Podcasts about Reproductive biology

There have been various publications and commentaries published on “evidence-based” cesarean section techniques. Still, one of the persistent controversies on abdominal wall closure relates to the rectus. With transverse fascial entries, should we close/reapproximate the rectus or not? In June 2025, a new RCT looking at this very issue will be printed in the European J Obstetrics Gynecology and Reproductive Biology. Listen in for details.

Teresa K. Woodruff joined an elite group of Americans who have received two national medals of honor when President Joe Biden announced the latest recipients of the National Medal of Science on Jan. 3.  Arati Prabhakar, director of the White House Office of Science and Technology Policy, presented Woodruff with the medal at a ceremony at the Eisenhower Executive Office Building in Washington, D.C., on the same date. The first person from Michigan State University to receive the National Medal of Science, Woodruff has made significant global contributions in scientific research, improvements to the scientific process and diversification of research teams. Woodruff is an MSU Foundation professor in both the Department of Obstetrics, Gynecology and Reproductive Biology at MSU's College of Human Medicine and the Department of Biomedical Engineering at MSU's College of Engineering. She was named provost of MSU in August 2020 and served as interim president of MSU from 2022-2024.   Established in 1959 by the U.S. Congress, the National Medal of Science is the highest recognition the nation can bestow on scientists and engineers. Teresa is the first MSU faculty member to receive the recognition.   President Barack Obama presented Woodruff with the Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring in an Oval Office ceremony in 2011. It is very rare to receive two presidential honors.   Conversation Highlights: (1:36) - Congratulations! How does it feel? (2:30) - You're one of the world's leading fertility experts, and you pioneered the science of oncofertility in 2006 that has helped thousands of cancer patients protect their reproductive futures. Talk about how your interest in this area developed and describe your research interests. (4:43) - How is your research evolving? Findings lead to more questions, right? What is the zinc spark? (6:37) - Teaching and mentoring are important to you. You're an advocate for women in science and led efforts to change federal policy to mandate the use of females in fundamental National Institutes of Health research.Your students inspire you. Why is mentoring important to you and how are they helping carry on your work? (8:57) - Why MSU? You could do this research anywhere.  (9:57) – The burgeoning MSU Health Sciences. Listen to “MSU Today with Russ White” on the radio and through Spotify, Apple Podcasts, and wherever you get your shows.

Sviluppato un software basato sull’intelligenza artificiale che potrà essere incorporato a un ecografo e ‘guidare’ il parto, fornendo informazioni precise e in tempo reale sulla posizione della testa del bebè e quindi suggerendo, in maniera chiara con un semaforo, agli operatori se procedere con la discesa naturale nel canale del parto, se usare la ventosa o se, addirittura, sia meglio passare a un cesareo d’urgenza. Lo strumento, che potrebbe arrivare in sala parto a partire dal 2028, è stato sviluppato e validato nell’ambito di un lavoro pubblicato su The European Journal of Obstetrics & Gynecology and Reproductive Biology, coordinato dal professor Tullio Ghi, ordinario di Ginecologia e Ostetricia presso l'Università Cattolica, campus di Roma, e Direttore della Unità Operativa Complessa di Ostetricia del Policlinico Universitario Agostino Gemelli IRCCS, ospite di Nicoletta Carbone a Obiettivo Salute.

In this episode, we delve into the remarkable benefits of colostrum and how it can support hormone balance across various stages of a woman's life. From improving period health to promoting a healthy pregnancy, aiding postpartum recovery, and regulating hormones during perimenopause, colostrum's nutrient-rich properties make it an effective tool for women seeking natural solutions. We'll discuss how colostrum works at the cellular level, with scientific insights on its anti-inflammatory effects, gut health benefits, and hormone-regulating capabilities. Berri's Favorite Colostrum & Save with Code: BERRION Key Topics Discussed: 1. How Colostrum Improves Period Health Gut Barrier Repair: Colostrum contains growth factors like IGF-1 and TGF-β that aid in repairing the gut lining, preventing "leaky gut." A healthy gut helps metabolize and eliminate excess hormones, reducing PMS symptoms. Reducing Inflammation: Anti-inflammatory compounds like lactoferrin decrease inflammation, alleviating menstrual cramps and pelvic pain. Enhancing Nutrient Absorption: Colostrum supports better absorption of magnesium and vitamin B6, which are essential for mood stability and reducing PMS symptoms. 2. Colostrum's Role in Promoting a Healthy Pregnancy Immune Modulation: Immunoglobulins in colostrum help balance the immune response, protecting the mother and developing baby from pathogens without causing excessive inflammation. Nutrient Absorption: Supports the growth of beneficial gut bacteria to enhance absorption of vital nutrients like calcium, iron, and folate, crucial for fetal development. Growth Factors for Fetal Development: Contributes to the development of essential organs, such as the lungs and gut, potentially reducing the risk of preterm birth. 3. Easing Postpartum Recovery with Colostrum Tissue Healing: Growth factors aid in repairing tissues affected by childbirth, speeding up recovery. Hormone Metabolism and Mood Stability: Supports the breakdown and elimination of excess hormones, helping stabilize hormone levels post-delivery. Immune Support: Boosts immunity with compounds like lactoferrin, enhancing the body's defense against infections during the postpartum period. 4. Regulating Hormones During Perimenopause Improving Insulin Sensitivity: Helps stabilize blood sugar levels by improving insulin sensitivity, which can alleviate fatigue and irritability. Gut Health and Hormone Detoxification: Assists in the elimination of hormones like estrogen, reducing symptoms of estrogen dominance. Anti-Aging and Tissue Repair: Supports tissue regeneration, countering symptoms associated with aging, such as thinning skin or joint discomfort. Episode Highlights: Colostrum's Unique Nutrients: Why this pre-milk fluid is more than just a newborn's first food. Scientific Evidence: Insights from studies on colostrum's role in inflammation, gut health, and hormonal balance. Practical Tips: How to incorporate high-quality colostrum supplements into your routine. Resources Mentioned: Studies cited from journals such as Reproductive Biology and Endocrinology, Journal of Obstetrics and Gynaecology, and International Journal of Immunopathology and Pharmacology.

Do you prefer multistory episodes, single story episodes, or a mix? Let us know! In this episode of 'Discover Daily' by Perplexity, hosts Alex and Sienna explore groundbreaking discoveries in reproductive biology and the world's longest-running laboratory experiment. They delve into how researchers used the Nobel Prize-winning AI tool AlphaFold to identify a trimeric protein complex on sperm that functions as a molecular "key" in vertebrate fertilization. This discovery could revolutionize our understanding of fertility and potentially lead to new treatments for infertility.Finally, Alex and Sienna then take a deep dive into the fascinating Pitch Drop Experiment, initiated in 1927 at the University of Queensland. They explore how this experiment, which demonstrates the surprising fluidity of pitch, has captivated scientists and the public for nearly a century. The hosts discuss the experiment's latest findings, its implications for materials science, and what it reveals about the nature of seemingly solid substances.Perplexity is the fastest and most powerful way to search the web. Perplexity crawls the web and curates the most relevant and up-to-date sources (from academic papers to Reddit threads) to create the perfect response to any question or topic you're interested in. Take the world's knowledge with you anywhere. Available on iOS and Android Join our growing Discord community for the latest updates and exclusive content. Follow us on: Instagram Threads X (Twitter) YouTube Linkedin

La fecondazione in vitro richiede particolari attenzioni fisiche, ma l'attività fisica può essere una preziosa alleata se dosata correttamente. Analizziamo come gestire l'allenamento durante e dopo la FIVET, evitando eccessi che potrebbero compromettere la salute riproduttiva e pianificando attività a basso impatto per mantenere forza e flessibilità. Segui Postura Da Paura su Instagram e Facebook per trovare altri consigli e informazioni per vivere una vita più equilibrata e serena. Per noi il movimento è una medicina naturale, visita il sito www.posturadapaura.com per trovare il programma di allenamento più adatto alle tue esigenze. Come promesso ecco le fonti citate durante la puntata: Rao, Meng, Zhengyan Zeng, and Li Tang. “Maternal physical activity before IVF/ICSI cycles improves clinical pregnancy rate and live birth rate: a systematic review and meta-analysis.” Reproductive Biology and Endocrinology 16 (2018): 1-8. Northern California Fertility Medical Center, “IVF and Exercise: 6 Tips for a Successful and Healthy Pregnancy”, Aggiornato al 26/04/2023 Carolinas Fertility Institute, “5 Guidelines for Exercise and Fertility Treatments”, 30/06/2020 Humanitas, “Fertilizzazione in vitro (FIVET)”, Aggiornato al 26/04/2023 Los Angeles IVF Clinic, “Should you avoid sports during fertility treatment”, 15/12/2020

