: Colostrum contains growth factors like IGF-1 and TGF-β that aid in repairing the gut lining, preventing "leaky gut." A healthy gut helps metabolize and eliminate excess hormones, reducing PMS symptoms. Reducing Inflammation: Anti-inflammatory compounds like lactoferrin decrease inflammation, alleviating menstrual cramps and pelvic pain. Enhancing Nutrient Absorption: Colostrum supports better absorption of magnesium and vitamin B6, which are essential for mood stability and reducing PMS symptoms. 2. Colostrum's Role in Promoting a Healthy Pregnancy Immune Modulation: Immunoglobulins in colostrum help balance the immune response, protecting the mother and developing baby from pathogens without causing excessive inflammation. Nutrient Absorption: Supports the growth of beneficial gut bacteria to enhance absorption of vital nutrients like calcium, iron, and folate, crucial for fetal development. Growth Factors for Fetal Development: Contributes to the development of essential organs, such as the lungs and gut, potentially reducing the risk of preterm birth. 3. Easing Postpartum Recovery with Colostrum Tissue Healing: Growth factors aid in repairing tissues affected by childbirth, speeding up recovery. Hormone Metabolism and Mood Stability: Supports the breakdown and elimination of excess hormones, helping stabilize hormone levels post-delivery. Immune Support: Boosts immunity with compounds like lactoferrin, enhancing the body's defense against infections during the postpartum period. 4. Regulating Hormones During Perimenopause Improving Insulin Sensitivity: Helps stabilize blood sugar levels by improving insulin sensitivity, which can alleviate fatigue and irritability. Gut Health and Hormone Detoxification: Assists in the elimination of hormones like estrogen, reducing symptoms of estrogen dominance. Anti-Aging and Tissue Repair: Supports tissue regeneration, countering symptoms associated with aging, such as thinning skin or joint discomfort. Episode Highlights: Colostrum's Unique Nutrients: Why this pre-milk fluid is more than just a newborn's first food. Scientific Evidence: Insights from studies on colostrum's role in inflammation, gut health, and hormonal balance. Practical Tips: How to incorporate high-quality colostrum supplements into your routine. Resources Mentioned: Studies cited from journals such as Reproductive Biology and Endocrinology, Journal of Obstetrics and Gynaecology, and International Journal of Immunopathology and Pharmacology.

Pour accéder à l'intégralité de ce podcast et écouter chaque semaine un nouvel épisode du Quart d'Heure Véto, c'est très simple, il vous suffit de vous abonner en cliquant sur ce lien : https://m.audiomeans.fr/s/S-yUNSBZSR Notes et références Article helley Turner, Heather K. Knych, Amanda A. Adams, "The effects of cannabidiol on immune function and health parameters in senior horses", Veterinary Immunology and Immunopathology, Volume 257, 2023, 110549, ISSN 0165-2427, https://doi.org/10.1016/j.vetimm.2023.110549 Retrouvez toute la synthèse sur la fiche podcast juste ici : https://audmns.com/ENFvleh Pour nous suivre : 1. Abonnez-vous à notre chaine pour profiter de l'intégralité des épisodes : Le Quart d'Heure Véto : décrypte et résume en moins de 15 min un article de biblio véto - Sur abonnement uniquement Le Véto du Mois : Partagez le temps d'une interview l'expérience de vétérinaires emblématiques de notre milieu, des rencontres conviviales, comme si nous étions dans votre salon au coin du feu. Podcasts bonus au fil des inspirations... 2. Le Scope Nous partageons avec vous nos dernières découvertes, inspirations, pistes de réflexion, nouveautés… À découvrir et utiliser dès maintenant, TOUT DE SUITE, dans votre quotidien de vétérinaire, de manager, de vie personnelle, de chef d'entreprise… Et tout cela en moins de 5 minutes top chrono un à 2 mardis par mois ! Je souhaite recevoir mon Scope : https://vetmasterclass.com/lescope/ 3. Contactez-nous, suivez-nous et donnez nous votre avis ! Des sujets que vous souhaiteriez approfondir, des références à partager, ou nous faire part de vos feed-backs : Abonnez-vous à notre chaine, donnez nous des étoiles, un commentaire et partagez autour de vous ! Sur notre site : https://vetmasterclass.com/ Sur Facebook : https://www.facebook.com/VmHorse Sur Instagram : https://www.instagram.com/vetmasterclass/ Sur YouTube : https://www.youtube.com/channel/UC18ovcWk9e-mFiTL34OQ03g Sur Linkedin : https://www.linkedin.com/company/vetmasterclass-horse/about/ Belle journée à tous, Et continuez à vivre votre métier avec Passion !

