Podcasts about dvp

Blockchain DXB Podcast – 15th May EpisodeTitle: CPI Drops to 4-Year Low | Trump's $1.2 Trillion Middle East Play | Ethereum's Trillion Dollar Security | Ondo's Cross-Chain DvP | VanEck's NODE ETF

US equities closed missed overnight, with the Dow Jones up 0.28%, the S&P500 up 0.06% and the Nasdaq slightly lower just 0.1%. S&P500 futures are pointing lower this morning, after the index posted five straight winning sessions. Investors are preparing for earnings week, with approximately a third of S&P500- listed firms posting results.  European markets were all higher with the FTSE 100 posting its best winning streak in over 5 years. Yesterday our local market advanced 0.36% with 10 of the 11 industry sectors in the green. Energy and technology advanced the most, while materials was the only sector to close lower. Iluka Resources (ASX:ILU) lead the market rally, while healthcare companies Clarity Pharmaceuticals (ASX:CU6) and Telix Pharmaceuticals (ASX:TLX) declined the most.  What to watch todayThe Australian market is set to open higher this morning, with the SPI futures suggesting a 0.21% rise at the open this morning. In commodities, Crude oil is trading 1.57% lower at around US$62.00 per barrel, as tariff- driven growth concerns threatened to dampen fuel consumption, while supply surged. OPEC+ surprised markets by adding approximately 411,000 barrels per day in May, reversing much of last year's cutbacks. The gold price is up 0.57% at US$3,338.85 an ounce, boosted by bargain hunting and cautious sentiment ahead of key US economic data, as well as US- China trade developments. And iron ore is currently steady at US$99.91 per tonne.  Trading IdeasBell Potter maintains a Buy rating on mining contractor and operator Develop Global (ASX:DVP). Their price target remains unchanged at $4.00 and at DVP's current share price of $2.71 this implies 48% share price growth in a year. And Trading Central have identified a bearish signal in Lendlease Group (ASX:LLC) indicating that the stock price may fall from the close of $5.08 to the range of $4.05 - $4.25 over 18 days, according to the standard principles of technical analysis. 

Denny Hamlin is breaking down his Darlington win and the late-race strategy that helped No. 11 take the No.1 spot -- two weeks in a row. Denny explains how perfect timing and a flawless final pit stop helped him gain track position to beat the odds and seal the deal yet again. He also opens up about his connection with Carl Edwards, gives his take on the DVP policy, and looks ahead to Bristol where there's one question on everyone's mind -- can he make it three straight?  

Cami Wilson, DVP of Training & Development at BeallsInc, discusses here extensive retail career at Kohl's, joining Bealls, advancements within T&D, and future trainings at Bealls.  Interested in a Career at Bealls? – https://www.beallsinc.com/beallsinc/careers Follow Matt Beall on LinkedIn - https://www.linkedin.com/in/matt-beall-legacy/ Episode Timeline:00:00 Introductions04:13 Background08:33 Bealls Disaster Relief12:06 Joining Bealls21:01 First Impressions?23:06 Becoming One Bealls29:28 Bealls Values42:44 What's Next?58:12 Closing

Der erste Wahlgang für die Nachfolge von Friedrich Ebert als Reichspräsident war geschlagen. Auf die drei Kandidaten der sogenannten Weimarer Koalition – den Sozialdemokraten Otto Braun, Wilhelm Marx vom Zentrum sowie Willy Hellpach von der DDP – entfielen zusammen zwar annähernd 50 Prozent der Stimmen. Durch die Zersplitterung der Kandidaturen lag jedoch ein anderer Bewerber an der Spitze des Feldes: Kurt Jarres, den DVP, DNVP und noch einige andere Parteien aus dem rechten Spektrum ins Rennen geschickt hatten, konnte mit 38,8 Prozent fast zehn Punkte mehr als der zweitplatzierte Braun auf sich vereinen und auf einen Sieg auch im zweiten Wahlgang vier Wochen später, bei dem die einfache Mehrheit genügte, hoffen. Mit ihm tat dies auch die konservative Bergedorfer Zeitung, die nicht nur die reichsweiten Zahlen mit denen der letzten Reichstagswahlen verglich, sondern auch das kommunale Ergebnis kannte. Es liest Rosa Leu.

The ASX 200 dropped 30 points to 7969 (0.4%) as the banks came under a little pressure on car tariffs in the US. The Big Bank Basket rose to $245.27 (+0.1%).  Financial services also under some pressure as the OPT fall out continues. MQG down 1.1% and GQG off 1.8%. PNI also falling 3.5%. REITs also under some pressure with GMG falling 4.0% as data centre growth seems to be questioned. SCG off 1.4% and GPT down 2.0%. Tech is also under pressure with WTC off 2.0% as AussieSuper sells out on government issues. The All -Tech Index down 2.6%. REA and CAR fell too with DHG down 4.9% on CoStar revised bid being best and final. Retail down too with car stocks sliding, APE off 2.7%, BAP down 2.5% and ARB down 2.0%. Resources were holding their end up, gold miners pushing ahead again, NEM up 0.7% and NST up 0.8%. GOR rose 3.9% as shareholders urged the board to engage. LTR up 1.5% and MIN slightly firmer. BHP, RIO and FMG seeing small gains. JHX finding some support up 2.1% with uranium shorts back in control. BOE falling 5.0% and NXG off 0.3%. Oil and gas better WDS up 1.5%. In corporate news, TRS soared 109.5% on a huge premium bid from Dollarama. RPL fell another 8.9% as OPT fall out continues. DVP quashed rumours on BGL contract. Nothing significant on the economic front although it looks like Albanese will call an election tomorrow for May 3rd. Asian markets were weaker with car makers under pressure. Japan down 0.9%, HK up 1% and China up 0.4%. 10-year yields 4.50%Want to invest with Marcus Today? The Managed Strategy Portfolio is designed for investors seeking exposure to our strategy while we do the hard work for you. If you're looking for personal financial advice, our friends at Clime Investment Management can help. Their team of licensed advisers operates across most states, offering tailored financial planning services.  Why not sign up for a free trial? Gain access to expert insights, research, and analysis to become a better investor.

