Podcasts about pnn

In Episode 140 of the Diary of a UK Stock Investor Podcast this week:- (00:00) Show Start (01:38) Supporting The Podcast (03:15) An Update on The Discord Group (08:25) Messages from our Listeners (15:18) UK Stocks Latest News, HVO, PNN, QQ., WIZZ, BATS & GLE (23:22) Danny DeVito on Value Investing (26:13) Becoming a Stocks & Shares ISA Millionaire (31:25) Analysis of International Consolidated Airlines Group [LSE: IAG] Drop us a COMMENT here on Spotify or Email Chris at the show on chris@chrischillingworth.com Diary of a UK Stock Investor Podcast is a show for everyday long-term retail investors, hosted by Chris Chillingworth. The podcast is unique in that it serves as a place for Chris to reflect on the highs and lows of long-term UK stock investing, as well as sharing detailed updates on how his own portfolio is growing. With new episodes every Thursday, and a detailed update on his quest to reach £1,024,867 in portfolio value by 2043, episodes often discuss investing education, strategy, mindset, ideas and even stock picks and analysis. The show, which now has an active following of over 4000 downloads a month, is curated by Chris Chillingworth, a UK investor for over a decade whose stockpicks have achieved a 18% annual average return between Jan 2014 - Nov 2024. Email Chris at the show on chris@chrischillingworth.com Checkout the website https://chrischillingworth.com 

Everyone is trying to unlock Artificial Intelligence's promise. We have seen generative AI tricks that can summarize long documents in a flash, which is substantially different from the requirements of serious federal research. Today, we examined some challenges scientific communities experience in applying AI. Quentin Kerilman from the PNN labs throws some icy water on AI enthusiasts when he cautions that using AI for many sensitive applications has no framework. Leaders must use their best judgment when including data sets in projects. Ramesh Menon from the DIA warns that careful data collection must still be used. For example, one must use fair, unbiased data. Is the AI appropriately documented? Further, a scientist will always need multiple data modalities. When used in AI, it needs to be appropriately tagged. Medical data has much theoretical value from AI. But this is the exact data that has double and triple protection. What about leaks and backdoors? Despite all the challenges presented, transparency, human oversight, and collaboration were emphasized to ensure AI's practical and responsible use.  

Nos acompaña de nuevo Natalia Giraldo Jaramillo, investigadora que ha explorado profundamente las relaciones sagradas y territoriales de los cuatro pueblos serranos: Kággaba (Kogui), Iku (Arhuaco), Wiwa y Kankuamo, quienes habitan y protegen la Sierra de Gonawindúa, conocida comúnmente como la Sierra Nevada de Santa Marta. En este episodio además de Natalia Giraldo participan algunos asistentes,en orden de aparición Natalia Giraldo, Patricia Noguera Maestre -del Consejo Laboral Afroamérica capítulo Magdalena-Luz Elvira Angarita-ex-directora de la Territorial Caribe de PNN; Jeferson Rojas jefe de PNN Portete. La imágen de esta portada es de Ismael Reyes Payán:.

   Donnie the Destroyer is a new feature on PNN. In the middle of this political season where tensions are at astronomical levels, the need for levity and humor is strong. Now, I'm sure that Trump enthusiasts will not find this little ditty 'amusing,' but their sensitivities are unimportant.    Enjoy this first short episode! 

In this groundbreaking episode of the Cognitive Revolution, we explore the intersection of AI and biology with expert Amelie Schreiber. Learn about the advances in drug design, protein network engineering, and the unfolding AI revolution in scientific discovery. Discover the implications for human health, longevity, and the future of biological research. Join us as we delve into an exciting conversation that may redefine our understanding of biology and medicine. SPONSORS: Oracle Cloud Infrastructure (OCI) is a single platform for your infrastructure, database, application development, and AI needs. OCI has four to eight times the bandwidth of other clouds; offers one consistent price, and nobody does data better than Oracle. If you want to do more and spend less, take a free test drive of OCI at https://oracle.com/cognitive The Brave search API can be used to assemble a data set to train your AI models and help with retrieval augmentation at the time of inference. All while remaining affordable with developer first pricing, integrating the Brave search API into your workflow translates to more ethical data sourcing and more human representative data sets. Try the Brave search API for free for up to 2000 queries per month at https://bit.ly/BraveTCR Head to Squad to access global engineering without the headache and at a fraction of the cost: head to https://choosesquad.com/ and mention “Turpentine” to skip the waitlist. Omneky is an omnichannel creative generation platform that lets you launch hundreds of thousands of ad iterations that actually work customized across all platforms, with a click of a button. Omneky combines generative AI and real-time advertising data. Mention "Cog Rev" for 10% off https://www.omneky.com/ CHAPTERS: (00:00:00) Introduction (00:04:53) Introduction to Amelie Schreiber and the Podcast (00:08:59) Understanding Protein Interactions (00:11:45) Traditional Methods vs. AI Approaches (00:13:51) Molecular Dynamics and AI Models (00:18:02) AlphaFold and Protein Structure Prediction (00:18:43) Sponsors: Oracle | Brave (00:20:51) Protein Dynamics and New AI Models (00:32:36) Sponsors: Squad | Omneky (00:34:22) Challenges in Protein Interaction Models (00:44:44) Generalization and Data Splitting in AI Models (00:48:43) Advanced AI Models for Protein Complexes (00:52:25) Practical Applications of AI in Biochemistry (01:01:53) Designing Protein Sequences with Ligand and PNN (01:05:19) Binder Design and Fold Conditioning (01:08:48) Challenges and Bottlenecks in Drug Discovery (01:16:09) Adoption and Accessibility of New Technologies (01:21:04) Future Prospects and Ethical Considerations (01:37:08) The Role of AI Agents in Biological Research (01:40:18) Balancing Innovation and Safety in Biotechnology

