Podcasts about Orlowski

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Listen in as Jesse Orlowski, one of our church members, shares his experience about his time spent last summer in Seoul, Korea at the L'Abri retreat. Jesse shares what he learned, both culturally and spiritually, and continues in interview format answering questions from Pastor Frank.

Welcome to another episode of the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Robert Orlowski from MD Anderson Cancer Center to discuss groundbreaking studies presented at ASH 2024 focused on multiple myeloma. We dived into four key studies: 1.⁠ ⁠AQUILA: Explore the impact of early intervention using daratumumab for smoldering myeloma, which showed improved progression-free survival (PFS) and overall survival (OS). 2.⁠ ⁠Dara Based Quad Therapy: We discuss a meta-analysis reaffirming the use of quadruplet therapy with anti-CD38 for newly diagnosed multiple myeloma as the standard of care. 3.⁠ CARTITUDE-4: study highlights the benefits of CAR-T therapy in earlier lines of treatment for patients with lenalidomide-refractory disease. 4.⁠ ⁠Role of IVIG with BCMA Bispecific Antibodies: Discover how IVIG can reduce infection rates and improve overall survival when used alongside BCMA-targeted therapies. Tune in for an insightful discussion that will enhance your understanding of the latest advancements in multiple myeloma treatment. Don't forget to check out our other episodes on CLL, myeloma, and lymphoma from ASH 2024! Subscribe to the Oncology Brothers for more updates and expert insights in oncology! Website: http://www.oncbrothers.com/  X/Twitter: https://twitter.com/oncbrothers  Contact us at info@oncbrothers.com

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Ryan and Rachelle visit with Theresa Abel, owner/curator of Abel Contemporary Gallery and Ann Orlowski, the gallery director about "The Cup Show" and much more.

Join Chris Matheson as he dives deep into the latest M-Step results with CS Partner's Director of Professional Learning/S2, Nick Orlowski. In this enlightening episode, they explore how socioeconomic status shapes educational outcomes and what it means for our schools and students. Tune in for insights that challenge the status quo and inspire change in our education system!

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

In this podcast series, Dr. Orlowski, Dr. Raje, and Dr. Voorhees inform and guide participants on latest developments from clinical trials on quadruplet and triplet regimens, based on updates from the European Hematology Association (EHA) 2024 meeting. Using clinical case scenarios, they'll clarify clinical endpoints and outcomes to enable safe and effective frontline regimen choices among diverse patients with newly diagnosed multiple myeloma (NDMM) who have distinct needs. Listen to the available episodes as experts lay the foundation for optimal first-line, maintenance, transplantation, and subsequent therapy choice based on the risk profile of patients, to ultimately improve outcomes in multiple myeloma (MM).Launch Date: July 19, 2024Release Date: June 26, 2024Expiration Date: June 30, 2025FACULTYRobert Orlowski, MD, PhDProfessor of MedicineDirector, Section of MyelomaThe University of Texas, MD Anderson Cancer CenterNoopur Raje, MDDirector, Center for Multiple MyelomaMassachusetts General HospitalPeter Voorhees, MDChief, Plasma Cell Disorders DivisionAtrium Health / Levine Cancer InstituteClinical Professor of MedicineWake Forest University School of MedicineThis podcast provides accredited continuing education credits.  To receive your credit, please read the accreditation information provided at this link below prior to listening to this podcast.https://www.practicepointcme.com/CMEHome/integrating-quadruplet-regimens-in-newly-diagnosed-multiple-myeloma-patient-focused-strategies-to-improve-outcomes-43

In this podcast series, Dr. Orlowski, Dr. Raje, and Dr. Voorhees inform and guide participants on latest developments from clinical trials on quadruplet and triplet regimens, based on updates from the European Hematology Association (EHA) 2024 meeting. Using clinical case scenarios, they'll clarify clinical endpoints and outcomes to enable safe and effective frontline regimen choices among diverse patients with newly diagnosed multiple myeloma (NDMM) who have distinct needs. Listen to the available episodes as experts lay the foundation for optimal first-line, maintenance, transplantation, and subsequent therapy choice based on the risk profile of patients, to ultimately improve outcomes in multiple myeloma (MM).Launch Date: July 19, 2024Release Date: June 26, 2024Expiration Date: June 30, 2025FACULTYRobert Orlowski, MD, PhDProfessor of MedicineDirector, Section of MyelomaThe University of Texas, MD Anderson Cancer CenterNoopur Raje, MDDirector, Center for Multiple MyelomaMassachusetts General HospitalPeter Voorhees, MDChief, Plasma Cell Disorders DivisionAtrium Health / Levine Cancer InstituteClinical Professor of MedicineWake Forest University School of MedicineThis podcast provides accredited continuing education credits.  To receive your credit, please read the accreditation information provided at this link below prior to listening to this podcast.https://www.practicepointcme.com/CMEHome/integrating-quadruplet-regimens-in-newly-diagnosed-multiple-myeloma-patient-focused-strategies-to-improve-outcomes-43