“Eventually, my dream would be to simulate a virtual cell.”—Demis HassabisThe aspiration to build the virtual cell is considered to be equivalent to a moonshot for digital biology. Recently, 42 leading life scientists published a paper in Cell on why this is so vital, and how it may ultimately be accomplished. This conversation is with 2 of the authors, Charlotte Bunne, now at EPFL and Steve Quake, a Professor at Stanford University, who heads up science at the Chan-Zuckerberg Initiative The audio (above) is available on iTunes and Spotify. The full video is linked here, at the top, and also can be found on YouTube.TRANSCRIPT WITH LINKS TO AUDIO Eric Topol (00:06):Hello, it's Eric Topol with Ground Truths and we've got a really hot topic today, the virtual cell. And what I think is extraordinarily important futuristic paper that recently appeared in the journal Cell and the first author, Charlotte Bunne from EPFL, previously at Stanford's Computer Science. And Steve Quake, a young friend of mine for many years who heads up the Chan Zuckerberg Initiative (CZI) as well as a professor at Stanford. So welcome, Charlotte and Steve.Steve Quake (00:42):Thanks, Eric. It's great to be here.Charlotte Bunne:Thanks for having me.Eric Topol (00:45):Yeah. So you wrote this article that Charlotte, the first author, and Steve, one of the senior authors, appeared in Cell in December and it just grabbed me, “How to build the virtual cell with artificial intelligence: Priorities and opportunities.” It's the holy grail of biology. We're in this era of digital biology and as you point out in the paper, it's a convergence of what's happening in AI, which is just moving at a velocity that's just so extraordinary and what's happening in biology. So maybe we can start off by, you had some 42 authors that I assume they congregated for a conference or something or how did you get 42 people to agree to the words in this paper?Steve Quake (01:33):We did. We had a meeting at CZI to bring community members together from many different parts of the community, from computer science to bioinformatics, AI experts, biologists who don't trust any of this. We wanted to have some real contrarians in the mix as well and have them have a conversation together about is there an opportunity here? What's the shape of it? What's realistic to expect? And that was sort of the genesis of the article.Eric Topol (02:02):And Charlotte, how did you get to be drafting the paper?Charlotte Bunne (02:09):So I did my postdoc with Aviv Regev at Genentech and Jure Leskovec at CZI and Jure was part of the residency program of CZI. And so, this is how we got involved and you had also prior work with Steve on the universal cell embedding. So this is how everything got started.Eric Topol (02:29):And it's actually amazing because it's a who's who of people who work in life science, AI and digital biology and omics. I mean it's pretty darn impressive. So I thought I'd start off with a quote in the article because it kind of tells a story of where this could go. So the quote was in the paper, “AIVC (artificial intelligence virtual cell) has the potential to revolutionize the scientific process, leading to future breakthroughs in biomedical research, personalized medicine, drug discovery, cell engineering, and programmable biology.” That's a pretty big statement. So maybe we can just kind of toss that around a bit and maybe give it a little more thoughts and color as to what you were positing there.Steve Quake (03:19):Yeah, Charlotte, you want me to take the first shot at that? Okay. So Eric, it is a bold claim and we have a really bold ambition here. We view that over the course of a decade, AI is going to provide the ability to make a transformative computational tool for biology. Right now, cell biology is 90% experimental and 10% computational, roughly speaking. And you've got to do just all kinds of tedious, expensive, challenging lab work to get to the answer. And I don't think AI is going to replace that, but it can invert the ratio. So within 10 years I think we can get to biology being 90% computational and 10% experimental. And the goal of the virtual cell is to build a tool that'll do that.Eric Topol (04:09):And I think a lot of people may not understand why it is considered the holy grail because it is the fundamental unit of life and it's incredibly complex. It's not just all the things happening in the cell with atoms and molecules and organelles and everything inside, but then there's also the interactions the cell to other cells in the outside tissue and world. So I mean it's really quite extraordinary challenge that you've taken on here. And I guess there's some debate, do we have the right foundation? We're going to get into foundation models in a second. A good friend of mine and part of this whole I think process that you got together, Eran Segal from Israel, he said, “We're at this tipping point…All the stars are aligned, and we have all the different components: the data, the compute, the modeling.” And in the paper you describe how we have over the last couple of decades have so many different data sets that are rich that are global initiatives. But then there's also questions. Do we really have the data? I think Bo Wang especially asked about that. Maybe Charlotte, what are your thoughts about data deficiency? There's a lot of data, but do you really have what we need before we bring them all together for this kind of single model that will get us some to the virtual cell?Charlotte Bunne (05:41):So I think, I mean one core idea of building this AIVC is that we basically can leverage all experimental data that is overall collected. So this also goes back to the point Steve just made. So meaning that we basically can integrate across many different studies data because we have AI algorithms or the architectures that power such an AIVC are able to integrate basically data sets on many different scales. So we are going a bit away from this dogma. I'm designing one algorithm from one dataset to this idea of I have an architecture that can take in multiple dataset on multiple scales. So this will help us a bit in being somewhat efficient with the type of experiments that we need to make and the type of experiments we need to conduct. And again, what Steve just said, ultimately, we can very much steer which data sets we need to collect.Charlotte Bunne (06:34):Currently, of course we don't have all the data that is sufficient. I mean in particular, I think most of the tissues we have, they are healthy tissues. We don't have all the disease phenotypes that we would like to measure, having patient data is always a very tricky case. We have mostly non-interventional data, meaning we have very limited understanding of somehow the effect of different perturbations. Perturbations that happen on many different scales in many different environments. So we need to collect a lot here. I think the overall journey that we are going with is that we take the data that we have, we make clever decisions on the data that we will collect in the future, and we have this also self-improving entity that is aware of what it doesn't know. So we need to be able to understand how well can I predict something on this somewhat regime. If I cannot, then we should focus our data collection effort into this. So I think that's not a present state, but this will basically also guide the future collection.Eric Topol (07:41):Speaking of data, one of the things I think that's fascinating is we saw how AlphaFold2 really revolutionized predicting proteins. But remember that was based on this extraordinary resource that had been built, the Protein Data Bank that enabled that. And for the virtual cell there's no such thing as a protein data bank. It's so much more as you emphasize Charlotte, it's so much dynamic and these perturbations that are just all across the board as you emphasize. Now the human cell atlas, which currently some tens of millions, but going into a billion cells, we learned that it used to be 200 cell types. Now I guess it's well over 5,000 and that we have 37 trillion cells approximately in the average person adult's body is a formidable map that's being made now. And I guess the idea that you're advancing is that we used to, and this goes back to a statement you made earlier, Steve, everything we did in science was hypothesis driven. But if we could get computational model of the virtual cell, then we can have AI exploration of the whole field. Is that really the nuts of this?Steve Quake (09:06):Yes. A couple thoughts on that, maybe Theo Karaletsos, our lead AI person at CZI says machine learning is the formalism through which we understand high dimensional data and I think that's a very deep statement. And biological systems are intrinsically very high dimensional. You've got 20,000 genes in the human genome in these cell atlases. You're measuring all of them at the same time in each single cell. And there's a lot of structure in the relationships of their gene expression there that is just not evident to the human eye. And for example, CELL by GENE, our database that collects all the aggregates, all of the single cell transcriptomic data is now over a hundred million cells. And as you mentioned, we're seeing ways to increase that by an order of magnitude in the near future. The project that Jure Leskovec and I worked on together that Charlotte referenced earlier was like a first attempt to build a foundational model on that data to discover some of the correlations and structure that was there.Steve Quake (10:14):And so, with a subset, I think it was the 20 or 30 million cells, we built a large language model and began asking it, what do you understand about the structure of this data? And it kind of discovered lineage relationships without us teaching it. We trained on a matrix of numbers, no biological information there, and it learned a lot about the relationships between cell type and lineage. And that emerged from that high dimensional structure, which was super pleasing to us and really, I mean for me personally gave me the confidence to say this stuff is going to work out. There is a future for the virtual cell. It's not some made up thing. There is real substance there and this is worth investing an enormous amount of CZIs resources in going forward and trying to rally the community around as a project.Eric Topol (11:04):Well yeah, the premise here is that there is a language of life, and you just made a good case that there is if you can predict, if you can query, if you can generate like that. It is reminiscent of the famous Go game of Lee Sedol, that world champion and how the machine came up with a move (Move 37) many, many years ago that no human would've anticipated and I think that's what you're getting at. And the ability for inference and reason now to add to this. So Charlotte, one of the things of course is about, well there's two terms in here that are unfamiliar to many of the listeners or viewers of this podcast, universal representations (UR) and virtual instrument (VIs) that you make a pretty significant part of how you are going about this virtual cell model. So could you describe that and also the embeddings as part of the universal representation (UR) because I think embeddings, or these meaningful relationships are key to what Steve was just talking about.Charlotte Bunne (12:25):Yes. So in order to somewhat leverage very different modalities in order to leverage basically modalities that will take measurements across different scales, like the idea is that we have large, may it be transformer models that might be very different. If I have imaging data, I have a vision transformer, if I have a text data, I have large language models that are designed of course for DNA then they have a very wide context and so on and so forth. But the idea is somewhat that we have models that are connected through the scales of biology because those scales we know. We know which components are somewhat involved or in measurements that are happening upstream. So we have the somewhat interconnection or very large model that will be trained on many different data and we have this internal model representation that somewhat capture everything they've seen. And so, this is what we call those universal representation (UR) that will exist across the scales of biology.Charlotte Bunne (13:22):And what is great about AI, and so I think this is a bit like a history of AI in short is the ability to predict the last years, the ability to generate, we can generate new hypothesis, we can generate modalities that we are missing. We can potentially generate certain cellular state, molecular state have a certain property, but I think what's really coming is this ability to reason. So we see this in those very large language models, the ability to reason about a hypothesis, how we can test it. So this is what those instruments ultimately need to do. So we need to be able to simulate the change of a perturbation on a cellular phenotype. So on the internal representation, the universal representation of a cell state, we need to simulate the fact the mutation has downstream and how this would propagate in our representations upstream. And we need to build many different type of virtual instruments that allow us to basically design and build all those capabilities that ultimately the AI virtual cell needs to possess that will then allow us to reason, to generate hypothesis, to basically predict the next experiment to conduct to predict the outcome of a perturbation experiment to in silico design, cellular states, molecular states, things like that. And this is why we make the separation between internal representation as well as those instruments that operate on those representations.Eric Topol (14:47):Yeah, that's what I really liked is that you basically described the architecture, how you're going to do this. By putting these URs into the VIs, having a decoder and a manipulator and you basically got the idea if you can bring all these different integrations about which of course is pending. Now there are obviously many naysayers here that this is impossible. One of them is this guy, Philip Ball. I don't know if you read the language, How Life Works. Now he's a science journalist and he's a prolific writer. He says, “Comparing life to a machine, a robot, a computer, sells it short. Life is a cascade of processes, each with a distinct integrity and autonomy, the logic of which has no parallel outside the living world.” Is he right? There's no way to model this. It's silly, it's too complex.Steve Quake (15:50):We don't know, alright. And it's great that there's naysayers. If everyone agreed this was doable, would it be worth doing? I mean the whole point is to take risks and get out and do something really challenging in the frontier where you don't know the answer. If we knew that it was doable, I wouldn't be interested in doing it. So I personally am happy that there's not a consensus.Eric Topol (16:16):Well, I mean to capture people's imagination here, if you're successful and you marshal a global effort, I don't know who's going to pay for it because it's a lot of work coming here going forward. But if you can do it, the question here is right today we talk about, oh let's make an organoid so we can figure out how to treat this person's cancer or understand this person's rare disease or whatever. And instead of having to wait weeks for this culture and all the expense and whatnot, you could just do it in a computer and in silico and you have this virtual twin of a person's cells and their tissue and whatnot. So the opportunity here is, I don't know if people get, this is just extraordinary and quick and cheap if you can get there. And it's such a bold initiative idea, who will pay for this do you think?Steve Quake (17:08):Well, CZI is putting an enormous amount of resources into it and it's a major project for us. We have been laying the groundwork for it. We recently put together what I think is if not the largest, one of the largest GPU supercomputer clusters for nonprofit basic science research that came online at the end of last year. And in fact in December we put out an RFA for the scientific community to propose using it to build models. And so we're sharing that resource within the scientific community as I think you appreciate, one of the real challenges in the field has been access to compute resources and industry has it academia at a much lower level. We are able to be somewhere in between, not quite at the level of a private company but the tech company but at a level beyond what most universities are being able to do and we're trying to use that to drive the field forward. We're also planning on launching RFAs we this year to help drive this project forward and funding people globally on that. And we are building a substantial internal effort within CZI to help drive this project forward.Eric Topol (18:17):I think it has the looks of the human genome project, which at time as you know when it was originally launched that people thought, oh, this is impossible. And then look what happened. It got done. And now the sequence of genome is just a commodity, very relatively, very inexpensive compared to what it used to be.Steve Quake (18:36):I think a lot about those parallels. And I will say one thing, Philip Ball, I will concede him the point, the cells are very complicated. The genome project, I mean the sort of genius there was to turn it from a biology problem to a chemistry problem, there is a test tube with a chemical and it work out the structure of that chemical. And if you can do that, the problem is solved. I think what it means to have the virtual cell is much more complex and ambiguous in terms of defining what it's going to do and when you're done. And so, we have our work cut out for us there to try to do that. And that's why a little bit, I established our North Star and CZI for the next decade as understanding the mysteries of the cell and that word mystery is very important to me. I think the molecules, as you pointed out earlier are understood, genome sequenced, protein structure solved or predicted, we know a lot about the molecules. Those are if not solved problems, pretty close to being solved. And the real mystery is how do they work together to create life in the cell? And that's what we're trying to answer with this virtual cell project.Eric Topol (19:43):Yeah, I think another thing that of course is happening concurrently to add the likelihood that you'll be successful is we've never seen the foundation models coming out in life science as they have in recent weeks and months. Never. I mean, I have a paper in Science tomorrow coming out summarizing the progress about not just RNA, DNA, ligands. I mean the whole idea, AlphaFold3, but now Boltz and so many others. It's just amazing how fast the torrent of new foundation models. So Charlotte, what do you think accounts for this? This is unprecedented in life science to see foundation models coming out at this clip on evolution on, I mean you name it, design of every different molecule of life or of course in cells included in that. What do you think is going on here?Charlotte Bunne (20:47):So on the one hand, of course we benefit profits and inherit from all the tremendous efforts that have been made in the last decades on assembling those data sets that are very, very standardized. CELLxGENE is very somehow AI friendly, as you can say, it is somewhat a platform that is easy to feed into algorithms, but at the same time we actually also see really new building mechanisms, design principles of AI algorithms in itself. So I think we have understood that in order to really make progress, build those systems that work well, we need to build AI tools that are designed for biological data. So to give you an easy example, if I use a large language model on text, it's not going to work out of the box for DNA because we have different reading directions, different context lens and many, many, many, many more.Charlotte Bunne (21:40):And if I look at standard computer vision where we can say AI really excels and I'm applying standard computer vision, vision transformers on multiplex images, they're not going to work because normal computer vision architectures, they always expect the same three inputs, RGB, right? In multiplex images, I'm measuring up to 150 proteins potentially in a single experiment, but every study will measure different proteins. So I deal with many