Podcast appearances and mentions of princess margaret

Happy Thursday! Jane and Fi muse over the duality of the cake slicer, imagine a youthful Jane clasping her briefcase and a Flemish train map, and consider the effectiveness of a silent siren. Plus, Princess Margaret's former lady-in-waiting Lady Glenconner discusses her latest book ‘Manners and Mischief'. We've announced our next book club pick! 'Just Kids' is by Patti Smith. You can listen to the playlist here: https://open.spotify.com/playlist/3qIjhtS9sprg864IXC96he?si=uOzz4UYZRc2nFOP8FV_1jg&pi=BGoacntaS_uki.If you want to contact the show to ask a question and get involved in the conversation then please email us: janeandfi@times.radioFollow us on Instagram! @janeandfiPodcast Producer: Eve SalusburyExecutive Producer: Rosie Cutler Hosted on Acast. See acast.com/privacy for more information.

Princess Margaret, Prince Andrew, and Prince Harry were all born Spares to the Heirs, however, unlike the Spares before him, Prince Harry did not allow the Monarchy to define and choose his purpose in life. Prince Harry always knew that he was destined to be greater than a Spare, and the Monarchy did too. Support the show"You need to know that you're enough" Meghan, Duchess of Sussexhttps://twitter.com/meghan_worldhttps://podcasts.apple.com/podcast/id1592779000https://paypal.me/duchessofadvocacyhttps://www.buymeacoffee.com/duchessmeghan

Three generations of Royals have brutally frozen out their own siblings - Elizabeth, William and now Charles, who’s buckled to pressure from the Prince and Princess of Wales to strip Prince Andrew of his title.See omnystudio.com/listener for privacy information.

Divorce, contrary to what many believe, was not permitted by the Church of England. Henry VIII didn't divorce two wives, he had the marriages annulled, declaring in effect that they'd never happened. The Church itself remained as opposed to divorce as the Catholics. That's why Edward VIII had abdicated in the 1930s, so he could marry the divorcee he loved. It's also why Queen Elizabeth II, as head of the Church of England – just as Henry VIII had been – forbade her sister Princess Margaret's marriage to a divorcee, a decision that blackened the rest of Margaret's life.That's why it's such an irony that three of Elizabeth's four children had marriages that led to divorce. Indeed, her eldest son Charles, now king himself and head of the Church, not only divorced his wife, Princess Diana, but married the love of his life, Camilla, herself divorced and happily settled as queen.His strained marriage and ultimate divorce caused great pain to Diana. That led to her rather wild last years, culminating in the terrible car crash in Paris that caused her death. That turned into a real crisis for the British monarchy, when the queen and royal family reacted with apparently complete tone deafness to the sorrow that swept across Britain and indeed into other countries too. It was a crisis from which the Blair government helped the monarchy emerge and get back to on the road to a return to its traditional popularity, which enjoys again today.Just as he helped modernise, a very little, one traditional British institution, Blair also worked on another, the British army. He adopted what he called an ethical foreign policy but his foreign secretary, Robin Cook, referred to less ambitiously as a foreign policy with an ethical dimension. The way it worked was shown in the NATO operation in Kosovo, presented by its supporters as essentially a humanitarian mission, though its detractors wouldn't agree.What the operation certainly did do, however, was provide a telling example of the principle that military men sometimes achieve their goals most effectively by not opening fire, rather than provoking a violent confrontation. That's a great story, well worth the telling. Illustration: Diana, the people's princess. Photo credit: Ron Sachs/picture-alliance/Cover ImagesMusic: Bach Partita #2c by J Bu licensed under an Attribution-NonCommercial-No Derivatives (aka Music Sharing) 3.0 International License

Princess Margaret, Countess of Snowdon was a bright rose, who bloomed even in the shadow of her older sister, Queen Elizabeth II. She was a fashion icon and the life of many parties. She had a scandalous romance her sovereign sibling could never sanction, and a disastrous marriage which paved the way for future royal divorces. And through it all, she was a dedicated support and friend to the Queen. Let's peek behind the tabloid headlines and the outrageous scenes in the Crown, and get to know the real Princess Margaret. Join me every Tuesday when I'm Spilling the Tea on History! Check out my Youtube Channel: https://www.youtube.com/c/lindsayholiday Follow me on Facebook: https://www.facebook.com/profile.php?id=100091781568503 Instagram: https://www.instagram.com/historyteatimelindsayholiday/ Tik Tok: https://www.tiktok.com/@historyteatime Please consider supporting me at https://www.patreon.com/LindsayHoliday and help me make more fascinating episodes! Intro Music: Baroque Coffee House by Doug Maxwell Music: Brandenburg Concerto No4-1 BWV1049 - Classical Whimsical by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ Source: http://incompetech.com/music/royalty-free/index.html?isrc=USUAN1100303 Artist: http://incompetech.com/ #HistoryTeaTime #LindsayHoliday Please contact ⁠advertising@airwavemedia.com⁠ if you would like to advertise on this podcast. Learn more about your ad choices. Visit megaphone.fm/adchoices

New Edition available here. 'A fascinating, tragic and instructive story, vividly told' Sunday TelegraphRoger Lewis, in his no-holds-barred biography, exposes a Peter Sellers the world little knows. Recognized as the greatest British comic since Charlie Chaplin, Sellers was the grand master of fifty-five films - from Dr. Strangelove, to Being There and the Pink Panther hits.But shadowing his phenomenal career was a history of increasingly bizarre behaviour involving psychotic violence, compulsive promiscuity, drug abuse and humiliating self-destructive obsessions with people including Princess Margaret, Sophia Loren, Liza Minnelli and each of his four wives (Ann Hayes, Britt Ekland, Miranda Quarry and Lynne Frederick). He alternately showered his wives and children with gifts and then threatened to kill them. Sellers' fluidity as an actor made for a terrifying madness that grew like a slow metastasizing cancer throughout his adult life.The Life and Death of Peter Sellers concludes with his premature death at the age of 54, 'sick at heart and alone in those sunless hotel rooms', so recoiled from intimacy that no one really knew him anymore. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Coldstream Guards surprise royal watchers by playing Black Sabbath's Paranoid outside Buckingham Palace as fans honour Ozzy Osbourne. We dig into claims that Princess Margaret had fetal alcohol syndrome — and why royal friends are calling that “ridiculous.” Plus: King Charles may be hiding out at the Castle of Mey, Windsor Castle hosts an iftar, Sophie skips Diana's funeral, Meghan Markle's rosé returns, tsunami alerts near Montecito, and could your surname reveal royal roots?Follow our new series Crown and Controversy! Follow now. The full Season 1 is available now for premium subscribers. Episodes come out every Sunday on the normal feed.To become a premium subscriber (no ads and no feed drops) visit caloroga.com/plus. For Apple users, hit the banner on your Apple podcasts app which says UNINTERRUPTED LISTENING.