     The Atlantic meridional overturning circulation (AMOC) current brings warm air to the EU resulting in warmer climates than you would expect so close to the Arctic. Unfortunately it is coming closer to collapse which could result in climate disasters only seen in Hollywood epic movies. Today on the Environmental Justice Report, I will discuss this looming disaster in terms of climate crimes and corporate responsibility. That is our first story.  Our second story is about Trump's latest stump speech where he openly heralds his "final solution" to globalists and other boogey men. The story will deal with the planned complicity of corporate media.  We will also have our Deplorable segment as well as our Jackass of the Week Award.  Come join me for this double feature of PNN and EJR! Jeanine

     This week I  am going to discuss the Gish Gallop aka how to shovel BULLSHIT as fast as possible in the poltiical sphere--and how to counter it. Trump and his GOP have become experts at the art of throwing bullshit at opponents. They do it to avoid the public discovery that Trump knows NOTHING. This propaganda technique is also known as the Gish Gallop. It has been used by fascist parties for decades and now the GOP of Trump has embraced it for the last 7 years as its unofficial pledge to duty.   We have a new initiate into PNN's DEPLORABLE List.  The Jackass of the Week Award will also be announced!  

     This week on PNN, I will discuss the asinine statement made by JP Morgan CEO Jamie Dimon, where he admonishes Trump MAGA critics. Dimon said in Davos that we shouldn't 'demonize' MAGA. Dimon then praised Trump for his alleged accomplishments. Apparently, MAGA supporters terrorizing the rest of us is little more than an inconvenience to Dimon, so I decided to investigate Dimon. Should be interesting.  Our latest DEPLORABLE and Jackass of the Week will be revealed.  Come join me.    Jeanine

    This show SHOULD have aired last Sunday, but BlogTalkRadio was having a 'nervous breakdown.' This episode challenges the ludicrous narrative coming from the Trump camp--the asinine idea that the president has 'absolute immunity. We will discuss the deluded and tortured argument for 'absolute presidential immunity' from criminal prosecution, its dubious history, and its danger to democracy itself. In theory at its most extreme application, under this doctrine a president could call an opponent into the Oval Office, put a gun to their head, pull the trigger, then demand the janitor clean up the mess without ever being held criminally accountable. This is the spectre of absolute presidential immunity that Donald Trump is demanding, which the Supreme Court could allow. This is our big story.  We will also mention how Project 2025 is relying on this garbage theory.  We have a new initiate into PNN's DEPLORABLE List.  The Jackass of the Week Award will also be announced!

This week on PNN, I will discuss the republican attacks on voting rights. Whether you are more interested in environmental issues as opposed to voting rights, this issue affects all others. The GOP knows they can't win elections legitimately so they attack voting rights. Just a week ago, the 8th Circuit Court of Appeals based in St. Louis struck down another major protection that was formerly in the Voting RIghts Act of 1965. I will discuss. This is our big story.  We will have another installment of our series covering Project 2025--the republican blueprint to establish a presidential dictatorship.  And, we will have our Jackass of the Week Award!  Come join me. Jeanine

    This week on PNN, I am speaking about censorship in our K-12 schools, universities, and public libraries--all in the name of alleged 'parent rights.' The title of this week's show is "Free speech vs parent's rights--aka--democracy vs bigotry, reflects the ugly truth of the times. GOP conservatives have embraced open bigotry--now comfortable "saying the quiet part out loud." The GOP of Trump celebrates racism, misogyny, religious bigotry (including anti-semitism), homophobia, transphobia, and anti-intellectualism. They have embraced neo Nazism. They are the new Confederacy and Jan. 6th was the 21st century form of Fort Sumpter. I will talk about heroic teachers and moronic politicians. I will also speak to Trump's latest threats--including a death threat against retiring General Mark Milley--and anyone else who dared to criticize his majesty.  We will have another segment of "My Little Margie" and of course the Jackass of the Week Award.  Come join me.  Jeanine

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.04.551957v1?rss=1 Authors: Hidalgo-Cortes, J., Manas-Ojeda, A., Olucha-Bordonau, F. E., Garcia-Mompo, C., Castillo-Gomez, E. Abstract: Major depression is the most prevalent neuropsychiatric disorder in elderly population, affecting more than 20% individuals over 60 years old, especially women. In this age range, social isolation is a major risk factor for depression. While there is a significant positive association between social isolation and depression in the elderly population, the neurobiological basis of this association is complex and still poorly understood. Evidence from animal models and human studies indicates that neuroplasticity, especially that of limbic brain regions, is impaired in depression but, till date, scarce studies address this question in older population. In this regard, animal models devoid of human cultural connotations represent a crucial tool. In the present study, we investigated the impact of chronic isolation stress (CIS) and a subsequent resocialization period in aged male and female mice (~ 21 months-old), focusing our attention on affective symptoms and the plasticity of parvalbumin-expressing (PV+) neurons in the lateral/basolateral amygdala (LA/BLA). We found that CIS impaired affective behaviour and LA/BLA plasticity only in females. Specifically, CIS induced depressive-like symptoms and decreased the integrity of perineuronal nets (PNN). Resocialization effectively rescued all these impairments. Old males were not affected by CIS but in social conditions showed higher PNN integrity (less plasticity) than females. All together, our results demonstrate that old females are less resilient to CIS than old males and point to the integrity of PNN in the LA/BLA as a key regulator of depressive-like symptoms induced by social isolation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