different scales like larger scales and I used to attention mechanisms that we have in usual computer vision. Transformers are not going to work anymore, they're not going to scale. And at the same time, I need to be completely flexible in whatever input combination of channel I'm just going to face in this experiment. So this is what we right now did for example, in our very first work, inheriting the design principle that we laid out in the paper AI virtual cell and then come up with new AI architectures that are dealing with these very special requirements that biological data have.Charlotte Bunne (22:46):So we have now a lot of computer scientists that work very, very closely have a very good understanding of biologists. Biologists that are getting much and much more into the computer science. So people who are fluent in both languages somewhat, that are able to now build models that are adopted and designed for biological data. And we don't just take basically computer vision architectures that work well on street scenes and try to apply them on biological data. So it's just a very different way of thinking about it, starting constructing basically specialized architectures, besides of course the tremendous data efforts that have happened in the past.Eric Topol (23:24):Yeah, and we're not even talking about just sequence because we've also got imaging which has gone through a revolution, be able to image subcellular without having to use any types of stains that would disrupt cells. That's another part of the deep learning era that came along. One thing I thought was fascinating in the paper in Cell you wrote, “For instance, the Short Read Archive of biological sequence data holds over 14 petabytes of information, which is 1,000 times larger than the dataset used to train ChatGPT.” I mean that's a lot of tokens, that's a lot of stuff, compute resources. It's almost like you're going to need a DeepSeek type of way to get this. I mean not that DeepSeek as its claim to be so much more economical, but there's a data challenge here in terms of working with that massive amount that is different than the human language. That is our language, wouldn't you say?Steve Quake (24:35):So Eric, that brings to mind one of my favorite quotes from Sydney Brenner who is such a wit. And in 2000 at the sort of early first flush of success in genomics, he said, biology is drowning in a sea of data and starving for knowledge. A very deep statement, right? And that's a little bit what the motivation was for putting the Short Read Archive statistic into the paper there. And again, for me, part of the value of this endeavor of creating a virtual cell is it's a tool to help us translate data into knowledge.Eric Topol (25:14):Yeah, well there's two, I think phenomenal figures in your Cell paper. The first one that kicks across the capabilities of the virtual cell and the second that compares the virtual cell to the real or the physical cell. And we'll link that with this in the transcript. And the other thing we'll link is there's a nice Atlantic article, “A Virtual Cell Is a ‘Holy Grail' of Science. It's Getting Closer.” That might not be quite close as next week or year, but it's getting close and that's good for people who are not well grounded in this because it's much more taken out of the technical realm. This is really exciting. I mean what you're onto here and what's interesting, Steve, since I've known you for so many years earlier in your career you really worked on omics that is being DNA and RNA and in recent times you've made this switch to cells. Is that just because you're trying to anticipate the field or tell us a little bit about your migration.Steve Quake (26:23):Yeah, so a big part of my career has been trying to develop new measurement technologies that'll provide insight into biology. And decades ago that was understanding molecules. Now it's understanding more complex biological things like cells and it was like a natural progression. I mean we built the sequencers, sequenced the genomes, done. And it was clear that people were just going to do that at scale then and create lots of data. Hopefully knowledge would get out of that. But for me as an academic, I never thought I'd be in the position I'm in now was put it that way. I just wanted to keep running a small research group. So I realized I would have to get out of the genome thing and find the next frontier and it became this intersection of microfluidics and genomics, which as you know, I spent a lot of time developing microfluidic tools to analyze cells and try to do single cell biology to understand their heterogeneity. And that through a winding path led me to all these cell atlases and to where we are now.Eric Topol (27:26):Well, we're fortunate for that and also with your work with CZI to help propel that forward and I think it sounds like we're going to need a lot of help to get this thing done. Now Charlotte, as a computer scientist now at EPFL, what are you going to do to keep working on this and what's your career advice for people in computer science who have an interest in digital biology?Charlotte Bunne (27:51):So I work in particular on the prospect of using this to build diagnostic tools and to make diagnostics in the clinic easier because ultimately we have somewhat limited capabilities in the hospital to run deep omics, but the idea of being able to somewhat map with a cheaper and lighter modality or somewhat diagnostic test into something much richer because a model has been seeing all those different data and can basically contextualize it. It's very interesting. We've seen all those pathology foundation models. If I can always run an H&E, but then decide when to run deeper diagnostics to have a better or more accurate prediction, that is very powerful and it's ultimately reducing the costs, but the precision that we have in hospitals. So my faculty position right now is co-located between the School of Life Sciences, School of Computer Science. So I have a dual affiliation and I'm affiliated to the hospitals to actually make this possible and as a career advice, I think don't be shy and stick to your discipline.Charlotte Bunne (28:56):I have a bachelor's in biology, but I never only did biology. I have a PhD in computer science, which you would think a bachelor in biology not necessarily qualifies you through. So I think this interdisciplinarity also requires you to be very fluent, very comfortable in reading many different styles of papers and publications because a publication in a computer science venue will be very, very different from the way we write in biology. So don't stick to your study program, but just be free in selecting whatever course gets you closer to the knowledge you need in order to do the research or whatever task you are building and working on.Eric Topol (29:39):Well, Charlotte, the way you're set up there with this coalescence of life science and computer science is so ideal and so unusual here in the US, so that's fantastic. That's what we need and that's really the underpinning of how you're going to get to the virtual cells, getting these two communities together. And Steve, likewise, you were an engineer and somehow you became one of the pioneers of digital biology way back before it had that term, this interdisciplinary, transdisciplinary. We need so much of that in order for you all to be successful, right?Steve Quake (30:20):Absolutely. I mean there's so much great discovery to be done on the boundary between fields. I trained as a physicist and kind of made my career this boundary between physics and biology and technology development and it's just sort of been a gift that keeps on giving. You've got a new way to measure something, you discover something new scientifically and it just all suggests new things to measure. It's very self-reinforcing.Eric Topol (30:50):Now, a couple of people who you know well have made some pretty big statements about this whole era of digital biology and I think the virtual cell is perhaps the biggest initiative of all the digital biology ongoing efforts, but Jensen Huang wrote, “for the first time in human history, biology has the opportunity to be engineering, not science.” And Demis Hassabis wrote or said, ‘we're seeing engineering science, you have to build the artifact of interest first, and then once you have it, you can use the scientific method to reduce it down and understand its components.' Well here there's a lot to do to understand its components and if we can do that, for example, right now as both of AI drug discoveries and high gear and there's umpteen numbers of companies working on it, but it doesn't account for the cell. I mean it basically is protein, protein ligand interactions. What if we had drug discovery that was cell based? Could you comment about that? Because that doesn't even exist right now.Steve Quake (32:02):Yeah, I mean I can say something first, Charlotte, if you've got thoughts, I'm curious to hear them. So I do think AI approaches are going to be very useful designing molecules. And so, from the perspective of designing new therapeutics, whether they're small molecules or antibodies, yeah, I mean there's a ton of investment in that area that is a near term fruit, perfect thing for venture people to invest in and there's opportunity there. There's been enough proof of principle. However, I do agree with you that if you want to really understand what happens when you drug a target, you're going to want to have some model of the cell and maybe not just the cell, but all the different cell types of the body to understand where toxicity will come from if you have on-target toxicity and whether you get efficacy on the thing you're trying to do.Steve Quake (32:55):And so, we really hope that people will use the virtual cell models we're going to build as part of the drug discovery development process, I agree with you in a little of a blind spot and we think if we make something useful, people will be using it. The other thing I'll say on that point is I'm very enthusiastic about the future of cellular therapies and one of our big bets at CZI has been starting the New York Biohub, which is aimed at really being very ambitious about establishing the engineering and scientific foundations of how to engineer completely, radically more powerful cellular therapies. And the virtual cell is going to help them do that, right? It's going to be essential for them to achieve that mission.Eric Topol (33:39):I think you're pointing out one of the most important things going on in medicine today is how we didn't anticipate that live cell therapy, engineered cells and ideally off the shelf or in vivo, not just having to take them out and work on them outside the body, is a revolution ongoing, and it's not just in cancer, it's in autoimmune diseases and many others. So it's part of the virtual cell need. We need this. One of the things that's a misnomer, I want you both to comment on, we keep talking about single cell, single cell. And there's a paper spatial multi-omics this week, five different single cell scales all integrated. It's great, but we don't get to single cell. We're basically looking at 50 cells, 100 cells. We're not doing single cell because we're not going deep enough. Is that just a matter of time when we actually are doing, and of course the more we do get down to the single or a few cells, the more insights we're going to get. Would you comment about that? Because we have all this literature on single cell comes out every day, but we're not really there yet.Steve Quake (34:53):Charlotte, do you want to take a first pass at that and then I can say something?Charlotte Bunne (34:56):Yes. So it depends. So I think if we look at certain spatial proteomics, we still have subcellular resolutions. So of course, we always measure many different cells, but we are able to somewhat get down to resolution where we can look at certain colocalization of proteins. This also goes back to the point just made before having this very good environment to study drugs. If I want to build a new drug, if I want to build a new protein, the idea of building this multiscale model allows us to actually simulate different, somehow binding changes and binding because we simulate the effect of a drug. Ultimately, the redouts we have they are subcellular. So of course, we often in the spatial biology, we often have a bit like methods that are rather coarse they have a spot that averages over certain some cells like hundreds of cells or few cells.Charlotte Bunne (35:50):But I think we also have more and more technologies that are zooming in that are subcellular where we can actually tag or have those probe-based methods that allow us to zoom in. There's microscopy of individual cells to really capture them in 3D. They are of course not very high throughput yet, but it gives us also an idea of the morphology and how ultimately morphology determine certain somehow cellular properties or cellular phenotype. So I think there's lots of progress also on the experimental and that ultimately will back feed into the AI virtual cell, those models that will be fed by those data. Similarly, looking at dynamics, right, looking at live imaging of individual cells of their morphological changes. Also, this ultimately is data that we'll need to get a better understanding of disease mechanisms, cellular phenotypes functions, perturbation responses.Eric Topol (36:47):Right. Yes, Steve, you can comment on that and the amazing progress that we have made with space and time, spatial temporal resolution, spatial omics over these years, but that we still could go deeper in terms of getting to individual cells, right?Steve Quake (37:06):So, what can we do with a single cell? I'd say we are very mature in our ability to amplify and sequence the genome of a single cell, amplify and sequence the transcriptome of a single cell. You can ask is one cell enough to make a biological conclusion? And maybe I think what you're referring to is people want to see replicates and so you can ask how many cells do you need to see to have confidence in any given biological conclusion, which is a reasonable thing. It's a statistical question in good science. I think I've been very impressed with how the mass spec people have been doing recently. I think they've finally cracked the ability to look at proteins from single cells and they can look at a couple thousand proteins. That was I think one of these Nature method of the year things at the end of last year and deep visual proteomics.Eric Topol (37:59):Deep visual proteomics, yes.Steve Quake (38:00):Yeah, they are over the hump. Yeah, they are over the hump with single cell measurements. Part of what's missing right now I think is the ability to reliably do all of that on the same cell. So this is what Charlotte was referring to be able to do sort of multi-modal measurements on single cells. That's kind of in its infancy and there's a few examples, but there's a lot more work to be done on that. And I think also the fact that these measurements are all destructive right now, and so you're losing the ability to look how the cells evolve over time. You've got to say this time point, I'm going to dissect this thing and look at a state and I don't get to see what happens further down the road. So that's another future I think measurement challenge to be addressed.Eric Topol (38:42):And I think I'm just trying to identify some of the multitude of challenges in this extraordinarily bold initiative because there are no shortage and that's good about it. It is given people lots of work to do to overcome, override some of these challenges. Now before we wrap up, besides the fact that you point out that all the work has to be done and be validated in real experiments, not just live in a virtual AI world, but you also comment about the safety and ethics of this work and assuming you're going to gradually get there and be successful. So could either or both of you comment about that because it's very thoughtful that you're thinking already about that.Steve Quake (41:10):As scientists and members of the larger community, we want to be careful and ensure that we're interacting with people who said policy in a way that ensures that these tools are being used to advance the cause of science and not do things that are detrimental to human health and are used in a way that respects patient privacy. And so, the ethics around how you use all this with respect to individuals is going to be important to be thoughtful about from the beginning. And I also think there's an ethical question around what it means to be publishing papers and you don't want people to be forging papers using data from the virtual cell without being clear about where that came from and pretending that it was a real experiment. So there's issues around those sorts of ethics as well that need to be considered.Eric Topol (42:07):And of those 40 some authors, do you around the world, do you have the sense that you all work together to achieve this goal? Is there kind of a global bonding here that's going to collaborate?Steve Quake (42:23):I think this effort is going to go way beyond those 40 authors. It's going to include a much larger set of people and I'm really excited to see that evolve with time.Eric Topol (42:31):Yeah, no, it's really quite extraordinary how you kick this thing off and the paper is the blueprint for something that we are all going to anticipate that could change a lot of science and medicine. I mean we saw, as you mentioned, Steve, how that deep visual proteomics (DVP) saved lives. It was what I wrote a spatial medicine, no longer spatial biology. And so, the way that this can change the future of medicine, I think a lot of people just have to have a little bit of imagination that once we get there with this AIVC, that there's a lot in store that's really quite exciting. Well, I think this has been an invigorating review of that paper and some of the issues surrounding it. I couldn't be more enthusiastic for your success and ultimately where this could take us. Did I miss anything during the discussion that we should touch on before we wrap up?Steve Quake (43:31):Not from my perspective. It was a pleasure as always Eric, and a fun discussion.Charlotte Bunne (43:38):Thanks so much.Eric Topol (43:39):Well thank you both and all the co-authors of this paper. We're going to be following this with the great interest, and I think for most people listening, they may not know that this is in store for the future. Someday we will get there. I think one of the things to point out right now is the models we have today that large language models based on transformer architecture, they're going to continue to evolve. We're already seeing so much in inference and ability for reasoning to be exploited and not asking for prompts with immediate answers, but waiting for days to get back. A lot more work from a lot more computing resources. But we're going to get models in the future to fold this together. I think that's one of the things that you've touched on the paper so that whatever we have today in concert with what you've laid out, AI is just going to keep getting better.Eric Topol (44:39):The biology that these foundation models are going to get broader and more compelling as to their use cases. So that's why I believe in this. I don't see this as a static situation right now. I just think that you're anticipating the future, and we will have better models to be able to integrate this massive amount of what some people would consider disparate data sources. So thank you both and all your colleagues for writing this paper. I don't know how you got the 42 authors to agree to it all, which is great, and it's just a beginning of something that's a new frontier. So thanks very much.Steve Quake (45:19):Thank you, Eric.**********************************************Thanks for listening, watching or reading Ground Truths. Your subscription is greatly appreciated.If you found this podcast interesting please share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths—newsletters, analyses, and podcasts—is free, open-access, with no ads..Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. And such support is becoming more vital In light of current changes of funding by US biomedical research at NIH and other governmental agencies.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research. Get full access to Ground Truths at erictopol.substack.com/subscribe