In this podcast series, Dr. Orlowski, Dr. Raje, and Dr. Voorhees inform and guide participants on latest developments from clinical trials on quadruplet and triplet regimens, based on updates from the European Hematology Association (EHA) 2024 meeting. Using clinical case scenarios, they'll clarify clinical endpoints and outcomes to enable safe and effective frontline regimen choices among diverse patients with newly diagnosed multiple myeloma (NDMM) who have distinct needs. Listen to the available episodes as experts lay the foundation for optimal first-line, maintenance, transplantation, and subsequent therapy choice based on the risk profile of patients, to ultimately improve outcomes in multiple myeloma (MM).Launch Date: July 19, 2024Release Date: June 26, 2024Expiration Date: June 30, 2025FACULTYRobert Orlowski, MD, PhDProfessor of MedicineDirector, Section of MyelomaThe University of Texas, MD Anderson Cancer CenterNoopur Raje, MDDirector, Center for Multiple MyelomaMassachusetts General HospitalPeter Voorhees, MDChief, Plasma Cell Disorders DivisionAtrium Health / Levine Cancer InstituteClinical Professor of MedicineWake Forest University School of MedicineThis podcast provides accredited continuing education credits.  To receive your credit, please read the accreditation information provided at this link below prior to listening to this podcast.https://www.practicepointcme.com/CMEHome/integrating-quadruplet-regimens-in-newly-diagnosed-multiple-myeloma-patient-focused-strategies-to-improve-outcomes-43

Today we've got a guest who's been doing our job for decades. Andrew Orlowski is a writer who has followed the technology industry for two decades, so he's see the hype cycle peak and trough many times.For more on Bubble Trouble, including transcripts of the show, visit us online at http://bubbletroublepodcast.comYou can learn more about Richard at https://www.linkedin.com/in/richard-kramer-16306b2/More on Will Page at: https://pivotaleconomics.com(Times below correspond to the episode without considering any inserted advertisements.)In this episode of Bubble Trouble, hosts Richard Kramer and Will Page are joined by veteran technology journalist Andrew Orlowski. They delve into the recurring market bubbles and dissect the relentless hype surrounding AI and machine learning. Orlowski discusses his track record in identifying technology bubbles and shares his skepticism about the transformative claims made about AI, comparing it to historical overhyped innovations like the metaverse and cryptocurrency. The discussion also touches on the implications of AI on productivity, labor markets, and the economy at large, highlighting the disconnect between policy elites' expectations and real-world applications. Throughout, the panel emphasizes the broader societal impacts and the role of critical scrutiny in understanding technological advancements.00:00 Introduction to Bubble Trouble00:44 Part One00:49 Meet Andrew Orlowski01:43 The Origins of Bubble Trouble02:06 Spotting Bubbles: Andrew's Track Record02:39 Google's Market Manipulation07:00 The AI Hype Cycle12:08 AI's Economic Impact and Skepticism19:10 The Future of AI and Technology26:13 Debunking the Efficiency Myth in Tech Companies26:39 The Role of AI in Financial Markets28:10 AI Skepticism and the Hype Cycle28:20 Part Two29:02 The Future of Chatbots and Machine Learning30:06 Public Skepticism vs. Elite Optimism35:54 The Nature of Work and Productivity42:13 The Middle Class Advantage in the Modern Workplace45:40 The AI Bubble and Its Implications49:01 Smoke Signals: Red Flags in the AI Industry51:19 Conclusion and Final Thoughts51:51 Credits Hosted on Acast. See acast.com/privacy for more information.

Dr Orlowski discusses key efficacy data from the IMROZ trial of Isa-VRd in newly diagnosed, transplant-ineligible multiple myeloma.

