Podcasts about biggin

Charles from Biggin & Scott St Kilda is calling Will to hopefully give him is werribee rental yayyyyyy what a time that could beHe just needs to check the references to make sure will is allllllright Youtube:https://www.youtube.com/@smellinggoodproductions8760 Instagram:@smellinggoodproductions @conkconkconkconk@williamboyd__See omnystudio.com/listener for privacy information.

Have to say this was a vibe! Went in on the UKG, House, D&B finishing with the DJ F Swift the Sharky Sharky R's & B's and the DJ Manic R's & B's Yeah! Yeah! I just love mixing and always had a passion for Djing since year 2000 when I purchased my mk2 Technics 1210's Oooooh YEAH!!!! Will be throwing it down differently as per...... on the Pioneer this Friday 8 'til Late www.manicfm.com Biggin' up the MASSIVE Ooooh Ahhh Ooooh Ahhhh! respect to everyone for coming on the show always love your vibes. Thank you guys.

Throwing down the best UKG, House & R&B on the SL1210's mk2 DVS vinyl OOOHH YEAHHHH!

In the preface to Les Fleurs du mal, Baudelaire indicated that boredom is the truest suffering, andthis idea later became central to the fin de siècle movement, an era of decadence in which artificemasqueraded as, or was even elevated to the status of, art. The Belladonna Invitation by Rose Bigginis a Gothic exploration of the […] The post The poison salon – with Rose Biggin first appeared on Breaking the Glass Slipper.

Today we're joined by industry legend Neil Biggin in an absolutely massive show! Neil regales us with hilarious stories as we cover a wide range of his electronic music during his time at Gremlin Graphics from about 1992-1996. He walks us through some memories of landmark events during the 16 and 32-bit eras: the launch of the CD32, the first days of the Playstation, and being at a company with one of the world's first motion capture studios. Neil Biggin began his career with Zool 2 on Amiga, and continued with games like the CD32 versions of Zool 1 and 2 and Top Gear 2, Top Gear 3000, the Actua (or VR) sports games, Loaded, Re-Loaded, a number of FIFA games from 1997-2000, and music porting duties for the Desert/Jungle Strike games. His earliest works are teeming with the lovely sounds of Rave and House music, but as his sound progresses he gets deeper into other genres like Metal, Jungle, Drum and Bass and much more. Whether you're new to his work or an old fan, Neil's music continues to sound great to this day. Neil is also in the process of re-releasing much of his music. Check out his Spotify as more gradually starts appearing over the coming months. He's also working on the latest iteration of the Amiga Immortal album series where Amiga legends like himself, Barry Leitch and many others come together to remaster their own works for modern audiences. Neil's Links: Spotify | SoundCloud | Twitter The kooky song that Neil was thinking of was indeed Martian Hop by the Ran-Dells, a kitsch classic that's still pretty entertaining today. Track List: All tracks composed by Neil Biggin unless otherwise stated. Tracks marked with a * indicate previews, newly released tracks or exclusive unreleased material shared from Neil. 0:00:00 Zool 2 - Mount Ices (Amiga) 0:08:09 (Bedding) Zool 2 - Bulberry Hill (Amiga) 0:12:38 Zool - Track 6 (CD32) 0:25:51 Top Gear 2 - Track 1 (CD32) 0:33:18 Top Gear 3000 - Track 2 (SNES) 0:40:15 (Bedding) Top Gear 3000 - Track 3 (SNES) 0:44:32 (Excerpt) Zool 2 - Bulberry Hill (Remaster)* 0:44:54 (Bedding) Desert Strike - Title (DOS - Adlib) 0:47:57 (Bedding) Jungle Strike - TItle (SNES) 0:50:07 Bedding) Jungle Strike - The Madman's Son (SNES) 0:51:00 (SFX) Jungle Strike (SNES) 0:51:43 Premier Manager 3 - Title (Amiga) 0:59:48 Loaded - Track 6 (PS1) 1:14:24 Zool 2 - Tooting Common (CD32), demo also used in Loaded as a hidden track 1:19:48 Actua Golf - Main Menu (SAT) 1:26:19 Actua Golf - Options (SAT)* 1:38:59 Re-Loaded - Purpid (PS1) 1:59:40 Shoot For Loot - Title Theme (Arcade)* 2:01:22 Shoot For Loot - Track 5 (Arcade)* 2:15:54 Hardcore 4x4 Flea's Dreams (PS1 - Unreleased OST)*

A very special podcast to wrap up the end of the year. For the second year I decided to go back, listen and re-listen to all the great interviews that happened in the last year and pick some of my favorite pieces and add commentary on why that piece was important and how in most cases it helped with the direction for my business. From best accounting principles to the importance of the email list, aha moments that led to award-winning spirits, starting a distillery staying small, working hard and stop being romantic about the business, the importance of a break-even analysis, focusing on what you do best, accepting money, diversifying your income streams and the concept of a core occasion for your spirits' brand.

Biggin up the MASSIVE Who locked in last night! YOu were large out there! Felt the love, Playing all the best Newer & older UKG that I havent played previously on any of my shows then went IIN Hard on the old skool UKG classics at the end! It's how I'm doing it! As always fast and furious drops on a lot of mixes, Bare amounts of tracks played!

Join WRBI News Director Tom Snape, and the rest of the WRBI Crew, for enlightening conversations with fascinating people in Southeast Indiana. Brew up your favorite beverage, relax, and listen every weekday morning at 9:30.

In this episode of the Distillery Nation Podcast, I had the absolute pleasure of talking with Alex Myers. Alex is the distiller behind Big Gin, and what a better way for episode 99 of the podcast than to go back and check on Big Gin, which was our very first distillery podcast. And it was during those early visits at the original Big Gin (Captive Spirits) distillery, that gave me enough confidence that I could start small. So, we brought Alex to talk about the last 7 years, what has changed, how he stays focused on producing Gin and only Gin, new expressions, how they keep consistency over batches and so much more!