Es war die große Reichspolitik, die die Zeitungen vor einhundert Jahren, nach dem Tod von Reichspräsident Ebert, in Atem hielt. Aber auch in den Ländern und Kommunen standen natürlich weiterhin Entscheidungen, und eben dorthin lenkt das Hamburger Echo in seiner Ausgabe vom 5. März 1925 den Fokus. Bereits im Oktober 1924 war in der Hansestadt eine neue Bürgerschaft gewählt worden, in der die alte Koalition aus SPD und DDP seine Mehrheit knapp verloren hatte. Nach langen Verhandlungen hatte man deshalb getan, was auf Reichsebene nicht geklappt hatte, nämlich die rechtsliberale DVP mit ins ansonsten linksliberale Boot zu holen. Weshalb man in Hamburg als recht gutheißen sollte, was in Berlin nicht billig war, erläutert das Echo seiner sozialdemokratischen Leserschaft – und uns Rosa Leu.

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In the US overnight, Wall Street extended its losing run as fresh tariffs came into effect on Tuesday, US time. The Dow Jones fell by 1.55%, the tech-heavy Nasdaq lost 0.35% and the S&P500 ended the day 1.22% lower. Investors fear the global trade will impact the health of the US economy with retaliatory tariffs from China, Canada and Mexico in motion already.Over in Europe, markets closed lower as global investors brace for impact on the ongoing tariff war. The STOXX600 closed over 2.14% in the red, it's biggest daily drop since August last year. Germany's DAX fell 3.54%, the French CAC lost 1.85% and over in the UK, the FTSE100 closed Tuesday's trading session down 3.54%.The local market was sold off broadly yesterday as investor fears of Trump tariff implications spread through the ASX. The key index fell 0.58% as every sector aside from healthcare stocks ended the day in the red, with energy stocks taking the biggest hit with a more than 3% loss.What to watch today:The Australian share market is set to open lower, with the SPI futures suggesting a fall of 0.97% at market open this morning.In terms of economic news, GDP growth rate data will be released for Quarter 4 with a consensus and forecast of a 0.5% increase, 0.2% more than its previous result.On the commodities front this morning, Oil is trading 0.85% lower at 67 US dollars and 75 cents a barrel, gold is trading up 0.82% at 2914 US dollars an ounce and iron ore is trading 5.7% lower at 100 US dollars and 81 cents a tonne following the announcement of new US tariffs on Canada, Mexico and China now taking effect.Trading Ideas:Bell Potter maintains a buy rating on Develop Global (ASX:DVP) and has a 12-month price target of $4. With a current share price of $2.93, this indicates a share price growth of 36.5% over the next 12 months, hence the buy rating is maintained.Trading Central has identified a bearish signal on NAB (ASX:NAB), indicating that the stock price may fall from the close of $35.05 to the range of $28.50-$29.75 on a pattern formed over 8 days, according to the standard principles of technical analysis.

A bonus to having a group of adventurous friends is that every so often someone has a fantasy that they would like someone in the group (or in this case, the entire group!) to fulfill. A super sexy subplot to this year's Heaven & Hell Party at Tabu was that one of our friends wanted to have her first GangBang! So, of course, we obliged!As always, thanks for listening!Support the people who support this show:Shameless Care (promo code: SUITELIFE)Expansive Connection!Foambusters.com!Be sure to SUBSCRIBE, RATE, & REVIEW! We appreciate any and all feedback!Check out our show and MANY others on FullSwapRadio!How to stay in-touch with us:Email: thesuitelifepodcast@gmail.comFollow us here for info on upcoming LIVE episodes:Instagram: @thesuitelifepodcastTwitter: @suitelifepodFacebook: Livin' the Suite Life (Tryst Loq Suitelife)Don't forget to SUBSCRIBE to the Livin' the Suite Life Podcast YouTube Channel!

Welkom bij aflevering 414 van DVP. Voor de derde keer in vier confrontaties dit seizoen verloren we van Anderlecht. Pijnlijke zaak, en dit keer kunnen we het niet zozeer op den arbiter steken. Ik zal het dan maar op mezelf, de spelers, den trainer of mijn twee Kastaars van panelleden steken, en dat zijn vandaag Hans Bressinck en Kevin Baert. Host: Thomas SlembrouckGasten: Hans Bressinck, NIET Kevin Baert, maar WEL Yoni Van LooverenMontage: Thomas Slembrouck Hosted on Acast. See acast.com/privacy for more information.

„Politiker ohne Partei“ nannte Hans Luther seine 1960, zwei Jahre vor seinem Tod, erschienenen Memoiren, und tatsächlich war Luther als solcher in den Jahren der Weimarer Republik ein wesentlicher Faktor auf der großen politischen Bühne. Als Oberbürgermeister von Essen, als Reichsminister für Ernährung und Landwirtschaft sowie als für die erfolgreiche Einführung der Rentenmark verantwortlicher Reichsfinanzminister hatte er bereits amtiert, bevor ihn sein Weg Anfang 1925, als Chef einer Regierung aus Zentrum, DVP, DDP, BVP und DNVP, sogar ins Reichskanzleramt führte. Die Akzeptanz seiner Person reichte offensichtlich noch über diesen Parteibogen hinaus, weshalb ihm die Wilhelmsburger Zeitung auch diesen Karrieresprung zutraute. Ein kurzes Porträt des designierten neuen Regierungschefs in der Ausgabe vom 15. Januar zeichnet für uns Frank Riede.

After NASCAR drops a flurry of rules changes for the upcoming 2025 season, Jeff and Jordan take the green flag on a new season of The Teardown by sorting through all of them. From the controversial new "Open Exemption Provisional" to the revamped DVP policy, the guys share their opinion on how the new rules could impact NASCAR this year.

