Podcasts about Markov

This week, Oleg Markov reflects on his unlikely AFL journey. From growing up involved in athletics, to his stints at Richmond, Gold Coast and Collingwood, Leggy opens up about the highs and lows that shaped his career.He shares the disappointment of being delisted, the call from Craig McRae that revived his career, and what it felt like to become a premiership player in 2023. Plus, we dive into the mind of one of footy's great characters.The BackChat Podcast is served by Liquor Barons. Let your thirst for discovery be guided by Liquor Barons - find your nearest store!The BackChat Podcast is recorded out of BC Studios, built by grounded. building tomorrow, together.Thanks to our additional sponsors:TABtouch - Don't gamble more than you can afford to lose. Call Gambling Help WA (08) 9325 6644 enquiries@centrecare.com.au or Gambling Help on 1800 858 858 or https://www.gamblinghelponline.org.au/Mamba Digital - E-Commerce & Digital MarketingCamera Electronic - A wide range of premium photographic equipment and knowledge.SAY HELLOEmail: hello@backchatpodcast.com.auSocials: @backchat__Web: www.backchatpodcast.com.au Hosted on Acast. See acast.com/privacy for more information.

There's more than a few photos kicking around of Brendan Gallagher, Andrei Markov and Tomas Plekanec all together on the Habs. They were all on the team from 2012 when Gallagher got called up to Markov's departure at the end of the 2016-2017 season. All three of those guys played over 900 games for the bleu-blanc-rouge. I feel like only Markov has a real chance of having his number up in the rafters and even then I wouldn't consider it a lock. All the same Brendan Gallagher is certainly a player who I think most Habs fans will remember fondly for a very long time. Pretty sure it's the right time to move on, the team is younger and poor Gally is just not going to be a part of whatever the final form of this roster looks like. Still I can be a little sad about a guy who has often been described as “the heart and soul” of the team no longer wearing the CH. Plus during the pandemic he did some genuinely funny tiktok videos. Even if they're just lip-synching to scenes from TV shows that's still more personally than we see from 99% of hockey players. He posted one when they were going into the weird hockey bubble set to the Hunger Games theme song that I can't find and that was extremely funny. Anyways, apparently screw worms are coming to America this summer. I guess look it up on the internet if you want to get extra grossed out. Scott and Jon both watched Ron Howard's 2015 movie about Moby Dick In The Heart of the Sea and it seemed that they both were pretty mixed on the whole thing. Finally, Scott still really, really hates Andor. You'd think it starred Matt Damon or something. Over on Garbage Time we talk about how crazy it is that Marvel and DC still work month to month and pay artists and writers by the page when they're now controlled by monstrous entities like Disney and Warner Bros. We then discover that there is SO MUCH MORE Walking Dead than you think there is. If you would like to show your support and head over to Patreon and subscribe at the 9ES Deluxe tier to listen to this and all past episodes of Garbage Time that would be appreciated. Credit Where Credit is Due Our intro song is a brand new jam cooked up by OKU-DA just for us, do yourself a favour and check out his SoundCloud). The post 9ES364: Beef Producers appeared first on 9to5 (dot cc).

There's more than a few photos kicking around of Brendan Gallagher, Andrei Markov and Tomas Plekanec all together on the Habs. They were all on the team from 2012 when Gallagher got called up to Markov's departure at the end[…]↓ Read the rest of this entry... The post 9ES364: Beef Producers appeared first on 9to5 (dot cc).

Welcome to Impact Theory with Tom Bilyeu. In today's mind-bending episode, Tom sits down with cognitive scientist Donald Hoffman, who challenges everything you think you know about reality, consciousness, and the very fabric of our universe. What if the world around us isn't the fundamental base of existence, but rather, nothing more than a meticulously rendered simulation—an efficient computational interface, like a high-tech headset, designed to help us survive, not reveal the truth?Together, Tom and Donald dive deep into groundbreaking theories emerging from the frontlines of quantum physics and mathematics, including “positive geometries” and the idea that spacetime is not fundamental. They break down complex scientific concepts—like Markov chains and the hard problem of consciousness—into compelling metaphors drawn from video games, virtual reality, and computation.Throughout the conversation, they grapple with the illusion of free will, the meaning of “base reality,” and whether consciousness is ultimately all there is—hinting at a future where understanding the software outside the headset could make today's technology look like child's play. Whether you're a skeptic, a seeker, or just driven by unending curiosity, you're in for an episode that could forever shift your perception of what it means to be real. What's up, everybody? It's Tom Bilyeu here: If you want my help... STARTING a business: join me here at ZERO TO FOUNDER:  https://tombilyeu.com/zero-to-founder?utm_campaign=Podcast%20Offer&utm_source=podca[%E2%80%A6]d%20end%20of%20show&utm_content=podcast%20ad%20end%20of%20show SCALING a business: see if you qualify here.:  https://tombilyeu.com/call Get my battle-tested strategies and insights delivered weekly to your inbox: sign up here.: https://tombilyeu.com/ ********************************************************************** If you're serious about leveling up your life, I urge you to check out my new podcast, Tom Bilyeu's Mindset Playbook —a goldmine of my most impactful episodes on mindset, business, and health. Trust me, your future self will thank you. ********************************************************************** FOLLOW TOM: Instagram: https://www.instagram.com/tombilyeu/ Tik Tok: https://www.tiktok.com/@tombilyeu?lang=en Twitter: https://twitter.com/tombilyeu YouTube: https://www.youtube.com/@TomBilyeu Ketone IQ: Visit https://ketone.com/IMPACT for 30% OFF your subscription orderQuince: Free shipping and 365-day returns at https://quince.com/impactpodMonetary Metals: Future-proof your wealth at https://monetarymetals.com/impactTruemed: Check your eligibility and start saving at https://truemed.com/impactAT&T Business: Switch to AT&T Business at business.att.comIncogni: Take your personal data back with Incogni! Use code IMPACT at the link below and get 60% off an annual plan: https://incogni.com/impactShopify: Sign up for your one-dollar-per-month trial period at https://shopify.com/impactNetsuite: Right now, get our free business guide, Demystifying AI, at https://NetSuite.com/TheoryQuo: Try for free PLUS get 20% off your first 6 months at https://quo.com/impact Learn more about your ad choices. Visit megaphone.fm/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome to Impact Theory with Tom Bilyeu. In today's mind-bending episode, Tom sits down with cognitive scientist Donald Hoffman, who challenges everything you think you know about reality, consciousness, and the very fabric of our universe. What if the world around us isn't the fundamental base of existence, but rather, nothing more than a meticulously rendered simulation—an efficient computational interface, like a high-tech headset, designed to help us survive, not reveal the truth?Together, Tom and Donald dive deep into groundbreaking theories emerging from the frontlines of quantum physics and mathematics, including “positive geometries” and the idea that spacetime is not fundamental. They break down complex scientific concepts—like Markov chains and the hard problem of consciousness—into compelling metaphors drawn from video games, virtual reality, and computation.Throughout the conversation, they grapple with the illusion of free will, the meaning of “base reality,” and whether consciousness is ultimately all there is—hinting at a future where understanding the software outside the headset could make today's technology look like child's play. Whether you're a skeptic, a seeker, or just driven by unending curiosity, you're in for an episode that could forever shift your perception of what it means to be real. What's up, everybody? It's Tom Bilyeu here: If you want my help... STARTING a business: join me here at ZERO TO FOUNDER:  https://tombilyeu.com/zero-to-founder?utm_campaign=Podcast%20Offer&utm_source=podca[%E2%80%A6]d%20end%20of%20show&utm_content=podcast%20ad%20end%20of%20show SCALING a business: see if you qualify here.:  https://tombilyeu.com/call Get my battle-tested strategies and insights delivered weekly to your inbox: sign up here.: https://tombilyeu.com/ ********************************************************************** If you're serious about leveling up your life, I urge you to check out my new podcast, Tom Bilyeu's Mindset Playbook —a goldmine of my most impactful episodes on mindset, business, and health. Trust me, your future self will thank you. ********************************************************************** FOLLOW TOM: Instagram: https://www.instagram.com/tombilyeu/ Tik Tok: https://www.tiktok.com/@tombilyeu?lang=en Twitter: https://twitter.com/tombilyeu YouTube: https://www.youtube.com/@TomBilyeu Ketone IQ: Visit https://ketone.com/IMPACT for 30% OFF your subscription orderQuince: Free shipping and 365-day returns at https://quince.com/impactpodMonetary Metals: Future-proof your wealth at https://monetarymetals.com/impactTruemed: Check your eligibility and start saving at https://truemed.com/impactAT&T Business: Switch to AT&T Business at business.att.comIncogni: Take your personal data back with Incogni! Use code IMPACT at the link below and get 60% off an annual plan: https://incogni.com/impactShopify: Sign up for your one-dollar-per-month trial period at https://shopify.com/impactNetsuite: Right now, get our free business guide, Demystifying AI, at https://NetSuite.com/TheoryQuo: Try for free PLUS get 20% off your first 6 months at https://quo.com/impact Learn more about your ad choices. Visit megaphone.fm/adchoices

Uma Cadeia de Markov é um modelo estocástico (probabilístico) que descreve uma sequência de eventos onde a probabilidade do próximo estado depende apenas do estado atual, e não do histórico passado. Conhecida pela propriedade de "falta de memória", é usada para prever sistemas que evoluem no tempo.

English Edition: In a follow up about "unusual" computers I want to focus on field programmable gate arrays - FPGAs. With my guest and former colleague at UCL, Michael McLeod, we talk about what they are, where they are used and what's so special about working with them.Links:https://www.ibm.com/think/topics/field-programmable-gate-arrays https://en.wikipedia.org/wiki/Field-programmable_gate_array https://fpga.epcc.ed.ac.uk https://en.wikipedia.org/wiki/Hardware_description_language https://nandland.com/the-go-board/ the Go Board affordable FPGA for testing and learninghttps://nandland.com/ Nandland have more resources on FPGAhttps://en.wikipedia.org/wiki/Xilinxhttps://web.archive.org/web/20070412183416/http://filebox.vt.edu/users/tmagin/history.htmhttps://www.amd.com/en/products/adaptive-socs-and-fpgas/fpga.html https://space.pitt.edu/sites/default/files/2024-10/FPL_13_B112a.pdf Paper discussing a use case of hardware preservation with FPGAshttps://people.inf.ethz.ch/wirth/FPGA-relatedWork/RISC.pdf Niklaus Wirth, the creator of the Pascal language, did some work with FPGA as wellhttps://en.wikipedia.org/wiki/Markov_decision_process Markov decision processhttps://en.wikipedia.org/wiki/Markov_chain Get in touchThank you for listening! Merci de votre écoute! Vielen Dank für´s Zuhören!Contact Details/ Coordonnées / Kontakt:Email mailto:peter@code4thought.orgUK RSE Slack (ukrse.slack.com): @code4thought or @piddie Bluesky: https://bsky.app/profile/code4thought.bsky.socialLinkedIn: https://www.linkedin.com/in/pweschmidt/  (personal Profile)LinkedIn: https://www.linkedin.com/company/codeforthought/ (Code for Thought Profile)This podcast is licensed under the Creative Commons Licence:  https://creativecommons.org/licenses/by-sa/4.0/

