Podcasts about synapses

Send us Fan MailHow genomics is used to study what makes a human brain, and how genetically damaged neurons get removed.TOPICS DISCUSSED:Scale & Size: A human brain is about three times a chimpanzee brain by mass, but the larger change is extra association cortex and extra upper-layer circuits that talk mostly to other cortex.When Development Ends: Most cortical neurons are born before birth. Myelin and other glia keep forming into the twenties. Synapses keep changing after that.Broken Genomes Get Edited: Walsh describes forthcoming work in which ~25–30% of late-fetal cortical neurons carry genetic defects, falling to ~5% by birth, with smaller defects still being removed through adult life.Regulation vs. New Genes: Humans and mice both have ~20,000 genes. Most human-specific change is in when and where those genes turn on, not in inventing new proteins.Human Accelerated Regions: About half of HARs involve the brain. Rare mutations in them show up more often in kids with intellectual disability and autism.ASPM & Microcephaly: Loss of one conserved cell-division gene can shrink a human brain toward chimpanzee volume and shape. The same knockout barely shrinks a mouse.Heritability of Genetic Disorders: Autism is highly heritable in twin studies. A whole-genome test today still finds a specific cause in only about a quarter to a third of kids.Support the showSupport my work:Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.For all the ways you can support my efforts.

DZ Kalman, fellow at the Berkman Klein Center, research fellow at the Shalom Hartman Institute, senior advisor at Sinai & Synapses, and host of Belief in the Future, joins Kevin Frazier, AI Innovation and Law Fellow at the University of Texas School of Law and a Senior Editor at Lawfare, to explore what religious traditions can teach AI governance.DZ and Kevin discuss religious responses to AI, Jewish technoculture, kosher supervision as a model for AI certification, and the limits of AI use in faith contexts. They also connect these traditions to contemporary debates about alignment, institutional trust, human dignity. Hosted on Acast. See acast.com/privacy for more information.

If you're up for a challenge and love a good brain teaser, come check out some Math Riddles That Will Scramble Your Synapses. These puzzles are perfect for testing your problem-solving skills and giving your brain a serious workout. Whether you're a math whiz or just looking for some fun, these riddles are sure to keep you on your toes. Dive in and see how many you can solve! Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode 141 In part 32 of our Sinai and Synapses interview series, we are talking to Dr. Hannah Giunta-Stibb. She is a neonatologist and pediatric pulmonologist at Nationwide Children's Hospital in Columbus, OH. In addition to her clinical work, Hannah has a PhD in bioethics and does research on critical decision-making and family communication.    Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

Episode 142 In part 33 of our Sinai and Synapses interview series, we are talking to The Rev. Dr. Denise Yarbrough. She is an ordained Episcopal priest with over two decades of dedicated experience in interreligious engagement. She recently retired from the University of Rochester, where she served as the director of religious and spiritual life. In that role, she oversaw the interfaith chapel, guided student groups, and taught religion courses centered on interreligious dialogue and the intersection of public health and religion.    Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

Episode 140 In part 31 of our Sinai and Synapses interview series, we are doing a different sort of thing. Today, we have the privilege of speaking with Rev. Dr. Katie Givens Kime who is the CEO of the Alliance for Christian Media and Exec. Producer of Day1 broadcasting. Joining us as well is the founding director of Sinai and Synapses, the Rabbi Geoff Mitelman. We wanted to get the three of us together to talk a little about the changing landscapes of media, communication, and how we make meaningful content in this algorithmically obsessed world. The resulting conversation was uplifting, inspiring, insightful, and at times surprisingly hilarious.    Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

This week, host Sam Ko goes upstream from our usual clinical and business topics to sit down with Dr. Roberto Malinow, emeritus professor at UC San Diego, member of both the National Academy of Sciences and the National Academy of Medicine, and one of the world's leading researchers on synaptic plasticity and NMDA receptor biology. His work has been cited more than 30,000 times, and his recent perspective piece takes a very different view of what's actually happening during a ketamine infusion.The core of this conversation is his hypothesis that ketamine works by selectively weakening hyperactive brain circuits, but only the ones actively firing while the drug is on board. It's a finding that raises some genuinely uncomfortable questions about the standard set and setting approach, and points to chronic pain treatment as a practical place to start testing these ideas clinically.You'll also hear about the brain's "disappointment center," the lateral habenula, and why it may be hyperactive in depression, the Stanford anesthesia study and what it suggests about brain activity during treatment, and a wide ranging look at consciousness, optogenetics, the gut-brain connection, and what basic science still doesn't fully understand about how psychiatric drugs work.What You'll Learn in This Episode· Revolutionary ketamine mechanism - How Dr. Malinow's hypothesis suggests ketamine works by weakening hyperactive brain circuits, but only when those specific circuits are actively firing during treatment· The disappointment center concept - Understanding the lateral habenula as the brain's disappointment center that inhibits dopamine and may be hyperactive in depression, serving an evolutionary purpose in reinforcement learning· Challenge to set and setting orthodoxy - How activating negative thoughts or painful experiences could possibly enhance therapeutic outcomes· Neuroplasticity fundamentals - How synapses can be rapidly modified and why NMDA receptors are crucial for both strengthening and weakening neural pathways, forming the basis for learning and memory· Rapid vs. delayed therapeutic effects - Why ketamine can work almost immediately while traditional antidepressants take weeks, and what this reveals about different mechanisms of action· Chronic pain treatment implications - How activating pain circuits during ketamine infusions might be more effective than current protocols, and why chronic pain could be the ideal testing ground for this hypothesis· Basic science translation - How laboratory findings about synaptic plasticity and NMDA receptors connect to real-world therapeutic applications in depression, PTSD, and pain management· Optogenetics technology - How scientists can now deliver light-sensitive proteins to specific neurons, allowing precise activation or inactivation of brain circuits to study behavior and memory· Memory manipulation research - Fascinating studies showing how specific memories can be turned on and off using targeted brain stimulation, with implications for trauma and addiction treatment· Consciousness and synaptic function - Exploring the complex relationship between individual neurons and higher-order brain functions, and why bridging these levels remains challengingEpisode 59 show notes:00:00:00 Teaser: Those hyperactive circuits…00:00:24 Episode Introduction and Guest Overview00:01:12 Sam Introduces and Welcomes Dr. Roberto Malinow00:02:41 Background: From Reed College to The MD/PhD Path00:05:17 Why Basic Science Won Out Over Clinical Medicine00:06:06 The Lecture That Started It All: Professor Rodolfo Llinás and Synapses00:06:51 How Ketamine Interacts with the NMDA Receptor00:07:47 The "Disappointment Center": What the Lateral Habenula Does and Why It Matters in Depression00:09:16 The Standard Set and Setting Approach in Outpatient Ketamine Clinics00:10:12 The Three-Part Hypothesis: Neuroplasticity, Hyperactive Circuits, and Negative Thoughts00:11:49 Written Exposure Therapy and PTSD: Priming Circuits Before the Infusion00:12:53 Chronic Pain as the Easier Testing Ground for the Hypothesis00:14:20 Activating the Pain Pathways During a Ketamine Infusion00:17:23 The Anesthesia Study (Heifets/Stanford): Why the Brain Needs to Be Active00:18:48 What Would a Human Study Design Actually Look Like?00:20:41 Animal Study Evidence Supporting the Active-Stimulus Hypothesis00:21:33 Zooming Out: Synapses, Consciousness, and the Shakespeare Analogy00:23:18 Optogenetics Explained: Using Light to Control Specific Neurons00:27:31 What Don't We Understand About Depression?00:28:29 Lateral Habenula in Animal Depression Models and Dr. Malinow's Own Experiments00:29:13 The Dystopian Scenario: Using Ketamine-Like Drugs to Wipe Out Ideas00:31:31 Common Misconceptions Clinicians Have About Synapses00:32:47 What Surprised Dr. Malinow Most About Studying Synapses00:35:15 Why Ketamine Works Rapidly While SSRIs Take Weeks00:37:30 The "Party Trick": Learning Is Neuroplasticity in Real Time00:39:13 NMDA Receptors and Their Role in Learning and Memory00:39:47 Optogenetics Research: Turning Fear Memories On and Off in Animals00:42:08 Glutamate: 90% of Synaptic Transmission Explained00:43:55 Synapses in the Gut: The Enteric Nervous System00:45:58 The Gut-Brain Connection and Future Research00:46:23 Papers Worth Reading in the Ketamine Space00:47:50 The Psychedelic Renaissance: Psilocybin, the Disappointment Center, and What's Next00:50:20 Could the Activation Hypothesis Apply to Psilocybin and MDMA as Well?00:52:57 Rapid-Fire Questions Begin00:53:19 Time Travel00:54:19 Hidden Talent00:54:48 Alternate Career00:55:42 Advice to 18-Year-Old Roberto00:56:29 Final Thoughts and Call to Action for Clinicians00:57:00 Where to Find Dr. Malinow's Research (UCSD Website)00:57:40 Sam's Closing Remarks00:58:32 Episode EndingThanks for listeningConnect with Dr. Malinow:Website: https://biology.ucsd.edu/research/faculty/rmalinowEmail: rmalinow@ucsd.edu

