Podcasts about RAC1

This week the 69th edition of the Eurovision Song Contest takes place in Basel, Switzerland. To celebrate, we look back over the history of the competition and explore Catalonia's involvement, from Catalan language entries to the stories of Catalan artists who've graced the Eurovision stage. We interview Jordi Ramos, a journalist for the Catalan radio station, Rac1. He's an expert on Eurovision and the perfect person to explain, through Catalan eyes, what the song contest is all about. Reporter Gigi Giulia catches up with Alfred García, the famous singer from El Prat de Llobregat who represented Spain in Eurovision in 2018, performing the duet Tu Canción with his then-girlfriend Amaia Romero. He reflects on his Eurovision experience and how it marked a turning point in his career.  Plus, reporter Lorcan Doherty analyzes Catalonia's push to become a member of the European Broadcasting Association and compete independently, and host Beth Cohen explores the importance of Eurovision for Catalonia's LGBTQI+ community. This week, our Catalan phrase is “Cantar com els àngels" - “To sing like the angels”, a metaphor used to describe someone who sings exceptionally well, with a voice so beautiful and pure that it seems almost heavenly.

Como sucedió en el pasado episodio con la final de la Copa del Rey, da la impresión de que todos quedaron contentos tras la semifinal de Champions League entre el FC Barcelona y el Inter de Milán, que jugará la final contra el PSG. Artistas invitados (por orden de aparición): Raúl Varela, David Bernabeu, [Cabecera: Jesús Gallego, Javier Herráez, Paco González, Felipe del Campo, Juan Antonio Alcalá, Inma Rodríguez, Paco García Caridad, Julio Maldonado 'Maldini', Antonio Romero, Javier Gómez Matallanas, Alberto Arauz, Roberto Gómez, Manu Carreño, José Joaquín Brotons, José Damián González, José Manuel Monje] Juanma Castaño, Sergio Ramos, Felipe del Campo, Josep Pedrerol, Roberto Gómez, Mati Prats, Siro López, Alexis Martín-Tamayo 'Mister Chip', Paco 'Lobo' Carrasco, Emilio Contreras, Dani Senabre, Manolo Lama, Jota Jordi, Edu García, Rocío Martínez, Zinedine Zidane, Nacho Peña, Juanma Rodríguez, Javi Amaro, José Luis Sánchez, Fernando Evangelio, David Sánchez, Manu Carreño, Antonio Romero, Edu Aguirre, Poli Rincón, Alfredo Duro, Fran Garrido, José Félix Díaz, Hans-Dieter Flick, Sique Rodríguez, Florentino Pérez, Xavi Hernández, Edu Pidal, Rubén Martín, Jesús Gallego, Manolo Oliveros, Josep Maria Minguella, Alfredo Martínez, Raúl Fuentes, Damià López, Lluís Flaquer, Toni Padilla, Quim Domènech, Joan Batllori, Paco González, Dani Garrido, Eduardo Iturralde González, Pável Fernández, Juan Andújar Oliver, Enrique Ortego. [Bonus track: Juanma Castaño, Julio Maldonado 'Maldini', Carlos Martín] Fuentes: Marcador (Radio Marca), Radioestadio (Onda Cero), Carrusel deportivo (Ser), Chiringuito inside, Twitch de Rubén Martín, Tiempo de juego (Cope), Radioestadio noche (Onda Cero), Buenas noches y buenos goles (Radio Marca), La tribu (Radio Marca), El partidazo de Cope, El larguero (Ser), El Barça juga a RAC1. Learn more about your ad choices. Visit megaphone.fm/adchoices

22/04/2025 | Programa del primer EGM de 2025, con récords históricos de esRadio, Catalunya Radio y de RAC1, que por fin consigue llegar a 1 millón. Suben la SER y RNE, y bajan COPE y Onda Cero. En musicales, las mayores subidas para Kiss FM y Los40 Classic, mientras bajan sobre todo Rock FM y Los40 Urban.

Lejos de dar la vuelta a la eliminatoria, el Real Madrid cayó ante el Arsenal en cuartos de final de la Champions League. La reacción blanca sólo existió en boca de algunos periodistas. Artistas invitados (por orden de aparición): Fernando Burgos, Edu Pidal, Alberto Pereiro, Ricardo Sierra, Rocío Martínez, [Cabecera: Jesús Gallego, Javier Herráez, Paco González, Felipe del Campo, Juan Antonio Alcalá, Inma Rodríguez, Paco García Caridad, Julio Maldonado 'Maldini', Antonio Romero, Javier Gómez Matallanas, Alberto Arauz, Roberto Gómez, Manu Carreño, José Joaquín Brotons, José Damián González, José Manuel Monje] Josep Pedrerol, Eduardo Inda, Tomás Roncero, Carme Barceló, José Luis Sánchez, Juanma Rodríguez, Nacho Peña, Edu Aguirre, Manolo Lama, Poli Rincón, Javi Gómez, Eduardo Iturralde González, Antonio Romero, Tomás Guasch, Manolo Sanchís, Pedro Martín, Dani Garrido, Raúl Varela, Pável Fernández, Miguel Quintana, Damiá Lòpez, Juan Andújar Oliver, Edu García, Alexis Martín-Tamayo 'Mister Chip', Manu Carreño, Alfredo Duro, Juanma Castaño, Vicente Boluda, José Antonio Abellán, Cristóbal Soria, Felipe del Campo, Miguel 'Látigo' Serrano, Siro López, Miguel Martín Talavera, Roberto Gómez, Irene Junquera, Diego Plaza, Carlo Ancelotti, Carlos Alcaraz, Ángel García Muñiz, Ricardo Reyes, Jordi Martí, Antonio Sanz, Paul Tenorio, Javier Tintó. [Bonus track: Julio Maldonado 'Maldini', Alfredo Duro, Juanma Castaño]. Fuentes: Marcador (Radio Marca), Radioestadio (Onda Cero), Jugones (La Sexta), Tiempo de juego (Cope), Carrusel deportivo (Ser), RAC1, El partidazo de Cope, Buenas noches y buenos goles (Radio Marca), La tribu (Radio Marca), El larguero (Ser), Radioestadio noche (Onda Cero). Learn more about your ad choices. Visit megaphone.fm/adchoices

El Arsenal ha dejado al borde de la eliminación al campeón de Europa. Entre tímidos tambores de remontada, arrecian las críticas contra las estrellas del equipo y, por supuesto, contra Carlo Ancelotti. Artistas invitados (por orden de aparición): Manu Carreño, Axel Torres, Antón Meana, Bruno Alemany, Antonio Romero, Jesús Gallego, [Cabecera: Jesús Gallego, Javier Herráez, Paco González, Felipe del Campo, Juan Antonio Alcalá, Inma Rodríguez, Paco García Caridad, Julio Maldonado 'Maldini', Antonio Romero, Javier Gómez Matallanas, Alberto Arauz, Roberto Gómez, Manu Carreño, José Joaquín Brotons, José Damián González, José Manuel Monje] Rocío Martínez, Miguel 'Látigo' Serrano, Javi Amaro, Felipe del Campo, Roberto Gómez, Fernando Burgos, Miguel Venegas, Alberto Pereiro, Enrique Ortego, Damià López, Xavi Hernández, Elías Israel, Javier Tintó, Raúl Varela, Jota Jordi, José Luis Sánchez, Josep Pedrerol, Tomás Roncero, Miguel Quintana, Adrián Blanco, José Manuel Monje, Edu Aguirre, José María García, Juanma Rodríguez, Roberto Palomar, Edu Pidal, Siro López, Miguel Ángel Toribio, Nacho Peña, Manolo Lama, Paco García Caridad, Carme Barceló, Florentino Pérez, Juanma Castaño, Enrique Marqués, Pedro Riesco, David Sánchez, Paco González, Matías Prats, Raúl Asencio, Jaime Rodríguez, Antonio Sanz. [Bonus track: Rafael Sahuquillo, Hans-Dieter Flick] Fuentes: Radioestadio (Onda Cero), RAC1, El partidazo de Cope, El desmarque (Cuatro), Buenas noches y buenos goles (Radio Marca), El larguero (Ser), Radioestadio noche (Onda Cero), La tribu (Radio Marca), El chiringuito de jugones (Mega). Learn more about your ad choices. Visit megaphone.fm/adchoices