This week on PNN, I will discuss the systemic child abuse and child reckless endangerment on the Texas border along the Rio Grande River, sponsored by Governor Greg Abbott. Governor Abbott ordered DPS (Texas Department of Public Safety) officers to push the small children and babies of migrants back into the treacherous waters of the Rio Grande River. He has also ordered troopers to deny small children any water in 100+ degree temperatures. Besides being an obvious and egregious human rights violation, Governor Abbott's orders could be interpreted as child abuse and reckless child endangerment. In spite of this obvious abuse, social workers in Texas--do NOTHING. No adult should be granted the right to abuse any child, and that includes governors and presidents. This rapidly evolving story is our first segment. Our second segment deals with the revocation of laws forbidding abusive and dangerous child labor. The GOP of Trump has rushed to embrace child labor with no limitations. It is ironic that the GOP claims to be the "pro-life" party, while pushing such evil and inhumane policies. I will discuss.  My Little Margie is BAACK! What will our little blonde neandethal do next?!  And of course we have the 'Jackass of the Week Award,' along with the erudite stylings of Randy Rainbow. Come join me. Jeanine

This week, in the damp, dark BRIG, we've tossed the multi-talented Killarney Traynor! Aside from having a crazy cool name, Killarney is a New England-born actress, novelist, stunt-woman, singer, director and martial artist, who has has written 8 novels and is a regular actress on the PNN web series as the chronically unimpressed Lenore! We chat all about the craft of writing and why she loves mystery so much. Later, you'll be treated to a reading from her haunted house novel, "Tale Half Told"! Check out Killarney's website! And watch her on PNN! ----------------------------------------Retro Ridoctopus is:• Parasite Steve (read)• 8-Bit Alchemy (listen)• Nintenjoe (subscribe)----------------------------------------All original heavy metal music by Enchanted Exile Retro Ridoctopus is part of the Dorkening Podcast Network, the Inebri-Art Podcast Network and is brought to you by Deadly Grounds Coffee!

On this episode of the podcast we catch up with friend of the show Paul Clayton the PNN. Paul took a trip up to West Virginia for the Lucas Oil race at WVMS and visited the Ritchie County Fairgrounds home of the legendary Pennsboro Speedway. Paul talks about his Pennsboro experience, the Lucas Oil Late Model Series race at West Virginia Motor Speedway. The awesome fan support he saw at WVMS, the eventual rain out, we look ahead to the XR Super Series at Kokomo and more on this episode.

Mãe, filha, irmã, namorada, esposa, tia, chefe, colegade trabalho, amiga... As mulheres estabelecem diferentes vínculos e desenvolvem inúmeras habilidades. Estar atento aos detalhes é importante para melhor compreendê-las e respeitá-las. O cuidado com a saúde também deve ser tratado com atenção a cada detalhe. O Saúde Naval convidou duas profissionais para conversar sobre algumas questões que não podem ser deixadas de lado. A CC (Md) Leilane, Encarregada da Clínica de Ginecologia e Obstetrícia do HNNa, e a CT (Md) Manuella Rolim, Encarregada da Clínica de Endocrinologia da PNN, explicam paraque servem os ovários e a tireoide, além dos diversos cuidados, sintomas, fatores de risco e mudanças de hábitos que podem ajudar a prevenir determinadas doenças. Esse bate-papo pode mudar a sua vida. Acesse: www.saudenaval.mar.mil.br/momento-saude-naval e ouça o podcast.

This week on PNN, I will discuss more lies our politicians tell us on a regular basis--from BOTH parties. The first story speaks to lies about the national debt and possible solutions from constitutional scholars. The second story deals with lies sponsored by the gun lobby discussed in context of the latest shooting this past week. The final story deals with the lies told by politicians about our horrible healthcare system. Politicians of both parties refuse to consider Medicare for All, as that would anger their donors--you know--the people who BRIBE them 'legally.' Additionally, the issue of medical debt involves the world of--guess what--PRIVATE EQUITY FIRMS--and yes--I DO have documentation. We will also have our 'Jackass of the Week' award.  Come join us. Jeanine

This week on PNN w/Jeanine Molloff, I will discuss how the Missouri GOP controlled legislature voted to fully defund state libraries. The hypocrisy and cruelty of these policies is obvious. This is truly about unconstitutional state censorship and political retaliation against any dissent. The GOP is determined to foster and maintain a state of collective ignorance by denying any of us the right to read, to question, to think.  The second story deals with a unilateral decision by Mo. Attorney General Andrew Bailey to outlaw and and all gender affirming care for trans people--including consenting adults.  We then have an op-ed on the obituary of Nuremberg prosecutor Benjamin Ferencz--regarding the glaring censorship as corporate media omitted his ongoing criticism of the Iraq war and the Bush administration. I will also have another installment of "My Litte Margie", covering MTG's latest public shows of her immense ignorance, ( and a definite reason WHY abortion should remain accessible and legal). We also have our latest initiate into the Despicable List of Infamy' and the 'Jackass of the Week Award." Come join us. Jeanine