Episode 139 In part 30 of our Sinai and Synapses interview series, we are talking with Dr. Olapeju Simoyan. She is an addiction medicine physician and an adjunct professor in the Department of Psychiatry at Drexel University College of Medicine. She also holds adjunct faculty positions at Penn State University College of Medicine and Geisinger Commonwealth School of Medicine. She is also an author and photographer, seeking to make both science and faith relatable to people of all ages.   Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

Episode 138 In part 29 of our Sinai and Synapses interview series, we are talking with Dr. David Adler Gold. He is a geobiologist, combining genetics and the fossil record to study the relationship between Earth and life over long timescales. He has worked on problems as old as the origin of complex life, and as recent as the effects of global warming on marine invertebrates. David got his PhD at UCLA working with Dr. David Jacobs. He then went on to do postdoctoral fellowships at MIT (with Dr. Roger Summons) and Caltech (with Dr. Lea Goentoro) before joining the faculty at UC Davis. In addition to his research, Dr. Gold is also the manager of the UC Davis Fossil Collection and the Faculty Director of the UC Davis CalTeach/MAST Program, which trains STEM undergraduates to become K-12 teachers.   Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

After less than a year from the end of our first season, Belief in the Future is coming back into a world where religion and technology are now crashing into each other. *** Belief is affiliated with the Faith Family Technology Network. It is a production of Sinai and Synapses and is supported by the Templeton World Charity Foundation. This episode was edited by M. Louis Gordon, and our production manager is Misha Holleb. Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode 137 In part 28 of our Sinai and Synapses interview series, we are talking with Andrew Rick-Miller. He is a co-founder and the current Executive Director of Science for the Church, a ministry seeking to help strengthen the church through engagement with science. Previously, he spent more than ten years with the John Templeton Foundation, most recently leading the Religious Engagement Department.    Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

This week we talk about a company called TransAstra that wants to go get an asteroid and put it into orbit around Earth so they can mine it. Music Provided By: Greg Gibbs / Most Guitars Are Made of Trees Miracles of Modern Science / The Singularity

If you're up for a challenge and love a good brain teaser, come check out some Math Riddles That Will Scramble Your Synapses. These puzzles are perfect for testing your problem-solving skills and giving your brain a serious workout. Whether you're a math whiz or just looking for some fun, these riddles are sure to keep you on your toes. Dive in and see how many you can solve! Learn more about your ad choices. Visit megaphone.fm/adchoices

Neurologic emergencies don't wait for the hospital—and neither should neurology education. This episode breaks down a longitudinal EMS curriculum using cases, simulation, and gamification to improve prehospital neurologic assessment. We'll discuss feasibility, knowledge outcomes, and system-level metrics like door-to-needle time and thrombectomy transfers. Does active learning and simulation meaningfully change prehospital neurologic care—or just test scores? And what does “success” really look like for EMS education? Article: Curriculum Innovation: Training the Front Line A Neurologic Emergencies Curriculum Pilot for First Responders https://www.neurology.org/doi/10.1212/NE9.0000000000200286

In today's episode of DMJXpat, we recap the G20 summit in South Africa, talk about the latest developments in neuroscience, and unpack the political shift in Denmarks capital. For the second half, we interviewed climate reporter Kristin Engel about her visit to COP30 in Brazil last week.

In this week's episode of the Xtalks Life Science Podcast, host Ayesha Rashid, Senior Life Science Journalist at Xtalks, spoke with Peter Vanderklish, PhD, chief scientific officer at Spinogenix, a company developing therapeutics aimed at restoring synaptic connections for conditions such as ALS, Alzheimer's disease, schizophrenia and Fragile X syndrome. Dr. Vanderklish's decades of research, from his graduate work at UC Irvine to his roles at The Scripps Research Institute and UC Irvine, have helped shape our understanding of synaptic function, including post-synaptic long-term potentiation (LTP) mechanisms and the role of integrins in stabilizing synaptic structure. His more recent work focuses on dendritic spine abnormalities in Fragile X syndrome and how these changes relate to chronic anxiety and social avoidance behaviors. Dr. Vanderklish is an Associate Professor in Neuroscience at The Scripps Research Institute and a Visiting Professor in Anatomy and Neurobiology at UC Irvine. Tune in to learn how Spinogenix is advancing novel therapies designed to rebuild synapses and transform treatment for neurological diseases. For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/ Follow Us on Social Media Twitter: https://twitter.com/Xtalks Instagram: https://www.instagram.com/xtalks/ Facebook: https://www.facebook.com/Xtalks.Webinars/ LinkedIn: https://www.linkedin.com/company/xtalks-webconferences YouTube: https://www.youtube.com/c/XtalksWebinars/featured

Episode 136 In part 27 of our Sinai and Synapses interview series, we are talking with Rev. Danny Lybarger. Danny is the Lead and Founding Pastor of The Well, a vibrant and inclusive United Methodist Church plant in Weldon Spring, MO, known for its commitment to creating safe spaces for all, especially those traditionally marginalized by the church. With a BA from George Fox University and an M.Div from United Theological Seminary, Danny combines theological depth with a passion for bridging the gap between faith and everyday life. Under his leadership, The Well has experienced significant growth and has been viewed as a compelling new model for ministry at the intersection of inclusivity and evangelicalism. Outside of pastoring, Danny enjoys spending time with his family, staying active at CrossFit St. Louis, and coaching his kids' sports teams.   Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

Episode 135 In part 26 of our Sinai and Synapses interview series, we are talking with Dr. Randy Wedin. He is a freelance science writer and a Lay Teacher at the Minnesota Zen Meditation Center (MZMC). He earned his PhD in Chemistry at Harvard University and his BA in Chemistry and English Literature at St. Olaf College (Minnesota). As a science writer, he uses his communication skills to bridge the gap between the worlds of science, business, government, and the public. He has research and writing experience on a broad range of science-related topics, from green chemistry, drug development, and sustainability to smart grid, public outreach, and K-12 science education. In addition, he has written creative nonfiction essays and op-ed articles for general audiences on subjects related to parenting, relationships, and daily life, often using metaphors from the world of science to provide new perspectives on these topics. His current focus at MZMC is on exploring the relationship of science and Zen Buddhism in his dharma talks and a six-week course he taught on “Zen and Science”.   Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