En el marc del 25è aniversari dels Estudis de Ciències de la Informació i de la Comunicació UOC parlem amb Laura Aznar, sociòloga i periodista a Crític. Presentadora i directora d'El Pòdcast de Crític, col·laboradora en diversos mitjans de comunicació com TV3, RTVE i RAC1 i professora col·laboradora al Màster de Periodisme i Comunicació Digital de la UOC. Amb ella vam parlar del sorgiment de mitjans alternatius com Crític, La Directa, La Marea, El Salto, CTXT, etc. al voltant del 15M; del periodisme fet a foc lent; del que suposa ser dona en un sector que segueix molt masculinitzat; del mansplaining i de la dificultat de fer-se un lloc i ser esquerda en espais hostils com les tertúlies de ràdio i televisió; de desinformació i l'auge de la ultradreta; i, per descomptat, del futur de la professió.

Els embassaments ja vessen, però l'Angelines vol tenir un record per al Príncipe Carlos. Cospedal diu que els àudios de RAC1 són “editats”: en Jean Paul ens avisa dels perilla de la IA. La Unió Europea vol que ens preparem per a la guerra: hi truquem i ens atén Zoraida.

Con Eduardo Madina, Joan Subirats y Elisa de la Nuez. Altos funcionarios de la Administración Trump añadieron por error a Jeffrey Goldberg, director de The Atlantic, a un grupo de mensajería en Signal destinado a coordinar ataques militares contra objetivos hutíes en Yemen. Este error expuso información altamente sensible sobre operaciones militares inminentes. Así que Feijoo compra abiertamente la fórmula presupuestaria valenciana y ese aval envalentona a Vox que insiste en que sus condiciones están claras. Todo el que quiera unas cuentas con el sello de la ultraderecha debe asumir con ellas su agenda política como ha hecho el PP en Valencia. La exsecretaria del PP, María Dolores de Cospedal, ha negado la veracidad de los audios adelantado por Rac1 con Villarejo donde se jactan de haber cambiado la historia en Cataluña.

Con Eduardo Madina, Joan Subirats y Elisa de la Nuez. Altos funcionarios de la Administración Trump añadieron por error a Jeffrey Goldberg, director de The Atlantic, a un grupo de mensajería en Signal destinado a coordinar ataques militares contra objetivos hutíes en Yemen. Este error expuso información altamente sensible sobre operaciones militares inminentes. Así que Feijoo compra abiertamente la fórmula presupuestaria valenciana y ese aval envalentona a Vox que insiste en que sus condiciones están claras. Todo el que quiera unas cuentas con el sello de la ultraderecha debe asumir con ellas su agenda política como ha hecho el PP en Valencia. La exsecretaria del PP, María Dolores de Cospedal, ha negado la veracidad de los audios adelantado por Rac1 con Villarejo donde se jactan de haber cambiado la historia en Cataluña.

En parlem amb Carme Brit, psicòloga, coach i formadora i escoltem què passa a RAc1, amb l'enquesta de Guillem Estadella

Aunque la eliminatoria de octavos de final de Champions League entre Real Madrid y Atlético duró 210 minutos, el lanzamiento anulado al delantero del Atlético de Madrid en la tanda decisiva ha pasado ya a la historia de los derbis, del fútbol español y del fútbol europeo. Artistas invitados (por orden de aparición): Josep Pedrerol, José Luis Sánchez, Edu Aguirre, Álex Silvestre, Alfredo Duro, Belén Sánchez, Iñaki Villalón, [Cabecera: Jesús Gallego, Javier Herráez, Paco González, Felipe del Campo, Juan Antonio Alcalá, Inma Rodríguez, Paco García Caridad, Julio Maldonado ‘Maldini', Antonio Romero, Javier Gómez Matallanas, Alberto Arauz, Roberto Gómez, Manu Carreño, José Joaquín Brotons, José Damián González, José Manuel Monje] Raúl Varela, Ainhoa Sánchez, Paco González, Hugo Condés, Manolo Lama, Javi Balboa, Jorge D'Alessandro, José Antonio Martín Otín ‘Petón', Manolo Sanchís, Gonzalo Miró, Fernando Burgos, Carlos Martínez, Damià López, Antonio Ruiz, Miguel Martín Talavera, Antonio Romero, Miguel Ángel Toribio, Alexis Martín-Tamayo ‘Mister Chip', Miguel Quintana, Álvaro Benito, Miguel Ángel Díaz ‘Miguelito', Poli Rincón, Toño Mateu Lahoz, Eduardo Iturralde González, Pedro Martín, Juan Andújar Oliver, Pável Fernández, Felipe del Campo, Tomás Roncero, Alfredo Relaño, Edu García, Dani Garrido, Pablo Pinto, Paco Buyo, Miguel Ángel Méndez, Juanma Castaño, José Rodríguez, Diego Pablo Simeone, Siro López, Santiago Cañizares, Juan José Anaut, Rafael Sahuquillo, Enrique Marqués, Emilio Contreras, Paul Tenorio, Roberto Morales, Javier Milei, José Damián González, Isaac Fouto, Roberto Gómez, Roberto Palomar, José Manuel Monje, Miguel ‘Látigo' Serrano, Santiago Segurola, Antonio Sanz, Mati Prats, Rubén Uría, Xavier Estrada Fernández, Nacho Peña, Alberto García. [Bonus track: José María García, José Ramón de la Morena] Fuentes: El partidazo de Cope, Radioestadio noche (Onda Cero), Buenas noches y buenos goles (Radio Marca), La tribu (Radio Marca), El larguero (Ser), El chiringuito de jugones (Mega), El desmarque (Cuatro), RAC1, Movistar+ Liga de Campeones, Chiringuito Inside. Learn more about your ad choices. Visit megaphone.fm/adchoices

Tras la victoria del Real Madrid en el Etihad Stadium, gran parte de la prensa española subrayó la mediocridad de su rival, el Manchester City. Artistas invitados (por orden de aparición): Juanma Castaño, Paco González, Manolo Lama, Siro López, Isaac Fouto, [Cabecera: Jesús Gallego, Javier Herráez, Paco González, Felipe del Campo, Juan Antonio Alcalá, Inma Rodríguez, Paco García Caridad, Julio Maldonado 'Maldini', Antonio Romero, Javier Gómez Matallanas, Alberto Arauz, Roberto Gómez, Manu Carreño, José Joaquín Brotons, José Damián González, José Manuel Monje] Javi Amaro, Javier Tintó, Josep Pedrerol, Roberto Gómez, Amalio Moratalla, Enrique Ortego, Jesús Gallego, Enrique Marqués, Felipe del Campo, David Bernabeu, Nacho Peña, Miguel 'Látigo' Serrano, Dani Senabre, Rubén Martín, Edu Aguirre, Roberto Palomar, Manu Carreño, Tomás Roncero, Pedja Mijatovic, Mati Prats, Manu de Juan, Pep Guardiola, Alberto Pereiro, Antonio Romero, Juanma Rodríguez, José Luis Sánchez, Jota Jordi, Ana Garcés, Paco Buyo, Fran Garrido, José Bordalás, Alfredo Duro, Julio Pulido, David Barral, Dani Garrido, David Sánchez, Antón Meana, Bruno Alemany, Damià López. [Bonus track: Alberto Pereiro, Alexis Martín-Tamayo 'Mister Chip', Juan Andújar Oliver, Edu García, Fernando Burgos] Fuentes: El larguero (Cadena Ser), Radioestadio noche (Onda Cero), El primer palo (Es Radio), Buenas noches y buenos goles (Radio Marca), A diario (Radio Marca), El partidazo de Cope, El desmarque (Cuatro), RAC1. Learn more about your ad choices. Visit megaphone.fm/adchoices

Bruno Oro compta amb una experiència de més de 20 anys de carrera, entre la seva trajectòria podem veure que va començar a la ràdio, concretament al programa 'Minoria absoluta' de RAC1 l'any 2000, programa que va ser guardonat amb un Premi Ondas. Anys més tard va aterrar a altres emisores i va fer el salt a les pantalles de televisió passant per diverses cadenes, fins a arribar als programes 'Polònia' i 'Crackòvia' de TV3, on va tornar a guanyar un Ondas. Bruno Oro connecta el seu Llapis de Memòria.

