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Effy sits down with Jackie Buckalew of The Callous Daoboys.Follow Jackie on instagramAnd listen to The Callous Daoboys---See Effy6/26 - Freelance Wrestling – Chicago, IL6/27 - Blitzkrieg Pro - Enfield, CT6/29 - Produce Wrestling - Brooklyn, NY7/16 - Produce Wrestling - White Eagle Hall, NJ 7/18-19 TWE - Cattanooga, TN7/25 - NWA 78 - Philadelphia, PA7/26 - Glory Pro - St. Louis, MI---Get early episodes, bonus minisodes, merch discounts, Effy video blogs, puppy content and weather reports in the Pleasure Zone.Sponsor the podcast: weekendateffys@gmail.comSEND EFFY:650 Ponce De Leon Ave Ste. 300# 2936Atlanta, GA 30308Book EFFYWEAR EFFY-----Petár makes stuff too@lowskydance on insta and blueskyetsy shop - hand-painted analog projection art AI Slop Awareness Stickers
Effy is Bumpin' Barbara WaltersPetár is busy (pls follow and like @lowskydance)---See Effy6/19 - After Dark Wrestling - Joliet, IL6/20 - Dreamwave - Joliet, IL6/26 - Freelance Wrestling – Chicago, IL6/27 - Blitzkrieg Pro - Enfield, CT6/29 - Produce Wrestling - Brooklyn, NY7/16 - Produce Wrestling - White Eagle Hall, NJ 7/18-19 TWE - Cattanooga, TN7/25 - NWA 78 - Philadelphia, PA7/26 - Glory Pro - St. Louis, MI---Get early episodes, bonus minisodes, merch discounts, Effy video blogs, puppy content and weather reports in the Pleasure Zone.Sponsor the podcast: weekendateffys@gmail.comSEND EFFY:650 Ponce De Leon Ave Ste. 300# 2936Atlanta, GA 30308Book EFFYWEAR EFFY-----Petár makes stuff too@lowskydance on insta and blueskyetsy shop - hand-painted analog projection art AI Slop Awareness Stickers
Effy sits down with Nathan Mowery, filmmaker, professional wrestler, and stunt man. Follow Nathan:YoutubeInsta---See Effy:6/6 - NWA Hard Times 6 - Atlanta, GA6/13 – Razor Pro Wrestling - Eureka Springs, AR 6/14 - Death in the Family - Austin, TX 6/19 - After Dark Wrestling - Joliet, IL6/20 - Dreamwave - Joliet, IL6/26 - Freelance Wrestling – Chicago, IL6/27 - Blitzkrieg Pro - Enfield, CT6/29 - Produce Wrestling - Brooklyn, NY7/11 - Hybrid Wrestling - Dunnville, Ontario, Canada 7/16 - Produce Wrestling - White Eagle Hall, NJ ---Get early episodes, bonus minisodes, merch discounts, Effy video blogs, puppy content and weather reports in the Pleasure Zone.Sponsor the podcast: weekendateffys@gmail.comSEND EFFY:650 Ponce De Leon Ave Ste. 300# 2936Atlanta, GA 30308Book EFFYWEAR EFFY-----Petár makes stuff too@lowskydance on insta and blueskyetsy shop - hand-painted analog projection art AI Slop Awareness Stickers
Effy sits down with Nathan Mowery (DDP Yoga, Blood and Honey) to talk deathmatch and Jake the Snake. Watch Blood and HoneyFollow Nathan---See Effy:6/13 – Razor Pro Wrestling - Eureka Springs, AR 6/14 - Death in the Family - Austin, TX 6/19 - After Dark Wrestling - Joliet, IL6/20 - Dreamwave - Joliet, IL6/26 - Freelance Wrestling – Chicago, IL6/27 - Blitzkrieg Pro - Enfield, CT6/29 - Produce Wrestling - Brooklyn, NY7/11 - Hybrid Wrestling - Dunnville, Ontario, Canada 7/16 - Produce Wrestling - White Eagle Hall, NJ ---Get early episodes, bonus minisodes, merch discounts, Effy video blogs, puppy content and weather reports in the Pleasure Zone.Sponsor the podcast: weekendateffys@gmail.comSEND EFFY:650 Ponce De Leon Ave Ste. 300# 2936Atlanta, GA 30308Book EFFYWEAR EFFY-----Petár makes stuff too@lowskydance on insta and blueskyetsy shop - hand-painted analog projection art AI Slop Awareness Stickers
Effy sits down with professional wrestler and travel vlogger, Bobby Flaco. This is a wild one, ya'll!Follow Bobby:InstaYoutube---See Effy:6/6 - NWA Hard Times 6 - Atlanta, GA6/13 – Razor Pro Wrestling - Eureka Springs, AR 6/14 - Death in the Family - Austin, TX 6/19 - After Dark Wrestling - Joliet, IL6/20 - Dreamwave - Joliet, IL6/26 - Freelance Wrestling – Chicago, IL6/27 - Blitzkrieg Pro - Enfield, CT6/29 - Produce Wrestling - Brooklyn, NY7/11 - Hybrid Wrestling - Dunnville, Ontario, Canada 7/16 - Produce Wrestling - White Eagle Hall, NJ ---Get early episodes, bonus minisodes, merch discounts, Effy video blogs, puppy content and weather reports in the Pleasure Zone.Sponsor the podcast: weekendateffys@gmail.comSEND EFFY:650 Ponce De Leon Ave Ste. 300# 2936Atlanta, GA 30308Book EFFYWEAR EFFY-----Petár makes stuff too@lowskydance on insta and blueskyetsy shop - hand-painted analog projection art AI Slop Awareness Stickers
This episode is a sneak peak of our ongoing patreon exclusive movie podcast. If you enjoyed this episode, there's plenty more at weekendateffys.com---See Effy:5/22 – Freelance Wrestling – Chicago, IL5/29 – New South Wrestling – Alabama5/30 – Innovative Hybrid Wrestling – Riverview, NB, Canada6/6 - NWA Hard Times 6 - Atlanta, GA6/13 – Razor Pro Wrestling - Eureka Springs, AR 6/14 - Death in the Family - Austin, TX 6/19 - After Dark Wrestling - Joliet, IL6/20 - Dreamwave - Joliet, IL6/26 - Freelance Wrestling – Chicago, IL6/27 - Blitzkrieg Pro - Enfield, CT6/29 - Produce Wrestling - Brooklyn, NY7/11 - Hybrid Wrestling - Dunnville, Ontario, Canada 7/16 - Produce Wrestling - White Eagle Hall, NJ ---Get early episodes, bonus minisodes, merch discounts, Effy video blogs, puppy content and weather reports in the Pleasure Zone.Sponsor the podcast: weekendateffys@gmail.comSEND EFFY:650 Ponce De Leon Ave Ste. 300# 2936Atlanta, GA 30308Book EFFYWEAR EFFY-----Petár makes stuff too@lowskydance on insta and blueskyetsy shop - hand-painted analog projection art AI Slop Awareness Stickers
Effy sits down with his friend Terry Yaki.Follow Terry everywhere:TwitterYoutubeMerch---See Effy:5/22 – Freelance Wrestling – Chicago, IL5/29 – New South Wrestling – Alabama5/30 – Innovative Hybrid Wrestling – Riverview, NB, Canada6/6 - NWA Hard Times 6 - Atlanta, GA6/13 – Razor Pro Wrestling - Eureka Springs, AR 6/14 - Death in the Family - Austin, TX 6/19 - After Dark Wrestling - Joliet, IL6/20 - Dreamwave - Joliet, IL6/26 - Freelance Wrestling – Chicago, IL6/27 - Blitzkrieg Pro - Enfield, CT6/29 - Produce Wrestling - Brooklyn, NY7/11 - Hybrid Wrestling - Dunnville, Ontario, Canada 7/16 - Produce Wrestling - White Eagle Hall, NJ ---Get early episodes, bonus minisodes, merch discounts, Effy video blogs, puppy content and weather reports in the Pleasure Zone.Sponsor the podcast: weekendateffys@gmail.comSEND EFFY:650 Ponce De Leon Ave Ste. 300# 2936Atlanta, GA 30308Book EFFYWEAR EFFY-----Petár makes stuff too@lowskydance on insta and blueskyetsy shop - hand-painted analog projection art AI Slop Awareness Stickers
This episode of the Everyday Epigenetics: Raw. Real. Relatable. podcast takes a hard look at one of the biggest trends in the wellness world: detox culture. Susan Robbins shares a raw and deeply honest perspective on the fear-based messaging surrounding parasites, mold, heavy metals, cleanses, and “toxic overload,” while explaining what true detoxification actually looks like inside the body. From harsh protocols and supplement overload to the nervous system's role in health, this conversation challenges the idea that more detoxing always equals better wellness.Susan also dives into the genetics behind detox pathways, including MTHFR, COMT, PEMT, GST genes, inflammation markers, bile flow, and histamine responses. She explains why personalized health matters, why one-size-fits-all detox programs can backfire, and how stress, sleep, nutrition, circadian rhythm, and emotional safety often play a much bigger role in how the body functions than another cleanse ever will. This episode is a reminder that the body already knows how to detox when it has the right support, nourishment, and stability.In this episode:Why the detox industry often profits from fearThe difference between true toxic overload and depletionHow the body naturally detoxifies through the liver, kidneys, gut, skin, and lymphatic systemWhy harsh cleanses can create more stress on the bodyThe truth about parasite cleanses, binders, colonics, and juice detoxesHow chronic stress impacts detox pathways and hormone balanceWhy genetics like MTHFR, COMT, GST, PEMT, IL6, and TNF-alpha matter in personalized healthThe connection between histamine, sulfur pathways, glutathione, and detox symptomsHow nervous system regulation impacts healing and detoxificationWhy lifestyle rhythms, sleep, meal timing, and stress management matter more than most people realizeHow Susan uses epigenetics and PH360 health types to personalize detox supportThe importance of building resilience instead of living in fear around healthRESOURCES:Find all of Susan's Resources and links in the show notes: Shop the products: http://healthygut.com/healthyawakenings (this link will provide you a special discount!)https://healthyawakening.co/2026/05/18/episode124/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast
Eight U.S. technology companies have signed formal agreements to deploy their frontier AI capabilities on the Defense Department's classified networks “for lawful operational use,” according to a Pentagon press release published Friday. DOD's new deals with SpaceX, OpenAI, Google, NVIDIA, Reflection, Microsoft, Amazon Web Services, and Oracle follow a major contract dispute between the department and Anthropic that culminated earlier this year over potential ethical constraints that accompany the use of AI in warfare and for national surveillance. “Integrating secure frontier AI capabilities into the Department's Impact Level 6 (IL6) and Impact Level 7 (IL7) network environments will streamline data synthesis, elevate situational understanding, and augment warfighter decision-making in complex operational environments,” officials wrote in Friday's press release. A bipartisan congressional push to codify a National Science Foundation-based artificial intelligence research enabler continued this week with the reintroduction in the Senate of the CREATE AI Act. The bill from Sens. Martin Heinrich, D-N.M., Todd Young, R-Ind., Mike Rounds, R-S.D., and Cory Booker, D-N.J., would establish the National Artificial Intelligence Research Resource (NAIRR) that would give AI researchers, educators and students more access to tools, data and other information to help develop new systems. Heinrich, founder and co-chair of the Senate AI Caucus, said in a press release that the NAIRR would go a long way toward “democratizing access to AI,” ensuring that American workers are prepared for the future and primed to lead “rapid advancements” with the emerging technology that boost the U.S. economy. The Daily Scoop Podcast is available every Monday-Friday afternoon. If you want to hear more of the latest from Washington, subscribe to The Daily Scoop Podcast on Apple Podcasts, Soundcloud, Spotify and YouTube.