In this episode, my guest is Dr. Michael Kilgard, PhD, a professor of neuroscience at the University of Texas at Dallas and a leading expert on neuroplasticity and learning across the lifespan. We discuss the need for alertness, effortful focus, post-learning reflection and sleep to induce neuroplasticity, and how dopamine, acetylcholine, serotonin and norepinephrine are each involved. He explains the behavioral steps for neuroplasticity, as well as vagal nerve stimulation (VNS) and other therapies for tinnitus, stroke, depression, PTSD and paralysis. This episode ought to be of use to anyone interested in understanding the modern science of brain rewiring and learning to improve cognitive or motor skills or treat sensory or motor disorders. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Wealthfront*: https://wealthfront.com/huberman Carbon: https://joincarbon.com/huberman Function: https://functionhealth.com/huberman *This experience may not be representative of the experience of other clients of Wealthfront, and there is no guarantee that all clients will have similar experiences. Cash Account is offered by Wealthfront Brokerage LLC, Member FINRA/SIPC. The Annual Percentage Yield (“APY”) on cash deposits as of December 27,‬ 2024, is representative, subject to change, and requires no minimum. Funds in the Cash Account are swept to partner banks where they earn the variable‭ APY. Promo terms and FDIC coverage conditions apply. Same-day withdrawal or instant payment transfers may be limited by destination institutions, daily transaction caps, and by participating entities such as Wells Fargo, the RTP® Network, and FedNow® Service. New Cash Account deposits are subject to a 2-4 day holding period before becoming available for transfer. Timestamps (00:00) Michael Kilgard (03:24) Neuroplasticity (05:13) Child vs Adult Plasticity, Childhood Development & Learning (09:37) Sponsors: Eight Sleep & Wealthfront (12:41) Kids, Real vs Artificial Experiences & Balance, Video Games, Natural World (21:13) Social Media & Videos, Kids, Overstimulation & Development (33:42) Early Language Development, Passive vs Real Experiences, Kids & Adults (39:23) Sponsors: AG1 & Carbon (42:44) Learning & Plasticity Requirements; Focus, Friction, Rest & Reflection (52:24) Brain Connections, Complexity, Life Experiences & Plasticity (1:02:51) Learning, Reflection, Visualization, Testing (1:09:45) Experience Diversity & Time, Happiness, Life Appreciation (1:18:05) Sponsor: Function (1:19:53) Learning & Life Meaning (1:23:25) Neuromodulators, Brain Complexity, Synaptic Eligibility Trace & Learning (1:34:28) Synapses, Therapy for PTSD, Rewiring the Brain (1:39:01) Vagus Nerve Stimulation (VNS), Stroke, Spinal Cord Injury, Tinnitus, PTSD (1:47:33) Psychedelics, Neurostimulation, Importance of Timing (1:57:47) Electroconvulsive Therapy (ECT) & Major Depression (2:01:51) Psychedelics/SSRIs as Plasticity Tools, SSRIs & Bone Strength, Failed Clinical Trials (2:13:18) Can VNS Accelerate Learning? (2:16:01) VNS Surgery, Patient Use & Specificity, Closed-Loop Vagus Nerve Stimulation (2:18:18) Tinnitus Cause, Incidence & Self-Amplification; PTSD & Control (2:28:12) VNS for Tinnitus; Disease Complexity & Treatments, Lazy Eye (2:41:05) Complexity of Disease Treatments & Combination Therapies (2:48:50) Brain-Machine Interfaces, Information & Experiences; Closed-Loop Feedback; Resilience (2:59:09) Evolving Clinical Trials, Combination Treatments & Disease Complexity (3:05:21) Acknowledgements (3:07:04) Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

David Zvi Kalman, a research fellow at the Hartman Institute and Sinai and Synapses, is one of the foremost thinkers looking at the intersection of artificial intelligence and Jewish life. While many in the Jewish community worry about destruction of past traditions, Kalman looks to the future. He looks at what could be the next big transformation in Jewish thought—on the margins today, mainsteam tomorrow. Case in point: artificial intelligence. Kalman posits that AI, unlike previous technological advancements, has the unique ability to mimic human behaviour—a characteristic that could fundamentally alter our relationship with work, productivity and even religious practice. How are rabbis using AI today? Could the machines one day issue halachic rulings? Will it transform the role of rabbis? Kalman joins as guest host of Not in Heaven, The CJN's podcast about the future of Jewish communal life and spiritual practice. Credits Hosts: Avi Finegold, Yedida Eisenstat, Matthew Leibl Production team: Zachary Judah Kauffman (editor), Michael Fraiman (executive producer) Music: Socalled Support The CJN Subscribe to The CJN newsletter Donate to The CJN (+ get a charitable tax receipt) Subscribe to Not in Heaven (Not sure how? Click here)

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Welcome to a new episode of the Future Generations podcast! Today, host Dr. Stanton Hom sits down with Dr. Tom Cowan, a physician, author, and iconoclast in the world of health and wellness. Dr. Cowan shares his radical perspectives on the foundations of biology and medicine, questioning the existence of viruses, hormones, and even the structure of modern education. This episode is a must-listen for parents, educators, health professionals, and anyone ready to challenge conventional wisdom and reclaim agency in raising healthy, autonomous children. Together, Dr. Hom and Dr. Cowan explore how simplicity, critical thinking, and trusting our innate wisdom can transform families and communities.   Highlights: "You don't need to know what's true in order to know what's not true."   "The only thing you teach in school is how to be schooled."   "Life becomes very different when you think, why do you eat a tomato? Because it feels good, not because of vitamin A."   "Government is a superstition. We indoctrinate children to believe in authority."   Timestamps: 00:02 – Introduction to Dr. Tom Cowan and the Episode's Themes 02:18 – Dr. Cowan's Journey: From Reluctant Doctor to Medical Iconoclast 05:47 – The Power of Not Knowing: Questioning Medical Assumptions 10:57 – Rethinking Nutrition: Why We Eat What We Eat 16:39 – Debunking Medical Myths: Nerves, Synapses, and Instant Reactions 22:21 – The Simplicity of Movement and Health 29:29 – Parenting Paradigms: Autonomy, Control, and Learning from Children 43:31 – Schools as Indoctrination: Authority, Government, and Education 46:52 – Mandates, Agency, and Creating New Communities 1:02:22 – Envisioning a New World: Letting Children Lead and Learn Naturally   Resources:   Remember to Rate, Review, and Subscribe on iTunes and Follow us on Spotify!   Learn more about Dr. Stanton Hom on:   Instagram: https://www.instagram.com/drstantonhom  Website: https://futuregenerationssd.com/    Podcast Website: https://thefuturegen.com Twitter: https://twitter.com/drstantonhom  LinkedIn: https://www.linkedin.com/in/stanhomdc  Stay Connected with the Future Generations Podcast:   Instagram:  https://www.instagram.com/futuregenpodcast  Facebook: https://www.facebook.com/futuregenpodcast/  About Dr. Tom Cowan Dr. Thomas Cowan is a well-known alternative medicine doctor, author and speaker, with a common-sense, holistic approach to health and wellness. He has given countless lectures and workshops throughout the U.S. on a variety of subjects in health and medicine and is the author of eight books. Recent publications include Commonsense Childrearing: Unconventional Wisdom for a Nourished Childhood, Breaking the Spell: The Scientific Evidence for Ending the COVID Delusion, The Contagion Myth co-authored by Sally Fallon Morell, Cancer and the New Biology of Water, and Human Heart, Cosmic Heart. Until his recent retirement from active practice, Dr. Cowan had a general-medical practice for 17 years in San Francisco, preceded by 17 years in Peterborough, NH and several years in upstate New York. He was a founding board member of the Weston A. Price Foundation and currently serves as its vice president. Dr. Cowan continues to actively lecture and interview, sharing information via his website, DrTomCowan.com, where he also offers many of the products he has used personally and in his practice. 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Episode 133 In part 25 of our Sinai and Synapses interview series, we are talking with Rabbi Daniel Swartz. He is the spiritual leader at Temple Hesed of Scranton and Executive Director of the Coalition on the Environment and Jewish Life (COEJL). Previously, Rabbi Swartz held leadership positions with Greater Washington Interfaith Power and Light, the National Religious Partnership for the Environment, the Children's Environmental Health Network, and the Religious Action Center of Reform Judaism.  He is the lead author and editor of “To Till and To Tend: A Guide for Jewish Environmental Study and Action” as well as “Faith Communities and Environmental Health."   Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