DJ V SMOOTH ROLLING THROUGH THE BUILDING UKG HOUSE MEGAFLEX BUSINESS 17.7.22 Last week was an actual vibe Biggin up my Donny G's locking in & locking on inside, 'nough love! 'pon deck as we speak getting the fires ready again for tomorrow, Sunday Flex up! On the BIG & BAD www.manicfm.com

This week we are Rabless but Grado tags in a heavyweight as Cultaholic's Tom Campbell joins him. Talking Vince, Forbidden Door and of course the Biggin in Wigan! Plus your Bury/Putovers, Bubba Ray in Glasgow and could Michael Barrymore be Grado's manager? Episode CXXVI is here, ring the bell! Get more content at patreon.com/wrestlingdaft and get a 14 day trial for Shopify at shopify.co.uk/wrestling 

DJ V SMOOTH ROLLING THROUGH THE BUILDING UKG  MEGAFLEX  BUSINESS 20:00 - 21:00 13-03-2022 Wow what can I say I thoroughly, thoroughly! Enjoyed that! Biggin' up the MASSIVE and the crew inside the place, Dropping the bangers house n garage, fast & furious, you know how I'm doing it! Love to the crew locking in locking on, all the crew, Large up Denise M, Simon J, Peter S,  Calvyn N, Vicky L & DJ Trickadee, also to the management, out to the text crew sending the messages through, happy to have the new listeners, your time! thank you very much, hope to see you next week, more fast paced fires as always!

Fraser Lack is a Sales Executive at Biggin & Scott. See acast.com/privacy for privacy and opt-out information.

Biggin' the up MASSIVE Locking in & Locking on, All my favourites guests, Large up I Love Garage crew DJ Krazy G with our own Manic FM & Unity DAB DJ  DJ Manic dropping by MASSIVE in the game,  Enough respect, great to see you guys on the stream,  OVERTIME business, PLAYING my Favourite tunes from my favourite artists, including Charlotte Devaney & Shosh Oshbegosh, Leanne Louise, Colourgirl, Jade magic, MC Kie, Craig David & many more, Lots of BIG tunes, ample classics, The Boss DJ Manic giving it the thumbs up, so I know it was a good performance, last 45 minutes was random selections, with random song requests from viewers, that's how we're doing it LIVE at The BIG The bad one & only Manic FM, I really enjoyed that. Hope to see you all next week.

On this episode of The Score, we're speaking with Dr. Karen Symms Gallagher, professor of education and the Hagen Chair in Women's Leadership in the Rossier School of Education at the University of Southern California, where she also served as dean for 20 years. And Dr. Mark Biggin, a staff scientist in molecular biology at Lawrence Berkeley National Laboratory. He also teaches at UC Berkeley. Kathryn Baron (02:30): Dr. Biggin, … what happened that revealed this dark side [of cheating] to you? Dr. Mark Biggin (02:41): Oh, oh, direct experience from a class I was teaching. During the lockdown, suddenly we were giving exams that were unproctored online as opposed to proctored in person. I assumed that if we just told the students to follow the honor code, they would do that. I didn't imagine many students would cheat, but the readers, for the first time I was doing this, pointed out they found two students who obviously had copied their answers. They were very similar. Dr. Mark Biggin (03:08): From there, being me, somewhat an analysis person, I started doing a statistical analysis and I found that some of the students had very usually similar question scores. They got the same scores for many questions, and so the greater scores. When we looked at the written answers of those students, we found that many of those had cheated and the students that we challenged, most of them confessed.Dr. Mark Biggin (03:30): Through some iterative process, we kept finding more and more students who cheated. We eventually found that in that particular class, it was the worst case we had actually. 19% of the students in the end, we found had cheated. I was floored. I kept saying, "Oh, I found say five or six groups, 15/17 students." Said, "Oh, well that must be most of them." Then one of the students who cheated said, "Oh, no, no, no, I bet there's more than that." Dr. Mark Biggin (03:58): That student was right, and just kept going. That was my entrée. Dr. Mark Biggin (04:29): Well, it's important to say these were online exams which were unproctored. They were actually open books, so students were allowed to look at lecture notes, but that wasn't sufficient for some of the students. What they do is they first go through and answer all the questions they can answer and then they collude by just literally sending an email with ... or in some way, a text, whatever, literally the entire exam that they've written. They copy those answers from their colleagues that they didn't know the answer to. Dr. Mark Biggin (05:24): It's just wholesale copying. When you look at some of the copied answers, so a chemical structure, they copy it minutely. It's not that they ... They're really just blindly copying. This is not an intellectual collaboration. This is blind copying. Dr. Karen Symms Gallagher (10:40): In the last couple of years, we've had over a thousand cases that have been referred to SJACS, [ the student run process for academic integrity cases at USC] not exclusively for cheating, but between the fall of 2019 and the fall of 2020, there was 115% increase in cheating, reported cheating by faculty. Most of it was what we call contract cheating. It was collusion, looking up answers during a test. Again, a lot of unproctored tests. It was, like many universities, we rapidly went into online education through Zoom, and we saw this increase of reported cheating. Dr. Karen Symms Gallagher (12:10): We know the saying, there's an app for that. Well, when it comes to cheating, there are hundreds of apps for that. That is because contract cheating, which really is outsourcing answers or essays for an exchange of money, is very lucrative. In the last 10 years alone, there have been a sizable investment by venture capitalists in apps that clearly are cheating apps. I mean, they say they're for homework help, but they're inexpensive. Dr. Karen Symms Gallagher (12:49): They're like signing up for Netflix so it's possible for almost any student to use these apps. Now, be clear, we've had cheating like this. We've actually had what you call contract cheating, but it was usually something that students who had the resources, either the money or the ability to find people have used. But with these apps ... And as an aside, I'm not naming any of them. I don't think that's the important part on this. Dr. Karen Symms Gallagher (13:22): It's just that it is very lucrative for these for-profit ed-tech companies. They advertise on social media so that students are inundated, whether on Facebook or Twitter they get advertising for this. It's in a kind of advertising that appeals to students about how overworked they are, how awful COVID is, let us help you. Dr. Karen Symms Gallagher (13:53): We can not only help you with your answers to your math problems and your ... in the STEM fields, but also, we can write that essay for you with little as a couple of days' notice. In exchange of money, we can have someone write that five-page paper for you, all the way up to we can have them write your research paper. Again, it's the number of commercial cheating apps out there and their ability to advertise in places that they'll find students. Dr. Mark Biggin (17:49): We get a median of 4% of students cheating across all the exams we've looked at, but it varies greatly by class. Some classes seem to have a more persistent problem, probably because they're considered by the students to be high value because they're important. One that I teach is required for medical school and that's one we've had the biggest problem with. That speaks to ... I think is telling you to some extent why students are doing this. Dr. Mark Biggin (18:52): I think academics are to some extent a little naive at ignoring that [economic] incentive. It's an enormous effect. As to the harm done, we've already discussed I think the ... If students know that other students are cheating, although only a minority cheat, the rest of the student body are aware this is happening, particularly during the pandemic. But if you have a lot of online courses or those courses where people can cheat and do cheat, the other students know. Dr. Mark Biggin (19:19): If the administration, the faculty aren't making what are perceived to be sufficiently effective attempts to mitigate and stop that cheating, it creates a pall over the environment. Sort of the sense of trust and comfort with the system is corroded somewhat. Dr. Mark Biggin (20:30): Well, because most classes the students are judged relatively to the other students, for every student who goes up a grade, an honor student who didn't cheat goes down a grade. 10% of students cheating, that's 20% of the grades are inaccurate. 10% got a grade too high and 10% a grade too low. Dr. Karen Symms Gallagher (21:47): Yes. I agree very much with Dr. Biggin, that we have to do something as the administrators and as faculty. We cannot let students prosper from cheating. In the long run, if we erode the belief in the academic integrity of a college, a school, a department, we all suffer. Dr. Karen Symms Gallagher (22:19): That is probably the most insidious part of cheating in general, but these contract cheating, these companies, these websites, these applications that are flagrantly selling cheating kinds of services. It is up to us. I think we, both administrators working with faculty and working with students, because the other students ... I mean, it's right. Other students don't want the cheating to go on.They know it not only harms them on a grade, but in the end, it can harm the value of the degree that they get. Dr. Mark Biggin (25:06): Well, the physicists are always telling us if you haven't measured it, you haven't understood it. The first thing you have to do is measure the amount of cheating, the different forms of cheating that are occurring and know when and where it's occurring. Dr. Mark Biggin (26:55): We've been able to reduce cheating by about twofold, by informing students in advance of the method, and actually showing them the website and the website has a specific page addressed to the students explaining that our goal is not to catch them, but to dissuade them and to tell the honor students, "We're doing this. Don't feel threatened. We're doing this to make sure you get the grade you deserve." Dr. Mark Biggin (27:20): I assumed cheating would plummet. It dropped about twofold. I still had 7% in my class this last summer collude, even with all that information and telling ... The website explained to them, "You'll be caught if you cheat." And they cheated. In fact, one of those students had been caught in the term before in the class, was failed, took the class again, cheated again, and was caught again. Dr. Karen Symms Gallagher (32:08): I really want to pick up on this notion of measuring it. I found out about the 115% increase in SJACS at USC through a student publication. We do not publish what's going on at USC in our handling of student disciplinary actions, nor do most universities. In fact, I went through several student newspapers to find that there's been this increase since the pandemic forced most classes to be online. Dr. Karen Symms Gallagher (32:44): Well, if you don't know what's going on, you're both unaware, but also there's not much we can do about it until we recognize it is an issue. Measuring it, that is seeing again reported issues. A lot of cheating does not get reported because faculty members say, "I'm the bad person if this happens. Students will give me bad reviews on my end of the semester." It destroys the teacher-student relationship.