Presented in partnership with Fertility and Sterility onsite at the 2024 ANZSREI meeting in Sydney, Australia.  The ANZSREI 2024 debate discussed whether patients with unexplained infertility should go straight to IVF. Experts on both sides weighed the effectiveness, cost, and psychological impact of IVF versus alternatives like IUI. The pro side emphasized IVF's high success rates and diagnostic value, while the con side argued for less invasive, cost-effective options. The debate highlighted the need for individualized care, with no clear consensus reached among the audience. View Fertility and Sterility at https://www.fertstert.org/ TRANSCRIPT: Welcome to Fertility and Sterility On Air, the podcast where you can stay current on the latest global research in the field of reproductive medicine. This podcast brings you an overview of this month's journal, in-depth discussion with authors, and other special features. F&S On Air is brought to you by Fertility and Sterility family of journals in conjunction with the American Society for Reproductive Medicine, and is hosted by Dr. Kurt Barnhart, Editor-in-Chief, Dr. Eve Feinberg, Editorial Editor, Dr. Micah Hill, Media Editor, and Dr. Pietro Bordoletto, Interactive Associate-in-Chief. I'd just like to say welcome to our third and final day of the ANZSREI conference. We've got our now traditional F&S podcast where we've got an expert panel, we've got our international speaker, Pietro, and we've got a wonderful debate ahead of us. This is all being recorded. You're welcome, and please think of questions to ask the panel at the end, because it's quite an interactive session, and we're going to get some of the best advice on some of the really controversial areas, like unexplained infertility. Hi, everyone. Welcome to the second annual Fertility and Sterility Journal Club Global, coming to you live from the Australia and New Zealand Society for Reproductive Endocrinology and Infertility meeting. I think I speak on behalf of everyone at F&S that we are so delighted to be here. Over the last two years, we've really made a concerted effort to take the podcast on the road, and this, I think, is a nice continuation of that. For the folks who are tuning in from home and listening to this podcast after the fact, the Australia and New Zealand Society for Reproductive Endocrinology is a group of over 100 certified reproductive endocrinologists across Australia and New Zealand, and this is their annual meeting live in Sydney, Australia. Today's debate is a topic that I think has vexed a lot of individuals, a lot of patients, a lot of professional groups. There's a fair amount of disagreement, and today we're going to try to unpack a little bit of unexplained infertility, and the question really is, should we be going straight to IVF? As always, we try to anchor to literature, and there are two wonderful documents in fertility and sterility that we'll be using as our guide for discussion today. The first one is a wonderful series that was published just a few months ago in the May issue, 2024, that is a views and reviews section, which means there's a series of three to five articles that kind of dig into this topic in depth. And the second article is our professional society guideline, the ASRM Committee Opinion, entitled Evidence-Based Treatments for Couples with Unexplained Infertility, a guideline. The format for today's discussion is debate style. We have a group of six experts, and I've asked them to randomly assign themselves to a pro and a con side. So I'll make the caveat here that the things that they may be saying, positions they may be trying to influence us on, are not necessarily things that they believe in their academic or clinical life, but for the purposes of a rich debate, they're going to have to be pretty deliberate in convincing us otherwise. I want to introduce my panel for today. We have on my immediate right, Dr. Raewyn Tierney. She's my co-moderator for tonight, and she's a practicing board-certified fertility specialist at IVF Australia. And on my immediate left, we have the con side. Going from left to right, Dr. Michelle Quick, practicing board-certified fertility specialist at IVF Australia. Dr. Robert LaHood, board-certified reproductive endocrinologist and clinical director of IVF Australia here in Sydney. And Dr. Clara Bothroyd, medical director at Care Fertility and the current president of the Asia Pacific Initiative in Reproduction. Welcome. On the pro side, going from right to left, I have Dr. Aurelia Liu. She is a practicing board-certified fertility specialist, medical director of Women's Health Melbourne, and clinical director at Life Fertility in Melbourne. Dr. Marcin Stankiewicz, a practicing board-certified fertility specialist and medical director at Family Fertility Centre in Adelaide. And finally, but certainly not least, the one who came with a tie this morning, Dr. Roger Hart, who is a professor of reproductive medicine at the University of Western Australia and the national medical director of City Fertility. Welcome, pro side. Thank you.  I feel naked without it. APPLAUSE I've asked both sides to prepare opening arguments. Think of this like a legal case. We want to hear from the defence, we want to hear from the plaintiffs, and I'm going to start with our pro side. I'd like to give them a few minutes to each kind of introduce their salient points for why we should be starting with IVF for patients with unexplained infertility. Thanks, Pietro. To provide a diagnosis of unexplained infertility, it's really a reflection of the degree investigation we've undertaken. I believe we all understand that unexplained infertility is diagnosed in the presence of adequate intercourse, normal semen parameters, an absence ovulatory disorder, patent fallopian tubes, and a normal detailed pelvic ultrasound examination. Now, the opposing team will try to convince you that I have not investigated the couple adequately. Personally, I'm affronted by that suggestion. But what possible causes of infertility have I not investigated? We cannot assess easily sperm fertilising capability, we cannot assess oocyte quality, oocyte fertilisation potential, embryonic development, euploidy rate, and implantation potential. Surely these causes of unexplained fertility will only become evident during an IVF cycle. As IVF is often diagnostic, it's also a therapeutic intervention. Now, I hear you cry, what about endometriosis? And I agree, what about endometriosis? Remember, we're discussing unexplained infertility here. Yes, there is very good evidence that laparoscopic treatment for symptomatic patients with endometriosis improves pelvic pain, but there is scant evidence that a diagnostic laparoscopy and treating any minor disease in the absence of pain symptoms will improve the chance of natural conception, or to that matter, improve the ultimate success of IVF. Indeed, in the absence of endometriomas, there is no negative impact on the serum AMH level in women with endometriosis who have not undergone surgery. Furthermore, there is no influence on the number of oocytes collected in an IVF cycle, the rate of embryonic aneuploidy, and the live birth rate after embryo transfer. So why put the woman through a painful, possibly expensive operation with its attendant risks as you're actually delaying her going straight to IVF? What do esteemed societies say about a diagnostic laparoscopy in the setting of unexplained infertility? The ESHRE guidelines state routine diagnostic laparoscopy is not recommended for the diagnosis of unexplained infertility. Indeed, our own ANZSREI consensus statement says that for a woman with a minimal and mild endometriosis, that the number of women needed to treat for one additional ongoing pregnancy is between 3 and 100 women with endometriosis. Is that reasonable to put an asymptomatic woman through a laparoscopy for that limited potential benefit? Now, regarding the guidelines for unexplained infertility, I agree the ASRM guidelines do not support IVF as a first-line therapy for unexplained infertility for women under 37 years of age. What they should say, and they don't, is that it is assumed that she is trying for her last child. There's no doubt if this is her last child, if it isn't her last child, sorry, she will be returning, seeking treatment, now over 37 years of age, where the guidelines do state there is good evidence that going straight to IVF may be associated with higher pregnancy rates, a shorter time to pregnancy, as opposed to other strategies. They then state it's important to note that many of these included studies were conducted in an area of low IVF success rates than those currently observed, which may alter this approach, suggesting they do not even endorse their own recommendations. The UK NICE guidelines, what do they say for unexplained infertility? Go straight to IVF. So while you're listening to my esteemed colleagues on my left speaking against the motion, I'd like to be thinking about other important factors that my colleagues on my right will discuss in more detail. Consider the superior efficacy of IVF versus IUI, the excellent safety profile of IVF and its cost-effectiveness. Further, other factors favouring a direct approach to IVF in the setting of unexplained infertility are what is the woman's desired family? We should not be focusing on her first child, we should be focusing on giving her the family that she desires and how we can minimise her inconvenience during treatment, as this has social, career and financial consequences for those impediments for her while we attempt to help her achieve her desired family. Thank you. APPLAUSE I think the young crowd would say that that was shots fired. LAUGHTER Con side? We're going to save the rebuttal for the time you've allocated to that, but first I want to put the case about unexplained infertility. Unexplained infertility in 2024 is very different to what it was 10 and 20 years ago when many of the randomised controlled trials that investigated unexplained infertility were performed. The armamentarium of investigative procedures and options that we have has changed, as indeed has our understanding of the mechanisms of infertility. So much so that that old definition of normal semen analysis, normal pelvis and ovulatory, which I think was in Roy Homburg's day, is now no longer fit for purpose as a definition of unexplained infertility. And I commend to you ICMART's very long definition of unexplained infertility, which really relies on a whole lot of things, which I'm going to now take you through what we need to do. It is said, or was said, that 30% of infertility was unexplained. I think it's way, way less than that if we actually look at our patients, both of them, carefully with history and examination and directed tests, and you will probably reduce that to about 3%. Let me take you through female age first. Now, in the old trials, some of the women recruited were as old as 42. That is not unexplained infertility. We know about oocyte aneuploidy and female ageing. 41, it's not unexplained. 40, it's not unexplained. 39, it's not unexplained. And I would put it to you that the cut-off where you start to see oocyte aneuploidy significantly constraining fertility is probably 35. So unexplained infertility has to, by definition, be a woman who is less than 35. I put that to you. Now, let's look at the male. Now, what do we know about the male, the effect of male age on fertility? We know that if the woman is over 35, and this is beautiful work that's really done many years ago in Europe, that if the woman is over 35 and the male is five years older than her, her chance of natural conception is reduced by a further 30%. So I put it to you that, therefore, the male age is relevant. And if she's 35 and has a partner who's 35 years older than her or more, it's not unexplained infertility. It's related to couple age. Now, we're going to... So that's age. Now, my colleagues are going to take you through a number of treatment interventions other than IVF, which we can do with good effect if we actually make the diagnosis and don't put them into the category of unexplained infertility. You will remember from the old trials that mild or moderate or mild or minimal endometriosis was often included, as was mild male factor or seminal fluid abnormalities. These were really multifactorial infertility, and I think that's the take-home message, that much of what we call unexplained is multifactorial. You have two minor components that act to reduce natural fecundability. So I now just want to take you through some of the diagnoses that contribute to infertility that we may not, in our routine laparoscopy and workup, we may not pick up and have previously been called unexplained infertility. For instance, we know that adenomyosis is probably one of the mechanisms by which endometriosis contributes to infertility. Chronic endometritis is now emerging as an operative factor in infertility, and that will not be diagnosed easily. Mild or minimal endometriosis, my colleagues will cover. The mid-cycle scan will lead you to the thin endometrium, which may be due to unexpected adhesive disease, but also a thin endometrium, which we know has a very adverse prognostic factor, may be due to long-term progestin contraception. We are starting to see this emerge. Secondary infertility after a caesarean section may be due to an isthma seal, and we won't recognise that unless we do mid-cycle scans. That's the female. Let's look at the male. We know now that seminal fluid analysis is not a good predictor of male fertility, and there is now evidence from Ranjith Ramasamy's work that we are missing clinical varicoceles because we failed to examine the male partner. My colleagues will talk more about that. We may miss DNA fragmentation, which again may contribute via the basic seminal fluid analysis. Now, most of these diagnoses can be made or sorted out or excluded within one or two months of your detailed assessment of both partners by history and examination. So it's not straight to IVF, ladies and gentlemen. It's just a little digression, a little lay-by, where you actually assess the patient thoroughly. She did not need a tie for that rebuttal. LAUGHTER Prasad. Thank you. Well, following from what Professor Hart has said, I'm going to show that IVF should be a go-to option because of its effectiveness, cost-effectiveness and safety. Now, let me first talk about the effectiveness, and as this is an interaction session, I would like to ask the audience, please, by show of hands, to show me how many of you would accept a medical treatment or buy a new incubator if it had a 94% chance of failure? Well, let the moderator please note that no hands have been raised. Thank you very much. Yet, the chance of live birth in Australian population following IUI is 6%, where, after IVF, the live birth is 40%. Almost seven times more. Now, why would we subject our patients to something we ourselves would not choose? Similarly, findings were reported from international studies that the hazard ratio of 1.25 favouring immediate IVF, and I will talk later about why it is important from a safety perspective. Cost-effectiveness. And I quote ESHRE guidelines. The costs, treatment options have not been subject to robust evaluations. Now, again, I would like to ask the audience, this time it's an easy question, how many of you would accept as standard an ongoing pregnancy rate of at least 38% for an average IVF cycle? Yeah, hands up. All right, I've got three-quarters of the room. OK. Well, I could really rest my case now, as we have good evidence that if a clinic has got an ongoing pregnancy rate of 38% or higher with IVF with single embryo transfer, then it is more effective, more cost-effective, and should be a treatment of choice. And that evidence comes from the authors that are sitting in this room. Again, what would the patients do? If the patients are paying for the treatment, would they do IUI? Most of them would actually go straight to IVF. And we also have very nice guidelines which advise against IUI based on cost-effectiveness. Another factor to mention briefly is the multiple births, which cost five to 20 times more than singleton. The neonatal cost of a twin birth costs about five times more than singletons, and pregnancy with delivery of triplets or more costs nearly 20 times. Now, the costs that I'm going to quote are in American dollars and from some time ago, from Fertility and Sterility. However, the total adjusted all healthcare costs for a single-dom delivery is about US$21,000, US$105,000 for twins, and US$400,000 for triplets and more. Then the very, very important is the psychological cost of the high risk of failure with IUI. Now, it is well established that infertility has a psychological impact on our patients. Studies have shown that prolonged time to conception extends stress, anxiety, and depression, and sexual functioning is significantly negatively impacted. Literature shows that 56% of women and 32% of men undergoing fertility treatment report significant symptoms of depression, and 76% of women and 61% of men report significant symptoms of anxiety. Shockingly, it is reported that 9.4% of women reported having suicidal thoughts or attempts. The longer the treatment takes, the more our patients display symptoms of distress, depression, and anxiety. Safety. Again, ESHRE guideline says the safety of treatment options have not been subjected to robust evaluation. But let me talk you through it. In our Australian expert hands, IVF is safe, with the risk of complications of ectopic being about 1 in 1,500 and other risks 1 in 3,000. However, let's think for a moment on impact of multiple births. A multiple pregnancy has significant psychological, physical, social, and financial consequences, which I can go further into details if required. I just want to mention that the stillbirth rate increases from under 1% for singleton pregnancies to 4.5% for twins and 8.3% for higher-order multiples, and that multiple pregnancies have potential long-term adverse health outcomes for the offspring, such as the increased risk of health issues through their life, increased learning difficulties, language delay, and attention and behavior problems. The lifelong disability is over 25% for babies weighing less than 1 kilogram at delivery. And please note that the quoted multiple pregnancy rates with IUI can reach up to 33%, although in expert hands it's usually around 15%, which is significantly higher than single embryo transfer. In conclusion, from the mother and child safety perspective, for the reason of medical efficacy and cost effectiveness, we have reasons to believe you should go straight to IVF. We're going to be doing these debates more often from Australia. This is a great panel. One side, please. Unexplained infertility. My colleagues were comparing IUI ovulation induction with IVF, but there are other ways of achieving pregnancies with unexplained fertility. I'm going to take the patient's perspective a little bit here. It's all about shared decision-making, so the patient needs to be involved in the decision-making. And it's quite clear from all the data that many patients with unexplained infertility will fall pregnant naturally by themselves even if you do nothing. So sometimes there's definitely a place in doing nothing, and the patient needs to be aware of that. So it's all about informed consent. How do we inform the patient? So we've got to make a proper diagnosis, as my colleague Dr. Boothright has already mentioned, and just to jump into IVF because it's cost-effective is not doing our patients a justice. The prognosis is really, really important, and even after 20 years of doing this, it's all about the duration of infertility, the age of the patient, and discussing that prognosis with the patient. We all know that patients who have been trying for longer and who are older do have a worse prognosis, and maybe they do need to look at treatment quicker, but there are many patients that we see that have a good prognosis, and just explaining that to them is all they need to achieve a pregnancy naturally. And then we're going to talk about other options. It's wrong not to offer those to patients, and my colleague Dr. Quick will talk about that in a moment. Look, we've all had patients that have been scarred by IVF who've spent a lot of money on IVF, did not fall pregnant, and I think the fact that they weren't informed properly, that the diagnosis wasn't made properly, is very frustrating to them. So to just jump into IVF again is not doing the patients a justice. And look, there are negatives to IVF. There's not just the cost to the patient, the cost to society. As taxpayers, we all pay for IVF. It's funded here, or sponsored to some degree, and it's also the family and everyone else that's involved in paying for this. So this is not a treatment that is without cost. There are some harms. We know that ovarian hyperstimulation syndrome still exists, even though it's much less than it used to be. There's a risk of infection and bleeding from the procedures. And we can look at the baby. The data still suggests that babies born from IVF are smaller and they're born earlier, and monozygotic twinning is more common with IVF, so these are high-risk pregnancies, and all this may have an impact on the long-term health of the babies somewhere down the track at the moment. That is important to still look out for. But I come back to the emotional toll. Our colleagues were saying that finishing infertility quicker helps to kind of reduce the emotional toll, but the procedure itself does have its own toll if it doesn't work, and so we've got to prepare patients, have them informed. But at the end of the day, it's all about patient choice. How can a patient make a choice if we don't make a proper diagnosis, give them a prognosis and offer them some other choices that exist? And running the anchor leg of the race for the pro side. IVF in couples with unexplained infertility is the best tool we have in our reproductive medicine toolkit for multiple reasons. Professor Hart has clarified the definition of unexplained infertility. As a reflection of the degree of investigation we've undertaken. He's explained that IVF is often importantly diagnostic as well as therapeutic, both demonstrating and overcoming barriers to natural conception. Dr Stankiewicz has convinced us that IVF is efficient, safe and cost-effective. My goal is to show you that IVF is the correct therapy to meet the immediate and big picture family planning goals for our patients with unexplained infertility. More than 80% of couples with defined unexplained infertility who attempt IVF treatment will have a baby. In Australia, ANZSREI data shows us that the average age of the female patients who present with primary unexplained infertility is over 35 years. And in fact the average is 38 years. We're all aware that the average age of first maternity in Australia has progressively become later over the past two decades. Currently it stands in the mothers and babies report at 32 years. If the average age of first maternity is 32 years, this means that at least 50% of women attempting their first pregnancy are over 32 years. Research I conducted in Melbourne University with my student Eugenie Pryor asking university students of their family planning intentions and aspirations demonstrated that most people, male and female, want to be parents and most want to have more than one child. However, in Australia, our most recent survey shows that births are at an all-time low, below replacement rate and falling, with an ever greater proportion of our population being unable to have the number of children they aspire to and an ever growing proportion seeking assisted reproductive care. Fertility declines with age. Factors include egg quality concerns, sperm quality concerns and the accumulation of pathologies over time. Adenomyosis, fibroids, endometriosis are concerns that no person is born with. They exist on a spectrum and progress over time and may be contributing factors for unexplained infertility. Our patients, when we meet them, are the best IVF candidates that they will ever be. They are the youngest they will ever be and they have the best ovarian reserve they will ever have. They will generate more euploid embryos now than they will in years to come. The sooner we get our patients pregnant, the sooner they will give birth. It takes nine months to have a baby, 12 months potentially to breastfeed and wean and of course most patients will need time to care for a young infant and recover prior to attempting another pregnancy. IVF and embryo banking may represent not only their best chance of conception with reduced time to pregnancy but also an opportunity for embryo banking to improve their cumulative live birth rate potential over time. By the time our 38-year-old patient returns to try to conceive for a second child, she will undoubtedly be aged over 40. Her chance of live birth per cycle initiated at IVF at this stage has reduced phenomenally. The ANZSREI dataset from our most recent report quotes that statistic to be 5%. Her chance of conception with an embryo frozen at 38 years, conversely, is one in three to one in four. There is no room for doubt that IVF gives couples with unexplained infertility not only the most effective treatment we have to help them have a baby, but their best opportunity to have a family. Last but certainly not least, Dr. Quick, to round out the con sides arguments before we open up for rebuttal. And I'll make a small plea that if you have questions that you'd like to pose directly to the panel, prepare them and we'll make sure we get to them from the audience shortly. Thank you. So, whilst we have heard that we may be bad doctors because we're delaying our patients' time to pregnancy, I would perhaps put it to you that unexplained infertility is a diagnosis which is made based on exclusion. So perhaps you are the bad doctors because you haven't looked hard enough for the cause of the unexplained infertility. So, in terms of the tests that we all would do, I think, we would all ensure that the woman has an ovarian reserve. We would all ensure that she has no structural anomaly inside the uterus. We would all ensure that her tubes are patent. We would all ensure that she has regular cycles. We would ensure that he has a normal semen analysis. I think these are tests that we would all do when trying to evaluate a couple for fertility who are struggling to conceive. And therefore, the chance of them getting pregnant naturally, it's never going to be zero. And one option therefore, instead of running straight to IVF, would be to say, OK, continue timed intercourse because the chance of you conceiving naturally is not actually zero and this would be the most natural way to conceive, the cheapest way to conceive, the least interventional way to conceive. And whether that be with cycle tracking to ensure appropriate timed intercourse, whether that be with cycle tracking to ensure adequate luteal phase support. When you clear the fallopian tubes, we know that there are studies showing an improvement in natural conception. Lipidol or oil-based tubal flushing techniques may also help couples to conceive naturally. And then you don't have this multiple pregnancy rate that IVF has. You don't have the cost that you incur with IVF, not just for the couple but to Australian society because IVF is subsidised in this country. You don't have the risks that the woman goes through to undergo IVF treatment. You don't have the risks that the baby takes on being conceived via IVF. And so conceiving naturally, because it's not going to be zero, is definitely an option for these couples. In terms of further tests or further investigations that you could do, some people would argue, yes, we haven't looked hard enough for the reason for infertility, therefore we know that ultrasound is notoriously bad at picking up superficial endometriosis. We know that ultrasound cannot pick up subtle changes in the endometrium, as Dr Boothroyd referred to chronic endometritis, for example. So these patients perhaps should undergo a hysteroscopy to see if there is an endometrial issue. Perhaps these patients should undergo a laparoscopy to see if there is superficial endometriosis. And there are meta-analyses showing that resecting or treating superficial endometriosis may actually help these couples conceive naturally down the track and then therefore they avoid having more interventional treatment in order to conceive. There is also intrauterine insemination with or without ovarian stimulation, which may improve their chances of conceiving naturally. And that again would be less invasive, less intervention and cheaper for the patient. And we know that therefore there are a lot of other treatment options available to help these couples to conceive. And if it's less invasive, it's more natural, it's cheaper, that ends up being better for the patient. Psychologically as well, which the other side have brought up, even with Dr Stankiewicz's 38% ongoing pregnancy rate, that also means that 62% of his patients are not going to be pregnant. The psychological impact of that cannot be underestimated because for a lot of patients, IVF is your last resort. And when you don't get pregnant with IVF, that creates an issue too for them. Embryo banking, which was also brought up, what happens when you create surplus embryos and what's the psychological impact of having to deal with embryos that you are then not going to use in the future? So therefore for those reasons we feel that IVF is not your first line treatment for couples who are diagnosed with unexplained infertility. There are many other ways to help these couples to conceive. We just have a multitude of things to unpack. And I want to start off by opening up an opportunity for rebuttal. I saw both sides of the panel here taking diligent notes. I think all of us have a full page worth of things that kind of stood out to us. Since the pro side had an opportunity to begin, I'm actually going to start with the con side and allow the con side to answer specific points made by the pro side and provide just a little bit more detail and clarity for why they think IVF is not the way forward. My learned first speaker, wearing his tie of course, indicated that it was all about laparoscopy and IUI, and it's way more than that. I just want to highlight to you the paper by Dressler in 2017 in the New England Journal of Medicine, a randomised controlled trial of what would be unexplained infertility according to the definition I put out, the less than 35 ovulatory normal semen analysis. And the intervention was an HSG with either oil-based contrast or water-based contrast. And over the six months, there was clear separation, and this is an effective treatment for unexplained infertility or mild or minimal endometriosis, however it might work. And there's probably separation out to three years. So as a single intervention, as an alternative to IVF, the use of oil-based contrast is an option. So it's not just about laparoscopy and IUI. I guess the other thing the second speaker did allude to, fairly abysmal success rates with IUI being 6%. That is a problem, and I would like to allude to a very good pragmatic trial conducted by Cindy Farquhar and Emily Lu and their co-workers in New Zealand that really swung the meta-analysis for the use of clomiphene and IUI to clinical efficacy. And they reported a 33% chance of live birth in their IUI and clomiphene arm. I'm going across to Auckland to see what the magic is in that city. What are they doing? The third speaker did allude to the problem of declining fertility, a global problem, and Australia is not alone. We have solved the problem to date, which we've had for 40 years, with immigration. But Georgina Chambers' work shows beautifully that IVF is not the answer to the falling fertility rates. It is a way more complex social problem and is probably outside the scope of today's discussion. So those are my three rebuttals to our wonderful team. Thank you very much. So... You can't bury them. We'll give them an opportunity. Thank you for the opportunity. So I'd like to address some of the points that my learned debaters on the opposition raised. The first speaker really suggested quite a few things that we probably omitted, like endometritis, failing to examine the male. I think things like that... I think, at a good history, that is essential what we do as part of our investigation. We're looking for a history of cesarean section, complications subsequent to that. We're doing a detailed scan, and that will exclude the fact that she's got a poor endometrium development, she's got a cesarean scar niche. A good history of a male will allude to the fact that he has some metabolic disorder, degree of hypogonadism. So we're not delaying anything by these appropriate investigations. Adenomyosis will be raised. I talked about a detailed gynaecological examination. So I honestly think that a very... As my opening line was, a detailed gynaecological scan, obviously with a very good history taken, is essential. We're not delaying her opportunity to go straight to IVF if we've addressed all these factors. The second speaker talked about shared decision-making, and we'd all completely agree with that. But we have to be honest and open about the success, which my second speaker talked about, the success of the treatment we're offering. And one thing we should sort of dwell on is it's all... It's a fundamental description of the success of treatment is probably all about prognostic models, and that who not model, that's the original model about the success of conception, is really... Everything flows on from that, which basically talks about a good prognosis patient. 30% chance of live birth after a year. That's what they talk about, a good prognosis patient. Perhaps the rest of the world is different to your average Australian patient, but if we talked about that being a good prognosis, you've got a one in three chance of being pregnant by a year. I think most of our patients would throttle us. So that is what all the models are sort of based on, that being a good prognosis patient. So I completely agree with the second speaker that we do have a shared decision. We have to be honest with our patients about the success. We have to be honest about giving them the prognosis of any treatment that we offer. But really, as my third speaker was talking about, it's about giving the patient the opportunity to have a family, minimal career disruption, minimal life disruption. We have to be honest and talk about the whole picture. They're focused on the first child because really they can't think beyond that. We're talking about giving them the family that they need. The third speaker spoke very eloquently about the risks associated with the treatment we offer. I believe we offer a very safe service with our IVF, particularly in Australia, with our 2% twin pregnancy rate. We talk about the higher risk of these pregnancies, but they perhaps don't relate to the treatment we're offering. Perhaps, unfortunately, is the patient, if she's got polycystic ovary syndrome, if she's more likely to have diabetes, premature delivery, preeclampsia. So I think often the risks associated with IVF and potentially the risks associated to the child born from IVF perhaps don't relate to the treatment of IVF per se. It may well be the woman and perhaps her partner, their underlying medical condition, which lead those risks. So I strongly would encourage you to believe that you take a very good history from your patient, you do a thorough investigation, as I've alluded to, looking for any signs of ovulatory disorder, any gynaecological disorder by a detailed scan, checking tubal patency and a detailed history and the similarities from the man, and then you'll find you're probably going straight to IVF. APPLAUSE I'd like to talk a bit about the embryo banking and having been in this field for a long time, as a word of caution, we're setting a lot of expectations. I remember going to an ASRM meeting probably 10 years ago where they had this headline, all your embryos in the freezer, your whole family in the freezer, basically expecting that if you get four or five embryos frozen that you'll end up with a family at the end. We all know that for the patient, they're not a percentage, it's either zero or 100%. And if all the embryos don't work, they don't have a family at the end, you know, it didn't work for them and their expectations haven't been met. And the way we talk about the percentages and that we can solve the patient's problems, that we can make families, it doesn't always happen. So the expectations our position is setting here, we're not always able to meet and so we're going to end up with very unhappy patients. So this is just a warning to everyone that we need to tell people that this doesn't always work and sometimes they'll end up with no success at all. And from that point of view, I think the way it's presented is way too simplistic and we've got to go back to looking at the other options and not promising things we can't always deliver. So just taking into account all our esteemed interlocutors have said, we don't necessarily disagree with the amount of investigations that they described because nowhere in our argument we said that as soon as the patient registers with the receptionist, they will direct it to an IVF lab. I think to imply so, we'd be very rich indeed. Maybe there are some clinics that are so efficient. I don't know how it works overseas, but certainly not in Australia. The other point that was made about the cost of IVF and our, again, esteemed interlocutors are very well aware from the studies done here in Australia that actually every baby that we have to conceive through IVF and create and lives is actually more than 10 to 100 times return on investment because we are creating future taxpayers. We are creating people that will repay the IVF treatment costs over and over and over again. So I'll put to you, Rob, that if you are saying that we can't do IVF because it costs money, you are robbing future treasurers of a huge amount of dollars. I hope the American audience is listening. In America, we call embryos unborn children in freezers in certain parts and here they're unborn taxpayers. Con side, final opportunity for rebuttal before some audience questions and one more word from the pro side. Well, actually, Dr Stankiewicz was very happy to hear that you're not going to send your patients straight to the IVF lab because we've managed to convince you that that's not the right thing to do. I clearly have forgotten how to debate because I did all my rebuttals at the end of my presentation but essentially I'll recap because when we're talking about IVF, as we're saying, the chance of pregnancy is not going to be 100% and so there is a psychological impact to IVF not working. There is a psychological impact to banking embryos and creating surplus embryos that eventually may not be used and they were my main rebuttal points in terms of why IVF was not the first-line treatment. Thank you. So we've heard from the opposition some very valid points of how our patients can be psychologically impacted when fertility treatment is unsuccessful. I will again remind you that IVF is the most successful fertility treatment we have in our treatment armoury. We are most likely to help our patients have a baby with IVF. The cumulative pregnancy rates for IVF have started back in the late 70s and early 80s in single-digit percentages. We now, with a best prognosis candidate, have at least a one-in-two chance of that patient having a baby per embryo transfer and in our patients with unexplained infertility, the vast majority of our patients will have success. We also heard from the negative team about the significant chance of pregnancy in patients with expectant management. You're right, there's not a 0% chance of natural conception in patients who have unexplained infertility, but there is a not very good chance. We know from data that we've had for a really long time, going back as far as the Hutterite data, to today's non-contradictory models, which tell us that a couple's chance of conception per month in best prognosis candidates is one in five. If they've been trying for six months, it's one in ten. If they've been trying for 12 months, it's only 5%, and if they've been trying for 24 months, it's less than 1%. So it may not be zero, but it isn't very good. In terms of our team reminding us of the extended ICMART definition of unexplained infertility, we don't argue. When we say someone has unexplained infertility, we make the assumption that they have been comprehensively diagnosed by a robust reproductive endocrinologist, as everyone in this room is. And I would say one closing rebuttal. IUI success rates have been the same for the last 50 years, whereas IVF success rates continue to improve. Why would you offer your patient a treatment from 50 years ago when you can offer them one from today? Thank you. APPLAUSE I'm going to take a personal privilege and ask the first question, in hoping that the microphone makes its way to the second question in the audience. My colleagues on the pro side have said IVF, IVF, IVF. Can you be a little bit more specific about what kind of IVF? Do you mean IVF with ICSI? Do you mean IVF, ICSI, and PGT? Be a little bit more deliberate for us and tell us exactly how the patient with unexplained infertility should receive IVF. As I said in my statement, I think it's a diagnostic evaluation. I think there is an argument to consider ICSI, but I think ICSI does have some negative consequences for children born. I think perhaps going straight to ICSI is too much. I think going straight to PGTA perhaps is too much, unless there is something in their history which should indicate that. But we're talking about unexplained infertility. So I believe a standard IVF cycle, looking at the opportunity to assess embryonic development, is the way to go. I do not think you should be going straight to ICSI. I think the principle of first do no harm is probably a safe approach. I don't know whether my colleagues have some other comments, but I think that would be the first approach rather than going all guns blazing. I can understand, though, in different settings in the world, there may have... We're very fortunate in Australia, we're very well supported from the government support for IVF, but I think the imperatives in different countries may be different. But I think that approach would be the right one first. We'll start with a question from the audience. And if you could introduce yourself and have the question allowed for our members in the audience who are not here. It's Louise Hull here from Adelaide. The question I would like to put to both the pro and con team is that Geeta Mishra from the University of Queensland showed that if you had diagnosed endometriosis before IVF, you were more likely to have a pregnancy and much less likely to have high-order IVF cycles. Given that we now have really good non-invasive diagnostics, we're actually... A lot of the time we can pick up superficial or stage 2 endometriosis if you get the right scan. We're going to do IVF better if we know about it. Can you comment on that impacting even the diagnosis of unexplained infertility? Thanks. I'd love to take that. Can I go first, Roger? LAUGHTER Please do. Look, I'd love to take that question. It's a really good question. And, of course, this is not unexplained infertility, so this is outside the scope here. And I think, really, what we're seeing now, in contrast to where we were at the time of the Markku study, which was all... And the Tulandy study on endometrioma excision, we now see that that is actually damaging to fertility, particularly where there is ovarian endometriosis, and that we compromise their ovarian reserve by doing this surgery before we preserve their fertility, be it oocyte cryopreservation or embryo cryopreservation. So I think it's a bit outside the scope of this talk, but I think the swing of the data now is that we should be doing fertility preservation before we do surgery for deeply infiltrated ovarian endometriosis. And that would fit with Gita's findings. A brief response. Thanks very much, Louise. Yeah, we're talking about unexplained infertility here, and my opening line was we need a history, but a detailed gynaecological ultrasound. I think it's important it's a really good ultrasound to exclude that, because the evidence around very minor endometriosis is not there. I agree with significant endometriosis, but that's not the subject of this discussion. But I do believe with very minimal endometriosis there is really no evidence for that. Janelle MacDonald from Sydney. I'm going to play devil's advocate here. So everyone is probably aware of the recent government inquiry about obstetric violence. I'm a little concerned that if we are perceived to be encouraging women to IVF first, are we guilty as a profession of performing fertility violence? That's just digressing a little bit, just thinking about how the consumers may perceive this. I think our patients want to have a baby, and that's why they come to see us, and that's what we help them to do through IVF. I'm not sure the microphone's working. And just introduce yourself. I'm from Sydney, Australia. Can I disagree with you, Roger, about that question about minimal and mild endometriosis? I'm 68, so I'm old enough to have read a whole lot of papers in the past that are probably seen as relics. But Mark Khoo published an unusual study, because it was actually an RCT. Well, sorry, not an RCT. It was a study whereby... Well, it was an RCT, and it was randomised really well. It was done in Canada, and there were about 350 subjects, and they were identified to have stage 1 or stage 2 endometriosis at laparoscopy. And the interesting thing is it was seen as an intervention which didn't greatly increase the chance of conception, but it doubled the monthly chance of conception. So there was clearly a difference between those patients who didn't have endometriosis and those that had stage 1 and stage 2 endometriosis. So the intervention did actually result in an improvement. One of the quotes was, well, I heard since then, well, it didn't make much difference. But when you realise that infertility is multifactorial, there were probably other factors involved as well. So any increase like that in stage 1 and stage 2 endometriosis sufferers was clearly beneficial for them. So I wouldn't disagree with you completely, but I do think you've got to take it on board that there is some evidence that surgical intervention can help. And certainly in those patients whereby the financial costs of IVF are still quite, even in Australia, astronomical. Many patients can get this through the public sector or the private sector treatment of their endometriosis laparoscopically very cheaply or at no cost. Thanks, Dr Persson. So you're right that there was also a counter-randomised controlled trial by the Grupo Italiano which was a counter to that. And actually did not show any benefit. But I believe the Marcu study demonstrated an excess of conception and with treatment of minima and endometriosis of about 4% per month for a few months. So absolutely, that shared decision-making. Personally, I wouldn't like a laparoscopy to give me an extra 4% chance of a natural conception for four months, which I think the data was. So basically, the basis to my statement that I said without going into great detail was a review article published by Samy Glarner recently in Reproductive Biology and Endocrinology. And their conclusions were what I basically said, that from looking at all the data, there is no real evidence of intervention for minor endometriosis. We're not talking about pain or significant diagnosed endometriosis on the outcomes of IVF, ovarian reserve, egg quality, embryo development, and euploidy rate. So that was the basis of my... I hate to disagree... I hate to agree with my opponents in a debate, but I'm going to... But there is actually a new network analysis by Rui Wang and some serious heavyweights in evidence-based medicine that pulls together the surgical studies. And the thing that made the most difference to this of mild and minimal endometriosis from a fertility point of view, not pain, is the use of oil-based uterine contrast. And I commend that paper to you, which fits with exactly what Roger is saying. Hi, my name's Lucy Prentice.  I work in Auckland. And I just wanted to point out the New Zealand perspective a little bit. Where we come from a country with very limited public funding for IVF. I'm currently running an RCT with Cindy Farquad directly looking at IVF versus IUI for unexplained infertility. And I'd just like to point out that both the ASRM and ESHRE guidelines, which are the most recent ones, both suggest that IUI should be a first-line treatment with oral ovarian stimulation. We have no evidence that IVF is superior based on an IPD meta-analysis published very recently and also a Cochrane review. And although we would love to be able to complete the family that our patients want from IVF and embryo banking, that option is really not available to a lot of people in New Zealand because of prohibitive costs. We know that IUI with ovarian stimulation is a very effective treatment for people with poor prognosis and unexplained infertility. And I also would just like to add that there's not a cost-effectiveness analysis that shows an improvement in cost-effectiveness for IVF. There's also never been a study looking at treatment tolerability between the two, so I don't think that you can say that IVF is a treatment that people prefer over IUI. So I may turn around and shoot myself in the foot based on our results that will be coming out next year, but I think at the moment I don't think you can say that IVF is better than IUI with ovarian stimulation for unexplained. We have time for two more questions from the audience, and we have two hands in the back. Now we can. It's the light green. OK. Hossam Zini from Melbourne. Thank you very much for the debate. It's very interesting. The problem is that all of the studies that have been done about comparing IUI to IVF, they are not head-to-head studies. The designs are different. They are having, like, algorithmic approach. For example, they compare three or four or five cycles of IUI to one cycle of IVF. But about 10 years ago, our group at the Royal Women's Hospital, we have done a study, a randomized control study, to compare IUI to IVF head-to-head, and we randomized the patients at the time of the trigger who only developed, so we did a low stimulation to get two to three follicles only, and that's why it was so hard to recruit lots of patients. So the criticism that was given to the study that it's a small sample size, but we end up with having IVF as a cost-effective treatment. Our IVF group had a live birth rate about 38%, and on the IUI, 12%. And with our cost calculations, we find out that the IVF is much more cost-effective than the IUI. But I believe that we all now believe in individualized kind of treatment, so patients probably who are younger than 34 years old probably wouldn't go straight to IVF. Maybe I'll do a laparoscopy and a histroscopy first, okay, and we may give them a chance to achieve a natural conception in the next three months or so. Patients who are older than 35, 37 years old probably will benefit straight from IVF. But again, in day-to-day life cases, we will not force the patient to go straight to IVF. I will talk to her and I'll tell her, these are your options, expectant treatment. This is the percentage that you would expect. IUI, this is what you expect. IUI with ovulation induction, this is what you expect. IVF, this is what you expect. And then she will discuss that with her partner and come back to me and tell me what she wants to do. Thanks. I saw a hand show up right next to you, so I'll add one more question given our time limitation. Thanks so much, Kate Stone-Mellon. I'd like to ask our panel to take themselves out of their role playing and put themselves in another role where they were the head of a very, very well-funded public service, and I'd like to ask the two sides what they really think about what they would do with a patient at the age of 35 with 12 months of unexplained infertility. Well, can I say that? Because that's my role in a different hat. LAUGHTER So, yeah, I run the state facility service in Western Australia. We looked at the data, because obviously that's what we're doing, IUI, IVF, and unfortunately we stopped doing IUI treatment. The success rate was so low. So we do go straight to IVF with unexplained infertility. Disappointing, as I'm sure you hear that, Kate, that we do. We looked at the data. Yeah, I think that I would still offer the patients the options, because some people don't want to do IVF. Even though it's completely free, they may not still want to do the injections and the procedure and take on the risks of the actual egg collection procedure. I don't know, religious issues with creating embryos. Yeah, I would still give patients the option. We have time for one more question in the back. We'll take the other ones offline afterwards. We'll get you a microphone just to make sure our listeners afterwards can listen. Following on from the New Zealand experience, which I've experienced... Hello? Yeah. From the New Zealand experience, and having worked here extensively and in New Zealand, you're not comparing apples with apples, Claire. That unexplained couple in New Zealand will wait five years to get funding and currently perhaps another two years to get any treatment. That's then an apples group compared to the pilot group who may, in fact, walk past the hospital and get treatment. The other thing about this, I think, that we need to forget, or don't forget, is the ethics of things here, two of which is that the whole understanding of unexplained infertility needs research and thinking. And if it wasn't for that understanding of what is the natural history of normal and then the understanding of pathology, we wouldn't do a lot of things in medicine. So if we have got a subgroup here that's unexplained, it's not just to the patient, we have a responsibility to future patients and ourselves to be honest and do research and learn about these factors. Now, it doesn't answer the debate, but it is something that's what drives the investigation and management of unexplained delay. And, for example, at the moment, there's quite a discussion about two issues of ethics, one about the involuntary childlessness of people that don't get to see us but don't have those children that they wanted to have because they didn't want to undergo treatment, or it was the involuntary childlessness of a second or subsequent child. And that's quite a big research issue in Europe, I realise, at the moment. And the final thing is about the information giving. The British case Montgomery 2015 has changed consent substantially, for those of you from England, that all information given to patients must include and document the discussion about expectant management versus all the different types of treatment, for and against and risks. And we're not currently doing that in IVF in this area, but if you read about what's happened in England, it's transformed consent in surgery. And I think a lot of our decision-making isn't in that way. So there are a couple of ethical principles to think about. Wonderful questions from the audience. Since we're coming up at the end of our time, we typically end the debate with closing remarks, but we'll forego that for this debate. And I'd actually like to just poll the audience. After hearing both the pro and the con side's arguments, by a show of hands, who in the audience believes that for the patient with unexplained infertility, as defined and detailed here broadly, should we be beginning with IVF? Should we be going straight to IVF? So by a show of hands. And I would say probably 50% of the room raised their hand. And those who think we should not be going straight to IVF? It feels like a little bit more. 40-60, now that I saw the other hands. Well, I'm going to call this a hung jury. I don't know that we have a definitive answer. Please join me in a round of applause for our panelists. In America, we would call that election interference. I wanted to thank our panelists, our live audience, and the listeners of the podcast. On behalf of Fertility and Sterility, thank you for the invitation to be here at your meeting and hosting this debate live from the Australian New Zealand Society for Reproductive Endocrinology meeting in Sydney, Australia. Thank you. This concludes our episode of Fertility and Sterility On Air, brought to you by the Fertility and Sterility family of journals in conjunction with the American Society for Reproductive Medicine. This podcast was developed by Fertility and Sterility and the American Society for Reproductive Medicine as an educational resource and service to its members and other practicing clinicians. While the podcast reflects the views of the authors and the hosts, it is not intended to be the only approved standard of living or to direct an exclusive course of treatment. The opinions expressed are those of the discussants and do not reflect Fertility and Sterility or the American Society for Reproductive Medicine.    