En parlem amb el periodista i cronista parlamentari Josep Maria Martí Rigau i també amb Laia Colomé, l'enviada especial de RAC1  

La periodista y humorista denuncia públicamente los abusos de su exjefe Quim Morales, generando una ola de testimonios en el ámbito del periodismo catalán

Santi Giménez, nascut a Barcelona, es dedica al periodisme esportiu i actualment és el subdirector del diari AS de Catalunya, però ha treballat i col·laborat a altres mitjans de comunicació com ara la Cadena SER, RAC1, TV3, entre altres. Connectem el Llapis de Memòria de Santi Giménez.

La redacció de RAC1 és un pis d'estudiants

Leo Bachanian y Manuel Sánchez aprovechan que a la mesa de Universo Premier League se suma Miquel Agut, periodista de la emisora catalana RAC1, para analizar la presentación del equipo de Arne Slot ante el Girona por la jornada 6 de la Champions League. Como siempre, la mirada puesta en cómo les fue a los equipos de la Premier en Champions: los Reds líderes de todo, el Manchester City y una caída más, Emery y su laberinto de ataque (Watkins o Durán) y un Arsenal que da paso a la próxima generación de talentos hechos en casa como Myles Lewis-Skelly. Además, la previa del Derby de Manchester. Y a tí, si te gusta Universo Premier League, suscríbete al programa. Arrancamos! Hosted on Acast. See acast.com/privacy for more information.

Leo Bachanian y Manuel Sánchez aprovechan que a la mesa de Universo Premier League se suma Miquel Agut, periodista de la emisora catalana RAC1, para analizar la presentación del equipo de Arne Slot ante el Girona por la jornada 6 de la Champions League. Como siempre, la mirada puesta en cómo les fue a los equipos de la Premier en Champions: los Reds líderes de todo, el Manchester City y una caída más, Emery y su laberinto de ataque (Watkins o Durán) y un Arsenal que da paso a la próxima generación de talentos hechos en casa como Myles Lewis-Skelly. Además, la previa del Derby de Manchester. Y a tí, si te gusta Universo Premier League, suscríbete al programa. Arrancamos! Hosted on Acast. See acast.com/privacy for more information.

"El Mat

És la presó que s'ha convertit en l'"escorxador humà" de Bashar-al Assad, amb Helena Pelicano, la corresponsal de RAC1  

El pòdcast de salut i nutrició Respostes que alimenten va estrenar-se a la plataforma RAC+1 el 3 de març del 2021. La metgessa nutricionista Magda Carlas i la periodista Esther Muñoz fa gairebé quatre anys que ajuden l'audiència a millorar els hàbits alimentaris, resolent preguntes habituals en aquest àmbit. I per celebrar aquest "centenari" han volgut esbrinar quins són els dubtes sobre alimentació que tenen els editors de RAC1 i RAC105. Voleu saber què els preocupa sobre l'alimentació a Toni Clapés, Jordi Basté, Ernest Codina, Noemí Polls, Xavi Bundó i a la mateixa Esther Muñoz? Aquí teniu la segona i última part d'aquesta celebració dels 100 capítols. 

En parlem amb Benet Íñigo, cap de societat de RAC1

El pòdcast de salut i nutrició Respostes que alimenten va estrenar-se a la plataforma RAC+1 el 3 de març del 2021. La metgessa nutricionista Magda Carlas i la periodista Esther Muñoz fa gairebé quatre anys que ajuden l'audiència a millorar els hàbits alimentaris, resolent preguntes habituals en aquest àmbit. I per celebrar aquest "centenari" han volgut esbrinar quins són els dubtes sobre alimentació que tenen els editors de RAC1 i RAC105. Voleu saber què els preocupa sobre l'alimentació a Marc Giró, Òscar Dalmau, Òscar Andreu, Núria Travesa, Joan Maria Pou o Anna Vallhonesta? Aquí teniu la primera part d'aquesta celebració dels 100 capítols. 

Manu Planetario, Dani Egea y Sergio Jimón charlan con Jordi Colomer, periodista especializado en baloncesto de Rac1 y Catalunya Ràdio. Además nuestro Opinodeque con equipos y jugadores que nos han llamado la atención esta primera semana, el estreno de la sección "La vuelta al cole" repasando diferentes normas de la liga (hoy los Bird Rights) y el nuevo test de Dani Egea que casi acaba en un retrovisor... O en un programa de prensa rosa.

Amb Jaume Borja als “Teloners del ‘Versió RAC1'” ha explicat com va conèixer la seva dona

Avui ens visita la veu del Barça a RAC1, Joan Maria Pou. Les seves narracions en dies històrics com Stamford Bridge ens queden a la memòria. Avui, no obstant li treurem tot el que porta dins, de futbol i el que no és futbol.

PRISA se lleva el 65% de la publicidad institucional de la radio española. Nada menos que el 65% de la publicidad institucional de la radio española, apunta Javier Cárdenas, es la que se lleva en grupo Prisa. Si eres deprisa, no importa la audiencia, te llevas la parte grande del pastel de la radio. Hablamos de 16 millones de euros de subvención al año, entre la ser, los 40, dial, ya sabes, hay un montón. Por cierto, nuestra antigua casa Europa FM, más de medio millón, también. Pero claro, hay que incluirla en A3 Media. Medio millón que le van soltando, porque no podía estar soltándole 16 millones de euros continuamente, como le soltaron un mes después de que nos echaran. Al mes le dieron a mi ex emisora ​​de radio, al mes de echarnos, mucho más dinero que a todas las emisoras del grupo Prisa, que son muchas más. A3 Media, ya que estamos hablando de ese grupo, en total Antena 3, por ejemplo, es la televisión que más recibe del gobierno, un poco más que Telecinco, estamos en casi 13 millones de euros al año, o sea, más de un millón al mes de sus impuestos van a Antena 3. En total, A3 Media, 25 millones de ayuda, de subvención, Mediaset 24, después de Antena 3 y Telecinco, está la sexta y cuatro, como cadenas que más reciben. RAC1, por cierto, si sumas la vanguardia, RAC1, etcétera, la cosa se va a más de 3 millones y medio solo del gobierno central, luego la Generalitat de Cataluña. Hablamos de darle más de 3 millones de euros a un grupo que lleva los últimos 8 años trabajando por y para la fractura de España.Para la independencia. ¿os dais cuenta qué grado de locura? .En total, el reparto es de 190 millones de 17 ministerios. Hacen 7.000 pagos cada año de dinero a varios medios. En prensa, que nos hemos dejado prensa, ABC reciben unos pocos cientos de miles más que El Mundo, que es el número 2. El Mundo se lleva más que el país. El más leído por la gente de derechas, es yo te doy esta cantidad de dinero si ahora comienzas a cambiar la tendencia.