Orlowski, Corinne www.deutschlandfunk.de, Kultur heute

On this episode of the Club + Resort Talks podcast, Rob Thomas, Editor-in-Chief of Club + Resort Business, chats with Brock Orlowski, MBA, CDORS, USPTA Elite, PPR, Director of Racquet Sports at Fort Wayne (Ind.) Country Club. The two talk about everything from growing the racquets industry through The Directors' Club of America and the inaugural Directors' Club Retreat, to cultivating the rapidly growing interest in racquet sports—pickleball, tennis, padel, and more. Rob and Senior Editor Phil Keren also discussed some innovative projects and events happening at golf courses around the country. Canal Shores golf course in Evanston, Ill. will now be known as The Evans at Canal Shores, offering a connection to the namesake of the Evans Scholars Foundation, Chick Evans. The new golf course will re-open in 2025 with an upgraded par-60, 18-hole golf course, youth development training center and Western Golf Association Caddie Academy. Evans attended high school in Evanston and became a great amateur golfer. Instead of turning professional, Evans worked with the Western Golf Association to use the earnings from his golf career to establish the Evans Scholars Foundation in 1930. Wanakah Country Club in Hamburg, N.Y. recently hosted its ninth annual golf marathon. This year's event teed off at 5:20 a.m. and included 28 players who played and walked 100 holes of golf in the one-day tournament. The event, known as “The Walk Fore Luca & Carly,” benefits Roswell Park's Courage of Carly Fund for programs supporting pediatric cancer patients and their families, and Live Like Luca, the Luca S. Calanni Foundation. A proposed short course at the Stanwich Club in Greenwich, Conn. and The Loop Golf Course in Chaska, Minn., showcase innovations that cater to diverse golfing needs and abilities. Stanwich Club's short course, named “The Cauldron,” offers a quicker game with about half the number of holes of a standard 18-hole course. This format is designed for those looking to improve their skills or enjoy a faster round of golf. The Loop Golf Course in Chaska, Minn. has emerged as a groundbreaking facility designed with wheelchair users in mind. This 9-hole, par-28 course, created through a partnership between the city of Chaska and Barrier Free Golf, eliminates traditional barriers such as sand traps and rough terrain to ensure accessibility for all players.

On this episode of The Fishbowl, host Chris Matheson and this week's guests, Dr. Sarah Pazur and Dr. Nick Orlowski dive into the complexities of America's educational landscape. Together, they dissect a thought-provoking article from the Wall Street Journal titled "America Has Too Many Schools." In this captivating conversation, Dr. Pazur and Dr. Orlowski, each bringing their unique perspectives, delve into the advantages and drawbacks of both large-scale educational institutions and smaller, more intimate settings. Their insightful analysis sheds light on the factors contributing to declining enrollment rates and the potential ramifications for the future of education in the United States. Tune in and join the conversation in The Fishbowl!  

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Orlowski, Corinne www.deutschlandfunkkultur.de, Lesart

Die Schriftstellerin Jenny Erpenbeck ist mit ihrem 2021 erschienen Buch "Kairos" für den International Booker Prize nominiert. Im Ausland wird ihr literarisches Werk allerdings mehr gefeiert als in Deutschland. Orlowski, Corinne www.deutschlandfunkkultur.de, Fazit

Adelphi University students, Jada and Cassie speak about the positives and negatives of different platforms of social media in the lives of its users. This discussion addresses the argument of social media's potential to be an addiction versus a distraction and the impact it has on students' lives inside and outside of the classroom. What can teachers do to help in strengthening their students' knowledge of social media? How can parents assist their children in navigating social media in a safe and responsible way? What can we do to be sensible users? These questions, and more, are discussed in this week's episode ‘Social Media Users' Status: Feeling Conflicted.'ReferencesGottfried, J. (2024, January 31). Americans' social media use. Pew Research Center. https://www.pewresearch.org/internet/2024/01/31/americans-social-media-use/Orlowski, J. (Director). (2020). The Social Dilemma [Movie]. Netflix. https://www.netflix.com/watch/81254224Shearer, E. (2023, April 18). Podcasts as a source of news and information. Pew Research Center. https://www.pewresearch.org/journalism/2023/04/18/podcasts-as-a-source-of-news-and-information/ The Knowledge Project Podcast. (2021, February 16). How to get more done and avoid distractions: Nir Eyal. YouTube. https://youtu.be/1wW9Ouw4dCo?si=d0jlspI_c1J-y7l7Ünlüsoy, A., Leander, K. M., & de Haan, M. (2022). Rethinking sociocultural notions of learning in the digital era: Understanding the affordances of networked platforms. E-Learning and Digital Media, 19(1), 78–92. https://doi.org/10.1177/20427530211032302

Orlowski, Corinnewww.deutschlandfunkkultur.de, Lesart

Orlowski, Corinnewww.deutschlandfunkkultur.de, Lesart

The year 2024 brings new promise in multiple myeloma with a wide variety of treatment options avaiable for both newly diagnosed and relapsed/refractory patients. Learn about the progress being made and the very latest in determining risk at diagnosis, strategies for smoldering myeloma patients, optimal treatments for newly diagnosed patients, things to consider at first relapse and beyond. Dr. Robert Orlowski will review advances in CAR T therapies, bispecific antibodies, targeted therapies and combination approaches and clinical trials to watch as the research continues advancing at a rapid pace in myeloma.  Thanks to our episode sponsor, GSK. 