Episode 131 In part 24 of our Sinai and Synapses interview series, we are talking with Dr Taylor Thomas. She is an interdisciplinary scholar, artist, and educator specializing in philosophy and religion. Currently, she serves as a part-time philosophy instructor and a postdoctoral fellow at the Center for Mind and Culture. Her research focuses on developing interdisciplinary frameworks to address moral agency in today's complex world, aiming to overcome challenges that suppress awareness, freedom, and opportunity. In addition to her academic pursuits, Dr. Thomas engages in creative endeavors, aiming to make existential musings tangible and relatable through multimedia experiences. She is also the host of the "Tillich Today" podcast, which explores the ideas of theologian and philosopher Paul Tillich.   https://taylormariethomas.squarespace.com/ https://podcasts.apple.com/us/podcast/tillich-today/id1725855909 https://www.youtube.com/@BYTE-GEIST   Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

Episode 130 In part 23 of our Sinai and Synapses interview series, we are talking with Dr Fred Ledley. He is a professor of natural & applied science and management at Bentley University in Waltham, MA and director of the center for integration of science and industry. A physician and pediatrician by training, he has performed research in genomics on the faculties of the Baylor College of Medicine, Texas Children's Hospital, and Howard Hughes Medical Institute and founded several biotechnology companies focused on gene therapy or personalized medicine. A widely published researcher, his current work focuses on advancing the translation of scientific discoveries for public value by developing synergies between science, medicine, business, and public policy. He has previously participated in the national, NIH-funded program in “Genetics, Religion and Ethics”, part of the ELSI program of the Human Genome project, and a Templeton-funded program “New Visions in Science, Nature and Religion” at US Santa Barbara. He has written a novel, Sputnik's Child, which explores how science and technology became a faith for members of the baby boom generation and the limits of this faith. He plays clarinet in Shpilkes Klezmer Band and has served on the board of the Boston Jewish Music Festival, Jewish Arts Collaborative, and Celebrity Series of Boston. He joined in a Bnai Mitzvah with his wife, Tamara, at age 31, occasionally reads Torah and serves as darshan as a member of Temple Aliyah in Needham MA, and considers music, hiking the forest, and observing solar eclipses to be spiritual experiences. Check out his book, "Sputnik's Child" here - https://amzn.to/4dgiZAD   Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

This Easter on The Lisa Burke Show, neuroscientist and newly baptised Christian Baroness Susan Greenfield reflects on a life of scientific discovery, spiritual awakening, and the enduring quest to understand consciousness. In this exclusive for The Lisa Burke Show, we welcome one of the most visionary minds of our time—a scientist, entrepreneur, author, and House of Lords peer who has dedicated her life to researching the brain and consciousness, and now journeys inward toward faith. This Easter Sunday, as the season of renewal and rebirth arrives, it is a profound privilege to share with you a conversation that speaks to the mind and the soul, with a science icon of mine. For the first time, newly baptised Baroness Susan Greenfield will mark this Easter as a Christian. Classics to Pharmacology Baroness Susan Greenfield began her intellectual life immersed in Ancient Greek and Latin thanks to an inspirational teacher, and it was there that the seeds of her fierce curiosity took root. For Susan, the Classics developed a rigorously disciplined way of thinking: a mental gymnasium that trained her to ask the deepest questions of what it means to be human. “The Romans and Greeks dealt with love, fate, identity - questions we still grapple with. We've advanced technologically, but philosophically? Not much.” This foundation in classics led her, perhaps surprisingly, into science. Encouraged by a bold Oxford pharmacologist who told her she could “tell us about Homer during the coffee break,” despite not knowing the basics of chemistry, Susan entered neuroscience. Since then, she has gone on to lead research groups at Oxford and founded the biotech company Neuro-Bio Ltd, devoted to early-stage diagnostics and interventions for Alzheimer's disease. Susan is also affiliated with the Oxford Institute of Population Ageing, where she confronts one of our century's greatest challenges: how to extend our health span, alongside lifespan. Alzheimer's, Cognitive Capital & Consciousness The Alzheimer's research Susan leads is revolutionary. She and her team have devoted over 40 years to identifying molecules that could stop neuronal death potentially before symptoms even begin. With a latency window of 10 to 20 years between brain degeneration and visible symptoms, Susan envisions a three-step screening model, starting at home, to catch the disease early enough for real prevention. Yet she is just as passionate about prevention through lifestyle. Cognitive capital may well be the new GDP. A daily life filled with rich conversation, curiosity and mental stimulation is just as vital to our brains as sleep or diet. “The brain should be part of the school curriculum,” Susan insists. “Ten-year-olds can grasp it. It's their brain, their identity. Why should they wait until university?” Susan's take on consciousness brings us to a realm we haven't quite been able to grasp yet in words or measurement. “It's subjective, immeasurable… and that makes it terrifying for many scientists.” She distinguishes between the brain, the mind and consciousness. And then there is the soul. Faith and the Soul “I think the riddle of consciousness is somehow tied up with what we call the soul,” she muses, a space she now embraces more openly. Raised in a home divided between Jewish and Christian grandparents, married to a self-proclaimed atheist, Susan has now found faith in her own way. “I feel a deeper sensitivity to faith now,” she confides. “I believe in God more than I used to.” Her faith journey culminated in a quiet baptism last year. “This Easter,” she says, “feels like my first.” For a neuroscientist whose every instinct is to explore and analyse, this act of surrender is to someone bigger than oneself. It doesn't conflict with her science; it deepens it. “Consciousness may vary in degrees,” she says, “like sleep or anaesthesia. So why not faith?” Female leadership A scientist style icon, Susan has always been unapologetically herself. “I cultivated my look as a kind of armour,” she explains, “but it also reflects who I am—curious, expressive, unwilling to conform.” Now as a CEO, Susan calls on all of us, especially women, to invest, support, and mentor. Indeed, only 2% of venture capital still goes to women. “Leadership,” she says, “is about vision, not control. It's about showing what's possible.” She embodies this truth in every aspect of her life—from the lab to the Lords. Legacy is in addressing the big questions In reflecting on her legacy, Susan doesn't cite awards. She returns, instead, to the passion of discovery. “Just doing the science is the reward,” she says, echoing physicist Richard Feynman. And to young people unsure of their path, she offers the same wisdom that has shaped her own life: don't be afraid to ask the big questions. “It's better to ask some of the questions than to know all the answers.” Happy Easter in whatever way you plan to spend the weekend. To follow more from Susan Greenfield:


A deeply personal and philosophical journey through science, identity and newfound faith. In this exclusive for The Lisa Burke Show, we welcome one of the most visionary minds of our time—a scientist, entrepreneur, author, and House of Lords peer who has dedicated her life to researching the brain and consciousness, and now journeys inward toward faith. This Easter Sunday, as the season of renewal and rebirth arrives, it is a profound privilege to share with you a conversation that speaks to the mind and the soul, with a science icon of mine. For the first time, newly baptised Baroness Susan Greenfield will mark this Easter as a Christian. Classics to Pharmacology Baroness Susan Greenfield began her intellectual life immersed in Ancient Greek and Latin thanks to an inspirational teacher, and it was there that the seeds of her fierce curiosity took root. For Susan, the Classics developed a rigorously disciplined way of thinking: a mental gymnasium that trained her to ask the deepest questions of what it means to be human. “The Romans and Greeks dealt with love, fate, identity - questions we still grapple with. We've advanced technologically, but philosophically? Not much.” This foundation in classics led her, perhaps surprisingly, into science. Encouraged by a bold Oxford pharmacologist who told her she could “tell us about Homer during the coffee break,” despite not knowing the basics of chemistry, Susan entered neuroscience. Since then, she has gone on to lead research groups at Oxford and founded the biotech company Neuro-Bio Ltd, devoted to early-stage diagnostics and interventions for Alzheimer's disease. Susan is also affiliated with the Oxford Institute of Population Ageing, where she confronts one of our century's greatest challenges: how to extend our health span, alongside lifespan. Alzheimer's, Cognitive Capital & Consciousness The Alzheimer's research Susan leads is revolutionary. She and her team have devoted over 40 years to identifying molecules that could stop neuronal death potentially before symptoms even begin. With a latency window of 10 to 20 years between brain degeneration and visible symptoms, Susan envisions a three-step screening model, starting at home, to catch the disease early enough for real prevention. Yet she is just as passionate about prevention through lifestyle. Cognitive capital may well be the new GDP. A daily life filled with rich conversation, curiosity and mental stimulation is just as vital to our brains as sleep or diet. “The brain should be part of the school curriculum,” Susan insists. “Ten-year-olds can grasp it. It's their brain, their identity. Why should they wait until university?” Susan's take on consciousness brings us to a realm we haven't quite been able to grasp yet in words or measurement. “It's subjective, immeasurable… and that makes it terrifying for many scientists.” She distinguishes between the brain, the mind and consciousness. And then there is the soul. Faith and the Soul “I think the riddle of consciousness is somehow tied up with what we call the soul,” she muses, a space she now embraces more openly. Raised in a home divided between Jewish and Christian grandparents, married to a self-proclaimed atheist, Susan has now found faith in her own way. “I feel a deeper sensitivity to faith now,” she confides. “I believe in God more than I used to.” Her faith journey culminated in a quiet baptism last year. “This Easter,” she says, “feels like my first.” For a neuroscientist whose every instinct is to explore and analyse, this act of surrender is to someone bigger than oneself. It doesn't conflict with her science; it deepens it. “Consciousness may vary in degrees,” she says, “like sleep or anaesthesia. So why not faith?” Female leadership A scientist style icon, Susan has always been unapologetically herself. “I cultivated my look as a kind of armour,” she explains, “but it also reflects who I am—curious, expressive, unwilling to conform.” Now as a CEO, Susan calls on all of us, especially women, to invest, support, and mentor. Indeed, only 2% of venture capital still goes to women. “Leadership,” she says, “is about vision, not control. It's about showing what's possible.” She embodies this truth in every aspect of her life—from the lab to the Lords. Legacy is in addressing the big questions In reflecting on her legacy, Susan doesn't cite awards. She returns, instead, to the passion of discovery. “Just doing the science is the reward,” she says, echoing physicist Richard Feynman. And to young people unsure of their path, she offers the same wisdom that has shaped her own life: don't be afraid to ask the big questions. “It's better to ask some of the questions than to know all the answers.” Happy Easter in whatever way you plan to spend the weekend. To follow more from Susan Greenfield:


Episode 128 In part 22 of our Sinai and Synapses interview series, we are talking with Dr Ciara Reyes-Ton. She is a biologist, science writer, and editor who is passionate about science communication to faith communities. She has a Ph.D. in Cell & Molecular Biology from the University of Michigan. She has served as Managing Editor for the American Scientific Affiliation's God & Nature Magazine. She is currently the Digital Content Editor for BioLogos and an Adjunct Professor at Lipscomb University. She also recently helped found the Science Communicators of Faith (SCF), a group dedicated to providing a supportive, collaborative, and Christ-centered community for people of all backgrounds and skill levels to grow in the craft of science communication. She is also the author of “Look Closely,” a science and faith devotional that explores the life of Christ by bringing scripture in conversation with science, from water-walking lizards to dividing cells and resurrecting corals. Outside science, she has a heart for worship and is a proud mom. https://www.mountcarmell.com/   Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

In this episode of Fintech Chatter, Dexter Cousins interviews Julian Fayad, CEO of LoanOptions.ai about the challenges and advantages of bootstrapping a fintech company from the ground up. LoanOptions.ai aims to revolutionise the loan application process. Julian shares insights into how they're using AI to build a mobile first loan application process.Julian first appeared on the show in 2023. We chat about his progress and the lessons he has learned over the past two years. Julian also talks about the transition from a broking business to a technology-focused company, and the launch of Synapses, the API services hub for Fintech! We also discuss the launch of HAILO and LoanOptions.ai, expansion into New Zealand and future plans for market expansion into the US and UAE.Find out more: https://loanoptions.aiChapters00:00 The Bootstrap Journey of a Fintech Founder02:12 Innovating the Loan Application Process10:45 Transitioning from Broking to Technology18:04 Launching New Products and Partnerships25:49 Building an API Services Hub for Fintechs26:48 Navigating B2B Partnerships and SaaS Pricing Strategies32:05 Transitioning from Brokerage to Tech: Lessons Learned35:21 Building a Cohesive Team and Company Culture39:47 Innovative Talent Acquisition Strategies41:45 Valuable Lessons in Business Partnerships46:22 Expanding Horizons: New Markets and Future PlansSend us a textSubscribe Newsletter: https://www.linkedin.com/newsletters/fintech-leaders-7092732051488980992/Connect on Linkedin: https://bit.ly/3DsCJBp

This week, we are joined by Rabbi Geoff Mitelman, founding director of Sinai and Synapses, a non profit that aims to create a vision of religion that embraces critical thinking and scientific inquiry through classes, lectures, seminars, and fellowship opportunities. We discuss the benefits of constructive disagreement, the distinctions between religious, philosophical, and scientific methodologies, and the parameters of contemporary Zionism. You can learn more about Rabbi Mitelman's work at https://sinaiandsynapses.org/ or by following them on Twitter and Instagram. Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode 127 In part 21 of our Sinai and Synapses interview series, we are talking with Rabbi Dr Jack Shlachter.    Jack Shlachter is a physicist who worked at Los Alamos National Laboratory for over thirty years with briefer stints at Brookhaven National Laboratory in New York, the Atomic Energy Agency, and the Comprehensive Test Ban Treaty Organization, the latter two based in Vienna, Austria; he led both the Physics Division and Theoretical Division during his LANL career. In parallel, Jack is an ordained rabbi who led the Jewish congregation in Los Alamos for many years, was the rabbi in Center Moriches, NY, during his years at Brookhaven, and now serves as rabbi of HaMakom, a congregation in Santa Fe, NM as well as the Los Alamos Jewish Center. He has also provided itinerant rabbinic support to far-flung Jewish communities including those in Vienna, Austria,  Beijing, China, and Warsaw, Poland.   Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

Episode 125 This conversation was recorded at the Sinai and Synapses alumni gathering in November 2023. In it, we talk with Dr. Briana Pobiner about the earliest cannibals, fad diets, and what life was like for our paleolithic predecessors.    When you're done with this episode, make sure to check out her other interviews as well!  https://www.downthewormhole.com/e/human-origins-part-1-with-briana-pobiner-big-questions-and-little-bones/ https://www.downthewormhole.com/e/elevating-the-discourse-with-briana-pobiner-paleoanthropologist/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

Episode 125 In part 21 of our Sinai and Synapses interview series, we are talking with JD Stillwater.  He is a science ambassador and author who writes and speaks about profound insights from natural reality, insights that drive paradigm shifts, and cultural awakening. He is an officer of the Religious Naturalist Association, and serves on the governing Council of the Institute on Religion in an Age of Science.   JD Stillwater - https://www.jdstillwater.earth/ Sinai and Synapses - https://sinaiandsynapses.org/   Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