Pete Ray Biggin is part of the finest drumming talent from the UK. His raw power and phenomenal talent has led him to gigs with Amy Winehouse, Mark Ronson, Chaka Khan, Adele, Robbie Williams, and currently, Level 42 We talk to Pete about his career, gear and much more! Follow Pete on the Socials: https://www.peteraybiggin.com/ https://www.facebook.com/Pete-Ray-Biggin-126983733989244/ https://www.instagram.com/peteraybiggin/ https://twitter.com/peteraybiggin?lang=eu

Kyle Barnes talking all things real estate with Kim McQueen from McQueen Real Estate, Rae Corris from Biggin & Scott Daylesford, Rob Broadhurst from Broadhurst Property and Annette Leary from Belle Property, while Donna Kelly chats to Real Estate Institute of Victoria president Leah Calnan.

Yes indeed fam, keep striving for your success. You've come a long way, now keep getting up. We're not just the music, we're all about inspiring you to make it happen as well. Now, onward with the show. In this episode, we bring it back with the great Al Jarreau, with a splash of George Benson & Boz Scaggs, a little bit of Dayton, High Fashion, awesome slow jams from The Bill Henry Band, Frank McComb, Deborah Bond, and the list goes on and on. If you have a request, drop us a line at greatsoulradio@gmail.com. For all of the artists you hear on this episode, go and support their music on all platforms. Thanks as always for tuning in, and remember---Tell a friend, to tell a friend, to tell a friend, all about The Throwback Lounge. It's not just a show....IT'S AN EXPERIENCE!! 1 LOVE ;) LEAD-IN CUT: WE ARE ON THE MOVE-ZO! OPENING CUT: MY WAY- SIDE EFFECT 1. GIRLS KNOW HOW-AL JARREAU 2. LOVE X LOVE-GEORGE BENSON 3. LOWDOWN-BOZ SCAGGS 4. SPACE PEOPLE-FAZE O 5. SATURDAY, SATURDAY NIGHT-ZOOM 6. OUT TONIGHT-DAYTON 7. FEELIN' LUCKY LATELY-HIGH FASHION 8. HOLD TIGHT-CHANGE 9. LET'S DANCE-TOM BROWNE 10. S.O.S.(DIT DIT DIT DAT DAT DAT)-S.O.S. BAND 11. BIGGIN'-WEEKEND PLANS 12. STAY THIS WAY-THE BRAND NEW HEAVIES 13. LET'S DANCE-DAVID BOWIE 14. STOP! DON'T TEASE ME-DEBARGE 15. DON'T TELL ME-CENTRAL LINE 16. DANCE TURNED INTO A ROMANCE-THE JONES GIRLS 17. CAN'T FAKE THE FEELING-GERALDINE HUNT 18. I'M TOTALLY YOURS-HI GLOSS 19. DESIRES-RAFAEL CAMERON 20. CHECKING YOU OUT-AURRA CHAMPAGNE HOUR 21. GET MY LOVE-THE BILL HENRY BAND 22. UHH AHH(SEQUEL VERSION)-BOYZ II MEN 23. BEAUTY-DRU HILL 24. BABY GET YOURS TONIGHT-LONDON JONES 25. BABY, I WANNA-H TOWN 26. UMM UMM GOOD-MEN AT LARGE 27. ALL NIGHT & ALWAYS-MICHAEL STERLING 28. ALL I EVER ASK-NAJEE FEAT. FREDDIE JACKSON 29. I LIVE FOR YOUR LOVE-NATALIE COLE 30. IF YOU SAY MY EYES ARE BEAUTIFUL-JERMAINE JACKSON FEAT. WHITNEY HOUSTON 31. THE LADY IN MY LIFE-MICHAEL JACKSON 32. VERY SPECIAL-DEBRA LAWS 33. WHEN YOU NEE ME-WILL DOWNING FEAT. CHANTE MOORE 34. NEVER LETTING GO-FRANK MCCOMB 35. SWEET LULLABIES-DEBORAH BOND 36. THE REASON I LOVE-ALEX LATTIMORE 37. IT'S LIKE MAGIC-BLUE MAGIC 38. SILLY LOVE SONG-ENCHANTMENT 39. I'M ON FIRE-CHAMPAIGN CLOSING CUT: I GOT THE LOVE-STARPOINT