In this conversation, Vivian Pinn speaks with Robert Winn, guest editor of The Cancer Letter and the Cancer History Project during Black History Month, about the obstacles she faced as a medical student, how she incidentally helped integrate restaurants in Charlottesville in the 1960s, and her beginnings as a Research Fellow in Immunopathology at NIH. Pinn was the only African American and the only woman in her class to graduate from the University of Virginia School of Medicine in 1967. In 1982, she was the first African American woman to chair an academic pathology department in the United States, at Howard University College of Medicine. She went on to become the first full-time director of the Office of Research on Women's Health at NIH in 1991.

There has been a major shift in awareness in the importance of our body's immune system in overall well-being. This episode combines both knowledge and practice on how to manage, care, and support wellness for those seeking optimal balance and control of their immune biology. Our guest is Professor Patrick Bouic, a Professor of Immunopathology, who is regarded as one of the world's leading experts on the immune system. In 1996, he first demonstrated the immune balancing power of plant sterols and sterolins, with a paper published in the acclaimed Journal of Immunopharmacology. He became a passionate advocate for plant sterols and sterolins as a result of his ongoing research and his own family's experience. More at www.preparedimmune.com 

References J Immunol. 2018 Feb 1; 200(3): 915–927 Cells. 2020 Jan; 9(1): 198. Cells. 2022 Apr; 11(7): 1105 Nature Comm. 2020. volume 11, Article number: 35 Schubert F. 1829. Fantasie in F minor. D940 https://youtu.be/UyjzqPPXDcw?si=XW_SMP7j-Kza8pmq Winwood, Capaldi and Wood. 1967 (Traffic). "Dear Mr Fantasy" https://youtu.be/dyMiUmrouZU?si=1ZSdXupm3WFBAxTz --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

In this podcast, expert clinicians will review the underlying immunopathology and various clinical presentations of EGPA and discuss its impact on patient quality of life.

The window is closing to stop the spread of Monkeypox -- scientists advising the World Organisation are warning. While the majority of experts voted against declaring the outbreak an emergency, in an unprecedented move they were overruled by the WHO's director general. Is Monkeypox an emergency and can we stop the spread? GUESTS: Oyewale Tomori Professor of Virology at the Redeemer's University Ede Emilia Skirmuntt Evolutionary Virologist at University of Oxford Vaccine Group Neil Mabbott Professor of Immunopathology at the University of Edinburgh Roundtable is a discussion program with an edge. Broadcast out of London and presented by David Foster, it's about bringing people to the table, listening to every opinion, and analysing every point of view. From fierce debate to reflective thinking, Roundtable discussions offer a different perspective on the issues that matter to you. Watch it every weekday at 15:30 GMT on TRT World.

Korea24 – 2022.02.02. (Wednesday) News Briefing: The daily COVID-19 case count in South Korea surpassed 20-thousand for the first time since the outbreak of the pandemic. Despite the spike in infections, the number of critically ill patients only edged up by six from the previous day to 278. (Thomas MCCARTHY) In-Depth News Analysis: The European director of the World Health Organization, Hans Kluge, recently stated that the COVID-19 pandemic has entered a new phase with the Omicron variant and that it could eventually bring the pandemic to an end. Meanwhile, a new subvariant of Omicron, labeled BA.2, or “stealth” omicron, has emerged. It has already been reported in some 50 countries, including the UK and South Korea. For analysis on these developments, Professor Neil Mabbott, Chair of Immunopathology at the University of Edinburgh, joins us on the line. Understanding Seollal with Walter Lee: In the second of our two-part series delving into the history and traditions surrounding Seollal (설날), or the Lunar New Year Holiday, Walter introduces us to traditional games enjoyed during this period, including ‘yut nori’ and kite-flying, as well as a song closely associated with the holiday. Korea Book Club: Our pick this week is 'Puy, Thuy, Whatever' (쁘이거나 쯔이거나) by Paik Ga-huim (백가흠), a short story that offers a powerful social commentary on the issue of mail-order brides in South Korea. It tells the story of a young Vietnamese woman who arrives in Korea and is abused and mistreated by her new husband and family. Our literary critic Barry Welsh joins us on the line to offer his thoughts.