Psychologist Maria Ruberto is back to talk about one of the most important parts of our day: sleep. Starting off with the biology of sleep, Maria takes us through how we get to sleep, what happens when we sleep, and why we desperately need to sleep for good health and longevity. With metaphors galore to make the science as relatable as possible, we discuss the role of melatonin, the impact of screens on our suprachiasmatic nucleus and whether it’s worth cutting your sleep short to exercise? In more practical terms, Maria shares what sleep hygiene actually looks like, and, to Hugh and Josh’s relief, how hormones released during parenthood act to buffer against sleep deprivation. So set your sleep alarms, get comfy, and tuck yourself in for a BIG episode! Sweet dreams x If you would like to watch this full video on YouTub, follow this link: https://bit.ly/4htdJLj If you’d like to subscribe to our Patreon, A Little More Imperfects, sign up here: Patreon.com/theimperfects

Love is a focal point of our favourite movies, music, and most cherished memories. But what really happens in the brain when we fall in love? Is "love at first sight" real? Does the media get it right, or are we being fed myths about what romance really looks like? In this special Valentine's Day episode, we break down the neuroscience of love, attraction, and attachment. From synapses to soulmates, we discuss the neurobiology of falling in love, the role of social media and dating apps, dark sides of love, and the truth behind the "five love languages." We also provide 8 practical tips to improve your own love-life and relationships, based on neuroscience. Whether your a hopeless romanic, skeptical scientist, or just curious about love, we look forward to sharing this knowledge with you. Love, Think Twice. Authors: Elena Koning, Eve Racette Resources: Domestic violence resources (Canada): https://www.canada.ca/en/public-health/services/health-promotion/stop-family-violence/services.html Domestic violence resources (US): https://www.thehotline.org/ Email: thinktwicepodcast@outlook.com Instagram: @thinktwice_podcast LinkedIN: Think Twice Podcast Patreon: https://www.patreon.com/ThinkTwicePodcast Disclaimer: Think Twice is a podcast for general information and entertainment purposes only. The content discussed in the episodes does not reflect the views of the podcast committee members or any institution they are affiliated with. The use of the information presented in this podcast is at the user's own risk and is not intended to replace professional healthcare services.

BUBBLING SYNAPSES, 4min,. France Directed by William Eguienta An idea… needs space, time & love to grow…But, at what cost? Your friends ? Your wife ? Your kids ?Of course not, it needs to be set aside, in a bubble, waiting for the right moment…The wait is long, too long… This must emerge from its bubble, it must come to life, now ! https://www.imdb.com/title/tt31189065 Get to know the filmmaker: What motivated you to make this film? I wanted to test 2d animation for the first time. so i was thinking about a subject that doesn't need speaking characters, but with a strong emotional impact. 48 hours later, the script was written and I was starting working on a storyboard. It's an impulsive creation, no filter, no overthinking, just pure expression of what's in mind What were your initial reactions when watching the audience talking about your film in the feedback video? This kind of film is always strange to evaluate. it's depends a lot on who is the viewer more than an exact message the filmmaker try to spread. I was happy to see that they all catched the poetry behind images and sound to serve the story as an intense experience my film don't hold the viewer by the hand, and everyone seems to understand subtilities in Bubbling Synapses' metaphores, that help me to see and confirm ways to communicate emotions visually, so it's a really important thing to me. Subscribe to the podcast: https://twitter.com/wildsoundpod https://www.instagram.com/wildsoundpod/ https://www.facebook.com/wildsoundpo

For today's episode, we discussing transferring energy from the environment across our biology. We discuss a few quantum theories, atoms, molecules, water, DHA, and NF-kB. Life on Earth is driven by energy from the environment, and this could be missed with humans, and especially with developmental problems like Autism.Water Podcast 1: Rubin, Kruse, Huberman https://www.youtube.com/watch?v=0lBAcUMGIeI&t=43sWater Podcast 2: Gulhane and Kruse (Light changes the Physics of Water !) https://www.youtube.com/watch?v=l9UbguvfpysWater Podcast 3: Gulhane and Kruse https://www.youtube.com/watch?v=W5w0WainlMMhttps://www.plefa.com/article/S0952-3278(12)00147-0/abstracthttps://pmc.ncbi.nlm.nih.gov/articles/PMC5793004/#:~:text=Electrons%20exist%20in%20all%20matter,role%20in%20oxidation%2Dreduction%20reactions.Quantum-coherent energy transfer: implications for biology and new energy technologies https://pmc.ncbi.nlm.nih.gov/articles/PMC3385675/#:~:text=In%20the%20simplest%20picture%2C%20quantum,transport%20at%20the%20molecular%20scale.Quantum cognition: The possibility of processing with nuclear spins in the brain https://www.sciencedirect.com/science/article/abs/pii/S0003491615003243Role of semiconductivity and ion transport in the electrical conduction of melanin https://www.pnas.org/doi/10.1073/pnas.11199481090:00 Intro0:40 Quantum Biology, Coherence, Thermodynamics, Water, DHA, NF-kB, and transferring energy - Atoms & Molecules2:00 Oxygen and CCO; Mitochondria3:55 Quantum Biology; Environments influence Atoms & Molecules5:50 Coherence & States; Light guides Life on Earth; Light provides Energy after it hits Matter7:16 Modern Human Environments7:41 Quantum Thermodynamics; Melanin, Electrons; Rules9:03 Biophotons, Photons and Lux; Seasonal Impact11:15 Electrons & Mitochondria; Real sources of Energy12:00 Artificial Light versus 280nm-3100nm Light; Big Harma & GLP-1 sidebar14:16 Autism and Loss of Biological Energy; changes in Light15:43 Electrons in Biology; Water; Coherent Domains; Semiconductors17:15 DHA; Electron Efficiency; Cells; Photoreceptors and Converting Energy and Developing Nervous Systems (plural)19:20 Phylogeny of Oxytocin and DHA sidebar; pi-electons; DHA dictates DNA22:40 Jack Kruse Quote23:36 Cells, Tissues, & Synapses; Origins of Autism; DHA roles26:14 Autism and X, Y, Z comorbid conditions (plural); definitions of Autism (modern versus origins), Criteria29:23 DHA takeaways; efficiency31:41 NF-kB; creating the womb and nervous systems; Autism and Orbitofrontal Cortex (OFC)35:06 Reviews/Rating & Contact Info

It's All-In August!When life makes your situation seem impossible, you have to have a strategy ready. Here it is.Self-brain surgery tip #4:The more you think about something, the more easily it returns to your mind in the future. Synapses that fire together, wire together. This is why negative thinking is so harmful: it automates negativity in your brain. Change it to something positive!A few thoughts on generational family issues, neuroscience, and the power of Jesus to break chains. Scriptures MentionedIsaiah 55:11Deuteronomy 7:9Numbers 14:18Exodus 34:7Ezekiel 18:20Textooks for All-In August:All In, by Mark Batterson, Hope Is the First Dose by me, and Play the Man by Mark BattersonScripture for the Month: II Corinthians 5:14-17, Luke 9:23-25, Galatians 5:22-23, I Corinthians 2:16 Are you with us? Send a voicemail and let us know who you are, where you live, and that you're All-In!Follow me @drleewarren on Instagram for daily inspiration. Leave a voicemail with your question or comment!Five Ways You Can Support this show:Pray for us!Subscribe, like, and share it with your friends! (We even have a YouTube channel!)Leave reviews and comments wherever you listen to podcasts!You can become a paid partner of the podcast and get special bonus episodes and lots more content by clicking here. Visit one of our affiliate partners and consider using their products (we use them every day):Improve your gut health, support your immune system, and protect your brain with Pique!Other Helpful Links:Click here to access the Hope Is the First Dose playlist of hopeful, healing songs!Be sure to check out my new book, Hope Is the First Dose!Here's a free 5-day Bible study on YouVersion/BibleApp based on my new book!Sign up for my weekly Self-Brain Surgery Newsletter here!All recent episodes with transcripts are available here! (00:00) - All In August (05:59) - Break Those Chains (12:26) - Generational Patterns (15:02) - Power of Positivity