For over 40 years, Helena Bonham Carter has delighted us with roles including Lucy Honeychurch in Room with a View, Princess Margaret in The Crown and Harry Potter's much-loved villain, Bellatrix Lestrange. She joined Nuala McGovern to discuss her latest role in new film, Four Letters of Love, based on the bestselling book of the same name. Eight babies have been born in the UK using genetic material from three people to prevent devastating and often fatal conditions. The method, pioneered by UK scientists, combines the egg and sperm from a mum and dad with a second egg from a donor woman. The technique has been legal in the UK for a decade but this is the first proof it is leading to children born free of incurable mitochondrial disease, which is normally passed from mother to child. Anita Rani was joined by Kat Kitto who has two daughters, one of whom has mitochondrial disease, and Louise Hyslop, consultant embryologist at the Newcastle Fertility Centre to discuss.A new report by London's Victims' Commissioner, Claire Waxman, says that victims are being forced to quit the criminal justice system in huge numbers amid record court delays and traumatic process. She joined Nuala to explain why they are saying 'there is a near total failure in seeing offenders brought to justice', especially when it comes to female victims of violence. In the second part of our series about women and gaming, we find out more about the impact gaming can have on women's lives. Nuala heads to the Virgin Media Gamepad at the O2 to meet some of the women from the Black Girl Gamers community, who have over 10,000 members around the world. The bestselling author Louise Candlish joined Anita to talk about her latest novel - A Neighbour's Guide to Murder - which explores the practice of sex for rent and a trial by social media. The American jazz singer Samara Joy has five Grammy awards to her name and is quickly gaining superstar status in the jazz world. She is making her debut at the BBC Proms tonight, where she will be backed by the BBC Concert Orchestra, in a special tribute to the Great American Songbook. The Prom will be also be live on Radio 3, on BBC Four and iPlayer.Presenter: Anita Rani Producer: Annette Wells Editor: Deiniol Buxton

Last night England faced Wales in their final match of the group stage of the UEFA Women's Euro and England came out victorious - winning 6-1 and knocking Wales out of the tournament in the process. To discuss the result, Nuala McGovern is joined by England's top goal scorer and former Lioness Ellen White, and Laura McAllister, Vice-President of UEFA, who was previously the captain of Wales' women's team, gaining 24 caps for her country. For over 40 years, Helena Bonham Carter has delighted us with roles including Lucy Honeychurch in Room with a View, Princess Margaret in The Crown and Harry Potter's much-loved villain, Bellatrix Lestrange. She joins Nuala in the studio to discuss her latest role in new film, Four Letters of Love. Based on the bestselling book of the same name, she plays Margaret Gore, the wife of a poet living on a remote island in the West of Ireland in the 1970s. We bring you the latest on the excavation of a mass grave of babies and young children at Tuam in County Galway in Ireland, due to begin later today. The exhumations will be carried out at the site of an institution for unmarried mothers, which operated between 1925 and 1961. We speak to journalist Alison O'Reilly, one of the women who pushed to get this investigation underway. All this week we're taking a deep dive into the world of gaming. It's an industry worth £6bn - more than music, TV and film combined - so we'll be exploring what impact it has on our lives (whether we realise it or not) and where women come into it. First up, we're joined by video game reporter and eSports presenter Frankie Ward and Twitch streamer Alyce, also known online as Alyska Plays, to discuss. Presenter: Nuala McGovern Producer: Sarah Jane Griffiths

This is a personal post and my first post with a request. My wife, life partner and business partner, Ann Hetram, passed away unexpectedly from cancer 2 months ago.  She received excellent care at Princess Margaret Hospital, which is the best cancer hospital in Canada. In her honour, I am co-captain of a team in the Journey to Conquer Cancer walk to support research at Princess Margaret Hospital.  My team is the Harbour Square Team for my condo building. The walk is on Sunday, June 15 at 9 AM. It starts at the University of Toronto, Varsity Stadium, 299 Bloor Street West, Toronto. Donations support breakthrough research, supporting over 1,600 researchers and scientists working on innovative projects, such as early detection methods, personalized cancer treatments, and immunotherapy advancements. Ann's cancer was classified as an “unknown tumor”. She received a personalized cancer treatment including immunotherapy. I'm hopeful that with your support, research will advance to help others facing rare cancers like hers. Whether you walk with us, join virtually, or donate — every step and every dollar counts. Thank you, Ed  

A chaotic, shambolic and critically panned parody, the first on-screen incarnation of Ian Fleming's novel ‘Casino Royale' received its London premiere on 12th April, 1967 - with final edits still being made in the projection room. Nonetheless, it went on to take an extraordinary $40 million at the box office.  Hardnut hero James Bond's adventures had become a swinging Sixties sex comedy starring Peter Sellers, thanks to Fleming's disasterous decision to sell the movie rights to actor Gregory Ratoff for a song long before Bond was known all around the world thanks to the highly succesful film versions of his later books ‘Dr No' and ‘From Russia With Love'. In this episode, Arion, Rebecca and Olly reveal how producer Charles K Feldman assembled such an impressive cast list for his 007 ensemble, including Orson Welles, Ronnie Corbett and Ursula Andress; explain how an on-set visit by Princess Margaret prompted an enormous clash of egos; and ponder why ‘the Spice World of the Sixties' became such a box office hit…  Further Reading: • ‘Casino Royale movie review & film summary' (Roger Ebert, 1967): https://www.rogerebert.com/reviews/casino-royale-1967 • ‘The Casino Royale calamity: how Peter Sellers turned Bond into a laughing stock' (Daily Telegraph, 2021): https://www.telegraph.co.uk/films/0/casino-royale-calamity-peter-sellers-turned-bond-laughing-stock/ • ‘Casino Royale: Official Trailer' (MGM, 1967): https://www.youtube.com/watch?v=onhWav2DejM Love the show? Support us!  Join 

In the early days of the P2P industry, most nonprofits concentrated on one tentpole P2P event—typically a walk or cycling program—which allowed them to align staffing, branding, and resources around a single, large-scale initiative, focusing on broad market appeal. However, as the industry has evolved, so too has the need to diversify offerings—both to engage new audiences and to meet the changing expectations of existing supporters. Expanding into new events definitely comes with its own set of challenges—especially without a clear plan—but it also opens the door to exciting opportunities. With strong internal alignment, consistent branding, and a collaborative approach, building out a mix of P2P campaigns can spark innovation, boost engagement, and drive real growth.In this episode, P2PPF's Marcie Maxwell is joined by Steve Merker, VP of Corporate and Community Partnerships at the Princess Margaret Cancer Foundation, Canada's leading cancer fundraising organization, which was recently recognized as the 2025 Peer-to-Peer Professional Forum Organization Of The Year.  They explore how Princess Margaret expanded its peer-to-peer portfolio from two events to eight, the growing pains and opportunities that come with that kind of scale, and how collaboration, brand clarity and a strategic mindset have fueled their success.In this episode, we'll also explore:Smart strategies for expanding your P2P event lineup without cannibalizing your audienceHow to foster internal alignment and reduce “turf wars” as your portfolio growsWays to create synergy across events while keeping each program's identity strongMentioned LinksRide to Conquer CancerWalk to Conquer CancerRoad Hockey to Conquer CancerJourney to Conquer CancerNorthern Pass to Conquer CancerCricket to Conquer CancerStay Connected on LinkedInConnect with SteveConnect with MarcieConnect with the Peer-to-Peer Professional Forum (00:00) - Welcome to The P2P Soap Box (01:38) - Introducing Steve Merker (07:49) - The Spark of Expansion (11:38) - Navigating Challenges of Event Cross-over (16:13) - Branding (20:13) - Managing Complex Teams (22:56) - Advice for Growth (26:58) - Learn More

Pour yourself a gin, pop on your pearls, and dust off your stiff upper lip as hosts Gráinne Maguire and Chantal Feduchin-Pate peer behind the velvet curtains of royal heartbreak in this special episode of The Way They Were. Joining them for a jolly good gossip is comedian, author, and undisputed queen of feminist history books, Eleanor Morton. Together, they'll dissect the delightfully doomed romance between the original royal rebel, Princess Margaret, and the roguishly charming Lord Snowdon. Expect scandalous insights into swinging sixties soirées, a sassy photographer called Cecil and the worst love notes of all time. Buckle up, dear listeners; it's a right royal affair! Learn more about your ad choices. Visit megaphone.fm/adchoices

Prue Leith reveals her kitchen secrets, discloses how she won her Michelin star, describes the twin disasters of pouring tea for the Queen and setting the kitchen on fire while cooking for Princess Margaret, tells the story of what happened when the Beatles ate at her restaurant, announces her favourite chef, spells out why she's not a food snob, discusses finding love again in her seventies, lets us in on the secret to her happy marriage with John (now her co-star on Prue Leith's Cotswold Kitchen), takes us behind the scenes on The Great British Bakeoff, explains her support for assisted dying, and recounts the time she had breakfast with Winston Churchill. 