Hello Interactors,It's been a while. Traveling for family, and a bit flooded by the relentless sneaker waves of unsavory world events — the kind that usually inspire me to write but lately threaten to pull me under.Spring in the northern hemisphere means Interplace turns to geographic information science and spatial analysis. How might we look at the complex unfolding of world events through this lens — and what happens when we push it further than emergence alone can carry it? That's what I attempt to explore here.PATTERNS PRECEDING PHYSICAL PLACESGeographic information science is a relatively recent field. It emerged from mid-20th-century cartography and land-use planning. Computer cartography and quantitative geography of the 1960s is often considered the first true digital Geographic Information Systems (GIS). It became a science (GIScience or GISc) in the late 1980s and early 1990s when Michael Goodchild questioned if there was a genuine scientific discipline lurking within the software.His answer was yes. He built an institutional home for that argument at the National Center for Geographic Information and Analysis at the University of California, Santa Barbara, my alma mater. Goodchild was my senior advisor in 1989 as UCSB was becoming a generative intellectual hub in the field. UCSB's geography department continues to push the question of what space means analytically, not just how to map it. I'm personally invested in better understanding how GISc may be a natural partner for complexity science, a field I've been attracted to since I started researching and writing.This partnership isn't new. GISc provides a powerful framework for dissecting the spatial dimensions of complexity, where systems defy reductionist analysis and emerge through nonlinear interactions. In the early 2000s, geographer David O'Sullivan, and others, articulated this as the study of “the behaviour of macroscopic collections of many basic but interacting units endowed with the potential to evolve in time” emphasizing these characteristic elements of complexity science: self-organization, path dependence, and the irreducibility of wholes to their parts. Around the same time, sociologist John Urry (and others) extended this to global scales, portraying globalization as co-evolving systems marked by unpredictability, irreversibility, and positive feedback loops that amplify disorder within pockets of order.These parings are a good start, but computational biologist Michael Levin offers what can be seen as a genuinely unsettling upgrade. His recent work on the origin of cognitive and morphological patterns suggests the dominant appeal to emergence as an explanatory endpoint may itself be, in his words, a “mysterian” position — one that “does not facilitate further advances.” When a surprising pattern appears in a complex system, the emergentist says “that's just what happens” and catalogs it.But Levin proposes these patterns are not random facts to be noted and admired. They are part of an ordered, non-physical space that physical systems, when configured the right way, ingress into. Ingression is a term Levin borrows from mathematician Alfred North Whitehead as a potential that timeless abstract objects possess to become actual concrete experiences. “Red” only becomes red when its potential is realized. These ‘ordered spaces' of potential are portals into what Levin calls a Platonic Space. Plato argued that the objects we encounter in the world are imperfect instances of perfect, eternal Forms that exist independently of any physical thing. The most primitive form being the triangle. Levin's argument is the triangle participates in a kind of Triangleness; it realizes it's potential to exist.Nature keeps arriving at triangles independently, across wildly different substrates, as if drawn by the same attractor. The triangle is the only polygon that is inherently rigid: push on any corner and the shape holds, which is why trusses, bridges, and bones all rely on triangular geometry for structural strength. Radiolarians, single-celled ocean organisms with no brain and no blueprint, construct intricate skeletal lattices of triangulated geometry at microscopic scales.In Levin's terms, nature is ingressing Triangleness — repeatedly, across billions of years and countless lineages — because the Form has properties that reward any physical system stable enough to express it. The truth that a triangle's angles sum to exactly 180 degrees owed nothing to the first organism that built one.Physical systems are, in this sense, less like containers and more like pointers — a term borrowed from computer science. Pointers are variables that hold the addresses that reference more information. Levin's framework requires a specific kind of pointer: not a pointer to stored data, which retrieves a static value, but a pointer to a subroutine that calls up a routine that executes complex actions and outputs beyond the pointer itself. The pointer is small, while the executed routine may be vast and behave unpredictably.Think of a street address. The address itself contains nothing — it is a short string of numbers and words that fits on an envelope — but hand it to the right system and it retrieves a house, a history, a neighborhood, everything that has ever happened inside those walls. This is Levin's claim about physical structures. A genome, a city, an institution doesn't contain its pattern so much as it points at one — and when the pointer is well-formed, you get considerably more out than you put in.What does this mean for GISc? It means that spatial configurations — cities, borders, trade corridors, migration routes — are not merely sites where local interactions produce global outcomes. They are interfaces into a latent pattern space. When a hub city emerges, when a colonial border persists for centuries past the empire that drew it, when a pandemic spreads exactly along the topology of air travel, we are not only witnessing the consequential mechanical emergence of patterns derived from local rules. We are watching physical structures act as pointers that summon — ingress — specific patterns of collective behavior, whose full complexity exceeds what was put in. Levin's core observation about biological morphogenesis translates here with uncomfortable precision.Consider one of his more unsettling tadpole experiments. The creation of its normal bulging eyes are suppressed (by microscopically manipulating cellular ‘software') and a replacement eye is instead induced — ingressed — on the tail. The optic nerve growing from that tail-eye doesn't connect to the brain — it terminates somewhere around the spinal cord. By any conventional account, the animal should be blind. It isn't. The tadpoles can still see and perform well in visual tasks. Somehow, the system routes around its own abnormal wiring to recover function. The pattern being pointed to — sight — was never housed in the eye itself, or in the specific neural pathway, or in any single component. The eye on the tail is a wildly improbable pointer, and yet it retrieves something far richer than its own structure contains. You get considerably more out than you put in.Some GISc tools — like agent-based models or network analysis — already detect this excess in a geography context. A single infected traveler tips a system toward chaos not because of arithmetic addition of local interactions described in the GISc analysis, but because that traveler's position in a network acts as an interface to a pattern of contagion whose scope was latent in the structure all along. The “geographic advantage” O'Sullivan, and crew, describes — GISc's relationship to multi-scalar processes and human-environment couplings — is, in Levin's vocabulary, a sensitivity to how physical arrangements act as pointers into a rich space of possible collective behaviors.This reframes world events not as linear narratives but as navigations of morphospace — the full landscape of forms a system could take, where some configurations are reachable and others are not, and where attractors pull trajectories toward specific patterns regardless of starting conditions.What pattern are current geopolitical configurations pointing toward? What is being ingressed by the particular architecture of today's global institutions, communication networks, and urban densities? While GIScience sharpens our sight on outcomes, it leaves uncharted the deeper question of what is the shape of the latent space these material forms slip into.BORDERS STORE WHAT BODIES KNOWLevin's work suggests at every scale of organization, we are dealing not with mechanical aggregation but with collective intelligence. To understand what he means by that, it helps to borrow an image from Einstein.Because nothing travels faster than light, any event you could possibly influence — or that could possibly influence you — is bounded by how far light could travel in the available time. Draw that boundary in spacetime and it forms a cone. Everything inside it is causally reachable, everything outside it is not. Levin borrows this image to describe the reach of any cognitive agent. A single cell's light cone is tiny — it can only sense and respond within its immediate chemical neighborhood, over milliseconds. A brain's light cone is vastly larger — it can model consequences years out and coordinate behavior across great distances. The cone is simply a measure of how far an agent's agency actually extends. And just as the body is a nested hierarchy of such agents — molecular networks, cells, tissues, organs — each operating within its own cone, pursuing goals whose scale its parts cannot perceive, so too is human society.A city is not simply a dense clustering of individuals whose local interactions produce urban dynamics. It is, in Levin's sense, a collective intelligence with a cognitive light cone that vastly exceeds that of any constituent. It pursues goals (economic growth, defense, habitability) across spatial and temporal horizons no individual cell — or individual person — can access. Institutions, legal codes, infrastructure, and cultural norms function as bioelectric memory — rewritable pattern memories that store the target morphology of the social body and guide error-correction toward it. Colonial borders, or the Great Wall of China, persist not merely through inertia but because they function like historic bioelectric setpoints. That is, they encode a spatial pattern that downstream processes continuously re-instantiate, even after the circumstances that produced them have dissolved.Levin's planarian flatworm experiments demonstrate this in biology. When bioelectric circuits are disrupted, the worm grows heads of other species — without any change to its genome. The pattern being expressed was latent in the space of possible forms, and a change in the interface (the bioelectric circuit) changed which pattern was ingressed. Geopolitical history offers analogies. How much of what we call a nation-state's “character” is not in its people but in the pattern stored in its institutional circuitry? When those circuits are disrupted — by revolution, invasion, or collapse — new patterns rush in from the adjacent possible, sometimes from regions of the latent space that are recognizable, sometimes shockingly novel.Pandemics also embody this scalar nesting. Viral replication is a molecular-scale process; its spread is topologically determined by the network of global mobility; its political consequences are mediated by institutional pattern memories about sovereignty, solidarity, and resource allocation. The COVID-19 pandemic did not merely “emerge” — it ingressed a set of patterns whose latency was already encoded in the physical architecture of 21st-century globalization. Competitive resource hoarding and cooperative vaccine-sharing were not just policy choices but different attractors in a landscape of a kind of “social morphospace”, pulling collective behavior toward different setpoints.GISc tools (like spatial game theory and network percolation models) map the surface of these landscapes. But Levin's framework asks us to go further. He wants us to not just map the attractors, but to ask what structured space those attractors are features of, and whether that space can be systematically explored.The scalar interplay extends outward. Local ethnic tensions, mapped via GIS hot-spot analysis, interact with what social theorist Zygmunt Bauman might term “global fluids” — arms, money, diasporas — to produce cascades that reflect not random chaos but path-dependent trajectories through a space of historical patterns. History's “nightmare on the brain of the living” becomes, in Levin's terms, a pattern-memory etched into the social substrate. Territorial borders, attempted genocide, human displacement are held as bioelectric setpoints, where trauma lingers as a morphogenetic field, quietly organizing the tissue of the present long after the original wound.MAPPING WHAT MATTER MERELY MISSESComplexity science, via GISc, forecasts world events as probabilistic landscapes rather than deterministic paths. Urry describes global systems as “adapting and co-evolving,” with attractors drawing trajectories amid chaos. GISc simulates this through fitness landscapes like agents navigate peaks and valleys of viability, local adaptations generating global patterns like economic booms or institutional collapses.Levin's framework intensifies this picture in two ways. First, it insists that the attractors are not randomly distributed. The latent space of possible social patterns — like the latent space of morphogenetic outcomes — has structure. Evolution, as Levin argues, progresses rapidly precisely because the space has “a relatively smooth character” in which “past interactions with it carry non-trivial information about the adjacent possible.” The same may be true of cultural and institutional evolution. The reason certain forms of governance, urbanism, or economic organization recur across independent civilizations is not purely because of convergent environmental pressures, but because they represent attractors in a structured space of collective intelligence patterns that sufficiently complex social interfaces tend to ingress.Second, and more provocatively, Levin's framework suggests that we do not simply make the social forms we inhabit. We invite patterns to temporarily inhabit our collective embodiments. To see why, consider one of his most uncontroversial and disarming experiments. Levin's lab studied simple sorting algorithms — the kind computer science students have used for decades. These are short deterministic procedures that take a jumbled list of numbers and rearrange them into sequential order. Nothing mysterious here but made for many an interview question at Microsoft!When Levin's team visualized the algorithm's progress as a movement through an abstract sorting space, unexpected behaviors emerged that nobody had noticed in all those decades of use. When the algorithm encountered a number that refused to move — a piece of broken data blocking its path — it didn't simply halt. It temporarily de-sorted the rest of the array, moved things around the obstruction, and then recovered its progress. It was exhibiting something resembling delayed gratification — the capacity to temporarily move away from a goal in order to reach it more completely later. Like a soccer player kicking the ball backwards to advance it forward.This ability was not written into the algorithm. Nobody put it there. Then, when the team ran a distributed version where each number ran its own variant of the algorithm, numbers sharing the same variant spontaneously clustered together — a kind of social behavior, emerging without a single line of code instructing any number to notice or prefer its own kind. The algorithm was doing something it was never designed to do, and had been doing it, unobserved, for decades.Now, imagine a democracy is not constructed from scratch by rational agents but an interface that, when configured appropriately, ingresses a pattern of distributed decision-making whose properties exceed what any designer or participant imagined or specified. Cities, constitutions, and international institutions become pointers. The patterns they summon may even surprise their architects — and may have been quietly surprising them and us all along.This has immediate consequences for how GISc could approach attempts at predicting futures. For example, prospective spatial modeling — Markov chains, scenario planning — maps the probability surface of possible trajectories. But a Levin-inflected GISc would ask this: what new pointers are being constructed right now, and what regions of the latent pattern space are they configured to access?The answers could become bewildering in a world of AI-mediated governance, hybrid human-machine urban systems, and the synthetic biological constructions Levin's team pursues. These are vehicles of exploration into regions of Platonic space we have not navigated before. “We are now fishing in regions of Platonic space we have never explored before,” he writes — with implications not only practical (”what will it do to us”) but ethical (”how do we fulfill the opportunities and duties of an ethical synthbiosis with beings who are not quite like us”).For GISc, this need not be merely philosophical. Spatial planning and governance literally configure the physical interfaces through which collective intelligence patterns are ingressed. Urban density fosters certain attractors of solidarity and innovation while sprawl ingresses different ones. Green civic infrastructure designed to buffer floods mechanically also reconfigures the relationship between human settlement and ecological pattern space which invites a whole different class of emergent resilience. The question is no longer only “what will happen here, probabilistically” but “what are we building a pointer toward?”Fatalists may see the latent space as already barring our options. Pessimists will amplify the risks of novel pointers we cannot control. Realists might attempt to quantify via more Monte Carlo simulations. And techo-optimists may try to engineer and configure interfaces to access and profit from whatever attractors emerge. But what I like most of all about Levin's framework is that it offers something more nuanced than any of these: structured humility. We do not know the full topology of the space we are pointing into. Every new city, every new institution, every new technological architecture is, in some sense, a bioengineering experiment — and like Levin's Xenobots and Anthrobots, it may manifest competencies and patterns nobody designed or predicted.If Levin's intuition is correct, we are but temporary self-organizing forms that hold together for a time, perform actions that exceed their physical composition, and then yield to the impermanence built into any pointer's relationship with the patterns it accesses. Humility does feel like the appropriate response. But more importantly, the recognition that mapping the structure of the space we are ingressing into is, at this moment, among the most important things we could do.The information embedded in Geographic Information Science has the potential to demystify fatalism, especially when death's certainty yields to spatial agency. Levin reminds us that information, at its Latin root, means to give form — to in-form. That is what geographic information has always done, long before it became a science. It did not merely transmit data, but impose structure on space, render the implicit geometry of human existence legible and actionable. Every map is an act of in-forming. The world is no doomsday script, but a co-evolving field — its attractors mappable, its interfaces legible, its vectors steerable — if we aim with care, with intent, and with the humility to know what we summon may exceed what we design.REFERENCESLevin, M. (2025). Ingressing minds: Causal patterns beyond genetics and environment in natural, synthetic, and hybrid embodiments. PsyArXiv. O'Sullivan, D., Manson, S. M., Messina, J. P., & Crawford, T. W. (2006). Space, place, and complexity science. Environment and Planning A: Economy and Space.Urry, J. (2003). Global complexity. Polity Press. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit interplace.io