Jacklyn Biggin is a Senior Developer at the Royal Bank of Canada. Jacklyn studied Digital Media at the University of Leeds in the UK, and in March of 2020 at the onset of the COVID-19 pandemic she founded and was the lead organizer of Hack Quarantine, a 3-week online hackathon with thousands of participants. Today, in addition to working at RBC she is everyone’s favorite hackathon coach and creates awesome content for Major League Hacking. Shownotes: Follow Jacklyn on Twitter (https://twitter.com/JackBiggin), connect with her on LinkedIn (https://www.linkedin.com/in/jackbiggin/) and subscribe to her YouTube channel (http://dontforgettolikeandsubscribe.com/) Get your limited edition GrizzTech Talks sticker at https://forms.gle/fPzYAZkUmqud8HzB6.

This weeks been a Biggin. I flew to Sydney to shoot the cover for the next book! It was so exciting to start seeing this little dream come to life. In this episode I share a bit of the prep that went into the shoot, what I changed about my diet and exercise in the lead up to feel the most confident I could. I tried a few new spots in Byron too! I hit up a new yoges space, and tried an infrared sauna.Hope you enjoyed Gaia episode on Monday, heading back there next weekEditing manuscript has been my other main focus this week which is exciting and scary.Big love from Byron Bay,Lola Follow Lola Berry on Instagram: @yummololaberrywww.lolaberry.comwww.lolacoffee.co See acast.com/privacy for privacy and opt-out information.

Hyping the Dragon’s new hairdo | Time - 5:07 Tiger HBO Documentary review | Time - 08:00 NFL STUFF | Time - 51:25 Biggin’ up Bills Mafia  The Dragon’s plea to the NY Giants front office to trade for Deshaun Watson Philip Rivers retires LA Chargers hire Brandon Staley MLB STUFF | Time - 1:26:52 D.J. LeMahieu inks 6-year, $90M deal w/ NY Yankees NBA STUFF | Time - 1:32:06 LA Clippers report Yo ... the Bulls and Billy Donovan?!?!  Kevin Durant’s excellence and Bucks-Nets recap

Burrumbeet Racing Clubs Steve Biggin chats to Andrew Kuuse re N' Years Meeting

Join me as we go on an English pub crawl with the WW2 Airmen of RAF Biggin Hill. Support Warbirds and Get BONUS EPISODES https://www.patreon.com/warbirdspodcast?fan_landing=true Email Me: dan@talesfromabove.com Biggin on the Bump - Bob Ogley Spitfire Crash - Kings Arms - Aviation Safety Network The Queen's Head - Four Square City Guide Bombs, Bees, and Bravery - BBLHS Biggin Hill - Wikipedia Seeking RAF Biggin Hill - Biggin Hill Memorial Museum

It's all going down in the long-awaited Episode 18. We're talking spiritual moon poetry, BIGGIN' UP new Irish music and preaching the freedom of the nipple!! Poem: 'For the Passionate Ones' by Rupi Kaur Songs: 'Up de Flats' by Gemma Dunleavy and 'The Keys' by Matt Duncan

Biggin up black businesses

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.18.209858v1?rss=1 Authors: Wu, Z., Newstead, S., Biggin, P. C. Abstract: The endoplasmic reticulum (ER) is the main site of protein synthesis in eukaryotic cells and requires a high concentration of luminal chaperones to function. During protein synthesis, ER luminal chaperones are swept along the secretory pathway and must be retrieved to maintain cell viability. ER protein retrieval is achieved by the KDEL receptor, which recognises a C-terminal Lys-Asp-Glu-Leu (KDEL) sequence. Recognition of ER proteins by the KDEL receptor is pH dependent, with binding occurring under acidic conditions in the Golgi and release under conditions of higher pH in the ER. Recent crystal structures of the KDEL receptor in the apo and peptide bound state suggested that peptide binding drives the formation of a short-hydrogen bond that locks the KDEL sequence in the receptor and activates the receptor for COPI binding in the cytoplasm. Using quantum mechanical calculations we demonstrate that the strength of this short hydrogen bond is reinforced following protonation of a nearby histidine, linking receptor protonation to high affinity peptide binding. Protonation also controls the wetting of a cavity adjacent to the peptide binding site, leading to a conformational change that ultimately allows the complex to be recognized by the COPI system. Copy rights belong to original authors. Visit the link for more info

