Podcasts about Tomography

In this episode of SpaceTime, we dive into groundbreaking research revealing the true composition of the Earth's core, explore new insights into solar neutrinos, and uncover the complexities of Martian volcanoes.Earth's Core Contains Vast Hydrogen ReservoirA recent study published in Nature Communications indicates that Earth's core may hold up to 45 oceans' worth of hydrogen, challenging the long-held belief that water on our planet primarily came from asteroids and comets. Utilizing advanced laboratory techniques, researchers simulated the extreme conditions of the core to uncover its surprising hydrogen content, suggesting a significant internal source of water far beyond previous estimates.Neutrinos from the Sun's CoreA new dark matter experiment has successfully detected neutrinos originating from the Sun's core, marking a significant milestone in our understanding of these elusive particles. The LZ experiment at the Sanford Underground Research Facility captured signals from Brian 8 solar neutrinos, providing valuable data on solar processes and setting new limits for dark matter research. This breakthrough highlights the potential of neutrino studies in unraveling the mysteries of both dark matter and stellar dynamics.Complexity of Martian VolcanoesNew findings published in Geology reveal that young Martian volcanoes are far more complex than previously thought. Researchers have discovered that these volcanoes were shaped by long-lasting and evolving magma systems rather than single eruptions. By analyzing surface features and mineral compositions from orbit, scientists have reconstructed the intricate eruptive history of these volcanic systems, shedding light on the Red Planet's geological past.www.spacetimewithstuartgary.com✍️ Episode ReferencesNature Communications, GeologyBecome a supporter of this podcast: https://www.spreaker.com/podcast/spacetime-with-stuart-gary--2458531/support.(00:00:00) New study reveals Earth's core may contain vast amounts of hydrogen(00:08:30) Breakthrough in solar neutrino detection from the Sun's core(00:16:45) Insights into the complex eruptive history of Martian volcanoes(00:25:00) Science report: The link between caffeine consumption and reduced dementia risk(00:32:15) Study on the frequency of passionate love experiences in humans

In this episode of the Heart podcast, Digital Media Editor, Professor James Rudd, is joined by Prof. Filippo Cademartiri from Naples, Italy. They discuss all aspects of this emerging CT technology that promises lower radiation imaging, with higher resolution and excellent in-stent imaging, but at a significant cost in terms of hardware. If you enjoy the show, please leave us a positive review wherever you get your podcasts. It helps us to reach more people - thanks! Link to published paper: https://heart.bmj.com/content/early/2025/05/14/heartjnl-2025-325790

Listen to opticians discuss the newest eye care and eye health technologies, which are fighting rising eye health issues like myopia and helping patients of all ages, including children, see well. Learn more at https://www.theeyecube.com/ The Eye Cube City: London Address: 256 West End Lane, West Hampstead, NW6 1LJ Website: https://www.theeyecube.com/

This week's special guest, Andi Hektor, takes us on a deep dive into his journey from academia to entrepreneurship, how GScan is tackling critical infrastructure challenges, and why he chose Cambridge as the company's UK base.GScan is pioneering Muon tomography, an advanced scanning technology originally used for border security but now revolutionising non-destructive testing (NDT) in construction. The technology helps detect corrosion and structural weaknesses in bridges and buildings, preventing costly and environmentally harmful demolitions. “Bridges are often demolished as a precaution because engineers can't see inside them. We provide that visibility, potentially doubling their lifespan.”Initially setting up in London, Andi quickly realised Cambridge's startup ecosystem was the ideal home for GScan: “London's tech scene is great, but for deep tech, it's easy to get lost. In Cambridge, you can build a network fast. The Bradfield Centre has been amazing.” Hosted on Acast. See acast.com/privacy for more information.