V sobotnem popoldnevu je bila naša gostja s. Metka Tušar, ki se je rodila v Šempetru pri Novi Gorici, otroštvo pa preživela v Šebreljah, sredi Idrijsko-Cerkljanskega hribovja. Kot devetnajstletna je vstopila k usmiljenkam in kot medicinska sestra delala v različnih bolnišnicah po Sloveniji. Trenutno je zaposlena v domu starejših: Domu svete Katarine v Mengšu kot glavna medicinska sestra. V oddaji jo bomo gostili tudi kot pesnico in pisateljico; poezijo piše že od srednje šole in lani je izdala pesniško zbirko Svobodni, tri leta prej pa pesmi in pravljice Ti boš povedal. V pogovoru tudi o njeni preizkušnji – možganskem raku in spoznanjih, ki ji jih je ta prinesla v njeno življenje. V času po zdravljenju je prepisala celotno Novo zavezo Svetega pisma, Markov evangelij pa še s kaligrafsko pisavo. Navdih in odmik išče v naravi, ki jo rada tudi fotografira, fotografije pa tudi umestila v svoji pesniški zbirki.

Radka Matesová Marková je šéfredaktorkou zpravodajství ČTK, a zároveň první ženou na této pozici v historii agentury. V ČTK působí od roku 1997, psala o armádě, zahraničí i  sportu, a je držitelkou Novinářské křepelky.V nové epizodě Celetné On Air se Aneta Benešová a Jenda Novotný bavili s Radkou Matesovou Markovou:O ženách a médiích a o tom, proč jich je v šéfredaktorských křeslech stále tak málo, jestli za tím stojí jen sebevědomí nebo něco hlubšího, a co si Marková myslí o kvótách.O životě ve zpravodajství, jak vypadá den, kdy musíte vyprodukovat stovky zpráv, jak se nestát obětí vyhoření a co obnáší ona pověstná "ČTK diagnóza".A o Filmové škole v Uherském Hradišti, kde ČTK působí jako významný mediální partner.To i mnohem více se dozvíte při poslechu této epizody.

Lords: Chris Fabian https://fgiesen.wordpress.com/ Topics: Oops, my 3D printer became a hobby GTA's AI is not trying to screw with you with its sudden lane changes and T-boning you at intersections, it's just oblivious. (Probably.) Esper says: "I can confirm the traffic AI in Cyberpunk 2077 is still hilarious. I set my car to 'auto drive' and after maybe 30 seconds it took a hard right into the ocean. Maybe that's lore accurate, who knows." Alberic Whale and the Enigma Layer https://thespinoff.co.nz/the-best-of/31-12-2018/summer-reissue-the-mystery-of-zach-new-zealands-all-too-miraculous-medical-ai https://thespinoff.co.nz/society/13-01-2020/rip-zach-probe-finds-serious-wrongdoing-over-miracle-medical-ai Between What I See and What I Say…, by Octavio Paz https://www.wisdomportal.com/PoetryAnthology/OctavioPaz-Anthology.html Microtopics: A coffee shop that exists here because of the port of Oakland. Popping unroasted coffee beans into your mouth like peanuts. The worst tasting and most caffeinated cup of coffee you've ever had. Your local library. Things that should not be businesses. Three possible purposes of universities. Finding a new hobby (derogatory) 3D printing a selection of action figures for your wedding. That one person you know who's really into 3D printers. Why having a broken 3D printer counts as a hobby where having a broken refrigerator is just a situation. Yanking out some gunk with pliers in hopes that that'll fix it. Your 3D printer breaking halfway through your wedding figurine project so you have to make the other other half out of milled aluminum. IBM Selectric Typewriters shipping with a repair guy who lives in your spare bedroom in case it breaks. Amazon sending an Amazon warrior to repair your 3D printer but since you only paid for the cheap extended warranty she's allowed to attack anybody including you. Whether Balatro is trying to deliberately find weaknesses in your build. Higher fidelity graphics coming with expectations of higher fidelity traffic modeling. Car AI in open world games being as dumb as the developers can get away with, except for in Cyberpunk 2077, where they're dumber than the developers can get away with. Whacking at it until it's good enough to ship. Traffic tuning in GTA Vice City. Playing games with really smart, effective AI, like Chessmaster 2000 and X-Com, and realizing that actually having really smart AI is no fun. Skating around with rollerblades on your elbows and knees. Everything's a tuna can. Three car accidents in six weeks. Conscientiously objecting to military service so they insist you get a driver's license instead. Driving through a haunted house to train the braking reflex in response to being startled. Whatever happened to ol' Alby Whale? The AI assistant named Zack turning out to just be a dude named Zack. Adorable tiny food delivery robots who turn out to just be remote controlled by a guy hiding around the corner. Waymo cars blocking major thoroughfares for hours at a time. Multitasking between all the most stressful, confusing driving situations. Self-driving cars (allegedly) turning self-driving off half a second before impact so the impact is blamed on the human operator. Several hundred tons of liquid nitrogen cooled supercomputer. Blaming your spelling errors on The Enigma Layer. Having seen more proof of your AI assistant than you have of god. It's scammers and hucksters all the way down. Whether DLSS is taking away game developer jobs. What happens when you go from a three word Markov model to a five word markov model. A giant prank with no particular end-game in sight. Acts of speech. Poetry as synesthesia. Trying to explain in words why that cat is acting weird when the cat doesn't think in words at all. My Psychosis, my Bicycle and I, by Fritz B. Simon. Trying to figure out how football works when you can't see the players, only the referee. Feeling some type of way. Trying to take musical ideas and apply them outside of the realm of music. Creating words that dance around concepts. Getting stuck forever in your cringe phase. Opportunities to write the same program over and over again. A melancholy linked list implementation. Passive-aggressive C code. Java Enterprise Abstract Singleton Proxy Factory Bean. Remember printed manuals? The international obfuscated C code contest. What made the 3D accelerated demo scene interesting again. How much code you can fit in 64k if you don't link to anything. Secret Topics.