Book Club #129 - A Voyage Around The Queen - Richard talks to journalist Craig Brown about his fantastic biography of Queen Elizabeth II, A Voyage Around the Queen. They discuss his glorious tangential approach to biography which he's already used to great effect in books on Princess Margaret and the Beatles, how the Queen in an alternate universe might have been a more anonymous figure, how she had been there through almost all of our lives, the occasionally excretory effect she had on people how met her, whether it's possible to grasp her real character, the profundity of people queuing to see her lying in state, the possible truth about Michael Fagan and how Rich might have figured in the book had he been a little braver. Plus how Royal protocol resulted in Cherie Blair getting pregnant, how Craig upset Donald Trump and the wrong uns that drifted through the Queen's life.Buy the book here - https://www.amazon.co.uk/Voyage-Around-Queen-bestselling-biography/dp/0008557497Come to a RHLSTP live! - https://richardherring.com/rhlstp Become a member at https://plus.acast.com/s/rhlstp. Hosted on Acast. See acast.com/privacy for more information.

A bit of a Christmas treat this… Zandra Rhodes is one of the most recognisable and influential figures in fashion, as well as the founder of the Fashion and Textile Museum in London. Describing herself as both ‘chaotic' and ‘fastidious', she possesses a unique sense of colour and pattern. Over the years, she has dressed some of the world's most famous people from Freddie Mercury, Elizabeth Taylor, Debbie Harry and Diana Ross to royals including Princess Anne, Princess Margaret and Princess Diana. She has also appeared on TV shows such as Absolutely Fabulous and Masterchef. Zandra was made a Dame in 2015, while this year, she published an intimate biography, entitled Iconic: My Life in Fashion in 50 Objects, which shines a light on an utterly extraordinary career. In this Yuletide episode, we talk about: Zandra's ‘more is more' home and studio at Christmas; the importance of working with your hands; festive fun with cult actor Divine; her collecting habit; becoming interested in textile design at art college; her love of drawing; nearly meeting Andy Warhol; why pink is a ‘complicated' colour; how print leads the garment in her work; breaking America; Lauren Bacall stepping on a pin in her studio;  working with the royal family and dressing Freddie Mercury; the influence of friendship and travel on her practice; dealing with cancer; and founding London's Fashion and Textile Museum.Support the show