Episode 34: Dr. Andrew Katelaris - A Different Point of View Dr. Andrew Katelaris graduated from Sydney University with a Bachelor of Medicine in 1982 and was awarded a Doctorate in Medicine in Immunopathology in 1992. He has over twenty years of experience in clinical medicine, forensic pathology and medical research. Dr. Katelaris has also been a vocal advocate for the medicinal use of marijuana in Australia and could be considered a pioneer in this field. Like many medical Doctors from around the world, Dr. Katelaris has been voicing his concerns about the handling of the current pandemic. In this podcast, Dr. Katelaris puts forward a number of through provoking topics of discussion and highlights some uncomfortable truths. It's also interesting to hear Dr. Katelaris' thoughts on the "V", given his qualifications in immunology.  Disclaimer: This podcast is for general information purposes only. It does not constitute as health advice and does not take the place of consulting with your primary health care practitioner. The views and opinions expressed in this podcast are those of the guest speaker and do not necessarily reflect those of Humanley, the presenter or any other entities or third parties associated with Humanley or the presenter. The right to freedom of opinion is the right to hold opinions without interference, and cannot be subject to any exception or restriction. We encourage the audience to use their critical judgement and use due diligence when interpreting the information and topics discussed in this podcast.     

Magnesium is essential for the immune system, including in the fight against cancer University of Basel (Switzerland), January 19, 2022 Previous studies have shown that cancerous growths spread faster in the bodies of mice when the animals received a low-magnesium diet – and that their defense against flu viruses was also impaired. However, there has so far been little research into how exactly this mineral affects the immune system. Now, researchers have discovered that T cells can eliminate abnormal or infected cells efficiently only in a magnesium-rich environment. Specifically, magnesium is important for the function of a T cell surface protein called LFA-1. (NEXT) More lycopene linked to longer lives for people with metabolic syndrome University of Nebraska Medical Center, January 16, 2022 Higher blood levels of lycopene may reduce the risk of mortality in people with metabolic syndrome, says a new study from the University of Nebraska Medical Center. Lycopene is an antioxidant that is present in red- and pink-colored fruits and vegetables. As well as being used as a food coloring, it is also used in supplements and functional foods and beverages. New data published in Nutrition Research suggests that higher serum levels of lycopene were associated with greater survival times for people with metabolic syndrome, compared to low serum levels. (NEXT) Too much sugar during adolescence may alter brain's reward circuits European Journal of Neuroscience, January 19, 2022 A new study in rats may provide significant insights into the long-term impacts of over-consumption of sugary foods during adolescence. The study shows that the enjoyment of such foods later in adulthood is reduced in those who over-consumed early in life. Investigators found that this decrease in reward relates to reduced activity in one of the key hubs of the brain's reward circuitry, called the nucleus accumbens. Such long-lasting alterations could have important implications for reward-related disorders such as substance abuse or eating disorders. (NEXT) Unveiled the epigenetic mechanism by which vitamin D modulates the tolerance of the immune system Josep Carreras Leukaemia Research Institute (Germany), January 19, 2022 In autoimmunity, the mechanisms that guarantee that our defense system does not attack our own body - tolerance to oneself - does not work properly. Multiple sclerosis, which affects one in every 1,000 people in Spain, is a serious autoimmune disease in which the immune system attacks the myelin sheath of some types of neurons, causing progressive neurological disability. Dr. Esteban Ballestar, leader of the Epigenetics and immune diseases group at the Josep Carrreras Leukaemia Research Institute, and Dr. Eva Martínez-Cáceres, leader of the Immunopathology group at the IGTP-Hospital Germans Trias i Pujol, have recently published in the prestigious journal Cell Reports the mechanism by which vitamin D activates the tolerance program of dendritic cells. (NEXT) Study links poor sleep in seniors to more severe arteriosclerosis University of Toronto, January 19, 2022 Poor sleep quality in older people is associated with more severe arteriosclerosis in the brain as well as a greater burden of oxygen-starved tissue (infarcts) in the brain, both of which can contribute to the risk of stroke and cognitive impairment, according to the newest findings reported in the American Heart Association's journal Stroke. The relationship between cardiovascular disease and so-called "fragmented" sleep has been studied in the past, but this is the first study to look specifically for an association between sleep fragmentation and detailed microscopic measures of blood vessel damage and infarcts in autopsied brain tissue from the same individuals. Fragmented sleep occurs when sleep is interrupted by repeated awakenings or arousals. In this study, sleep was disrupted on average almost seven times per hour. Researchers found that greater sleep fragmentation was