In dieser Episode geht es um das Thema "Kinderwunsch-" oder auch "Fertility Yoga". Du erfährst, wie diese spezielle Yoga-Praxis Frauen auf ihrem Weg zum Wunschkind unterstützen kann und was sie von anderen Yoga-Stilen unterscheidet. Unsere Expertin, Elisabeth Kippenberg, ist Yoga-Lehrerin mit eigenem Yoga-Studio speziell für Frauen in Berlin, Fachberaterin für Ernährung und Hormone sowie selbst zweifache Mama. Sie teilt ihre persönlichen Erfahrungen und gibt wertvolle Tipps, wie Kinderwunsch-Yoga auf natürliche Weise Körper und Geist in Einklang bringen kann. Schön, dass du dabei bist. Wir klären heute folgende Fragen:Was genau ist Kinderwunsch- oder Fertility Yoga?Wie unterscheidet sich diese Yoga-Praxis von anderen Stilen?Wer profitiert besonders von Kinderwunsch-Yoga?Gibt es wissenschaftliche Belege für die Wirksamkeit?Wann sollte man besser kein Kinderwunsch-Yoga üben?Muss man Kinderwunsch-Yoga täglich praktizieren?Wie kann man Kinderwunsch-Yoga am besten lernen?Kennst du schon unsere keleya Mama App? Hier findest du unsere Kurse zur Rückbildung, zum Stillen sowie zur Beikosteinführung, zum Babyschlaf, Mindfulness sowie Vieles mehr. Zudem haben wir für dich interessante Artikel, Videos und Audios speziell für das erste Baby-Lebensjahr zusammengestellt. Hier geht's zur Mama-App: [https://keleya.de/mama-app/]Und für die aufregenden Monate vor der Geburt schau doch mal in unsere Schwangerschafts-App. Interessante Informationen, hilfreiche Praxistipps und wertvolle Anregungen warten auf dich. Hier findest du auch unseren digitalen Geburtsvorbereitungskurs. Dieser Online-Kurs wird von vielen Kranken- und Gesundheitskassen gefördert. Hier geht's zur keleya Schwangerschafts-App: [https://keleya.de/schwangerschafts-app/]Vielen Dank an Elisabeth Kippenberg. Auf ihrer Webpage findest du mehr zu ihren Angeboten: [https://youglowyoga.berlin/]. Bei Instagram findest du sie unter: [@youglowyoga]. Links zu den wissenschaftlichen Studien aus der Episode zum Thema:Domar, A. D. (1996). Stress and infertility in women: Is there a relationship? Psychotherapy in Practice, 2(2), 17-27. Valoriani, V., et al. (2014). Hatha-yoga as a psychological adjuvant for women undergoing IVF: A pilot study. European Journal of Obstetrics & Gynecology and Reproductive Biology 176, 158-62. Danke für dein Interesse und Vertrauen. Von Herzen,Dein keleya Team… folge uns gern bei Instagram [@keleya.app] und Facebook [@getkeleya]. Hosted on Acast. See acast.com/privacy for more information.

