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News, Prague Pride kicks off, Czech Centres overhaul, 700-year-old statue undergoes tomography at a Brno hospital, trip to Divoká Šárka on the suburbs of Prague
Three years after his first appearance, Butterfly Network CEO Joe DeVivo returns to catch Harry up on the roadmap. Butterfly's ultrasound-on-a-chip has evolved from a single handheld device into a foundational semiconductor platform that third parties can build on. The most dramatic example: Midjourney's full-body scanner, which rings 40 Butterfly chips around the body for whole-body tomographic imaging. Joe and Harry dig into what's real today versus what's coming, the physics of ultrasound, the path from demo to FDA clearance, and the business logic of "multiple shots on goal." In this episode: The chip as a platform: opening Butterfly's technology to third-party developers (the "Nvidia moment"). Midjourney's full-body scanner: tomography, 400 teraflops of data, and a roadmap toward a one-minute scan with the Apollo chip. Real-world impact: 1,500 midwives trained in Kenya and South Africa, plus a new FDA-cleared gestational-age AI tool. Partners beyond Midjourney: vascular robotics, fatty liver diagnosis, and brain-computer interfaces (including "silent speech"). Physics Q&A: why 360-degree imaging solves ultrasound's problems with air and bone. The hospital shift: capturing "ghost" scans, Compass AI, and at-risk skilled-nursing deployments. The 10-year vision: imaging that comes to the patient instead of the patient going to imaging. Chapters: (00:01) A roadmap from three years ago (00:31) Midjourney unveils a full-body scanner (01:31) Joe DeVivo returns (02:59) What shipped: the chip becomes foundational (04:52) Opening the platform to third parties (06:34) Kenya and South Africa: midwives and the FDA-cleared gestational-age app (11:11) FDA rigor and validating AI (14:52) Butterfly Garden, Butterfly Embedded, and the nine partners (16:53) Brain-computer interfaces and silent speech (22:00) The Midjourney deal: origin and reaction (24:03) Tomography explained (28:12) What 40 chips can see and the data challenge (29:33) The roadmap to a one-minute scan; the Apollo chip (32:43) AI looking for a physical carrier (34:31) Prototype to product: milestones to clearance (38:28) Wellness first, then regulatory clearances (39:03) The physics of air and bone (41:45) The investment thesis: multiple shots on goal (46:26) The business today: Compass AI and health-system deployments (49:54) Heart-failure monitoring and at-risk skilled nursing (53:49) The 10-year view: imaging comes to the patient (57:18) Why early detection matters (59:50) Closing About the guest: Joe DeVivo is CEO of Butterfly Network and has spent 35 years in medical devices. Also mentioned: Harry's book, The Invisible Interface: How AI Turns Intentions into Actions and Who Wins (foreword by Don Norman), available in print and ebook.
Send a textIn this episode, we sit down with Dr. Jessica Shui, attending neonatologist at Mass General for Children, to explore the game-changing potential of Electrical Impedance Tomography (EIT) in the NICU. We dive into her recent paper in the Journal of Perinatology on using non-invasive EIT to identify optimal PEEP in infants with severe bronchopulmonary dysplasia. Dr. Shui explains how this real-time, radiation-free technology allows clinicians to visualize lung mechanics, dynamically titrate ventilator settings, and confidently reduce PEEP without risking atelectasis. Join us as we discuss moving beyond blind adjustments and stepping into the future of personalized neonatal respiratory care. Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!