In der 16. Spezial-Ausgabe spricht Robert mit Alessandro über die Teilnahme von Helio Castroneves beim 67. Daytona 500, die Veränderungen beim Waiver für die Playoffs und die Revolution der DVP. ------------------------------------------------------------------Leftturnsonly.de ist DIE deutsche Fan-Adresse für NASCAR. Gemeinsam reden Robert, Alessandro, Daniel und Rob über Themen, die die NASCAR-Welt bewegen. Folge Leftturnsonly.de für Vorschau-Berichte, News, Liveticker und neue Podcast-Folgen. Podcast in Audioform Anchor, Apple Podcasts, Google Podcasts, meinsportpodcast.de, Spotify und auf allen gängigen Plattformen. Podcast im Video-Format Youtube - @leftturnsonly Social Media Instagram - instagram.com/leftturnsonly.de Twitter - twitter.com/LeftturnsonlyDE oder unter dem Hashtag #GermanHomeofNASCAR Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

In der 16. Spezial-Ausgabe spricht Robert mit Alessandro über die Teilnahme von Helio Castroneves beim 67. Daytona 500, die Veränderungen beim Waiver für die Playoffs und die Revolution der DVP. ------------------------------------------------------------------Leftturnsonly.de ist DIE deutsche Fan-Adresse für NASCAR. Gemeinsam reden Robert, Alessandro, Daniel und Rob über Themen, die die NASCAR-Welt bewegen. Folge Leftturnsonly.de für Vorschau-Berichte, News, Liveticker und neue Podcast-Folgen. Podcast in Audioform Anchor, Apple Podcasts, Google Podcasts, meinsportpodcast.de, Spotify und auf allen gängigen Plattformen. Podcast im Video-Format Youtube - @leftturnsonly Social Media Instagram - instagram.com/leftturnsonly.de Twitter - twitter.com/LeftturnsonlyDE oder unter dem Hashtag #GermanHomeofNASCAR Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

In der 16. Spezial-Ausgabe spricht Robert mit Alessandro über die Teilnahme von Helio Castroneves beim 67. Daytona 500, die Veränderungen beim Waiver für die Playoffs und die Revolution der DVP. ------------------------------------------------------------------Leftturnsonly.de ist DIE deutsche Fan-Adresse für NASCAR. Gemeinsam reden Robert, Alessandro, Daniel und Rob über Themen, die die NASCAR-Welt bewegen. Folge Leftturnsonly.de für Vorschau-Berichte, News, Liveticker und neue Podcast-Folgen. Podcast in Audioform Anchor, Apple Podcasts, Google Podcasts, meinsportpodcast.de, Spotify und auf allen gängigen Plattformen. Podcast im Video-Format Youtube - @leftturnsonly Social Media Instagram - instagram.com/leftturnsonly.de Twitter - twitter.com/LeftturnsonlyDE oder unter dem Hashtag #GermanHomeofNASCAR Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

Man kann den Einfluss des Bauhauses, der Kunstschule, die Walter Gropius 1919 in Weimar begründet hatte, auf Architektur, Design und diverse Avantgarden gar nicht unterschätzen. Dass die innovative Institution, die die Grenzen zwischen Handwerk und „hoher“ Kunst einriss und neue Formen des kollaborativen Studiums und der Lehre erprobte, von großer Wichtigkeit war, war schon so manchem Zeitgenossen bewusst. Die neue Landesregierung in Thüringen, angeführt von der DVP, jedenfalls wusste das Bauhaus nicht zu schätzen und bemühte sich darum, es abzuwickeln, unter anderem, indem die Mittel um 50 Prozent gestrichen wurden. Und auch als private Finanziers die Lücke schließen wollten, torpedierte sie diese Bemühungen. Sofort bewarben sich andere Städte, um das Bauhaus aufzunehmen, unter anderem Köln mit dem damaligen Oberbürgermeister Konrad Adenauer. Den Zuschlag sollte dann 1925 bekanntlich Dessau bekommen. In den Zeitungen finden wir Ende des Jahres 1924 wenige Erwähnungen dieses Prozesses, lediglich im Hamburger Echo vom 29.12. einen Zwischenbericht zu den Verhandlungen zwischen Bauhaus und Thüringen. Frank Riede liest für uns den Bericht über radikale Kürzungen bei etablierten Kulturinstitutionen.

Welcome to the In Bed With Alexa x GGD crossover episode! In this episode, sexologist Alexa Andre (@sexwithalexa) hosts her first threesome on the podcast with Vee and Elle, hosts of the Girls Gone Deep podcast, besties and lovers. They dive into their ENM (Ethical Non-Monogamy) journeys, recounting experiences at Hedonism and the play party where Vee and Alexa first met. Vee and Elle share how they met and their adventures in double penetration and double vaginal penetration. They provide tips for those wanting to try non-monogamy, discussing how to advocate for your pleasure and ask for what you want. Vee and Elle also talk about the vibrant non-monogamous community they have built together. Tune in for an open and enlightening conversation about pleasure, connection, and community in the world of ENM.How Vee and Elle met: Temptations lifestyle resort. (3:16)How Vee and Elle started the podcast. (7:23)Fucking older partners, and why women who advocate for their pleasure are sexy. (11:04)Penis sounding at a daytime orgy. (15:10)ENM journeys: how Elle got into the consensually non monogamous lifestyle. (22:33)Shame and the importance of community. (29:11)What are you curious about that you learned about through the lifestyle? DVP. (34:27)Faking Orgasms? How to get reconnected when you're in your head. (36:58)Tips for play parties: what to do when you're not the main part of the scene, and how to achieve orgasm with lots of people around. (43:22)DP: first time stories. (45:30)Anal: training and prepping. (51:28)Elle's and Vee's advice for new people discovering ENM. (54:01)Would you rather? (1:01:02)Where to find us, and how you can support us:Instagram: @girlsgonedeeppod Merch: girlsgonedeep.com/shopContact: girlsgonedeep@gmail.comWHOREible Life: Get 10% off your deck with code GONEDEEP at whoreiblelife.com Instagram: @wlthegameWoo More Play Affiliate Link: Support us while you shop!

In this episode, Elle and Vee debrief on the highlights, challenges and takeaways from their most recent weekend away with their ENM friends.  “A glimpse into a lifestyle party,” and one of the challenges of bringing a third to a party. (1:46)What's the point of having themes? (5:35)Sobriety: the challenges and benefits of staying sober for an entire lifestyle weekend. (9:10)Sobriety and sexuality. (18:02)Highlight: DP with strap ons? FFF threesome and goal-oriented fucking. (21:57)Face-sitting: the benefits of being distracted/focused when you're getting action both up top and down bottom. (26:46)Highlight: Fivesome and creampie. (29:41)Fuckit List item: DVP, and Elle's tips for success. (32:06)Breakthrough: Getting out of your head, and cumming in front of a group. (38:28)Sybian vs Fuck Machine. (41:37)Where to find us, and how you can support us:Instagram: @girlsgonedeeppod Merch: girlsgonedeep.com/shopContact: girlsgonedeep@gmail.comWHOREible Life: Get 10% off your deck with code GONEDEEP at whoreiblelife.com Instagram: @wlthegameWoo More Play Affiliate Link: Support us while you shop!

Ganz viele Stimmen gab es auf dem dünn besiedelten Helgoland nicht einzusammeln. Dennoch machten sich je ein Vertreter der SPD, der KPD und der DVP im Vorfeld der Reichstagswahl vom Dezember 1924 auf den Weg nach der einzigen deutschen Hochseeinsel und versuchten die Insulaner von ihren jeweiligen Ideen zu überzeugen. Wie das Rennen am Ende ausgegangen ist, verrät der mit T.H. zeichnende Sozialdemokrat unter ihnen in seinem Reisebericht im Hamburger Echo vom 15. Dezember nur mittelbar. Dafür erzählt er von den anscheinend etwas zirkusartigen Duellen, die sich die Kandidaten auf der Insel lieferten, aber auch von verbindenden Momenten im Angesicht der alle drei Festlandsgäste offensichtlich schwer beeindruckenden Elemente. Für uns auf die raue See der Natur wie der Politik gewagt hat sich Frank Riede.

Die Reichstagswahlen vom 7. Dezember 1924 hatten die Parteien der Mitte deutlich gestärkt. Um satte 5,5 Prozentpunkte hatte die SPD zugelegt, in geringerem Umfang galt das auch für DDP, Zentrum und DVP. Nationalsozialisten und Kommunisten hingegen mussten gegenüber den Wahlen im Mai große Verluste hinnehmen. Wer geglaubt hatte, dass sich nun die Regierungsbildung einfacher gestalten würde, sah sich gleichwohl getäuscht. Nach wie vor war unter den Koalitionären aus DDP, Zentrum und DVP umstritten, ob man sich nach links, zur SPD, oder nach rechts, zur DNVP hin erweitern wollte. Das alte Minderheitenkabinett unter Reichskanzler Wilhelm Marx hatte auf jeden Fall auch weiterhin keine Mehrheit, weshalb man dort zum Rücktritt entschlossen war und sich die Beobachter von der Wilhelmsburger Zeitung eher skeptisch dahingehend zeigten, bald zu stabileren Verhältnissen zu gelangen. Aus der Ausgabe vom 12. Dezember 1924 liest Rosa Leu.

She was known as the "Orgy Instigator" in college, and she's taken that energy to all new heights in the Adult industry.... Dustin welcomes Adult Film Star and OnlyFans Creator Nina Nova to the show this week and Nina isn't holding back. Like, not at all. She tells Dustin about how she plotted out full scale orgies in college, took on a creampie gangbang for one of her very first porn scenes, topped that one with a DVP scene, and worked with the one and only Creampie Cathy in a scene so wild, it has yet to be released. Nina loves to continuously up the ante and outdo herself, and that is abundantly clear towards the end of the episode, as she fully opens up about what she wants to do next. Brace yourselves. Welcome to EP 147: "Left Nelson" with Nina Nova Watch the video version of the show on YouTube YouTube: https://www.youtube.com/channel/UCIuCkOl_XummXVdu1t3XOuQFollow the showInstagram: https://instagram.com/sexparty.fm (@sexparty.fm)Twitter: https://twitter.com/sexpartyfm (@sexpartyfm)Follow Dustin Instagram: https://instagram.com/dustinrybka (@dustinrybka)Twitter: https://twitter.com/dustinrybka (@dustinrybka)Sex Party with Dustin Rybka

Der Liberalismus in Deutschland war bereits seit den Zeiten des Norddeutschen Bundes parteipolitisch gespalten und blieb dies auch in der Weimarer Republik. Während die Deutsche Volkspartei DVP als nationalliberale Vertretung des größeren Bürgertums galt, positionierte sich die Deutsche Demokratische Partei DDP eher linksliberal. Der alte einflussreiche Hamburgische Correspondent bekannte sich seinerzeit wiederum sehr klar zur DVP und unterstützte in den Debatten des Jahres 1924 unter anderem auch deren Kurs einer Öffnung der Berliner Regierungskoalition zu den Deutschnationalen. Entsprechend skeptisch beobachtete man den jüngsten Parteitag der dagegen opponierenden DDP. Wie der Correspondent den angeblichen Linkskurs der Demokraten kritisierte, weiß Rosa Leu.

Die Reichstagswahlen vom 4. Mai 1924 hatten die Parteien der politischen Mitte von SPD und DVP empfindlich geschwächt und die politischen Ränder – Deutschnationale und Völkische auf der rechten, die Kommunisten auf der linken Seite – erheblich gestärkt. Entsprechend schwierig gestaltete sich in der Folge eine Regierungsbildung. Die Koalition von Zentrum, DVP und DDP unter Wilhelm Marx hatte zwar bei weitem keine Mehrheit mehr, schaffte es aber immerhin, als Minderheitenkabinett den Dawes-Plan durch den Reichstag zu bekommen, der die deutschen Reparationszahlungen neu regelte, die deutsche Wirtschaft wieder kreditfähig machte und zur Grundlage eines schnell einsetzenden ökonomischen Aufschwungs werden sollte. In den Altonaer Neuesten Nachrichten vom 21. Oktober 1924 ist von diesem Kraftakt nichts zu lesen. Die Auflösung des Reichstages und die Entscheidung für Neuwahlen im Dezember kommentierte man hier eher polemisch mit einer Pauschalkritik an den gewählten Parlamentariern. Mehr dazu von Rosa Leu.