Welcome to the award-winning FCPA Compliance Report, the longest-running podcast in compliance. In this episode, Tom Fox welcomes Frank Orlowski. Frank Orlowski is a seasoned professional with a wealth of experience in managing emerging markets in the pharmaceutical industry, having spent over 25 years at Pfizer Pharmaceuticals. His extensive knowledge, particularly in South America, Middle East Asia, and Eastern Europe, where he faced difficulties in compliance, controls, and adhering to US accounting regulations, has shaped his perspective on managing emerging markets. Orlowski emphasizes the importance of understanding different cultures, regulations, and geopolitical issues when working in these markets. After retiring from Pfizer, he founded the Ation Advisory Group, where he leverages his expertise to assist companies in commercializing products in the life science industry. Join Tom Fox and Frank Orlowski on this episode of the FCPA Compliance Report podcast to gain more insights into managing emerging markets in the pharmaceutical industry. Key Highlights: Frank Orlowski's Global Financial Expertise Navigating Unique Obstacles in Emerging Markets Navigating Cultural Differences in Emerging Market Compliance Creative Employee Rewards and Engagement Strategies Enhancing Healthcare Through Medtech Innovations The Integrated Legal Division at Pfizer Resources: Frank Orlowski on LinkedIn Tom Fox Instagram Facebook YouTube Twitter LinkedIn Learn more about your ad choices. Visit megaphone.fm/adchoices

By Adam Turteltaub When compliance professionals discuss AI most of the conversation tends to focus on the risk.  Frank Orlowski (LinkedIn), Founder and President of Ation Advisory Group, though, is far from all gloom and doom on the topic. In fact, he believes AI can be an asset to compliance programs. AI, he explains, can be of great value for compliance any place where there are large amounts of transactions that need to be monitored and checked. Two notable examples are travel & entertainment and accounts payable/vendors. AI is very useful for identifying outlier transactions that could be a sign of trouble. In manufacturing, it can be very helpful in monitoring materials being used. AI can also be helpful, he believes, in ESG efforts. But, there are limits. AI is not ready for handling contracts, he argues. It is also chronically deficient when it comes to addressing the gray areas of ethics and fairness. There it's important for compliance teams to work with the business unit closely to ensure decisions are adequately documented and AI does not make decisions that would be regrettable from an ethics perspective. Listen in to learn more about how AI could help your compliance efforts.

Would you rather live in a better world or a happier one? In this video we are going to explore how equality has made the world a better place but also how, like the Edenic apple of knowledge, it has come with a cost. The world looks better from the outside but seen from the subjective side it seems that things have only gotten worse. This is following up on the recent episode on Nietzsche's concept of ressentiment that we examined in the previous episodes and follows along our explorations in to the social and political radical theme of modern times. ____________________