OH BABY ITS A BIGGIN! Join the Red Panda Pirates as Monk3yDShadow, Raihne88, and Deni257 discuses Nibiru, Giants, and how they ware proclaimed in the Bible! So lets raise anchor and lets get sailing! Make sure to follow us on Social Media: Twitter Twitch Anchor YouTube Facebook If you would like to help support us you can do so here: Streamlabs Anchor Teespring Check out our affiliates and Save 10% off your purchase by using the code "RedPandaPirates" Noname Nerd: Stop dressing like the rest and make your name known today the dopest custom jerseys today! Triumph Chairs: Where all chairs are specially built for the best performance, comfortability, and durability! -- Watch live at Twitch --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/redpandapirates/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.11.145466v1?rss=1 Authors: Epstein, M., Maxwell, S., Piggot, T. J., Beeson, D., Bermudez, I., Biggin, P. C. Abstract: Muscle nicotinic acetylcholine receptors are a class of heteropentameric ligand-gated cation channels with constituent subunits adopting a fixed stoichiometric arrangement. The specific amino acid residues that govern subunit ordering are however, only partially understood. By integrating all-atom molecular dynamics simulations, bioinformatics, two-electrode voltage clamp electrophysiology and 125I--bungarotoxin assays of chimeric nAChR subunits, we identify residues across the extracellular, transmembrane and extended M4 helix of the {delta} subunit that make structural signatures that contribute to intransigent assembly rules. Furthermore, functional differences observed in 2{delta}2{beta} receptors can be rationalized by changes in dynamical behavior that manifest themselves at the agonist binding site. Copy rights belong to original authors. Visit the link for more info

I read from big brother to biggin.   The word of the episode is "Bigfoot". https://en.wikipedia.org/wiki/Bigfoot     dictionarypod@gmail.com Facebook Twitter Instagram Patreon 917-727-5757

We chat with James Biggin from Steel City. To start the episode, we talk about the power of branded merchandise in marketing and how it fits when compared with other channels. We also talk about how there is much more to branded merch than pens and mugs. In fact, there are thousands of different items that brands can use in order to make a lasting impression. An interesting part of this section is when James talks about how branded merch isn’t just for clients. It can be used is several other ways too! As we move through the episode, James also shares some of the secrets of the industry as well as talking about budget requirements, timing, and several other topics. We also talk about Steel City's marketing efforts. I asked several questions to James about the company's content strategy and how they try to stand out from competitors. James talks about the importance of sharing unique content and not falling into the trap of posting new branded merch items 24/7. We also talk about how Steel City has been testing new channels such as TikTok and whether this has been successful. The episode ends with some questions to James about his career and what he has learned along the way. I asked James what it was like to take over a family business and if he felt added pressure to succeed. To close out, James shares advice to other business owners and marketers based on what he has learned along the way.

Welcome to Episode 14 of the Global Drum Network podcast. This time we’re featuring our exclusive interview with the Funk-tastic PETE RAY BIGGIN, who has been tearing up stages all over Europe and beyond with the brilliant LEVEL 42, and driving his own project, the equally funky PB UNDERGROUND. With the latter outfit, Pete’s having to wear all the hats, from Songwriting to Producing and Arranging. It all makes the actual drumming part of day the most relaxing. Just as well he’s a bundle of energy! Anyway, his journey from Sheffield hopeful to driving along sell-out tours with the band he idolised as a kid is a fascinating one. Join us backstage in Bournemouth as he talks us through it all;Put your sticks down for a minute, take the weight off your feet and enjoy! Oh, and please be aware that if you're offended by swearing, Pete 'keeps it real' with his fruity expletives. In fact, you could say he's our sweariest guest to date!Anyway, if that hasn't put you off (and I hope it hasn’t), always remember; Whatever you play, Play it with passion!

Branded merchandise is one of the most effective ways of marketing any brand. Steel City is a leading producer of just about anything branded you can imagine. We met up with MD James Biggin to hear about their 40 years in business here in Sheffield. Find Steel City merch here: https://steel-city.co.uk/ (https://steel-city.co.uk/) Steel City Business is the Sheffield Business podcast, highlighting the great stuff happening within the business community here in Sheffield. Each episode features a company or organisation based in or around the city - from the big ones right down to the sole traders. If it’s happening in Sheffield, we’ll be covering it. It’s brought to you by the team at Rebel Base Media, the Sheffield-based podcasting experts.  Find out more at steelcitybusiness.com - and if you want to appear on Steel City Business or know someone we should feature email hellothere@rebelbasemedia.io