Bon dia, com anem? Espero que estiguis molt bé! Avui et vull parlar d'una entrevista escrita que em van fer a RAC1. La pots llegir aquí: https://www.rac1.cat/societat/20240618/178516/jove-catalana-parla-vuit-idiomes-sap-greu-oblidar-paraules-catala.html Espero que sigui interessant! Com em pots ajudar? Subscriu-te al meu canal de YouTube aquí. Hi trobaràs, entre altres coses, una llista de reproducció amb més de 60 vídeos per aprendre català, sempre amb l'opció d'activar els subtítols en català o en anglès (enllaç aquí). Per donar-me altres idees pel podcast, també em pots deixar un missatge aquí. Per comprar-me un cafè a Ko-Fi i ajudar-me a continuar amb aquest projecte, ves aquí. Si em vols ajudar, pots compartir el meu contingut o donar-me suport a Patreon. A Patreon també hi trobaràs 100 transcripcions del podcast. També em pots escriure un missatge a l'instagram. Moltes gràcies a l'Oskar per la música de fons (https://www.studionystrom.se) Espero que sigui interessant! Fins aviat, que vagi bé! Laura

Pugen les temperatures i en parlem amb l'entrenadora del temps de RAC1, la Mònica Usart. Comença la selectivitat: Conrad Consum exigeix que el deixin en pau. L'Angelines, en contra del control parental dels mòbils dels adolescents. 

El Real Madrid conquistó en Wembley un nuevo título en la Champions League. Así vivieron las radios la final contra el Borussia Dortmund.Artistas invitados: Javi Lázaro, Javi Amaro, [Cabecera: Javier Herráez, Paco González, Juan Antonio Alcalá, Inma Rodríguez, Paco García Caridad, Julio Maldonado 'Maldini', Felipe del Campo, Javier Gómez Matallanas, Alberto Arauz, Roberto Gómez, Manu Carreño, José Joaquín Brotons, José Damián González, José Manuel Monje] Dani Garrido, Gonzalo Palafox, Alexis-Martín Tamayo 'Mister Chip', Paco González, Santiago Cañizares, Poli Rincón, Raúl Varela, Manolo Lama, Antonio Romero, Fernando Burgos, Alberto Pereiro, Alfredo Relaño, Miguel 'Látigo' Serrano, Felipe del Campo, Tomás Guasch, Miguel Ángel Toribio, Tomás Roncero, Edu García, Miguel Ángel Díaz 'Miguelito', Alberto Edjogo, Adrián Blanco, Damià López, Enrique Ortego, Manolo Sanchis, Pedro Martín, Arancha Rodríguez.Fuentes: Marcador (Radio Marca), Tiempo de juego (Cope), Carrusel deportivo (SER), Radioestadio (Onda Cero), RAC1. Hosted on Acast. See acast.com/privacy for more information.

Analitzem l'entrevista de Míchel a 'El Món a RAC1' després de que el Girona s'hagi classificat matemàticament per la Champions, i parlem també del partit entre els gironins i el Barça, i de la situació actual dels blaugranes.

Eliminado de la Champions un martes y a once puntos del líder al siguiente domingo, el equipo azulgrana se resigna a cerrar la temporada sin títulos y con Xavi al frente un año más, al contrario de lo que anunció en enero.Artistas invitados: Miguel Rico, Isaac Fouto, Mónica Marchante, [Cabecera: Javier Herráez, Paco González, Juan Antonio Alcalá, Inma Rodríguez, Paco García Caridad, Julio Maldonado 'Maldini', Felipe del Campo, Javier Gómez Matallanas, Alberto Arauz, Roberto Gómez, Manu Carreño, José Joaquín Brotons, José Damián González, José Manuel Monje] Tomás Roncero, José María Aznar, Helena Condis, David Bernabeu, Toni Freixa, Albert Lesan, Jota Jordi, Josep Pedrerol, Nacho Peña, Paco 'Lobo' Carrasco, Xavi Martín, Edu Aguirre, Juanma Rodríguez, Xavi Hernández, Juanma Castaño, Fernando Evangelio, Víctor Lozano, Lluís Flaquer, Manu Carreño, Paco García Caridad, Edu Pidal, Josep Capel, Pablo Pinto, José Mourinho, Sique Rodríguez, Paco González, Siro López, Damiá López, Emilio Pérez de Rozas, Alfredo Martínez, Paul Tenorio, Carlos Pozuelo, Roberto Palomar, Antonio Romero, Julio Pulido, Rocío Martínez, Santiago Segurola, Raúl Varela, Amalio Moratalla, Bruno Alemany, Cristina Cubero, Carles Fité, Jesús Gallego. [Bonus track: Rafael Sahuquillo, Jamal Musiala]Fuentes: Tiempo de juego (Cope), El golazo de Gol, Rondeando (8TV), Solo para culés, A diario (Radio Marca), Radioestadio noche (Onda Cero), Carrusel deportivo (Cadena Ser), La posesión (Sport TV), El partidazo de Cope, El Barça juga a RAC1, El larguero (Cadena Ser). Hosted on Acast. See acast.com/privacy for more information.

El polémico final del Valencia-Real Madrid y el gol de Jude Bellingham fuera de tiempo nos devuelve, una semana más, a las disputas arbitrales, con el mar de fondo del 'Caso Negreira'.Artistas invitados: Miguel 'Látigo' Serrano, Edu García, [Cabecera: Javier Herráez, Paco González, Juan Antonio Alcalá, Inma Rodríguez, Paco García Caridad, Julio Maldonado 'Maldini', Felipe del Campo, Javier Gómez Matallanas, Alberto Arauz, Roberto Gómez, Manu Carreño, José Joaquín Brotons, José Damián González, José Manuel Monje] Manu Carreño, Albert Luque, Antonio García Ferreras, Josep Pedrerol, Antonio Romero, Paul Tenorio, José Luis Corrochano, José Luis Sánchez, Edu Aguirre, Siro López, Xavi Hernández, Paco González, Zinedine Zidane, Carlos Martínez, Alberto Pereiro, Raúl Varela, Juanma Rodríguez, Alfredo Duro, Manolo Lama, Hugo Ballester, Tomás Roncero, Pablo López, Miguel Ángel Toribio, Bernd Schuster, Ricardo Sierra, Fernando Burgos, Poli Rincón, Damià López, Alexis Martín-Tamayo 'Mister Chip', Dani Garrido, José Antonio Ponseti, Fernando Morientes, Alfonso Pérez Burrull, Edu García, Cayetano Ros, Antón Meana, Javi Lázaro, Javi Balboa, Hugo Duro, Eduardo Iturralde González, Juan Andújar Oliver, Hugo Condés, David Bernabeu, Isaac Fouto, Roberto Palomar, Gonzalo Miró, Santiago Cañizares, Juanma Castaño, Antonio Sanz, Jorge Liaño, Mónica Marchante. [Bonus track: Miguel 'Látigo' Serrano, Raúl Varela, José Luis Pascual, Paco Navarro]Fuentes: Marcador (Radio Marca), Radioestadio (Onda Cero), Carrusel deportivo (Cadena Ser), Tiempo de juego (Cope), A diario (Radio Marca), El chiringuito de jugones (Mega), Movistar+ LaLiga, RAC1, Al rojo vivo (La Sexta), Sport. Hosted on Acast. See acast.com/privacy for more information.

El Barça continua paint l'adeu de Xavi a final de temporada i a poc a poc anem coneixent més detalls dels motius que l'han portat a prendre aquesta decisió. Pel que sabem a RAC1, Xavi va prendre la decisió de marxar abans de Nadal. Parlem de la crisi del Barça i ens preguntem si l'adeu de Xavi serà bo o dolent pel club.

El Girona tanca una primera volta històrica després de guanyar l'Atlètic de Madrid al temps de descompte i arriba a l'equador de la Lliga com a campió d'hivern empatat a punts amb el Reial Madrid. L'equip de Míchel va imposar-se 4 a 3 amb gols de Valery, Savinho, Blind i Iván Martín. Madrid i Girona han aconseguit 48 punts dels 57 possibles. Això són 10 més que Atlètic de Madrid i Barça. Els blaugrana juguen avui a dos quarts de 10 al camp de Las Palmas, en directe des d'una hora abans a RAC1.