SpaceTime with Stuart Gary | Astronomy, Space & Science News
In this episode of SpaceTime, we dive into groundbreaking research revealing the true composition of the Earth's core, explore new insights into solar neutrinos, and uncover the complexities of Martian volcanoes.Earth's Core Contains Vast Hydrogen ReservoirA recent study published in Nature Communications indicates that Earth's core may hold up to 45 oceans' worth of hydrogen, challenging the long-held belief that water on our planet primarily came from asteroids and comets. Utilizing advanced laboratory techniques, researchers simulated the extreme conditions of the core to uncover its surprising hydrogen content, suggesting a significant internal source of water far beyond previous estimates.Neutrinos from the Sun's CoreA new dark matter experiment has successfully detected neutrinos originating from the Sun's core, marking a significant milestone in our understanding of these elusive particles. The LZ experiment at the Sanford Underground Research Facility captured signals from Brian 8 solar neutrinos, providing valuable data on solar processes and setting new limits for dark matter research. This breakthrough highlights the potential of neutrino studies in unraveling the mysteries of both dark matter and stellar dynamics.Complexity of Martian VolcanoesNew findings published in Geology reveal that young Martian volcanoes are far more complex than previously thought. Researchers have discovered that these volcanoes were shaped by long-lasting and evolving magma systems rather than single eruptions. By analyzing surface features and mineral compositions from orbit, scientists have reconstructed the intricate eruptive history of these volcanic systems, shedding light on the Red Planet's geological past.www.spacetimewithstuartgary.com✍️ Episode ReferencesNature Communications, GeologyBecome a supporter of this podcast: https://www.spreaker.com/podcast/spacetime-with-stuart-gary--2458531/support.(00:00:00) New study reveals Earth's core may contain vast amounts of hydrogen(00:08:30) Breakthrough in solar neutrino detection from the Sun's core(00:16:45) Insights into the complex eruptive history of Martian volcanoes(00:25:00) Science report: The link between caffeine consumption and reduced dementia risk(00:32:15) Study on the frequency of passionate love experiences in humans
In this episode of the Heart podcast, Digital Media Editor, Professor James Rudd, is joined by Prof. Filippo Cademartiri from Naples, Italy. They discuss all aspects of this emerging CT technology that promises lower radiation imaging, with higher resolution and excellent in-stent imaging, but at a significant cost in terms of hardware. If you enjoy the show, please leave us a positive review wherever you get your podcasts. It helps us to reach more people - thanks! Link to published paper: https://heart.bmj.com/content/early/2025/05/14/heartjnl-2025-325790
Listen to opticians discuss the newest eye care and eye health technologies, which are fighting rising eye health issues like myopia and helping patients of all ages, including children, see well. Learn more at https://www.theeyecube.com/ The Eye Cube City: London Address: 256 West End Lane, West Hampstead, NW6 1LJ Website: https://www.theeyecube.com/
This week's special guest, Andi Hektor, takes us on a deep dive into his journey from academia to entrepreneurship, how GScan is tackling critical infrastructure challenges, and why he chose Cambridge as the company's UK base.GScan is pioneering Muon tomography, an advanced scanning technology originally used for border security but now revolutionising non-destructive testing (NDT) in construction. The technology helps detect corrosion and structural weaknesses in bridges and buildings, preventing costly and environmentally harmful demolitions. “Bridges are often demolished as a precaution because engineers can't see inside them. We provide that visibility, potentially doubling their lifespan.”Initially setting up in London, Andi quickly realised Cambridge's startup ecosystem was the ideal home for GScan: “London's tech scene is great, but for deep tech, it's easy to get lost. In Cambridge, you can build a network fast. The Bradfield Centre has been amazing.” Hosted on Acast. See acast.com/privacy for more information.
Adrian Mendes, CEO of Perimeter Medical Imaging AI, is solving the problem of margin assessment in cancer surgery. Surgeons often have to perform a second surgery on breast cancer patients because they are unable to completely remove all of the cancerous cells the first time. The company has developed Optical Coherence Tomography (OCT) imaging technology that allows surgeons to see cells at a microscopic level in real-time during surgery, helping them remove the tumor and all surrounding cancerous tissue. Adrian explains, "The surgeon is trying to ensure that when they extract the tumor and the cancer, there is a margin of healthy cells around it. Studies have shown that if they can achieve that, and with breast cancer, that margin needs to be two millimeters generally, then the likelihood of them having left cancer cells back in the body goes down drastically. This is every surgeon's objective for cancer treatment. We help the surgeons ensure that they've achieved what they call clean margins." "Yes, it's quite significant. So, for breast cancer surgery alone, it's about one in every five surgeries are unsuccessful because the margins aren't clean, and then the patient has to come back for a second surgery. So, there are about 300,000 breast cancer surgeries per year in the United States. If you think about 20% of that, there are a lot of women that are having to go back for a second surgery every year. That's just in the United States. And it's a global problem." "What's unique about our technology is we use an imaging tech called OCT or Optical Coherence Tomography that allows images to be created down at around 15-micron width level. And that's small enough to be able to distinguish cells. And so with that, it just gives the surgeon so much more ability to see what they're looking at." "The next generation uses the same imaging modality, the OCT imaging, but it adds an artificial intelligence and AI layer to it. So what we've done is trained an AI algorithm to recognize suspicious areas inside images of breast tissue. And these suspicious areas are indicative of cancer. The way we train the model is we have a library of about 2 million images of breast tissue, both cancerous and healthy tissue, and we've got labels that have been provided by pathologists." #PerimeterMedical #Oncology #BreastCancerSurgery #OCT #Tumors #MedAI perimetermed.com Download the transcript here