Podobenství o rozsévači je jedním z prvních velkých Ježíšových podobenství. Co se za ním skrývá, odkrývají v rozhovoru nad Markovým evangeliem Petr Vaďura a kazatel Jáchym Gondáš.Tento podcast můžete podpořit na https://radio7.cz

Mid Era: Selections of K. Markov (Croatia) under his moniker Markov Space with mixed sets of his previous releases that include different versions of some songs TIME ARTIST TRACK RELEASE 0:00:00 ***Intro***     0:00:00 Markov Space mixed 35 (excerpt) Mixed 35 0:30:37 Markov Space mixed 32 (excerpts) Mixed 32 0:51:46 Markov Space mixed 40 (excerpt) Mixed 40 1:08:14 Markov Space mixed 38 (excerpts) Mixed 38 1:29:29 Markov Space mixed 39 (excerpt) Mixed 39 1:47:49 Markov Space mixed 29 (excerpt) Mixed 29 1:58:44 ***Outro***       Keywords: International electronic music internet electronic artists unsigned electronic artists Low Orbit Satellite Ambient Symphonic Rock Progressive Rock Art Rock Tribal Trance PsyTrance Ethno/PsyTrance IDM Nonima Dub Step Mid Era Berlin School

In this landmark Mind-Body Solution Colloquia, cognitive scientist Donald Hoffman and neuroscientist Karl Friston engage in a deep, rigorous dialogue on the foundations of reality, perception, and consciousness.Hoffman argues that spacetime and physical objects are not fundamental, but evolved interfaces shaped by fitness rather than truth. Friston presents the Free Energy Principle and Active Inference as a unifying framework for life, mind, and meaning — raising the question of whether inference itself can ground reality.Together, they explore:- Why spacetime may be derived, not fundamental- Whether consciousness must come before physics- Markov blankets, trace logic, and system boundaries- Probability, inference, and non-equilibrium dynamics- The limits of scientific explanation- Implications for AI, evolution, and ontologyThis is not a debate — it is a serious attempt to understand reality at its deepest level.TIMESTAMPS:(00:00) - What is Ultimately Real? Consciousness vs Physicalism Debate(00:51) - Why Consciousness is Fundamental Beyond Spacetime(03:06) - High Energy Physics: Spacetime is Doomed Explained(05:06 - Challenges of Physicalist Theories in Explaining Consciousness(07:11 - Ontological Views: Free Energy Principle Integration(08:20) - Background-Free Explanations of Lived Experience(10:06) - Parsimony and Data Compression in Scientific Models(12:21) - Discoveries in Simpler Scattering Amplitude Solutions(14:09) - Free Energy Principle Guiding Beyond Spacetime Physics(16:06) - Why Physicalism Fails to Boot Up Consciousness(19:05) - Probability Theory's Role in Consciousness Frameworks(26:05) - Trace Logic Applied to Markov Chains Dynamics(34:51) - Markov Blankets and Insulation from the Past(39:07) - Minimizing Surprise in Non-Equilibrium Processes(53:32) - Spacetime as a Derived Projection from Fundamentals(1:04:15) - Constructing Simpler Explanations of Reality(1:20:50) - State Spaces and Dimensionality in Consciousness(1:41:30) - Non-Unique Bounds in AI Design Using Trace Logic(2:02:00) - From Classical Probability to Quantum Mechanics Transition(2:10:26) - Inferring Hidden Realities Through Relationships(2:18:54) - Time as a Computational Resource in Inference(2:24:09) - Scope and Limits of Scientific Explanations(2:32:32) - Agreements on Constructed Realities and Perceptions(2:40:01) - Closing Thoughts: Joint ManifestoEPISODE LINKS:- Karl's Round 1: https://youtu.be/Kb5X8xOWgpc- Karl's Round 2: https://youtu.be/mqzyKs2Qvug- Karl's Round 3 (Ft Mark Solms): https://youtu.be/Jtp426wQ-JI- Karl's Lecture 1: https://youtu.be/Gp9Sqvx4H7w- Karl's Lecture 2: https://youtu.be/Sfjw41TBnRM- Karl's Lecture 3: https://youtu.be/dM3YINvDZsY- Don's Round 1: https://youtu.be/M5Hz1giUUT8- Don's Round 2: https://youtu.be/Toq9YLl49KM- Don's Round 3: https://youtu.be/QRa8r5xOaAA- Don's Round 4: https://youtu.be/Hf1q-bZMEo4- Don's Lecture 1: https://youtu.be/r_UFm8GbSvU- Don's Lecture 2: https://youtu.be/YBmzqNIlbcICONNECT:- Website: https://mindbodysolution.org - YouTube: https://youtube.com/@MindBodySolution- Podcast: https://creators.spotify.com/pod/show/mindbodysolution- Twitter: https://twitter.com/drtevinnaidu- Facebook: https://facebook.com/drtevinnaidu - Instagram: https://instagram.com/drtevinnaidu- LinkedIn: https://linkedin.com/in/drtevinnaidu- Website: https://tevinnaidu.com=============================Disclaimer: The information provided on this channel is for educational purposes only. The content is shared in the spirit of open discourse and does not constitute, nor does it substitute, professional or medical advice. We do not accept any liability for any loss or damage incurred from you acting or not acting as a result of listening/watching any of our contents. You acknowledge that you use the information provided at your own risk. Listeners/viewers are advised to conduct their own research and consult with their own experts in the respective fields.

Send us a textWhat happens when artificial intelligence moves beyond images and begins interpreting clinical notes, kidney biopsies, multimodal cancer data, and even healthcare costs?In this episode, I open the year by exploring four recent studies that show how AI is expanding across the full spectrum of medical data. From Large Language Models (LLM) reading unstructured clinical text to computational pathology supporting rare kidney disease diagnosis, multimodal cancer prediction, and cost-effectiveness modeling in oncology, this session connects innovation with real-world clinical impact.Across all discussions, one theme is clear: progress depends not just on performance, but on integration, validation, interpretability, and trust.HIGHLIGHTS:00:00–05:30 | Welcome & 2026 Outlook New year reflections, global community check-in, and upcoming Digital Pathology Place initiatives.05:30–16:00 | LLMs for Clinical Phenotyping How GPT-4 and NLP automate phenotyping from free-text EHR notes in Crohn's disease, reducing manual chart review while matching expert performance.16:00–23:30 | AI Screening for Fabry Nephropathy A computational pathology pipeline identifies foamy podocytes on renal biopsies and introduces a quantitative Zebra score to support nephropathologists.23:30–29:30 | Is AI Cost-Effective in Oncology? A Markov model evaluates AI-based response prediction in locally advanced rectal cancer, highlighting when AI delivers value—and when it does not.29:30–38:30 | LLM-Guided Arbitration in Multimodal AI A multi-expert deep learning framework uses large language models to resolve disagreement between AI models, improving transparency and robustness.38:30–44:30 | Real-World AI & Cautionary Notes Ambient clinical scribing in practice, AI hallucinated citations, and why guardrails remain essential.KEY TAKEAWAYS• LLMs can extract meaningful clinical phenotypes from narrative notes at scale • AI can support rare disease diagnosis without replacing expert judgment • Economic value matters as much as technical performance • Explainability and arbitration are becoming critical in multimodal AI systems • Human oversight remains central to responsible adoptionResources & ReferencesDigital Pathology Place: https://www.digitalpathologyplace.comDigital Pathology 101 (free PDF, updates included)Automating clinical phenotyping using natural language processingZebra bodies recognition by artificial intelligence (ZEBRA): a computational tool for Fabry nephropathyCost-effectiveness analysis of artificial intelligence (AI) for response prediction of neoadjuvant radio(chemo)therapy in locally advanced rectal cancer (LARC) in the NetherlandsA multi-expert deep learning framework with LLM-guided arbitration for multimodal histopathology predictionSupport the showGet the "Digital Pathology 101" FREE E-book and join us!

“Naturalistic stimuli open up new exploration…”Dr. Christopher Baldassano is an associate professor at Columbia University and leads the Dynamic Perception and Memory Lab. With a background in electrical engineering from Princeton and a PhD in computer science from Stanford, Chris has pioneered innovative approaches to understanding memory and cognition. Following a postdoc at Princeton with Uri Hasson and Ken Norman, he joined Columbia in 2018. His research focuses on how the brain processes, stores, and retrieves events using naturalistic stimuli, hidden Markov models, and multivariate analysis techniques.In this episode, Peter and Chris explore the fascinating world of event structures and memory. They discuss Chris's pioneering work on event scripts, neural frameworks that act as cognitive scaffolds for autobiographical memories. The conversation covers how the brain segments continuous experience into discrete events, the role of event boundaries in memory encoding, and the critical function of the hippocampus in organizing these temporal structures. Chris explains his use of naturalistic stimuli and hidden Markov models to reveal the subtle dynamics of how we combine recurring information to respond more efficiently to future experiences. Along the way, Chris shares valuable insights on the evolution of neuroscience research and offers thoughtful advice for aspiring scientists navigating the field.We hope you enjoy this episode!Chapters:00:00 - Introduction07:37 - Transitioning from Computer Science to Neuroscience13:01 - Exploring Naturalistic Stimuli in Neuroscience18:11 - Hidden Markov Models in Narrative Perception22:46 - Event Boundaries and Memory Encoding27:49 - The Role of the Hippocampus in Memory33:01 - Implications for Mental Health and Memory Disorders38:19 - Enhancing Memory Techniques41:11 - Contextualization in Memory46:19 - Understanding Brain States49:01 - AI and Contextual Knowledge53:29 - Infant Cognition and Event Structures01:01:31 - Future Directions in ResearchWorks mentioned:2:28 - https://www.youtube.com/watch?v=jPLWOBmaLkY(Baldassano talk at NIH workshop on naturalistic stimuli)14:42 - https://pubmed.ncbi.nlm.nih.gov/28772125/(Baldassano et al., 2017 - Neuron - "Discovering Event Structure in Continuous Narrative Perception and Memory")15:02 - https://pubmed.ncbi.nlm.nih.gov/30249790/(Baldassano et al., 2018 - Journal of Neuroscience - "Representation of Real-world Event Schemas During Narrative Perception")18:24 - https://pubmed.ncbi.nlm.nih.gov/29087305/(Vidaurre, Smith & Woolrich, 2017 - PNAS - "Brain network dynamics are hierarchically organized in time" - using Markov models in a different way)19:41 - https://pubmed.ncbi.nlm.nih.gov/17338600/(Zacks et al., 2007 - Psychological Bulletin - "Event perception: A mind-brain perspective" - foundational work on event boundary processes)27:04 - https://pubmed.ncbi.nlm.nih.gov/27121839/(Huth et al., 2016 - Nature - "Natural speech reveals the semantic maps that tile human cerebral cortex" - semantic information stored throughout the brain)37:15 - https://pubmed.ncbi.nlm.nih.gov/22982082/(LePort et al., 2012 - Neurobiology of Learning and Memory - Jim McGaugh's study on highly superior autobiographical memory)53:01 - https://pubmed.ncbi.nlm.nih.gov/36252007/(Yates et al., 2022 - PNAS - "Neural event segmentation of continuous experience in human infants")Episode producers:Xuqian Michelle Li

Když se řekne „Království mýdlových bublin“, zní to jako název poetické pohádky. Jedná se však o celovečerní filmový dokument režisérky Taťány Markové, který otevírá bránu do světa rodiny Schichtových a jejich mýdlového impéria. Dokument i rodinu Schichtových v rozhovoru s Janem Pokorným přibližuje spolu s režisérkou také historik Martin Krsek, který na dokumentu spolupracoval. Film vstupuje 30. ledna do kin. V čem byla podnikatelská rodina Schichtových unikátní?Všechny díly podcastu Host Lucie Výborné můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

Když se řekne „Království mýdlových bublin“, zní to jako název poetické pohádky. Jedná se však o celovečerní filmový dokument režisérky Taťány Markové, který otevírá bránu do světa rodiny Schichtových a jejich mýdlového impéria. Dokument i rodinu Schichtových v rozhovoru s Janem Pokorným přibližuje spolu s režisérkou také historik Martin Krsek, který na dokumentu spolupracoval. Film vstupuje 30. ledna do kin. V čem byla podnikatelská rodina Schichtových unikátní?Všechny díly podcastu Host Radiožurnálu můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