Originally published March 12, 2024Learn how your vaginal flora and gut microbiome contribute to your reproductive health. Dr. Caroline Mitchell shares her expertise and research on this important but overlooked topic.Episode SummaryIn this episode, we take an in-depth look at the delicate balance of the vaginal microbiome. Dr. Caroline Mitchell, distinguished reproductive health researcher and faculty member at the Vincent Center for Reproductive Biology at Massachusetts General Hospital, shares her profound insight on why a healthy vaginal microbiome is crucial in women's health. With a background in Women's Studies at Harvard College and groundbreaking research funded by prestigious organizations, Dr. Mitchell brings a wealth of knowledge and experience to the discussion. She explains the complexities of understanding vaginal flora, the challenges posed by bacterial vaginosis (BV), and the intriguing connections between gut health and vaginal health. Listen to learn about some of the most significant yet overlooked aspects of women's reproductive health. We discuss how to balance the vaginal microbiome, what to do about chronic bacterial vaginosis, use cases for a vaginal microbiome transplant, and what innovative treatments are emerging in women's health. Key Discussion PointsWhy a healthy vaginal microbiome is crucial for women's overall health and how imbalances can lead to conditions such as bacterial vaginosis (BV).The difficulties of limited funding and the complexity of research regarding the vaginal microbiome.Symptoms of BV, its limited treatment options, and common misdiagnoses such as vulvodynia.Yeast infection vs. BV vs. UTI symptoms.The impact of antibiotic use on the vaginal and gut microbiomes, plus the need for caution and further research.Vaginal microbiome transplants and the potential of lactobacillus crispatus in treating BV, plus the future of an at-home vaginal microbiome test.What to consider when looking for the best women's probiotics for vaginal health, and how to avoid unnecessary products and irritants.The importance of accurate diagnosis, treatment, and management for vaginal health."When the good kind of lactobacillus are not dominating the vaginal microbial community, people are at higher risk for preterm birth, HIV acquisition, human papillomavirus—at risk for both acquisition and progression to cervical dysplasia and potentially cancer." - Dr. Caroline MitchellRelated to this episode:Resources and episodes on the Gut and Vaginal Microbiome Follow Dr. Caroline Mitchell on Instagram and LinkedIn. Follow her lab on Instagram.Learn more about Dr Mitchell's research and consider enrolling in her clinical trials MOTIF (be a donor recipient)MOTIF (be a donor) VIBRANT study, looking at a live biotherapeuticLearn about the

When you have a good thing going you often want it to last forever, but we know that can never happen. Life and the world around us are fluid, dynamic, and we're always finding the balance of fighting or harnessing entropy and inevitable change.As we encounter unexpected changes, we see them as chances to evaluate the foundations of our podcast's success while finding opportunities to evolve it and make it even better. Join us for a reflection of where we are, how we got here, and a sneak preview at what's to come. We're here to assure you, evolution is a good thing!