Adrian Mendes, CEO of Perimeter Medical Imaging AI, is solving the problem of margin assessment in cancer surgery. Surgeons often have to perform a second surgery on breast cancer patients because they are unable to completely remove all of the cancerous cells the first time. The company has developed Optical Coherence Tomography (OCT) imaging technology that allows surgeons to see cells at a microscopic level in real-time during surgery, helping them remove the tumor and all surrounding cancerous tissue. Adrian explains, "The surgeon is trying to ensure that when they extract the tumor and the cancer, there is a margin of healthy cells around it. Studies have shown that if they can achieve that, and with breast cancer, that margin needs to be two millimeters generally, then the likelihood of them having left cancer cells back in the body goes down drastically. This is every surgeon's objective for cancer treatment. We help the surgeons ensure that they've achieved what they call clean margins." "Yes, it's quite significant. So, for breast cancer surgery alone, it's about one in every five surgeries are unsuccessful because the margins aren't clean, and then the patient has to come back for a second surgery. So, there are about 300,000 breast cancer surgeries per year in the United States. If you think about 20% of that, there are a lot of women that are having to go back for a second surgery every year. That's just in the United States. And it's a global problem." "What's unique about our technology is we use an imaging tech called OCT or Optical Coherence Tomography that allows images to be created down at around 15-micron width level. And that's small enough to be able to distinguish cells. And so with that, it just gives the surgeon so much more ability to see what they're looking at." "The next generation uses the same imaging modality, the OCT imaging, but it adds an artificial intelligence and AI layer to it. So what we've done is trained an AI algorithm to recognize suspicious areas inside images of breast tissue. And these suspicious areas are indicative of cancer. The way we train the model is we have a library of about 2 million images of breast tissue, both cancerous and healthy tissue, and we've got labels that have been provided by pathologists." #PerimeterMedical #Oncology #BreastCancerSurgery #OCT #Tumors #MedAI perimetermed.com Listen to the podcast here
Interview with Benjamin K. Young, MD, MS, author of Ultra-Widefield Optical Coherence Tomography Beyond the Ora Serrata in Retinopathy of Prematurity. Hosted by Neil M. Bressler, MD. Related Content: Ultra-Widefield Optical Coherence Tomography Beyond the Ora Serrata in Retinopathy of Prematurity
Interview with Benjamin K. Young, MD, MS, author of Ultra-Widefield Optical Coherence Tomography Beyond the Ora Serrata in Retinopathy of Prematurity. Hosted by Neil M. Bressler, MD. Related Content: Ultra-Widefield Optical Coherence Tomography Beyond the Ora Serrata in Retinopathy of Prematurity
OCCUPI – Optical Coherence Tomography-Guided Coronary Intervention in Patients with Complex Lesions
Entrevista a Miguel Vidal, cofundador de North Tomography
Entrevista a Miguel Vidal, cofundador de North Tomography
Commentary by Dr. Candice Silversides
Ettore Biondi, California Institute of Technology Traveltime-based tomographic methods have been extensively explored and employed by researchers since the 80s. Such algorithms have been successfully applied to various geophysical applications, ranging from seismic exploration to global to regional seismological scales. However, given the advancements in computational architectures over the last 20 years, full-waveform methodologies are now dominating most of the subsurface-parameter inversion applications. These workflows seek to match all the waveforms present within active seismic data or synthetic Green’s functions obtained by cross-correlating ambient noise. Despite this decrease in the popularity of traveltime-based tomographic approaches, these methods have great potential to be successful when applied to distributed acoustic sensing (DAS) data for seismic applications. DAS instruments can operate on existing telecommunication fibers and transform them into large-scale high-resolution seismic arrays. We demonstrate such potential by applying an Eikonal traveltime double-difference tomography algorithm to DAS data recorded in the Long Valley caldera, located in the Eastern Sierra region of California. This active volcanic area has been extensively studied in the last 50 years and its recent unrest remains still poorly understood. We employ two DAS arrays composed of almost 9000 channels along a 90-km north-south transect across the caldera to characterize the subsurface structures present underneath the area. We use almost 2000 cataloged events and apply a machine-learning algorithm to accurately pick their P and S arrival times necessary for the tomography. The range and spatial resolution of the DAS arrays allow us to retrieve structures that could not be resolved by previous studies that employed only conventional station recordings. Our results agree well with previous studies and highlight the presence of a low-velocity basin along the Mono-Inyo craters. Both P- and S-wave models also show a low-velocity structure centered below Mono Lake, which agrees with historical gravity surveys. Moreover, the low Vp/Vs ratio inverted below the Long Valley caldera suggests a lack of newly intruded materials at depth above 10 km and a clear separation between the shallow low-velocity basins and the ≥10-km deep magmatic reservoir.