In this episode, Lisa, Rebecca, David, and Becky discuss:A critique of the information and misinformation of the latest NACAC Annual Survey of Colleges. The role of ACT and SAT scores even beyond the admissions process. The impact of Institutional Priorities in the admission of students.Colleges have differing expectations for various majors, including highly competitive majors. Whether the ability to pay affects students' admission rates.Key Takeaways: To understand what schools seek for admissions, the common data set is more important than the NACAC survey for the colleges your student is considering.The survey does not reflect admission by major but is critical for your student to understand.College is more than just getting in; it is also about affording college. Test-optional admissions help the most wealthy students and the least wealthy students. It hurts those in the middle class the most. Institutional priorities, like the ability to pay, influence admission but are not covered in the survey. “We always have to take these surveys with a grain of salt. I encourage families to do their homework, to work with professionals, or to work closely with their school counselor to really understand the nuances of college admissions because until things change, it continues to be very opaque.” – Rebecca Stuart-OrlowskiAbout Becky Priest: Becky Priest is the College Counselor at The Cambridge School, where she has overseen the design and build-out of their college counseling program. She also has over 20 years of college financial aid experience at all levels. She is currently serving on the Classic Learning Test's Board of Academic Advisors.About David Blobaum: David Blobaum is a nationally recognized expert on standardized exams and college admissions. He graduated from the University of Chicago with honors. He co-founded and runs 1Summit Prep and he is the Director of Outreach for the National Test Prep Association. About Rebecca Stuart-Orlowski: Rebecca Stuart-Orlowski has been an educational consultant specializing in profoundly gifted, 2E, advanced STEM, and homeschooled students for 11 years. She has a Specialized Certificate in College Counseling, a BA in Communicative Disorders, and 2 teaching credentials, Multiple Subjects w/ a Multicultural Emphasis & Communicatively Handicapped. She taught deaf, deaf/blind, LD, and 2E students for 4 years. She's a member of IECA, cochair of the IECA Homeschool Affinity Group, and a member of NACAC and WACAC. Get Lisa's Free on-demand video: How-to guide for your teen to choose the right major, college, & career...(without painting themselves into a corner, missing crucial deadlines, or risking choices you both regret). flourishcoachingco.com/videoConnect with Rebecca:Facebook: facebook.com/OrlowskiCollegeConsulting LinkedIn: linkedin.com/in/rebeccastuartorlowskiEmail: r.orlowski.consulting@gmail.com Connect with David:Website: davidblobaum.comLinkedIn: linkedin.com/in/david-blobaum/X: twitter.com/David_Blobaum Connect with Becky:LinkedIn: linkedin.com/in/becky-priest-458b204b Website: cambridgeclassical.org Connect with Lisa:Website: https://www.flourishcoachingco.com/YouTube: https://www.youtube.com/@flourishcoachingcoInstagram: https://www.instagram.com/flourishcoachingco/LinkedIn: https://www.linkedin.com/company/flourish-coaching-co

In this enlightening episode, we are joined by Sven Orlowski, the Managing Director at EWE TRADING GmbH. EWE TRADING stands at the forefront of energy trading, interfacing the EWE Group's energy portfolio with the wholesale markets, and specializing in electricity and natural gas, emissions rights (EUA and CER), and oil and gas price hedging. We delve deep into the company's operations under Sven's leadership, discussing their unique approach to harmonizing and streamlining vast energy resources through sophisticated data strategies. Sven also offers an inside look at how modern data analytics tools are leveraged to optimize portfolio and accounting grid management, providing a comprehensive range of services to clients and partners.A significant portion of our conversation focuses on EWE TRADING GmbH's role as a leading market partner for renewable energy in Germany. Sven shares insights on how data analytics plays a crucial role in supporting operators of wind and solar parks nationwide in marketing their energy, paving the way for a sustainable future. This episode not only uncovers the fascinating intersection of energy trading and data analytics but also explores the future of renewable energy sources in Germany and beyond. Join us on this journey as we navigate the evolving landscape of energy trading and data management, capturing insights from one of the sector's leading figures.

Is it really challenging for homeschooled students to get admitted to college? Regardless of whether the student attended a public, private, or homeschool, as long as they have strong communication skills, the student will be fine. In this episode, Rebecca Stuart-Orlowski shares how to positively present homeschooled students through the college application process. HIGHLIGHTS:Strong communication skills by both the parent and student are essential for homeschooled familiesHow to overcome barriers for homeschooled students applying to collegeSpecial considerations in the college application process for homeschool families Advice for college-bound homeschools families around test-optional policiesWhat families with 10th and 11th graders can do to make the future application process easier Meet Our GuestRebecca Stuart-Orlowski has a Specialized Certificate in College Counseling from UCSD, a BA in Communicative Disorders from SDSU, and two active teaching credentials: Multiple Subjects w/ a Multicultural Emphasis and Communicatively Handicapped. She taught deaf, deaf/blind, LD, and twice-exceptional students for four years in Chula Vista and San Diego, and was an educational consultant for a small private Catholic PSP (Private Satellite Program) for three years. She has been an IEC since August 2012. Long before Rebecca moved into her career as an IEC, she was honing her communication skills that currently serve her so well. Rebecca performed professionally as a jazz dancer for over 20 years for the likes of The Beach Boys, Bill Gates and Microsoft, and Visionary Dance Theatre, where she was a choreographer, teacher, and soloist. Her final choreographic piece can be found here: https://www.youtube.com/watch?v=AJ85xnwK0as  Performing and interacting with professionals from all backgrounds lends itself well to her job as an IEC. Rebecca is a professional member of IECA, co-chair of the IECA Homeschool Affinity Group, and a member of NACAC and WACAC. She is the parent of two Davidson Young Scholar Alums and presented at a Davidson Young Scholar Summit on 2E children in 2021. Each fall, she speaks to homeschoolers and their parents on the topic of homeschooling and college admissions for her local homeschool co-op. She has been independently homeschooling for 25 years and will graduate with her third and last child in June 2023.  She specializes in gifted/2E, STEM, creative, homeschooled, and transfer students. Listen on…the Flourish Site, Spotify, Apple, Google, Amazon Music, Stitcher, or your favorite platform. “College & Career Clarity with Lisa is so helpful!”  ← Is that you? If so, please consider rating and Connect with Lisa: Website: https://www.flourishcoachingco.com/ YouTube: https://www.youtube.com/@flourishcoachingco Instagram: https://www.instagram.com/flourishcoachingco/ Facebook: https://www.facebook.com/flourishcoachingco LinkedIn: https://www.linkedin.com/in/lisa-marker-robbins/