New endowed fund to foster next generation of women's health leaders   To close the gap between women's health research and other scientific disciplines, Ward and Mari Walstrom of Harbor Springs have made a $1 million gift to bolster education and research in the MSU College of Human Medicine's Department of Obstetrics, Gynecology and Reproductive Biology.  The Walstrom Family Endowed Women's Health Research Fund is creating an early-career training program to increase the number of scientists and clinicians pursuing a lifelong career focused on women's health care and research.  The program pairs medical and graduate students with research teams and will support independent research projects. Four College of Human Medicine early-career graduate students, including one third-year medical student, were recently selected and awarded the endowed funds; each will utilize the philanthropic funds to push forward current research projects, which would not have been otherwise possible.  Three Spartans describe the impact the gift will have on women's health. Dr. Richard Leach is professor and chair of the MSU College of Human Medicine's Department of Obstetrics, Gynecology and Reproductive Health. Shannon Harkins is a PhD candidate and Walstrom fund recipient. And Roksolana Sudyk is a future Spartan MD and Walstrom fund recipient. Conversation Highlights: (0:19) – Leach on the strengths, mission, and evolving excellence of the MSU College of Human Medicine's Department of Obstetrics, Gynecology and Reproductive Biology.   (5:01) – Leach on the Walstroms and the impact of their gift.  (11:24) – Sudyk on her path to MSU, her passion for women's health, and meeting the Walstroms. (15:54) – Harkins on her passion for women's health, her research project, and meeting the Walstroms. (31:02) – Sudyk was attracted to MSU by the College of Human Medicine's focus on women's health and equity. And she describes her research project. Listen to “MSU Today with Russ White” on the radio and through Spotify, Apple Podcasts, and wherever you get your shows.

Urinary tract infections (UTIs) are a common health issue that affect millions of people each year. These infections can spread through any part of the urinary tract, including the kidneys, ureters, bladder, and urethra. Recurrent UTIs are especially troublesome and are more common in post-menopausal women.In this episode of Our Womanity, I am joined by my colleague Female Pelvic Medicine Division Chief at University Hospitals, Cleveland, and Associate Professor of Urology and Reproductive Biology at School of Medicine, Dr. David Sheyn. We answer two questions submitted by our listeners about UTIs:Question 1: “I have been having recurring UTIs for the last 4 years and get about 6-8 a year. I just had a vaginal swab that shows the same bacteria in my urine. Could the bacteria be causing the UTIs without causing severe vaginal symptoms? I get dryness and mild itching at times but no obvious discharge so how do you treat in these situations?”Question 2: “How do I treat Aerobic Vaginitis? My doctors brush over it and don't seem to know what to do. I get recurring UTIs and now I think they're connected. I tried Metrogel (metronidazole) but Google tells me that it will not fight the bacteria. I also tried Boric acid for 14 days.”Featured in this episode: UTI causes and symptoms Antibiotics, vaginal estrogen, and other UTI treatments Pelvic floor hypertonicity Condoms, spermicides, and genetics can cause infections Drug resistant bacteriaAre you 60 years of age or older? Help Univesirty Hospitals find a way to prevent infections in the blood. A clinical research study to evaluate an investigational vaccine in adults 60 years of age or older is now enrolling: https://en-us.embracevaccinestudy.com/Submit your questions on anything and everything women's health-related and we will answer them in one of our episodes.Want more from Our Womanity?If you enjoyed this episode of Womanity, please subscribe, rate, and leave a review. Your feedback helps us continue to bring you engaging and empowering content.Follow us on social media: Instagram: @drrpope TikTok: @vulvadoctor Twitter: @drrpope LinkedIn

Born and raised in Hokkaido, Japan, Professor Ryuzo Yanagimachi, the 2023 Kyoto Prize Laureate in Basic Sciences, developed a love for nature. He became fascinated with the fertilization process of sea urchins. After studying the fertilization of fish and the life cycle of parasitic barnacles, he realized little was known about mammalian fertilization. He went on to train with Professor M.C. Chang at the Worcester Foundation for Experimental Biology, the father of mammalian in vitro fertilization and then started his own lab at the University of Hawai'i. His basic studies contributed to understanding the hidden capacity of sperm and eggs and overcoming human fertility problems. Professor Yanagimachi passed away in 2023 at the age of 95, just a few months before he was to receive his Kyoto Prize award. Dr. W. Steven Ward, Director of the Institute for Biogenesis Research at the University of Hawai'i will present Prof. Yanagimachi's life and work. Series: "Kyoto Prize Symposium" [Health and Medicine] [Science] [Show ID: 39423]

Born and raised in Hokkaido, Japan, Professor Ryuzo Yanagimachi, the 2023 Kyoto Prize Laureate in Basic Sciences, developed a love for nature. He became fascinated with the fertilization process of sea urchins. After studying the fertilization of fish and the life cycle of parasitic barnacles, he realized little was known about mammalian fertilization. He went on to train with Professor M.C. Chang at the Worcester Foundation for Experimental Biology, the father of mammalian in vitro fertilization and then started his own lab at the University of Hawai'i. His basic studies contributed to understanding the hidden capacity of sperm and eggs and overcoming human fertility problems. Professor Yanagimachi passed away in 2023 at the age of 95, just a few months before he was to receive his Kyoto Prize award. Dr. W. Steven Ward, Director of the Institute for Biogenesis Research at the University of Hawai'i will present Prof. Yanagimachi's life and work. Series: "Kyoto Prize Symposium" [Health and Medicine] [Science] [Show ID: 39423]

Born and raised in Hokkaido, Japan, Professor Ryuzo Yanagimachi, the 2023 Kyoto Prize Laureate in Basic Sciences, developed a love for nature. He became fascinated with the fertilization process of sea urchins. After studying the fertilization of fish and the life cycle of parasitic barnacles, he realized little was known about mammalian fertilization. He went on to train with Professor M.C. Chang at the Worcester Foundation for Experimental Biology, the father of mammalian in vitro fertilization and then started his own lab at the University of Hawai'i. His basic studies contributed to understanding the hidden capacity of sperm and eggs and overcoming human fertility problems. Professor Yanagimachi passed away in 2023 at the age of 95, just a few months before he was to receive his Kyoto Prize award. Dr. W. Steven Ward, Director of the Institute for Biogenesis Research at the University of Hawai'i will present Prof. Yanagimachi's life and work. Series: "Kyoto Prize Symposium" [Health and Medicine] [Science] [Show ID: 39423]

Born and raised in Hokkaido, Japan, Professor Ryuzo Yanagimachi, the 2023 Kyoto Prize Laureate in Basic Sciences, developed a love for nature. He became fascinated with the fertilization process of sea urchins. After studying the fertilization of fish and the life cycle of parasitic barnacles, he realized little was known about mammalian fertilization. He went on to train with Professor M.C. Chang at the Worcester Foundation for Experimental Biology, the father of mammalian in vitro fertilization and then started his own lab at the University of Hawai'i. His basic studies contributed to understanding the hidden capacity of sperm and eggs and overcoming human fertility problems. Professor Yanagimachi passed away in 2023 at the age of 95, just a few months before he was to receive his Kyoto Prize award. Dr. W. Steven Ward, Director of the Institute for Biogenesis Research at the University of Hawai'i will present Prof. Yanagimachi's life and work. Series: "Kyoto Prize Symposium" [Health and Medicine] [Science] [Show ID: 39423]

Born and raised in Hokkaido, Japan, Professor Ryuzo Yanagimachi, the 2023 Kyoto Prize Laureate in Basic Sciences, developed a love for nature. He became fascinated with the fertilization process of sea urchins. After studying the fertilization of fish and the life cycle of parasitic barnacles, he realized little was known about mammalian fertilization. He went on to train with Professor M.C. Chang at the Worcester Foundation for Experimental Biology, the father of mammalian in vitro fertilization and then started his own lab at the University of Hawai'i. His basic studies contributed to understanding the hidden capacity of sperm and eggs and overcoming human fertility problems. Professor Yanagimachi passed away in 2023 at the age of 95, just a few months before he was to receive his Kyoto Prize award. Dr. W. Steven Ward, Director of the Institute for Biogenesis Research at the University of Hawai'i will present Prof. Yanagimachi's life and work. Series: "Kyoto Prize Symposium" [Health and Medicine] [Science] [Show ID: 39423]

Born and raised in Hokkaido, Japan, Professor Ryuzo Yanagimachi, the 2023 Kyoto Prize Laureate in Basic Sciences, developed a love for nature. He became fascinated with the fertilization process of sea urchins. After studying the fertilization of fish and the life cycle of parasitic barnacles, he realized little was known about mammalian fertilization. He went on to train with Professor M.C. Chang at the Worcester Foundation for Experimental Biology, the father of mammalian in vitro fertilization and then started his own lab at the University of Hawai'i. His basic studies contributed to understanding the hidden capacity of sperm and eggs and overcoming human fertility problems. Professor Yanagimachi passed away in 2023 at the age of 95, just a few months before he was to receive his Kyoto Prize award. Dr. W. Steven Ward, Director of the Institute for Biogenesis Research at the University of Hawai'i will present Prof. Yanagimachi's life and work. Series: "Kyoto Prize Symposium" [Health and Medicine] [Science] [Show ID: 39423]

Stacy Wilson is a Clinical Technologist that specializes in Reproductive Biology, she joins us to discuss the profound impact that IVF has on modern families.See omnystudio.com/listener for privacy information.

Learn how your vaginal flora and gut microbiome contribute to your reproductive health. Dr. Caroline Mitchell shares her expertise and research on this important but overlooked topic.Episode SummaryIn this episode, we take an in-depth look at the delicate balance of the vaginal microbiome. Dr. Caroline Mitchell, distinguished reproductive health researcher and faculty member at the Vincent Center for Reproductive Biology at Massachusetts General Hospital, shares her profound insight on why a healthy vaginal microbiome is crucial in women's health. With a background in Women's Studies at Harvard College and groundbreaking research funded by prestigious organizations, Dr. Mitchell brings a wealth of knowledge and experience to the discussion. She explains the complexities of understanding vaginal flora, the challenges posed by bacterial vaginosis (BV), and the intriguing connections between gut health and vaginal health. Listen to learn about some of the most significant yet overlooked aspects of women's reproductive health. We discuss how to balance the vaginal microbiome, what to do about chronic bacterial vaginosis, use cases for a vaginal microbiome transplant, and what innovative treatments are emerging in women's health. Key Discussion PointsWhy a healthy vaginal microbiome is crucial for women's overall health and how imbalances can lead to conditions such as bacterial vaginosis (BV).The difficulties of limited funding and the complexity of research regarding the vaginal microbiome.Symptoms of BV, its limited treatment options, and common misdiagnoses such as vulvodynia.Yeast infection vs. BV vs. UTI symptoms.The impact of antibiotic use on the vaginal and gut microbiomes, plus the need for caution and further research.Vaginal microbiome transplants and the potential of lactobacillus crispatus in treating BV, plus the future of an at-home vaginal microbiome test.What to consider when looking for the best women's probiotics for vaginal health, and how to avoid unnecessary products and irritants.The importance of accurate diagnosis, treatment, and management for vaginal health."When the good kind of lactobacillus are not dominating the vaginal microbial community, people are at higher risk for preterm birth, HIV acquisition, human papillomavirus—at risk for both acquisition and progression to cervical dysplasia and potentially cancer." - Dr. Caroline MitchellRelated to this episode:Resources and episodes on the Gut and Vaginal Microbiome Follow Dr. Caroline Mitchell on Instagram and LinkedIn. Follow her lab on Instagram.Learn more about Dr Mitchell's research and consider enrolling in her clinical trials MOTIF (be a donor recipient)MOTIF (be a donor) VIBRANT study, looking at a live biotherapeuticLearn about the

In this episode, we talk with Dr. Camilla Hughes, Assistant Professor of Reproductive Biology in the Department of Animal Science at Penn State University. Dr. Hughes shares her background and how she got into research, some of her current research projects, and how her findings may be able to help dairy producers in the future.

In this episode, we talk with Dr. Claire Stenhouse, Assistant Professor of Reproductive Biology in the Department of Animal Science at Penn State University. Dr. Stenhouse will talk about her latest research and how it can benefit dairy and livestock producers.

We are all the product of a reproductive process, yet reproductive biology, or the study of the processes and mechanisms involved in reproduction, is not well understood. Deepening our understanding of reproductive biology is crucial to advancing assistive reproductive technologies (ART) and advancing our collective comprehension of inheritance and evolution. Our guests for this episode are a couple, and we mean a literal married couple, of reproductive biology experts. Dr. Pavla Brachova and Dr. Nehemiah Alvarez, both working in the Eastern Virginia Medical School's Department of Physiological Sciences. In their collaborative work they aim to better understand and characterize the role of RNA and cellular events that impact ovarian function in women. We learn about their work with oocytes, which are single cells that grow and mature within the ovary and once fertilized provide the foundations of an embryo capable of maturing to a new individual. They outline how they use digital PCR (dPCR) and other methods to monitor RNA regulation in single cells and how progressing this work and lead to potential RNA-based therapies. In Cassie's career corner we hear childhood stories from each guest and learn about their respective career paths, which eventually collided and merged. They share insights on the importance of having mentors experienced in your field, the challenges of shared job searching, and the joys of collaborating as a couple with shared scientific interests.Visit the Absolute Gene-ius page to learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System. 

Welcome back Gene-iuses!  Jordan and Cassie kick us off with a fun teaser of what's to come in Season 2 of the Absolute Gene-ius series.   We'll be featuring another great season of interesting guests, all using dPCR to progress their diverse research applications. This includes conversations about reproductive biology, liquid biopsy and transplantation research, CAR-T research, the role of bioinformatics in PCR assay design, micro-RNA analysis, differential gene expression analysis, and of course Cassie's Career Corner, where we get to learn about people behind the science.   This teaser, like every episode of Absolute Gene-ius, has the fun baked in to keep it all light and interesting too.  You might even hear some digital PCR jokes!  Visit the Absolute Gene-ius page to access the entire first season and to learn more about the hosts and the Applied Biosystems QuantStudio Absolute Q Digital PCR System.  