BestPodcastintheMetaverse.com Canary Cry News Talk #742 05.20.2024 - Recorded Live to 1s and 0s GREENE FIREBALLS | Congress Chaos, Iran President, Nephilim Bird Flu Deconstructing Corporate Mainstream Media News from a Biblical Worldview Declaring Jesus as Lord amidst the Fifth Generation War! TJT Youtube (backup) Channel: https://www.youtube.com/@TheJoyspiracyTheory The Show Operates on the Value 4 Value Model: http://CanaryCry.Support Join the Supply Drop: https://CanaryCrySupplyDrop.com Submit Articles: https://CanaryCry.Report Submit Art: https://CanaryCry.Art Join the T-Shirt Council: https://CanaryCryTShirtCouncil.com Podcasting 2.0: https://PodcastIndex.org Resource: Index of MSM Ownership (Harvard.edu) Resource: Aliens Demons Doc (feat. Dr. Heiser, Unseen Realm) Resource: False Christ: Will the Antichrist Claim to be the Jewish Messiah Tree of Links: https://CanaryCry.Party Join the Canary Cry Roundtable This Episode was Produced By: Executive Producers Sir LX Protocol V2 Knight of the Berrean Protocol*** Sir Jamey Not the Lanister*** Producers of Treasure Roderick B, Sir Marti K Knight of the Wrong Timeline, Elle O, Sir Scott Knight of Truth, DrWhoDunDat, Misses TinFoilHatMan, Dame Gail, Veronica D, Sir Casey the Shield Knight CanaryCry.ART Submissions JonathanF, Little Owen, Sir Marti K CONTENT PRODUCTION (Microfiction etc.) Stephen S - Lone Scum, CEO of BuyMyTek commented on the viral video of Bawsten Dynamics' humanoid robot, “That's pretty disturbing; that will scare children and pets. We need to be more pet friendly. Add puppy dog eyes and purring.” JOLMS - Reading no response from the pilot, the P.A.D. determined that the reports from the flight deck's onboard instruments were founded and thereby accepted the emergency level 1 clearance. It turns to read the HUD.On the left window are planetary statistics. Weather, Power, Tomography and Topology scans Etc Etc. (Out of date). The window below held more personal features. An [ envelope ] icon. A [calendar] icon, (bla bla bla) Then curiously… a [ Wireless signal ] icon. Crossed out. ‘Huh' PAD wondered. TIMESTAMPERS Jade Bouncerson, Morgan E CanaryCry.Report Submissions JAM REMINDERS Clankoniphius SHOW NOTES/TIMESTAMPS Podcast T- 07:45 PreShow Prayer from Basil: 07:46 V / 00:01 P HELLO, RUN DOWN 11:51 V / 04:06 P RACE WARS/POLYTICK 13:51 V / 06:06 P Clip: MTG vs AOC vs Crocket Clip: The crucial moment from Rep. Crockett, MTG's heated exchange (MSNBC) SPACE/BIBLICAL 39:50 V / 32:05 P Bright green fireball lights up the skies over Portugal and Spain (Space.com) Clip: Meteor over Portugal DAY JINGLE/V4V/EPs/TREASURE 48:49 V / 41:04 P FLIPPY/BEING WATCHED 01:13:36 V / 01:05:51 P Flippy in Space! Helping astronauts recover form embarrassing falls. (Robot Report) WW3 01:23:52 V / 01:16:07 P Clip: Iran's President Raisi killed in helicopter crash (CNN) → Naftali X posts 1, 2, Clip 3 Slav Prime Minister Gunned Down in Politically Motivated attack (CNN) TALENT/TIME/TREASURE 02:01:42 V / 01:53:57 P ANTARCTICA/BIRD FLU 02:18:26 V / 02:10:41 P Bird Flu haws BREACHED remote Antarctica (ABC) US post influenza A wastewater data online to assist bird flu probe, official (Reuters) 2 possible bird flu vaccines could be available within weeks, if needed (NBC News) Bird Flu Engineered to Infect Humans Could Be Lab-Produced ‘in Months,' (PJ Media) OUTRO 02:37:27 V / 02:29:42 P END