In this episode of the Epigenetics Podcast, we talked with Will Wang from Sanford Burnham Prebys about his work on muscle stem cell repair, regeneration, and aging, exploring spatial-omics and machine learning. We begin our conversation by exploring the traditional concepts of spatial biology and how they have evolved to play a critical role in disease research. Dr. Wang recounts his journey from a young student in a family of academics to becoming a leading figure in regenerative biology, highlighting how his early interests in life sciences, natural problem-solving abilities, and inspirations from mentorship set the stage for his current research trajectory. Throughout the discussion, we uncover key insights on how muscle stem cells transition from a quiescent state to a proliferative state in response to injury and how this dynamic process is governed by the epigenetic landscape and various signalling pathways. Dr. Wang emphasises the impact of external factors—be it microenvironment conditions or metabolic cues—on the fate and function of these stem cells, reflecting on the methodologies used to investigate these processes throughout his career. He shares fascinating findings from his PhD work, where he explored the regulatory role of transcription factors like PAX-7 in muscle stem cell activation, and how subsequent research developed in his postdoc at Stanford further illuminated the relationship between metabolism and histone acetylation. This pivotal work not only demonstrated how metabolic states dictate epigenetic modifications but also offered potential therapeutic insights for muscle degeneration and repair. As we move into more recent projects, Dr. Wang discusses the advances in multiplexed spatial proteomics and the insights garnered from a single-cell spatiotemporal atlas of muscle regeneration, which highlight the cellular heterogeneity in muscle tissue. He describes the use of novel computational tools, including neural networks, to uncover the regulatory mechanisms underlying stem cell function, particularly how prostaglandin signalling informs the regeneration process and how age impacts stem cell efficacy. The episode then wraps up with an engaging dialogue about the future implications of Dr. Wang's work in addressing age-related muscle degradation and broader applications in regenerative medicine. References Yucel, N., Wang, Y. X., Mai, T., Porpiglia, E., Lund, P. J., Markov, G., Garcia, B. A., Bendall, S. C., Angelo, M., & Blau, H. M. (2019). Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function. Cell Reports, 27(13), 3939-3955.e6. https://doi.org/10.1016/j.celrep.2019.05.092 Wang, Y. X., Palla, A. R., Ho, A. T. V., Robinson, D. C. L., Ravichandran, M., Markov, G. J., Mai, T., Still, C., Balsubramani, A., Nair, S., Holbrook, C. A., Yang, A. V., Kraft, P. E., Su, S., Burns, D. M., Yucel, N. D., Qi, L. S., Kundaje, A., & Blau, H. M. (2025). Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. Cell Stem Cell, 32(7), 1154-1169.e9. https://doi.org/10.1016/j.stem.2025.05.012 Related Episodes Stem Cell Transcriptional Regulation in Naive vs. Primed Pluripotency (Christa Buecker) The Effect of Mechanotransduction on Chromatin Structure and Transcription in Stem Cells (Sara Wickström) Epigenetic Regulation of Stem Cell Self-Renewal and Differentiation (Peggy Goodell) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

In this episode of the Epigenetics Podcast, we talked with Will Wang from Sanford Burnham Prebys about his work on muscle stem cell repair, regeneration, and aging, exploring spatial-omics and machine learning. We begin our conversation by exploring the traditional concepts of spatial biology and how they have evolved to play a critical role in disease research. Dr. Wang recounts his journey from a young student in a family of academics to becoming a leading figure in regenerative biology, highlighting how his early interests in life sciences, natural problem-solving abilities, and inspirations from mentorship set the stage for his current research trajectory. Throughout the discussion, we uncover key insights on how muscle stem cells transition from a quiescent state to a proliferative state in response to injury and how this dynamic process is governed by the epigenetic landscape and various signalling pathways. Dr. Wang emphasises the impact of external factors—be it microenvironment conditions or metabolic cues—on the fate and function of these stem cells, reflecting on the methodologies used to investigate these processes throughout his career. He shares fascinating findings from his PhD work, where he explored the regulatory role of transcription factors like PAC-7 in muscle stem cell activation, and how subsequent research developed in his postdoc at Stanford further illuminated the relationship between metabolism and histone acetylation. This pivotal work not only demonstrated how metabolic states dictate epigenetic modifications but also offered potential therapeutic insights for muscle degeneration and repair. As we move into more recent projects, Dr. Wang discusses the advances in multiplexed spatial proteomics and the insights garnered from a single-cell spatiotemporal atlas of muscle regeneration, which highlight the cellular heterogeneity in muscle tissue. He describes the use of novel computational tools, including neural networks, to uncover the regulatory mechanisms underlying stem cell function, particularly how prostaglandin signalling informs the regeneration process and how age impacts stem cell efficacy. The episode then wraps up with an engaging dialogue about the future implications of Dr. Wang's work in addressing age-related muscle degradation and broader applications in regenerative medicine. References Yucel, N., Wang, Y. X., Mai, T., Porpiglia, E., Lund, P. J., Markov, G., Garcia, B. A., Bendall, S. C., Angelo, M., & Blau, H. M. (2019). Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function. Cell Reports, 27(13), 3939-3955.e6. https://doi.org/10.1016/j.celrep.2019.05.092 Wang, Y. X., Palla, A. R., Ho, A. T. V., Robinson, D. C. L., Ravichandran, M., Markov, G. J., Mai, T., Still, C., Balsubramani, A., Nair, S., Holbrook, C. A., Yang, A. V., Kraft, P. E., Su, S., Burns, D. M., Yucel, N. D., Qi, L. S., Kundaje, A., & Blau, H. M. (2025). Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. Cell Stem Cell, 32(7), 1154-1169.e9. https://doi.org/10.1016/j.stem.2025.05.012 Related Episodes Stem Cell Transcriptional Regulation in Naive vs. Primed Pluripotency (Christa Buecker) The Effect of Mechanotransduction on Chromatin Structure and Transcription in Stem Cells (Sara Wickström) Epigenetic Regulation of Stem Cell Self-Renewal and Differentiation (Peggy Goodell) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Na konci listopadu jsme si připomněli nedožité 80. narozeniny výjimečné herečky, rodačky ze Šternberka a velké milovnice Olomouce, paní Hany Maciuchové. Jak na tuto vzácnou osobnost s nezaměnitelným hlasem i charismatem vzpomíná její sestra Silvie Marková?

Na konci listopadu jsme si připomněli nedožité 80. narozeniny výjimečné herečky, rodačky ze Šternberka a velké milovnice Olomouce, paní Hany Maciuchové. Jak na tuto vzácnou osobnost s nezaměnitelným hlasem i charismatem vzpomíná její sestra Silvie Marková?Všechny díly podcastu Větrník - Host ve studiu můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

Diving into the question everyone suddenly cares about: how close are quantum computers to breaking Bitcoin?Friend of the pod Matt Wraith joins us to cut through the hype, the fear, and the sci-fi headlines and explain what's actually happening in quantum research right now, and what it means for Bitcoin security, signatures, and the long-term future of cryptography.We explore:- The theory of quantum mechanics- How quantum computers actually work- Shor's algorithm & Grover's algorithm- Quantum threat to Bitcoin- Recent advances in quantum computing- Post-quantum cryptography and quantum risk mitigation strategies for Bitcoin- Stoner bro quantum physics

The HabsWorld podcast crew was back to full strength and ready to talk about les Canadiens. Host Norm Szcyrek, with cohosts Paul Macleod, Sean Cayouette and Jonathan Rebelo, had a lot to say about the Habs, discussed other hockey news, and had some laughs. This podcast was recorded on December 4, 2025.Topics include:- Introductions, Habs trivia, Montreal trade tree- Mike Matheson contract extension; was this a Black Friday bargain for the Canadiens?- Engstrom call up and evaluating his play during his two games played- Jared Davidson fitting a fourth line role well- Struggles of Alexandre Carrier- David Reinbacher playing well in the AHL recently- Andrei Markov tribute December 3rd and Markov's impact on his teammates- Both Montreal goalies struggling for the last 4-5 weeks; what can be done?- Coach Martin St. Louis needs more development- Some trade rumours were discussed- Slakovsky may be playing his best hockey the past two weeks- Bolduc demotion to the fourth line; is this part of his development curve as a young player?- Texier's play with Montreal was discussed- Is Demidov's increased ice time key to his improved play?- Lane Hutson's 75 assists in his first 100 NHL games is the second best pace in NHL history!- Will Montreal be interested in trading for Kiefer Sherwood or Blake Coleman?- Could Nick Suzuki get bumped off Team Canada by players like Connor Bedard or Macklin Celebrini?- Updates on Habs prospects Alexander Zharovsky, Michael Hage, Bryce Pickford, L.J. Mooney, Hayden Paupanekis- Habs scouting staff mostly intact since Gorton/Hughes regime, but Canadiens appear to be much better at drafting- Florian Xhekaj's first call up to Montreal was analyzed- Around the NHL topics included Kyle Palmieri incredible play while injured, league parity at this point in the season, Jeff Chychrun excellent play and his eccentric home habits

Écoutez le meilleur des Amateurs de sports du jeudi 4 décembre 2025. Luc Tardif : «C’est frustrant, on sonne l’alerte depuis deux ans» Martin Brodeur : Le calendrier condensé affecte énormément les gardiens! Dany Dubé : «Markov cochait toutes les cases!» Jean-Sébastien Giguère : Nathan MacKinnon est tout simplement innarêtable Voir https://www.cogecomedia.com/vie-privee pour notre politique de vie privée

It's a heated debate every day… but no one drops the gloves. Get your daily diagnosis on the health of the Habs. The Habs Lunch with Sean Campbell and Mitch Gallo.

Dans son apéro, JiC nous parle du matchs Jets - Canadiens Jonathan Bernier nous résume la journée du CH. Maxim Lapierre décortique divers dossiers de la LNH. On félicite Russ Anber pour son intronisation au temple de la renommée de la boxe. Arnaud Gascon-Nadon nous donne les dernières nouvelles dans le monde du football. Tony Marinaro nous donne son opinion sur l'actualité sportive. Le syndicat des gardiens analyse divers cerbères de la LNH. Félix Séguin y va de son analyse hebdomadaire. Dans son billet de saison, JiC nous parle d'Andrei Markov. Alexandre Daigle passe en revue quelques sujets de la LNH. Renaud Lavoie nous parle de Zachary Bolduc, de jeu de puissance et d'Arber Xhekaj. Une production TVA Sports et QUB Décembre 2025Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr

À l’occasion de sa revue de presse, jeudi, Paul Arcand revient sur la sortie de Paul St-Pierre Plamondon concernant les artistes qui manquent, selon lui, de loyauté à l’égard du Québec. Lors d’un point de presse, le chef du Parti québécois a fustigé les porte-paroles du milieu culturel qui ont salué la nomination de Marc Miller comme ministre fédéral de la Culture. Il leur a reproché de manquer de décence alors que le nouveau ministre a suscité l’ire de plusieurs Québécois en disant être «tanné» du débat entourant le déclin du français. Dans une publication sur les réseaux sociaux, Paul St-Pierre Plamondon a même dénoncé l’aplaventrisme des porte-paroles qui représentent les artistes du Québec, soulignant qu’ils doivent agir de manière cohérente vis-à-vis les gestes du fédéral qui viennent affaiblir le rayonnement de la culture québécoise. Autres sujets abordés Un jeune tue ses parents et sa grand-mère, mais les psychiatres affirment qu’il n’est pas responsable de ses gestes; Cododo: un bébé de 26 jours meurt accidentellement; La saga entre Québec et les médecins; Le gouvernement Legault coupe l’aide sociale aux réfugiés, Les partisans des Canadiens rendent hommage à Andreï Markov. Voir https://www.cogecomedia.com/vie-privee pour notre politique de vie privée