Adrian Mendes, CEO of Perimeter Medical Imaging AI, is solving the problem of margin assessment in cancer surgery. Surgeons often have to perform a second surgery on breast cancer patients because they are unable to completely remove all of the cancerous cells the first time. The company has developed Optical Coherence Tomography (OCT) imaging technology that allows surgeons to see cells at a microscopic level in real-time during surgery, helping them remove the tumor and all surrounding cancerous tissue. Adrian explains, "The surgeon is trying to ensure that when they extract the tumor and the cancer, there is a margin of healthy cells around it. Studies have shown that if they can achieve that, and with breast cancer, that margin needs to be two millimeters generally, then the likelihood of them having left cancer cells back in the body goes down drastically. This is every surgeon's objective for cancer treatment. We help the surgeons ensure that they've achieved what they call clean margins." "Yes, it's quite significant. So, for breast cancer surgery alone, it's about one in every five surgeries are unsuccessful because the margins aren't clean, and then the patient has to come back for a second surgery. So, there are about 300,000 breast cancer surgeries per year in the United States. If you think about 20% of that, there are a lot of women that are having to go back for a second surgery every year. That's just in the United States. And it's a global problem." "What's unique about our technology is we use an imaging tech called OCT or Optical Coherence Tomography that allows images to be created down at around 15-micron width level. And that's small enough to be able to distinguish cells. And so with that, it just gives the surgeon so much more ability to see what they're looking at." "The next generation uses the same imaging modality, the OCT imaging, but it adds an artificial intelligence and AI layer to it. So what we've done is trained an AI algorithm to recognize suspicious areas inside images of breast tissue. And these suspicious areas are indicative of cancer. The way we train the model is we have a library of about 2 million images of breast tissue, both cancerous and healthy tissue, and we've got labels that have been provided by pathologists." #PerimeterMedical #Oncology #BreastCancerSurgery #OCT #Tumors #MedAI perimetermed.com Listen to the podcast here

Adrian Mendes, CEO of Perimeter Medical Imaging AI, is solving the problem of margin assessment in cancer surgery. Surgeons often have to perform a second surgery on breast cancer patients because they are unable to completely remove all of the cancerous cells the first time. The company has developed Optical Coherence Tomography (OCT) imaging technology that allows surgeons to see cells at a microscopic level in real-time during surgery, helping them remove the tumor and all surrounding cancerous tissue. Adrian explains, "The surgeon is trying to ensure that when they extract the tumor and the cancer, there is a margin of healthy cells around it. Studies have shown that if they can achieve that, and with breast cancer, that margin needs to be two millimeters generally, then the likelihood of them having left cancer cells back in the body goes down drastically. This is every surgeon's objective for cancer treatment. We help the surgeons ensure that they've achieved what they call clean margins." "Yes, it's quite significant. So, for breast cancer surgery alone, it's about one in every five surgeries are unsuccessful because the margins aren't clean, and then the patient has to come back for a second surgery. So, there are about 300,000 breast cancer surgeries per year in the United States. If you think about 20% of that, there are a lot of women that are having to go back for a second surgery every year. That's just in the United States. And it's a global problem." "What's unique about our technology is we use an imaging tech called OCT or Optical Coherence Tomography that allows images to be created down at around 15-micron width level. And that's small enough to be able to distinguish cells. And so with that, it just gives the surgeon so much more ability to see what they're looking at." "The next generation uses the same imaging modality, the OCT imaging, but it adds an artificial intelligence and AI layer to it. So what we've done is trained an AI algorithm to recognize suspicious areas inside images of breast tissue. And these suspicious areas are indicative of cancer. The way we train the model is we have a library of about 2 million images of breast tissue, both cancerous and healthy tissue, and we've got labels that have been provided by pathologists." #PerimeterMedical #Oncology #BreastCancerSurgery #OCT #Tumors #MedAI perimetermed.com Download the transcript here

Interview with Benjamin K. Young, MD, MS, author of Ultra-Widefield Optical Coherence Tomography Beyond the Ora Serrata in Retinopathy of Prematurity. Hosted by Neil M. Bressler, MD. Related Content: Ultra-Widefield Optical Coherence Tomography Beyond the Ora Serrata in Retinopathy of Prematurity