How do you do...or should we say how do you brew? You dynamic PNW coffee aficionados pick up right where they left off last episode from the history of coffee to the evolution of the types of machines to brew it. Join us with java on this second part of our "This Is Coffee" series. (Johnny Cash - A Cup of Coffee (https://www.youtube.com/watch?v=ktEkeJjHqBI). Complete with yodeling and either drunk or high rambling lyrics!)“Craft” CoffeeWater + Coffee +Time (and care) *how do you brew? aka Extraction Process** _*Pressure/Siphon*_ * Espresso * Percolator-later-early 19th century * Bialetti / siphon pot /(the Italian Moka pot (https://www.bialetti.it/it_it/company-story) which was invented in 1933.) * The earliest siphon pot (or vacuum brewer) dates back to the early 19th century. The initial patent dates from the 1830s in Berlin, but the first commercially available siphon pot was designed by Marie Fanny Amelne Massot, and it hit the market in the 1840s. By 1910, the pot made its way to America and was patented by two Massachusetts sisters, Bridges and Sutton. Their pyrex brewer was known as the “Silex.” * Moka pot (https://ineedcoffee.com/the-story-of-the-bialetti-moka-express/)": aluminum- the wonder metal (Facist drive to make it the national metal of Italy) stove-top brews coffee by passing boiling water pressurized by steam through ground coffee. Named after the Yemeni city of Mocha, it was invented by an Italian engineer named Alfonso *Bialetti* in 1933 * Aeropress (https://aeropress.com/why-aeropress/) * Alan Adler-designed instrumentation systems for military aircraft, nuclear reactors, and submarines, a paraboloid lens for telescopes, and dozens of flutes * 2004 Alan began studying the coffee brewing process and analyzing coffee maker designs - debuted 2005 * Low acid- 1/9 acid of french press, 1/5 of drip.* _*Gravity*_ * Drip * Pour over * Chemex (https://www.chemexcoffeemaker.com/) * (Family owned) The *Chemex* (https://www.chemexcoffeemaker.com/about-us) Coffeemaker was invented in 1941 by Dr. Peter Schlumbohm PhD. Made simply from non-porous, borosilicate glass and fastened with a wood collar and tie, it brews coffee without imparting any flavors of its own.--On permanent display at MOMA NY and other fine museums, it is truly a work of art.* _*Steep*_ * Ibirik * French press * The lore (https://europeancoffeetrip.com/the-history-of-french-press/): * A Frenchmen was boiling his water when he realised he had forgotten to put the coffee in. Once added, the coffee grounds rose to the surface of the boiling pot. He wanted to save the only portion of coffee he had with him and bought a piece of metal screen from a passing-by Italian merchant. Fitting the screen over the boiling pot, he used a stick to press the screen down, together with the coffee grounds. And how was the coffee? He expected it to be terrible, but the result turned out to be the best coffee both men had ever tasted. An accident led to a discovery of a new way of brewing coffee. * The first documented origins of the “most underrated method of brewing coffee”, as James Hoffmann called it in his book ‘The World Atlas of Coffee’, date back to 1852. It was Mayer and Delforge, two Frenchmen, who had their innovation—a simpler version of the later designs—patented then. * The coffee (https://en.wikipedia.org/wiki/Coffee) brewing device invented by Paolini Ugo and patented by Italian designer Attilio Calimani and Giulio Moneta in 1929.* _*Pod based brews*_ * Nespresso (https://www.nestle-nespresso.com/about-us/our-history)- began over 30 years ago “enable anyone to create the perfect cup of espresso coffee just like skilled baristas” * 1986 epicenter of this movement- introduced in Swiss households with the Turmix C100 machine and the Nespresso Club. Also got the eye of airlines * Keurig * The original single-serve brewer and coffee-pod manufacturing company, *Keurig*, Inc., was founded in Massachusetts in 1992. It launched its first brewers and *K*-*Cup pods* in 1998, targeting the office market. * 2004 was their boom*History* * https://www.thecoffeebrewers.com/hiofcobreq.html “Coffee drinking has always been somewhat of a social activity. Not surprisingly, as many women as men were involved in its evolution and the evolution of preparation techniques over the centuries. At one point, as for our own prohibition era, women tried to outlaw coffee. This was in 1674 in England. At that time, many women were angry because they felt that their men spent too much time in coffee houses drinking coffee and socializing.” * 17th century coffee cane and boomed in Europe. * “Historians believe the first coffee filter was a sock; people would pour hot water through a sock filled with coffee grounds. ”https://historycooperative.org/history-of-coffee-brewing/ * Mr. Biggin.” In 1780 “Biggin pots” coffee methods and hacks*Chris:*2. Turbocharged Caffeine hit? - Eat grapefruit along with your coffee. “By eating some grapefruit along with your morning coffee the caffeine from it stays in your bloodstream longer. ” From SpoonUniversity.com. (https://spoonuniversity.com/how-to/coffee-hacks-every-caffeine-addict-needs)3. Bitter Coffee Face? A study showed that sodium ions (https://www.independent.co.uk/life-style/food-and-drink/coffee-add-salt-not-sugar-better-flavour-taste-cup-caffeine-bitterness-sodium-a7675916.html), “...suppress the bitterness in coffee and actually enhance its flavor.“ While it shouldn’t be added to every cup of coffee, if its particularly bitter then a small pinch of salt will help to mellow the overall flavor.4. Make No-Churn Coffee Ice Cream (https://www.deathwishcoffee.com/blogs/news/7-coffee-hacks) - Add heavy cream, condensed milk, finely ground coffee, and warm water. Mix and freeze overnight. Top it with whipped cream because you deserve it. (From the Death Wish Coffee Company - best name for a coffee company according to Chris'.)5. Make ready-to-go coffee bags by scooping ground coffee in a coffee filter and tying it up. Put your DIY pouch in a cup of hot water and brew just as you would a cup of tea. From Better Homes and Gardens (https://www.bhg.com/recipes/drinks/coffee/5-simple-coffee-hacks-that-will-make-you-better-than-a-barista/).6. Make your own syrups - Vanilla Bean, Blackberry, Cinnamon Brown Sugar, and Almond (https://www.howsweeteats.com/2014/07/four-homemade-coffee-syrups-and-my-favorite-cold-brew/).7. Homemade Holidy Gift Idea (HHGI) - Create a DIY Coffee Candle - From PopSugar (https://www.popsugar.com/smart-living/Upcycled-Paper-Coffee-Cup-Candle-31102984) - (Small paper coffee cup, 1 to 2 tablespoons used coffee grounds, Paper towel, 1 cup wax candle remnants, Candle wick, Scissors, Small saucepan, Small metal or glass mixing bowl.)*AJ:*1. In Spokane? Want to learn and share int he passion of coffe- meet Indaba 1. https://www.indabacoffee.com (https://www.indabacoffee.com/)2. Coffee Honey- latte 3. Maple - latte 1. https://runamokmaple.com/ (RUNAMOK MAPLE, FAIRFAX, VERMONT (https://runamokmaple.com/contact/)) 2. https://www.woodinvillewhiskeyco.com/products/woodinville-barrel-aged-maple-syrup/ 4. Kamira 1. https://www.espressokamira.net/kamira?lang=en 2. Messina Sicily Italy Video in the intro and throughout the episode:*This is Coffee *by Vision Associates 1961 : Public Domain courtesy of the Internet Archive (https://archive.org/search.php?query=creator%3A%22Vision+Associates%22)Find us on the WebAJ: ajbarse.com (http://ajbarse.com/)Chris: chrispowell.co (http://chrispowell.co/)“Community-Powered KMRE, 102.3 FM airing our show Mondays @ 6:30 pm and Thursdays @ 6:00 pmand streaming worldwide at kmre.org” (http://kmre.org/)