Send us a textOn September 7, 1978, Georgi Markov, a Bulgarian defector living in London, was on his way to work. He left his car and crossed the Waterloo Bridge, which was part of his everyday routine. While waiting for the bus, Markov felt a stinging sensation in his right thigh. When he turned around, he saw a man picking up an umbrella from off the ground and running away. Not feeling well, Markov checked himself into the hospital on September 8. He was convinced there was something wrong with him. Markov was running a fever and complained of nausea and vomiting. He kept pointing to an area on his right side, stating that it was swollen and causing great pain. 4 days after the run in with the man with the umbrella, Georgi Markov was dead, at the age of 49 years old. Sources: 1) https://www.youtube.com/watch?v=HsVRYhLLPCM2) https://en.wikipedia.org/wiki/Georgi_Markov3) https://www.usagm.gov/news-and-information/threats-to-press/georgi-markov/4) https://spyscape.com/article/spy-murder-the-poisoned-umbrella-mystery-georgi-markov5) https://en.wikipedia.org/wiki/Francesco_Gullino6) https://www.theguardian.com/world/2023/mar/17/poison-umbrella-documentary-sheds-new-light-infamous-spy-killing-cold-war7) https://www.adamsmith.org/blog/georgi-markov-murdered-by-a-bulgarian-secret-service-assassin#:~:text=No%2Done%20was%20ever%20charged,destroyed%20to%20remove%20hard%20evidence.8) https://www.bloomberg.com/news/articles/2013-09-11/bulgaria-to-end-umbrella-murder-probe-after-35-years?embedded-checkout=trueSupport the show

There is one show where insiders share their secrets in this city. One person that they trust and respect. Opinion, reaction and the highest level of informed sports talk in Montreal. Melnick in the Afternoon, with Mitch Melnick.

How does a star form? How does the universe form? And how can we use every bit of astronomical data to answer those questions? To find out, Dr. Charles Liu and co-host Allen Liu welcome astrostatistician Sabrina Berger, all the way from Melbourne, Australia, where she's currently pursuing her PhD. As always, though, we start off with the day's joyfully cool cosmic thing, the new radioastronomy photographs of Callisto, one of the moons of Jupiter, taken by ALMA. Sabrina talks about her own low-frequency radio astronomy research looking for hydrogen in the very early reionization period of the universe when the first galaxies were forming. (Be warned: we dive into the difficulties ionization poses for trying to discern these early processes, including a side trip into quantum mechanics, the hyperfine transition of neutral hydrogen at 21cm depicted on the plaque attached to the Pioneer spacecraft, and even the Cosmic Background Radiation.) You'll also hear how Sabrina is innovatively using GPS satellites to help calibrate large radioastronomy telescope arrays. For our first student question, Derek asks, “I heard that black holes can form right after the Big Bang, before stars do. How is that possible?” Sabrina describes these primordial black holes, and, although none have been confirmed yet, that there have been a number of papers published recently on the subject. In fact, one paper suggesting that the as-yet-undiscovered “Planet 9” could even be one of these primordial black holes. And then, finally, we get to the subject of astrostatistics, Sabrina's area of expertise. She explains that it allows you to harness every piece of information that you're observing in astronomy and to answer questions like “How does a star form?” or “How does the universe form?” You'll hear about huge data sets, the use of artificial intelligence, field level inferences… and the MCMC, or the Markov chain Monte Carlo used in statistics. (If you don't know what that is, you're not alone, and our own resident mathematician Allen helps Sabrina untangle the complexity with a cotton ball analogy that blew Chuck and Sabrina's collective minds!) For our next student question, Wally asks, “Why is redshift one like nine billion years ago, bur redshift two only two billion years before that, and redshift three only one billion years before that?” As Chuck says, “that's a little complicated,” just before he, Allen and Sabrina proceed to explain how we measure universal expansion, the passage of time, and the “stretching” of light. Our next conversation is one of the most controversial we've ever had and revolves around who Sabrina thinks makes the best espresso, Australia, Italy or a “Third Wave Coffee Shop” like we have here in the US. You'll hear about why there's an ISSpresso machine on the ISS – and how the Italian Space Agency invented a way to make an espresso in zero-g! Plus, you'll hear a little about the work-life balance in Australia and how wonderful astronomy down under is. (Check out our Patreon for the story behind the Australian Aboriginal "Emu-in-the-sky" constellation.) If you'd like to know more about Sabrina, you can find her on Twitter and Blue Sky @sabrinastronomy or check out her research on her website. We hope you enjoy this episode of The LIUniverse, and, if you do, please support us on Patreon. Credits for Images Used in this Episode: An image of Jupiter's icy moon Callisto, photographed by NASA's Galileo spacecraft in 2001. – Credit: NASA/Galileo Photograph of Jupiter taken in 2019. The four fainter objects are four of its moons (left to right): Callisto, Ganymede, Io, and Europa. – Credit: Creative Commons / Rehman Abubakr ALMA images of Callisto – Credit: Maria Camarca et al 2025 Planet. Sci. J. 6 183. See the ALMA/Callisto paper: “A Multifrequency Global View of Callisto's Thermal Properties from ALMA”: https://iopscience.iop.org/article/10.3847/PSJ/ade7ee Timeline of the universe. – Credit: NASA, ESA, CSA, STScI The Pioneer plaques, attached to the Pioneer 10 and 11 spacecraft. – Credit: NASA Sedna orbit with solar system (Sun, Jupiter, Saturn, Uranus, Neptune and Pluto visible) and positions on Jan 1, 2017 – Credit: Creative Commons / Tom Ruen Redshift and universe expansion. As light travels from great distances to Hubble's mirrors, it is stretched to longer and longer red wavelengths, or cosmologically redshifted, as the universe expands. – Credit: NASA, ESA, Leah Hustak (STScI) The ISSpresso machine on the International Space Station.– Credit: NASA Astronaut Samantha Cristoforetti drinking espresso out of the cup on ISS, 2015 – Credit: NASA #liuniverse #charlesliu #allenliu #sciencepodcast #astronomypodcast #sabrinaberger #astrostatistician #astrostatistics #redshift #blackholes #primordialblackholes #callisto #alma #planet9 #sedna #universeexpansion #isspresso

¿Tus datos de conversión no cuadran? ¿Meta te dice una cosa, Google Analytics otra y tu CRM otra distinta? En este episodio, Pablo Moratinos, responsable de data, analítica y experimentación en Product Hackers, aterriza un tema tan complejo como crucial: la atribución.

Dr. Maxwell Ramstead grills Guillaume Verdon (AKA “Beff Jezos”) who's the founder of Thermodynamic computing startup Extropic.Guillaume shares his unique path – from dreaming about space travel as a kid to becoming a physicist, then working on quantum computing at Google, to developing a radically new form of computing hardware for machine learning. He explains how he hit roadblocks with traditional physics and computing, leading him to start his company – building "thermodynamic computers." These are based on a new design for super-efficient chips that use the natural chaos of electrons (think noise and heat) to power AI tasks, which promises to speed up AND lower the costs of modern probabilistic techniques like sampling. He is driven by the pursuit of building computers that work more like your brain, which (by the way) runs on a banana and a glass of water! Guillaume talks about his alter ego, Beff Jezos, and the "Effective Accelerationism" (e/acc) movement that he initiated. Its objective is to speed up tech progress in order to “grow civilization” (as measured by energy use and innovation), rather than “slowing down out of fear”. Guillaume argues we need to embrace variance, exploration, and optimism to avoid getting stuck or outpaced by competitors like China. He and Maxwell discuss big ideas like merging humans with AI, decentralizing intelligence, and why boundless growth (with smart constraints) is “key to humanity's future”.REFS:1. John Archibald Wheeler - "It From Bit" Concept00:04:45 - Foundational work proposing that physical reality emerges from information at the quantum levelLearn more: https://cqi.inf.usi.ch/qic/wheeler.pdf 2. AdS/CFT Correspondence (Holographic Principle)00:05:15 - Theoretical physics duality connecting quantum gravity in Anti-de Sitter space with conformal field theoryhttps://en.wikipedia.org/wiki/Holographic_principle 3. Renormalization Group Theory00:06:15 - Mathematical framework for analyzing physical systems across different length scales https://www.damtp.cam.ac.uk/user/dbs26/AQFT/Wilsonchap.pdf 4. Maxwell's Demon and Information Theory00:21:15 - Thought experiment linking information processing to thermodynamics and entropyhttps://plato.stanford.edu/entries/information-entropy/ 5. Landauer's Principle00:29:45 - Fundamental limit establishing minimum energy required for information erasure https://en.wikipedia.org/wiki/Landauer%27s_principle 6. Free Energy Principle and Active Inference01:03:00 - Mathematical framework for understanding self-organizing systems and perception-action loopshttps://www.nature.com/articles/nrn2787 7. Max Tegmark - Information Bottleneck Principle01:07:00 - Connections between information theory and renormalization in machine learninghttps://arxiv.org/abs/1907.07331 8. Fisher's Fundamental Theorem of Natural Selection01:11:45 - Mathematical relationship between genetic variance and evolutionary fitnesshttps://en.wikipedia.org/wiki/Fisher%27s_fundamental_theorem_of_natural_selection 9. Tensor Networks in Quantum Systems00:06:45 - Computational framework for simulating many-body quantum systems https://arxiv.org/abs/1912.10049 10. Quantum Neural Networks00:09:30 - Hybrid quantum-classical models for machine learning applicationshttps://en.wikipedia.org/wiki/Quantum_neural_network 11. Energy-Based Models (EBMs)00:40:00 - Probabilistic framework for unsupervised learning based on energy functionshttps://www.researchgate.net/publication/200744586_A_tutorial_on_energy-based_learning 12. Markov Chain Monte Carlo (MCMC)00:20:00 - Sampling algorithm fundamental to modern AI and statistical physics https://en.wikipedia.org/wiki/Markov_chain_Monte_Carlo 13. Metropolis-Hastings Algorithm00:23:00 - Core sampling method for probability distributionshttps://arxiv.org/abs/1504.01896 ***SPONSOR MESSAGE***Google Gemini 2.5 Flash is a state-of-the-art language model in the Gemini app. Sign up at https://gemini.google.com