Andrew Orlowski joins Snowdon and Slater to discuss the idiocy of our green elites, the rise and fall of FTX, and the cult of booze prohibition. Become a spiked supporter: https://www.spiked-online.com/supporters/  Sign up to spiked's newsletters: https://www.spiked-online.com/newsletters/ Check out spiked's shop: https://www.spiked-online.com/shop/  Send your postbag questions to lastorders@spiked-online.com and we'll try to answer them in the next episode.

There are significant advances being made in multiple myeloma and more so than in any other cancer. Join us for this annual show with Robert Orlowski, MD, PhD as we discuss the recent findings from the American Society of Hematology (ASH) meeting, key innovations being developed in myeloma and what patients can expect to see in 2023. The show will review immunotherapy options, optimal combination therapies, targeted treatments and key learnings from top myeloma investigators.   Thanks to our episode sponsor, GSK

Status Epilepticus is one of the most common pediatric neurologic emergencies and requires prompt, targeted treatment to reduce patient morbidity and mortality. On this podcast, Pediatric Critical Care Physician, Dr. Renuka Mehta, Pediatric Resident Physician, Dr. Yvonne Ibe, and medical student, Emily Austin will discuss management for status epilepticus and rapid interventions that can be potentially lifesaving—because in seizure management, time is brain.  FREE CME Credit (requires sign-in):  Link Coming Soon! Thank you for listening to this episode from the Department of Pediatrics at the Medical College of Georgia. An additional thanks to Dr. Lorna Bell, Dr. George Hsu, and Dr. Rebecca Yang who provided editing and peer review of today's discussion. If you have any comments, suggestions, or feedback- you can email us at mcgpediatricpodcast@augusta.edu Remember that all content during this episode is intended for educational purposes only. It should not be used as medical advice to diagnose or treat any particular patient. Clinical vignette cases presented are based on hypothetical patient scenarios. Thank you for your support! References: Alldredge, B. K., Gelb, A. M., Isaacs, S. M., Corry, M. D., Allen, F., Ulrich, S., Gottwald, M. D., O'Neil, N., Neuhaus, J. M., Segal, M. R., & Lowenstein, D. H. (2001). A Comparison of Lorazepam, Diazepam, and Placebo for the Treatment of Out-of-Hospital Status Epilepticus. New England Journal of Medicine, 345(9), 631–637. https://doi.org/10.1056/NEJMoa002141  Chamberlain, J. M., Kapur, J., Shinnar, S., Elm, J., Holsti, M., Babcock, L., Rogers, A., Barsan, W., Cloyd, J., Lowenstein, D., Bleck, T. P., Conwit, R., Meinzer, C., Cock, H., Fountain, N. B., Underwood, E., Connor, J. T., Silbergleit, R., Neurological Emergencies Treatment Trials, & Pediatric Emergency Care Applied Research Network investigators. (2020). Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial. Lancet (London, England), 395(10231), 1217–1224. https://doi.org/10.1016/S0140-6736(20)30611-5  Chamberlain, J. M., Okada, P., Holsti, M., Mahajan, P., Brown, K. M., Vance, C., Gonzalez, V., Lichenstein, R., Stanley, R., Brousseau, D. C., Grubenhoff, J., Zemek, R., Johnson, D. W., Clemons, T. E., & Baren, J. (2014). Lorazepam vs Diazepam for Pediatric Status Epilepticus: A Randomized Clinical Trial. JAMA, 311(16), 1652. https://doi.org/10.1001/jama.2014.2625  Chen, J., Xie, L., Hu, Y., Lan, X., & Jiang, L. (2018). Nonconvulsive