Inflammation is a double-edged sword. It defends the body against infection and injury, yet when it becomes chronic, it can accelerate aging and fuel the very diseases that shorten human life. For decades, scientists have observed that people with higher levels of inflammatory markers like interleukin-6 (IL6) and C-reactive protein (CRP) tend to have shorter lifespans. But the critical question has always been: does inflammation cause mortality, or does it merely reflect underlying disease? A research paper, titled “Causal effects of inflammation on long-term mortality: A mendelian randomization study” was published in Volume 18 of Aging-US by an international team of researchers, provides a definitive answer by using a powerful genetic technique to untangle cause from effect. The team's investigation demonstrates that the IL6 inflammatory pathway has a direct causal impact on human survival—but with a surprising twist: two components of the same pathway pull in opposite directions. Full blog - https://aging-us.org/2026/04/il6-and-il6r-opposing-forces-of-inflammation-that-shape-human-survival/ DOI - https://doi.org/10.18632/aging.206352 Corresponding author - Eliano P. Navarese - elianonavarese@gmail.com Abstract video - https://www.youtube.com/watch?v=Br1A0jgU-4M Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206352 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, mendelian randomization, inflammatory biomarkers, mortality, cardiovascular disease To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
BUFFALO, NY — February 27, 2026 — A new #research paper was #published in Volume 18 of Aging-US on February 6, 2026, titled “Causal effects of inflammation on long-term mortality: a Mendelian randomization study.” Led by Eliano P. Navarese from Department of Life and Health Sciences, Link Campus University and SIRIO MEDICINE Research Network, Nicolaus Copernicus University, who is also the corresponding author — the study used large-scale Mendelian randomization (MR) to test whether genetically proxied levels of inflammatory biomarkers causally influence long-term all-cause mortality. The analysis combined genome-wide association instruments from more than 750,000 individuals and used FinnGen mortality data (median follow-up 11.7 years) to assess effects on overall survival and major cardiovascular endpoints. Using robust MR methods and multiple sensitivity analyses, the authors report that genetically higher IL6R (soluble IL-6 receptor) levels were associated with reduced all-cause mortality (odds ratio per 1-SD increase: 0.95; 95% CI: 0.91–0.98), and with lower risk of atrial fibrillation, coronary artery disease, stroke, and lung cancer. By contrast, genetically higher IL6 levels were associated with increased mortality (OR 1.05; 95% CI: 1.02–1.08). No significant causal effects were observed for CRP or GDF15, suggesting those markers more likely reflect disease burden than drive it. “These results support IL6R antagonism as a potential strategy for cardiovascular disease prevention.” The authors emphasize that the opposing directions for IL6 and IL6R point to distinct biological mechanisms: IL6 likely promotes chronic pro-inflammatory states that increase cardiovascular risk, while higher circulating IL6R (reflecting altered receptor shedding and signaling) appears to dampen harmful IL6 activity at the vessel wall and myocardium, yielding cardiovascular protection. Sensitivity and cis-MR analyses reinforced the IL6R protective signal and showed minimal evidence of directional pleiotropy. Together, the genetic evidence aligns with clinical trial data for IL6R antagonists in other settings and supports further evaluation of IL6R-targeted strategies for cardiovascular prevention. The paper also notes important limitations and next steps. Analyses were restricted to individuals of European ancestry, so results require replication in other ancestries. Translating genetic evidence into preventive therapies will need careful clinical evaluation, long-term safety assessment, and trials designed for primary prevention in high-risk populations. The authors also call for additional mechanistic work to map how IL6/IL6R modulation alters vascular inflammation and downstream disease processes. DOI - https://doi.org/10.18632/aging.206352 Corresponding author - Eliano P. Navarese - elianonavarese@gmail.com Abstract video - https://www.youtube.com/watch?v=Br1A0jgU-4M Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206352 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, mendelian randomization, inflammatory biomarkers, mortality, cardiovascular disease To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
In this episode, we showcase student research at the 2025 ADSA Annual Meeting in Louisville, Kentucky. Abstracts can be found here: ADSA 2025 Annual MeetingAbstract 2186: Effects of feeding alternative forage silages on early lactation performance and gas production in multiparous Holstein cows. (00:15)Guests: Barbara Dittrich and Dr. Heather White, University of Wisconsin-MadisonCo-Host: Dr. Clay Zimmerman, BalchemBarbara substituted rye silage, triticale silage, rye-camelina-hairy vetch silage, and triticale-camalina-hairy vetch silage to replace 10% of the alfalfa silage in the control diet for her experimental diets. Dry matter intake and gas production were similar across diets. Average milk yield was higher in the rye mix silage group compared to the triticale mix silage group, but no treatment was different than the control. Abstract 1602: Optimizing starch concentrations in low-forage diets. (11:22)Guests: Irie Moussiaux and Dr. Kirby Krogstad, Ohio State UniversityCo-host: Dr. Jeff Elliott, BalchemIrie investigated different levels of starch in a low-forage diet (12.5% NDF) by replacing soybean hulls with corn to yield 20%, 25%, or 30% starch. Dry matter intake and milk production were the same for all three starch concentrations; however, the low starch diet had the highest milk fat yield and energy-corrected milk yield. Abstract 2183: Effects of partial replacement of corn and oat silages with extracted stevia plant on production, behavior, and digestibility in dairy cows. (17:05)Guests: Mariana Marino and Dr. Jose Santos, University of FloridaCo-host: Dr. Clay Zimmerman, BalchemMariana fed stevia plant byproduct as a replacement for corn and oat silage in lactating cow diets. All diets had 40% grain and 60% forage. Stevia byproduct was included at 0, 25%, or 40% of diet dry matter. The byproduct is of very fine particle size and is relatively high in lignin. This resulted in higher dry matter intake, but lower milk production for the highest stevia diet. Abstract 2472: Evaluating feed sorting behavior and TMR composition in roughage intake control feeding systems. (26:38)Guests: Sophia Green and Dr. Heather White, University of Wisconsin-MadisonCo-host: Dr. Ryan Pralle, BalchemSophia evaluated feed sorting in a research intake control feeding system (RIC bins). Feed sorting primarily occurred in the last 12 hours of the feed day, and particle size was smaller at the end of the day than earlier. Compared to fresh feed at hour zero, the chemical composition of the diet did not change throughout the feed day. RIC bins did not introduce additional variance in nutrient consumption. Abstract 1603: Assessing an ex vivo assay with gastrointestinal tissue sections to investigate mucosal immune responses in dairy calves. (35:24)Guests: Paiton McDonald and Dr. Barry Bradford, Michigan State UniversityPaiton challenged explants from the ileum and mid-jejunum in the lab with rotavirus or E. coli compared to a control. Pathogen stimulation increased mRNA abundance of TNF and IL6 above control. Ileal sections secreted more cytokines than jejunal sections. Abstract 1466: The short-term effect of increasing doses of palmitic and stearic acid on plasma fatty acid concentration and mammary arteriovenous difference in Holstein cows. (40:17)Guests: Alanna Staffin and Dr. Kevin Harvatine, Penn State UniversityCo-host: Dr. Jeff Elliott, BalchemAlanna fed mid-lactation cows 0, 150, 300, 500, or 750 grams of palmitic acid, stearic acid, or no supplement control. Palmitic acid increased milk fat yield at lower doses compared to stearic acid. Alanna found that the mammary gland increases its arteriovenous (AV) difference and uptake of palmitic acid when higher concentrations are provided, but AV difference and uptake of stearic acid did not change. Abstract 2006: Does hay improve performance in pair-housed dairy calves? (50:00)Guests: Gillian Plaugher and Dr. Melissa Cantor, Penn State UniversityGillian fed pelleted hay to pair-housed dairy calves along with milk replacer and calf starter. Control calves received milk replacer and calf starter only. Hay-fed pairs grew faster than controls after day 21 and were heavier at day 70. Hay feeding did not impact calf starter DMI or feed efficiency. Abstract 1463: Dietary metabolizable protein and palmitic and oleic acids affect milk production in early lactation dairy cows. (1:02:03)Guests: Jair Parales-Giron and Dr. Adam Lock, Michigan State UniversityCo-host: Dr. Clay ZimmermanJair fed two different levels of metabolizable protein and 3 different levels of supplemental fatty acids from 1 to 22 days in milk followed by a common diet to evaluate carryover effects to day 50. Metabolizable protein and fatty acid supplementation had additive effects on milk production. Cows fed the highest dose of both metabolizable protein and fatty acids produced 8.9 kg more energy-corrected milk per day compared to the low metabolizable protein diet without fatty acid supplementation.