Udruživanje unutar određenih industrija je uvek imalo za cilj unapređenje i razvoj cele industrije, poboljšanje tržišnog ambijenta za dalji rast i razvoj. O Srpskoj IT industriji se sada već priča više o deceniju, a od čuvene priče o novoj ‘'srpskoj malini'' i velikih očekivanja od ove industrije danas na žalost pričamo o velikoj krizi u IT industriji. Srpska IT Asocijacija je osnovana upravo sa ciljem da unapređenjem tržišnog ambijenta kroz menjanje zakonskih regulativa i poreskih olakšica našu IT industriju nastavi da gura napred, uprkos svim izazovima. O samoj asocijaciji, ciljevima, aktivnostima, ali i velikim izazovima koji ovih dana potresaju čitavu industriju u vidu ukidanja uredbe o podsticajima za novonastanjena lica, razgovarali smo sa Markom Vučetićem, Izvršnim direktorom asocijacije, u želji kako da predstavimo samo odruženje i njihove aktivnosti, tako i da otvoreno razgovaramo o trenutnim izazovima koji koče dalji razvoj industrije. Marko Vučetić, Izvršni direktor @ Srpska IT Asocijacija - https://www.linkedin.com/in/marko-vu%C4%8Deti%C4%87-495547155/ Srpska IT Asocijacija - https://sita.org.rs/ O čemu smo pričali sa Markom: - Uvod i predstavljanje - Markov background - SITA: Srpska IT Asocijacija - Fokus na poreske olakšice i regulativu - Vruća tema: Ukidanje podsticaja za novonastanjena lica - Dalji planovi i pravci razvoja Srpske IT asocijacije Pratite Digitalk podkast za više tema iz digitalnog marketinga, advertajzinga i karijere u kreativnoj industriji: LN: https://www.linkedin.com/company/digitalkrs FB: https://www.facebook.com/Digitalk.rs IG: https://www.instagram.com/digitalk.rs/ Posetite naš sajt i prijavite se na našu mailing listu - https://www.digitalk.rs Prijavite se na naš YouTube kanal: https://bit.ly/3uWtLES Veliku zahvalnost dugujemo kompanijama koje su prepoznale kvalitet onoga što radimo i odlučile da nas podrže i daju nam vetar u leđa: Partneri podkasta: - Raiffeisen banka - https://www.raiffeisenbank.rs/ Digitalne usluge Raiffeisen banke koje preporučujemo za mala i srednja preduzeća: https://bit.ly/451ZitQ - Kompanija NIS - https://www.nis.rs/ - Ananas - https://ananas.rs/ - kompanija Idea - https://online.idea.rs/ Prijatelj podkasta: - BiVits ACTIVA vitamini i minerali - https://bivits.com/kategorija/bivits-paketi/ Puno obaveza, stres, prekovremeni rad... zvuči poznato? E, za to imamo pravo rešenje. To su BiVits ACTIVA vitamini i minerali. Sa njima ćete lako uzeti zdravlje u svoje ruke i više od toga. Preporučujemo vam NO STRESS paket – kombinacija tri suplementa koja pomažu da se bolje naspavate, smanjite napetost i podignete energiju. Na BiVits sajtu možete pronaći kombinaciju koja je baš za vas, a uz poseban kod DIGITALK ostvarujete i 25% popusta! Uzmite zdravlje u svoje ruke – uz BiVits ACTIVA vitamine i minerale! - Izdavačka kuća Finesa - https://www.finesa.edu.rs/ U ovoj epizodi podelićemo dve knjige "'Ponašaj se kao lider, razmišljaj kao lider'" izdavačke kuće Finesa onima koji budu najbrži i najkreativniji sa komentarima, a možete nam slobodno pisati i na info@digitalk.rs i direktno nam uputiti komentar, sugestiju ili primedbu. Takođe, svi oni koji na Finesinom websajtu poruče knjige i unesu promo kod digitalk dobiće 10% popusta na već snižene cene izdanja na sajtu: https://www.finesa.edu.rs/

Unveil the secrets and past of Frantisek Markov, an insane surgeon obsessed with the mysteries of flesh and vivisection to create a perfect life form.

Et si face aux promesses de "progrès" on faisait plutôt preuve de discernement technologique ? On parle souvent d'inaction… mais que faire face aux verrous systémiques de la tech qui freinent l'action en faveur du climat ? Vous ne savez pas ce que c'est ? Pourtant, vous les subissez certainement en ce moment même. Surtout si vous travaillez en entreprise, et encore plus si vous êtes ce qu'on appelle des "décideurs" !Écoutez l'épisode complet Pourquoi le progrès technique nous mène droit dans le mur ou tapez directement "Trench Tech Bruno Markov" dans votre plateforme de podcastBruno Markov, ingénieur et essayiste, explore les impasses de l'accélération technologique. Son dernier ouvrage, De quel progrès avons-nous besoin ?, interroge notre culte de l'innovation technologique à l'heure des limites planétaires.(c) Trench Tech, LE podcast des « Esprits Critiques pour une Tech Éthique »Épisode enregistré le 23/05/2025---

Et si à force de bosser dans la tech et l'iA, on finissait par perdre la foi ? Bruno Markov, ex- consultant de haut niveau dans la tech, révèle ce qui l'a fait décrocher. Un témoignage saisissant sur la perte de sens dans l'innovation.Écoutez l'épisode complet Pourquoi le progrès technique nous mène droit dans le mur ou tapez directement "Trench Tech Bruno Markov" dans votre plateforme de podcastBruno Markov, ingénieur et essayiste, explore les impasses de l'accélération technologique. Son dernier ouvrage, De quel progrès avons-nous besoin ?, interroge notre culte de l'innovation technologique à l'heure des limites planétaires.(c) Trench Tech, LE podcast des « Esprits Critiques pour une Tech Éthique »Épisode enregistré le 23/05/2025---

Outline00:00 - Intro00:42 - “Research should be fun”02:02 - Early steps in research09:00 - Book writing and meeting C. Desoer18:33 - Control synthesis via the factorization approach25:46 - The graph metric 29:27 - Robotics and CAIR36:00 - Randomized algorithms40:41 - On learning44:05 - Neural networks48:40 - Tata, hidden Markov models, and large deviations theory55:48 - Picking problems and role of luck58:07 - Compressed sensing and non-convex optimization01:02:17 - Interplay between control and machine learning01:09:10 - Advice to future students01:13:29 - Future of controlLinksSagar's website: https://tinyurl.com/4hwruajsHilbert: https://tinyurl.com/ykpdh929Feedback Systems: https://tinyurl.com/2k3jsdatHow to Write Mathematics: https://tinyurl.com/35794bv9Nonlinear systems: https://tinyurl.com/2fdtnjcmC. Desoer: https://tinyurl.com/svhknrenControl Systems Synthesis — A Factorization Approach: https://tinyurl.com/59wdc4svAryabhata: https://tinyurl.com/43x6hfhpA Brief History of the Graph Topology: https://tinyurl.com/49uftzdkRobot Dynamics and Control: https://tinyurl.com/5b4cmt7mCAIR: https://tinyurl.com/rajdtxaxRandomized algorithms for robust controller synthesis using statistical learning theory: https://tinyurl.com/wanpyeucR. Tempo: https://tinyurl.com/jkufdwarVC dimension: https://tinyurl.com/mvwk8afmLearning and Generalisation: https://tinyurl.com/2s3mzh8hAre Analog Neural Networks Better Than Binary Neural Networks? https://tinyurl.com/3fnk27xcHidden Markov Processes: https://tinyurl.com/t5frrvfzAn Introduction to Compressed Sensing: https://tinyurl.com/fc6a8eerSupport the showPodcast infoPodcast website: https://www.incontrolpodcast.com/Apple Podcasts: https://tinyurl.com/5n84j85jSpotify: https://tinyurl.com/4rwztj3cRSS: https://tinyurl.com/yc2fcv4yYoutube: https://tinyurl.com/bdbvhsj6Facebook: https://tinyurl.com/3z24yr43Twitter: https://twitter.com/IncontrolPInstagram: https://tinyurl.com/35cu4kr4Acknowledgments and sponsorsThis episode was supported by the National Centre of Competence in Research on «Dependable, ubiquitous automation» and the IFAC Activity fund. The podcast benefits from the help of an incredibly talented and passionate team. Special thanks to L. Seward, E. Cahard, F. Banis, F. Dörfler, J. Lygeros, ETH studio and mirrorlake . Music was composed by A New Element.

Et si notre idée du progrès faisait fausse route ? Et si la tech nous faisait tout simplement dérailler ?Nos connaissances augmentent, donc on fabrique de meilleurs outils, donc ça profite au progrès technique, qui lui même profite au progrès scientifique... le tout dans le meilleur des mondes.MAIS EST-CE VRAIMENT LE CAS ??? Il y a beaucoup de choses aujourd'hui qui font que cette idylle n'est plus possible !Depuis les années 70, les signaux d'alerte s'accumulent… mais on accélère. Vers le mur.Écoutez l'épisode complet Pourquoi le progrès technique nous mène droit dans le mur ou tapez directement "Trench Tech Bruno Markov" dans votre plateforme de podcastBruno Markov, ingénieur et essayiste, explore les impasses de l'accélération technologique. Son dernier ouvrage, De quel progrès avons-nous besoin ?, interroge notre culte de l'innovation technologique à l'heure des limites planétaires.(c) Trench Tech, LE podcast des « Esprits Critiques pour une Tech Éthique »Épisode enregistré le 23/05/2025---

Le progrès technologique cache un piège invisible et toxique : les injonctions contradictoires qui nous tenaillent entre nécessité d'innover et de régler le problème du réchauffement climatique. Bruno Markov, ingénieur et essayiste, explore les impasses de l'accélération technologique. Son dernier ouvrage, De quel progrès avons-nous besoin ?, interroge notre culte de l'innovation technologique à l'heure des limites planétaires.Et si, loin d'être une solution, la promesse du "progrès" était devenu notre problème ? Dans cet épisode choc, Bruno Markov démonte les illusions d'un progrès déconnecté des réalités écologiques et sociales. Face à une IA qui promet tout et son contraire, aux promesses infinies d'une Silicon Valley hors-sol, il questionne les récits qui justifient l'emballement de nos sociétés.Pourquoi les décideurs, même conscients du mur, continuent-ils d'accélérer ? Quels sont les verrous invisibles qui paralysent l'action ? Bruno Markov éclaire les pièges du dilemme du prisonnier, les effets rebonds des technologies et le rôle des imaginaires dans nos visions du futur. Un épisode qui invite à réinventer le progrès, à sortir des dogmes technos et à remettre l'éthique et le discernement au cœur de nos choix.

  Today, Razib talks about a new paper, A structured coalescent model reveals deep ancestral structure shared by all modern humans: Understanding the history of admixture events and population size changes leading to modern humans is central to human evolutionary genetics. Here we introduce a coalescence-based hidden Markov model, cobraa, that explicitly represents an ancestral population split and rejoin, and demonstrate its application on simulated and real data across multiple species. Using cobraa, we present evidence for an extended period of structure in the history of all modern humans, in which two ancestral populations that diverged ~1.5 million years ago came together in an admixture event ~300 thousand years ago, in a ratio of ~80:20%. Immediately after their divergence, we detect a strong bottleneck in the major ancestral population. We inferred regions of the present-day genome derived from each ancestral population, finding that material from the minority correlates strongly with distance to coding sequence, suggesting it was deleterious against the majority background. Moreover, we found a strong correlation between regions of majority ancestry and human–Neanderthal or human–Denisovan divergence, suggesting the majority population was also ancestral to those archaic humans.

In this fascinating episode of Spybrary, host Shane Whaley takes us to the espionage heart of London with expert London Spy Tours guide David Harry, also known as The London Spy. From real-life Cold War betrayals to Bond-worthy locations and hidden relics, David shares captivating insights from his acclaimed Westminster and St. James's London spy tours. This episode is a treasure trove for spy fiction lovers and espionage history buffs alike.