In this episode, hosts Dr. Mark Hoffman and Dr. Amy Park invite Dr. Linda Bradley to discuss advanced hysteroscopy. Linda is a professor of OB/GYN and Reproductive Biology at Cleveland Clinic as well as the Director of Center for Menstrual Disorders, Fibroids, and Hysteroscopic Services. --- EARN CME Reflect on how this Podcast applies to your day-to-day and earn free AMA PRA Category 1 CMEs: https://earnc.me/9tWZ3D --- SHOW NOTES The episode begins with Linda describing the utility of hysteroscopy: it is a great option to visualize the endocervix, endometrium, uterine healing after complicated surgeries, foreign bodies, broken IUDs, and hyperplasia. It should be used for uterine bleeding, retained products of conception, evaluating women for Asherman's, and evaluating why the endometrium is thick on ultrasound. Hysteroscopy has two main roles: diagnosis and therapeutics. Hysteroscopic surgery allows for the uninterrupted visualization and removal of pathology, as opposed to other measures like D&C where the uterus is scraped blindly. It is also great for visually-directed, targeted biopsies and treating pathologies like fibroids and polyps. Linda emphasizes that it is a disservice to women to go in blind because fibroids or cancer can be missed with blind biopsies--in fact, pipelle biopsies picked up zero polyps in their study. Hysteroscopy surgery has a faster recovery, is less invasive, has less risks of bleeding or damaging other structures, and has low risk of infection. The physicians then discuss techniques involving hysteroscopy. Linda prefers using a flexible hysteroscope that is 3.2 mm wide because dilation isn't needed. She also explains that there isn't a need for a paracervical block (just oral ibuprofen) as the patients have minimal pain when the walls of the uterus are appropriately avoided. Linda focuses on the need to believe women when they are bleeding. It takes 3-5 doctors and 3-5 years for many women to get their bleeding appropriately treated instead of trying the same medicines without success. We have the technology to do something different, and hysteroscopy is the best option to look into the uterus and understand what is going on. Mark asks about the training of physicians in hysteroscopy, and Linda responds that simulators are key in addition to having courses and mentors to teach the technique properly. Finally, the doctors finish by talking about future applications of hysteroscopy. --- RESOURCES Orlando, Megan S. MD; Bradley, Linda D. MD. Implementation of Office Hysteroscopy for the Evaluation and Treatment of Intrauterine Pathology. Obstetrics & Gynecology 140(3):p 499-513, September 2022. | DOI: 10.1097/AOG.0000000000004898

Follow along as we learn about Dr. Fuller Bazer's career journey, from his upbringing in Louisiana, his Ph.D. training at North Carolina State University in the 1960's following his military active duty in South Korea, to his early career at University of Florida before settling in at Texas A&M University in 1992. Dr. Bazer is a distinguished professor in Animal Science, College of Agriculture and Life Sciences at Texas A&M University. His research in reproductive biology focuses on uterine biology and pregnancy in livestock species.Dr. Bazer became a member of SSR in 1969, in the early years of SSR. Hear about what SSR means to Dr. Bazer, and how being a scientist in reproductive biology / animal sciences has evolved from the time SSR was created, to now. 

Amidst the beauty of parenthood, it's common for women to encounter challenges in their intimate lives. The emotional and physical changes that occur after childbirth can affect a woman's perception of herself and her sexuality.We received the question: “Can women become basically asexual after having one or more children?”In the episode, Dr. Rachel Pope is joined by expert Dr. Sheryl Kingsberg to answer it. Dr. Kingsberg is the chief of behavioral medicine at MacDonald Women's Hospital/University Hospitals Cleveland Medical Center and a Professor in Reproductive Biology, Psychiatry, and Urology at Case Western Reserve University. They discuss desire, sex drive, and the definition of Hypoactive Sexual Desire Disorder (HSDD).Featured in this episode: Shifts in desire throughout a person's life The distinction between Asexuality and HSDD Postpartum depression and Psychotherapy Other causes of low desire (This Is Your Brain On Birth Control by Sarah E. Hill)Take the Decreased Sexual Desire Screener (DSDS) Screener here.If you find that the challenges in your sex life persist or are causing significant distress, consider seeking professional help. Sex therapists and counselors specialized in sex can provide valuable guidance and support tailored to your unique situation.Submit your questions on anything and everything women's health-related and we will answer them in one of our episodes.Want more from Our Womanity?Take the Vulva Quiz to see how well you know women's bodies.Looking for practical advice for women in their 60's who want to become sexually active or want to improve their current sex life? Check out Sex in Your Sixties: Who says the fun has to stop? Written by a multidisciplinary group of health professionals who address issues such as pain with sex, low desire for sex, orgasm difficulties, your bladder and sex, same sex partners, vulvar skin conditions, trauma and more.Subscribe to our newsletter here to stay updated and not miss out on new episodes.

From cleaning dishes in a lab, to engineering, to medical school, to senior principal investigator of the "Reproductive Medicine Group" at NIEHS, listen to the amazing scientific journey of Dr. Carmen Williams, the recipient of the 2023 SSR Trainee Mentoring Award. This podcast also features Dr. Miranda Bernhardt, who, before becoming the Director of the Animal Production Core and Assistant Research Professor at the Center for Reproductive Biology at Washington State University, was a postdoctoral fellow in Dr. Williams's lab from 2011 to 2017. Mentors are themself first and foremost mentees that keep on learning throughout their career, from others, including their trainees, and from their own experience along the way.

Professor Caroline Gargett, PhD, is a National Health and Medical Research Council of Australia Leadership Fellow, Women's Health Theme Leader and heads the Endometrial Stem Cell Biology Laboratory at the Hudson Institute of Medical Research and an adjunct Professor in the Department of Obstetrics and Gynaecology, Monash University. She discovered endometrial stem/progenitor cells and investigates their role in endometrial biology, endometriosis and is developing a bioengineered cell-based therapy for treating and preventing Pelvic Organ Prolapse using endometrial mesenchymal stem cells and novel biomaterials. Her awards include the Society for Reproductive Investigation President's Achievement Award (2013), the Endometriosis Foundation of America Honoree (2011), Fellow of the Society for Reproductive Biology (2017) and co-recipient of the $1M Magee Prize for a Vaginal Stem Cells Study She is a Director of the National Stem Cell Foundation of Australia and Stem Cells Limited and Scientific Advisory Board member of the Endometriosis Foundation of America, Fondation Pour la Recherche sur Endometriose, France. She was President of the Australasian Society for Stem Cell Research (2013-2014) and Secretary of the Society for Reproductive Biology (2005-2008). She has authored 155 publications. Currently she is an Editorial Board member of Scientific Reports, Reviewing Board Member for Biology of Reproduction and former Editorial Board Member and Associate Editor for Reproductive Sciences. She previously served as Associate Editor for Fertility and Sterility and Human Reproduction. IMPACT OF OUR POP RESEARCHProf Gargett is developing the first cell-based bioengineered therapy for Pelvic Organ Prolapse (POP) using eMSC and new biomaterials. The impact of the knowledge generated in evaluating their new bioengineered therapy in a rat model of “POP” repair (2014) was the initiation of a new line of research in Urogynaecology. She and now others have progressed her pioneering research to large animal vaginal surgery models of POP, nanotechnologies and 3D (bio)printing. She trained 3 gynaecologists in this new technology, one received 3 International awards, was invited to present at a Gordon Research Conference (2016) and leads a research group in Graz, Austria. She secured 3 CIA NHMRC Project, Investigator & SIEF grants for our POP research and given 14 international invited presentations, including The Royal Society, London (2017) and IUGA Clinical Conference (2020, 2019, 2018, 2022) and was invited to join IUGA Steering Committee to create a Basic Science/Translational Research Special Interest Group and presented in the inaugural IUGA Basic Science Symposium in 2020.*******************I recommend checking out my comprehensive pelvic health education and fitness programs on my Buff Muff AppYou can also join my next 28 Day Buff Muff Challenge https://www.vaginacoach.com/buffmuffIf you are feeling social you can connect with me… On Facebook https://www.facebook.com/VagCoachOn Instagram https://www.instagram.com/vaginacoach/On Twitter https://twitter.com/VaginaCoachOn The Web www.vaginacoach.com

Guest: Oluwatosin Goje, MD Better diagnostic techniques with rapid turnover and therapies for the treatment of both acute and chronic vulvovaginitis can help address the long-term burden facing reproductive-aged women. Learn more with Dr. Tosin Goje, Associate Professor of Obstetrics/Gynecology and Reproductive Biology at the Cleveland Clinic's Lerner College of Medicine at Case Western Reserve University.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Oluwatosin Goje, MD A delay in diagnosis and treatment of vulvovaginitis can have big impacts on a patient's quality of life and their overall health. Explore how screening modalities like molecular tests and treatment guidelines from the CDC can help optimize the management of patients with vulvovaginitis with Dr. Charles Turck and Dr. Tosin Goje, Associate Professor of Obstetrics and Gynecology and Reproductive Biology at the Cleveland Clinic's Lerner College of Medicine at Case Western Reserve University.

As you know, I encourage all fertility patients to support themselves throughout their fertility journey from a mind and body perspective. I'm beyond delighted to have Alice D. Domar, Ph.D back on the podcast to talk about how to support fertility with mind/body strategies and techniques. She is the Executive Director of the Domar Centers for Mind/Body Health and the Director of Integrative Care at Boston IVF. She is an Associate Professor Obstetrics, Gynecology, and Reproductive Biology, at Harvard Medical School.   Dr. Domar established the first ever Mind/Body Center for Women's Health ~ as well as the very first Mind/Body Program for Fertility. She now teaches people strategies to reduce anxiety, depression, and distress through relaxation, mindfulness, cognitive restructuring, and yoga. Research continues to show that mind/body infertility programs not only improves psychological symptoms, but also increases pregnancy rates. We will be talking about all of this, along with her redesigned mobile app FertiCalmPro (which contains more than 500 solutions to the events and situations most likely to cause distress for anyone experiencing infertility), and her new program with Best Shot.    This discussion about the mind/body connection is so very important, because the mental and emotional strain on fertility patients is something that doesn't get enough attention. Be sure and check out Dr. Domar's books and resources for more information. Read the full show notes on Dr. Aimee's website Visit Dr. Domar's site to find her books and programs. Do you have questions about Egg Freezing?Click here to join Dr. Aimee for The Egg Freezing Class.  The next live class call is on Monday, May 15, 2023 at 4pm PST, where Dr. Aimee will explain Egg Freezing and there will be time to ask her your questions live on Zoom. Looking for the best products to support you while you're TTC? Get Dr. Aimee's brand new Conception Kit here. Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org. Other ways to connect with Dr. Aimee and The Egg Whisperer Show: Subscribe to my YouTube channel for more fertility tips!Subscribe to the newsletter to get updates

In this episode, Associate Professor and Assistant Dean of Admissions at Michigan State's College of Human Medicine discusses ChatGPT in the admissions process, gives advice for reapplicants, and explains how med school applicants should choose where to apply. [SHOW SUMMARY] Michigan State's College of Human Medicine provides an innovative, patient-centered curriculum with multiple specialties and multiple opportunities for clinical exposure. Sound appealing? Read on because today I am speaking with the Assistant Dean of Admissions at Michigan State University's College of Human Medicine. An interview with Dr. Joel Maurer, the Assistant Dean for Admissions at Michigan State University's College of Human Medicine and an Associate Professor of Obstetrics, Gynecology, and Reproductive Biology. [Show Notes] Welcome to the 522nd episode of Admissions Straight Talk. Are you ready to apply to your dream Medical Schools? Are you competitive at your target programs? Accepted's Med School Admissions Quiz can give you a quick reality check. You'll not only get an assessment, but tips on how to improve your chances of acceptance. Plus, it's all free.  Our guest today is Dr. Joel Maurer, Assistant Dean of Admissions at Michigan State University's College of Human Medicine, and an associate professor of Obstetrics, Gynecology and Reproductive Biology at MSUCHM, or College of Human Medicine.  Dr. Maurer, welcome to Admissions Straight Talk. [1:34] Thank you very much. Thank you for having me. I'm delighted to speak with you today. Can you give an overview of MSU's MD program focusing on its more distinctive elements and specifically the shared discovery curriculum? [1:38] There's a lot going on there and I'll do my best to sort of give you a quick overview. College of Human Medicine is an allopathic medical school, so it grants the MD degree. It was founded in the mid '60s as a response from the people of the state of Michigan to create a brand new medical school that would initially have its primary focus on primary care physician development. The needs of the state at that time were very much in the line of primary care, frontline care. As the college grew and matured, the needs of the state became more encompassing. And so it is a medical school, that although primary care remains a critical component of what they hope to make contributions to, it's a school that appreciates the need of physicians across the wide spectrum of healthcare. The other thing of note, historically: it was the very first four-year MD granting medical school that used the community-based model as its foundation. And so Michigan State has always had a long history of looking at pedagogical approaches and teaching, and how to teach people to teach others. And at that time, they had an opportunity to create a medical school that looked at how everyone else was doing it and trying to figure out, "Is there a way that we can do it differently and maybe better?" One of the key tenets is that it always wanted its students to learn medicine out on the front line where it was happening. And so in order to do that, they decided that maybe it was best in those formative clinical years, years three and four, to put its students more out on the frontline all across the state of Michigan in order to see medicine happening as symptoms were coming forth and not a preexisting diagnosis. And so it's been a medical school that felt that it was always important to have strategic community partners spread throughout the state, such that the first two years of medical school could be conducted on Michigan State Home Campus. But then years three and four, let's have our students learn in our existing community. So as such, we've never had our own tertiary based hospital. We've never had the Michigan State University hospitals and clinics. It's always been a school that wanted to create strategic relationships with the people and the communities ac...