Interview with Benjamin K. Young, MD, MS, author of Ultra-Widefield Optical Coherence Tomography Beyond the Ora Serrata in Retinopathy of Prematurity. Hosted by Neil M. Bressler, MD. Related Content: Ultra-Widefield Optical Coherence Tomography Beyond the Ora Serrata in Retinopathy of Prematurity

OCCUPI – Optical Coherence Tomography-Guided Coronary Intervention in Patients with Complex Lesions

Entrevista a Miguel Vidal, cofundador de North Tomography

Entrevista a Miguel Vidal, cofundador de North Tomography

Commentary by Dr. Candice Silversides

Ettore Biondi, California Institute of Technology Traveltime-based tomographic methods have been extensively explored and employed by researchers since the 80s. Such algorithms have been successfully applied to various geophysical applications, ranging from seismic exploration to global to regional seismological scales. However, given the advancements in computational architectures over the last 20 years, full-waveform methodologies are now dominating most of the subsurface-parameter inversion applications. These workflows seek to match all the waveforms present within active seismic data or synthetic Green’s functions obtained by cross-correlating ambient noise. Despite this decrease in the popularity of traveltime-based tomographic approaches, these methods have great potential to be successful when applied to distributed acoustic sensing (DAS) data for seismic applications. DAS instruments can operate on existing telecommunication fibers and transform them into large-scale high-resolution seismic arrays. We demonstrate such potential by applying an Eikonal traveltime double-difference tomography algorithm to DAS data recorded in the Long Valley caldera, located in the Eastern Sierra region of California. This active volcanic area has been extensively studied in the last 50 years and its recent unrest remains still poorly understood. We employ two DAS arrays composed of almost 9000 channels along a 90-km north-south transect across the caldera to characterize the subsurface structures present underneath the area. We use almost 2000 cataloged events and apply a machine-learning algorithm to accurately pick their P and S arrival times necessary for the tomography. The range and spatial resolution of the DAS arrays allow us to retrieve structures that could not be resolved by previous studies that employed only conventional station recordings. Our results agree well with previous studies and highlight the presence of a low-velocity basin along the Mono-Inyo craters. Both P- and S-wave models also show a low-velocity structure centered below Mono Lake, which agrees with historical gravity surveys. Moreover, the low Vp/Vs ratio inverted below the Long Valley caldera suggests a lack of newly intruded materials at depth above 10 km and a clear separation between the shallow low-velocity basins and the ≥10-km deep magmatic reservoir.