Fractional Flow Reserve or Optical Coherence Tomography to Guide the Management of Patients with Angiographically Intermediate Coronary Stenosis
Dr. David Huang joins the show to share his story of developing optical coherence tomography (OCT), for which he, Dr. James Fujimoto, and Eric Swanson won the National Medal of Technology, the highest award for innovators in the United States, as well as the 2023 Lasker–DeBakey Clinical Medical Research Award, often called "America's Nobel Prize." For all episodes or to claim CME credit for selected episodes, visit www.aao.org/podcasts.
Commentary by Dr. Valentin Fuster
Matthew Silva, PhD, CEO of EMIT Imaging, answers questions from a recent webinar where he highlights the role of cryo-fluorescence tomography in advancing the field of immunotherapy research.
Matthew Silva, PhD, CEO of EMIT Imaging, answers questions from a recent webinar where he highlights the role of cryo-fluorescence tomography in advancing the field of immunotherapy research.
Understanding Semiconductors: Modern Metrology from Lab to Fab
Ever wondered how atom probe tomography advances our understanding of semiconductors and improves device performance?In today's episode, we dive deep into the world of semiconductors as we explore the fascinating realm of atom probe tomography. Our guest expert, David Larson, sheds light on the intricacies of this powerful materials characterization technique. From minimizing damage and improving yield to overcoming challenges in data reconstruction, David shares insights on the latest advancements and future possibilities in the field. Tune in to gain a deeper understanding of semiconductors and atom probe technology's role in their analysis.Join us as we discuss the following:The use of a Focused Ion Beam (FIB) at liquid nitrogen temperature to minimize damage and improve yieldChallenges of yield and spatial distortion in atom probe technologyHow different laser wavelengths can enhance reconstruction and yield in heterogeneous structuresHow modeling and in situ measurements play a crucial role in predicting the field of operationThe limitations, growth, and future improvements of atom probe technology, including its application in analyzing real devicesContact Markus Kuhn on LinkedIn for any potential guest requests or episode ideas.To ensure you never miss an episode of the Understanding Semiconductor podcast, subscribe to Apple Podcasts, Spotify, Google, or our website. Listening on a desktop & can't see the links? Just search for Understanding Semiconductors in your favorite podcast player.