NASCAR Tripleheader at Talladega   Richard had an impressive victory in the Cup race, especially after a dramatic 28-car incident with just four laps to go that affected many top contenders, including Gumby Cindric.   We saw a lot of excitement around the DVP policy, along with some challenges in the pack and fuel mileage racing in a tight four-wide situation for a couple of hours.   As we look ahead to the Roval Cutoff, the points situation is definitely heating up.   Sammy Smith pulled off an amazing from-last-to-first performance with a timely win in Xfinity! Unfortunately, Sam Mayer faced some difficulties and was disqualified, while Allgaier is still working through his issues.   The points are really important as we approach the Roval.   In a heartfelt moment for Oldsmobile, Grant Enfinger secured their first win in Trucks and their first win in NASCAR since 1992! It's great to see most of the playoff drivers, except Nick Sanchez, making their way into the Top 14.   The points race is getting exciting as we head to Homestead.   IndyCar News   Michael Andretti has shared a thoughtful letter with fans as he transitions from his role as CEO of his team to Towriss.   Exciting news: the series plans to race in Arlington, TX, in 2026, around the iconic Cowgirls stadium and the Globe Life Field for the Rangers!   NFL Week Five is upon us, both in real life and fantasy, and we can't wait to recap our first matchup in the FallBrawl!   GSP Roundup   MotoGP has wrapped up its event in Japan, while NHRA had an exciting race in Dallas.   Supercars are gearing up for the Bathurst 1000, and there's a new format coming for 2025 that fans will love!   IMSA's Petit Le Mans is right around the corner, along with updates on teams and cars for 2025.   As we preview NASCAR Cup & XFinity at The Roval, it will be interesting to see who makes it to the round of eight!   Josh's Sim Segment   Show Close

The Big One is Coming and it certainly struck this past weekend at Talladega too! I hope everyone stays safe during Hurricane Milton as I know a lot of listeners will be effected. Hopefully this show will help take your mind off the incoming storm or help ease the clean up. We cover all the action from Talladega where a ton of lead changes, a close finish and the big one all made headlines. However the race was once again shrouded in controversy. What do you think of the DVP and Nascar's Inconsistency? We also Cover the Vermont Milk Bowl that took my attention both Saturday and Sunday providing two amazing days of racing! And we take a look at the results from Citrus County Speedway as they were able to get their show in this past weekend. Enjoy & Be SAFE! Talk to you again when we can!

**Episode 110: No Holds Barred an Unorganized Disaster** In this week's adrenaline-fueled episode of Race Car Spelled Backwards, we're ready to rev up the conversation and dive deep into the hard-hitting issues shaking the NASCAR world. This episode is anything but sugar-coated as we get fired up about the explosive lawsuit involving 23XI Racing and Front Row Motorsports against NASCAR—what it means for the future of the sport and the implications for teams and fans alike. We'll also dissect the chaos of the Talladega race, a spectacle that left fans questioning everything from race control to driver performance. With NASCAR making controversial changes to the DVP rules mid race that directly benefited Chase Elliott, we'll explore how these decisions could alter the competitive landscape and what it means for teams navigating the playoffs. And we can't forget about Daniel Suarez—tune in as we analyze his struggles early in the race and discuss whether he's running out of talent or simply facing a string of bad luck. Plus, we'll shine a light on the numerous rule infractions that seem to slip through NASCAR's fingers, raising eyebrows among drivers, fans, & insiders. As we wrap up, we'll celebrate the lucky victory of Ricky Stenhouse Jr., whose win at Talladega was anything but ordinary. Join us for an episode packed with passion, insights, and plenty of hot takes that will have you questioning the status quo in the world of racing. So buckle up, because this week's show is a wild ride you won't want to miss!

The guys are back this week after a very entertaining race at the Talladega Superspeedway! We discuss Stenhouse Jr's big win, the last lap and Kyle Larson, the damaged vehicle policy (DVP), and some more news on 23XI and Front Row Motorsports' lawsuit against NASCAR. All this and some more this week on the Fake Racers Podcast!

TJ Majors, Brett Griffin, and Freddie Kraft are back from Talladega to recap the first NASCAR Cup Series Playoffs race at the legendary superspeedway, with Andrew Kurland filling in as host. Ricky Stenhouse Jr. becomes the third different driver this post-season to play Playoff spoiler, how much chaos do surprise winners throw into the Playoff picture? Plus, NASCAR's decision to tow cars back to pit road certainly raised some eyebrows and made drivers sound off, when can we expect clarity on the DVP rule? And what really happened at the front of the pack between Austin Cindric and Brad Keselowski that led to the biggest wreck in NASCAR history? TJ shares his side of the story and who's really to blame.  Want more DBC? Check out and subscribe to the new DBC YouTube channel!

Denny Hamlin and co-host Jared Allen are back after an eventful race at Talladega. To decide the order of topics for the show, they brought out a wheel to spin and let it decide. The first topic of the day is the lawsuit 23XI and Front Row Motorsports filed against NASCAR (5:20). Denny explains why 23XI couldn't sign the charter agreement and the importance of why they are suing NASCAR.They also discuss the 11-team's decision to take two tires while others took fuel only (19:00), and whether Ricky Stenhouse Jr. should've been ruled part of the crash due to damage (25:00). Plus, why were the rules on Brad Keselowski and Chris Buescher not enforced?Next, they tackle teams being allowed to work on cars under a red flag, managing of DVP and cars being towed back had many people frustrated (32:25).Denny also breaks down the massive 25-car wreck (42:50), how Alex Bowman ruined Ryan Blaney's day (51:10), and Daniel Suarez's self-inflicted mistake (55:05).Finally, Denny and Jared look ahead to the final race of the round of 12 at the Charlotte Roval and the expectations are chaos.For more content head to our YouTube page: https://www.youtube.com/@ActionsDetrimental 

For the second week in a row, a non-playoff driver upsets the field! Speaking of upsets, several drivers previously impacted by the DVP rule felt frustrated when seeing two playoff drivers towed to pit road to fix damage caused by the big one. And, when I say “the big one”, I mean the biggest wreck in NASCAR Cup Series history, collecting 28 cars! Taylor Kitchen has a lot to discuss in this new episode of Above The Yellow Line! —  Help support those impacted by Hurricane Helene: https://www.redcross.org/donate/dr/hurricane-helene.html/   —  October is Dysautonomia Awareness Month -  Exclusive Merchandise: https://tinyurl.com/ycy4kejs Dysautonomia International: https://tinyurl.com/dwuaajud My Story: https://tinyurl.com/36mz8ej9 — From show creator Taylor Kitchen, welcome to Above The Yellow Line! Tune in each week to talk all things NASCAR with live streams most Thursday nights! Above The Yellow Line: www.abovetheyellowline.com  Toby Christie:  www.TobyChristie.com 

Wenn das Erstarken der politischen Ränder die Parteien der politischen Mitte zu lagerübergreifenden Koalitionen der großen Kompromisse nötigt, schwächt dies besagte politische Mitte erfahrungsgemäß häufig noch weiter und mündet schlimmstenfalls in einem Teufelskreis zunehmender demokratischer Instabilität. Nein, wir reden hier nicht über das Jahr 2024, sondern über das Jahr 1924, in dem die Reichstagswahl vom Mai keine klaren Mehrheiten hervorgebracht hatte. Die Regierungskoalition aus Zentrum, DVP und DDP unter Kanzler Wilhelm Marx benötigte wahlweise entweder die Unterstützung der geschwächten Sozialdemokraten oder der erstarkten Deutschnationalen, vermochte sich aber dauerhaft auf keine der beiden Optionen zu einigen. Der DVP-nahe Hamburgische Correspondent tendierte eindeutig zu einer Öffnung nach rechts und plädierte deshalb in seiner Ausgabe vom 5. Oktober als letztem Ausweg für Neuwahlen – nicht ahnen könnend, dass aus diesen im Dezember dann just die SPD als große Gewinnerin hervorgehen sollte. Es liest Frank Riede.

Dance Talk” ® with Joanne Carey and special guest, Sandra Rivera: Teaching Artist/Dancer/Guest Artist with Dances for a Variable Population  In this episode of “Dance Talk” ® with Joanne Carey, join host Joanne Carey as she chats with Special Guest, Sandra Rivera of Dances for a Variable Population. Sandra is a dancer, choreographer, educator, and writer and together they discuss Sandra's extensive career in dance, starting from her early influences in New York City to her involvement with Ballet Hispanico as an original member and up to her current impactful work with Dances for a Variable Population and the upcoming workshops and performances of DVP. Joanne and Sandra also discuss her work with Omega Dance Company. Their conversation highlights the importance of community engagement through dance, and the significance of creating inclusive spaces for older adults to express themselves through movement. They also discuss the role that her experience with liturgical dance held in Sandra's life. Sandra shares her insights on the transformative power of dance and its ability to foster connection and creativity across generations. Sandra Rivera has an extensive career as a dancer, choreographer and educator.  A founding member of Ballet Hispanico, she performed as a principal dancer creating a number of roles in the company's repertory. Since 1990 she has choreographed and performed contemporary dances with thematic content that reflects the Latino experience in the United States.  Artist-in-residence at the Cathedral of St. John the Divine with the Omega Dance Co. where she served as director.  Her solo dance portraits and choreographies have been presented at El Museo del Barrio, the Caramoor International Music Festival and the Abrons Art Center,the  Julia de Burgos Cultural Center, Aaron Davis Hall and the 92 Street Y.  She is on the faculty of Ballet Hispanico School of Dance and performs and is a teaching artist for Dancers for a Variable Population.  BA in Dance in the Latino Diaspora; CUNY's Baccalaureate for Unique & Interdisciplinary Studies.  Sandra Rivera  ⁠⁠https://www.sandrariveraprojects.com/biography⁠⁠ Find out more about Dances for a Variable Population and catch some of their upcoming performances and worksshops Oct 5th, 18th, Nov 16th https://www.dvpnyc.org/ Follow “Dance Talk” ® with Joanne Carey wherever you listen to your podcasts.  ⁠⁠⁠⁠https://dancetalkwithjoannecarey.com/⁠⁠⁠ Tune in. Follow. Like us. And Share.  Please leave us review about our podcast!  “Dance Talk” ® with Joanne Carey  "Where the Dance World Connects, the Conversations Inspire, and Where We Are Keeping Them Real."