How do you do...or should we say how do you brew? You dynamic PNW coffee aficionados pick up right where they left off last episode from the history of coffee to the evolution of the types of machines to brew it. Join us with java on this second part of our "This Is Coffee" series. (Johnny Cash - A Cup of Coffee (https://www.youtube.com/watch?v=ktEkeJjHqBI). Complete with yodeling and either drunk or high rambling lyrics!)“Craft” CoffeeWater + Coffee +Time (and care) *how do you brew? aka Extraction Process** _*Pressure/Siphon*_ * Espresso * Percolator-later-early 19th century * Bialetti / siphon pot /(the Italian Moka pot (https://www.bialetti.it/it_it/company-story) which was invented in 1933.) * The earliest siphon pot (or vacuum brewer) dates back to the early 19th century. The initial patent dates from the 1830s in Berlin, but the first commercially available siphon pot was designed by Marie Fanny Amelne Massot, and it hit the market in the 1840s. By 1910, the pot made its way to America and was patented by two Massachusetts sisters, Bridges and Sutton. Their pyrex brewer was known as the “Silex.” * Moka pot (https://ineedcoffee.com/the-story-of-the-bialetti-moka-express/)": aluminum- the wonder metal (Facist drive to make it the national metal of Italy) stove-top brews coffee by passing boiling water pressurized by steam through ground coffee. Named after the Yemeni city of Mocha, it was invented by an Italian engineer named Alfonso *Bialetti* in 1933 * Aeropress (https://aeropress.com/why-aeropress/) * Alan Adler-designed instrumentation systems for military aircraft, nuclear reactors, and submarines, a paraboloid lens for telescopes, and dozens of flutes * 2004 Alan began studying the coffee brewing process and analyzing coffee maker designs - debuted 2005 * Low acid- 1/9 acid of french press, 1/5 of drip.* _*Gravity*_ * Drip * Pour over * Chemex (https://www.chemexcoffeemaker.com/) * (Family owned) The *Chemex* (https://www.chemexcoffeemaker.com/about-us) Coffeemaker was invented in 1941 by Dr. Peter Schlumbohm PhD. Made simply from non-porous, borosilicate glass and fastened with a wood collar and tie, it brews coffee without imparting any flavors of its own.--On permanent display at MOMA NY and other fine museums, it is truly a work of art.* _*Steep*_ * Ibirik * French press * The lore (https://europeancoffeetrip.com/the-history-of-french-press/): * A Frenchmen was boiling his water when he realised he had forgotten to put the coffee in. Once added, the coffee grounds rose to the surface of the boiling pot. He wanted to save the only portion of coffee he had with him and bought a piece of metal screen from a passing-by Italian merchant. Fitting the screen over the boiling pot, he used a stick to press the screen down, together with the coffee grounds. And how was the coffee? He expected it to be terrible, but the result turned out to be the best coffee both men had ever tasted. An accident led to a discovery of a new way of brewing coffee. * The first documented origins of the “most underrated method of brewing coffee”, as James Hoffmann called it in his book ‘The World Atlas of Coffee’, date back to 1852. It was Mayer and Delforge, two Frenchmen, who had their innovation—a simpler version of the later designs—patented then. * The coffee (https://en.wikipedia.org/wiki/Coffee) brewing device invented by Paolini Ugo and patented by Italian designer Attilio Calimani and Giulio Moneta in 1929.* _*Pod based brews*_ * Nespresso (https://www.nestle-nespresso.com/about-us/our-history)- began over 30 years ago “enable anyone to create the perfect cup of espresso coffee just like skilled baristas” * 1986 epicenter of this movement- introduced in Swiss households with the Turmix C100 machine and the Nespresso Club. Also got the eye of airlines * Keurig * The original single-serve brewer and coffee-pod manufacturing company, *Keurig*, Inc., was founded in Massachusetts in 1992. It launched its first brewers and *K*-*Cup pods* in 1998, targeting the office market. * 2004 was their boom*History* * https://www.thecoffeebrewers.com/hiofcobreq.html “Coffee drinking has always been somewhat of a social activity. Not surprisingly, as many women as men were involved in its evolution and the evolution of preparation techniques over the centuries. At one point, as for our own prohibition era, women tried to outlaw coffee. This was in 1674 in England. At that time, many women were angry because they felt that their men spent too much time in coffee houses drinking coffee and socializing.” * 17th century coffee cane and boomed in Europe. * “Historians believe the first coffee filter was a sock; people would pour hot water through a sock filled with coffee grounds. ”https://historycooperative.org/history-of-coffee-brewing/ * Mr. Biggin.” In 1780 “Biggin pots” coffee methods and hacks*Chris:*2. Turbocharged Caffeine hit? - Eat grapefruit along with your coffee. “By eating some grapefruit along with your morning coffee the caffeine from it stays in your bloodstream longer. ” From SpoonUniversity.com. (https://spoonuniversity.com/how-to/coffee-hacks-every-caffeine-addict-needs)3. Bitter Coffee Face? A study showed that sodium ions (https://www.independent.co.uk/life-style/food-and-drink/coffee-add-salt-not-sugar-better-flavour-taste-cup-caffeine-bitterness-sodium-a7675916.html), “...suppress the bitterness in coffee and actually enhance its flavor.“ While it shouldn’t be added to every cup of coffee, if its particularly bitter then a small pinch of salt will help to mellow the overall flavor.4. Make No-Churn Coffee Ice Cream (https://www.deathwishcoffee.com/blogs/news/7-coffee-hacks) - Add heavy cream, condensed milk, finely ground coffee, and warm water. Mix and freeze overnight. Top it with whipped cream because you deserve it. (From the Death Wish Coffee Company - best name for a coffee company according to Chris'.)5. Make ready-to-go coffee bags by scooping ground coffee in a coffee filter and tying it up. Put your DIY pouch in a cup of hot water and brew just as you would a cup of tea. From Better Homes and Gardens (https://www.bhg.com/recipes/drinks/coffee/5-simple-coffee-hacks-that-will-make-you-better-than-a-barista/).6. Make your own syrups - Vanilla Bean, Blackberry, Cinnamon Brown Sugar, and Almond (https://www.howsweeteats.com/2014/07/four-homemade-coffee-syrups-and-my-favorite-cold-brew/).7. Homemade Holidy Gift Idea (HHGI) - Create a DIY Coffee Candle - From PopSugar (https://www.popsugar.com/smart-living/Upcycled-Paper-Coffee-Cup-Candle-31102984) - (Small paper coffee cup, 1 to 2 tablespoons used coffee grounds, Paper towel, 1 cup wax candle remnants, Candle wick, Scissors, Small saucepan, Small metal or glass mixing bowl.)*AJ:*1. In Spokane? Want to learn and share int he passion of coffe- meet Indaba 1. https://www.indabacoffee.com (https://www.indabacoffee.com/)2. Coffee Honey- latte 3. Maple - latte 1. https://runamokmaple.com/ (RUNAMOK MAPLE, FAIRFAX, VERMONT (https://runamokmaple.com/contact/)) 2. https://www.woodinvillewhiskeyco.com/products/woodinville-barrel-aged-maple-syrup/ 4. Kamira 1. https://www.espressokamira.net/kamira?lang=en 2. Messina Sicily Italy Video in the intro and throughout the episode:*This is Coffee *by Vision Associates 1961 : Public Domain courtesy of the Internet Archive (https://archive.org/search.php?query=creator%3A%22Vision+Associates%22)Find us on the WebAJ: ajbarse.com (http://ajbarse.com/)Chris: chrispowell.co (http://chrispowell.co/)“Community-Powered KMRE, 102.3 FM airing our show Mondays @ 6:30 pm and Thursdays @ 6:00 pmand streaming worldwide at kmre.org” (http://kmre.org/)