Optical coherence tomography (OCT) is a powerful imaging tool used across multiple clinical disciplines. JAMA Executive Editor Gregory Curfman, MD, speaks with 2023 Lasker Award recipient James G. Fujimoto, PhD, professor of electrical engineering at MIT, about his role in developing OCT and OCT's advancements in clinical practice. Related Content: Optical Coherence Tomography—History, Evolution, and Future Prospects
Commentary by Dr. Valentin Fuster
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.03.551868v1?rss=1 Authors: Lin, Z., Zhang, X., Nandi, P., Lin, Y., Wang, L., Chu, Y., Paape, T., Yang, Y., Xiao, X., Liu, Q. Abstract: X-ray tomography and x-ray fluorescence imaging are two non-invasive imaging techniques to study cellular structures and chemical element distributions, respectively. However, correlative X-ray tomography and fluorescence imaging for the same cell has yet to be routinely realized due to challenges in sample preparation and X-ray radiation damage. Here we report an integrated experimental and computational workflow for achieving correlative multi-modality X-ray imaging of a single cell. The method consists of the preparation of radiation-resistant single-cell samples using live-cell imaging-assisted chemical fixation and freeze-drying procedures, targeting and labeling cells for correlative x-ray tomography and x-ray fluorescence measurement, and computational reconstruction of the correlative and multi-modality images. With X-ray tomography, cellular structures including the overall structure and intracellular organelles are visualized, while X-ray fluorescence imaging reveals the distribution of multiple chemical elements within the same cell. Our correlative method demonstrates the feasibility and broad applicability of using X-rays to understand cellular structures and the roles of multiple chemical elements and related proteins in signaling and other biological processes. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.16.549168v1?rss=1 Authors: Schrad, J. R., Fu, G., Hable, W. E., Tayar, A. M., Oliveira, K., Nicastro, D. Abstract: Cilia and flagella play a crucial role in the development and function of most eukaryotic organisms. The structural core of the flagellum, the axoneme, is conserved in most eukaryotes and careful regulation of dynein motors within the axoneme is required for proper ciliary beating. The sperm flagellum from the American eel (Anguilla rostrata) has been shown to lack many of the canonical axonemal proteins, including the radial spokes, the central pair complex, and possibly even the outer row of dynein arms, presenting a "minimal" flagellar system. Here, we present cryo-electron tomography analysis of the eel sperm flagellum. We identified two states for the eel sperm flagellum within our tomograms, narrow and wide, and found that the flagellum started narrow near the sperm head and widened distally. Subtomogram averages revealed that the eel sperm flagellum has retained remnants of the missing regulatory complexes, including a short radial spoke 3 complex, basal components of radial spokes 1 and 2, and an outer dynein arm docking complex. We also describe unique structural features of the A. rostrata sperm flagellum, such as a unique pattern of holes at the inner junction and an accessory complex located at the "outer" junction. Finally, we discuss the consequences of losing key regulatory factors for the eel sperm flagellum and hypothesize several evolutionary factors that may have led to their loss. Together, our results shed light onto the structure and function of the eel sperm axoneme and provide insight into the minimum requirements for proper ciliary beating. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.12.547497v1?rss=1 Authors: Kislinger, G., Fabig, G., Wehn, A. C., Rodriguez, L., Jiang, H., Niemann, C., Klymchenko, A. S., Plesnila, N., Misgeld, T., Mueller-Reichert, T., Khalin, I., Schifferer, M. Abstract: Like other volume electron microscopy approaches, Automated Tape Collecting Ultramicrotomy (ATUM) enables imaging of serial sections deposited on thick plastic tapes by scanning electron microscopy (SEM). However, ATUM is unique by enabling hierarchical imaging and thus efficient screening for target structures as needed e.g., for correlated light and electron microscopy. However, SEM of sections on tape can only access the section surface, thereby limiting the axial resolution to the typical size of cellular vesicles, an order of magnitude lower than the acquired xy resolution. In contrast, serial-section electron tomography (ET), a transmission electron microscopy-based approach, yields isotropic voxels at full EM resolution, but requires deposition of sections on electron-permeant thin and fragile monolayer films - thus making screening of large section libraries difficult and prone to section loss. To combine the strength of both approaches, we developed ATUM-Tomo, a hybrid method, where sections are first reversibly attached to plastic tape via a dissolvable coating, and after screening detached and transferred to the ET-compatible thin films. Thus, ATUM-SEM of serial semi-thick sections and consecutive ET of one selected section combines SEM's fast target recognition and coarse rendering capability with ET's high-resolution volume visualizations - thus enabling multi-scale interrogation of cellular ultrastructure. As a proof-of-principle, we applied correlative ATUM-Tomo to study ultrastructural features of blood brain barrier (BBB) leakiness around microthrombi in a mouse model of traumatic brain injury. Microthrombi and associated sites of BBB leakiness were identified by confocal imaging of injected fluorescent and electron-dense nanoparticles, then relocalized by ATUM-SEM, and finally interrogated by correlated ATUM-Tomo, a workflow which created a seamless zoom-in on structural BBB pathology from the micro- to the nanometer scale. Overall, our new ATUM-Tomo approach will substantially advance ultrastructural analysis of biological phenomena that require cell- and tissue-level contextualization of the finest subcellular textures. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.28.546920v1?rss=1 Authors: Micheva, K. D., Gong, B., Collman, F. C., Weinberg, R. J., Smith, S. J., Trimmer, J., Murray, K. D. Abstract: Antibody-based imaging techniques rely on the availability of high-quality reagents whose performance is evaluated for the specific application. Because commercial antibodies are validated for a limited number of uses, in many cases individual laboratories have to employ extensive in-house antibody testing. Here we present a novel strategy to efficiently identify candidate antibodies for array tomography (AT) by introducing an application-specific proxy screening step. AT is a serial section volume microscopy technique that enables quantitative analysis of the cellular proteome in a highly dimensional manner. To identify suitable antibodies for AT-based analysis of synapses in mammalian brain samples, we introduce a heterologous cell-based assay designed to simulate unique features of AT such as chemical fixation and resin embedding that are likely to influence antibody binding. The assay was included as part of the initial screening strategy to generate monoclonal antibodies that can be used for AT. This approach simplifies the screening of candidate antibodies and has high predictive value for identifying antibodies suitable for AT analyses. In addition, we have created a comprehensive database of AT validated antibodies with a neuroscience focus and show that these antibodies have a high likelihood of success for postembedding applications in general, including immunogold electron microscopy. The generation of a large and growing toolbox of antibodies for use in AT will further expand the use of this powerful imaging technique. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Robert C. Hyzy, MD, Professor of Medicine in the Division of Pulmonary and Critical Care at the University of Michigan in Ann Arbor and Medical Director of the Critical Care Medicine Unit at the University of Michigan Hospital presents at Critical Care Grand Rounds with a lecture entitled, "Electrical Impedance Tomography Use in ARDS."
Antoine GeorgesPhysique de la matière condenséeAnnée 2022-2023Réseaux de neurones, apprentissage et physique quantiqueSéminaire : Juan Carrasquilla - Quantum States with Neural Networks: Representations and TomographyIntervenant(s) :Juan Carrasquilla, Vector Institute, Toronto
Commentary by Dr. Valentin Fuster
Data sharing in the ad tech space has largely been a black box system. While it is obvious the data is being collected, the data sharing process is obscure to users. On the show today, Maaz Bin Musa and Rishab, both researchers at the University of Iowa, speak about the importance of data transparency and their tool, ATOM for data transparency. Listen to find out how ATOM uncovers data-sharing relationships in the ad-tech space.
The Journal RETINA is devoted exclusively to diseases of the retina and vitreous. These podcasts are intended to bring to its listeners summaries of selected articles published in the current issue of this internationally acclaimed journal.
The Journal RETINA is devoted exclusively to diseases of the retina and vitreous. These podcasts are intended to bring to its listeners summaries of selected articles published in the current issue of this internationally acclaimed journal.
The Journal RETINA is devoted exclusively to diseases of the retina and vitreous. These podcasts are intended to bring to its listeners summaries of selected articles published in the current issue of this internationally acclaimed journal.
Commentary by Dr. Hiromasa Otake
The Journal RETINA is devoted exclusively to diseases of the retina and vitreous. These podcasts are intended to bring to its listeners summaries of selected articles published in the current issue of this internationally acclaimed journal.
In this episode, Dr. Joel Schuman gives a detailed overview of how a team of collaborators from diverse academic backgrounds developed Optical Coherence Tomography (OCT), a technology that was a leap forward in the field of Ophthalmology. Dr. Schuman further explores how curiosity lies at the center of his motivation to continue discovering and innovating even after co-developing a breakthrough medical technology.
In this episode we get into HAARP with returning guest Kevin Reidler. We go into Nikola Tesla and Dr. Bernard Eastlund's patients they used at HAARP. We go into low frequency waves used in Tomography that could potentially be used for mind control. We get into the effects on the human mind, body and immune system Low frequency waves cause. We go into weather modification HAARP causes. We get into earthquakes and Tomography used by HAARP. ALL in all this is a great show. Please subscribe, like, comment and share with a friend. --- Support this podcast: https://anchor.fm/josh-monday/support