El Reial Madrid va golejar 4 a 1 el Vila-real i torna a ser el líder provisional de Primera. Ara bé, avui el Girona, amb un punt menys, pot tornar a avançar-lo si guanya l'Alabès a Montilivi, a les 9 del vespre i en directe a RAC1. En canvi, el Barça es despenja cada vegada més. Dissabte va empatar a un al camp del València i ara és tercer. Té el Madrid a set punts i el Girona podria escapar-se-li a 9.

El Reial Madrid és líder provisional en espera del que faci avui el Girona contra l'Athletic de Bilbao a Montilivi a les nou i en directe a RAC1. Ahir els blancs van guanyar 0 a 3 el Cadis amb dos gols de Rodrygo i un de Bellingham. Ara el Madrid té 35 punts, un més que el Girona i quatre més que l'Atlètic de Madrid, tots dos amb un partit menys. El Barça és quart, a quatre punts del lideratge.

Puigdemont es clavadito a Sánchez. También quiere más escoltas. Otro parecido entre Puigdemont y Sánchez , es lo Javier Cárdenas te explica en su programa.En las últimas horas, el equipo del ex president pidió por escrito a la Generalitat protección de los Mossos, pero Pere Aragonés, tal como ha avanzó OKDIARIO, se negó a concedérsela. Los Mossos d'Esquadra no tienen competencias para actuar fuera del territorio español y para poder prestar un servicio de escoltas en Bélgica requieren de la autorización del Ministerio de Interior que, hasta ahora, siempre la ha rechazado.Ha sido el ministro de la Presidencia, Relaciones con las Cortes y Memoria Democrática en funciones, Félix Bolaños, el que ha asegurado en una entrevista en RAC1 que el Ministerio del Interior «tramitará y seguro que resolverá lo que proceda» sobre la petición de escolta por parte de Carles Puigdemont.Tras años negando la protección, al argumentar que no había riesgo para su integridad física y que estaba fugado de la Justicia fuera de España, Bolaños asegura ahora que «nadie cuestiona la seguridad de las personas y por muchas diferencias ideológicas que pueda haber». La cuestión llegó a provocar la investigación a varios agentes de los Mossos y la condena a un ex consejero y un sargento.Este lunes, el jefe de la oficina del ex presidente de la Generalitat Carles Puigdemont, Josep Lluís Alay, investigado en la causa del Tsunami, pidió por carta al conseller de Interior de la Generalitat, Joan Ignasi Elena, la «asignación inmediata y con carácter de urgencia» de los efectivos de escolta de los Mossos d'Esquadra al ex president.El tema de la escolta de Puigdemont siempre ha sido una cuestión polémica desde su marcha a Bruselas para no tener que responder ante los tribunales españoles tras la declaración de independencia. El ex conseller de Interior de Quim Torra, Miquel Buch, decidió contratar como asesor a Lluís Miquel Escolà, el sargento que acompañó a Puigdemont en su huida, para que dedicase su jornada laboral a sueldo del Govern a proteger al ex president.Buch, que también se beneficiará de la amnistía, fue condenado a cuatro años y medio de prisión y 20 de inhabilitación por cometer un delito de prevaricación y otro de malversación. Escolà, por su parte, fue condenado a cuatro años de cárcel y 19 de inhabilitación.

Arriba l'entretemps i connectem amb una de les millors meteoròlogues de RAC1: la Mònica Usart. Connectem amb en Jordi Armenteras i l'Arnau Mañé perquè ens expliquin les peripècies del MHP a Madrid. Conrad Consum obre el seu Consumtori, edició especial setmana laboral de 4 dies.

Parlem de la cursa de RAC1 amb Aleix Parisé, Mònica Usart i Sergi Ambudio; i del Porto – Barça de la Lliga de Campions amb Joan Maria Pou i Gemma Soler.

Hola, com va tot? Avui parlem d'una cosa molt especial que m'ha passat: m'han entrevistat a Rac1, al programa "Via Lliure". En aquest episodi us ho explico i us en deixo un fragment. Vaig demanar permís i em van dir que podia fer servir l'àudio. En aquest enllaç hi podeu trobar l'àudio complet: https://www.rac1.cat/via-lliure/20230827/112711/lingueistes-catalanes-triomfen-mes-xarxes.html Com em pots ajudar? Subscriu-te al meu canal de YouTube aquí. Hi trobaràs, entre altres coses, una llista de reproducció amb més de 60 vídeos per aprendre català, sempre amb l'opció d'activar els subtítols en català o en anglès (enllaç aquí). Per donar-me altres idees pel podcast, també em pots deixar un missatge aquí. Per comprar-me un cafè a Ko-Fi i ajudar-me a continuar amb aquest projecte, ves aquí. Si em vols ajudar, pots compartir el meu contingut o donar-me suport a Patreon. Una novetat important! A Patreon també hi trobaràs transcripcions del podcast. També em pots escriure un missatge a l'instagram. Moltes gràcies a l'Oskar per la música de fons (https://www.studionystrom.se) Espero que sigui interessant! Fins aviat, que vagi bé! Laura

Fem tertúlia esportiva de la prèvia d'inici de lliga amb l'editor del 'Barça juga a RAC1', Joan Maria Pou, el narrador de l''Espanyol juga a RAC1', Edu de Batlle i en Miquel Agut, narrador del 'Girona juga a RAC1'.

Dr Glenn McConell chats with Dr Carlos Henríquez-Olguín from The University of Copenhagen, Denmark. Carlos is an up and coming rising star exercise metabolism researcher. He discusses the challenges of doing mechanistic exercise research in Chile and how he ended up moving to the University of Copenhagen. Language challenges etc. He has been doing really ground breaking research on reactive oxygen species (ROS) and contraction/exercise and already won awards for his research. Twitter: @MuscleBiology.0:00. Introduction/reason invited Carlos onto Inside exercise4:00. Challenges doing mechanistic exercise research in Chile etc9:37. Cell culture and mouse ROS experiments in Chile12:11. How got into reactive oxygen species research14:25. Muscle dystrophy, contraction and ROS16:09. Chronic versus acute increases in ROS16:49. How/why moved to the University of Copenhagen19:20. No success with initial research at the University of Copenhagen20:30. Made his own luck21:39. The need for patience from supervisor if facing challenges23:40. Language challenges when coming from Chile26:30. Giving better visibility to early career researchers31:04. Prizes he has won in both exercise and ROS34:08. Challenges publishing when from less scientifically recognized countries36:22. What are reactive oxygen species?37:50. Theory of ROS and aging38:30. ROS, antioxidants, oxidative stress, ROS signaling40:05. Muscle antioxidants, exercise and disease42:19. Where in muscle are ROS coming from during contraction?45:02. NOX2, RAC1, glucose uptake with contraction47:21. What's activating ROS production during contraction?48:11. Nitric oxide vs ROS vs both?50:15. Acute versus chronic increases in ROS53:16. Best exercise for increasing your antioxidant defenses?57:50. High ROS production from mitochondria in some diseases59:30. Can exercise improve these diseases by producing ROS?1:00:41. Compartmentalization of ROS production in muscle1:02:03. Should supplement with antioxidants?1:07:23. Increased mortality in people taking high levels of supplements1:06:32. Antioxidant supplements improve those with chronically high ROS?1:09:20. Mitochondria ROS and mitochondria specific antioxidants1:14:37. Exercise and antioxidant gene expression1:16:50. Mitochondria have antioxidant enzymes1:17:50. Carlos's methods to study ROS with contraction/insulin resistance1:23:20. Takeaway messages1:27:39. ROS and glucose uptake during exercise1:29:43. Outro (9 seconds) Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise's effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: glenn.mcconell@gmail.comSubscribe to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice

Avui arrenquen la pretemporada Barça, Girona i Madrid, just quan els blaugrana esperen fer oficial el fitxatge de Vítor Roque. Fonts properes a la negociació han explicat a RAC1 que l'acord entre les parts és total. Això el dia que les portades dels diaris esportius homenatgen Luis Suárez, mort ahir als 88 anys. Era l'únic futbolista espanyol home que havia guanyat la pilota d'Or. 