BestPodcastintheMetaverse.com Canary Cry News Talk #742 05.20.2024 - Recorded Live to 1s and 0s GREENE FIREBALLS | Congress Chaos, Iran President, Nephilim Bird Flu Deconstructing Corporate Mainstream Media News from a Biblical Worldview Declaring Jesus as Lord amidst the Fifth Generation War! TJT Youtube (backup) Channel: https://www.youtube.com/@TheJoyspiracyTheory The Show Operates on the Value 4 Value Model: http://CanaryCry.Support Join the Supply Drop: https://CanaryCrySupplyDrop.com                   Submit Articles: https://CanaryCry.Report Submit Art: https://CanaryCry.Art Join the T-Shirt Council: https://CanaryCryTShirtCouncil.com Podcasting 2.0: https://PodcastIndex.org Resource: Index of MSM Ownership (Harvard.edu)             Resource: Aliens Demons Doc (feat. Dr. Heiser, Unseen Realm) Resource: False Christ: Will the Antichrist Claim to be the Jewish Messiah Tree of Links: https://CanaryCry.Party   Join the Canary Cry Roundtable   This Episode was Produced By: Executive Producers Sir LX Protocol V2 Knight of the Berrean Protocol*** Sir Jamey Not the Lanister***   Producers of Treasure Roderick B, Sir Marti K Knight of the Wrong Timeline, Elle O, Sir Scott Knight of Truth, DrWhoDunDat, Misses TinFoilHatMan, Dame Gail, Veronica D, Sir Casey the Shield Knight   CanaryCry.ART Submissions JonathanF, Little Owen, Sir Marti K   CONTENT PRODUCTION (Microfiction etc.) Stephen S - Lone Scum, CEO of BuyMyTek commented on the viral video of Bawsten Dynamics' humanoid robot, “That's pretty disturbing; that will scare children and pets.  We need to be more pet friendly.  Add  puppy dog eyes and purring.”   JOLMS - Reading no response from the pilot, the P.A.D.  determined that the reports from the flight deck's onboard instruments were founded and thereby accepted the emergency level 1 clearance. It turns to read the HUD.On the left window are planetary statistics. Weather, Power, Tomography and Topology scans Etc  Etc. (Out of date). The window below held more personal features. An [ envelope ] icon. A [calendar] icon, (bla bla bla) Then curiously… a [ Wireless signal ] icon. Crossed out. ‘Huh' PAD wondered.      TIMESTAMPERS Jade Bouncerson, Morgan E   CanaryCry.Report Submissions JAM   REMINDERS Clankoniphius   SHOW NOTES/TIMESTAMPS Podcast T- 07:45 PreShow Prayer from Basil: 07:46 V / 00:01 P HELLO, RUN DOWN 11:51 V / 04:06 P RACE WARS/POLYTICK 13:51 V / 06:06 P Clip: MTG vs AOC vs Crocket Clip: The crucial moment from Rep. Crockett, MTG's heated exchange (MSNBC)   SPACE/BIBLICAL 39:50 V / 32:05 P Bright green fireball lights up the skies over Portugal and Spain (Space.com) Clip: Meteor over Portugal   DAY JINGLE/V4V/EPs/TREASURE 48:49 V / 41:04 P   FLIPPY/BEING WATCHED 01:13:36 V / 01:05:51 P Flippy in Space! Helping astronauts recover form embarrassing falls. (Robot Report)   WW3 01:23:52 V / 01:16:07 P Clip: Iran's President Raisi killed in helicopter crash (CNN) → Naftali X posts 1, 2, Clip 3 Slav Prime Minister Gunned Down in Politically Motivated attack (CNN)   TALENT/TIME/TREASURE 02:01:42 V / 01:53:57 P   ANTARCTICA/BIRD FLU 02:18:26 V / 02:10:41 P Bird Flu haws BREACHED remote Antarctica (ABC) US post influenza A wastewater data online to assist bird flu probe, official (Reuters)  2 possible bird flu vaccines could be available within weeks, if needed (NBC News)  Bird Flu Engineered to Infect Humans Could Be Lab-Produced ‘in Months,' (PJ Media)    OUTRO 02:37:27 V / 02:29:42 P END

Fractional Flow Reserve or Optical Coherence Tomography to Guide the Management of Patients with Angiographically Intermediate Coronary Stenosis

Dr. David Huang joins the show to share his story of developing optical coherence tomography (OCT), for which he, Dr. James Fujimoto, and Eric Swanson won the National Medal of Technology, the highest award for innovators in the United States, as well as the 2023 Lasker–DeBakey Clinical Medical Research Award, often called "America's Nobel Prize." For all episodes or to claim CME credit for selected episodes, visit www.aao.org/podcasts.

Commentary by Dr. Valentin Fuster

Matthew Silva, PhD, CEO of EMIT Imaging, answers questions from a recent webinar where he highlights the role of cryo-fluorescence tomography in advancing the field of immunotherapy research.

Ever wondered how atom probe tomography advances our understanding of semiconductors and improves device performance?In today's episode, we dive deep into the world of semiconductors as we explore the fascinating realm of atom probe tomography. Our guest expert, David Larson, sheds light on the intricacies of this powerful materials characterization technique. From minimizing damage and improving yield to overcoming challenges in data reconstruction, David shares insights on the latest advancements and future possibilities in the field. Tune in to gain a deeper understanding of semiconductors and atom probe technology's role in their analysis.Join us as we discuss the following:The use of a Focused Ion Beam (FIB) at liquid nitrogen temperature to minimize damage and improve yieldChallenges of yield and spatial distortion in atom probe technologyHow different laser wavelengths can enhance reconstruction and yield in heterogeneous structuresHow modeling and in situ measurements play a crucial role in predicting the field of operationThe limitations, growth, and future improvements of atom probe technology, including its application in analyzing real devicesContact Markus Kuhn on LinkedIn for any potential guest requests or episode ideas.To ensure you never miss an episode of the Understanding Semiconductor podcast, subscribe to Apple Podcasts, Spotify, Google, or our website. Listening on a desktop & can't see the links? Just search for Understanding Semiconductors in your favorite podcast player.