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.09.536164v1?rss=1 Authors: Lev-Ram, V., Palida, S., Deerinck, T. J., Bushong, E. A., Toyoma, B. H., Perez, A., McClatchy, D. B., Prichard, D. R., Savas, J. N., Ellisman, M. H., Yates, J. R., Tsien, R. Y. Abstract: Perineuronal nets (PNN), a specialized form of ECM, surround numerous neurons in the CNS and allow synaptic connectivity through holes in its structure. We hypothesize that PNNs serve as gatekeepers that guard and protect synaptic territory and thus may stabilize an engram circuit. We present high-resolution and 3D EM images of PNN-engulfed neurons showing that synapses occupy the PNN holes and that invasion of other cellular components is rare. PNN constituents are long-lived and can be eroded faster in an enriched environment, while synaptic proteins have a high turnover rate. Preventing PNN erosion using pharmacological inhibition of PNN-modifying proteases or MMP9 knockout mice allowed normal fear memory acquisition but diminished remote-memory stabilization, supporting the above hypothesis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

PNN is experimenting with some parody. This broadcast is a commercial for our upcoming new series, which will begin on Sunday at our regular time. It is named after the Notorious MTG and her penchant for non-stop moronic lies. The opening music to each episode is the music tract from the old television series titled: My Little Margie.  Enjoy! Jeanine

Last week, a Christian elemntary school was attacked by a deranged shooter. Children and adults died, and practically on cue, Tucker Carlson launched a tirade against the trans community. Why? The shooter was a trans woman. Carlson took his gun rights crusade and marched straigth to the convenient conclusion for the GOP of Trump, namely the demand to deny gun rights to minority communities. After all, there's nothing good ol' Tucker Carlson, the ersatz "Prince of tacky t.v. dinners" likes more than to scapegoat minorities, all the while trying to sound like a reasonable person. ;Carlson reasoned that because the shooter was a trans woman, that the entire trans, (even the entire LGBTQ+ community), must be launching a violent crusade against White Christians. Of course, there's not a shred of evidence backing Carlson's moronic claim, but it's FOX after all, and evidence is tossed into the trash. Because of his diatribe, PNN did a deep dive into the history of gun rights vs denial of those rights to minorities and the evidence was damning. In fact, it is not hyperbole to call out Carlson and his supporters as a parallel to the early days of the Third Reich Nazi regime. Hitler himself modeled the disarming of Jews, gays, and other minorities on the earlier unjust laws in the United States.  We will also have our 'Jackass of the Week' award. Come join me.  Jeanine

On this episode of the All Gas No Brakes Podcast we talk to Paul Clayton from Florida. Paul is becoming known on social media as "PNN" for his real time posting about dirt track racing. We talk to Paul about his desire to do that, All-Tech Raceway, Floridaman and more on this episode.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.05.531118v1?rss=1 Authors: Bae, H., Hensch, T. K. Abstract: Neprilysin (Nep) is a membrane-bound zinc-dependent endopeptidase that cleaves a wide variety of small peptides in the body. In the brain, it has gained fame as an important endogenous degrader of amyloid beta peptide, responsible for the pathophysiology of Alzheimer's disease. Nep is expressed specifically by parvalbumin (PV)-expressing inhibitory neurons in the adult cortex, the maturation of which regulates critical period plasticity. Given that PV neuron soma and proximal dendrites are primary sites of perineuronal net (PNN) formation, we investigated the role that Nep plays in PNN and PV neuron maturation and cortical development in the mouse visual cortex, using mice whose Nep expression is constitutively knocked out (Nep KO mice). Nep expression is high in young wildtype mice (P10) and is downregulated rapidly throughout postnatal development. It is especially prominent in layer 5 where it is highly expressed by inhibitory neurons and also expressed at low levels by many excitatory neurons. Contrary to our hypothesis, Nep KO mice did not show an alteration in the relative density or gross morphology of PNNs. Instead, Nep KO mice showed reduced maximal activation of L5 after white matter stimulation and decreased number of inhibitory neurons in L4. These laminar defects may lead to impaired development of optomotor acuity in Nep KO mice. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

O calor aquece o coração e a festa vai começar. Desfiles, blocos, folia. Carnaval é tempo de alegria, mas uma coisa que não pode ser esquecida é a saúde, a sua e a dos outros. No Dia Nacional de Combate às Drogas e ao Alcoolismo, o Momento Saúde Naval recebe a CT (T) Caroline Santos, psicóloga da DHN, e a CT (Md) Marina Rosa, gastroenterologista da PNN. Nesse bate-papo, elas explicam quais as principais consequências físicas e mentais que podem ser causadas pelo uso de drogas e pelo abuso do álcool. Cuide da sua saúde, saiba como tocar neste assunto e ajudar outras pessoas. Acesse sua plataforma de áudio preferida ou www.saudenaval.mar.mil.br/momento-saude-naval e ouça o podcast.

Today's show features a report from PNN, plus comedian Mario "Superstar" Salazar stops by!