La Competència | En Jep, preparat per fer la transició lògica “tertulià de Rac1” -> “candidat d'algun partit”. Manuel Valls es postula per desembussar Barcelona. Comença el Sónar i en parlem amb un històric del festival: Juli Pijuli. Mossèn Papiol proposa el seu propi festival.

L'Angelines trenca Rac1. Villarejo és a tot arreu. La sèrie de Corinna és la nova obsessió de l'Angelines.

Aunque algún periodista vaticinaba ya «un nuevo fracaso del Real Madrid», los blancos se clasificaron para la final de la Copa del Rey con una goleada en campo del FC Barcelona.Artistas invitados: Tomás Roncero, Josep Pedrerol, [Cabecera: Javier Herráez, Josep Pedrerol, Tomás Roncero, Juan Antonio Alcalá, Paco García Caridad, Julio Maldonado 'Maldini', Paco González, Felipe del Campo, Javier Gómez Matallanas, Alberto Arauz, Roberto Gómez, Manu Carreño, José Joaquín Brotons, José Damián González, José Manuel Monje] Rubén Uría, José Manuel Monje, David Bernabeu, Raúl Varela, Gerard Romero, Irene Junquera, Julio Maldonado 'Maldini', Roberto Gómez, Ricardo Rosety, Amalio Moratalla, Emilio Pérez de Rozas, Manolo Lama, Tomás Guasch, Juanma Castaño, Edu Aguirre, José Luis Sánchez, Sique Rodríguez, Lluís Flaquer, Paco González, Joan Laporta, Jota Jordi, Alfredo Duro, Jorge D'Alessandro, David Ibáñez, Damià López, Laia Coll, Carlo Ancelotti, Antonio Romero, Javi Amaro, Julio Pulido, Miguel Ángel Toribio, Roberto Antolín, Cristóbal Soria. [Bonus track: Tomás Roncero, Josep Pedrerol, José Luis Sánchez, Jota Jordi, Ana Garcés]Fuentes: El chiringuito de jugones (Mega), Onda Vasca, A diario (Radio Marca), El larguero (Cadena Ser), El desmarque (Cuatro), El partidazo de Cope, El Barça juga a RAC1. Hosted on Acast. See acast.com/privacy for more information.

A new research paper was published in Oncotarget's Volume 14 on March 24, 2023, entitled, “Polyisoprenylated cysteinyl amide inhibitors deplete singly polyisoprenylated monomeric G-proteins in lung and breast cancer cell lines.” Finding effective therapies against cancers driven by mutant and/or overexpressed hyperactive G-proteins remains an area of active research. Polyisoprenylated cysteinyl amide inhibitors (PCAIs) are agents that mimic the essential posttranslational modifications of G-proteins. It is hypothesized that PCAIs work as anticancer agents by disrupting polyisoprenylation-dependent functional interactions of the G-Proteins. In their new study, researchers Nada Tawfeeq, Jassy Mary S. Lazarte, Yonghao Jin, Matthew D. Gregory, and Nazarius S. Lamango from Florida A&M University College of Pharmacy Pharmaceutical Sciences and Imam Abdulrahman bin Faisal University tested this hypothesis by determining the effect of the PCAIs on the levels of RAS and related monomeric G-proteins. “To investigate the hypothesized anticancer mechanisms of the PCAIs through disruption of G-protein function, we checked the effects of the PCAIs on the G-protein levels in lung cancer (A549 and NCI-H1299) and breast cancer (MDA-MB-231 and MDA-MB-468) cell lines.” Following 48 hours of exposure, they found significant decreases in the levels of KRAS, RHOA, RAC1, and CDC42 ranging within 20–66% after NSL-YHJ-2-27 (5 μM) treatment in all four cell lines tested, A549, NCI-H1299, MDA-MB-231, and MDA-MB-468. However, no significant difference was observed on the G-protein, RAB5A. Interestingly, 38 and 44% decreases in the levels of the farnesylated and acylated NRAS were observed in the two breast cancer cell lines, MDA-MB-231, and MDA-MB-468, respectively, while HRAS levels showed a 36% decrease only in MDA-MB-468 cells. Moreover, after PCAIs treatment, migration, and invasion of A549 cells were inhibited by 72 and 70%, respectively while the levels of vinculin and fascin dropped by 33 and 43%, respectively. Their results show that PCAIs deplete the protein levels of some significant G-proteins which are known to be involved in the migration and invasion of cells (i.e., metastasis) such as RAC1, RHOA, and CDC42. These findings implicate the potential role of PCAIs as anticancer agents through their direct interaction with monomeric G-proteins. “The initial findings presented here indicate how PCAIs can be used as potent agents in developing new anticancer therapeutics, therefore, more extensive studies need to be done to elucidate on its potency. Although we cannot conclusively explain the exact mechanism of action of PCAIs on how they affect the levels of some G-proteins yet, but we can say that these PCAIs have the ability to affect the progression of cancer.” Research paper: DOI: https://doi.org/10.18632/oncotarget.28390 Correspondence to: Nazarius S. Lamango - nazarius.lamango@famu.edu Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords: PCAIs, G-proteins, KRAS, RHOA, RAC1 About Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