Welcome back to another week & another episode of Rinse & Repeat Radio!For this week's episode - I will be taking over the whole hour with new music from Chris Lake, Disco Lines, Odd Mob, & more.Make sure to subscribe for new music every Wednesday on both Apple Podcasts & Mixcloud.Episode 263- Turn it up!Upcoming dates & more - www.cazesthedj.comInstagram/TikTok/Twitter - @cazesthedj***Tracklisting***1.) Chris Lake & Abel Balder - Ease My Mind (Odd Mob Remix)2.) Chris Lake, Green Velvet - Deceiver (ROSEDRiiVE Remix)3.) OMNOM & Marco Strous - Everyone's Your Friend4.) Low Steppa, Capri (UK) - Got The Funk5.) Disco Lines, Tinashe - No Broke Boys6.) Rihanna x Prospa - BBHMM (Cazes 'Don't Stop' Edit)7.) Sebastian Ingrosso & Steve Angello feat. Namasenda - No Enemies8.) Moby, BLONDISH, Kiko Franco - Natural Blues9.) Disclosure & Sam Smith x Chris Lorenzo x GT_Ofice, Matthew Topper & Robbie Rosen - Latch (Cazes 'Appetite' Edit)10.) Avicii & Nicky Romero x Luke Alexander - I Could Be The One (Cazes 'Hypnotic' Edit)11.) Nicole Moudaber & Castion - Get Back12.) Chris Lake - Savana 13.) CID - Party Jumpin14.) Green Velvet , Chris Lake - Percolator (Mikey Barreneche & Giometrik Edit)15.) Jack Orley - Swing Yo Hip (feat Siena Liggins) 16.) Zillamatic, Cazes - NaughtyUpcoming Dates6/13 - Good Night John Boy - Chicago, IL6/14 - Good Night John Boy - Cleveland, OH6/15 - Azure Day Party @ Ciel - Washington, DC6/28 - M. Bird - Tampa, FL
Welcome back to Rinse And Repeat Radio! On this week's guest mix we have Icon out of Houston, TX.You can catch Icon rockin every weekend as some of the coolest spots in the city as well as all around the country.He took over the first half of the episode with a guest mix including a bunch of his favorite records, remixes, edits, & more.Episode 262 turn it up! **Tracklisting**** Icon Guest Mix **1.) Lupe Fiasco Ft. Mathew Santos Vs. M83 Vs. Morten - Superstar (Icon 'Midnight City' X ‘Timeless' Edit)2.) Hugel, J Balvin & Ellie Goulding Ft Topic, Arash & Daecolm - I Adore You (Purari Remix) 3.) Soulja Boy Vs. Biscits - Turn My Swag On (Rick Wonder 'Freak' Edit)4.) Bart Skils & Layton Giordani - Deadly Valentine 5.) Tame Impala - Let It Happen (Ship Wrek Remix)6.) Chris Lake & Abel Balder - Ease My Mind (Odd Mob Extended Remix)7.) Lola Young & Christian Nielsen - Messy Firefly (Corey Craig Edit) 8.) Rels B - Un Rodeoooo (Icon Remix) 9.) Celeda, Jesus Fernandez, Karl8 & Andrea Monta - The Underground 10.) The Prodigy - Funky Shit (James Hype Edit) 11.) Mau P - People Talk People Sing 12.) Parisi & Daniel Allan - Man Down13.) Cid - Pass Out** Cazes Mix**14.) Alok, Laszewo, A$ap Rocky - Highjack (Right Back)15.) Cid - Party Jumpin'16.) Tony Dark Eyes - Drippin17.) Cat Dealers, Makj, Faiolli - I'm A Man18.) Omnom & Marco Strous - Everyone's Your Friend 19.) Acraze - Telephone Ringin'Upcoming dates & more - www.cazesthedj.comInstagram/TikTok/Twitter - @cazesthedjUpcoming Dates6/6 - Ayu Dayclub - Las Vegas, NV6/7 - Komodo Lounge - Dallas, TX6/13 - GoodNight John Boy - Chicago, IL6/14 - GoodNight John Boy - Cleveland, OH6/15 - Azure Day Party - Washington, DC
Welcome back to Rinse And Repeat Radio! On this week's guest mix we have return guests the Deux Twins out of Los Angeles, CAYou can catch the Deux Twins rockin' at some of the coolest spots all around the country like XS (Las Vegas), Zouk (LA), and so much more.They took over the first half of the episode and put together a mix just for us including a bunch of their originals, remixes, edits, & more.Episode 261 turn it up! **Tracklisting**** Deux Twins Guest Mix **1.) Tommy Richman - Actin Up (Deux Twins Remix)2.) Chris Lake - Toxic3.) Deux Twins - Id4..) Faed - Talkin Sh*t5.) Sidepiece - Lick 6.) Charli Xcx - Guess (Deux Twins Remix)7.) Travis Scott - Antidote (Deux Twins Remix)8. Playboi Carti - Evil Jordan (Hills Remix)9. Glo Rilla - Tgif (Deux Twins Remix)10.) Zillamatic & Cazes - Naughty11. 2 Chainz - Watch Out (Deux Twins Remix) 12.) Chris Lake - I Want You13. Tommy Richman - Million Dollar Baby (Deux Twins Remix)14. Chrystal - The Days (Relo ‘Midnight City' Remix)** Cazes Mix **15.) Prospa - Don't Stop16.) Tony Romera - Time To Move17.) Esse - Detroit18.) Cajmere Ft. Dajae - Brighter Days (Alok, Santti & Ruddek Remix)19.) Discip - Mind Games20.) Sidepiece - Lick21.) Luis Torres - Love At The RaveUpcoming dates & more - www.cazesthedj.comInstagram/TikTok/Twitter - @cazesthedjUpcoming Dates6/6 - Ayu Dayclub - Las Vegas, NV6/7 - Komodo Lounge - Dallas, TX6/13 - GoodNight John Boy - Chicago, IL6/14 - GoodNight John Boy - Cleveland, OH6/15 - Azure Day Party - Washington, DC
Welcome back to another week & another episode of Rinse & Repeat Radio!For this week's episode - I will be taking over the whole hour with new music from Prospa, FAED, Acraze & more.Make sure to subscribe for new music every Wednesday on both Apple Podcasts & Mixcloud.Episode 260- Turn it up!Upcoming dates & more - www.cazesthedj.comInstagram/TikTok/Twitter - @cazesthedj***Tracklisting***1.) CASSIMM - I Like It2.) DJ S.K.T - Deeper3.) Acraze - Telephone Ringin4.) InntRaw - Bye Bye Bye5.) Tony Romera - Time To Move6.) Prospa - Don't Stop7.) Sebastian Ingrosso & Steve Angello feat. Namasenda - No Enemies8.) FAED - TALKIN SH*T9.) Lady Gaga - Abracadabra (MAKJ Remix)10.) Chris Lake & Ragie Ban - Toxic11.) Discip - Serotonine12.) Crespo - Lose Control13.) Cassian, SCRIPT, Belladonna (ofc) - Where I'm From14.) Swedish House Mafia x KREAM - Save The World (Cazes 2025 Edit)15.) Pendulum - The Island Pt.1 (SQU4RE Bootleg)Upcoming Dates6/6 - Ayu Dayclub - Las Vegas, NV6/7 - Komodo Lounge - Dallas, TX6/13 - GoodNight John Boy - Chicago, IL6/14 - GoodNight John Boy - Cleveland, OH6/15 - Azure Day Party - Washington, DC
Cancer cachexia isn't just weight loss—it's a hijacking of motivation
W tym odcinku zagłębiamy się w świat kanabichromenu (CBC) – jednego z mniej znanych, ale niezwykle obiecujących fitokanabinoidów. Naszym gościem jest Izabela Piątek, współwłaścicielka Polskiej Grupy Kapitałowej 3H, ekspertka od badań i rozwoju w branży konopnej. Dowiesz się, dlaczego CBC nazywany jest „czarnym koniem” w leczeniu depresji, jak działa na układ nerwowy, skórę oraz stany zapalne.Porozmawiamy także o jego potencjale w terapii bólu migrenowego, nowotworów i problemów jelitowych. Ale to nie wszystko – Izabela Piątek zdradza kulisy produkcji kosmetyków konopnych, radzi, jak rozpoznać wysokiej jakości ekstrakty i unikać oszustów na rynku.Jeśli interesuje Cię, jak nauka odkrywa tajemnice konopi oraz jakie są perspektywy rozwoju tej branży, ten odcinek jest dla Ciebie. Przygotuj się na sporą dawkę wiedzy, ciekawostek i praktycznych wskazówek. Włącz i posłuchaj już teraz!
With wineries, outdoor adventures, historical markers, and friendly small towns, Southern Illinois is truly a hidden gem that is totally worth checking out. Today, Stevie is joined by Jessica Baine from the Caffeine Until Cocktails blog, who talks about the Shawnee National Forrest, things to do in the Fall, and much more when it comes to visiting Souther Illinois. Show Notes ⬇️ Published on 9/20/24 Timecodes0:00 - Intro2:07 - What About Southern Illinois Makes it a Unique Place to Visit and Explore?2:48 - More About the Shawnee National Forrest3:54 - Garden of the Gods and What its Like to Explore it5:27 - Historical Markers in Jackson County, IL6:41 - Wineries in Jackson County, IL7:39 - Top Things to do in the Fall in Southern Illinois10:22 - Ava, IL12:04 - Effingham, IL14:04 - Southern Illinois Towns are Hidden Gems15:25 - Murphysboro, IL17:49 - Stay Connected with Caffeine until Cocktails20:18 - Jessica Baine is a Student of Travel Check Out These Southern Illinois Blogs from Caffeine Until Cocktails101 Things to do in Southern IllinoisHistorical Markers in Jackson County, IllinoisJackson County Wineries: Southern Illinois TourismTop 9 Fall Activities: A Guide to Fall in Southern IllinoisWelcome to Ava, IllinoisSummer in Effingham, IllinoisHow to Spend One Day in Murphysboro, ILFollow Caffeine Until Cocktails on Instagram or PinterestExplore Group Experience to Learn how to Build your Travel Tribe
90 Day Gays: A 90 Day Fiancé Podcast with Matt Marr & Jake Anthony
Thank you Space City! Houston, We Love You!Alex meets Adriano's mother and makes a plea for her religion. Madelein breaks down when Luke hesitates while visiting a wedding venue. Kyle gets an STD test as Ani looks to a friend for advice. Shawn plans a big surprise for Alliya.---6/2 Phoenix,AZ6/5 Columbus, OH6/6 Indianapolis,IN6/7 Chicago, IL6/12 Atlanta,GA 6/13 Charlotte, NC Hosted on Acast. See acast.com/privacy for more information.
90 Day Gays: A 90 Day Fiancé Podcast with Matt Marr & Jake Anthony
Not even the thunderstorm in Dallas can stop the boys! Thank you Dallas and Ft Worth, Sissies! Episode Title: S8 Ep11: "Weeping Beauty"Angela learns the fate of Michael's visa. Patrick presents Thais with the worst birthday gift. Gino's actions push Jasmine over the edge. Ashley decides to protect her finances. Liz and Ed try to move on. Emily wants to meet Kobe's ex. Loren has an emotional homecoming.See Y'all on the road!5/31 Houston,TX6/2 Phoenix,AZ6/5 Columbus, OH6/6 Indianapolis,IN6/7 Chicago, IL6/12 Atlanta,GA 6/13 Charlotte, NC Hosted on Acast. See acast.com/privacy for more information.
Ever wondered why some people seem to avoid sickness effortlessly, while others catch every bug in the vicinity? It turns out, luck and genetics may both play a role. In this episode, we uncover the secrets of the IL6 gene, responsible for coding interleukin 6 (IL-6), a crucial immune messenger. Discover how certain variants of the IL6 gene, such as rs1800795, are linked to higher or lower IL-6 levels, affecting immunity and susceptibility to infections. But the story doesn't end there – we explore other variants like rs1800796, connecting genetic makeup to conditions like acne, longevity, muscle recovery, and inflammatory diseases. Is your IL6 gene making you ill, or is it your genetic strength?