JCO PO authors Dr. Philippe Bedard (Staff Medical Oncologist at Princess Margaret Cancer Centre and Professor of Medicine at University of Toronto) and Dr. Alberto Hernando Calvo (Medical Oncologist at Vall d´Hebron University Hospital) share insights into their JCO PO article, “Combined Transcriptome and Circulating Tumor DNA Longitudinal Biomarker Analysis Associates With Clinical Outcomes in Advanced Solid Tumors Treated With Pembrolizumab,” one of the top downloaded articles of 2024. Host Dr. Rafeh Naqash and Drs. Bedard and Hernando Calvo discuss how combined transcriptome and ctDNA longitudinal analysis associates with pembrolizumab outcomes. TRANSCRIPT Dr. Rafeh Naqash: Hello and welcome to JCO Precision Oncology Conversations where we bring you engaging conversations with authors of clinically relevant and highly significant JCO PO articles. I'm your host, Dr. Rafeh Naqash, podcast editor for JCO Precision Oncology and Assistant Professor at the OU Health Stephenson Cancer Center at the University of Oklahoma.  Today we are excited to be joined by Dr. Philippe Bedard, Staff Medical Oncologist at the Princess Margaret Cancer Center and Professor of Medicine at the University of Toronto, as well as by Dr. Alberto Hernando-Calvo, Medical Oncologist at the Vall d'Hebron University Hospital, both authors of the JCO Precision Oncology article titled, “Combined Transcriptome and Circulating Tumor DNA Longitudinal Biomarker Analysis Associates With Clinical Outcomes in Advanced Solid Tumors Treated With Pembrolizumab.”  Thank you for joining us today. Phil and Alberto. Dr. Alberto Hernando-Calvo: Thank you. Dr. Philippe Bedard: Great to be with you. Thanks for having us.  Dr. Rafeh Naqash: One of the reasons we do this podcast, as some of the listeners who listen to this podcast regularly may know, is to bring in novel approaches and try to understand how the field is moving towards a space where we are understanding biomarkers better. So your manuscript that was published in JCO Precision Oncology fulfills many of those criteria. And interestingly enough, I was at a conference at the Society for Immunotherapy of Cancer last month earlier in November and a lot of excitement at SITC was revolving around novel transcriptomic biomarkers, proteomic biomarkers or imaging based biomarkers. So could you tell us a little bit about why you started looking at biomarkers? This is an extremely competitive field. Why did you think that looking at the transcriptome is somewhat different from or more interesting from tumor mutational burden PDL-1 than other biomarkers that we currently use? And that question is for you Alberto to start off.  Dr. Alberto Hernando-Calvo: So I think gene expression profiles may have a predictive performance as compared to already existing biomarkers and this was one of the points that we describe in our manuscript. The gene expression signature that we developed back in 2019 at Vall d'Hebron Institute of Oncology was initially developed based on over 45 different tumor types and tested in over 1000 patients treated with antiPD-1 and anti PDL-1. And back then and in this manuscript, we proved that for instance the gene expression signature VIGex that we developed has a potential complementary role to other predictive biomarkers. In this case, we observe this predictive power with ctDNA dynamics and we then see a correlation with other existing biomarkers such as tumor mutational burden. So I don't think we need to use one or the other, but rather they may have additive predictive power. So we need to better individualize predictive biomarkers based on tumor types and select the best combination possible to improve the performance.  Dr. Rafeh Naqash: I completely agree that one size does not fit all, especially in the landscape of immunotherapy. From your perspective, when you developed the original signature, how did you choose what genes to look at? I looked at the manuscript, on the methodology side, some of the signatures are pro-inflammatory STING interferon gamma based, so how did you try to identify that these are the 7 to 10 or whatever number of signatures on the transcriptome side? And then why did you try to combine it with ctDNA based changes?  Dr. Alberto Hernando-Calvo: Back in our initial manuscript, published in Med from Cell Press, we developed the VIGex gene expression signature, as I mentioned, with taking into consideration over 1000 tumor samples from FFPE that we can consider real world samples because they are from real patients coming from the clinic notes as part of real investigational protocol doing or performing biopsies on patients. We did observe after doing a VIGex research and doing different tests, we eventually collected these 12 different genes. Because there is a combination of both genes involved in the interferon gamma pathway, we have genes associated with Tregs as well as T cell memory cells. So it's not only looking at genes that are associated with T cell activation or CD8+ T cell infiltration, but also looking at genes that may be overactivated, overexpressed, an immunosuppressive tumor microenvironment. So it was both selecting genes, the minimum number of genes to do it more scalable and having the minimum dataset of genes and including in the signature genes that are already at targets for immune sequent inhibitors or are being tested in immunotherapy combinations.  Dr. Rafeh Naqash: Thank you. And Phil, for the sake of our listeners, could you elaborate upon this aspect of using ctDNA? So this was tumor-informed ctDNA from what I understood in the manuscript. You guys basically try to use it to understand changes in the ctDNA with treatment and then try to combine it with the transcriptome signature. How did the idea come up initially and how did you plan on combining this with an RNA-based signature? Because I have seen manuscripts and other data where people are either using one or the other, but not necessarily both together. So how did you guys come up with that idea? Dr. Philippe Bedard: Well, we thought that this was a great opportunity to look at the combination of the transcriptome as well as the ctDNA dynamics because we had run an investigator-initiated phase 2 clinical trial called INSPIRE at our institution at Princess Margaret from 2016 to 2018, where patients across five different tumor groups received single agent pembrolizumab. And we really did a deep dive on these patients where there were tumor biopsies before and while on treatment. We did exome sequencing, we did RNA sequencing to capture the transcriptome. And in a prior analysis, we had partnered with Natera to look at their Signatera assay, which is a bespoke ctDNA assay, to look at ctDNA dynamics using this test and the association with response outcomes as well as survival outcomes. So we thought that this was a really unique data set to try and address the question of whether or not there was complementarity in terms of looking at the transcriptome and transcriptome signatures of IO benefit together with the ctDNA dynamics. Dr. Rafeh Naqash: From a patient treatment standpoint, it sounded like you mostly tried to include individuals who were treated with pembrolizumab. Did this not include individuals who were treated with chemoimmunotherapy or chemotherapy with pembrolizumab? Just pembrolizumab alone? And if that's the case, some of the tumor types there included, from what I remember, ovarian cancer and some other unusual cancers that don't necessarily have approvals for single agent pembrolizumab, but perhaps in the TMB-high setting. So can you elaborate on the patient selection there for the study?  Dr. Philippe Bedard: Yeah, that's a great question. So at the time that the study was designed in 2015, this was really the early days of immune checkpoint inhibitor therapy, so we didn't have the approvals that we have now in specific tumor types for immunotherapy and chemotherapy combinations. So when the study was designed as an investigator initiated clinical trial, the idea was really to capture patients across different tumor types - so head and neck squamous cell carcinoma, malignant melanoma, ovarian cancer, triple negative breast cancer, and a kind of mixed histology solid tumor cohort, where we knew that there were some patients who were going to be immunotherapy responsive, where there was already approvals or evidence of single agent activity, and others where the responses were more anecdotal, to try and understand in a phase 2 clinical trial with kind of a deep dive, which patients benefited from treatment and which didn't. Dr. Rafeh Naqash: Interesting approach. Going to the results, Alberto, could you help us understand some of the important findings from these data? Because there's different sections of how you tried to look at the response rates, the survival, looking at the immune deconvolution, if you could explain that. Dr. Alberto Hernando-Calvo: So the first thing that we tried was to further confirm the external validation of this immune gene expression signature, VIGex in the INSPIRE asset. So what we observed at VIGex-Hot, the category defined by VIGex-Hot tumor microenvironment, was associated with better progression free survival. After including that in a multivariable analysis adjusted by other biomarkers such as TMB, PDL-1 or tumor type, this was also confirmed for overall survival. So then the next step was to really try to hypothesize if the addition of ctDNA dynamics, taking into consideration the ctDNA quantification at baseline as compared to cycle three, if those dynamics could further improve the predictive performance of VIGex categories taken in the baseline samples. What we did observe was that, for instance, VIGex-Hot tumors in baseline tumor samples that were having a ctDNA decrease, as I mentioned before on cycle three assessment as compared to baseline, were having both better progression free survival and better prognosis overall. Another important finding was the evaluation of response rate across tumor types considering both biomarkers. I would say the most important finding is that when we were considering a cold tumor microenvironment in baseline samples before pembrolizumab initiation plus an increase in ctDNA values, what we observed is that those patients were having a 0% response rate. So this may help as a future strategy either for intensification of immunotherapy regimens in a more individualized way or for an early stop to immunotherapy and try to avoid financial toxicities as well as toxicities for our patients. Dr. Rafeh Naqash: From the data that you showed, it seems that there was a strong correlation, as you sort of mentioned, between individuals that had ctDNA clearance and baseline immune pro-inflammatory signatures. So do you really need the transcriptome signature or could the ctDNA just serve as an easy quick surrogate? Because from a cost standpoint, doing whole transcriptome sequencing or more RNA sequencing or tissue standpoint, where tissue is often limited, can become a big issue. So do you think that validation of this may perhaps more revolve around using ctDNA as an easier metric or surrogate? Or am I overestimating the utility of ctDNA? Dr. Philippe Bedard: I think it's a really good question. In our data set which was relatively small, there were 10 patients who had ctDNA clearance, meaning ctDNA that was positive at baseline was not detected. And so 9 out of those 10 patients, as you alluded to, were VIGex-Hot. So the question is a good one, could you do the same with just ctDNA clearance alone, particularly in identifying these patients who really do well, who have long term disease control on immunotherapy? I think it's a tough question to answer because the field is also changing in terms of sensitivity of detection of ctDNA tests. So we know now that there are newer generations of tests which can detect even at logs down in terms of allele variants in the circulation. So I think we need more data to address the question. I think it is important as to what is the best test, what is the endpoint that we should be using from a drug development point of view in terms of really trying to push and understand which treatment regimens are the most effective and have early readouts in terms of activity. Because we all recognize in the clinic that radiographic response doesn't tell the whole story, especially early radiographic assessments using RECIST or other criteria that we apply in clinical trials. Dr. Rafeh Naqash: From a clinical trial standpoint, we often talk about validation of these studies. You may have heard of other tests where, for example, the NCI iMatch, which is incorporating transcriptome sequencing based approach to stratify patients as an integral biomarker for treatment stratification. Is that something that you guys are thinking of using, this approach where individuals who are signature highly inflamed perhaps get lesser therapies or there's a de-intensification of some sort similar to what people are trying to do with ctDNA-based approaches? Dr. Philippe Bedard: I think that's a great question. I think it makes a lot of sense. And certainly, with the new wave antibody drug conjugates in terms of identifying patients who have expression of targets for antibody drug conjugates, that's very attractive as an approach because we don't necessarily have IHC markers for all of the different targets of antibody drug conjugates. We don't necessarily have IHC markers to completely understand different contributions to the tumor microenvironment and whether or not tumors are inflamed. But it's also a challenging approach too because RNA-seq currently is not a routine clinical test. Sometimes there are issues, particularly in patients who have stored specimens that are formalin-fixed and paraffin-embedded in terms of the quality of the RNA for RNA sequencing. And it's not always feasible to get pre-treatment biopsies and turn them around in an approach. So I think it is an attractive approach for clinical trials, but it's a hypothesis that needs to be tested. It's not something that is ready for clinical prime time today in 2024. Dr. Rafeh Naqash: One of the other interesting observations that I came across in your manuscript was that tumor mutational burden, interestingly, did not correlate with signature high tumors. What is the explanation for that? Because generally you would expect a TMB high to perhaps also have an immune gene high signature. Could it have something to do with the tumor types because there was a heterogeneous mixture of tumor type? Or I'm not sure. What else could you possibly think of that you didn't see those correlations or just sample size limitations? Dr. Alberto Hernando-Calvo: Yes. So our findings are consistent with prior data suggesting for instance T cell inflamed gene expression profile was also not correlated with tumor mutational burden and both biomarkers in a prior publication. So to have additive predictive performance for identifying patients most likely to benefit from anti PD-1 regimen, so we somehow were expecting this observation, the fact that both biomarkers are not very correlated. Dr. Rafeh Naqash: So given the proof of concept findings from your study, Phil, what is the next interesting step that you guys are thinking of to expand this? Would you think that a nivolumab-ipilimumab treated cohort would have similar findings? Or is this a treatment specific single agent immunotherapy specific correlation that you found versus something else that you may find in a nivo-ipi cohort or a doublet immune checkpoint cohort?  Dr. Philippe Bedard: The findings are really hypothesis generating. They require additional validation. And you're quite right, there may be nuances in terms of specific tumor types, combinations with other immunotherapy or combinations with chemotherapy or other agents. So I think it would be great if there are other data sets that are collecting this type of information that have ctDNA dynamics and also have transcriptome and potentially exome or genome analysis to look at these types of questions because the field is moving quickly and we really need more data sets in order to understand some of the nuances and greater numbers to validate the signals that we see. Dr. Rafeh Naqash: And one thing, as you said, the field is definitely moving very quickly. I was meeting with a company an hour back and they have an imaging-based approach using fresh tissue to look at pharmacodynamic biomarkers. And I used to work in the NCI with a group that was very interested and they developed an immuno-oncology pharmacodynamic panel that has been used and published in a few clinical trials where they did phosphorylation status. So the final theme that comes out of most of these research based studies that are being done is that one size does not fit all. But the question that comes to my mind is how many things do you necessarily need to combine to get to a predictive biomarker that is useful, that is patient centric, and that perhaps is able to identify the right therapy for the right patient. What is your take on that, Phil?  Dr. Philippe Bedard: Yeah, that's a great question too. The challenge is it depends on the context in terms of what degree of positive predictive value do you need as well as the negative predictive value to drive clinical decisions. So I think in certain situations where you don't have other approved treatment options and with a therapy that is potentially low toxicity and low financial toxicity, then I think the bar is very high in terms of being able to really confidently identify that patients aren't going to benefit. I think the nuance and the challenge becomes when you move into earlier lines of therapy, or when you talk about combinations of agents, or trying to understand within the context of other available options, particularly with treatments that have significant side effect profiles as well as financial risks, then it becomes a much more nuanced question and you really need comparative studies to understand how it fits versus the existing treatment paradigm. So I'm not really answering your question with a specific number because I think it's hard to give you a number. Some of that we also need input from patients in terms of what kind of level of validation do you need and what kind of level of discrimination do you need in order to drive decisions that are meaningful for them. Dr. Rafeh Naqash: Definitely early days, as you pointed out. More and more work in this field will hopefully lead us in the direction that we all want to go in.  Now, going to a different aspect of this podcast, which is trying to understand the trajectories for both of you, Phil and Alberto. And as you mentioned, this project seemed to have started in 2015. So I'm guessing there's a history there between Princess Margaret and Vall d'Hebron. Could you highlight that a little bit? And then perhaps, Alberto, after that you could tell us a little bit about your career when you worked at Princess Margaret as a fellow and then now back at Vall d'Hebron. Phil, you as well. Dr. Philippe Bedard: So absolutely. We have a long history of collaborating with Vall d'Hebron in Barcelona. It's really a great cancer institution with a lot of like minded individuals. We have a formal partnership and we have a lot of informal links in terms of scientists and clinicians who we work with and who we collaborate with on early phase clinical trials, as well as through different investigator networks and other translational projects. So this was really how this collaboration came about and we were fortunate to have Alberto, who came to work with us for two years and brought this great idea of looking at this signature they had developed at Vall d'Hebron in their phase one group and applying it to a data set that we had through the INSPIRE clinical trial.  Dr. Rafeh Naqash: Sounds like a very successful academia-academic collaboration, which is very nice to see. So, Alberto, could you tell us a little bit about your career trajectory and how you ended up at Princess Margaret and then back at Vall d'Hebron and what you do currently? Dr. Alberto Hernando-Calvo: Yes. So I did my oncology residency at Vall d'Hebron in Barcelona, Spain. Then I decided to further specialize in early drug development as well as head and neck cancer oncology. So I decided to pursue a clinical research fellowship under the supervision of Phil Bedard, among others. And so we decided to further validate the signature that we had developed both in the cancer genomic lab at Vall d'Hebron Institute of Oncology and the phase one unit at Vall d'Hebron, and apply the signature that have been originally tested in patients receiving anti PD-1 or anti PDL-1 combinations in early phase clinical trials. In the phase 2 clinical trial of INSPIRE, where we also had ctDNA dynamics and allowed us to test both biomarkers and see that additive predictive power when we were using both. That was one of my research topics under the mentorship of Dr. Bedard and my fellowship at Princess Margaret. And this was one of the manuscripts describing all the findings of this collaboration between Vall d'Hebron and Princess Margaret Cancer Center. Dr. Rafeh Naqash: And then, Phil, if you could highlight some of the things that you've done over the course of your career and perhaps some advice for early career junior investigators and trainees.  Dr. Philippe Bedard: I finished my oncology, medical oncology training at the University of Toronto in 2008. And then I did a breast cancer fellowship in Brussels at Breast International Group. At the time, I was really intrigued because it was really kind of the early days of microarray and RNA signatures in terms of expressing signatures were being used as part of a clinical trial that BIG was running called the MINDACT Study. And so when I finished my fellowship, I came back to Princess Margaret, started on staff. I've been here now for 15 years. I was fortunate to work with the phase 1 group and kind of my career has sort of morphed in terms of early drug development as well as genomics. I've been involved with the American Association for Cancer Research project GENIE, where I'm the current chair. This is really an international data sharing project with panel based sequencing, which both Princess Margaret and Vall d'Hebron have contributed to. And I've been fortunate to work with a number of really talented early career investigators like Alberto, who spend time with us in our drug development program and launched transitional research projects that leverage some existing data sets at their own institutions and also bring together with different research groups at our institution to lead to publications like this one. Dr. Rafeh Naqash: Thank you so much. This was very exciting. Phil and Albert, thanks for joining us today and thank you for allowing us to discuss your interesting manuscript and hopefully we'll see more of this biomarker work from you guys in the near future, perhaps published in JCO Precision Oncology.   And thank you for listening to JCO Precision Oncology Conversations. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all ASCO shows at asco.org/podcasts.     The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.  Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