This week, please join author Trisha Singh as she discusses her article "Manganese-Enhanced Magnetic Resonance Imaging in Takotsubo Syndrome." Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass for the journal and its editors. We're your co-hosts. I'm Dr. Carolyn Nam, Associate Editor from the National Heart Center and Duke National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, Associate Editor, director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Carolyn, very interesting feature discussion this week. Many times we hear in magnetic resonance imaging the use of gadolinium contrast. And remember, gadolinium is an extracellular agent. And when we apply it in the heart, we look for infarcts, or areas of the heart that are perhaps dead, or scarred over. This week's feature discusses manganese as a contrast agent and it is an intracellular contrast agent. And very interestingly, it identifies calcium handling, so it's a marker of viability. And these authors are going to apply manganese as well as gadolinium in trying to understand mechanisms behind Takotsubo cardiomyopathy. But before we get to that, how about we grab a cup of coffee and jump into some of the other articles in the issue? Dr. Carolyn Lam: Oh, I'd love to tell you about the other articles. But just have to first say, I loved your description of the feature paper. It's right up your alley and I can't wait to learn more. But my first paper today I want to talk about pulse field ablation. Now, what is that? Pulse field ablation, or PFA, is a unique and novel technique to treat atrial fibrillation. It has a unique safety profile largely related to its preferentially for myocardial tissue ablation. And thus, sparing the esophagus and thus, deemed to have a unique safety profile. Now, a pentaspline catheter was the first such PFA system studied for AF ablation. And in the initial trials the catheter was used for pulmonary vein isolation and left atrial posterior wall ablation. However, following its regulatory approval in Europe, in clinical practice, physicians have ablated both these locations and expanded lesions that could be in closer proximity to the coronary arteries. Now, this is an unstudied important issue since preclinical and maybe some clinical data have raised the potential for coronary arterial spasm. Hence, the investigators led by Dr. Vivek Reddy from Icahn School of Medicine at Mount Sinai and colleagues studied the vasal spastic potential of PFA lesion sets, both remote from and adjacent to coronary arteries. Dr. Greg Hundley: Wow, Carolyn, this is a really interesting question. So what did they find? Dr. Carolyn Lam: In this retrospective analysis of a series of 25 patients undergoing PFA for atrial fibrillation in whom coronary angiography was performed pre, during and post ablation, they found that during pulmonary vein isolation and left atrial posterior wall ablation, coronary spasm did not occur. However, cavotricuspid isthmus ablation provoked severe subtotal vasospasm in five out of five consecutive patients. And this was relieved by in coronary nitroglycerin. ST elevation was not observed. No patient had severe spasm if first pretreated with parenteral nitroglycerin, either intracoronary or intravenous. And so in summary, coronary vasospasm was not provoked during PFA at locations remote from the coronary arteries. But when the energy is delivered adjacent to a coronary artery, like in cavotricuspid isthmus ablation, PFA did provoke subclinical vasospasm. And the phenomenon was attenuated by nitroglycerine administered either post hoc to treat spasm or as prophylaxis. And this is discussed in accompanying editorial, I like it, “Coronary Vasospasm in PFA Primum Non Nocere” by Drs. Estes and Sundeep and Saba. Dr. Greg Hundley: Very nice Carolyn. Very important research in this area using that particular methodology. Well Carolyn, my next study comes to us again from preclinical science. And Carolyn, this study evaluated mechanisms responsible for pulmonary hypertension. So as background, pulmonary hypertension is associated with increased expression of VEGFA and it's receptor VEGFR-2. But whether and how activation of VEGFA signal participates in the pathogenesis of pulmonary hypertension, that's unclear. And so these authors led by Dr. Yangxin Chen from Sun Yat-Sen Memorial Hospital and Sun Yat-Sen University evaluated VEGFA, VEGFR-2 signal activation and VEGFR-2 Y949 dependent vascular leak in lung samples from patients with pulmonary hypertension as well as in mice exposed to hypoxia. Dr. Carolyn Lam: Another one of those excellent translational pieces, isn't it Greg? So what did they find? Dr. Greg Hundley: Right Carolyn. So these authors found that pulmonary hypertension led to excessive pulmonary vascular leak in both patients and hypoxic mice. And this was owing to over activated VEGFA and VEGFR-2 Y949 signaling axis. Abolishing VEGFR-2 Y949 signaling via a specific point mutation was sufficient to prevent pulmonary vascular permeability and inhibit macrophage infiltration and Rac1 activation in smooth muscle cells under hypoxia exposure. This, in turn, led to alleviation of pulmonary hypertension manifestations including muscularization of distal pulmonary arterials, elevation of right ventricular systolic pressure and right ventricular hypertrophy. And so Carolyn, in summary, these results suggest that VEGFA, VEGFR-2 Y949 dependent vascular permeability is an important determinant in the pathogenesis of pulmonary hypertension and might serve as an attractive therapeutic target pathway for this disease. Dr. Carolyn Lam: Aw, thanks Greg for explaining that so well. The next paper talks about transcatheter aortic valve replacement of TAVR, recognizing that it is a well established treatment now for high and intermediate risk patients with severe symptomatic aortic stenosis. However, the question asked here is what makes some, but not all patients improve their left ventricular ejection fraction following TAVR associated after load reduction? Now, hypothesizing that circulating microRNAs may play a role here, the authors led by corresponding authors, Dr. Hosen and Jansen from University of Bonn and their colleagues profiled the differential expression of microRNAs in circulating extracellular vesicles in patients after TAVR. And in particular, the novel role of circulating microRNA 1225p in cardiomyocytes. Dr. Greg Hundley: Oh wow. So Carolyn, important study. So what did they find? Dr. Carolyn Lam: Well, first aortic stenosis increases circulating microRNA 1225p, which correlated with a lack of improvement of the EF in patients after TAVR. Extracellular vesicles harbored microRNA 1225p and facilitated its startling into the cardiomyocytes. Vesicular shuttling of this particular microRNA was regulated by a direct interaction with a multifunctional RNA binding protein called heterogeneous nuclear ribonucleoprotein U in a sequence specific manner. Extracellular vesicles containing the specific microRNA post transcriptionally repressed BCL2 an anti-apoptotic gene, which is central to cell viability and apoptosis. So in summary, Greg, an increase in extracellular vesicle microRNA 1225p in patients with aortic stenosis represents a novel mechanism for the deterioration of cardiac function in patients following TAVR. And pharmacological manipulation of this axis may improve ejection fraction and cardiac function in patients with aortic stenosis by improving the viability of cardiomyocytes, which opens the door to a potential therapeutic approach in patients with limited EF improvement following TAVR. Dr. Greg Hundley: Oh Carolyn, beautiful, beautiful description of that wonderful preclinical science. Well, let's reach into the mail bag and see what else is in the issue. And first, there's a research letter by Professor van Raalte entitled “Kidney Hemodynamic Effects of Angiotensin Receptor Blockades Sodium Glucose Co-transporter 2 Inhibition Alone and in Their Combination: A Crossover Randomized Trial in People with Type 2 Diabetes.” And Carolyn, there's also an In Depth piece from Dr. Marx entitled “GLP1 Receptor Agonist for the Reduction of Atherosclerotic Cardiovascular Risk in Patients with Type 2 Diabetes.” Dr. Carolyn Lam: Very, very nice papers, those two. There's also an exchange of letters between Drs. Hou and Sedej regarding the article, “Fine Tuning Cardiac Insulin Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity.” As well as a Perspective by Dr. Eagle, “Comments on the 2022 Aortic Guidelines: Seeking More Precision in Aortic Care.” Now, let's go onto the feature discussion of all things MRI, shall we? Dr. Greg Hundley: You bet. More on manganese. Welcome listeners to this very interesting feature discussion on December 13th. And we have with us Dr. Trisha Singh from the University of Edinburgh in Edinburgh, Scotland. Welcome, Trisha. This is a fascinating study incorporating manganese cardiovascular magnetic resonance to study some of the mechanistic underpinnings of hypokinesis left ventricular hypokinesis in patients with Takotsubo syndrome. So maybe just describe for us some of the background information that went into the preparation of your study, and what was the hypothesis that you wanted to address? Dr. Trisha Singh: Yes, of course. So we know with patients with Takotsubo syndrome, it predominantly affects middle aged women, patients present with a degree of left ventricular dysfunction, which is transient. And, unfortunately, it can be quite difficult to diagnose because it can phenotypically present very similar to an acute coronary syndrome. We know from previous studies that these patients do have ongoing symptoms despite normalization of their LV function. And actually their outcomes are not as benign as previously thought. In terms of manganese enhanced MRI imaging, we at Edinburgh University have imaged patients with other cardiac conditions such as hypertrophic cardiomyopathy, and dilated cardiomyopathy. And have established that it can be used as a surrogate marker of myocardial calcium uptake and handling. So we were very interested to see whether or not patients with acute Takotsubo syndrome have got a myocardial calcium dysfunction and more importantly whether or not this translates into long-term dysfunction and perhaps could explain their symptoms and worse prognosis in long-term. Dr. Greg Hundley: Trisha, manganese MRI. Now, we hear about gadolinium MRI, how is manganese different? You mentioned it's a nice marker for calcium handling. Is this widely used clinically? What kind of contrast does it provide? Dr. Trisha Singh: So manganese was actually one of the first contrast agents to be used with magnetic resonance imaging. It kind of came about in the 1970s and 1980s. And previous animal models have looked at how it is essentially an intracellular contrast agent. And what I mean by that is manganese is a calcium analog and therefore, in cells where they are viable and there's intact cell function, they will be taken