Is gay retirement different? Do LGBTQ+ folks need their own retirement communities? Do some already exist and if so where?Did you know that queer people are going back into the closet as we age? That's according to an August 2023 Salon article. That's in part because of the 508 anti-LGBTQ+ laws at the state-level throughout the country, per the ACLU.That makes retirement and retirement housing more unaffordable for us - increasing the pink tax.That's why you're listening to Queer Money episode #470 because we're kicking off our new Gay Retirement 101 series.Today, we're sharing our favorite LGBTQ+ retirement communities10 of our favorite places for LGBTQ+ individuals tolive in retirement1. Pueblo Manor in Apache Junction, AZ2. Triangle Square in Hollywood, CA3. A Place for Us in Cleveland, OH4. Rainbow Vista in Gresham, OR5. Town HallApartments in Chicago, IL6. Fountaingrove Lodge in Santa Rosa, CA7. Wilton Manors, FL8. The Residences atSeashore Point in Provincetown, MA9. Village Hearth Cohousing in Durham, NC 10. Birds of a Feather in Village of Pecos, NMFor the resources and to connect with our guests, get the show notes at: https://queermoneypodcast.com/subscribe Follow us:Queer Money Instagram Queer Money YouTubeQueer Money on TiktokDownload your FREE Queer Money Kickstarter a 9-step Guide to Kickstart Your Journey to Financial Independence
Take 10 with Tim – September 15, 2023 @ 8 am1.Word association on each of these recently called up kida.Ronny Mauriciob.Maysn Winnc.Jordan Wicksd.Jasson Domingueze.Connor Phillipsf.Evan Carterg.Pete Crow-Armstrong2.What one or two surprise players have been making a difference for you down the stretch?3.Let's look at the MLB races4.Heston Kerjstad gets the call after Ryan Mountcastle goes out with a shoulder injury. Any interest?5.Have we seen the last at-bat for Shohei Ohtani for the season? He hasn't played since September 3rd. He's out with an oblique, but of course the Angels didn't put him on the IL6.I just finished writing the Pittsburgh Pirates minor league system. While I like the system very much, I've liked it for the past few years. But their players have just not performed. Hayes, Contreras, End Rodriguez, Mitch Keller, and Henry Davis.a.They look great in the minor leagues and then underperform once they get promoted to the Majors.7.Give me on hitter that you will target for this weekend's FAAB?8.Give me one pitcher that you will target for this weekend's FAAB?This show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/3306394/advertisement
A new research paper was published in Aging (Aging-US) Volume 15, Issue 14, entitled, “Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span.” The decrease in the podocyte's lifespan and health-span that typify healthy kidney aging cause a decrease in their normal structure, physiology and function. The ability to halt and even reverse these changes becomes clinically relevant when disease is superimposed on an aged kidney. NLRP3 [nod-like receptor protein 3] expression is increased in podocytes of mice with advanced age and contributes to their damage. “However, the functional consequence of increased levels of NLRP3 in aged podocytes is unknown.” In this new study, researchers Natalya Kaverina, R. Allen Schweickart, Gek Cher Chan, Joseph C. Maggiore, Diana G. Eng, Yuting Zeng, Sierra R. McKinzie, Hannah S. Perry, Adilijiang Ali, Christopher O'Connor, Beatriz Maria Veloso Pereira, Ashleigh B. Theberge, Joshua C. Vaughan, Carol J. Loretz, Anthony Chang, Neil A. Hukriede, Markus Bitzer, Jeffrey W. Pippin, Oliver Wessely, and Stuart J. Shankland from the University of Washington, Cleveland Clinic Foundation, National University Hospital Singapore, University of Pittsburgh, University of Michigan, and the University of Chicago hypothesized that reducing NLRP3 signaling earlier at middle-age improves overall podocyte health and slows down healthy podocyte aging in mice. “To this end, we performed a comprehensive analysis of inflammasome signaling including pharmacological and genetic NLRP3 loss-of-function approaches.” RNA-sequencing of podocytes from middle-aged mice showed an inflammatory phenotype with increases in the NLRP3 inflammasome, signaling for IL2/Stat5, IL6 and TNF, interferon gamma response, allograft rejection and complement, consistent with inflammaging. Furthermore, injury-induced NLRP3 signaling in podocytes was further augmented in aged mice compared to young ones. The NLRP3 inflammasome (NLRP3, Caspase-1, IL1β IL-18) was also increased in podocytes of middle-aged humans. Higher transcript expression for NLRP3 in human glomeruli was accompanied by reduced podocyte density and increased global glomerulosclerosis and glomerular volume. Pharmacological inhibition of NLRP3 with MCC950, or gene deletion, reduced podocyte senescence and the genes typifying aging in middle-aged mice, which was accompanied by an improved podocyte lifespan and health-span. Moreover, modeling the injury-dependent increase in NLRP3 signaling in human kidney organoids confirmed the anti-senescence effect of MC9950. Finally, NLRP3 also impacted liver aging. “In summary, our results demonstrate for the first time that aging podocytes acquire an inflammatory phenotype, which include the NLRP3 inflammasome and which is consistent with inflammaging.” DOI - https://doi.org/10.18632/aging.204897 Corresponding authors - Oliver Wessely - wesselo@ccf.org, and Stuart J. Shankland - stuartjs@uw.edu Keywords - aging, kidney, podocyte, NLRP3 inflammasome, reporter About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ For media inquiries, please contact: MEDIA@IMPACTJOURNALS.COM
DrBeen#26 Near Infrared Light Therapy Reduces Inflammation Ep 26: Near Infrared Light Therapy Reduces Inflammation Near infrared light therapy reduces inflammatory mediators by 50% and IL6 by 80%. Let's review. DrBeen: Medical Education Onlinehttps://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/ URL list from Thursday, Sep. 15 2022 Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19 - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451450/ Not scientific but interesting article about heat-shock proteins and infrared.Infrared Sauna Use And Heat Shock Proteinshttps://saunas.org/infrared-sauna-use-and-heat-shock-proteins/ Some more referencesNear-infrared spectroscopy - Wikipediahttps://en.wikipedia.org/wiki/Near-infrared_spectroscopy Near Infrared (NIR) Light Therapy of Eye Diseases: A Review - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738953/#:~:text=NIR%20and%20LEDs%20light%20can,modify%20biological%20functions%20of%20cells. Sep 15, 2022 at 10:13 PMRed Light Therapy vs. Infrared Saunahttps://youtu.be/vwgLlYcYZ_4 Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders - PubMedhttps://pubmed.ncbi.nlm.nih.gov/23492552/ The Benefits of Near-Infrared Light Therapyhttps://platinumtherapylights.com/blogs/news/near-infrared-light-therapy Near-Infrared Light and Skin: Why Intensity Matters - Abstract - Challenges in Sun Protection - Karger Publishershttps://www.karger.com/Article/Abstract/517645 The effect of red-to-near-infrared (R/NIR) irradiation on inflammatory processes - PubMedhttps://pubmed.ncbi.nlm.nih.gov/31170016/#:~:text=Introduction%3A%20Near%2Dinfrared%20(NIR,blood%20flow%20and%20tissue%20oxygenation. Near-infrared light reduces glia activation and modulates neuroinflammation in the brains of diet-induced obese mice | Scientific Reportshttps://www.nature.com/articles/s41598-022-14812-8 Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer's disease | Alzheimer's Research & Therapy | Full Texthttps://alzres.biomedcentral.com/articles/10.1186/s13195-022-01022-7 Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19 - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451450/ What Is Near-Infrared Light? - StoneLockhttps://stonelock.com/what-is-near-infrared-light/#:~:text=Infrared%20Light%20(IR)%20is%20the,past%20what%20we%20can%20see. Toll-like receptor 4 - Wikipediahttps://en.wikipedia.org/wiki/Toll-like_receptor_4 NF-κB - Wikipediahttps://en.wikipedia.org/wiki/NF-%CE%BAB Lipopolysaccharidehttps://en.wikipedia.org/wiki/Lipopolysaccharide Disclaimer:This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. covid 19dr beenflcccinflammationinfrared light therapy
Eno and DVR discuss some of the biggest risers -- and a few fallers -- among starting pitchers from the first month of the season. Rundown0:45 Jacob deGrom Returns to the IL6:23 Nathan Eovaldi's First Month in Texas13:51 Dustin May's Rise Up Eno's Rankings18:50 Freddy Peralta's Velo Returns; Pitch Mix is Strong23:08 Jesús Luzardo's Step Forward in Miami26:26 Joe Ryan New Arsenal28:54 Zac Gallen's Continued Dominance31:20 Other Big Movers44:10 JP Sears: Sneaky Fallback Add From April?50:30 Hunter Brown's First 50 MLB Innings57:04 Big Fallers in the RankingsFollow Eno on Twitter: @enosarrisFollow DVR on Twitter: @DerekVanRipere-mail: ratesandbarrels@theathletic.comSubscribe to The Athletic at $1/month for the first year: theathletic.com/ratesandbarrelsSubscribe to the Rates & Barrels YouTube channel: https://www.youtube.com/c/RatesBarrelsThis episode is brought to you by BetterHelp. Give online therapy a try at betterhelp.com/rates and get on your way to being your best self.Head to factor75.com/rates40 and use code RATES40 to get 40% off your first box. Hosted on Acast. See acast.com/privacy for more information.
Video: Scientist Carl Sagan testifying to the U.S. Senate in 1985 on the greenhouse effect: (2:00) WEF: The Most Evil Business in the World – Samuel Leeds (10:49) Israel caught hiding BOMBSHELL Pfizer Frequent nut consumption associated with less inflammation Brigham and Women's Hospital, September 1, 2022 In a study of more than 5,000 people, investigators from Brigham and Women's Hospital have found that greater intake of nuts was associated with lower levels of biomarkers of inflammation, a finding that may help explain the healthbenefits of nuts. The results of the study appear in the American Journal of Clinical Nutrition. “Population studies have consistently supported a protective role of nuts against cardiometabolic disorders such as cardiovascular disease and type 2 diabetes, and we know that inflammation is a key process in the development of these diseases,” said corresponding author Ying Bao, MD, ScD, an epidemiologist in BWH's Channing Division of Network Medicine. “Our new work suggests that nuts may exert their beneficial effects in part by reducing systemic inflammation.” Previously Bao and her colleagues observed an association between increased nut consumption and reduced risk of major chronic diseases and even death, but few prospective cohort studies had examined the link between nut intake and inflammation. In the current study, the research team performed a cross-sectional analysis of data from the Nurses' Health Study, which includes more than 120,000 female registered nurses, and from the Health Professionals Follow-Up Study, which includes more than 50,000 male health professionals. The team assessed diet using questionnaires and looked at the levels of certain telltale proteins known as biomarkers in blood samples collected from the study participants. They measured three well-established biomarkers of inflammation: C-reactive protein (CRP), interleukin 6 (IL6) and tumor necrosis factor receptor 2 (TNFR2). After adjusting for age, medical history, lifestyle and other variables, they found that participants who had consumed five or more servings of nuts per week had lower levels of CRP and IL6 than those who never or almost never ate nuts. In addition, people who substituted three servings per week of nuts in place of red meat, processed meat, eggs or refined grains had significantly lower levels of CRP and IL6. Peanuts and tree nuts contain a number of healthful components including magnesium, fiber, L-arginine, antioxidants and unsaturated fatty acids such as α-linolenic acid. Researchers have not yet determined which of these components, or if the combination of all of them, may offer protection against inflammation, but Bao and her colleagues are interested in exploring this further through clinical trials that would regulate and monitor diet. “Much remains unknown about how our diet influences inflammation and, in turn, our risk of disease,” said Bao. “But our study supports an overall healthful role for nuts in the diet and suggests reducing inflammation as a potential mechanism that may help explain the benefits of nuts on cardiometabolic diseases.” Blueberry extract could help fight gum disease and reduce antibiotic use Laval University (Quebec), September 2, 2022 Gum disease is a common condition among adults that occurs when bacteria form biofilms or plaques on teeth, and consequently the gums become inflamed. Some severe cases, called periodontitis, call for antibiotics. But now scientists have discovered that wild blueberry extract could help prevent dental plaque formation. Their report in ACS' Journal of Agricultural and Food Chemistry could lead to a new therapy for periodontitis and a reduced need for antibiotics. Many people have had some degree of gum inflammation, or gingivitis, caused by dental plaque. The gums get red and swollen, and they bleed easily. If left unchecked, the condition can progress to periodontitis. The plaque hardens into tartar, and the infection can spread below the gum line and destroy the tissue supporting the teeth. To treat this condition, dentists scrape off the tartar and sometimes have to resort to conventional antibiotics. But recently, researchers have started looking at natural antibacterial compounds to treat gum disease. Daniel Grenier and colleagues wanted to see if blueberry polyphenols, which work against foodborne pathogens, could also help fight Fusobacterium nucleatum, one of the main species of bacteria associated with periodontitis. In the lab, the researchers tested extracts from the wild lowbush blueberry, Vaccinium angustifolium Ait., against F. nucleatum. The polyphenol-rich extracts successfully inhibited the growth of F. nucleatum, as well as its ability to form biofilms. It also blocked a molecular pathway involved in inflammation, a key part of gum disease. The researchers say they're developing an oral device that could slowly release the extract after deep cleaning to help treat periodontitis. Meat consumption contributing to global obesity University of Adelaide, August 11, 2022 Should we be warning consumers about over-consumption of meat as well as sugar? That's the question being raised by a team of researchers from the University of Adelaide, who say meat in the modern diet offers surplus energy, and is contributing to the prevalence of global obesity. “Our findings are likely to be controversial because they suggest that meat contributes to obesity prevalence worldwide at the same extent as sugar,” says Professor Maciej Henneberg. “In the analysis of obesity prevalence across 170 countries, we have found that sugar availability in a nation explains 50% of obesity variation while meat availability another 50%. After correcting for differences in nations' wealth (Gross Domestic Product), calorie consumption, levels of urbanization and of physical inactivity, which are all major contributors to obesity, sugar availability remained an important factor, contributing independently 13%, while meat contributed another 13% to obesity. “While we believe it's important that the public should be alert to the over-consumption of sugar and some fats in their diets, based on our findings we believe meat protein in the human diet is also making a significant contribution to obesity,” Professor Henneberg says. “There is a dogma that fats and carbohydrates, especially fats, are the major factors contributing to obesity,” Mr You says. “Whether we like it or not, fats and carbohydrates in modern diets are supplying