associated with 27 percent higher odds of having severe arteriosclerosis. Moreover, for each additional two arousals during one hour of sleep, researchers reported a 30 percent increase in the odds that subjects had visible signs of oxygen deprivation in their brain. (OTHER NEWS) America's New Class War Chris Hedges, January 18, 2022 There is one last hope for the United States. It does not lie in the ballot box. It lies in the union organizing and strikes by workers at Amazon, Starbucks, Uber, Lyft, John Deere, Kellogg, the Special Metals plant in Huntington, West Virginia, owned by Berkshire Hathaway, the Northwest Carpenters Union, Kroger, teachers in Chicago, West Virginia, Oklahoma and Arizona, fast-food workers, hundreds of nurses in Worcester, Massachusetts, and the members of the International Alliance of Theatrical Stage Employees. Organized workers, often defying their timid union leadership, are on the march across the United States. Over four million workers, about 3% of the work force, mostly from accommodation and food services, healthcare and social assistance, transportation, housing, and utilities have walked away from jobs, rejecting poor pay along with punishing and risky working conditions. There is a growing consensus – 68% in a recent Gallup poll with that number climbing to 77% of those between the ages of 18 and 34 – that the only way left to alter the balance of power and force concessions from the ruling capitalist class is to mobilize and strike, although only 9% of the U.S. work force is unionized. Forget the woke Democrats. This is a class war. The Democratic Party will not push through the kind of radical New Deal reforms that in the 1930s staved off fascism and communism. Its empty political theater, which stretches back to the Clinton administration, was on full display in Atlanta when Biden called for revoking the filibuster to pass the Freedom to Vote Act and the John Lewis Voting Rights Advancement Act, knowing that his chances of success are zero. Georgia Democratic gubernatorial candidate Stacey Abrams, along with several of the state's voting rights groups, boycotted the event in a very public rebuke. They were acutely aware of Biden's cynical ploy. When the Democrats were in the minority, they clung to the filibuster like a life raft. Then Sen. Barack Obama, along with other Democrats, campaigned for it to remain in place. And a few days ago, the Democratic leadership employed the filibuster to block legislation proposed by Sen. Ted Cruz. The Democrats have been full partners in the dismantling of our democracy, refusing to banish dark and corporate money from the electoral process and governing, as Obama did, through presidential executive actions, agency “guidance,” notices and other regulatory dark matter that bypass Congress. The Democrats, who helped launch and perpetuate our endless wars, were also co-architects of trade deals such as NAFTA, expanded surveillance of citizens, militarized police, the largest prison system in the world and a raft of anti-terrorism laws such as Special Administrative Measures (SAMs) that abolish nearly all rights, including due process and attorney-client privilege, to allow suspects to be convicted and imprisoned with secret evidence they and their lawyers are not permitted to see. The squandering of staggering resources to the military — $777.7 billion a year — passed in the Senate with an 89-10 vote and in the House of Representatives with a 363-70 vote, coupled with the $80 billion spent annually on the intelligence agencies has made the military and the intelligence services, many run by private contractors such as Booz Allen Hamilton, nearly omnipotent. The Democrats long ago walked out on workers and unions. The Democratic governor of Maine, Janet Mills, for example, killed a bill a few days ago that would have allowed farm workers in the state to unionize. On all the major structural issues there is no difference between the Republicans and the Democrats. The longer the Democratic Party does not deliver real reforms to ameliorate the economic hardship, exacerbated by soaring inflation rates, the more it feeds the frustration of many of its supporters, widespread apathy (there are 80 million eligible voters, a third of the electorate, who do not cast ballots) and the hatred of the “liberal” elites stoked by Donald Trump's cultish Republican Party. Its signature infrastructure package, Build Back Better, when you read the fine print, is yet another infusion of billions of government money into corporate bank accounts. This should not surprise anyone, given who funds and controls the Democratic Party. The rapacious pillage by the elites, many of whom bankroll the Democratic Party, has accelerated since the financial crash of 2008 and the pandemic. Wall Street banks recorded record profits for 2021. As the Financial Times noted, they milked the underwriting fees from Fed-based borrowing and profited from mergers and acquisitions. They have pumped their profits, fueled by roughly $5 trillion in Fed spending since the beginning of the pandemic, as Matt Taibbi points out, into massive pay bonuses and stock buybacks. “The bulk of this new wealth—most—is being converted into compensation for a handful of executives,” Taibbi writes. “Buybacks have also been rampant in defense, pharmaceuticals, and oil & gas, all of which also just finished their second straight year of record, skyrocketing profits. We're now up to about 745 billionaires in the U.S., who've collectively seen their