up through a voltage gated calcium channels. So, for example, in the heart. So the theory is that manganese, when you've got normal viability, manganese is taken up into the myocardium via voltage gate calcium channels. And several studies have shown that if you then have disease myocardium, these tissues do not take up the manganese as normal tissue would. And the main difference between manganese and gadolinium is they are both paramagnetic, which is why they're helpful and useful in MRI. But gadolinium, as a compound, is too big and it cannot cross an intact cell membrane and therefore, gadolinium is more extracellular. And as, we know, accumulates in tissues where there is increased edema, or water content. So gadolinium, for all intents and purposes, is incredibly useful contrast agent, certainly what we use predominantly at the moment in clinical practice, but it is extracellular. So the theory behind manganese is that it is an intracellular contrast agent as opposed to gadolinium. And where gadolinium accumulates in disease tissue, manganese accumulates in viable tissue. So they behave almost kind of in contrast to each other. And currently, manganese is not used in clinical practice. I think the only clinical compound contrast agent utilizing manganese was mangafodipir, otherwise known as Teslascan, which I believe came off the market in 2012 and that was predominantly used for imaging liver metastasis. Dr. Greg Hundley: Well Trisha, thank you for clarifying for us the difference between manganese, the intracellular contrast agent, and gadolinium, the extracellular contrast agent, that's so widely used clinically. Well, with that description, can you describe for us now, your study population and your study design? Dr. Trisha Singh: Perfect. So the study population was we aimed to recruit 20 patients with acute Takotsubo syndrome. The diagnosis of Takotsubo syndrome was based on a clinical diagnosis, so all our patients underwent a baseline echocardiography and invasive coronary angiography. Now, for us, the coronary angiography was quite important because we wanted to ensure we ruled out anyone with an acute myocardial infarction, which can often be tricky in this cohort of patients. So after recruiting 20 patients during the acute phase of Takotsubo, they all underwent a baseline gadolinium enhanced MRI scan followed by a manganese enhanced MRI scan. And these were done at least 48 hours a part. And then about three months roughly after the acute index, they were all invited to participate in a second manganese enhanced MRI scan. Dr. Greg Hundley: Very good. So two exams separated longitudinally over time. What were your study results? Dr. Trisha Singh: Our results demonstrated that during the acute phase as one would expect, patients had a degree of left ventricular dysfunction. The majority of our patients had afibrillar Takotsubo, so had afibrillar ballooning with preservation of the basal segments. With this, we also noted that in the areas that were affected by Takotsubo, so kind of the mid ventricular wall and the apex that all patients had significantly elevated native T1 and associated T2 as well. And as we expected there was reduced uptake of manganese and therefore kind of reduced calcium uptake in the myocardium in the area affected by Takotsubo syndrome. Interesting, what we also noticed was that all these patients had significantly elevated LV mass, which has been described in previous Takotsubo papers, certainly by Professor Dawson. And when you measured the left ventricular wall thickness, the LV wall thickness is elevated in the affected and actually not even in the non-affected areas, which I suspect explains why in the acute phase people almost doubles up which kind I guess fit with kind of acute myocardial edema and intense water content. And then, three months later when these patients returned for their follow-up scan, a lot of the acute changes had resolved. So native T2 values had improved and gone back to baseline. Native T1 and post contrast T1 values had remained elevated compared to the control population. And what we found was that manganese uptake, though it had improved, it still remained abnormal and reduced compared to the control population, which is a finding that we weren't expecting to find. Dr. Greg Hundley: Very interesting. So acutely we've got extracellular water there, elevation of myocardial T2, and also impaired manganese uptake. So intracellular abnormalities with calcium handling. Then later, so three months later, we have restoration of myocardial T2 so the extra water content is absent, but we have impaired manganese uptake indicating an abnormality with calcium handling. So how do we put this all together mechanistically? What does this tell us about the pathophysiology of Takotsubo syndrome? Dr. Trisha Singh: For one thing, I think we can say that there is, as described before, there is obviously intense myocardial edema present in patients with acute Takotsubo. And I think the significant elevation in T2 and LV mass kind of all fits together. Actually interestingly, as native T2 improves in their follow-up scans, the LV mass actually all return back to normal baseline. So I think the acute edema does resolve. And as you said, interestingly, despite all of these patients, their LV function completely recover. And despite that their myocardial calcium uptake, or handling remain normal. And I think that's not been demonstrated before. And I think it just points to that there is obviously, still something going on in the myocardium and it's not behaving completely normally despite completely normal kind of gross LV function. And potentially, this might point in the direction of why these patients have ongoing symptoms. So, certainly, from our observational cohort group, about 70% of patients had ongoing symptoms and this was predominantly breathlessness and palpitations. And potentially, might be related to why patients have worse outcomes compared to the general population. Dr. Greg Hundley: Very nice. And Trisha, can you describe, was there a therapeutic intervention between the acute and then the three month later measurements? Were these patients administered any type of medical therapy and were there differences in what those therapies may have been between different patients in your study? Dr. Trisha Singh: So predominantly, most of the patient population that were started on some combination of heart treatment due to the baseline LV dysfunction. And this kind of was a combination of most of them were on Ramipril, a few of them were also on spironolactone or eplerenone. And then, every single one was on furosemide. And interestingly, I mean I appreciate, I think the population group was quite small, so it's very difficult to compare those that were on kind of full heart failure treatment versus those who were just on beta blocker and ramipril therapy. But even in that cohort there was a split of about, I think predominantly, I think 17, 16 patients were on kind just beta blockers and ramipril as opposed to beta blocker, ramipril, spironolactone. And there was no difference kind of in the recovery in manganese uptake in that cohort. But, again, the numbers are quite small, so I think it's difficult to extrapolate any kind of true meaning in that. Of course, we know there's a lack of randomized control trial data looking at how to best treat patients with acute Takotsubo syndrome and certainly, what treatment may prevent these patients from having a recurrence of Takotsubo. And I know some of the TACA registry data has looked at actually despite the fact patients of being on beta blocker, or ramipril therapy, they still go having recurrence of Takotsubo and certainly of our cohort, one of our patients went on having a recurrent episode of Takotsubo within a year of her index event and she was on aspirin, beta blocker, spironolactone as well. Dr. Greg Hundley: Very nice. And then lastly, when you made these measurements looking at the manganese uptake or lack thereof, were these in the regions of myocardium where you mentioned many had apical LV wall motion abnormalities, were they in those regions or did you also measure regions remote to where the wall motion abnormality occurred? Dr. Trisha Singh: Of course. So we took measurements in the affected regions of the heart that kind of demonstrated spironolactone syndrome. And we also took measurements in kind of, so to speak, the remote segments of the heart. Now, for the remote segments of the heart, we could only measure native T1 and post contrast T1 at 30 minutes and to measure manganese uptake well, unfortunately, what we have to do is take a measurement over time, so we'd do every two and a half minutes for 30 minutes after the manganese contrast. So we weren't able to calculate manganese uptake in the remote regions. But what we could do was measure the native T1 in the remote region, and then the post contrast T1 and see how it differed with the region of interest in the affected portion of the heart, so to speak. Dr. Greg Hundley: Very good. Well, Trisha, with this really exciting research and very nice methodology, what do you see as the next study to be performed in patients with Takotsubo? Dr. Trisha Singh: So I think, in terms of manganese enhanced imaging, I think it'd be really interesting to re-scan these patients at one year or at two years. And the question there is whether or not their manganese uptake ever recovers really. I know we previously talked about this and thought about whether or not these patients who go onto developing Takotsubo syndrome might actually have a kind of an underlying cardiomyopathy that puts them at risk of developing Takotsubo with stress. So it'd be interesting to see whether or not actually their calcium uptake ever recovers in the long-term, or whether actually they have more of a chronic heart failure type like picture. And I think another area of interest would be to see potentially using manganese imaging as a noninvasive measure of kind of myocardial calcium activity and to see whether or there's any changes with therapy over the course of months to years or so. Dr. Greg Hundley: Very nice. Well listeners, we want to thank Dr. Trisha Singh from University of Edinburgh in Edinburgh, Scotland for bringing us this really interesting article in patients with Takotsubo syndrome demonstrating that there is a marked perturbation of myocardial manganese uptake, which is most evident in the acute phase of Takotsubo presentation, but also persists for at least three months despite apparent restoration of normal left ventricular ejection fraction and resolution of myocardial edema. All of this suggesting that abnormal myocardial calcium handling may be implicated in the pathophysiology of Takotsubo syndrome. Well, on behalf of Carolyn and myself, we want to wish you a great week. And we will catch you next week on the run. This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, please visit ajjournals.org.