enough energy to meet our daily needs. Because meat protein is digested later than fats and carbohydrates, this makes the energy we receive from protein a surplus, which is then converted and stored as fat in the human body.” “Nevertheless, it is important that we show the contribution meat protein is making to obesity so that we can better understand what is happening. In the modern world in which we live, in order to curb obesity it may make sense for dietary guidelines to advise eating less meat, as well as eating less sugar,” he says. Study suggests possible link between artificial sweeteners and heart disease French National Institute for Health and Medical Research, September 7, 2022 A large study of French adults published by The BMJ today suggests a potential direct association between higher artificial sweetener consumption and increased cardiovascular disease risk, including heart attack and stroke. The findings indicate that these food additives, consumed daily by millions of people and present in thousands of foods and drinks, should not be considered a healthy and safe alternative to sugar, in line with the current position of several health agencies. Artificial sweeteners are widely used as no- or low-calorie alternatives to sugar. They represent a $7.2 billion (£5900m; €7000m) global market and are found in thousands of products worldwide, particularly ultra-processed foods such as artificially sweetened drinks, some snacks, and low calorie ready meals. Several studies have linked consumption of artificial sweeteners or artificially sweetened beverages (ASB) to weight gain, high blood pressure, and inflammation. To investigate this further, a team of researchers at the French National Institute for Health and Medical Research (Inserm) and colleagues drew on data for 103,388 participants (average age 42 years; 80% female) of the web-based NutriNet-Santé study, launched in France in 2009 to investigate relations between nutrition and health. Dietary intakes and consumption of artificial sweeteners were assessed by repeated 24-hour dietary records and a range of potentially influential health, lifestyle, and sociodemographic factors were taken into account. A total of 37% of participants consumed artificial sweeteners, with an average intake of 42.46 mg/day, which corresponds to approximately one individual packet of table top sweetener or 100 mL of diet soda. The researchers found that total artificial sweetener intake was associated with an increased risk of cardiovascular disease (absolute rate 346 per 100,000 person years in higher consumers and 314 per 100,000 person years in non-consumers). Artificial sweeteners were more particularly associated with cerebrovascular disease risk (absolute rates 195 and 150 per 100,000 person-years in higher and non-consumers, respectively). Aspartame intake was associated with increased risk of cerebrovascular events (186 and 151 per 100,000 person-years in higher and non-consumers, respectively), while acesulfame potassium and sucralose were associated with increased coronary heart disease risk (acesulfame potassium: 167 and 164 per 100,000 person-years; sucralose: 271 and 161 per 100,000 person-years in higher and non-consumers, respectively). Your soap and toothpaste could be messing with your microbiome University of Chicago, September 2, 2022 Antimicrobial chemicals found in common household products could be wreaking havoc with people's guts, according to a research paper out this week in the journal Science. Triclosan is an antibacterial compound used in soaps, detergent and toothpaste, as well as toys and plastics. It was originally only used in hospitals, but it found its way into homes as Americans became more germ-phobic. (However, recent studies have found it no more effective at killing bacteria than plain soap. ) Now, there are growing concerns about the possible negative effects of the chemical on human health and the environment. According to the US Food and Drug Administration (FDA), animal studies have shown that the chemical can act as a hormone disruptor. A 2008 study found traces of triclosan in the urine of 75% of the participants – some as young as six. The chemical has also been found in more than half of freshwater streams in the US. Disturbing the human microbiome has been “linked to a wide array of diseases and metabolic disorders, including obesity, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and behavioral and metabolic disorders,” wrote the paper's authors, Alyson L Yee and Jack A Gilbert. Yee and Gilbert also suggested that exposure to triclosan could be even more detrimental to the health of developing fetuses and newborns than to adults. A 2014 New York University study found that gut disruptions in early infancy could have lasting negative effects on immune and brain development. Triclosan could also be contributing to antibiotic resistance, which scientists believe is caused by the overuse of antimicrobials in humans and animals. There are partial bans of the chemical in the European Union and in Minnesota, and the FDA says it will continue reviewing the chemical for its safety. Exposure to phthalates could be linked to pregnancy loss Peking University, September 2, 2022 A new study of more than 300 women suggests that exposure to certain phthalates — substances commonly used in food packaging, personal-care and other everyday products — could be associated with miscarriage, mostly between 5 and 13 weeks of pregnancy. The research, appearing in the ACS journal Environmental Science & Technology, is the first epidemiological study on non-work-related exposure to phthalates to provide evidence for the possible link among a general population. Out of concern over the potential health effects of phthalates, the U.S. has banned six of these substances from use in certain products made for young children. But many are still included as ingredients in paints, medical tubes, vinyl flooring, soaps, shampoos and other items. Research on phthalates has shown that long-term exposure to low levels of some of these compounds harms lab animals' health and can increase their risk for pregnancy loss. Additionally, at least one study found that female factory workers exposed to high levels of phthalates through their work were at a higher risk for miscarriage. But there is little epidemiological evidence of phthalates' effects on pregnancy among women with non-occupational exposure. Jianying Hu, Huan Shen and colleagues wanted to find out if there might be a link. The researchers tested urine samples from 132 women who had miscarriages and 172 healthy pregnant women in China. They found pregnancy loss was associated with higher levels of urinary phthalate metabolites from diethyl phthalate (DEP), di-isobutyl phthalate (DiBP) and di-n-butyl phthalate (DnBP). Although this doesn't prove that phthalates cause pregnancy loss, the study suggests an association exists that the researchers say should be studied further.
Gut Immune Body Brain Axis.Dr Gundry:Leaky Gut, gut microbiome and dietRenowned Cardiovascular Surgeon who realised that all he was doing was treating thesymptoms so he studied the underlying causes.The lining of the gut is one cell thickAs bacteria break down the gut that is when ageing startsIbuprofen or roundup disastrous the bacteria populationSkin is a mirror of the lining of the gutJoints do not naturally wear out.Animal model C Elegans as bacteria begin to break down the wall of the gut that is whenageing starts105 year old people have a diverse set of bugs identical to a healthy 30 year old. It is notattacking the wall of the gut.Ecermansia musinophilia. Lives in the mucous layer whose job is to trap lectins plantproteins looking for sugar molecules and to protect the wall of the gut from harmful bacteria.Ecermansia musinophilia eats mucus which in turn makes more mucus.Metformin works by increasing mucous and this change in bacteria makes some peoplehave mild diarrhoea as the bacteria change.If we damage this lining eg ibuprofen or food with roundup destroys the bacteria populationand gut lining.Glyocosade an antibacterial damages Ecermansia Musinophilia even though it does notdirectly affect human cells.Antibiotics in food or direct prescription eg ladies who take low dose for UTI have a higherincidence of heart disease.Heart disease is an autoimmune disease starting in the gut.Cholesterol is an innocent bystander which gets sucked into the inflamed wall of a bloodvessel.Infants with heart transplants have coronary artery disease with pathology identical withtypical coronary artery disease.Lectins which are a foreign protein which can stick to sugar molecules on the surface ofblood vessels are the cause of atherosclerosis and removing lectins reduces those markers.Lectins are one of the plant defence systems. Sticky proteins that look for specific sugarmolecules to stick to which insights an inflammtory response.Joints do not normally wear out. Usually you can find bacterial particles in the joint fluid ofarthritisBecauseLectins broke down the wall of the gut. 65% of the immune system is behind the wall of thegut because the gut is where the outside word gets through. A reason why we store fat inthe gut is to provide energy to the immune system. Similarly fat on the outside ofatherosclerotcic blood vessles correlates with the severity of inflammation.Fat is not the cause . It is there because of the inflammation and the inflammation is theredue to the leaky gut.The immune system responds to antigens on bacteria of viruses. Lectins have antigens withcross reactivity with other proteins in the body. Eg thyroid.Nightshade vegetables or peanutsLectins disrupt the microbiome and break up the lining of the gut allowing entry by lectinsand by bacteria or bacterial particles.Hence if you inject a bacterial lipopolysaccharide into a person you can induce septic shock.Alzheimers Parkinsons is neuroinflammation.Most amyloid is produced by bacteria in the gut. Therefore 40 billion dollars invested inantiamyloid drugs has been a waste because amyloid is produced by the amyloid producingbacteria inthe gut fet by western diet. Then the amyloid has to get through the wall of the gut.Once they get through the gut wall and goto the brain it will produce more amyloid.Cholesterol and amyloid coexist in dementia in those with the apoE gene.The apo E gene codes for a carrier molecule because it is less efficient at transportingcholesterol. It cannot get out of the cell after it has been attracted by inflammation.Faecal microbial transplant:1970s broad spectrum antibiotics came out which made it much quicker to treat infectionsbut it also wiped out the gut bacteria. Normally 10000 species of bacteria.Pseudomembranous colitis was caused by Clostridium Difficile over growing. Initial studydone from the faeces of medical students.Faecal enemas treated the pseudomembranous colitis.Meat with animals treated by antibiotics can also cause problems.60% of faeces is bacteriaOral microbiome and cloud of bacteria around us –Holobiome . This defines our personalspace.Kissing is a human and ape characteristic. Exchanging oral microbiome. Bacteria decidewhether the other person's bacteria are compatible with them.Women have a gut feeling because they are more capable of listening to their microbiome. We inherit our microbiome from our mother. All of the mitochondria are involved with bacteriainherited from our mother. Bacteria communicate to their ‘sisters 'ie the body's mitochondria.Autism: kids have a different microbiome than ‘normal'The placental microbiome is important in educating the foetal immune system.Oral faecal transplants for 6 weeks in autistic kids. Almost immediately 50% autismsymptoms reduced.Ecermansia like tubers, mushrooms, -study in Asia find 90% reduction in Alzheimers withtwo cups of mushrooms a week.Inulin containing compounds eg chicory, radicchio, jerusalem artichoke.Exercise women who exercise routinely from midlife have a 90% reduction in Alzheimers. Inthose who get AD it happens 11 years later. Housework can be important part of exercise.Meditation and yoga also changes the gut microbiome.Lymph system in the brain in deep sleep -early in the sleep cycle-shrinks by 20% and thesebad proteins are squeezed out. You need a 3-4 hour window between sleep and dinnerbecause blood flow diverts to the gut.Olive oil /walnuts / mediterranean low fat diet: first two groups improved memory after 5years. 3rd group lost memoryThose with CVD had a 30% reduction in events, the low fat group continued CVS events.Polyphenos in olive oil grow proteinsTMAO is made by gut bacteria primarily from animal protein especially choline eg egg yolkand carnitine . TMAO damages blood vessels. Polyphenols in certain olive oil and red winebalsamic vinegar that paralyse enzyme systems in the bacteria so they do not make TMAO.However the logical error here is that eggs which are high in choline are not associated withincreased morbidity.Vitamin D at least 5000 units a day . Almost all cancer patietns and autoimmune pateitnshave low vitamin D. HIgher your VItamin D the longer your telomere. Stem cells in the gutare simulated by vitamin D.VItamin CLectins are present in most plant foods but especially high in:legumes, such as beans, lentils, peas, soybeans, and peanutsnightshade vegetables, such as tomatoes and eggplantdairy products, including milkgrains, such as barley, quinoa, and riceThe Roll of Inflammation in Depression and FatigueFrontiers In Immunology:CH Lee 2019:Immune system link to depression first noticed with immunotherapy eg INFa (which activates an inflammatory antiviral response) for Hepatitis C : associated with raised proinflammatory cytokines and depression and fatigue.20% of patients treated with INFa developed depression which resolved on discontinuationbut also increased the risk of depression in future.Also people with higher IL6 aged 9 were more likely to have depression aged 18 in a dosedependent manner.Innate immune system seems to be lower in depression eg NK cells and also less antiinflammatory regulatory T cells whereas inflammatory monocytes are activated.There is commonality in immune activation from autoimmune disorder such as multiplesclerosis or immune reactions in sepsis.Antidepressants reduce inflammation while a higher baseline level of inflammation predicts apoorer treatment response.People with depression have been shown to have higher inflammatory markers which canbe used to predict treatment efficacy and future recurrences of depression.Elevated inflammatory markets eg TNFa after an MI disrupt the blood brain barrier causingdepression.Inflammatory changes in the brain with raised TNFa in the hippocampus and striatumprecede development of depressive symptoms.Neurogenesis is inhibited by the kynurenine pathway which is rescued by both inhibitors ofthis pathway and traditional antidepressants.TNFa also increases glutamate release causing exocytotic damage to surroundingsneurones.Conditions associated with chronic immune activation such as asthma, atopy, diabetes mMS, RhA, SLE are all associated with raised levels of depression eg 36% of asthma havedepression who also had higher TNFa than those who were not depressed. 75% in RhAMS up to 50% risk of depression.Acute inflammation with sepsis also causes depression and raises the risk of depression infuture which in animal models can be reduced by using steroid during the acute sepsis.Antidepressants reduce inflammatory markers perhaps SNRI more effective than SSRI andalso ECT adds in return to normal of NK activity.Directly reducing the immune response eg anti TNF a or Caspase Inhibitors have beenshown to reduce depression. Rituximab which is an antibody that targets and depletes Bcells in the treatment of RhA also reduces depression.Aspirin can reduce depression but can also reduce the effect of an SSRI.