Optical coherence tomography (OCT) is a powerful imaging tool used across multiple clinical disciplines. JAMA Executive Editor Gregory Curfman, MD, speaks with 2023 Lasker Award recipient James G. Fujimoto, PhD, professor of electrical engineering at MIT, about his role in developing OCT and OCT's advancements in clinical practice. Related Content: Optical Coherence Tomography—History, Evolution, and Future Prospects

Commentary by Dr. Valentin Fuster

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.03.551868v1?rss=1 Authors: Lin, Z., Zhang, X., Nandi, P., Lin, Y., Wang, L., Chu, Y., Paape, T., Yang, Y., Xiao, X., Liu, Q. Abstract: X-ray tomography and x-ray fluorescence imaging are two non-invasive imaging techniques to study cellular structures and chemical element distributions, respectively. However, correlative X-ray tomography and fluorescence imaging for the same cell has yet to be routinely realized due to challenges in sample preparation and X-ray radiation damage. Here we report an integrated experimental and computational workflow for achieving correlative multi-modality X-ray imaging of a single cell. The method consists of the preparation of radiation-resistant single-cell samples using live-cell imaging-assisted chemical fixation and freeze-drying procedures, targeting and labeling cells for correlative x-ray tomography and x-ray fluorescence measurement, and computational reconstruction of the correlative and multi-modality images. With X-ray tomography, cellular structures including the overall structure and intracellular organelles are visualized, while X-ray fluorescence imaging reveals the distribution of multiple chemical elements within the same cell. Our correlative method demonstrates the feasibility and broad applicability of using X-rays to understand cellular structures and the roles of multiple chemical elements and related proteins in signaling and other biological processes. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.16.549168v1?rss=1 Authors: Schrad, J. R., Fu, G., Hable, W. E., Tayar, A. M., Oliveira, K., Nicastro, D. Abstract: Cilia and flagella play a crucial role in the development and function of most eukaryotic organisms. The structural core of the flagellum, the axoneme, is conserved in most eukaryotes and careful regulation of dynein motors within the axoneme is required for proper ciliary beating. The sperm flagellum from the American eel (Anguilla rostrata) has been shown to lack many of the canonical axonemal proteins, including the radial spokes, the central pair complex, and possibly even the outer row of dynein arms, presenting a "minimal" flagellar system. Here, we present cryo-electron tomography analysis of the eel sperm flagellum. We identified two states for the eel sperm flagellum within our tomograms, narrow and wide, and found that the flagellum started narrow near the sperm head and widened distally. Subtomogram averages revealed that the eel sperm flagellum has retained remnants of the missing regulatory complexes, including a short radial spoke 3 complex, basal components of radial spokes 1 and 2, and an outer dynein arm docking complex. We also describe unique structural features of the A. rostrata sperm flagellum, such as a unique pattern of holes at the inner junction and an accessory complex located at the "outer" junction. Finally, we discuss the consequences of losing key regulatory factors for the eel sperm flagellum and hypothesize several evolutionary factors that may have led to their loss. Together, our results shed light onto the structure and function of the eel sperm axoneme and provide insight into the minimum requirements for proper ciliary beating. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.12.547497v1?rss=1 Authors: Kislinger, G., Fabig, G., Wehn, A. C., Rodriguez, L., Jiang, H., Niemann, C., Klymchenko, A. S., Plesnila, N., Misgeld, T., Mueller-Reichert, T., Khalin, I., Schifferer, M. Abstract: Like other volume electron microscopy approaches, Automated Tape Collecting Ultramicrotomy (ATUM) enables imaging of serial sections deposited on thick plastic tapes by scanning electron microscopy (SEM). However, ATUM is unique by enabling hierarchical imaging and thus efficient screening for target structures as needed e.g., for correlated light and electron microscopy. However, SEM of sections on tape can only access the section surface, thereby limiting the axial resolution to the typical size of cellular vesicles, an order of magnitude lower than the acquired xy resolution. In contrast, serial-section electron tomography (ET), a transmission electron microscopy-based approach, yields isotropic voxels at full EM resolution, but requires deposition of sections on electron-permeant thin and fragile monolayer films - thus making screening of large section libraries difficult and prone to section loss. To combine the strength of both approaches, we developed ATUM-Tomo, a hybrid method, where sections are first reversibly attached to plastic tape via a dissolvable coating, and after screening detached and transferred to the ET-compatible thin films. Thus, ATUM-SEM of serial semi-thick sections and consecutive ET of one selected section combines SEM's fast target recognition and coarse rendering capability with ET's high-resolution volume visualizations - thus enabling multi-scale interrogation of cellular ultrastructure. As a proof-of-principle, we applied correlative ATUM-Tomo to study ultrastructural features of blood brain barrier (BBB) leakiness around microthrombi in a mouse model of traumatic brain injury. Microthrombi and associated sites of BBB leakiness were identified by confocal imaging of injected fluorescent and electron-dense nanoparticles, then relocalized by ATUM-SEM, and finally interrogated by correlated ATUM-Tomo, a workflow which created a seamless zoom-in on structural BBB pathology from the micro- to the nanometer scale. Overall, our new ATUM-Tomo approach will substantially advance ultrastructural analysis of biological phenomena that require cell- and tissue-level contextualization of the finest subcellular textures. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.28.546920v1?rss=1 Authors: Micheva, K. D., Gong, B., Collman, F. C., Weinberg, R. J., Smith, S. J., Trimmer, J., Murray, K. D. Abstract: Antibody-based imaging techniques rely on the availability of high-quality reagents whose performance is evaluated for the specific application. Because commercial antibodies are validated for a limited number of uses, in many cases individual laboratories have to employ extensive in-house antibody testing. Here we present a novel strategy to efficiently identify candidate antibodies for array tomography (AT) by introducing an application-specific proxy screening step. AT is a serial section volume microscopy technique that enables quantitative analysis of the cellular proteome in a highly dimensional manner. To identify suitable antibodies for AT-based analysis of synapses in mammalian brain samples, we introduce a heterologous cell-based assay designed to simulate unique features of AT such as chemical fixation and resin embedding that are likely to influence antibody binding. The assay was included as part of the initial screening strategy to generate monoclonal antibodies that can be used for AT. This approach simplifies the screening of candidate antibodies and has high predictive value for identifying antibodies suitable for AT analyses. In addition, we have created a comprehensive database of AT validated antibodies with a neuroscience focus and show that these antibodies have a high likelihood of success for postembedding applications in general, including immunogold electron microscopy. The generation of a large and growing toolbox of antibodies for use in AT will further expand the use of this powerful imaging technique. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Robert C. Hyzy, MD, Professor of Medicine in the Division of Pulmonary and Critical Care at the University of Michigan in Ann Arbor and Medical Director of the Critical Care Medicine Unit at the University of Michigan Hospital presents at Critical Care Grand Rounds with a lecture entitled, "Electrical Impedance Tomography Use in ARDS." 