net worth grow about $2.1 trillion to $5 trillion since March 2020, with almost all that wealth increase tied to the Fed's ballooning balance sheet.” Kroger is typical. The corporation, which operates some 2,800 stores under different brands, including Baker's, City Market, Dillons, Food 4 Less, Foods Co., Fred Meyer, Fry's, Gerbes, Jay C Food Store, King Soopers, Mariano's, Metro Market, Pay-Less Super Markets, Pick'n Save, QFC, Ralphs, Ruler and Smith's Food and Drug, earned $4.1 billion in profits in 2020. By the end of the third quarter of 2021, it had $2.28 billion in cash, an increase of $399 million in the first quarter of 2020. Kroger CEO Rodney McMullen made over $22 million, nearly doubling the $12 million he made in 2018. This is over 900 times the salary of the average Kroger worker. Kroger in the first three quarters of 2021 also spent an estimated $1.3 billion on stock buybacks. Class struggle defines most of human history. Marx got this right. It is not a new story. The rich, throughout history, have found ways to subjugate and re-subjugate the masses. And the masses, throughout history, have cyclically awoken to throw off their chains. (NEXT) Was Peter Daszak Working For The Central Intelligence Agency? Kanekoa, January 18, 2022 “We found other coronaviruses in bats, a whole host of them, some of them looked very similar to SARS. So we sequenced the spike protein: the protein that attaches to cells. Then we… Well, I didn't do this work, but my colleagues in China did the work. You create pseudo particles, you insert the spike proteins from those viruses, see if they bind to human cells. At each step of this, you move closer and closer to this virus could really become pathogenic in people. You end up with a small number of viruses that really do look like killers." This statement was said by EcoHealth Alliance President Peter Daszak at a 2016 forum discussing “emerging infectious diseases and the next pandemic”. Daszak, who received more than $118 million in grants and contracts from federal agencies, including $53 million from USAID, $42 million from DOD, and $15 million from HHS, appeared to boast about the manipulation of “killer” SARS-like coronaviruses carried out by his “colleagues in China” at the now infamous Wuhan Institute of Virology. According to investigative research done by independent-journalist Sam Husseini and The Intercept, much of the money awarded to EcoHealth Alliance did not focus on health or ecology, but rather on biowarfare, bioterrorism, and other dangerous uses of deadly pathogens. EcoHealth Alliance received the majority of its funding from the United States Agency for International Development (USAID), a State Department subsidiary that serves as a frequent cover for the Central Intelligence Agency (CIA). Their second largest source of funding was from the Defense Threat Reduction Agency (DTRA), which is a branch of the Department of Defense (DOD) which states it is tasked to “counter and deter weapons of mass destruction and improvised threat networks.” The United States Agency for International Development (USAID) has a long history of acting as a contract vehicle for various CIA covert activities. With an annual budget of over $27 billion and operations in over 100 countries, one former USAID director, John Gilligan, once admitted it was “infiltrated from top to bottom with CIA people.” Gilligan explained that “the idea was to plant operatives in every kind of activity we had overseas; government, volunteer, religious, every kind.” From 2009 to 2019, USAID partnered with EcoHealth Alliance on their PREDICT program which identified over 1,200 new viruses, including over 160 coronavirus strains; trained roughly 5,000 people around the world to identify new diseases; and improved or developed 60 research laboratories. What better way for the CIA to collect intelligence on the world's biological warfare capabilities? Dr. Andrew Huff received his Ph.D. in Environmental Health specializing in emerging diseases before becoming an Associate Vice President at EcoHealth Alliance, where he developed novel methods of bio-surveillance, data analytics, and visualization for disease detection. On January 12, 2022, Dr. Andrew Huff issued a public statement (on Twitter) in which he claimed, Peter Daszak, the President of EcoHealth Alliance, told him that he was working for the CIA. Dr. Huff continued, “…I wouldn't be surprised if the CIA / IC community orchestrated the COVID coverup acting as an intermediary between Fauci, Collins, Daszak, Baric, and many others. At best, it was the biggest criminal conspiracy in US history by bureaucrats or political appointees.” In February 2020, Daszak told University of North Carolina coronavirus researcher Dr. Ralph Baric that they should not sign the statement condemning the lab-leak theory so that it seems more independent and credible. “You, me and him should not sign this statement, so it has some distance from us and therefore doesn't work in a counterproductive way,” Daszak wrote. More unredacted emails have revealed that while these scientists held the private belief that the lab release was the most likely scenario, they still worked to seed the natural origin narrative for the public through the papers published in Nature Medicineand The Lancet. If Dr. Andrew Huff is telling the truth, Fauci, Collins, and Daszak might be covering up the lab origin not only for themselves, but also for the Central Intelligence Agency, the Department of Defense, and the U.S. Government.