status epilepticus after cessation of convulsive status epilepticus in pediatric intensive care unit patients. Epilepsy & Behavior: E&B, 82, 68–73. https://doi.org/10.1016/j.yebeh.2018.02.008  Fine, A., & Wirrell, E. C. (2020). Seizures in Children. Pediatrics in Review, 41(7), 321–347. https://doi.org/10.1542/pir.2019-0134  Glauser, T., Shinnar, S., Gloss, D., Alldredge, B., Arya, R., Bainbridge, J., Bare, M., Bleck, T., Dodson, W. E., Garrity, L., Jagoda, A., Lowenstein, D., Pellock, J., Riviello, J., Sloan, E., & Treiman, D. M. (2016). Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society. Epilepsy Currents, 16(1), 48–61. https://doi.org/10.5698/1535-7597-16.1.48  Hanhan, U. A., Fiallos, M. R., & Orlowski, J. P. (2001). Status epilepticus. Pediatric Clinics of North America, 48(3), 683–694. https://doi.org/10.1016/s0031-3955(05)70334-5  Kapur, J., Elm, J., Chamberlain, J. M., Barsan, W., Cloyd, J., Lowenstein, D., Shinnar, S., Conwit, R., Meinzer, C., Cock, H., Fountain, N., Connor, J. T., Silbergleit, R., & NETT and PECARN Investigators. (2019). Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. The New England Journal of Medicine, 381(22), 2103–2113. https://doi.org/10.1056/NEJMoa1905795  Lyttle, M. D., Rainford, N. E. A., Gamble, C., Messahel, S., Humphreys, A., Hickey, H., Woolfall, K., Roper, L., Noblet, J., Lee, E. D., Potter, S., Tate, P., Iyer, A., Evans, V., Appleton, R. E., Pereira, M., Hardwick, S., Messahel, S., Noblet, J., … Hobden, G. (2019). Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. The Lancet, 393(10186), 2125–2134. https://doi.org/10.1016/S0140-6736(19)30724-X  Raspall‐Chaure, M., Chin, R. F. M., Neville, B. G., Bedford, H., & Scott, R. C. (2007). The Epidemiology of Convulsive Status Epilepticus in Children: A Critical Review. Epilepsia, 48(9), 1652–1663. https://doi.org/https://doi.org/10.1111/j.1528-1167.2007.01175.x  Riviello, J. J., Ashwal, S., Hirtz, D., Glauser, T., Ballaban-Gil, K., Kelley, K., Morton, L. D., Phillips, S., Sloan, E., Shinnar, S., American Academy of Neurology Subcommittee, & Practice Committee of the Child Neurology Society. (2006). Practice parameter: diagnostic assessment of the child with status epilepticus (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology, 67(9), 1542–1550. https://doi.org/10.1212/01.wnl.0000243197.05519.3d  Sánchez Fernández, I., Abend, N. S., Agadi, S., An, S., Arya, R., Brenton, J. N., Carpenter, J. L., Chapman, K. E., Gaillard, W. D., Glauser, T. A., Goodkin, H. P., Kapur, K., Mikati, M. A., Peariso, K., Ream, M., Riviello, J., Tasker, R. C., & Loddenkemper, T. (2015). Time from convulsive status epilepticus onset to anticonvulsant administration in children. Neurology, 84(23), 2304–2311. https://doi.org/10.1212/WNL.0000000000001673  Trinka, E., Cock, H., Hesdorffer, D., Rossetti, A. O., Scheffer, I. E., Shinnar, S., Shorvon, S., & Lowenstein, D. H. (2015). A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia, 56(10), 1515–1523. https://doi.org/10.1111/epi.13121  Welch, R. D., Nicholas, K., Durkalski-Mauldin, V. L., Lowenstein, D. H., Conwit, R., Mahajan, P. V., Lewandowski, C., Silbergleit, R., & Neurological Emergencies Treatment Trials (NETT) Network Investigators. (2015). Intramuscular midazolam versus intravenous lorazepam for the prehospital treatment of status epilepticus in the pediatric population. Epilepsia, 56(2), 254–262. https://doi.org/10.1111/epi.12905 