This episode is all about synapses, or conduits of change

If you're up for a challenge and love a good brain teaser, come check out some Math Riddles That Will Scramble Your Synapses. These puzzles are perfect for testing your problem-solving skills and giving your brain a serious workout. Whether you're a math whiz or just looking for some fun, these riddles are sure to keep you on your toes. Dive in and see how many you can solve! #brightside Animation is created by Bright Side. ---------------------------------------------------------------------------------------- Music from TheSoul Sound: https://thesoul-sound.com/ Check our Bright Side podcast on Spotify and leave a positive review! https://open.spotify.com/show/0hUkPxD... Subscribe to Bright Side: https://goo.gl/rQTJZz ---------------------------------------------------------------------------------------- Our Social Media: Facebook:   / brightside   Instagram:   / brightside.official   TikTok: https://www.tiktok.com/@brightside.of... Stock materials (photos, footages and other): https://www.depositphotos.com https://www.shutterstock.com https://www.eastnews.ru ---------------------------------------------------------------------------------------- For more videos and articles visit: http://www.brightside.me Learn more about your ad choices. Visit megaphone.fm/adchoices

-- We're re-releasing our conversation with Carla Shatz, one of our favorites from the archive, which comes up all the time on the show in the context of brain plasticity and aging. Enjoy, and see you next time! -NW -- When we're kids, our brains are amazing at learning. We absorb information from the outside world with ease, and we can adapt to anything. But as we age, our brains become a little more fixed. Our brain circuits become a little less flexible. You may have heard of a concept called neuroplasticity, our brain's ability to change or rewire itself. This is of course central to learning and memory, but it's also important for understanding a surprisingly wide array of medical conditions, including things like epilepsy, depression, even Alzheimer's disease. Today's guest, Carla Shatz, is a pioneer in understanding how our brains are sculpted by our experiences. She's credited with coining the phrase neurons that fire together, wire together. Her work over the past 40 years is foundational to how we understand the brain today. So I was excited to talk to Shatz about our brain's capacity for change, and I started off by asking about this sort of simple question, why exactly do we have this learning superpower as kids to do things like pick up languages and why does it go away?Shatz is Sapp Family Provostial Professor of Biology and of Neurobiology and the Catherine Holman Johnson director of Stanford Bio-X. Learn MoreIn conversation with Carla Shatz (Nature Neuroscience)Carla Shatz, her breakthrough discovery in vision and the developing brain (Stanford Medicine Magazine)Making an Old Brain Young | Carla Shatz (TEDxStanford)Carla Shatz Kavli Prize Laureate LectureStanford scientists discover a protein in nerves that determines which brain connections stay and which go (Wu Tsai Neurosciences Institute)Episode CreditsThis episode was produced by Webby award-winning producer Michael Osborne, with production assistance by Morgan Honaker, and hosted by Nicholas Weiler. Art by Aimee Garza.Send us a text!Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience. Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

In today's episode, we're delving into the intricate relationship between functional nutrition, innovative strategies, and the healing power of nature. I'll be your guide as we explore cutting-edge research on brain health, detoxification, and sleep optimization.   We'll start by unraveling the science behind the glymphatic system—a fascinating network responsible for detoxifying the brain. I'll share insights into how this system functions and why it's crucial for maintaining optimal brain health.    Join me for an enlightening interview with Dr. Sarah Labisco as we discuss practical strategies for activating the glymphatic system and improving sleep quality. From lifestyle adjustments to the therapeutic potential of essential oils, we'll uncover a treasure trove of tips to support your journey towards holistic wellness. So, grab your favorite beverage and let's embark on a journey to unlock the secrets of enhanced brain health, detoxification, and restorative sleep.   In This Episode:    00:00 Unlocking the Secrets of Einstein's Brain: The Power of Synapses   02:51 Deep Dive into the Glymphatic System: Enhancing Brain Detoxification   04:09 Maximizing Brain Health: Strategies for Optimal Glymphatic Function   20:34 The Essential Role of Sleep in Brain Detoxification   21:13 Holistic Approaches to Enhancing Sleep and Brain Health   34:00 The Power of Essential Oils in Supporting the Glymphatic System   36:43 Transformative Health Advice: Ditch, Switch, and Thrive   39:17 Introduction to Dr. Jocker's Functional Nutrition Podcast   41:38 Interview with Dr. Sarah Labisco: Activating the Glymphatic System   41:56 Deep Dive into the Glymphatic System and Brain Health   44:45 The Importance of Sleep and Glymphatic Function   58:10 Optimizing Sleep for Brain Detoxification   01:00:01 Supporting Brain Detoxification and Sleep Optimization       Are swollen legs or ankles slowing you down? Discover the power of Lymph System Support by Pure Health Research. Crafted with natural ingredients like dandelion extract, burdock root, and bromelain, this formula unclogs your lymphatic system, reducing swelling and supporting a healthy inflammatory response.   As a special offer, try Lymph System Support risk-free today and receive a complimentary bottle of curcumin extract. Visit GetLymphHelp.com/jockers to claim yours now. Say hello to renewed vitality and goodbye to discomfort!     Feeling down, irritable, or just not yourself lately? It could be a sign of vitamin D deficiency, and trust me, you're not alone. Even in sunny places like Miami, people are shockingly low on this essential nutrient.   But here's the good news: there's a solution that actually works. Purality Health's Vitamin D3 formula is a game-changer. Unlike most supplements that get destroyed in your stomach, Purality's unique formula ensures maximum absorption, delivering the vitamin directly to your bloodstream where you need it most.   Believe me, I've seen the difference it makes. From mood regulation to immune support and bone health, optimizing your vitamin D levels is crucial for your overall well-being.   And right now, my listeners can get an exclusive 30% off by visiting PuralityHealth.com and using promo code DRJ at checkout. Don't wait any longer to start feeling like your best self again. Take control of your health today with Purality Health's Vitamin D3.     “We've got to get rid of those damaged dysfunctional neuronal cells. Then we've got to build new neuronal connections. That's super key. So not only do we want healthy neurons, but we also want healthy connections between the neurons." - Dr. Jockers   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio   Resources: GetLymphHelp.com/jockers PuralityHealth.com and using promo code DRJ at checkout Website - https://revolutionoilspodcast.com/       Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https://www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/ 

Description:

In this episode, we discuss common genetic and proteins implicated with Autism. This episode is all about preparing for a future episode about Excitation and Inhibition imbalance- a known phenomena with Autism. I play Tug-of-War with Barbed-Wire and talk about a critical factor of our environment implicating proteins and development- This is huge, and necessary. Genomic Architecture of Autism https://www.cell.com/cell/pdf/S0092-8674(22)01324-1.pdfPTEN and mTOR https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01435-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124722014358%3Fshowall%3Dtrue16p11.2, Serotonin, and Possible Social Deficit Rescueshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824539/https://www.nature.com/articles/s41586-018-0416-4https://www.nature.com/articles/s41386-021-01091-6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606557/Dr. Jack Kruse on Autism https://jackkruse.com/category/autism/Cullin 3 / Cul3 https://pubmed.ncbi.nlm.nih.gov/31455858/SHANK3 https://pubmed.ncbi.nlm.nih.gov/?term=shank3Neurexin and Neuroligin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120877/https://www.sciencedirect.com/science/article/pii/S0092867414006734(0:00) Introduction; Excitation and Inhibition; (3:15) Phosphate and Tensin- Pten; Synapses, Soma Size, Migration, Cellular Spine Density, Dendritic Overgrowth, Myelination; mTOR (Rapamycin) and hope; Are cells doing what they should? (10:18) 16p11.2; Serotonin; Raphe and Nucleus Accumbens; Possible Therapeutic Help;(13:40) NEED TO KNOW INFORMATION; Tryptophan, Aromatic Amino Acids, UV-B Light and Proteins; Changes in our Light Environment and Implications to our Biology and Modern Health Concerns; Photoreceptors and Brain and Skin Connection- Neuroectoderm; Circadian Mismatch;(19:24) Back to 16p11.2 and Cortical Development;(22:00) Cullin 3 and Cul3 and Implications to Socialness and Sensory-Gating; Causes of Stereotypic Behaviors; Neuronal Excitability;(24:09) SHANK3; Tissues and Brain; Synaptic Implications; more Spine and Dendritic formation; Sensory Processing; Repetitive Behaviors; Anxiety; Social Deficits; Poor Motor Coordination;(25:59) Neurexin and Neuroligin; Synaptic development and action; Myelination; E/I and Spine; CNTNAP2 and mPFC(29:25) Wrap Up and Contact Informationemail: info.fromthespectrum@gmail.com