Season 2, Episode 4: "Can Anyone Tell If I'm A Virgin..." For transcripts, follow the link here   Please support our show! Please consider a tax-deductible donation to our podcast via the Foundation for Delaware County, a 501c3 organization.   Every purchase of RWQ merch also helps support our show!    Please rate and review us on Apple Podcasts–and tell your friends about us!   Show Notes:  Huge shout out to Mercury Stardust (https://mercurystardust.com/merctree), Jory (@alluringskull), and Point of Pride (https://www.pointofpride.org/about) who raised over $2 MILLION during a 30hr live stream / Tik-Tok-A-Thon to support gender-affirming care at the end of March! Historical Sources Blank, Hanne. Virgin: The Untouched History. Bloomsbury Press, 2007. Moslener, Sara. Virgin Nation: Sexual Purity and American Adolescence. New York: Oxford University Press, 2015. Reinarz, Jonathan. Past Scents: Historical Perspectives on Smell. University of Illinois Press, 2014. https://www.jstor.org/stable/10.5406/j.ctt7zw5zg. Rodriguez, Sara. "Restoring 'Virginal Conditions' and Reinstating the 'Normal': Episiotomy in 1920," in Heterosexual Histories, Rebecca Davis and Michele Mitchell, eds. (New York University Press, 2021), 303-330.   Medical References Rosa M. Laterza, Mario De Gennaro, Andrea Tubaro, Heinz Koelbl.  Female pelvic congenital malformations. Part I: embryology, anatomy and surgical treatment.  European Journal of Obstetrics & Gynecology and Reproductive Biology, Volume 159, Issue 1, 2011, Pages 26-34, Scarleteen https://www.scarleteen.com/ Jen Gunter's Twitter thread about hymens/virginity: https://twitter.com/DrJenGunter/status/1192143613947457537?s=20 Moussaoui, D., Abdulcadir, J. and Yaron, M. (2022), Hymen and virginity: What every paediatrician should know. J Paediatr Child Health, 58: 382-387. https://doi-org.ezproxy.library.wisc.edu/10.1111/jpc.15887 https://www.who.int/news/item/17-10-2018-united-nations-agencies-call-for-ban-on-virginity-testing Olson RM, García-Moreno C. Virginity testing: a systematic review. Reprod Health. 2017 May 18;14(1):61. doi: 10.1186/s12978-017-0319-0. PMID: 28521813; PMCID: PMC5437416.

In this episode, Dr Brittany Barreto talks to Dr. Neel Shah, Chief Medical Officer at Maven Clinic. They discuss how Maven Clinic is reducing employer healthcare costs, the challenges in serving women in over 175 countries, and what the future is for this FemTech Unicorn.Remember to like, rate and subscribe and enjoy the episode!Guest bioDr. Neel Shah, MD, MPP, FACOG, is Chief Medical Officer of Maven Clinic, the largest virtual clinic for women's and family health, and Assistant Professor of Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School. He is the co-founder of the March for Moms Association, a coalition of more than 20 leading organizations dedicated to increasing public and private investment in the wellbeing of mothers, and the founder of Costs of Care, an NGO that curates insights from clinicians and patients to help delivery systems provide better care. His work to build equitable, trustworthy systems of care is featured in the documentaries “Color of Care,” produced by Oprah Winfrey, and “Aftershock,” produced by Yance Ford. Dr. Shah serves on the advisory board of the National Institutes of Health, Office of Women's Health Research.Company bioMaven is the largest virtual clinic for women's and family health, offering continuous, holistic care for fertility and family building through maternity, parenting, pediatrics and menopause. Maven's award-winning digital programs are trusted by leading employers and health plans to reduce costs and drive better maternal health outcomes, as well as enhance DE&I in benefits programs. Founded in 2014 by CEO Kate Ryder, Maven has been recognized as Fast Company's #1 Most Innovative Health Company and has 15 million lives under management. Maven has raised $300 million in funding from leading investors including General Catalyst, Sequoia, Oak HC/FT, Dragoneer Investment Group and Lux Capital. FemTech Focus Podcast bioThe FemTech Focus Podcast is brought to you by FemHealth Insights, the leader in Women's Health market research and consulting. In this show, Dr. Brittany Barreto hosts meaningfully provocative conversations that bring FemTech experts - including doctors, scientists, inventors, and founders - on air to talk about the innovative technology, services, and products (collectively known as FemTech) that are improving women's health and wellness. Though many leaders in FemTech are women, this podcast is not specifically about female founders, nor is it geared toward a specifically female audience. The podcast gives our host, Dr. Brittany Barreto, and guests an engaging, friendly environment to learn about the past, present, and future of women's health and wellness.FemHealth Insights bioLed by a team of analysts and advisors who specialize in female health, FemHealth Insights is a female health-specific market research and analysis firm, offering businesses in diverse industries unparalleled access to the comprehensive data and insights needed to illuminate areas of untapped potential in the nuanced women's health market.Time Stamps[02:52] Dr. Neels Shah's background[04:27] Academics and Startups[08:04] All about Maven Clinic[18:38] Advice for founders thinking about business models[10:50] How medical insurance works in the US[22:28] Maternal care costs[26:43] Challenges of serving women in 175+ countries[28:36] Male usage of Maven[32:18] Maven and Menopause[36:12] Building Maven[38:25] Focus V Marketplace[39:48] Maven's Exit StrategyResourcesMaven ClinicMarch for MomsCosts of CareThe Color of CareAftershockCall To Action!Make sure you subscribe to the podcast, and if you like the show please leave us a review!Sponsor InformationToday's episode is sponsored by Guidea, a women-owned, women-led UX design consultancy that specializes in bringing FemTech innovations to life. This incredible team has extensive product and design strategy expertise in HealthTech and MedTech and is a trusted partner to 20 of the Fortune 100 companies. They've launched more than  300 products to date including the flagship products for seven unicorn-status start-ups. Guidea is known for creating research-driven products and services that are engaging, useful, and easily integrated into patients' or customers' lives and care providers' workflows. Drawing on their deep knowledge of MedTech, IoT, wearables, population health insights, digital therapeutics, and healthcare software, they help founding teams prioritize opportunities and focus on key features for clinical studies or MVPs. The team also has extensive experience with regulated device approval and can help you both understand and plan for this rigorous testing and approval process. To learn more about Guidea and get to know their team, visit guidea.com. Episode ContributorsDr. Neel ShahLinkedIn: @Neel ShahTwitter: @neel_shahMaven ClinicWebsite: https://www.mavenclinic.com/LinkedIn: @Maven ClinicTwitter: @mavenclinicInstagram: @mavenclinicDr Brittany BarretoLinkedIn: https://www.linkedin.com/in/brittanybarreto/Twitter: @DrBrittBInstagram: @drbrittanybarretoFemTech Focus PodcastWebsite: https://femtechfocus.org/LinkedIn: https://www.linkedin.com/company/femtechfocusTwitter: @FemTech_FocusInstagram: @femtechfocusFemHealth InsightsWebsite: https://www.femhealthinsights.com/LinkedIn: @FemHealth Insights

Survey: https://bit.ly/feedback_UltraSounds Theresa and Rachel discuss postpartum hemorrhage with Dr. Luke Burns. 00:30 Dr. Burns Biography 01:50 Case 1: 35 year old G4P4 with polyhydramnios, boggy uterus 09:17 Case 2: 35 year old G4P4 with postpartum hemorrhage and chronic hypertension 16:53 Case 3: hemodynamically unstable 35 year old G4P4 with postpartum hemorrhage 23:59 Case 4: 35 year old G4P4 with no return of menstruation Transcript: https://bit.ly/Ultrasounds_PPH Trends in maternal mortality: 2000 to 2017: estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division. Geneva: World Health Organization; 2019. ACOG Practice Bulletin No. 183: Postpartum Hemorrhage. Obstet Gynecol 2017, 30(4). Wormer KC, Jamil RT, Bryant SB. Acute Postpartum Hemorrhage. StatPearls Publishing; 2022 Jan. ACOG Committee Opinion No. 794: Quantitative blood loss in obstetric hemorrhage. American College of Obstetricians and Gynecologists. Obstet Gynecol 2019;134. Bell, S. F., et al (2020). Incidence of postpartum haemorrhage defined by quantitative blood loss measurement: a national cohort. BMC pregnancy and childbirth, 20(1), 271. Parry Smith WR, et al. Uterotonic agents for first‐line treatment of postpartum haemorrhage: a network meta‐analysis. Cochrane Database of Systematic Reviews 2020, Issue 11. Vogel JP, et al. WHO recommendations on uterotonics for postpartum haemorrhage prevention: what works, and which one? BMJ Global Health 2019. A. Borovac-Pinheiro, et al. (2018). Postpartum hemorrhage: new insights for definition and diagnosis. American Journal of Obstetrics and Gynecology, 219(2):162-8. A. Leleu, et al. (2021). Intrauterine balloon tamponade in the management of severe postpartum haemorrhage after vaginal delivery: Is the failure early predictable?. European Journal of Obstetrics & Gynecology and Reproductive Biology, 258:317-323. Schury MP, Adigun R. Sheehan Syndrome. StatPearls Publishing; 2022 Jan.

As you know, I encourage all fertility patients to support themselves throughout their fertility journey from a mind and body perspective. I'm beyond delighted to have Alice D. Domar, Ph.D back on the podcast to talk about how to support fertility with mind/body strategies and techniques. She is the Executive Director of the Domar Centers for Mind/Body Health and the Director of Integrative Care at Boston IVF. She is an Associate Professor Obstetrics, Gynecology, and Reproductive Biology, at Harvard Medical School.   Dr. Domar established the first ever Mind/Body Center for Women's Health ~ as well as the very first Mind/Body Program for Fertility. She now teaches people strategies to reduce anxiety, depression, and distress through relaxation, mindfulness, cognitive restructuring, and yoga. Research continues to show that mind/body infertility programs not only improves psychological symptoms, but also increases pregnancy rates. We will be talking about all of this, along with her redesigned mobile app FertiCalmPro (which contains more than 500 solutions to the events and situations most likely to cause distress for anyone experiencing infertility), and her new program with Best Shot.    This discussion about the mind/body connection is so very important, because the mental and emotional strain on fertility patients is something that doesn't get enough attention. Be sure and check out Dr. Domar's books and resources for more information. Read the full show notes on Dr. Aimee's website Do you have questions about IVF?Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, December 5, 2022 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.   Subscribe to my YouTube channel for more fertility tips!  Subscribe to the newsletter to get updates Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.

For this episode of BackTable OBGYN, Drs. Park and Hoffman invite Dr. Louise King, MD, JD of Brigham and Women's Hospital to talk about the legal perspective of Roe v. Wade. --- EARN CME Reflect on how this Podcast applies to your day-to-day and earn AMA PRA Category 1 CMEs: https://earnc.me/00DKvR --- SHOW NOTES Dr. King, who works in the Division of Minimally Invasive Gynecologic Surgery, is also an Assistant Professor and Obstetrics, Gynecology and Reproductive Biology and the Director of Reproductive Bioethics at Harvard Medical School. Initially a lawyer of constitutional law, Dr. King utilizes the combination of her legal training with her medical knowledge to educate patients and colleagues on the essential and compassionate delivery of abortion healthcare. The episode begins with Dr. King providing the legal history of reproductive care in the United States. She walks listeners through a timeline that includes the Comstock laws, as well as U.S. Supreme Court decisions, including Griswold v. Connecticut, Roe v. Wade, and Dobbs v. Jackson Women's Health Organization. When discussing the history, Dr. King emphasizes the role of healthcare professionals in combating the current legal state. Specifically, she urges listeners to go beyond simply stating that discussions about abortion should remain between physicians and patients. Instead, she shares how providers should continue the conversation by vocalizing what abortion is, why it is essential, what makes it a complex topic, and why each person should defend the right for themselves and others. Dr. King then describes how to develop a space that promotes others to engage in conversation about abortion. Her approach to this dialogue includes allowing people to identify what gives them pause and determining ways to validate someone's discomfort about the topic. Dr. King provides examples of how she frames her discussion with medical students at Harvard Medical School, which involves utilization of the pillars of ethics as a scaffolding for conversation. She then goes on to define reproductive justice for listeners. Lastly, Dr. King charges the audience to practice their first amendment right and educate about abortion care. She also discusses the developing course for OBGYN residency programs and acknowledges the varying levels of training based on geographical location. The episode concludes with Dr. King sharing avenues of support for physicians who regularly practice abortion care.

*The information in this podcast is intended for Healthcare Practitioners. Endometriosis is a common and debilitating condition that has proven difficult to treat. In this episode, Sun-Wei Guo, a geneticist turned Professor of Gynaecology, reveals his eye-opening research into the pathophysiology of endometriosis. Sun Wei explains how the theory of retrograde flow in endometriosis is necessary but not sufficient to explain the progression of the disease. Prof Guo explains that endometriotic lesions are wounds undergoing repeated tissue injury and repair (ReTIAR). Sun Wei further describes how surprising mediators in the endometriotic microenvironment are responsible for the incomplete repair process that leads to the cellular hallmarks of endometriosis. Hear about Prof Guo's preliminary work on herbal constituents and electrical stimulation that are generating encouraging results in endometriosis. Listen in to discover new non-hormonal targets that can be considered to combat this terrible affliction. Professor Guo received his Ph.D. from the University of Washington and had subsequent stints at University of Michigan and the Medical College of Wisconsin. Since 2010 Sun Wei has been a Professor at Shanghai OB/GYN Hospital, Fudan University and an adjunct professor at Department of Obstetrics, Gynecology and Reproductive Biology at Michigan State University College of Human Medicine. Prof Guo has been an Associated Editor of several reproduction journals and a board member of several endometriosis societies, including member of the Board of Trustees of the World Endometriosis Society (WES). Links: Guo SW. Fibrogenesis resulting from cyclic bleeding: the Holy Grail of the natural history of ectopic endometrium. Hum Reprod. 2018 Mar 1;33(3):353-356. https://pubmed.ncbi.nlm.nih.gov/29420711/ Xiao F, Liu X, Guo SW. Platelets and Regulatory T Cells May Induce a Type 2 Immunity That Is Conducive to the Progression and Fibrogenesis of Endometriosis. Front Immunol. 2020 Dec 14;11:610963. https://pubmed.ncbi.nlm.nih.gov/33381124/ Yan D, Liu X, Guo SW. Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis. Sci Rep. 2019 Feb 25;9(1):2698. https://pubmed.ncbi.nlm.nih.gov/30804432/ Huang S, Xiao F, Guo SW, Zhang T. Tetramethylpyrazine Retards the Progression and Fibrogenesis of Endometriosis. Reprod Sci. 2022 Apr;29(4):1170-1187. https://pubmed.ncbi.nlm.nih.gov/35099777/ Hao M, Liu X, Rong P, Li S, Guo SW. Reduced vagal tone in women with endometriosis and auricular vagus nerve stimulation as a potential therapeutic approach. Sci Rep. 2021 Jan 14;11(1):1345. https://pubmed.ncbi.nlm.nih.gov/33446725/ Hao M, Liu X, Guo SW. Activation of α7 nicotinic acetylcholine receptor retards the development of endometriosis. Reprod Biol Endocrinol. 2022 Jun 4;20(1):85. https://pubmed.ncbi.nlm.nih.gov/35658970/

Veteran A&P educator and reproduction researcher Dr. Margaret Reece joins host Kevin Patton to talk about challenges of teaching human reproduction and development. Reece also briefly discusses her online resources (MedicalScienceNavigator.com) and her experiences in helping overwhelmed A&P students succeed in their studies. 00:00 | Introduction 00:43 | Reproductive Biology 08:13 | Sponsored by AAA 08:58 | Ultrasound & Reproductive Biology 20:25 | Sponsored by HAPI 21:13 | Basic Science 35:27 | Sponsored by HAPS 36:33 | Medical Science Navigator 50:19 | Staying Connected   ★ If you cannot see or activate the audio player, go to: theAPprofessor.org/podcast-episode-122.html

Avroy A. Fanaroff, MD was the Gertrude Lee Chandler Tucker Professor and Chair of the Department of Pediatrics and Reproductive Biology at Case Western Reserve University School of Medicine. He also served as the Director of Neonatology and physician in chief at Rainbow Babies and Children's Hospital in Cleveland. He is currently Emeritus Professor Case Western Reserve University, and Eliza Henry barnes Chair of Neonatology. He is globally acknowledged as an international authority in the field of neonatology, and has contributed greatly to literature in the area of neonatal medicine, with particular focus on pulmonology, nutrition, and sepsis. He is co-editor of Fanaroff and Martin's Neonatal-Perinatal Medicine and Klaus and Fanaroff's Care of the High-Risk Neonate. Dr. Fanaroff has been recognized for his contributions to the field with numerous honors and awards, including the Apgar Award, the Professional Education Award and the National Neonataology Education Award from the American Academy of Pediatrics, and has been honored with an honorary fellowship from the Royal College of Pediatrics and Child Health in London and honorary doctorates from the University of the Witwatersrand (his alma mater) and the University of Turku, Finland.Find out more about Avroy and this episode at: www.nicupodcast.com________________________________________________________________________________________As always, feel free to send us questions, comments or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through instagram or twitter, @nicupodcast. Or contact Ben and Daphna directly via their twitter profiles: @drnicu and @doctordaphnamd. enjoy!This podcast is proudly sponsored by Chiesi.