Céline Gounder is Clinical Assistant Professor of Medicine at New York University School of Medicine and Attending Physician at Bellevue Hospital Center, New York, USA. She hosts the podcasts “American Diagnosis” and “Epidemic” and is CEO and Founder of Just Human Productions. She can be found on Twitter at @celinegounder.Michael Shurin is Director of the Division of Clinical Immunopathology and Associate Professor of Pathology and Immunology at the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. 

Reverse MCQs for Immunopathology - USMLE Step 1

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Keep CoV off campus (NY Times) Inflammatory cytokines predict COVID-19 death (medRxiv) Imbalanced host response drives COVID-19 (Cell) Convergent antibody responses in COVID-19 patients (bioRxiv) Cross neutralization of SARS-CoV-2 by SARS-CoV mAb (Nature) Human T-cell responses to SARS-CoV-2 (Cell) DNA vaccine protects rhesus macaques (Science) Replicon RNA vaccine protects macaques (bioRxiv) Letters read on Immune 32 Image credit Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is a rare form of vasculitis that primarily affects the small blood vessels. Individuals diagnosed with EGPA commonly have a history of asthma and/or allergies. Inflammation associated with EGPA can lead to injury in multiple organ systems, including the sinuses, lungs, gastrointestinal system, heart, and kidneys. Early diagnosis and treatment are critical when managing EGPA to improve patient outcomes and reduce symptom burden. Education is needed to provide clinicians with the latest information regarding optimal diagnostic and management strategies, including newer steroid-sparing therapy options. In this CME podcast series, experts will provide guidance on differentiating EGPA from related vasculitides or eosinophilic conditions, highlight recent clinical data, and discuss therapeutic advancements. Transcript available here: https://tinyurl.com/EGPA1

Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode ACE2 in oral mucosa (I J Oral Sci) IL6 predictor of COVID-19 death (Int Care Med) Protective immunity to SARS-CoV-2 in nonhuman primates (bioRxiv) Antibody to SARS-CoV wanes (J Immunol) Image credit Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