Fi's off so Substitute-Jane-M is here and she comes bearing gifts for Dora! Jane and Jane chat bangers from Joseph, liberated female weeing and pleather shorts. Plus, Lady Anne Glenconner, Princess Margaret's lady-in-waiting, discusses her book 'Picnic Papers'. Our next book club pick has been announced! 'The Trouble with Goats and Sheep' by Joanna Cannon. If you want to contact the show to ask a question and get involved in the conversation then please email us: janeandfi@times.radioFollow us on Instagram! @janeandfiPodcast Producer: Eve SalusburyExecutive Producer: Rosie Cutler Hosted on Acast. See acast.com/privacy for more information.

Celebrated chef, restaurateur and TV star Rick Stein, is more than a master of seafood - he's a well-travelled storyteller with a deep-seated love for food that transcends borders. He has a new heart and a fresh outlook on life.Andy Cato, best known as one half of the pioneering electronic duo Groove Armada, is equal parts DJ, musician and forward-thinker - and now mostly a pioneering sustainable agriculture farmer. Lady Anne Glenconner is an aristocrat, author, former lady-in-waiting to Princess Margaret. She's lived a life that reads like a dramatic novel - from royal escapades and tumultuous relationships to personal tragedies; but always with glamour and grit. All that, plus we have the Inheritance Tracks of the author, broadcaster and lover of the outdoors, Kate Humble. Presenters: Nikki Bedi and Huw Stephens Producer: Ben Mitchell

Author and essayist Craig Brown is perhaps best known for his sketch comedy writing and satirical columns poking fun at the British government. But he's also a biographer, having written about subjects like Princess Margaret and The Beatles. Now, he's turned his attention to Queen Elizabeth II in a new biography, Q: A Voyage Around the Queen. In the book, Brown portrays the monarch as an anchor for the British public who penetrated the emotional psyche of a nation–even appearing in people's dreams. In today's episode, Brown joins NPR's Scott Simon to talk about what Queen Elizabeth II symbolized to people, what she would've done with her life had she not been royalty, and the unchanging nature of her character.To listen to Book of the Day sponsor-free and support NPR's book coverage, sign up for Book of the Day+ at plus.npr.org/bookofthedayLearn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

- Prime Minister Trudeau announces massive cuts to Canada's immigration targets- A deputy police chief was allegedly speeding but wasn't ticketed, Toronto Star reporter Brendan Kennedy expands on the story

- Ontario Health Minister Sylvia Jones joins the show to discuss New pre-fall economic statement announcement: expansion of fertility services - Homeowners who regularly rent on Airbnb and other sites must pay 13% tax on property value when they sell, recent tax ruling finds. Bob Aaron, real estate lawyer, breaks it down for us- What's your rule for hosting dinners when people have different dietary requests? 