Antoine GeorgesPhysique de la matière condenséeAnnée 2022-2023Réseaux de neurones, apprentissage et physique quantiqueSéminaire : Juan Carrasquilla - Quantum States with Neural Networks: Representations and TomographyIntervenant(s) :Juan Carrasquilla, Vector Institute, Toronto

Dr. Lew Schon, MD, makes his debut as guest host on CurveBeam AI Cast in an interview with his former fellow, Dr. Cesar de Cesar Netto, MD, PhD. The two reminisce about how Dr. De Netto was first introduced to WBCT imaging at Medstar Union Memorial Hospital in Baltimore, and how he is now a global leader in WBCT research and applications.The two discuss:Dr. de Netto's research into progressive collapsing foot disorder (PCFD) and how WBCT could guide treatment, for example fusion vs. joint preserving procedures.Whether Dr. de Netto thinks all foot & ankle studies will eventually need to be redone using WBCT (spoiler: yes).How Dr. de Netto's patients are specifically seeking him out to assess their foot & ankle pain with WBCT imaging.Click here to read about a research project in which Dr. de Netto's team combined WBCT imaging with coverage mapping and distance mapping to better understand bone positioning in patients with progressive collapsing foot deformity (PCFD).Dr. Cesar de Cesar Netto is an Assistant Professor at the University of Iowa, Carver College of Medicine, specifically in the Department of Orthopedics and Rehabilitation. Dr. de Cesar Netto has had four Clinical Fellowships, including at the University of Sao Paulo, the University of Alabama, the Hospital for Special Surgery in New York, and the Medstar Union Memorial Hospital in Baltimore. He specializes in Foot and Ankle Surgery Disorders and Imaging of the Foot and Ankle, with a focus on Flatfoot Deformity, Tomography and Achilles Tendinopathy.

Commentary by Dr. Valentin Fuster

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.06.531305v1?rss=1 Authors: Bregy, I., Radecke, J., Noga, A., van den Hoek, H., Kern, M., Haenni, B., Engel, B. D., Siebert, C. A., Ishikawa, T., Zuber, B., Ochsenreiter, T. Abstract: In contrast to many eukaryotic organisms, trypanosomes only contain a single mitochondrion per cell. Within that singular mitochondrion, the protist carries a single mitochondrial genome that consists of a complex DNA network, the kinetoplast DNA (kDNA). Segregation of the replicated kDNA is coordinated by the basal body of the cell's single flagellum. The tripartite attachment complex (TAC) forms a physical connection between the proximal end of the basal body and the kDNA. This allows anchoring of the kDNA throughout the cell cycle and couples kDNA segregation with the separation of the basal bodies prior to cell division. Over the past years, several components of the TAC have been identified. To shed light on the structure of the cytoplasmic part of the TAC (known as the exclusion zone), we performed cryo-electron tomography on whole cells. This allowed us to acquire three-dimensional high-resolution images of the exclusion zone in situ. We observed that the exclusion zone filaments offer great mechanical flexibility for basal body movement. We measured the dimensions of the individual structural elements of the area, as well as the overall orientation and positioning of the basal bodies towards the mitochondrial kDNA pocket. Using a combination of experimental data and modelling, we generated a structural model of the exclusion zone protein p197. Our findings suggest that the majority of p197 consists of a string of spectrin-like repeats. We propose that these structural units provide the architecture of a molecular spring and that they are required in the TAC to withstand the mechanical forces generated through basal body repositioning events during kDNA segregation and motility of the organism. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Having industry-changing technology is a good first start, developing partnerships is key, choosing the right people is a must; then putting it all together and beginning to scale is where real leadership comes into play. As the CEO & Co-Founder of Ideon Technologies and being a part of the mining industry for over 25 years nobody understands that better than Gary Agnew. For his second appearance on Mining NOW he discusses how Ideon has now provided services to some of the largest mine operators in the world including BHP, Balboa, Orano, and Glencore. He also showcases the technology advancements and unpacks the process of client collaboration and demand to successfully launch their multiple deploy multiple of borehole muon detectors. Click here to watch.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.03.522627v1?rss=1 Authors: Legal, T., Tong, M., Black, C., Valente-Paterno, M., Gaertig, J., Bui, K. H. Abstract: Cilia are essential organelles that protrude from the cell body. Cilia are made of a microtubule-based structure called the axoneme. In most types of cilia, the ciliary tip is distinct from the rest of the cilium. Here, we used cryo-electron tomography and subtomogram averaging to obtain the structure of the ciliary tip of the ciliate Tetrahymena thermophila. We show the microtubules in the tip are highly cross-linked with each other and stabilised by luminal proteins, plugs and cap proteins at the plus ends. In the tip region, the central pair lacks the typical projections and twists significantly. By analysing cells lacking a ciliary tip-enriched protein CEP104/FAP256 by cryo-electron tomography and proteomics, we discovered candidates for the central pair cap complex and explain potential functions of CEP104/FAP256. These data provide new insights into the function of the ciliary tip and inform about the mechanisms of ciliary assembly and length regulation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.19.517200v1?rss=1 Authors: Kirchweger, P., Mullick, D., Sawin, P. P., Wolf, S. G., Elbaum, M. Abstract: Cryo-electron tomography (cryo-ET) is the prime method for cell biological studies in three dimensions (3D) at high resolution. We have introduced cryo-scanning transmission electron tomography (CSTET), which can access larger 3D volumes, on the scale of 1 micron, making it ideal to study organelles and their interactions in situ. Here we introduce two relevant advances: a) we demonstrate the utility of multi-color super-resolution radial fluctuation light microscopy under cryogenic conditions (cryo-SRRF), and b) we extend the use of deconvolution processing for dual-axis CSTET data. We show that cryo-SRRF nanoscopy is able to reach resolutions in the range of 100 nm, using commonly available fluorophores and a conventional widefield microscope for cryo-correlative light-electron microscopy (cryo-CLEM). Such resolution aids in precisely identifying regions of interest before tomographic acquisition and enhances precision in localizing features of interest within the 3D reconstruction. Dual-axis CSTET tilt series data and application of entropy regularized deconvolution during post-processing results in close-to isotropic resolution in the reconstruction without averaging. We show individual protein densities in a mitochondrion-ER contact in a cell region 850 nm thick. The integration of cryo-SRRF with deconvolved dual-axis CSTET provides a versatile workflow for studying unique objects in a cell. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Data sharing in the ad tech space has largely been a black box system. While it is obvious the data is being collected, the data sharing process is obscure to users. On the show today, Maaz Bin Musa and Rishab, both researchers at the University of Iowa, speak about the importance of data transparency and their tool, ATOM for data transparency. Listen to find out how ATOM uncovers data-sharing relationships in the ad-tech space.