I'm a huge fan of training outdoors, regardless of whether it's hot or cold. There are a number of reasons I personally like it, but today I want to talk about why you should be incorporating it into your own routine. You get some quality natural sunlight and some added Vitamin D. I’m deficient and I’m outside all the time and I know it's an issue for many men. Plus, it improves sleep and fights off depression. Solitude. Being outdoors alone improves concentration and increases productivity. It also helps you work through problems more effectively and allows you to reboot your brain and unwind. It's fun. Enjoying your workouts is critical for long-term success. Consistency is key and if you don't like what you're doing, you won't stick to it for long. It allows you to get creative with your workouts. Family time. Try hitting the park with your kids and turn your workout into family time. Involve them. Let them have fun. Get you out of the artificial environment. We're in cars, cubicles, and gyms all the time and it's filled with artificial lights (and smells). It's good for the soul. I'm not a spiritual guy, but you can't not feel good when you're outside training. Time Efficient. The #1 excuse I hear why so many of you aren’t fit is a lack of time. Outdoor training is non conventional and you can get an amazing workout in 20 minutes or less. Plus, no waiting for machines and no commutes. You probably have a park within walking distance. Many of the workouts I do in the Inner Circle are 15-20 minutes and they work very well. Boosts your mood and energy. We all can benefit from this. No equipment needed. Bodyweight training works great for building strength, losing fat, and getting fit. I like to bring a suspension trainer, tire sled, or sandbag sometimes, but those are optional. Immune system boost. A study in the International Journal of Immunopathology found that breathing in small amounts of airborne plant chemicals improves your immune responses by 50%. Breaks up your routine and monotony. Getting your butt outside is a great way to avoid ruts. Muscle confusion. Yes, it's good to mix up your workouts (to a point) and training outside like at a park will work muscles you haven't felt in years. Challenging terrain. Training on grass, rocks, sand, diet, etc. will challenge you in a way that can't be done in a gym. You'll work on ankle stability while your training and running hill sprints is one of the best exercises you can do. It's FREE! Yes, you can get into amazing shape without spending a dime on gym memberships or fancy equipment. A park has enough bars, ropes, swings, platforms, and benches to work every muscle in your body. You just need to get creative. In the Fit Dad Nation Inner Circle, we have a huge library of outdoor workouts for you to use and it's growing by the week! Join the brotherhood at fitdadnation.com/innercircle  

What is an effective way to begin conversations about diet and nutrition discussions in a health care setting? This episode serves as a foundation for future podcasts, including important general concepts to keep in mind for all nutrition counseling. Articles/references: Claire P. Kelley, PsyDa, *, Geena Sbrocco, MS, RDb,c , Tracy Sbrocco, PhDa, Behavioral Modification for the Management of Obesity Dietary Guidelines for Americans. 08/08/2018; Available from: https://health.gov/dietaryguidelines/. Aspry, K.E., et al., Medical Nutrition Education, Training, and Competencies to Advance Guideline-Based Diet Counseling by Physicians A Science Advisory From the American Heart Association. Circulation, 2018. 137(23): p. E821-E841. Brook, R.D. and S. Rajagopalan, 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal of the American Society of Hypertension, 2018. 12(3): p. 238-238. Tete, S., et al., Nutrition and Cancer Prevention. International Journal of Immunopathology and Pharmacology, 2012. 25(3): p. 573-581. Goldstein, L.B., et al., Guidelines for the Primary Prevention of Stroke A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke, 2011. 42(2): p. 517-584. Sami, W., et al., Effect of diet on type 2 diabetes mellitus: A review. International Journal of Health Sciences-Ijhs, 2017. 11(2). Evert, A.B., et al., Nutrition Therapy Recommendations for the Management of Adults With Diabetes. Diabetes Care, 2014. 37: p. S120-S143. Garvey, W.T., et al., American Association of Clinical Endocrinologists and American College of Endocrinology Position Statement on the 2014 Advanced Framework for a New Diagnosis of Obesity as a Chronic Disease. Endocrine Practice, 2014. 20(9): p. 977-989. Jellinger, P.S., et al., American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for Management of Dyslipidemia and Prevention of Cardiovascular Disease - Executive Summary. Endocrine Practice, 2017. 23(4): p. 479-497.