This week on PNN, I will discuss the wave of GOP sponsored censorship that is clearly a premeditated systemic attack on the 1st Amendment. Whether its laws that criminalize literature or laws that gag teachers, doctors, etc; the GOP is working feverishly to destroy the 1st Amendment provisions on free speech and free press, unless that speech is consistent with a specific religious and bigoted dogma. So, where are the 1st Amendment heroes? Let's discuss.  We will also have our recurring "Jackass of the Week" award.  Come join me.  Jeanine

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.24.525313v1?rss=1 Authors: Lupori, L., Totaro, V., Cornuti, S., Ciampi, L., Carrara, F., Grilli, E., Viglione, A., Tozzi, F., Putignano, E., Mazziotti, R., Amato, G., Gennaro, C., Tognini, P., Pizzorusso, T. Abstract: Perineuronal nets (PNNs) surround specific neurons in the brain and are involved in various forms of plasticity and clinical conditions. However, our understanding of the PNN role in these phenomena is limited by the lack of highly quantitative maps of PNN distribution and association with specific cell types. Here, we present the first comprehensive atlas of PNN distribution (in Allen Brain Atlas coordinates) and colocalization with parvalbumin (PV) cells for over 600 regions of the adult mouse brain. Data analysis showed that PV expression is a good predictor of PNN aggregation. In the cortex, PNNs are dramatically enriched in layer 4 of all primary sensory areas in correlation with thalamocortical input density, and their distribution mirrors intracortical connectivity patterns. Gene expression analysis identified many PNN correlated genes. Strikingly, PNN anticorrelated transcripts were enriched in synaptic plasticity genes, generalizing PNN role as circuit stability factors. Overall, this atlas offers novel resources for understanding the organizational principles of the brain extracellular matrix. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

The GOP is determined to end Social Security and Medicare/Medicaid using the debt ceiling device as a way to hold the entire US government hostage. Make no mistake, Kevin McCarthy and his cohorts are determined to extract savage cuts to these programs and they are fine with tanking the good faith credit of the US government. Their plan is to cause chaos so, like Grover Norquist, they can drown the US government ..."in a bathtub." So, today's show will explain the debt ceiling and the associated lies the GOP has fed to achieve their singular goal, which is to force the average American to work--until they drop dead. There is a solution and we will discuss that as well.  We will also announce the recipient of PNN's 'Jackass of the Week Award." Come join me.  Jeanine

PNN began in Florida, and it is befitting that it highlight the mockery DeSantis and his GOP trolls have made of the Bill of RIghts. K-12 teachers working with minor children are censored in terms of multiple subjects to the point of lunacy. Now, DeSantis pushes to censor university professors from teaching the TRUTH about systemic racism, misogyny, homophobia, etc. in this nation. These laws are reminiscent of the old Nazi regime of Hitler. Tonight, I will examine the history behind such censorship, and the legal argument against it.  Ron DeSantis is a national disgrace, and the fact that he was reelected in Florida is an even bigger disgrace.  We will also have the 'Jackass of the Week' Award. Come join me.  Jeanine   Come

This week on PNN, I am talking about the GOP defamation wars. The most recent target has been US Congresswoman Katie Porter. A republican colleague, Congressman Ronnie Jackson not only accused Porter of making excuses for pedophiles, but he accused all progressives of the same in a tweet. Jackson is joined by the equally infamous creator of the Libs of TikTok, Chaya Raichik. Keep in mind, neither Ronnie Jackson nor Chaya Raichik have a single shred of evidence to back their defamatory accusations, but they based those accusations on spliced sections of actual congressional testimony being collected by Katie Porter. This incidence is merely the latest incarnation of the GOP War on Truth, using a propaganda machine that routinely slanders, libels and defames. The time is long overdue to start suing these purveyor s of lies. This is our big story.  Our second story deals with the slow pace of criminal prosecutions against the organizers of the Jan. 6th insurrection. Yet another republican, Congressman Ralph Norman, was caught having sent texts to Mark Meadows demanding Trump implement Martial Law. These texts include more members of Congress than was previously reported. This insurrection was also built on a propaganda lie machine  And of coruse, we have our Jackass of the Week Award! Come join me.  Jeanine

This week on PNN, our founder Rick Spisak has another interview with Professor Wendy Lynne Lee of the Commonwealth University of Pennsylvania. Professor Lee has made a special study of the impact right-wing groups have had on politics and academia, delivered with humor and wit.  I will discuss the dishonest judicial scam aka 'originalism.' I will cite the work of noted constitutional scholar and Dean of the UCLA Law School, Erwin Chemerinski as documentation. To put it bluntly, 'originalism' is the tool of choice for conservatives determined to limit human rights to a certain subset, namely "white, Christian, straight males.' There is no other logical outcome if you follow the idea of 'originalism' to its pre-ordained conclusion. While this may sound purely academic, the ramifications of allowing this false theory to continue will result in the complete erosion of human rights for minorities.  And of course, we will have our "Jackass of the Week Award." Come join us.  Jeanine 

Welcome to PNN's Corruption Report! This week, I will discuss why Donald Trump must be criminally prosecuted in order to save the republic. Not only did Trump break multiple federal laws, but set a precedent which will only encourage more illegal behavior from the extremists in the GOP. No president is above the law. Period. Furthermore, Trump has been aided by Judge Aileen Mercedes Cannon as she literally halted the full criminal investigation beng conducted by the DOJ. Trump stealing national security records is far more serious than the Watergate case. Trump placed our national security in dire jeopardy at an incalculable risk. That's story #1. Story #2 deals with the very law which enabled the Flint water crisis, namely the Emergency Manager Act. This 'law' basically places an unnofficial poll tax on lower income munincipalities. It says that if your jurisdiction is deemed "too poor" by the state, your local elections can and WILL be overturned by the state. This law was spearheaded by multiple far right think tanks, including the DeVos funded Mackinac Center. Come join us! Jeanine