Featuring perspectives from Drs Jesús Berdeja, Rafael Fonseca, Sagar Lonial, Robert Orlowski and Noopur Raje, including the following topics: Front-Line Treatment of Multiple Myeloma (MM)  Introduction (0:00) Case: A woman in her early 50s with newly diagnosed MM (NDMM) and 1q gain who presents with a pathologic fracture and receives daratumumab/RVd — Bhavana (Tina) Bhatnagar, DO (2:49) Cases: An otherwise healthy man in his late 80s with NDMM who is disinclined to undergo aggressive therapy and a transplant-ineligible woman in her late 70s with NDMM — Erik Rupard, MD and Hans Lee, MD (10:05) Dr Orlowski presentation (15:45) Integration of Novel Therapies into the Management of Relapsed/Refractory MM  Cases: A transplant-eligible man in his late 60s with well-controlled HIV-1 and standard-risk NDMM and a man in his late 60s with high-risk, t(4;14) multiregimen-refractory MM with travel limitations who receives belantamab mafodotin — Neil Morganstein, MD and Syed Farhan Zafar, MD (29:19) Cases: A woman in her early 70s who receives daratumumab, bortezomib and dexamethasone for relapsed MM 6 years after RVd followed by autologous stem cell transplant and maintenance bortezomib, and a man in his mid 50s with NDMM who received RVd followed by maintenance lenalidomide, which was discontinued by the patient after 1 year — Henna Malik, MD and Dr Rupard (35:50) Dr Fonseca presentation (41:57) Current Role of Chimeric Antigen Receptor (CAR) T-Cell Therapy for MM  Case: A man in his early 70s with NDMM who receives induction daratumumab/RVd — Spencer H Bachow, MD (52:27) Cases: A woman in her early 60s with relapsed MM and pathologic fractures who received induction daratumumab/Rd and palliative radiation therapy for bone disease, and a woman in her mid 70s with refractory MM 6 months after induction daratumumab/RVd lite — Dr Bhatnagar and Kimberly Ku, MD (57:00) Dr Raje presentation (1:01:12) Bispecific Antibodies in the Treatment of MM  Case: A man in his early 70s with t(4;14) NDMM who initiates RVd, which is put on hold to treat severe depression — Warren S Brenner, MD (1:14:38) Case: A woman in her mid 70s with multiregimen-refractory del(17p) MM who is considered for BCMA-directed therapy — Dr Bachow (1:16:28) Dr Berdeja presentation (1:22:18) Other Investigational Novel Agents for MM  Case: A woman in her mid 80s with congestive heart failure and t(4;14), t(11;14) and t(14;16) MM who receives dose-reduced RVd and develops chalazion eye toxicity — Jennifer L Dallas, MD (1:36:23) Dr Lonial presentation (1:39:34) CME information and select publications

Michal chats about his last few weeks away in the USA, and of course the new L1R from Schumacher

Pour ce nouvel épisode de Chiffon, je vous invite à pousser les portes de Collector Square avec sa co fondatrice Osanna Orlowsky. Collector Square est la référence en matière de revente d'accessoires de luxe véritable "caverne d'Ali Baba" pour toutes les "modeuses" dignes de ce nom.Sa co fondatrice, issu du monde de l'art, a accepté de me recevoir dans son bureau, boulevard Raspail dans le 7ème arrondissement de Paris. Avec elle, nous avons échangé sur les débuts de Collector Square, sur son fonctionnement, sur le marché de la seconde main et... évidemment, nous avons parlé... mode ! Osanna est une femme qui ne se prend absolument pas la tête avec ses fringues. Ce qui la séduit ? Le détail. Sa définition de l'élégance ? "L'art du naturel". Tout est dit ! Bonne écoute !https://www.collectorsquare.com Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Pat Orlowski joins Zee and Justin to talk about all things Woodstock 99This Podcast is sponsored by - Upgrade Brain Formula- https://freemanformula.com/*use promo code: disruption for a 15% discount *EJA Moving Service- www.ejamoving.comJoey's at 307- www.315eats.comBallsy- www.ballwash.com *Use Promo Code MEMEBERSONLY for 15% discount *Utica Coffee Roasters- www.wakethehellup.comSaranac Brewery- www.saranac.comAttorney Dave Longeretta- 315-735-6162___________________________________________________________________________________________________________Support this podcast through Virtual Tip Jar- Venmo: @xytoda Cash App: https://cash.app/AnthonyZeeDonaldson____________________________________________________________________________________________________________Get Social with The D-The D on Facebook- https://www.facebook.com/DisruptionnetworkThe D on Instagram- https://www.instagram.com/disruptionnetwork/The D on Twitter - https://twitter.com/the_D_networkThe D on YouTube- https://www.youtube.com/disruptionnetworkThe D on Twitch- https://www.twitch.tv/disruptionnetwork

Live from Vienna, Michal talks us through his double win at the UK nationals