John Van Sloten is a Calgary-based writer, teacher, and pastor who is passionate about helping people engage God everywhere. Over the past ten years he has preached dozens of creation and Bible-based sermons on topics like radiation therapy, river hydrology, chemical catalysts, tree branches, human knees, and DNA repair mechanisms. John is a regular columnist with the Calgary Herald and his books include The Day Metallica Came to Church and Every Job a Parable. Over the past ten years, he has been awarded three John Templeton Foundation subgrants for preaching science, has been part of an Ambrose Seminary Science for Seminaries, and has been a Sinai and Synapses fellow. In my time with John, we talk about his latest book, God Speaks Science: What Neurons, Giant Squid, and Supernovae Reveal About Our Creator. John teaches that we can not only learn about God through the Bible, but through creation as well. He shows us that God's love and character can be known more deeply as we marvel at the complexities of His amazing creation. John also shares how his conversion to following God caused him to change his vocation, as well as about the new journey God is leading Him on. John's heart for God and his ability to see him in all things is inspiring. My hope is that this conversation may awaken us all to experience God's presence and work everywhere.Buy Melissa L. Johnson's book, Soul-Deep Beauty: Fighting for Our True Worth in a World Demanding Flawless, here. Learn more about Impossible Beauty and join the community here.

Episode 123 This conversation was recorded at the Sinai and Synapses alumni gathering in November 2023. In it, we talk with Dr. Muhammad Aurangzeb Ahmad about the ethics of AI in Islam, the future of human-computer interaction, and the ethics of bringing a form of consciousness back to life.  Muhammad Aurangzeb Ahmad is a Research Scientist at University of Washington's Harborview Medical Center and an Affiliate Assistant Professor in the Department of Computer Science at University of Washington Bothell. His research focuses on algorithmic nudging at scale, simulation modeling for machine learning, Responsible AI, and personality emulation. He has had academic appointments at University of Washington, Center for Cognitive Science at University of Minnesota, Minnesota Population Center, and the Indian Institute of Technology at Kanpur. Muhammad also has worked in applied AI in industry for several startups and advisor to various governmental bodies. He has a PhD in Computer Science from the University of Minnesota.    Support this podcast on Patreon at https://www.patreon.com/DowntheWormholepodcast   More information at https://www.downthewormhole.com/   produced by Zack Jackson music by Zack Jackson and Barton Willis 

Soundwaves beckoning your earlobes to attenuate. Speakers reverberating at high velocity. Synapses of the mind sparking a million times per second. It is time to open your cranium and let it all pour in…. Thank you for tuning in & be sure to GIVE US A ‘LIKE' ON FaceBook—>  www.facebook.com/AOTARadio You can tune in LIVE everyREAD MORE

Synapses are where the business of the nervous system happens.(Note: this is an archived episode, normally for paid subscribers only but available for everyone for 7 days!)Lately, we've been talking about the basics of self-brain surgery to learn how to think about our thinking, and the ideas behind my new book.But this isn't just some “self-help” or motivational speaker-type thing. Because the vast majority of your life, the decisions you make, the relationships you have, the things you accomplish or strive for come out of how you think: your attitudes, your thought patterns. Everything about how you handle stress, unexpected challenges, and the hard parts of life is determined by your thinking.But the problem is, most of us spend our lives reacting to our thinking, because we never think about our thinking.And the reality is, our baseline thoughts are not very reliable most of the time. Why? That answer is rooted in the science of how our nervous systems are wired. The bad news is that your nervous system has a set of responses to challenges, threats, and stresses, and that set of responses isn't very specific. In other words, you basically feel the same things in your body when a tiger is actually chasing you as you do when you hear a sound in the next room and wonder if someone's breaking into your house- even if it's just the ice maker. Those triggered responses aren't very helpful when they make us reflexively freak out.But the good news is, your brain can be trained to separate the response from the stimulus. But it requires brain surgery.That's why I'm always saying, “You can't change your life until you change your mind.”In other words, if you keep thinking the same thoughts- if you never change how you look at things or the mental framework from which you approach the world- then you're going to keep experiencing the same patterns and outcomes.And the part of the nervous system that connects two nerves, or nerves and muscles or other organs, is called a synapse. In your brain, there are about 100 trillion of them. Trillion with a T. And when those synapses don't work right, you don't work right.Today, we're going to look at two diseases that affect the synapses between your nerves and your muscles. And I want to show you a little of how the nervous system works, so we can see how important it is to make sure we have healthy synapses.If you want to become healthier, feel better, and be happier, you've got to think about your thinking. But sometimes life creates unhealthy connections- sick synapses- that trigger thought patterns and behaviors in us we're not even aware of.You can't change your life until you change your mind. And severing sick synapses- breaking down those bad connections life has created and making better ones- is a key to getting that done.Remember Proverbs 17:27-28 in The Passion Translation (TPT):27 Can you bridle your tongue when your heart is under pressure?That's how you show that you are wise.An understanding heart keeps you cool, calm, and collected,no matter what you're facing.That's one of the secrets to becoming Infinitely Happier, friend.Learning to stay cool, calm, and collected no matter what we're facing. That's useful during a global pandemic, but it's also useful in everyday life. And it doesn't happen by accident. It happens by severing sick synapses. My friend, we're going to learn how, and we're going to start today.Hope is the First Dose: A Treatment Plan for Recovering from Trauma, Tragedy, and Other Massive Things is coming out on July 25, but you can pre-order it now anywhere books are sold. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit drleewarren.substack.com/subscribe

An introduction to hormones and the endocrine system, including a discussion of the definition of hormones and their production, storage, release, and mechanisms of action. I also consider the mechanisms of control and regulation of hormone production, focusing on the role of the hippocampus and the pituitary gland. I conclude with an overview of major endocrine glands in the human body, including the gonads, adrenal glands, thyroid gland, and the thymus. Recommended pre-listening is Episode 38: Neurons and Synapses. If you enjoyed the podcast please consider supporting the show by making a PayPal donation or becoming a Patreon supporter. https://www.patreon.com/jamesfodor https://www.paypal.me/ScienceofEverything

A journey through the complex network of regions controlling the human motor system, beginning with the spinal cord and its central pattern generators, and working up through the primary motor cortex, the premotor cortex, the posterior parietal cortex, the cerebellum, and the basal ganglia. I discuss the computational roles of each part of the motor control hierarchy, focusing on what functions are performed and what information is represented in each unique brain region. Overall I emphasise the complex interaction between top-down and bottom-up feedback in controlling muscle movement and executing complex motor tasks. Recommended pre-listening is Episode 132: The Muscular System, and Episode 38: Neurons and Synapses.   If you enjoyed the podcast please consider supporting the show by making a PayPal donation or becoming a Patreon supporter. https://www.patreon.com/jamesfodor https://www.paypal.me/ScienceofEverything