Greg Brady and the panel of: Kim Wright, Founder and Principal of Wright Strategies , Brad Bradford, Toronto city councillor for Beaches - East York Mark Saunders, former Toronto police chief, mayoral candidate Discuss: 1-Who won the debate tonight? Harris beats Trump 2 -Taylor Swift endorses Kamala Harris after presidential debate 3 - City of Toronto rethinking plans for DVP construction one day after disruptive rollout  Learn more about your ad choices. Visit megaphone.fm/adchoices

Greg Brady and the panel of: Kim Wright, Founder and Principal of Wright Strategies , Brad Bradford, Toronto city councillor for Beaches - East York Mark Saunders, former Toronto police chief, mayoral candidate Discuss: 1-Who won the debate tonight? Harris beats Trump 2 -Taylor Swift endorses Kamala Harris after presidential debate 3 - City of Toronto rethinking plans for DVP construction one day after disruptive rollout  Learn more about your ad choices. Visit megaphone.fm/adchoices

DVP is back with another edge-of-your-seat, gripping, beyond entertaining episode of complete speculation and shitty takes. Starting with a new VLR rating that we seem to have heard before.... our thoughts after playing a couple games with Vyse, and a roster-mania segment including a player tier-list that is 100% objective and factual.Discord: https://discord.gg/n5eP3XxzuGSubreddit: www.reddit.com/r/drunkvalorantpodcast

Jane and Thor are into threesomes, swapping, cuckolding and more and they called in to talk all about it. How did they meet up? How did they first start hooking up with others? And where did they go to meet the people they hooked up with? Tune in for all the details which include how they were both married and cheating when they first met each other, the MFF threesomes they met at and how that threesome eventually led to them both divorcing and staying together, how and why Thor was immediately attracted to Jane, how they went crazy at first on swinger dating sites and swinger house parties, how and why they eventually became more selective as well as started to play alone, why they now prefer spontaneous hook ups over set up hook ups, the women they met that they both were totally into, the foursome they had on their staycation, their hook up with her co-worker that a started at a strip club, why they're not into hooking up with other swingers, the types of guys Jane is really into, her affair with a famous sports star and why that ended, their DVP experience and exactly what went down and a whole lot more. *REPEAT Originally aired 10/2022 To see anonymous pics of JANE AND THOR and my other female guests + gain access to my PRIVATE Discord channel where people get super XX naughty + hear anonymous confessions + get all the episodes early and AD FREE, join my Patreon! It's only $7 a month and you can cancel at any time. You can sign up here: https://www.patreon.com/StrictlyAnonymousPodcast To Join SDC and get a FREE Trial! click here: https://www.sdc.com/?ref=37712 or go to SDC.com and use my code 37712 Want to be on the show? Email me at strictlyanonymouspodcast@gmail.com or go to http://www.strictlyanonymouspodcast.com and click on "Be on the Show" Have something quick you want to confess while remaining anonymous? Call the CONFESSIONS hotline at 347-420-3579. You can call 24/7. All voices are changed. Sponsors: https://bluechew.com/ Get 15% OFF Blewchew plus first-month FREE use code STRICTLYANON https://www.dipseastories.com/strictlyanon Hear the hottest stories on Dipsea! 30-day FREE TRIAL https://viiahemp.com/ Have great sleep AND great sex with VIIA Hemp Gummies used code: STRICTLYANON for 15% off https://butterwellness.com/ Get 20% OFF your Butter Wellness prostate massager, use code STRICTLY http://www.shamelesscare.com/strictly You can get one year supply of Doxypep for just $109 Follow me! Instagram https://www.instagram.com/strictanonymous/ Twitter https://twitter.com/strictanonymous?lang=en Website http://www.strictlyanonymouspodcast.com/ Everything else https://linktr.ee/Strictlyanonymouspodcast Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Elle and Vee catch up and discuss their takeaways from two sex party events their friend group (the Joy Fam) threw, including recapping sexy stories, "a-ha" moments and reflections. Implementing Lessons Learned: change your environment and have vacation sex! (0:33)House of Love club night takeaways: Vee's birthday celebration, and Elle's first big night out since having a baby! Getting over new mom nervousness with costumes: How themes get you into the sexy mood - especially animal theme :) (3:56)How to feel confident while carrying baby weight: MILK PLAY! Break the touch barrier by using breast milk play as an ice breaker? (5:56)Sexy Story with The Greek: what makes a good single male in the lifestyle? Wolf energy. (11:11)Feeling overwhelmed at a sex party when you're the guest of honor, taking a backseat but staying involved. (18:27)Joyunion: sex friends getting together with babies - it's different but the same! (20:46)TIP: how to get sexual if you're not sure if you're horny. Getting turned on by hearing another woman orgasming. (23:27)Sexy story: Pushing past your own limits. Elle orgasms twice when she thinks she can only do it once. (27:13)CREAM PIE STORY: Trying to do TVP (triple vaginal penetration), DVP (double vaginal penetration) and cream pies. (29:33)TIP: take 5 minutes away from the overstimulation of the party to let your body relax and your dick to get hard. (31:46)TAKEAWAY: The problem with peeing in the middle of the orgy. (34:26)TAKEAWAY: The best orgy snack, and issues with dry mouth. (37:00)Being a mom in an orgy and getting distracted during play.  How to re-center yourself and focus on your body and sensations. (39:36)Listener question: Our book recommendations for jealousy! (43:34)Where to find us, and how you can support us:Instagram: @girlsgonedeeppod Merch: girlsgonedeep.com/shopContact: girlsgonedeep@gmail.comWHOREible Life: Get 10% off your deck with code GONEDEEP at whoreiblelife.com Instagram: @wlthegameWoo More Play Affiliate Link: Support us while you shop!

Die Hamburger Volkszeitung war seit 1920 das Blatt der Kommunistischen Partei in der Hansestadt. Entsprechend wenig erstaunlich ist es, dass im heutigen Bericht vom 11. August 1924 über eine neuerliche Konferenz zwischen Deutschland und den Siegermächten über die Frage der Kriegsreparationen weder Zentrums-Kanzler Marx, noch Außenminister Stresemann von der DVP, noch die Regierungspolitiker der bürgerlichen Demokratien England und Frankreich wirklich gut wegkommen. Das politische Vorbild – die Überschrift „Russisch antworten“ macht es deutlich – sitzt natürlich in Moskau, wo die Sowjetführung es im Unterschied zu der deutschen Regierung angeblich verstehe, Handelsverträge mit den Westmächten zu ihren Bedingungen aufzusetzen. Interessant an diesem Artikel ist außer der alten Frage „Wie hältst du es mit dem großen Nachbarn im Osten?“ auch die Autorin: Ruth Fischer, ältere Schwester des Komponisten Hanns Eisler, war eine der prominentesten Vertreterinnen des sogenannten linken KP-Flügels und ab 1924 sogar kurze Zeit Parteivorsitzende. Als solche trieb sie eine Bolschewisierung der Partei voran, überwarf sich allerdings bald schon mit Stalin und wurde aus der KPD ausgeschlossen. Von Nationalsozialisten wie Stalinisten erbittert bekämpft, lebte sie später in französischem und US-amerikanischem Exil. Es liest Rosa Leu.

Bill Beament grew up in a working class family out of Esperance in Western Australia. He dreamed of being a general manager of a mine one day. Instilled at a young age with a deep work ethic and an acute commercial sense, he achieved much, much more than this as CEO and Executive Chair of Northern Star. Bill reshaped the underground gold mining industry and built from scratch a $16b, ASX 50 behemoth. Not resting on his laurels though, Bill has more recently turned his attention to wrapping up all his learnings about mining, about people and about leadership to his own venture Develop Global (ASX:DVP), which is on the precipice of replicating Northern Star's success in critical minerals with its unique business model of both mining services and mine ownership. This is one of Australia's great stories, largely unknown and untold outside the resource community so heavily centred in Perth, but the scaling lessons, as you'll hear, are applicable to all sectors and leaders of businesses, of all shapes and sizes. This episode takes you underground into a world unfamiliar to most, but applicable to all. I hope you enjoyed this episode of Scaling Up with Bill Beament, CEO and founder of Develop Global.  Show Notes: CHAPTERS:   (00:55): Bill's upbringing in country WA (04:09):  Starting in the underground industry   (06:19): Lessons from Barminco  (09:11): Building Northern Star    (14:03): What makes a world-class underground mine operator (18:48): Operational excellence at Northern Star and starting Develop Global    (24:23): Unearthing critical minerals   (29:14): DVP's business model (32:34): Buying Woodlawn mine (35:59): Best in class hiring and retaining talent (41:47): Remuneration philosophy

Amanda and Johnny are into MFM threesomes, reclaiming s-e-x, chastity, and more and they both called in to talk all about it. When and how did they first start having threesomes? What exactly went down at their first one? And, how did it progress to them being a full-on cuck and hotwife couple? Tune in to find out plus hear Johnny explain how he felt the first time his wife had sex with another guy, what about it turned him on, how he's 100% not jealous, the rough patch they went through when they tried full swaps, why he loves reclaiming sex and being the “clean up guy,” the videos and audio recordings he gets from his wife while she's with over guys and why he loves that so much, why he looks for guys that are bigger and better than him for Amanda to hook up with and more. And then, Amanda explains the first MFM threesome she had before she was married, how she felt about hooking up with other guys at first, what she enjoys about it now, how and why she's not into full swaps, why she loves being with two men at the same time so much, her DP and DVP experiences and why she's now a size queen, the stranger sex she had a hotel and exactly what went down, how she stays safe, who she tells and doesn't tell about her lifestyle, why it works for them and a whole lot more. REPEAT EPISODE - originally aired 10/22 **To see anonymous pics of AMANDA & JOHNNY plus see anonymous pics of my other female guests + gain access to my PRIVATE Discord channel where people get super XX naughty + hear anonymous confessions + get all the episodes early and AD FREE, join my Patreon! It's only $7 a month and you can cancel at any time. You can sign up here: https://www.patreon.com/StrictlyAnonymousPodcast To Join SDC and get a FREE Trial! click here: https://www.sdc.com/?ref=37712 or go to SDC.com and use my code 37712 Want to be on the show? Email me at strictlyanonymouspodcast@gmail.com or go to http://www.strictlyanonymouspodcast.com and click on "Be on the Show" Have something quick you want to confesss while remaining anonymous? Call the CONFESSIONS hotline at 347-420-3579. You can call 24/7. All voices are changed. Sponsors: https://www.dipseastories.com/strictlyanon Hear the hottest stories on Dipsea! 30-day FREE TRIAL https://butterwellness.com/ Get 20% OFF your Butter Wellness prostate massager, use code STRICTLY http://www.shamelesscare.com/strictly You can get one year's supply of Doxypep for just $109 https://viiahemp.com/ Have great sleep AND great sex with VIIA Hemp Gummies used code: STRICTLYANON for 15% off https://bluechew.com/ Get 15% OFF Blewchew plus first-month FREE use code STRICTLYANON https://promescent.com/strictlyanon Want to have better S-E-X?! Use Promescent 15% OFF your WHOLE order Follow me! Instagram https://www.instagram.com/strictanonymous/ Twitter https://twitter.com/strictanonymous?lang=en Website http://www.strictlyanonymouspodcast.com/ Everything else https://linktr.ee/Strictlyanonymouspodcast Learn more about your ad choices. Visit megaphone.fm/adchoices

Elle had her baby! In this episode, she shares all the intimate details about how she and her husband, M, used natural sexual tactics to induce labor, and how they got back to being sexual after six weeks of healing. How to induce labor with sex: nipple play, penetrative sex, nipple clamps, orgasms and Braxton Hicks. (3:07)What is labor pain like? Comparing contractions to DVP, speculum spreading, fisting, anal discomfort: breathing through discomfort, and thinking of words as spells. (11:04)Post-baby vagina: "the husband stitch", and does it look different? Is it loose? (17:31)Postpartum sex: how long does it take to get back to sex after having a baby? Getting over the fear of having an orgasm. How to get comfortable with penetration again. The first orgasm after six weeks of vaginal healing. (20:43)Scheduling sex when you have a newborn. (28:09)Breast milk play: Breastfeeding and nipple play. Tasting breast milk and squirting it during blow jobs. (28:41)Being in the open lifestyle and parenthood: confidence issues with postpartum body. Diving back into sex parties and ENM (ethical non-monogamy) after having a child. (35:40)Maintaining your sex life with a baby around. How having a short timeline can be hot! (38:34)Major takeaways from giving birth and getting back to sex: Prioritizing sex to reignite sexuality in your relationship postpartum. Falling in love with your partner again. (42:01)Where to find us, and how you can support us:Instagram: @girlsgonedeeppod Merch: girlsgonedeep.com/shopContact: girlsgonedeep@gmail.comWHOREible Life: Get 10% off your deck with code GONEDEEP at whoreiblelife.com Instagram: @wlthegameWoo More Play Affiliate Link: Support us while you shop!