VIDEOS: 1. The Anti-Smartphone Revolution – (13:23) ColdFusion 2. Gravitas Plus: Explained: The China-Taiwan conflict (9:11) HEALTH NEWS Astonishing effects of grapes, remarkable potential for health benefits Frequent nut consumption associated with less inflammation Body posture affects how oral drugs absorbed by stomach [why not supplements too?] Lifting Weights Beats Out Cycling, Swimming For Vegans Wanting Stronger Bones Perfectionism Linked To Burnout At Work, School And Sports, Research Finds Mindfulness Therapy Better Than Antidepressants Astonishing effects of grapes, remarkable potential for health benefits Western New England University, August 8, 2022 Recent studies released by Dr. John Pezzuto and his team from Western New England University show “astonishing” effects of grape consumption and “remarkable” impacts on health and on lifespans. Published in the journal Foods, one study showed that adding grapes in an amount equal to just under two cups of grapes per day to a high-fat diet, typically consumed in western countries, yielded reductions in fatty liver and extended lifespans. Noting that these studies add an entirely new dimension to the old saying ‘you are what you eat,' Pezzuto, who has authored over 600 scientific studies, said that the work with grapes showed actual changes in genetic expression. “That is truly remarkable.” Adding grapes to a high-fat diet also increased levels of antioxidant genes and delayed natural death. Acknowledging that it is not an exact science to translate years of lifespan from a mouse to a human, Pezzuto said that his best estimate is the change observed in the study would correspond to an additional 4-5 years in the life of a human. Another study by Dr. Pezzuto and his team published in the journal Antioxidants, reported that grape consumption altered gene expression in the brain and had positive effects on behavior and cognition that were impaired by a high-fat diet. Frequent nut consumption associated with less inflammation Brigham and Women's Hospital, August 1, 2022 In a study of more than 5,000 people, investigators from Brigham and Women's Hospital have found that greater intake of nuts was associated with lower levels of biomarkers of inflammation, a finding that may help explain the health benefits of nuts. The results of the study appear in the American Journal of Clinical Nutrition. “Population studies have consistently supported a protective role of nuts against cardiometabolic disorders such as cardiovascular disease and type 2 diabetes, and we know that inflammation is a key process in the development of these diseases,” said corresponding author Ying Bao, MD, ScD, an epidemiologist in BWH's Channing Division of Network Medicine. “Our new work suggests that nuts may exert their beneficial effects in part by reducing systemic inflammation.” In the current study, the research team performed a cross-sectional analysis of data from the Nurses' Health Study, which includes more than 120,000 female registered nurses, and from the Health Professionals Follow-Up Study, which includes more than 50,000 male health professionals. The team assessed diet using questionnaires and looked at the levels of certain telltale proteins known as biomarkers in blood samples collected from the study participants. They measured three well-established biomarkers of inflammation: C-reactive protein (CRP), interleukin 6 (IL6) and tumor necrosis factor receptor 2 (TNFR2). After adjusting for age, medical history, lifestyle and other variables, they found that participants who had consumed five or more servings of nuts per week had lower levels of CRP and IL6 than those who never or almost never ate nuts. In addition, people who substituted three servings per week of nuts in place of red meat, processed meat, eggs or refined grains had significantly lower levels of CRP and IL6. Peanuts and tree nuts contain a number of healthful components including magnesium, fiber, L-arginine, antioxidants and unsaturated fatty acids such as α-linolenic acid. Body posture affects how oral drugs absorbed by stomach [why not supplements too?] Johns Hopkins School of Medicine, August 8, 2022 A common, economic, and easy method of administering drugs is orally, by swallowing a pill or capsule. But oral administration is the most complex way for the human body to absorb an active pharmaceutical ingredient, because the bioavailability of the drug in the gastrointestinal tract depends on the medication's ingredients and the stomach's dynamic physiological environment. In Physics of Fluids, researchers from Johns Hopkins School of Medicine employ a biomimetic in-silico simulator based on the realistic anatomy and morphology of the stomach—a “StomachSim”—to investigate and quantify the effect of body posture and stomach motility on drug bioavailability. “”When the pill reaches the stomach, the motion of the stomach walls and the flow of contents inside determine the rate at which it dissolves. The properties of the pill and the stomach contents also play a major role. Stomach contents, motility, and gastric fluid dynamics all play a role in a drug's bioavailability, and stomach contractions can induce pressure and generate complex pill trajectories. This results in varying rates of pill dissolution and nonuniform emptying of the drug into the duodenum and, sometimes, gastric dumping in the case of modified-release dosage. The modeling appears to be the first of its kind to couple gastric biomechanics of posture with pill movement and drug dissolution to quantify an active pharmaceutical ingredientpassing through the pylorus into the duodenum. The model enabled the researchers to calculate and compare the emptying rate and the release of a dissolved active pharmaceutical ingredient into the duodenum for a variety of physiological situations. Lifting Weights Beats Out Cycling, Swimming For Vegans Wanting Stronger Bones Medical University of Vienna (Austria), August 2, 2022 When it comes to bone health, a new study finds people on a plant-based diet should grab the dumbbells. Researchers in Austria have found that lifting weights is the best form of exercise for vegans – trumping cycling and swimming. The team found that vegans who do resistance training once a week – such as machine-work, free weights, or bodyweight resistance – have stronger bones than plant-based eaters who do other forms of exercise. The new study, published in the Journal of Clinical Endocrinology & Metabolism, found vegans who did resistance training had similar bone structure to omnivores — people who eat both meat and vegetables. For at least five years, authors followed 43 men and women on a plant-based diet and 45 men and women who eat meat as well. “Our study showed resistance training offsets diminished bone structure in vegan people when compared to omnivores.” Perfectionism linked to burnout at work, school and sports, research finds York St. John University (UK), July 31, 2022 Concerns about perfectionism can sabotage success at work, school or on the playing field, leading to stress, burnout and potential health problems, according to new research published by the Society for Personality and Social Psychology. In the first meta-analysis of the relationship between perfectionism and burnout, researchers analyzed the findings from 43 previous studies conducted over the past 20 years. It turns out perfectionism isn't all bad. One aspect of perfectionism called “perfectionistic strivings” involves the setting of high personal standards and working toward those goals in a pro-active manner. These efforts may help maintain a sense of accomplishment and delay the debilitating effects of burnout, the study found. The dark side of perfectionism, called “perfectionistic concerns,” can be more detrimental when people constantly worry about making mistakes, letting others down, or not measuring up to their own impossibly high standards, said lead researcher Andrew Hill, an associate professor of sport psychology at York St. John University in England. Previous research has shown that perfectionistic concerns and the stress they generate can contribute to serious healthproblems, including depression, anxiety, eating disorders, fatigue and even early mortality. The study was published online in the Personality and Social Psychology Review. The study found that perfectionistic concerns had the strongest negative effects in contributing to burnout in the workplace, possibly because people have more social support and clearly defined objectives in education and sports. A student can be rewarded for hard work with a high grade, or a tennis player can win the big match, but a stellar performance in the workplace may not be recognized or rewarded, which may contribute to cynicism and burnout. “People need to learn to challenge the irrational beliefs that underlie perfectionistic concerns by setting realistic goals, accepting failure as a learning opportunity, and forgiving themselves when they fail,” Hill said. “Creating environments where creativity, effort and perseverance are valued also would help.” Mindfulness Therapy Better Than Antidepressants University of Exeter (UK), July 31, 2022 Antidepressants are big business. But for the same money, and without the side effects, a little mindfulness can do the same job. A new study from the University of Exeter in the UK suggests that mindfulness-based cognitive therapy (MBCT) is just as good as drugs – and maybe even better MBCT is a structured training program for the mind and body. It was developed to help people deal with repeated bouts of depression. It teaches them skills to recognize and respond constructively to the thoughts and feelings associated with relapse. In other words, it helps patients re-focus their thoughts as a way to avoid falling back into depression. Prior studies have shown that MBCT reduces the risk of relapse or recurrence of depression by about 34% compared to usual care or placebo. B The research published in The Lancet followed a group of 424 depressed patients for two years. The patients had all suffered three or more previous major depressive episodes. And they were all taking a maintenance course of antidepressants. The MBCT group attended eight group therapy sessions in which they learned mindfulness practices and cognitive-behavioral skills, and participated in group discussions. After two years, relapse rates were worse in the drug group. The drug group relapsed at the rate of 47% compared to only 44% for the mindfulness group. The researchers concluded that MBCT may be an effective alternative to antidepressants for prevention of depressive relapse with no significant difference in cost. And it may be a good alternative for people who choose not to use drugs. But they also suggested MBCT was more beneficial than drugs in preventing relapses in patients who were at highest risk of relapse especially those who reported severe childhood abuse.
Dr Kim Lauper, from the Division of Rheumatology, Department of Internal Medicine and Department of Medicine, Faculty of Medicine, Geneva University Hospitals, Geneve, Switzerland. Join Professor Peter Nash as he interviews authors of recent notable papers in rheumatology. In this addition Dr Lauper discusses her latest paper; Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the ‘JAK-pot' collaboration.