The Journal RETINA is devoted exclusively to diseases of the retina and vitreous. These podcasts are intended to bring to its listeners summaries of selected articles published in the current issue of this internationally acclaimed journal.

The Journal RETINA is devoted exclusively to diseases of the retina and vitreous. These podcasts are intended to bring to its listeners summaries of selected articles published in the current issue of this internationally acclaimed journal.

The Journal RETINA is devoted exclusively to diseases of the retina and vitreous.  These podcasts are intended to bring to its listeners summaries of selected articles published in the current issue of this internationally acclaimed journal.

Commentary by Dr. Hiromasa Otake

The Journal RETINA is devoted exclusively to diseases of the retina and vitreous. These podcasts are intended to bring to its listeners summaries of selected articles published in the current issue of this internationally acclaimed journal.

In this episode, Dr. Joel Schuman gives a detailed overview of how a team of collaborators from diverse academic backgrounds developed Optical Coherence Tomography (OCT), a technology that was a leap forward in the field of Ophthalmology. Dr. Schuman further explores how curiosity lies at the center of his motivation to continue discovering and innovating even after co-developing a breakthrough medical technology. 

In this episode we get into HAARP with returning guest Kevin Reidler. We go into Nikola Tesla and Dr. Bernard Eastlund's patients they used at HAARP. We go into low frequency waves used in Tomography that could potentially be used for mind control. We get into the effects on the human mind, body and immune system Low frequency waves cause. We go into weather modification HAARP causes. We get into earthquakes and Tomography used by HAARP. ALL in all this is a great show. Please subscribe, like, comment and share with a friend. --- Support this podcast: https://anchor.fm/josh-monday/support