In this week's episode of Gent's Talk, presented by BULOVA, host Samir Mourani sits down with paralympian hockey player Tyler McGregor to talk about being diagnosed with bone cancer as a young teenager, losing his leg and learning to cope with his new reality, learning to become a hockey player again and what phantom pain really feels like. Tyler shares insights into his career, his life and his recent work with the Princess Margaret foundation. #gentstalk Connect with us! Subscribe here ► https://www.youtube.com/@GentsTalkPodcast Website: https://gentspost.com/ Instagram: https://www.instagram.com/gentspost/ TikTok: https://www.tiktok.com/@gentstalkpod Facebook: https://www.facebook.com/gentspost/ About Gent's Talk: The Gent's Talk series, powered by Gent's Post and presented by BULOVA Canada is an episodic video podcast conversation with leading gents and rising stars across various industries. Guests include Russell Peters, James Blunt, Robin Sharma, Director X, JP Saxe, Wes Hall, Johnny Orlando, Shan Boodram, Dom Gabriel, and Nick Bateman, just to name a few. The conversations range from career, mental health, family, relationships, business, and everything in between. Gent's Talk is the first-ever video podcast to be made available for streaming on all Air Canada domestic/international flights. We aim to have a raw, unfiltered conversations about our guests' lives, how they achieved success, lessons learned along the way, and the challenges encountered. Credits: Host/Producer: Samir Mourani Creative Director and Executive Producer: Steven Branco Video & Sound Editor: Roman Lapshin A STAMINA Group Production, powered by Gent's Post.

被称为“众病之王“的癌症为何棘手？最可怕的癌症种类是哪些？我们真的有希望治愈癌症吗？在依然谈癌色变的今天，我们有幸邀请到了正在 Princess Margaret 癌症研究中心攻读博士学位的Chufan，来和我们分享她在癌症研究领域的求学之路和心路历程。从病人转变身份变为拿刀的人，从临床医学进入科研中心，在这个充满挑战与机遇的领域里，她和病人一起目睹生命的脆弱与坚强，也在实验室里努力为癌症的治愈添一块砖。从本科到硕士再到博士，从湘雅到复旦再到多伦多，Chufan一边自嘲自己抽筋式的科研，也一边建立起了独立科研者的强大内核。让我们跟随节目一起听听关于癌症研究的问题、挑战、发展方向，以及Chufan为我们送上的防癌小贴士-PhD不可能三角之好心态/好作息/无压力（不是！时间码:01:53 医学生刻板印象+1:兴趣爱好是读paper02:36癌症治疗前沿现状：我们还在谈癌色变的时代吗？06:20来自癌症研究PhD的防癌小技巧：50岁以后不要读博（不是09:10 我们真的有希望解决癌症吗？12:28抱着对肿瘤免疫的兴趣，从肺癌研究到乳腺癌研究14:52 肿瘤内科：在无力感中找到边界感，想要“征服”预后差的癌种20:00 从家庭医学百科到第一志愿第一专业录取24:00导师和导师/lab和lab的差别>>国内和国外的就读/科研差别28:17癌症研究实验究竟在做什么？31:22博士生典型：抽筋式科研34:02 当好医生不需要好奇心，但探究精神是好研究员的必需品38:20实验室里日新月异，但临床转化确实又慢又难39:59困难总会过去，掉入下一个坑就会觉得上一个也还好本期节目提到的专业：CancerResearch（癌症研究）BGM by 姚贝娜 - 也许明天

In 1953, Queen Elizabeth II and Princess Margaret attended a glamorous all-night ball. To celebrate the US and Canadian paperback release of my book "The Palace," I'm taking you into the night when Elizabeth II partied at Hampton Court.

We are still all aboard this journey with Dominick Dunne to the 60th birthday party of 3rd Lord Glenconner, Colin Tennant, with all the family. In this second part, we meet up with Princess Margaret, Raquel Welch, and a few other folks with some strong opinions when the American boat sallies up next to the Wind Star. Once the journey is over, there are a few more threads to pull with the fates and legacies of Lord Colin and Princess Margaret. It really all does come back around. Done and Dunne is taking next Monday off from the main feed, returning September 30. Patreon is the place to go to continue your investigation until then with ad-free and bonus episodes!  All sources can be found at doneanddunne.com. To advertise on Done & Dunne, please reach out to info@amplitudemediapartners.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

We are still all aboard this journey with Dominick Dunne to the 60th birthday party of 3rd Lord Glenconner, Colin Tennant, with all the family. In this second part, we meet up with Princess Margaret, Raquel Welch, and a few other folks with some strong opinions when the American boat sallies up next to the Wind Star.Once the journey is over, there are a few more threads to pull with the fates and legacies of Lord Colin and Princess Margaret. It really all does come back around.Done and Dunne is taking next Monday off from the main feed, returning September 30. Patreon is the place to go to continue your investigation until then with ad-free and bonus episodes! All sources can be found at doneanddunne.com.To advertise on Done & Dunne, please reach out to info@amplitudemediapartners.com. Learn more about your ad choices. Visit megaphone.fm/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

We are taking a voyage this week with Dominick Dunne, who is attending the 60th birthday party bash of Colin Tennant, 3rd Baron Glenconner at the end of 1986. Colin had a great party the decade before and Princess Margaret is no stranger to the party time hedonistic time happening on the island. Dunne attends this celebration, but this is not Nick's first introduction to Princess Margaret. In the first part of this getaway episode, we explore Dunne's previous relationship with Princess Margaret, fill in a bit of backstory on her land and home in Mustique, and get to the boat, right on time, for Colin's party. It truly is a family affair. All sources can be found at doneanddunne.com. Continue your investigation with ad-free and bonus episodes on Patreon! To advertise on Done & Dunne, please reach out to info@amplitudemediapartners.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

We are taking a voyage this week with Dominick Dunne, who is attending the 60th birthday party bash of Colin Tennant, 3rd Baron Glenconner at the end of 1986. Colin had a great party the decade before and Princess Margaret is no stranger to the party time hedonistic time happening on the island. Dunne attends this celebration, but this is not Nick's first introduction to Princess Margaret.In the first part of this getaway episode, we explore Dunne's previous relationship with Princess Margaret, fill in a bit of backstory on her land and home in Mustique, and get to the boat, right on time, for Colin's party. It truly is a family affair.All sources can be found at doneanddunne.com.Continue your investigation with ad-free and bonus episodes on Patreon!To advertise on Done & Dunne, please reach out to info@amplitudemediapartners.com. Learn more about your ad choices. Visit megaphone.fm/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

When Queen Elizabeth II was born in 1926, there were years of her childhood that were, compared to other future monarchs, quite normal. After all, she was never supposed to be the Queen. Her father was a second son; her Uncle David would succeed her grandfather, and certainly other male children would come along. And then, in 1930, Elizabeth's parents waited with anticipation to find out the gender of Elizabeth's impending sibling. A boy would be in the line of succession. But the child who arrived was Princess Margaret, who was never supposed to be the daughter and sister of Queens herself, but for the fateful choice her Uncle David would make when Margaret was just six, when everything changed. This episode follows Margaret through a tumultuous childhood, an early doomed romance, and her long, if ill-fated marriage to Antony Armstrong-Jones, eventually the Earl of Snowden. We visit Mustique, the Caribbean island where Margaret's only personal land holdings resided, and meet some of the guests she entertained there. Plus, an assortment of stories about the social life of a notoriously difficult Princess - and why hanging with Margaret wasn't everything it was cracked up to be. It is all going to come back around on your next Dunne Day with Nick's coverage of this Trashy Royal - this is the foundation! Learn more about your ad choices. Visit megaphone.fm/adchoices

When Queen Elizabeth II was born in 1926, there were years of her childhood that were, compared to other future monarchs, quite normal. After all, she was never supposed to be the Queen. Her father was a second son; her Uncle David would succeed her grandfather, and certainly other male children would come along.And then, in 1930, Elizabeth's parents waited with anticipation to find out the gender of Elizabeth's impending sibling. A boy would be in the line of succession. But the child who arrived was Princess Margaret, who was never supposed to be the daughter and sister of Queens herself, but for the fateful choice her Uncle David would make when Margaret was just six, when everything changed.This episode follows Margaret through a tumultuous childhood, an early doomed romance, and her long, if ill-fated marriage to Antony Armstrong-Jones, eventually the Earl of Snowden. We visit Mustique, the Caribbean island where Margaret's only personal land holdings resided, and meet some of the guests she entertained there. Plus, an assortment of stories about the social life of a notoriously difficult Princess - and why hanging with Margaret wasn't everything it was cracked up to be.It is all going to come back around on your next Dunne Day with Nick's coverage of this Trashy Royal - this is the foundation! Learn more about your ad choices. Visit megaphone.fm/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