Nick and Alex are joined in the studio by drummer Pete Ray Biggin. See acast.com/privacy for privacy and opt-out information.

We recently heard from some of the season 1 Knife or Death contestants, and we agreed that it makes sense that some of these great competitors get the chance to tell their experiences with the Knife Fight and Dead Run courses in Season 1. Bladesmith Pat Biggin is first up, talking about his KoD run on Season 1, Episode 1 - The Last Samurai, his thoughts on Season 2, and going more in depth about his forging experience. Check him out here: IG: https://www.instagram.com/howling_wolf_knifeworks/ FB: https://www.facebook.com/howlingwolfknifeworks/ Also available on YouTube, just search for Fans of the Forge! SEND US A VOICE MESSAGE: https://anchor.fm/fans-of-the-forge/message Enter our 1000 Subscriber giveaway here: https://www.instagram.com/p/BwEpwq4hjUd/ Also available on YouTube, just search for Fans of the Forge! Our Social Media: Official Facebook: https://www.facebook.com/fansoftheforge/ Official Twitter: https://twitter.com/FansoftheForge Official Instagram: https://www.instagram.com/fansoftheforge/ --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Danelle Hunter is the Managing Director of Biggin & Scott Knox, an Award winning Property Manager and Real Estate Entrepreneur. Danelle is recognised as one of Melbourne’s most successful Property Managers and franchisees, having grown the business from two offices to four, increased revenue by 700% and doubled the rent roll, within just two years. Danelle has also developed her own Property Management training, ‘From PA to PM’, which has resulted in the property management department growing by 46.3% in just 12 months.

Discussing stranger things season 2. The Jets. March madness. And two hilarious stories including Dogging and a man just wanting to hang with the Bros --- Support this podcast: https://anchor.fm/kip-sodope-wood/support

With guest SnakeFPV and Toby SnakeFPV https://www.youtube.com/channel/UC2lMtWiCL2Xz59rQGbIcTVw   Stay tuned for the new stuff, join the mailing list!! https://www.ethixltd.com/ -Steele -Eric -Ruben   Website www.TeamFailSafe.com Instagram https://www.instagram.com/teamfailsafe/?hl=en Facebook https://www.facebook.com/TeamFailsafeofficial/ Host https://www.facebook.com/MrSteeleFPV https://www.youtube.com/user/MrSteeledavis Host https://www.facebook.com/konastyfpv/ https://www.youtube.com/channel/UCT-U9XQDwnKKCqzEQC7AgOg Host https://www.facebook.com/ruben.jauregui.351 https://www.youtube.com/user/TheJclone   Youtube Comming soon #teamfailsafe

Physiotherapy and acupuncture are commonly recommended for those living with chronic pain, however these therapies can often be costly and are not accessible to all.Naomi Biggin-Pound (physiotherapist, women's health physiotherapist, acupuncturist, and rehabilitation pilates instructor) has helped to bridge this gap through her FREE self-guided exercise programs for people living with chronic back, knee and pelvic pain. These video series are based on a combination of pain science, physiotherapy, as well as practices of mindfulness, spirituality and empathy. In this episode, Naomi talks about the value of movement in managing pain and how to incorporate practices of mindfulness and empathy to increase function.To access her free programs, please visit www.selftreatmentandexercise.com.

Hey everyone! Ep 2 finally exists and is available. Welcome….to our horrible outside recording wherein we discuss the cinematography of The Thing, Big Dogs shirts and the ideological void behind them, and the need of many dudes to harass strangers to feel good! Please enjoy. If you have a suggestion or a question, email us… Continue reading SASSY BOYS #2: BIGGIN’ UP THE DOGS →

In this episode of the Distillery Nation Podcast we talk to Ben Capdevielle from Captive Spirits and the creator of Big Gin. Ben talks about starting small, his tips on making the most of the distillery space and his favorite drink! Please visit this podcast at http://www.mastrogiannisdistillery.com/ and view all of today's show notes. Today's music was Balkans Beats by The Freak Fandango Orchestra.

Join us as we divulge more info on VaperSlam, break down Bill Cosby's debaucle, hear from Biggin; a family member of Mini Junior and Junior, break down some questions, read you really awful Facebook status' and much more on this episode of Totally Vaping Awesome.

In which we talk planes, Michael Jackson, RSI, the shooting at Harry Morgan's restaurant in St Johns Wood, & how Microsoft are going to price Windows 7

Poet, translator and performer Rab Wilson (Sanquhar, Dumfriesshire), reads from his latest collection in Scots and English. Works include his Scots translation of The Ruba’iyat of Omar Khayyam and parliamentary poems commissioned for MSP Cathie Jamieson. about Rab Wilson listen (2MB) For a hifi version of this MP3, go here.Poems:BigginThe Last Sea-EagleDumfounert Wi WunnerAccent O The Mind