The Beacons of Viral Education (aka the TWiVoners) reveal a cost of being a male mouse - the Y chromosome regulates their susceptibility to influenza virus infection. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler   Become a patron of TWiV! Links for this episode ASM Grant Writing Online Course Giant viruses not from fourth domain of life (Virology) Nuclear envelope disruption during parvovirus infection (J Virol) Nuclear deformation during SV40 infection (Nucleus) Y chromosome regulates mouse susceptibility to influenza virus (PNAS) Consomic strains (Mamm Genome) Giants among viruses (TWiV 261) Image credit Letters read on TWiV 441 Weekly Science Picks Kathy - Social science research on “luck” in motherhood Alan - Foiling dinghy built by engineering students (video) Rich - Human Exploration Research Analog (HERA) Vincent - Make measles great again in Michigan and Which tech giant would you drop? Listener Pick Steven - Difficult truths about a post-truth world Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contribute to alphavirus pathogenesis. Links for this episode IL10 modulation of Th17 cells during alphavirus pathogenesis (PNAS) Th17 cells involved in influenza mediated gut injury (J Exp Med) Helper T cells 2014-15 flu season (CDC) Key facts about flu & flu vaccine (CDC) Does the flu vaccine work? (Turbid plaque) Effectiveness of flu vaccine (virology blog) Image credit Letters read on TWiV 316 Weekly Science Picks Alan - It came from the pondRich - WanderersKathy - The Sense of Style by Steven PinkerVincent - Life in Our Phage World Listener Pick of the Week Fernando - Reality based? Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Most kidney disorders involve some degree of inflammation, i.e. induction of pro-inflammatory mediators and leukocyte recruitment. But what are the factors that determine inflammation as a trigger or a consequence of kidney injury? Which types of renal inflammation can be targeted by the novel more selective immunosuppressive and anti-inflammatory agents? How to dissect the mechanisms behind innate and adaptive immune responses that are orchestrated inside or outside the kidney but both cause renal immunopathology i.e. renal inflammation? How to dissect leukocytic cell infiltrates into pro-inflammatory leukocytes from anti-inflammatory and pro-regenerative leukocytes? How to dissect leukocytes that support epithelial repair from those that promote renal fibrosis. The term `renal inflammation' has moved far beyond the descriptive category of `mixed leukocytic cell infiltrates' as commonly described in kidney biopsies. It is time to face the complexity of renal inflammation to finally benefit from the new age of novel immunomodulatory medicines.

Dr Kerstin Luhn talks about her research on Dengue infection. Dengue is a major public health problem in the tropics, with around 100 million cases each year. Dr Kerstin Luhn is investigating the effect of Dengue virus infection on innate immune cells to understand why Dengue, unlike other viral infections, is associated with high levels of immunopathology. An in vitro Dengue model is used and results are confirmed with Dengue patient samples from a cohort in Vietnam. This work may lead to future anti-viral treatments or vaccines.

Dr Kerstin Luhn talks about her research on Dengue infection. Dr Luhn is investigating the effect of Dengue virus infection on innate immune cells to understand why Dengue, unlike other viral infections, is associated with high levels of immunopathology. An in vitro Dengue model is used and results are confirmed with Dengue patient samples from a cohort in Vietnam.

Dr Kerstin Luhn talks about her research on Dengue infection. Dengue is a major public health problem in the tropics, with around 100 million cases each year. Dr Kerstin Luhn is investigating the effect of Dengue virus infection on innate immune cells to understand why Dengue, unlike other viral infections, is associated with high levels of immunopathology. An in vitro Dengue model is used and results are confirmed with Dengue patient samples from a cohort in Vietnam. This work may lead to future anti-viral treatments or vaccines.

Dr Kerstin Luhn talks about her research on Dengue infection. Dr Luhn is investigating the effect of Dengue virus infection on innate immune cells to understand why Dengue, unlike other viral infections, is associated with high levels of immunopathology. An in vitro Dengue model is used and results are confirmed with Dengue patient samples from a cohort in Vietnam.