When Queen Elizabeth II was born in 1926, there were years of her childhood that were, compared to other future monarchs, quite normal. After all, she was never supposed to be the Queen. Her father was a second son; her Uncle David would succeed her grandfather, and certainly other male children would come along.And then, in 1930, Elizabeth's parents waited with anticipation to find out the gender of Elizabeth's impending sibling. A boy would be in the line of succession. But the child who arrived was Princess Margaret, who was never supposed to be the daughter and sister of Queens herself, but for the fateful choice her Uncle David would make when Margaret was just six, when everything changed.This episode follows Margaret through a tumultuous childhood, an early doomed romance, and her long, if ill-fated marriage to Antony Armstrong-Jones, eventually the Earl of Snowden. We visit Mustique, the Caribbean island where Margaret's only personal land holdings resided, and meet some of the guests she entertained there. Plus, an assortment of stories about the social life of a notoriously difficult Princess - and why hanging with Margaret wasn't everything it was cracked up to be.Listen ad-free at patreon.com/trashyroyalspodcast.To advertise on this podcast, reach out to info@amplitudemediapartners.com. Learn more about your ad choices. Visit megaphone.fm/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

When Queen Elizabeth II was born in 1926, there were years of her childhood that were, compared to other future monarchs, quite normal. After all, she was never supposed to be the Queen. Her father was a second son; her Uncle David would succeed her grandfather, and certainly other male children would come along. And then, in 1930, Elizabeth's parents waited with anticipation to find out the gender of Elizabeth's impending sibling. A boy would be in the line of succession. But the child who arrived was Princess Margaret, who was never supposed to be the daughter and sister of Queens herself, but for the fateful choice her Uncle David would make when Margaret was just six, when everything changed. This episode follows Margaret through a tumultuous childhood, an early doomed romance, and her long, if ill-fated marriage to Antony Armstrong-Jones, eventually the Earl of Snowden. We visit Mustique, the Caribbean island where Margaret's only personal land holdings resided, and meet some of the guests she entertained there. Plus, an assortment of stories about the social life of a notoriously difficult Princess - and why hanging with Margaret wasn't everything it was cracked up to be. Listen ad-free at patreon.com/trashyroyalspodcast. To advertise on this podcast, reach out to info@amplitudemediapartners.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

Special guest Sarah Sahim joins us to discuss Richard E. Grant's autobiographical film Wah Wah, about the dissolution of his parents marriage and his father's alcoholism, agains the backdrop of the end of British colonial rule in Swaziland. What does this have to do with King Arthur? Well, as a goodbye gift to the visiting Princess Margaret, the British colonial community puts on a production of Camelot with a black Lancelot. A frustrating and frequently incurious film all around that squanders any opportunity to really grapple with the meaning of the end of an empire. Starring Gabriel Byrne, Nicholas Hoult, Emily Watson, and Miranda Richardson. Written and directed by Richard E. Grant.   To hear the entire episode, join the Mary Versus the Movies patreon for $3/month to hear this and the entire series Hollywood Avalon: https://www.patreon.com/maryvsmovies.  

Glamis Castle is situated beside the village of Glamis in Angus, Scotland. It is the home of the Earl of Strathmore and Kinghorne, and is open to the public.Glamis Castle has been the home of the Lyon family since the 14th century, though the present building dates largely from the 17th century. Glamis Castle was the childhood home of the late Queen Elizabeth, The Queen Mother. Her second daughter, Princess Margaret was born there on 21 August 1930.The castle is protected as a category A listed building, and the grounds are included on the Inventory of Gardens and Designed Landscapes in Scotland, the national listing of significant gardens.It also has more ghouls & mysteries patrolling it's castle walls than a Castlevania game.Support the pod:www.patreon.com/monsterfuzzCheck out our merch:https://monster-fuzz.creator-spring.comEverything else!www.linktr.ee/monsterfuzz

La princesse Margaret n'a jamais été une altesse sans couronne. Elle fut au contraire la reine de pique de l'Angleterre, le double extravagant et désespéré de sa sœur Elizabeth. Un miroir brisé qui brillait de tous ses éclats mais dans lequel la royauté n'osait pas se regarder de peur de s'y reconnaître. L'invité Confidentiel : Jérôme Carron, grand reporter au magazine Point de Vue.

Nick is joined by Racing Post senior writer Lee Mottershead to discuss the latest developments in the Horseracing world. Today they begin by looking ahead to an evening of contrasts, with 1,000 Guineas favourite Bedtime Story appearing at Leopardstown coinciding with the start of the Racing League, one of whose Team Captains Kevin Blake joins the show. Also today, trainer Ollie Sangster anticipates big things from Simmering in Saturday's Princess Margaret, Ed Walker looks ahead to English Oak in next week's Lennox Stakes at Glorious Goodwood, ex-jockey George Chaloner tells us about his exciting new venture running Cliff Stud in Yorkshire, while BEBF Chair Simon Sweeting highlights the raft of upcoming high value maiden races. Nick and Lee also have a go at predicting the identity of the new BHA Chair

On this episode I speak with Set Decorator Alison Harvey about the epic Netflix series “The Crown” Having been on the project for over 8 years this final season holds a special place in telling the life of Queen Elizabeth. This final season included sets that depicted the death of Diana, Princess of Wales, the Golden Jubilee of Elizabeth II, the deaths of Princess Margaret and Queen Elizabeth The Queen Mother, and the wedding of Prince Charles and Camilla Parker Bowles and more. We talk about the color pallant of the decor changing over the seasons, some of the hardest sets to decorate and giving this amazing series a glorious set to end on.

The human dynamo that is Anne de Courcy returns to the podcast by popular demand after her brilliant interview about Princess Margaret and Tony Snowdon. This week she is speaking about one of her most successful books ‘The Viceroy's Daughters', the saga of Lord Curzon and his three talented, beautiful but often wayward daughters at the pinnacle of British and imperial high society in the first half of the 20th Century.Overlapping love affairs, dalliances with dangerous young men and campaigning alongside the most charismatic politician of the age, Oswald Mosley, the former socialist turned fascist leader of Britain's ‘Black Shirts' in the 1930s - this is a story with everything and an incredible window into a glittering but also menacing world of privilege, power and decadence. If you want to support what we do and help us grow this podcast, please hit the ‘Like' button and we now also have a Thank You option on YouTube for donations starting at 2 UK pounds - find it by clicking on the 'three dots' next to the ‘download' button. You can buy Anne's books and those of the other authors we feature in our own bookshop, along with thousands of others. All profit are shared between podcasters and independent booksellers...https://uk.bookshop.org/p/books/the-viceroy-s-daughters-anne-de-courcy/5024095?aid=12054&ean=9780753812556& Looking for the perfect gift for a special scandalous someone - or someone you'd like to get scandalous with? We're here to help...https://www.etsy.com/uk/shop/ScandalMongers *** If you enjoy our work please consider clicking the YouTube subscribe button, even if you listen to us on an audio app. It will help our brand to grow and our content to reach new ears.THE SCANDAL MONGERS PODCAST is also available to watch on YouTube...https://www.youtube.com/@thescandalmongerspodcast/videosAndrew Lownie...https://twitter.com/andrewlowniePhil Craig...https://twitter.com/philmcraigThe Scandal Mongers...https://twitter.com/MongersPodcastYou can get in touch with the show hosts via...team@podcastworld.org(place 'Scandal Mongers' in the heading please).Production byTheo XKerem IsikProduced byPodcastWorld.org Hosted on Acast. See acast.com/privacy for more information.