Welcome to the latest episode of the I3 podcast where we're going to be discussing a recent session held by I3 on Misconceptions which discussed a number of curious oddities within the studies of Embryology. It was called Misconceptions and we highly recommend you rewatch it to, scroll down for the link. During the session there was a talk from Dr. Sourima Shivhare who is a Health and Care Professions Council (HCPC) registered Senior Clinical Embryologist, working at The Centre for Reproductive and Genetic Health, London. She is also a lecturer and external assessor on the MSc in Clinical Embryology (University of Oxford). Dr Shivhare spoke in more detail to Giles Palmer about her insights from her studies, following on from a paper Giles had told her about by John Wallington, which debated the origins of Embryology. The paper highlights how common European names such as Aristotle and Hippocrates shouldn't be the only ones mentioned and Dr Shivhare discussed with Giles about her surprise at finding out that the concept of conception and embryology existed much earlier in one of the oldest scriptures. What was discussed: Papers that have come out of Indian mentioning embryology in ancient scriptures and in the Koran, however, it is John Wallingford's paper that mentions themNames within standard textbooks such as Aristotle, and Hippocrates - all-white European How much of the history of Embryology is actually studied in trainingCurrently, the definition of science is based on evidence - so can religious scriptures be considered primarily as they are then translated, meaning we can't check for accuracy. Hippocrates - Father of Medicine 500 BCThe Veydic Period between 1500 - 300 BCE and the oldest scripture mentioning the development of the embryo in the womb, mention within 24 hours something happening and the ‘bubble' alluding to blastocyst. Twin conception mentioned within the papers17th Century - in Europe talking about pre-formations, before that in Asia conclusions on this development was being discussed.We shouldn't get bogged down that these are religious texts as that is how words were spread at that timeHow the definition of religion has also changed vastly over the centuries - more like a way of life rather than following a deity. Great minds were often religious—unity between religion and science. You will also hear the after-party which took place after the session. Speakers include: Dr Don Rieger- Oddities in Reproductive Biology, Dr Sourima Biswas Shivhare- A little Less Eurocentric, Modestly Universal View of the History of Embryology and Dr Shubhangi Gangal - The Story of Subhash MukhopadhyayWatch the Misconceptions session here Follow us on our socials: TwitterFacebook InstagramYou Tube

Welcome, Tracey Cook is the Podcast Host for the podcast series Victim to Victory. This series gives a voice to those who have overcome challenges in all forms, that dare greatly to share their real stories, that have seen hope and rose above those adversities to become victorious, to go on to support and inspire others to do the same. Dr. Bob Clarke is an award-winning online marketer, best-selling author, speaker and blogger who specializes in helping ordinary employees transform into extraordinary entrepreneurs. Born in New Jersey, he graduated from Rutgers University in 1979 and received his Ph.D. in Reproductive Biology from the University of Maryland in 1985. Dr. Bob worked for over 30 years in the infertility field and helped run in vitrofertilization laboratories in New York and Boston. During that time, he had a role in over 25,000 births, helping couples achieve their desire of starting and growing their families. In 2009, Dr. Bob and his wife Rosemary started an online business while still working full time, to provide choices when they decided to hang up their lab coats and leave their healthcare careers. Dr. Bob perfected strategies and systems for building a business “part-time” while still working a full-time job and began coaching others to grow their businesses in 1-2 hours/day. On October 25, 2019, Dr. Bob retired from the healthcare industry to work his online business full time. He and his wife moved to beautiful Naples, Florida where they still reside. Dr. Bob is a top affiliate for a major attraction marketing/lead generation program, a sought-after trainer/coach and continues to help others who are struggling to build their businesses part-time. He is a contributing author of the top-selling book Life By Design, published in 2022 and is now working on his first solo book to be released next year. You can learn more about Dr. Bob and his unique approach to building a side business at his blog, Simple Solutions for Part-Time Entrepreneurs at https://BobandRosemary.com. Connect with Bob Clarke here: Resource https://bobandrosemary.com/plan Victim to Victory Facebook group: https://www.facebook.com/groups/victi... Please subscribe, like, comment and share Listen on Spotify and download the podcast series https://open.spotify.com/episode/0vmg.... Join our newsletter here: https://mlsp.co/l8a2f Want to be a podcast guest? www.traceyleecook.com --- Send in a voice message: https://anchor.fm/victim-to-victory/message

Dr Scarlett Smash makes Dr Craken take her naughty dolphin quiz - will he be able to answer the questions, or will he be a dolphin dunce? Listen to find out! This episode is supported by an ad from Cetacean Research Technology - providers of affordable, top quality hydrophones to scientists, documentary makers, artists, educators, whale-watchers and all types of ocean enthusiast! https://www.cetaceanresearch.com/index.html If you liked this show please support us so we can keep providing more content,  $1 helps : www.patreon.com/marineconservation  Contact info@absolutelysmashingllc.com for more information about sponsoring MCHH episodes or having advertisments on the show. MCHH Twitter MCHH Fb Live Dr Scarlett Smash YouTube Dr Scarlett Smash Twitter  Dr Scarlett Smash Instagram Dr Scarlett Smash TikTok  Dr Craken MacCraic Twitter Dr Craken MacCraic Instagram MCHH Instagram  

On this week's episode of Here for Her Health, presented by Organon, our host Wendy Lund gets a chance to chat with Dr. Neel Shah, Chief Medical Officer of Maven Clinic, the world's largest virtual clinic for women's and family health, and Assistant Professor of Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School. Throughout his career, Dr. Shah has been a globally recognized expert in designing solutions that improve health care, and in 2014 was listed among the "40 smartest people in health care" by the Becker's Hospital Review. He joins us today to destigmatize women's health issues such as menstruation and menopause, and shine a light on conditions that are often overlooked. So get ready for another episode of Here for Her Health, building a better, healthier, every day for women! Follow UsInstagram (@hereforherhealth)Presented by Organon

In 1979, 4-year-old Ilona and her parents came to the US from the former Soviet Union. In this episode of TBA Now! Ilona discusses the difficulties and successes that she and her family encountered as Jewish refugees. Hear the hilarious and poignant story of their first Passover Seder in their new home country and how Ilona has found a deep and meaningful connection as a Reform Jew. Wanting to be a doctor for as long as she recalls, Ilona explains how she found her passion in the field of high-risk obstetrics. Listen to find out more about this gutte neshuma (good soul). Ilona Goldfarb is an Assistant Professor in Obstetrics, Gynecology, and Reproductive Biology at Harvard Medical School and a Maternal Fetal Medicine specialist at Mass General Hospital with a focus on patient and provider attitudes around vaccination during pregnancy.

In this episode we discuss how maternal health is a bellwether for societal health, why black women are 3x more likely to experience maternal mortality, the power in simplifying your vision for your life and much more. Our guest, Dr. Neel Shah, MD, MPP, FACOG, is Chief Medical Officer of Maven Clinic, the world's largest virtual clinic for women's and family health, and Assistant Professor of Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School. He is a globally recognized expert in designing solutions that improve health care, and is listed among the "40 smartest people in health care" by the Becker's Hospital Review. Dr. Shah's work to build equitable, trustworthy systems of care has been profiled by the New York Times, Wall Street Journal, Good Morning America other outlets. He is featured in the films Aftershock, which won the Special Jury Prize for Impact at the 2022 Sundance Film Festival, and The Color of Care, released in 2022 by Executive Producer Oprah Winfrey and the Smithsonian Channel. Prior to joining the Harvard faculty, Dr. Shah founded Costs of Care, an NGO that curates insights from clinicians and patients to help delivery systems provide better care. In 2017, he co-founded the March for Moms Association, a coalition of more than 20 leading organizations, to increase public and private investment in the wellbeing of mothers. Dr. Shah serves on the advisory board of the National Institutes of Health, Office of Women's Health Research.

Women who are dealing with PAINFUL SEX not only need to medically eliminate the cause of the pain, but also need to repair the PSYCHOLOGICAL IMPACT of either avoiding or enduring agonizing sexual activity for months or years. In this episode Dr. Streicher sits down with Sheryl Kingsberg PhD to discuss strategies for couples and individuals to navigate sex when there is pain. She also reveals exciting research in female sexuality. Dr. Kingsberg is a clinical psychologist, a Professor of Reproductive Biology and Psychiatry at Case Western Reserve University and one of the country's foremost experts and researchers in human sexuality.   Dr. Streicher and Dr. Kingsberg will discuss:  WHAT happens to relationships when sex is PAINFUL WHAT is vaginismus and why does it happen? WHY it is sometimes important to temporarily stop having intercourse How to have sex when intercourse is off the table What is SEX THERAPY? The difference between a general therapist and a sex therapist How to have a therapist who specialized  How to TALK to your partner about painful sex Dr. Kingsberg's Research: VIAGRA, TESTOSTERONE, LIBIDO drugs for women More information about treating painful intercourse post menopause can be found in:  Slip Sliding Away: Turning Back the Clock on Your Vagina-A gynecologist's guide to eliminating post-menopause dryness and pain To find a certified sex therapist:  www.AASECT.org  The American Association of Sexuality Educators, Counselors and Therapists  www.SSTARR.org  The Society for Sex Therapist &Research Lauren Streicher, MD is a clinical professor of obstetrics and gynecology at Northwestern University's Feinberg School of Medicine, and the medical director of the Northwestern Medicine Center for Sexual Medicine and Menopause. She is a certified menopause practitioner of the North American Menopause Society.  Dr. Streicher is the medical correspondent for Chicago's top-rated news program, the WGNMorningNews, and has been seen on The Today Show, Good Morning America, The Oprah Winfrey Show, CNN, NPR, Dr.Radio,Nightline,Fox and Friends, The Steve Harvey Show, CBS ThisMorning,ABCNewsNow,NBCNightlyNews,20/20, and WorldNewsTonight. She is an expert source for many magazines and serves on the medical advisory board of The Kinsey Institute, Self Magazine and Prevention Magazine. She writes a regular column for The Ethel by AARP and Prevention Magazine.  Subscribe and Follow Dr. Streicher on  DrStreicher.com Instagram @DrStreich Twitter @DrStreicher Facebook  @DrStreicher YouTube  DrStreicherTV Dr. Streicher's Books  Slip Sliding Away: Turning Back the Clock On Your Vagina-A gynecologist's guide to eliminating post-menopause dryness and pain Hot Flash Hell: A Gynecologist's Guide to Turning Down the Heat Sex Rx- Hormones , Health, and Your Best Sex Ever The Essential Guide to Hysterectomy

Bret Anderson was born in Alabama at the conclusion of his father's Air Force service. He was raised in western Washington in a small agriculturally based city of 6000 people. He briefly attended a junior college with an interest in Civil Engineering.  He was called to serve as a missionary in the Japan, Tokyo South Mission (1987 to 1989). Bret loved every bit of his mission and learned to love the Japanese people. Upon his return from Japan, he started school at BYU. He changed his major from Civil Engineering to Agribusiness. Bret loved the mix of biology and business. While at BYU Bret met and married his bride.  After graduation, they moved to Logan Utah to do a Master's in Reproductive Biology and Endocrinology. It was here that Bret made the decision to use his knowledge and skills to help multiply and replenish eternal families instead of cattle, goats, sheep, pigs, or horses.  His first job was in Los Angeles, California, working for the largest fertility clinic on the west coast. In 1999, he moved to Boise to help the people of Idaho in their struggle from infertility to family.  Bret enjoys spending time outside with his family hiking, camping, or on the lake.  A personal interest in road cycling. Together with his wife Sharon, they have 4 children.

In this episode of YOUR FERTILITY STORY, Maria focuses on your clinic selection. Her guest on this episode is Eva Schenkman, an embryologist of nearly 30 years. She completed her undergraduate at Cornell University and went on to complete her master's degree and Ph.D. at Eastern Virginia Medical School. In recent years, she's become a consultant and runs the New York Metropolitan Embryology Society. She is also a clinical instructor at the EVMS Master's Program in Embryology and sits on several committees for the Society of Reproductive Biologists and Technologists as well as the College of Reproductive Biology.   In this episode, you'll hear:   Eva Schenkman's tips for researching fertility clinics for your particular needs and what you should look for. Why a clinic might not have its own embryologists on staff and may outsource for that service. The categories and data you should be evaluating as you review your clinical options. What you need to look out for if you're considering a clinic with a narrow specialization or innovative treatments. Her advice for selecting the right clinic for you and what you should look for in the clinic's communication with you.   Connect with Maria Feekes here: mariafeekes.com Adonisfertilityintl.com facebook.com/AdonisFertilityInternational instagram.com/adonis.fertility.international youtube.com/channel/UCWSEMH4ce2qkzW4mf4o0I6A   Connect with Eva Schenkman here: linkedin.com/in/eva-schenkman-6121778/