The Riot devs finally took a que from this podcast and implemented pretty much exactly what we said to nerf Viper. Too bad they didnt listen to the whole episode and they fucked up Cypher at the same time. The moral of the story: listen to DVP.Discord: https://discord.gg/n5eP3XxzuGSubreddit: www.reddit.com/r/drunkvalorantpodcast

1. Everybody wins in this episode! We are invited to Desire by some dear friends and experience the new Eden resort. Surprise Richard, you are getting pegged for your birthday!2. First night at Desire, Richard volunteers Lauren for DVP with the right couple, wrong piece of junk.3. Richard's DVP studies have him calling out positions like training camp. Why does it always look so simple when the pros do it?4. Lauren saddles up and makes it for a total of 11 seconds. However, she did not win a fancy belt buckle. She did win by taking SHIVERS! Go try some and see for yourself. Save 10% with promo: R77 at checkout!5. We meet another couple by the pool, dart up to the day beds for a quickie, then head for a nice lunch. Maybe they are down for pegging?6. We go dancing with Richard and understand what he's actually yelling about on the dance floor.7. Intrigued by the new couple, we go for round two! This time it's so manly, Lauren is sent spinning into multiple orgasms.8. Richard shares his tips for guy on guy play and why he's still straight after #nohomogaystuff.#gaping #NeonPartyRemix #barebackskate #ONLYFANS---------- Support us with:Patreon Help us #keepitupBook your Desire / Temptation /Hedo trip* with Lauren and get a free Bikini Addiction bikini!++NEW NEON PARTY REMIX COLOR IS OUT NOW! Grab yours and save 10% with code: ROOM77 at Bikiniaddiction.com #DontLetTheKarensWin

Join us for a conversation about reducing violence in Oakland and how we can all work together to keep each other safe.  Pastor Billy Dixon leads At Thy Word Ministries and is co-chair of the Board of Directors of Faith in Action East Bay. He is an Oakland native and the son of a pastor. Dixon joined the U.S. Navy before becoming a correctional officer for 28 years. Later he attended seminary at Southwest Bible College, and in 2010 he took over the church his father had founded, At Thy Word Ministries. Dr. Holly Joshi is the City of Oakland's chief of violence prevention. She has vast leadership experience and a track record of successfully implementing evidence-based, violence prevention and intervention strategies. Prior to taking on leadership of the Department of Violence Prevention (DVP), Dr. Joshi served as senior director at GLIDE, a nationally recognized center for social justice, dedicated to fighting systemic injustices, creating pathways out of poverty and crisis, and transforming lives. At GLIDE she led the Center for Social Justice, a department focused on improving housing access, community health and safety, and gender and racial equity. Taking on the leadership of the DVP is a homecoming for Dr. Joshi who worked for the city from 2001–2015, holding diverse investigative and leadership roles within the Oakland Police Department, including child exploitation unit supervisor, Internal Affairs Division investigator, crime reduction team investigator, public information officer, and chief of staff. In this work she was widely recognized for her expertise in gender-based violence, commitment to progressive policing, and collaborative relationships across the city. Captain Frederick Shavies is the acting captain of Ceasefire. He is an 18-year veteran with the Oakland Police Department and a graduate of the 283rd FBI National Academy. Captain Shavies is an Oakland native who is passionate about reducing violence in his community. See more  Michelle Meow Show programs at The Commonwealth Club of California. Produced in partnership with Fluid 510. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Daily Gwei Refuel gives you a recap every week day on everything that happened in the Ethereum and crypto ecosystems over the previous 24 hours - hosted by Anthony Sassano. Timestamps and links to topics discussed: https://daily-gwei-links.vercel.app/recent 00:00 Introductory song 00:41 Several democrats push back against ETFs & ETPs https://twitter.com/NateGeraci/status/1768433569200803860 04:46 Crypto voters leaned to Biden in '20 but now lean Trump  https://twitter.com/JBSDC/status/1768348720838643771 07:25 Market size for spot ETH ETF potentially as big/bigger than spot BTC says Van Eck rep  https://twitter.com/NateGeraci/status/1768436093030948907 09:41 Coinbase will apparently pursue legal action against SEC if ETH ETF denied https://twitter.com/econoar/status/1768449108321444226 12:29 ACDE #183 agenda  https://twitter.com/TimBeiko/status/1768377163554897955 13:36 Dan Finlay's support for EIP-3074 account abstraction https://twitter.com/danfinlay/status/1768291044683288808 14:55 EigenLayer Mainnet journey begins https://twitter.com/eigenlayer/status/1768269792149131396 17:38 R&D Roadmap for Obol the DVP protocol/network https://twitter.com/ObolNetwork/status/1762521018671698284 19:36 Update on donations that came in from the Dencun POAP https://warpcast.com/kodys.eth/0x83d49750 20:51 OP Chains' post-upgrade onchain costs by the source of fees https://twitter.com/MSilb7/status/1768403584612233291 21:52 Total blob fees going up on Base but still ~10x lower than pre-upgrade https://twitter.com/will__price/status/1768265984790425651 24:51 Blobs & Atlas upgrade arrive on Arbitrum https://twitter.com/arbitrum/status/1768306107318178061 29:29 Chart of Blob gas price and blob burn https://twitter.com/ultrasoundmoney/status/1768550429279814072 30:39 Rabby is abstracting away L2 user-experience pain https://twitter.com/econoar/status/1768414112961437772 32:41 A brief thread on 4844 and block building https://twitter.com/bertcmiller/status/1768229920268791941 34:12 Devcon venue announced Thailand venue https://twitter.com/EFDevcon/status/1768269388279640405 This episode is also available on YouTube: https://youtu.be/kco1sZLcjXo Subscribe to the newsletter: https://thedailygwei.substack.com/ Subscribe on YouTube: https://www.youtube.com/channel/UCvCp6vKY5jDr87htKH6hgDA/ Follow Anthony on Twitter: https://twitter.com/sassal0x Follow The Daily Gwei on Twitter: https://twitter.com/thedailygwei Join the Discord Channel: https://discord.gg/4pfUJsENcg DISCLAIMER: All information presented across all of The Daily Gwei's communication channels is strictly for educational purposes and should not be taken as investment advice.

In the latest episode of AbbottTalks, Abbott Cardiovascular's leaders, Christopher Piorkowski, MD, DVP and Chief Medical Officer of Electrophysiology, and Dan Kaiser, Divisional VP Product Development, Electrophysiology, delve into the vast landscape of electrophysiology and the comprehensive approach Abbott is taking towards atrial fibrillation (AFib) treatment. The conversation highlights a potentially innovative pulsed field ablation (PFA) technology and Abbott's broader AFib portfolio, showcasing a commitment to revolutionizing cardiac arrhythmia management. While the Volt™ Pulsed Field Ablation System could represent a significant leap forward with its unique capabilities for creating precise and tissue-selective lesions, Piorkowski and Kaiser emphasize the diversity and depth of solutions Abbott is developing. This includes advancements in diagnostic tools, patient monitoring, and a range of therapeutic approaches designed to offer customized and effective treatment pathways for individuals with AFib. By focusing on a holistic view of patient care, they discuss how Abbott aims to improve clinical outcomes through technological innovation and enhance patients' quality of life by making treatments more accessible, reducing procedure times, and addressing the broad spectrum of needs within the electrophysiology community. With ongoing clinical trials and research, Abbott is positioned at the forefront of addressing the unmet needs in AFib management, underlining the company's commitment to continuous innovation and patient-centered care. Thank you to Cretex Medical for sponsoring this episode of AbbottTalks. For more information on how Cretex Medical works with medical device companies, visit www.cretexmedical.com. Thank you for listening to the AbbottTalks Podcast. Tune in and subscribe to DeviceTalks on all major podcast channels to never miss an episode.

In today's episode, Elle and Vee bring back guest Jess from Episode 37: Edging, to play the game WHOREible Life together! This conversation perfectly displays how WHOREible Life the game facilitates a little bit of the naughty chat with a little bit of the DEEP! When we pulled a card, each of us responded with Done it, Fantasy or No Thank you. 1 Done it —with story sharing2 Fantasy —-with desire share3 No thank you --and why notAss swallowing butt plug experience. (1:00) Toy Review: Amovibe Pro+G Spot Flapping Vibrator with Kissing Function & Vibrating Tongue. (6:15) NEW with GGD:  New Episode series launch: Why WHOREible Life? (12:55) First WL card: “Take a sip for every person you have peed on.” Thoughts are shared around the psychology of what brings on the kink of pee play. (15:19)Second WL Card: “Been Fisted” and overcoming the idea of, “yeah right, a hand won't fit in there”  (24:34) How to stay focused on your current partner(s) without getting distracted in a group play situation. (28:42)No pressure to perform leading to organic sexual play. (33:53)How Jess and Ace evolved into separate play. (36:12)Vee shares her first fisting experience. (37:15)Looser pussy with DVP and solving the triple penetration logistical problem. (42:50) EXCITING NEW UPDATES WITH GGD: A website, merch shop, & Slutstakes. (45:54) Support the showInstagram: @girlsgonedeeppod Contact: girlsgonedeep@gmail.comWHOREible Life: Get 10% off your deck with code GONEDEEP at whoreiblelife.com Instagram: @wlthegameWoo More Play Affiliate Link: Support us while you shop!