In this episode Clint is back after a month's hiatus and wants to discuss women not really out here hollering at men. They say they are but you aint really bout it like you say you are.Hoochie Daddy Shorts Playlistshttps://linktr.ee/clintcoleyplaylistsMy Edible Kicked In Ticketswww.myediblekickedin.com6/17 Chicago, IL6/25 Oakland, CA6/26 Portland, OR7/8 Detroit, MI7/9 Buffalo, NY7/15 Richmond, VA7/16 Washington, D.C.7/17 Raleigh, NC7/23 Brooklyn, NY
In this episode Clint is by himself again and today he wants to know why men don't seem to be having fun on dates.Hoochie Daddy Shorts Playlistshttps://linktr.ee/clintcoleyplaylistsMy Edible Kicked In Ticketswww.myediblekickedin.com5/20-22 Kansas City, MO6/9 Milwaukee, WI6/10 Milwaukee, WI6/11 St. Louis, MO6/12 Cleveland, OH6/17 Chicago, IL6/18 Minnesota, MN6/25 Oakland, CA6/26 Portland, OR7/8 Detroit, MI7/9 Buffalo, NY7/15 Richmond, VA7/16 Washington, D.C.7/17 Raleigh, NC7/23 Brooklyn, NY
In this episode Clint is by himself and he is discussing Hoochie daddy season. Time to get right fellas.Hoochie Daddy Shorts Playlistshttps://linktr.ee/clintcoleyplaylistsMy Edible Kicked In Ticketswww.myediblekickedin.com5/20-22 Kansas City, MO6/9 Milwaukee, WI6/10 Milwaukee, WI6/11 St. Louis, MO6/12 Cleveland, OH6/17 Chicago, IL6/18 Minnesota, MN6/25 Oakland, CA6/26 Portland, OR7/8 Detroit, MI7/9 Buffalo, NY7/15 Richmond, VA7/16 Washington, D.C.7/17 Raleigh, NC7/23 Brooklyn, NY
This week, please join author Andrew Stokes as he and Greg Hundley discuss the Research Letter "E-Cigarette Use and Risk of Cardiovascular Disease: A Longitudinal Analysis of the PATH Study (2013–2019)." Dr. Greg Hundley: Well, listeners, welcome to this May 17th issue of Circulation on the Run. And I am Dr. Greg Hundley, associate editor, director of the poly heart center at VCU Health in Richmond, Virginia. And this week, Carolyn is away out on vacation and we are going to go through the summaries together. We have a great feature today on e-cigarette use and the risk of cardiovascular disease. But before we get to that, how about we grab a cup of coffee and jump into some of the other articles in the issue? And the first one comes to us from the world of clinical science and Dr. Jiaqi Huang from the National Cancer Institute. Listeners, the objective of this study was to examine overall and cause-specific mortality in relation to dietary and serum cholesterol, as well as egg consumption through the prospective analysis of 27,000 men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention or ATBC Study, and also a systematic review and meta-analysis of several other cohort studies. Dr. Greg Hundley: So, what did the investigators find? Well, first, based on 482,000 person-years of follow-up, the authors identified 22,000 deaths, including 9,110 deaths from cardiovascular disease. Now, greater dietary cholesterol and egg consumption were associated with increased risk of overall and cardiovascular disease mortality. Now, second, from the meta-analysis component of the study, overall consumption of one additional 50-gram egg per day was associated with an increased cardiovascular disease risk with a pooled relative risk of 1.04 with a higher risk of cardiovascular disease among those from us cohorts where their pooled relative risk ratio was 1.88, a borderline higher cardiovascular disease risk in European cohorts with a pooled relative risk of 1.05, but not an increased cardiovascular disease risk in the Asian cohorts. So, the results from this study, which includes an updated meta-analysis, suggest that there is support for restricted consumption of dietary cholesterol as really a means to improve long-term health and longevity. Dr. Greg Hundley: Well, let's go to our next article. So, in this next study, we are going to move from cholesterol risk now to salt substitution. And this article comes to us from Professor Maoyi Tian from the Harbin Medical University. Listeners, the Salt Substitute and Stroke Study, or SSaSS is a five-year cluster randomized controlled trial and demonstrated that replacing regular salt with a reduced sodium added or potassium salt substitute reduced the risk of stroke, major cardiovascular events, and premature death among individuals with prior stroke or uncontrolled high blood pressure that lived in rural China. So, this particular study, a substudy, assessed the cost-effectiveness profile of this particular intervention. Dr. Greg Hundley: So, listeners, what did the study find? Well, there was a mean follow-up of 20,995 participants that was conducted a little over four years, and over the period, replacing regular salt with salt substitute reduced the risk of stroke by 14% and the salt substitute group had on average 0.054 more quality-adjusted life years per person. The average costs were lower in the salt substitute group, and this intervention was dominant. That is better outcomes at a lower cost for prevention of stroke as well as for quality-adjusted life-years gained. Now, interestingly sensitivity analyses showed that these conclusions were robust except when the price of the salt substitute was increased to the median and highest market prices identified in China. The salt substitute intervention had a 95% probability of being cost-saving and a greater than 99.9% probability of being cost-effective. A really interesting article. Dr. Greg Hundley: Well, now, let's turn our attention to the world of population science. And in this study, these authors led by Dr. Steven Lubitz from Massachusetts General Hospital performed a Genome-Wide Association Study or GWAS of the QT corrected interval among 84,630 United Kingdom Biobank participants. And they created a polygenic risk score. Now, among 26,976 participants with whole-genome sequencing and electrocardiogram data in the Trans-Omics for Precision Medicine or TOPMed program, they identified 160 carriers of punitive pathogenic, rare variants in 10 genes known to be associated with the QT interval. Dr. Greg Hundley: So, the authors here examined the QTC corrected associations with the polygenic risk score and with rare variants from the TOPMed cohort. So, what did they find? They found 54 independent loci by GWAS in the UK Biobank. 21 loci were novel of which 12 were replicated in TOPMed. The polygenic risk score comprising over a million common variants was significantly associated with the QTC in TOPMed, and carriers of punitive pathogenic rare variants had longer QTC intervals than non-carriers. Now, 23.7% of individuals with a QT corrected of greater than 480 milliseconds carried either a monogenic rare variant or had a polygenic risk score in the top decile. 3.4% for monogenic and 21% for the top decile of the polygenic risk score. Dr. Greg Hundley: So, listeners, the findings of this study indicate that the QTC duration in the population is influenced by both rare variants in genes, underlying cardiac repolarization and polygenic risk, with a sizeable additional contribution from polygenic risk. And therefore, comprehensive assessment of the genetic determinants of QTC prolongation should include incorporation of both polygenic and monogenic risk. Dr. Greg Hundley: Well, listeners, let's turn our attention to the world of preclinical science. And this next article comes to us from Professor Junbo Ge from the Department of Cardiology in Zhongshan Hospital in Fudan University. Well, listeners, after myocardial infarction, cardiac resident macrophages, which are self-maintaining in that they originate from embryonic hematopoiesis are responsible for the efficient clearance and degradation of apoptotic cardiomyocytes. And that process is called efferocytosis. Now, efferocytosis is required for inflammation resolution and tissue repair. However, the underlying molecular mechanisms of this process really remain unknown. Dr. Greg Hundley: So, as such, listeners, these authors sought to identify the mechanisms of the continued clearance and degradation of phagolysosomal cargo by cardiac resident macrophages during myocardial infarction. Well, what did Dr. Ge and colleagues find? Several things. First, they identified legumine as a gene specifically expressed by cardiac resident macrophages, and legumine deficiency resulted in a considerable exacerbation in cardiac function, accompanied with the accumulation of apoptotic cardiomyocytes and a reduced index of in-vivo efferocytosis in the border area of infarcts. Furthermore, the formation of LC3 to dependent phagosome around secondary encountered apoptotic cardiomyocytes was disabled. In addition, legumine deficiency increased infiltration of MHC to high CCR2+ macrophages, and the enhancement of recruitment of MHC to low CCR2+ monocytes with downregulation of anti-inflammatory mediators, such as IL10 and TGF-beta, and upregulation of pro-inflammatory mediators, including interleukin-1-beta, Tumor Necrosis Factor alpha, IL6, and IFN-gamma. Dr. Greg Hundley: So, listeners, in summary, the results of this study directly link efferocytosis to wound healing in the heart and identify legumine as a significant link between acute inflammation resolution and cardiac function after infarction. Well, listeners, also in this issue, we have a wonderful On My Mind feature from Professor Camlet entitled “A Role for the Vascular Endothelium in Post-Acute COVID-19.” Well, next, we're going to head to our feature article on e-cigarette use and the risk of cardiovascular disease. Dr. Greg Hundley: Well, listeners, welcome to our feature discussion today. A very interesting topic. E-cigarette use and the risk of cardiovascular disease. And we have with us today the senior author of this particular manuscript, Dr. Andrew Stokes from the Boston University School of Public Health in Boston, Massachusetts. Welcome, Andrew. Andrew, to get started, can you describe some of the background information pertaining to your study and what was the hypothesis that you wanted to address? Dr. Andrew Stokes: Absolutely, and thank you for having me on the podcast. Despite the increasing popularity of electronic cigarettes, the long-term health effects of habitual e-cigarette use remain unclear. Most of the studies that have been conducted to date are either cross-sectional or they pertain to small clinical samples. The goal of the present study was to develop a longitudinal design to see if e-cigarette use at a point in time was linked to cardiovascular events over a multi-year follow-up period. Dr. Greg Hundley: Very nice. So, your specific hypothesis really pertained to e-cigarette use, correct? Dr. Andrew Stokes: That's right. As a novel product, information on e-cigarette use and its health effects is lacking, and so our goal was to see if e-cigarette use was associated with the incidence of clinical events. Dr. Greg Hundley: And so, can you describe for us your study population and your study design? Dr. Andrew Stokes: Absolutely. Data come from the Population Assessment of Tobacco and Health Study or the PATH Study, which is a nationally representative cohort study of the non-institutionalized population containing five annual waves of self-reported data collected between 2013 and 2019. The initial sample included over 30,000 US adults ages 18 years and older with oversampling of tobacco users. We excluded respondents who were lost to follow-up or who had a previous diagnosis of CVD or were missing baseline exposure information. Ultimately, we ended up with a sample of just over 20,000 individuals. Dr. Greg Hundley: Very nice. And so, what were your study results? Dr. Andrew Stokes: So, we had several key findings. One key finding was that, compared to people who only smoke cigarettes, people who smoke both traditional cigarettes and used e-cigarettes had no significant reduction in risk for heart attack, heart failure, or stroke, nor any cardiovascular disease outcome. This is significant because many e-cigarette users use both e-cigarettes and cigarettes in combination. Very few move to exclusive e-cigarette use. Additionally, we found that those who do move to e-cigarette use exclusively though, representing a very small fraction of the cohort, had some evidence of reduction in cardiovascular harm. However, these results for exclusive e-cigarette users were not statistically significant, indicating that additional studies with longer follow-up will be required before we can make any definitive conclusions about this group. Dr. Greg Hundley: Very nice. And did you notice any discrepancy in your results between either men versus women or between individuals that were younger in age versus those that may say be 50 years or older? Dr. Andrew Stokes: I think both sources of effect modification will be valuable directions for future research. Unfortunately, samples of e-cigarette users are quite small and incident events over follow-up are quite limited. Therefore, the present study did not pursue or explore these types of stratifications. Dr. Greg Hundley: Very good. So, sounds like more research to come forward. Well, Andrew, how do we put your results really in the context with other studies evaluating the harmful effects of e-cigarettes? Dr. Andrew Stokes: Of course. So, we know from toxicological studies that there are many constituents of e-cigarette aerosols that are concerning and have substantial toxicity. We know that the inhalation of e-cigarette aerosols among young healthy adults induce inflammation and oxidative stress. Population-based studies from cross-sectional data sources also suggest evidence of harm. What's needed are more longitudinal studies with longer follow-up periods and more incidence events so we can really parse this risk and identify the magnitude of these harms. Finally, we also need to understand better whether there's any harm reduction potential associated with e-cigarette use. E-cigarettes are currently not an FDA-approved cessation product. Therefore, we do not recommend their use despite preliminary evidence of potential harm reduction. We'll need further evidence before we can make any such conclusions. Dr. Greg Hundley: And Andrew, describe for us, and you've started to already, what series of studies are needed next to be performed in this sphere of research? Dr. Andrew Stokes: Right. So, it's difficult to really identify definitively the effects of e-cigarette use in the absence of randomized control trials. However, we can use observational data with target trial approaches to emulate the clinical trial that we would like to do if we were able to. So, the next step is really to look at transitions across products between cigarette and e-cigarette use and to associate those who switch products, such as from e-cigarettes to cigarettes or vice versa, to see if those switches are associated with any harm or harm reduction. Dr. Greg Hundley: Very good. Any specific racial or ethnic groups or even social determinants of health that may need to be targeted with some of these future studies? Dr. Andrew Stokes: That's a great question. So, what we know so far from preliminary research is that some groups are more likely to switch to e-cigarettes than other groups. Particularly among current combustible cigarette users, the rates of switching do vary by race and ethnicity. Thus, we need further research to understand why these patterns differ across subgroups and what their implications may be for health. Dr. Greg Hundley: Do you foresee any difficulty in trying to enroll participants from those other groups as you plan these studies moving forward? Dr. Andrew Stokes: The advantage of the current research design is that we're using a large secondary data set of survey participants who are enrolled in the Population Assessment of Tobacco and Health study. Therefore, we are not enrolling patients ourselves and the response rates are quite high in these surveys. Dr. Greg Hundley: Well, Andrew, we hear that some of the inhalants that are mixed with the inhaled nicotine can be flavors and perhaps have been approved by the FDA for consumption in the GI tract where, whatever these additives are, you would think might be broken down by the digestive system. But if they're inhaled and get into the lung tissue and the parenchyma, the alveoli, et cetera, do they perhaps have harmful effects that maybe we're not aware of? Dr. Andrew Stokes: Absolutely. E-cigarettes come in thousands of characterizing flavors including sweet flavors, tobacco flavors, and many other miscellaneous flavors. As we saw with the outbreak of lung injury associated with the use of e-cigarettes in 2019, inhaling flavors can have health effects that are unanticipated based on research in the GI tract, and therefore, as a next step in this research, we really need more work to investigate how different flavors are associated with the incidence of clinical events, whether cardiovascular or pulmonary conditions. Dr. Greg Hundley: Very nice. Well, listeners, we want to thank Dr. Andrew Stokes from the Boston University School of Health for bringing us this data from the PATH study, suggesting that combining smoking with e-cigarette use does not reduce cardiovascular events and that quitting both products is needed to ensure overall cardiovascular disease risk reduction. Dr. Greg Hundley: Well, on behalf of Carolyn and myself, we want to wish you a great week and we will catch you next week on the run. This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, please visit ahajournals.org.