Queen Elizabeth and Princess Margaret take a trip down memory lane to a fateful evening at The Ritz. In the present day Margaret's health is declining, but that won't stop her from living her life her way.   To support the LoG on Patreon visit: https://www.patreon.com/lordsofgrantham To buy LoG Merchandise visit: https://www.teepublic.com/user/lords-of-grantham-podcast

The Cannes Film Festival is in full swing in the South of France, and one of the big stories everyone is following concerns Francis Ford Coppola. Forty-five years after he won the Palme d'Or for Apocalypse Now, he is back with his latest film, Megalopolis. He has spent more than $100 million of his own money on the film and is at the festival looking for a distributor. Our own Sam Wasson will tell us how one of the titans of moviemaking found himself hat in hand. Then Stuart Heritage will join us from the U.K., where he will tell us about what is known to be the worst hotel in Great Britain. And James Eli Shiffer has the incredible story of an American woman from Minnesota who discovered that she is the secret daughter of an Italian banker and senator who cavorted with Jackie Kennedy and Princess Margaret and was the face of the 1970s jet set.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Susannah Constantine first burst onto our TV screens in the late 90s, alongside her partner-in-style, Trinny Woodall. Together, they revolutionised the way women approach fashion with their ground-breaking show 'What Not to Wear', as the iconic duo Trinny & Susannah. The series not only garnered international acclaim but also became a cultural phenomenon, empowering women to embrace their bodies and dress with confidence, taking them all over the world from The Oprah Winfrey Show to the Oscars red carpet. This, we discuss, was just one chapter in Susannah's fascinating life. In her 20s she was in a long-term relationship with Viscount David Linley, the son of Princess Margaret, and we chat today about her travels with Princess Margaret and how she viewed her very much as a mother figure in her life. Susannah is also a bestselling author, and a very successful podcaster - her podcast, My Wardrobe Malfunction, has had 9 seasons, and the most incredible guest lineup from Elizabeth Hurley to Nile Rodgers.Travel quite clearly means a lot to Susannah and she evokes the destinations in her travel diaries today, from Cornwall to Canada, Pakistan to Antarctica, so vividly, and emotively.Destination Recap:Holly - Four Seasons Ritz Lisbon, PortugalSusannah - AntarcticaGassin, France St Tropez, France Olhão, Portugal MustiqueVancouver Island, British Columbia, CanadaClinton, British Columbia, CanadaPakistanHelford Passage, Cornwall Cairngorms, Scotland Soverato, Calabria, Italy Nairobi, KenyaAntarctica Susannah was on a Viking cruise to Antarctica, and Viking provides destination-focused journeys on rivers, oceans and lakes across all seven continents and destination-focused expeditions in Antarctica, the Arctic and North America's Great Lakes. And you can find Susannah' podcast my wardrobe malfunction wherever you get your podcasts. Thanks so much for listening today. If you'd like to hear more from the podcast don't forget to hit subscribe, or if you use Apple Podcasts to press follow so that a new episode lands in your podcast app each week. If you want to be the first find out who is joining me on next week's episode come and follow me on Instagram I'm @hollyrubenstein, and you'll also find me on Threads and TikTok - I'd love to hear from you.And if you can't want until then remember there's the first ten seasons to catch up on, that's over 110 episodes to keep you busy there. Don't forget that all the destinations mentioned by my guests are included in the episode show notes here on your podcast app, and listed on my website, thetraveldiariespodcast.com Hosted on Acast. See acast.com/privacy for more information.

Plus, Elizabeth Hurley is talking about her son filming her in sex scenes?!  Learn more about your ad choices. Visit megaphone.fm/adchoices

This week, we take The Kid through conquering the 1970s. From hit films like Love Story, The Godfather and The Great Gatsby to two marriages and divorces from Ali MacGraw and Phyllis George, this decade was filled for Robert Evans with all the ups and downs. Appearances in the episode include, but are in no way limited to, Ryan O'Neal, Robert Redford, Al Pacino and even Princess Margaret.All sources can be found at doneanddunne.com.Continue your investigation with ad-free and bonus episodes on Patreon!To advertise on Done & Dunne, please reach out to sales@advertisecast.com or visit https://www.advertisecast.com/DoneDunne. Learn more about your ad choices. Visit megaphone.fm/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week, we take The Kid through conquering the 1970s. From hit films like Love Story, The Godfather and The Great Gatsby to two marriages and divorces from Ali MacGraw and Phyllis George, this decade was filled for Robert Evans with all the ups and downs. Appearances in the episode include, but are in no way limited to, Ryan O'Neal, Robert Redford, Al Pacino and even Princess Margaret. All sources can be found at doneanddunne.com. Continue your investigation with ad-free and bonus episodes on Patreon! To advertise on Done & Dunne, please reach out to sales@advertisecast.com or visit https://www.advertisecast.com/DoneDunne. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Spoiler Alert: This bonus episode is all about the last six episodes of The Crown season 6! Ladies Rachel and Roberta are joined by the delightful Sam Sanders, host of Stitcher's Vibe Check podcast, to discuss The Crown's grand finale, from the Princess Margaret bathtub scene to whether Kate ever met Diana in real life. Also, listen in to find out who is crowned the best actor of part 2, what Peter Morgan got right and wrong, and our thoughts on Carole Middleton. That and so much more, so grab a drink and get ready to laugh along with us.--Presented by PureWow and Gallery Media Group. Follow all the royal news at purewow.com/royals. Follow us on Instagram at @RoyallyObsessedPodcast.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In the aftermath of Princess Margaret's death, the Queen approaches her Golden Jubilee with more trepidation than ever before. With her mother's health in decline, she finds herself vulnerable to the attacks of Mohamed Al Fayed who pursues a high-profile campaign to prove responsibility for Diana's death lies with the Royal Family. Meanwhile, between his blossoming romance with Kate and the re-opened case surrounding his mother's death, William seeks to lead as normal a life as possible while he still can.   Edith Bowman speaks with director Erik Richter-Strand about showing a more vulnerable side of the Queen, and Head of Research Annie Sulzberger introduces researcher Anna Basista to give insight into the Paget Report. Actor Marcia Warren reflects on playing the Queen Mother and Edith meets The Crown's Prince Harry, Luthor Ford – in his first ever interview.   The Crown: The Official Podcast is produced by Netflix and Sony Music Entertainment, in association with Left Bank Pictures.    Host: Edith Bowman  Guests: Erik Richter-Strand, Marcia Warren, Annie Sulzberger, Anna Basista, Luther Ford.

Whilst holidaying in Mustique, Princess Margaret suffers a stroke and is suddenly forced to reassess her lifestyle. Margaret is keen to recover in anticipation of her seventieth birthday, but the Queen remains concerned that her party-loving sister will not be able to kick the habits of a lifetime in order to heal. As Margaret's health continues to decline, she finds herself slipping back into her memories, back to her secret night out with her sister during the biggest party in history: VE Day 1945. The memories from that evening, and what it taught her about her older sister, comfort her in her final days.   Edith Bowman speaks with co-writer Meriel Sheibani-Clare and director Alex Gabassi about exploring Princess Margaret's final years. Producer Martin Harrison talks recreating 1945 and actor Lesley Manville says goodbye to Princess Margaret.   The Crown: The Official Podcast is produced by Netflix and Sony Music Entertainment, in association with Left Bank Pictures.  Host: Edith Bowman  Guests: Meriel Sheibani-Clare, Alex Gabassi, Martin Harrison, Lesley Manville.

Richard, Chris, and Hillary discuss The Crown's farewell to Princess Margaret in season 6, episode 8, "The Ritz"—and later, the celebrated actor details how she prepared for her showcase episode, as well as her long friendship with fellow Crown star Imelda Staunton. 

Princess Margaret, Queen Elizabeth II's younger sister, was one of the most famous and glamorous women of the 20th century. But her life was lived in view of, and in response to, the tabloid scandals that threatened to undo her. Support Noble Blood: — Bonus episodes, stickers, and scripts on Patreon — Merch! — Order Dana's book, 'Anatomy: A Love Story' and its sequel 'Immortality: A Love Story'See omnystudio.com/listener for privacy information.