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.05.510951v1?rss=1 Authors: Dzyubenko, E., Willig, K. I., Yin, D., Sardari, M., Tokmak, E., Labus, P., Schmermund, B., Hermann, D. M. Abstract: Stroke remains one of leading causes of long-term disability worldwide, and the development of effective restorative therapies is hindered by an incomplete understanding of intrinsic recovery mechanisms in the brain. Here, we explored the involvement of perineuronal nets (PNNs), the facet-like layers of extracellular matrix surrounding fast-spiking interneurons, in brain remodeling and neurological recovery after focal cerebral ischemia in mice with and without induced stroke tolerance. Due to insufficient resolution of conventional microscopy methods, the contribution of ultrastructural changes in PNNs to post stroke brain plasticity remained unknown. Using superresolution stimulated emission depletion (STED) and structured illumination (SR-SIM) microscopy, we revealed that PNN facets become larger and less dense in the post-acute stroke phase. Morphological alterations in PNNs are likely mediated by activated microglia cells, which preferentially enwrap the PNN-coated neurons. The loosening of PNNs is transient and associates with the increased number of GABAergic axonal terminals on inhibitory interneurons in the motor cortical layer 5. The coherent remodeling of PNNs and inhibitory synapses precedes the recovery of motor coordination during the late post-acute stroke phase. In the chronic stroke phase, the initial morphology of PNNs is restored, and the number of GABAergic axonal terminals on motor cortical interneurons is reduced. Our data suggests a novel mechanism of motor cortical plasticity after stroke, and we propose that prolonging PNN loosening during the post-acute period can extend the opening neuroplasticity window into the chronic stroke phase. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.22.509111v1?rss=1 Authors: Lester, E., VanAlstyne, M., McCann, K. L., Reddy, S., Cheng, L., Kuo, J., Pratt, J., Parker, R. Abstract: Tau aggregates are a hallmark of multiple neurodegenerative diseases and can contain RNAs and RNA binding proteins, including SRRM2 and PNN. How these resident nuclear proteins mislocalize and their influence on the prion like propagation of tau fibers remains unknown. We demonstrate that polyserine repeats in SRRM2 and PNN are necessary and sufficient for recruitment to tau aggregates. Moreover, we demonstrate tau fibers preferentially grow in association with endogenous cytoplasmic assemblies, mitotic interchromatin granules and cytoplasmic speckles, which contain SRRM2 and PNN. Polyserine undergoes self assembly in vitro and in cells, where polyserine-assemblies are sites of tau fiber propagation. Modulating the levels of polyserine containing proteins results in a corresponding change in tau aggregation. These findings define a specific protein motif, and cellular condensates, that promote tau fiber propagation. As cytoplasmic speckles form in iPSC neurons under inflammatory or hyperosmolar stress, they may promote tau fiber propagation in various neurodegenerative diseases. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

This week on PNN, I will talk about the passing of Queen Elizabeth, and the mythology surrounding the 'Royals.' Not once during her 70 year reign did she EVER apologize to the many indigenous peoples attacked and colonized by the British Empire. Not once during her 70 year reign did she EVER speak of reparations. The coverage of her passing and the coverage of the younger royals is vapid and dangerous. It is time to tell the truth.  On EJR, I will speak of the campaign to stop Joe Manchin's dirty pipeline deal. I will also speak to the dire warning sent by scientists about the future of life on this planet.  Come join me.  Jeanine

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.07.506934v1?rss=1 Authors: Jetsonen, E., Didio, G., Winkel, F., Llach Pou, M., Boj, C., Kuczynski-Noyau, L., Voikar, V., Guirado, R., Taira, T., Lauri, S. E., Castren, E., Umemori, J. Abstract: Critical period-like plasticity (iPlasticity) can be reinstated in the adult brain by several interventions, including drugs and optogenetic modifications. We have demonstrated that a combination of iPlasticity with optimal training improves behaviors related to neuropsychiatric disorders. In this context, the activation of TrkB, a receptor for BDNF, in Parvalbumin positive (PV+) interneurons has a pivotal role in cortical network changes. However, it is unknown if the activation of TrkB in PV+ interneurons is important for other plasticity-related behaviors, especially for learning and memory. Here, using mice with heterozygous conditional TrkB deletion in PV+ interneurons (PV-TrkB hCKO) in Intellicage and fear erasure paradigms, we show that chronic treatment with fluoxetine, a widely prescribed antidepressant drug that is known to promote the activation of TrkB, enhances behavioral flexibility in spatial and fear memory, largely depending on the expression of the TrkB receptor in PV+ interneurons. In addition, hippocampal long-term potentiation (LTP) was enhanced by chronic treatment with fluoxetine in wild-type mice, but not in PV-TrkB hCKO mice. Transcriptomic analysis of PV+ interneurons after fluoxetine treatment indicated intrinsic changes in synaptic formation and downregulation of enzymes involved in perineuronal net (PNN) formation. Consistently, immunohistochemistry has shown that the fluoxetine treatment alters PV expression and reduces PNNs in PV+ interneurons, and here we show that TrkB expression in PV+ interneurons is required for these effects. Together, our results provide molecular and network mechanisms for the induction of critical period-like plasticity in adulthood. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.31.505900v1?rss=1 Authors: Emery, B. A., Everett, M., Lau, B. Y. B., Krishnan, K. Abstract: Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder is an X-linked neurodevelopmental disorder, where children exhibit motor, speech, cognitive and visual deficits during development as well as early onset of seizures and infantile spasms. CDKL5 disorder results from de novo mutations in CDKL5, which phosphorylates proteins including MECP2, an epigenetic regulator of critical period plasticity. How mutations in CDKL5 gene result in these neurological deficits is unknown. Using a male CDKL5-null mouse model, we systematically characterize the expression of perineuronal nets, which are extracellular matrix structures surrounding parvalbumin+ GABAergic neurons in the primary visual cortex. Perineuronal nets (PNNs) are considered to be barriers to synaptic plasticity, particularly at the end of critical period plasticity in binocular zone. In CDKL5-null male visual cortex, here we report an increase in high-intensity PNN expression in the binocular zone, a decrease in overall PNN expression in the monocular zone, and no differences in PNN expression in rostral V1. These results suggest that at the closure of the visual critical period plasticity, subregion-specific variations in PNN expression lead to functional differences in synaptic plasticity and ultimately, changes in visual function in male CDKL5-null mice. Additionally, the systematic characterization of subregion-specific expression patterns of perineuronal nets lay the groundwork for further studies to probe the roles for perineuronal nets beyond the binocular zone of the mouse primary visual cortex. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