In this episode Clint discusses Kevin Samuels.Hoochie Daddy Shorts At Night Playlisthttps://linktr.ee/clintcoleyplaylistsMy Edible Kicked In Ticketswww.myediblekickedin.com4/14 Boston, MA4/15 Philadelphia, PA4/20 Memphis, TN4/21 Houston, TX4/22 New Orleans, LA4/28 Syracuse, NY4/29 Toronto, ON5/5 Seattle, WA5/6 Vancouver, BC5/12 Indianapolis, IN5/13 Cincinnati, OH5/20-22 Kansas City, MO6/9 Milwaukee, WI6/10 Milwaukee, WI6/11 St. Louis, MO6/12 Cleveland, OH6/17 Chicago, IL6/18 Minnesota, MN6/25 Oakland, CA6/26 Portland, OR7/8 Detroit, MI7/9 Buffalo, NY7/15 Richmond, VA7/16 Washington, D.C.7/17 Raleigh, NC7/23 Brooklyn, NY
In this episode Clint is alone and discussing why men hate dating so much.After Breakfast Playlisthttps://linktr.ee/clintcoleyplaylistsBreakfast Date Playlist.My Edible Kicked In Ticketswww.myediblekickedin.com4/14 Boston, MA4/15 Philadelphia, PA4/20 Memphis, TN4/21 Houston, TX4/22 New Orleans, LA5/5 Seattle, WA5/6 Vancouver, BC5/12 Indianapolis, IN5/13 Cincinnati, OH5/20-22 Kansas City, MO6/9 Milwaukee, WI6/10 Milwaukee, WI6/11 St. Louis, MO6/12 Cleveland, OH6/17 Chicago, IL6/18 Minnesota, MN6/25 Oakland, CA6/26 Portland, OR7/8 Detroit, MI7/9 Buffalo, NY7/10 Toronto, ON7/15 Richmond, VA7/16 Washington, D.C.7/17 Raleigh, NC7/23 Brooklyn, NY
In this episode Clint is joined by Slink Johnson and they are trying to figure out how men are giving quality penis and not getting rewarded with quality snacks.After Breakfast Playlisthttps://linktr.ee/clintcoleyplaylistsFollow Slink Johnson@slinkjohnsonBreakfast Date Playlist.My Edible Kicked In Ticketswww.myediblekickedin.com4/14 Boston, MA4/15 Philadelphia, PA4/20 Memphis, TN4/21 Houston, TX4/22 New Orleans, LA5/5 Seattle, WA5/6 Vancouver, BC5/12 Indianapolis, IN5/13 Cincinnati, OH5/20-22 Kansas City, MO6/9 Milwaukee, WI6/10 Milwaukee, WI6/11 St. Louis, MO6/12 Cleveland, OH6/17 Chicago, IL6/18 Minnesota, MN6/25 Oakland, CA6/26 Portland, OR7/8 Detroit, MI7/9 Buffalo, NY7/10 Toronto, ON7/15 Richmond, VA7/16 Washington, D.C.7/17 Raleigh, NC7/23 Brooklyn, NY
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In this episode Clint is joined by podcast favorite Louis Gee and they discuss why people are out here dating and only thinking about themselves.After Breakfast Playlisthttps://linktr.ee/clintcoleyplaylistsFollow Louis Gee@lougee83Breakfast Date Playlist.My Edible Kicked In Ticketswww.myediblekickedin.com4/14 Boston, MA4/15 Philadelphia, PA4/20 Memphis, TN4/21 Houston, TX4/22 New Orleans, LA4/28 Syracuse, NY4/29 Toronto, ON5/5 Seattle, WA5/6 Vancouver, BC5/12 Indianapolis, IN5/13 Cincinnati, OH5/20-22 Kansas City, MO6/9 Milwaukee, WI6/10 Milwaukee, WI6/11 St. Louis, MO6/12 Cleveland, OH6/17 Chicago, IL6/18 Minnesota, MN6/25 Oakland, CA6/26 Portland, OR7/8 Detroit, MI7/9 Buffalo, NY7/15 Richmond, VA7/16 Washington, D.C.7/17 Raleigh, NC7/23 Brooklyn, NY
In this episode Clint sits down with his friend, singer and songwriter Steph and they discuss why women want to feel special even if you two just met.After Breakfast Playlisthttps://linktr.ee/clintcoleyplaylistsFollow Steph@soundslikestephBreakfast Date Playlist.My Edible Kicked In Ticketswww.myediblekickedin.com4/14 Boston, MA4/15 Philadelphia, PA4/20 Memphis, TN4/21 Houston, TX4/22 New Orleans, LA4/28 Syracuse, NY4/29 Toronto, ON5/5 Seattle, WA5/6 Vancouver, BC5/12 Indianapolis, IN5/13 Cincinnati, OH5/20-22 Kansas City, MO6/9 Milwaukee, WI6/10 Milwaukee, WI6/11 St. Louis, MO6/12 Cleveland, OH6/17 Chicago, IL6/18 Minnesota, MN6/25 Oakland, CA6/26 Portland, OR7/8 Detroit, MI7/9 Buffalo, NY7/15 Richmond, VA7/16 Washington, D.C.7/17 Raleigh, NC7/23 Brooklyn, NY
In this episode Clint and Tahir Moore teach the fellas how to make a playlist and they have a discussion about the last 2 years have been hard.After Breakfast Playlisthttps://linktr.ee/clintcoleyplaylistsFollow Tahir Moore@tahirmooreBreakfast Date Playlist.My Edible Kicked In Ticketswww.myediblekickedin.com4/14 Boston, MA4/15 Philadelphia, PA4/20 Memphis, TN4/21 Houston, TX4/22 New Orleans, LA4/28 Syracuse, NY4/29 Toronto, ON5/5 Seattle, WA5/6 Vancouver, BC5/12 Indianapolis, IN5/13 Cincinnati, OH5/20-22 Kansas City, MO6/9 Milwaukee, WI6/10 Milwaukee, WI6/11 St. Louis, MO6/12 Cleveland, OH6/17 Chicago, IL6/18 Minnesota, MN6/25 Oakland, CA6/26 Portland, OR7/8 Detroit, MI7/9 Buffalo, NY7/15 Richmond, VA7/16 Washington, D.C.7/17 Raleigh, NC7/23 Brooklyn, NY
In this episode Clint is with fellow comedian and friend Isiah Kelly and they are schooling you on what men discuss among themselves as well as what you need to do on a breakfast date. Playlist belowAfter Breakfast Playlisthttps://linktr.ee/clintcoleyplaylistsFollow Isiah Kelly@isiahkellyBreakfast Date Playlist.My Edible Kicked In Ticketswww.myediblekickedin.com4/14 Boston, MA4/15 Philadelphia, PA4/20 Memphis, TN4/21 Houston, TX4/22 New Orleans, LA4/28 Syracuse, NY4/29 Toronto, ON5/5 Seattle, WA5/6 Vancouver, BC5/12 Indianapolis, IN5/13 Cincinnati, OH5/20-22 Kansas City, MO6/9 Milwaukee, WI6/10 Milwaukee, WI6/11 St. Louis, MO6/12 Cleveland, OH6/17 Chicago, IL6/18 Minnesota, MN6/25 Oakland, CA6/26 Portland, OR7/8 Detroit, MI7/9 Buffalo, NY7/15 Richmond, VA7/16 Washington, D.C.7/17 Raleigh, NC7/23 Brooklyn, NY
In this episode Clint is with fellow comedian and friend Malik S and they finish the conversation about which cities have the best women. Also, how long does someone have to be locked up before you realize that you're single.Follow Malik S@malikscomedyMy Edible Kicked In Ticketswww.myediblekickedin.com4/14 Boston, MA4/15 Philadelphia, PA4/20 Memphis, TN4/21 Houston, TX4/22 New Orleans, LA4/28 Syracuse, NY4/29 Toronto, ON5/5 Seattle, WA5/6 Vancouver, BC5/12 Indianapolis, IN5/13 Cincinnati, OH5/20-22 Kansas City, MO6/9 Milwaukee, WI6/10 Milwaukee, WI6/11 St. Louis, MO6/12 Cleveland, OH6/17 Chicago, IL6/18 Minnesota, MN6/25 Oakland, CA6/26 Portland, OR7/8 Detroit, MI7/9 Buffalo, NY7/15 Richmond, VA7/16 Washington, D.C.7/17 Raleigh, NC7/23 Brooklyn, NY
My Edible Kicked In Ticketswww.myediblekickedin.com4/14 Boston, MA4/15 Philadelphia, PA4/20 Memphis, TN4/21 Houston, TX4/22 New Orleans, LA4/28 Syracuse, NY4/29 Toronto, ON5/5 Seattle, WA5/6 Vancouver, BC5/12 Indianapolis, IN5/13 Cincinnati, OH5/20-22 Kansas City, MO6/9 Milwaukee, WI6/10 Milwaukee, WI6/11 St. Louis, MO6/12 Cleveland, OH6/17 Chicago, IL6/18 Minnesota, MN6/25 Oakland, CA6/26 Portland, OR7/8 Detroit, MI7/9 Buffalo, NY7/15 Richmond, VA7/16 Washington, D.C.7/17 Raleigh, NC7/23 Brooklyn, NY
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