This week on PNN, our founder Rick Spisak crafted an essay that will run. It will be illuminating as always. Next, I will discuss how the conservatives on the SCOTUS (Supreme Court) are once again targeting our rights. This time the case is Moore v. Harper, and the bogus theory pushed by Neil Gorsuch is the Independent States Legislatures Doctrine, which essentially grants state legislatures the power to potentially reverse election results they don't happen to like. This case is a direct attack on democracy itself.  Next, we have our "Jackass of the Week Award.  Come listen.  Jeanine

Today, the Supreme Court handed down a decision in W. Virginia v. EPA, which limits the authority of the EPA to regulate environmental toxins and other forms of pollution. This same 'pro-life' SCOTUS, has handed down a death penalty to the planet. I will discuss the future ramifications of this decision. I will also discuss why Supreme Court justices must be forced to follow a code of ethics. For example, Amy Coney Barrett's father was a corporate attorney for the fossil fuel industry and remains a lobbyist for the same industry. She should have been forced to recuse herself from this case. No such accountability or transparency standard exists for the Supreme Court.  Rick Spisak, our founder, has written a delightful essay for our audience.  And, PNN's Jackass of the Week Award will be granted to a very 'special' recipient.  Come tune in .  Jeanine

The title says it all.  But, check it out and enjoy.  More of Glen H to come in the future.  Politics for a little, to my way of thinking, and then PNN reports for the coming months (starting in November).  Look forward to trivia with Glen at a location mentioned in the podcast (so you have to listen to the podcast).  Enjoy and I think the mics' were good on the ambient noise, you let us know.onemoreandimouttahere@gmail.com - send us your comments, criticism (may care after reading), and suggestions.  Thanks for listening.  Onemoreandimouttahere.com will be up soon. I promise.  

This week on PNN's Sunday Show deals with Florida's own, Senator Rick Scott and his 11 Point Plan to Destroy Medicare, Medicaid, and Social Security. As it turns out, Florida's former governor has a criminal past involving Medicare/Medicaid fraud at a massive scale. Rick Scott was found guilty but never served time. Now, Scott and the GOP want to inflict this new level of blatant criminality on the rest of the nation.  Our Jackass of the Week Award will be announced.  Tune in.  Jeanine

This week on PNN's Sunday Show, I will discuss an undeniable fact, namely that Donald Trump must face criminal prosecution for his role in the January 6th Insurrection. There IS a case to be made, and I will present the case as made by various legal scholars including Harvard Law School Professor, Laurence Tribe. Trump cannot be allowed to walk away from this dangerous coup, mainly because he is planning another one.  And just when you thought the GOP couldn't sink any lower into fascist filth--they do. The National Republican Committee has issued a public statement declaring that the events of January 6th, 2021 were merely an "expression of legitimate political discourse." While the GOP has been criticized for this absurd declaration; no movement has been made to indict and prosecute Donald Trump in a criminal court.  Come join us.  Jeanine

This week on the Sunday edition of PNN, I will discuss the ramification of the two COVID vaccine mandate cases Supreme Court rulings and what they actually mean for the survival of democracy itself. On the surface these cases look rather benign, but the legal 'reasoning' used by unelected conservative judges could destroy the last shred of democracy itself, as the court steals power from the Executive and Legislative branches. Essentially, these two cases serve as the litmus test to destroy any enforcement mechanisms of our regulatory agencies. These are the regulations that help to safeguard our food supply and ensure that the medical people treating you are properly credentialed. These are the regulations that reversed the savage corporate abuses seen in the Sinclair Lewis classic, The Jungle. This is our big story.  Next, I will discuss the mockery of the U.S. Senate as Republicans, aided by two alleged Democrats blocked voting rights, by refusing to amend the rules of the silent filibuster.  Finally, I will present the Jackasserie Award for political treachery and cowardice.  Tune in.  Jeanine

Câncer infantil é um assunto difícil, mas um fato que precisa ser encarado. Como não há prevenção específica, o caminho é ter atenção. Palidez, hematomas ou inchaços, vômito, febre e tosse frequente podem ser fatores que indicam câncer em crianças. Olhar com carinho para os sinais que os pequenos dão é a melhor forma de prevenção. E informar-se também: ouça o podcastsobre o assunto com a CT (Md) Caroline Jarque, pediatra da PNN. Acesse www.saudenaval.mar.mil.br/momento-saude-naval e saiba mais. 23/11 – Dia Nacional de Combate ao Câncer Infantil e 27/11 - Dia Internacional e Nacional de Combate ao Câncer.

This week, I am repeating part of a show that ran this past Sunday on PNN. The show deals with how Spire, one of the largest natural gas suppliers has been causing a panic in St. Louis (where Spire is based), over a 65 mile stretch of pipeline. The STL or St. Louis Pipeline as it has been dubbed had its certificate yanked by a DC court, over claims that the FERC assessment and certification was not in accordance with the actual LAW. The EDF (Environmental Defense Fund) brought the lawsuit against Spire, requesting that FERC do its job in accordance with the Natural Gas Act.  Spire's response was to send thinly veiled threatening emails and using local media as propagandists, claiming that without the 65-mile pipeline--there will be power outages as early as December 13. That is NOT totally true. FERC can extend the temporary permit and will most likely do so. EDF just wants to make sure that Spire isn't allowed to profit from their illegal move. During this investigation, I read from the court document, and found that Spire isolated St. Louis from any other pipelines, rendering us totally dependent on this single pipeline. Spire 'retired' the other pipelines which connected St. Louis to heating gas. EDF is ok with another temporary permit extending through the Winter, as long as Spire doesn't profit from this illegal action.  While investigating this story and making calls to Spire's Public Affairs Director Jason Merrill or it's CEO Suzanne Sitherwood, I must have stepped on some politically powerful toes, because I was 'visited' by 3 detectives from the Intelligence Unit of the St. Louis Metropolitan Police Department. And no--I'M NOT KIDDING.  This was obviously an intimidation tactic. They claimed that Spire filed a complaint against me--FOR MAKING A PHONE CALL.  Come listen.  Jeanine

10 de outubro – Dia Mundial da Saúde Mental Todos temos tarefas com prazos a desempenhar, mas é preciso estar bem de saúde para alcançar os resultados desejados. A CT(S) Mariana Freitas, psicóloga da PNN, explica o que é a síndrome de burnout e dá dicas para você saber como cuidar da sua saúde mental. Ouça o podcast Momento Saúde Naval em: www.saudenaval.mar.mil.br/momento-saude-naval

Brook Hines with Sam Husseini, reporter/activist talks to PNN on biological warfare programs and how the left screwed up the pandemic narrative with a sectarian approach to facts and science. Jeanine Molloff on a new "predictive policing" in Florida schools—Pasco County Sheriff's program that harasses students. CITATIONS Perspectives on the Pandemic video series, excellent Sam Husseini interview with Journeyman Pictures (whole series playlist) Did Covid come from a lab? Maybe not, but it exposes the threat of a biowarfare arms race, by Sam Husseini, Salon, April 24, 2020 Peter Daszak's EcoHealth Alliance Has Hidden Almost $40 Million In Pentagon Funding And Militarized Pandemic Science, by Sam Husseini, Independent Science News Sam Husseini website Some history of biological weapons manufacturing and trade (how we armed Iraq with chemical and biological WMDs), by Norm Dixon, 2004, Counterpunch For more information check in with #DRASTIC on Twitter --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/brook-hines/support

The hunch provided by Diana paid off, whatever was traded off has been making it way across the Belt. And somehow a tabloid station, Pyramid News Network knows about this. The crew of the Sin Claire pursue the relays of PNN, trying to find where they are based and how they know so much dangerous information. Abraxas' Precipice is an actual play of The Expanse Roleplaying Game by Green Ronin Publishing. based on the novels by James S.A. Corey. It airs live on Wednesdays at 6pm PST on twitch.tv/onlyplaywizards Get more Abraxas' Precipice: linktr.ee/abraxasprecipic Abraxas' Precipice GameMaster: John Bultena linktr.ee/onlyplaywizards Abraxas' Precipice players are: Donna Prior (they/them) as Myrtle Cooper linktr.ee/Danicia Michael C. Hsiung (he/him) as Onyx Mundos instagram.com/michaelchsiung Sammy Oh (she/her) as Jackrabbit D'Leon twitter.com/SamTetangco Scott Mitchell (he/him) as Wyatt Thompson instagram.com/smitchell22

Brook Hines with Sam Husseini, reporter/activist talks to PNN on biological warfare programs and how the left screwed up the pandemic narrative with a sectarian approach to facts and science. Jeanine Molloff on a new "predictive policing" in Florida schools—Pasco County Sheriff's program that harasses students. CITATIONS Perspectives on the Pandemic video series, excellent Sam Husseini interview with Journeyman Pictures (whole series playlist) Did Covid come from a lab? Maybe not, but it exposes the threat of a biowarfare arms race, by Sam Husseini, Salon, April 24, 2020 Peter Daszak's EcoHealth Alliance Has Hidden Almost $40 Million In Pentagon Funding And Militarized Pandemic Science, by Sam Husseini, Independent Science News Sam Husseini website Some history of biological weapons manufacturing and trade (how we armed Iraq with chemical and biological WMDs), by Norm Dixon, 2004, Counterpunch For more information check in with #DRASTIC on Twitter --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/brook-hines/support

Allie and Armin discuss the latest news on religion and atheism in the past week