Artificial intelligence has come a long way over just the past few years. It can hold conversations and manage social media, it can create art and edit videos, and it can even write blogs (though not this one). Every aspect of our lives has been touched by AI in one way or another, and that's particularly true for sound. While many podcasters, including some of my guests, now use AI tools for research and sound editing, it's also front and center in sound, from cloning voices to writing its own songs. Royalty-free music is already starting to give way to copyright-free AI music, and a variety of powerful audio content generation tools are scheduled for release later this year.But can computers replace human composers? Will listeners be able to tell the difference? And how did we get from vinyl records to virtual music? It may seem hard to believe, but the very first song written by a computer is older than cassette tapes. The Illiac Suite, or “String Quartet No. 4,” as it's officially named, was created in 1955, using pioneering techniques still found in AI today.The ILLIAC I (ill-ee-ack one) was one of the world's first computers. It was built in 1952 at the University of Illinois, and it filled an entire room. The ILLIAC I weighed five tons and used over two thousand vacuum tubes, some of which had to be replaced each night. A pair of music professors, Lejaren Hiller and Leonard Isaacson, programmed the ILLIAC to compose a string quartet using what's called “stochastic music,” music that's written using probability calculations and mathematical sequences – in this case, Markov chains – instead of human inspiration.One of the researchers who helped build the ILLIAC I was Saburo Muroga, who also built the MUSASINO-1 later that year in Japan. And, as it happens, another breakthrough in computer-generated music would emerge from Japan exactly fifty years after the Illiac Suite's release.Synthetic voices were the next step in creating digital music, and in 1961 the IBM 7094 became the first computer to sing a song, “Daisy Bell.” Another computer voice that could sing was called Perfect Paul, and it was one of the voice settings on 1983‘s text-to-speech DECtalk device. This is the speech synthesizer Professor Stephen Hawking used in his later years, and it was based on the voice of MIT researcher Dennis Klatt. The next decade brought us Auto-Tune, which can digitally modulate singing voices in real-time and has become, for better or worse, a staple of pop music.These developments all came together in 2004 as “Vocaloids,” synthesized voices that can talk and sing with perfect pitch. The most famous of them by far is Crypton Future Media's Hatsune Miku, a second-generation Vocaloid who debuted in 2007. While there have been four more generations and many more voices since then, Miku is the one who captured the public's eyes and ears. Arguably the world's first virtual celebrity, she's opened for Lady Gaga, put in a holographic appearance at the 2024 Coachella festival, and just wrapped up her latest ‘Miku Expo' world tour last December.In some ways, Miku and the Vocaloids that followed marked a turning point in synthetic voices. Older synthesizers like Perfect Paul and Microsoft Sam couldn't be mistaken for an ordinary person, but Vocaloids come closer than anything before – so close, in fact, that some music critics have said they fall into a sort of audio uncanny valley. They sound almost, but not quite, human.Now it's the year 2025, and AI has taken the stage: it's talking, singing, composing, and even creating whole new kinds of sound. Both OpenAI's Jukebox and Google's AI MusicLM can convert text into music, and Nvidia's upcoming Fugatto software is described as a sonic “Swiss Army knife” for creating sounds that have never existed, like a screaming saxophone or a trumpet that meows. Another new song-generation service by Musical AI and Beatoven.ai that's set to...

In an exclusive conversation, AI visionary Pedro shares insights into his groundbreaking contributions, including the unification of AI paradigms and the promise of neuro-symbolic AI. He reflects on key moments in his career and discusses the next frontiers in machine learning. 00:27- About Pedro Domingos Pedro Domingos is a Professor Emeritus of computer science and engineering at the University of Washington. He is a researcher in machine learning known for the Markov logic Network enabling uncertain inference.

******Support the channel****** Patreon: https://www.patreon.com/thedissenter PayPal: paypal.me/thedissenter PayPal Subscription 1 Dollar: https://tinyurl.com/yb3acuuy PayPal Subscription 3 Dollars: https://tinyurl.com/ybn6bg9l PayPal Subscription 5 Dollars: https://tinyurl.com/ycmr9gpz PayPal Subscription 10 Dollars: https://tinyurl.com/y9r3fc9m PayPal Subscription 20 Dollars: https://tinyurl.com/y95uvkao   ******Follow me on****** Website: https://www.thedissenter.net/ Facebook: https://www.facebook.com/thedissenteryt/ Twitter: https://x.com/TheDissenterYT   This show is sponsored by Enlites, Learning & Development done differently. Check the website here: http://enlites.com/   Dr. Kathryn Nave is a Leverhulme Trust early career research fellow at the University of Edinburgh. Her research focuses on developing a realist account of autonomy and agency, grounded in the uniquely metabolic existence of living systems, and upon critiquing the machine concept of the organism in light of this distinctive material instability. She is the author of A Drive to Survive: The Free Energy Principle and the Meaning of Life.   In this episode, we focus on A Drive to Survive. We first discuss enactivism, and the notions of intentionality, autopoiesis, autonomy, adaptivity, and predictive processing. We then get into the Free Energy Principle, and talk about generative models, Markov blankets, living agents, purposiveness and goal-directedness, and biological survival. We discuss the limitations of the Free Energy Principle in differentiating between living and non-living systems, the instability of living systems, and how we can go beyond the Free Energy Principle framework. -- A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: PER HELGE LARSEN, JERRY MULLER, BERNARDO SEIXAS, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, FILIP FORS CONNOLLY, DAN DEMETRIOU, ROBERT WINDHAGER, RUI INACIO, ZOOP, MARCO NEVES, COLIN HOLBROOK, PHIL KAVANAGH, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, FERGAL CUSSEN, HAL HERZOG, NUNO MACHADO, JONATHAN LEIBRANT, JOÃO LINHARES, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, ROMAIN ROCH, DIEGO LONDOÑO CORREA, YANICK PUNTER, CHARLOTTE BLEASE, NICOLE BARBARO, ADAM HUNT, PAWEL OSTASZEWSKI, NELLEKE BAK, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, PAULO TOLENTINO, JOÃO BARBOSA, JULIAN PRICE, EDWARD HALL, HEDIN BRØNNER, DOUGLAS FRY, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, SCOTT, ZACHARY FISH, TIM DUFFY, SUNNY SMITH, JON WISMAN, WILLIAM BUCKNER, PAUL-GEORGE ARNAUD, LUKE GLOWACKI, GEORGIOS THEOPHANOUS, CHRIS WILLIAMSON, PETER WOLOSZYN, DAVID WILLIAMS, DIOGO COSTA, ANTON ERIKSSON, ALEX CHAU, AMAURI MARTÍNEZ, CORALIE CHEVALLIER, BANGALORE ATHEISTS, LARRY D. LEE JR., OLD HERRINGBONE, MICHAEL BAILEY, DAN SPERBER, ROBERT GRESSIS, IGOR N, JEFF MCMAHAN, JAKE ZUEHL, BARNABAS RADICS, MARK CAMPBELL, TOMAS DAUBNER, LUKE NISSEN, KIMBERLY JOHNSON, JESSICA NOWICKI, LINDA BRANDIN, NIKLAS CARLSSON, GEORGE CHORIATIS, VALENTIN STEINMANN, PER KRAULIS, KATE VON GOELER, ALEXANDER HUBBARD, BR, MASOUD ALIMOHAMMADI, JONAS HERTNER, URSULA GOODENOUGH, DAVID PINSOF, SEAN NELSON, MIKE LAVIGNE, JOS KNECHT, ERIK ENGMAN, LUCY, YHONATAN SHEMESH, MANVIR SINGH, PETRA WEIMANN, PEDRO BONILLA, CAROLA FEEST, STARRY, MAURO JÚNIOR, 航 豊川, TONY BARRETT, AND BENJAMIN GELBART! A SPECIAL THANKS TO MY PRODUCERS, YZAR WEHBE, JIM FRANK, ŁUKASZ STAFINIAK, TOM VANEGDOM, BERNARD HUGUENEY, CURTIS DIXON, BENEDIKT MUELLER, THOMAS TRUMBLE, KATHRINE AND PATRICK TOBIN, JONCARLO MONTENEGRO, AL NICK ORTIZ, NICK GOLDEN, AND CHRISTINE GLASS! AND TO MY EXECUTIVE PRODUCERS, MATTHEW LAVENDER, SERGIU CODREANU, BOGDAN KANIVETS, ROSEY, AND GREGORY HASTINGS!

Godinu počinjemo sa presekom stanja na medijskom tržištu Srbije i regiona. Od prošle godine, sagovornike za novogodišnju i prvu epizodu u septembru mesecu nominuju prethodni sagovornici, a za prvu epizodu u 2025. godini nominovan je Marko Šobot, medijski stručnjak sa višedecenijskim iskustvom u radu sa prevashodno offline medijima. Kroz bogatu karijeru gde je iskustvo kalio u velikim sistemima poput Direct Media-e i Publicis-a, a danas u ulozi CEO-a agencije Plus Media, Marko je sa nama podelio svoje uvide i iskustva kada je u pitanju srpsko medijsko tržište, kako veliki igrači gledaju na nas kao region, kako danas funkcionišu klijenti, zašto agencije imaju problema da zadrže kadrove, te zašto su i danas i te kako važni offline mediji, uz pravilno segmentiranje i istraživanje tržišta. Marko Šobot, CEO @ Plus Media - https://www.linkedin.com/in/marko-%C5%A1obot-87b36a33/ Teme u epizodi: - Uvod i predstavljanje - Markov profesionalni put od arhitekte do okorelog medijaša - Medijsko tržište: mi i region - Šta su donele dve nejveće krize u poslednjih 20 godina, a šta odnele - Televizija prvi put ispod 50% - koja je budućnost linearne televizije? - Klijenti danas - Agencije: zašto više nismo interesantni mladima - Mediji: nema medija koji ne rade, samo treba sklopiti kockice - AI – da li ostajemo bez posla i zašto ne - Poruka za kraj Prijavite se na naš YouTube kanal: https://bit.ly/3uWtLES Posetite naš sajt i prijavite se na našu mailing listu - https://www.digitalk.rs Pratite DigiTalk.rs na društvenim mrežama: Facebook: https://www.facebook.com/Digitalk.rs Instagram: https://www.instagram.com/digitalk.rs/ Linkedin: https://www.linkedin.com/company/digitalkrs Veliku zahvalnost dugujemo kompanijama koje su prepoznale kvalitet onoga što radimo i odlučile da nas podrže i daju nam vetar u leđa: Partneri podkasta: - Raiffeisen banka - https://www.raiffeisenbank.rs/ Digitalne usluge Raiffeisen banke koje preporučujemo za mala i srednja preduzeća: https://bit.ly/4j2pMjU - Kompanija NIS - https://www.nis.rs/ - Ananas - https://ananas.rs/ - kompanija Idea - https://online.idea.rs/ U Ideinoj online prodavnici unesite promo kod 1000digitalk i očekuje vas 1.000 dinara popusta prilikom vaše online kupovine! Prijatelj podkasta: - PerformLabs - https://performlabs.agency/ Oslobodite pun potencijal svog digitalnog marketinga! Optimizujte svoje kampanje i postignite maksimalne rezultate uz Performlabs. - BiVits ACTIVA Brain Level Up Booster - https://bivits.com/proizvod/brain-level-up/ Kada želiš da živiš i radiš na višem nivou, uzmi BiVits Brain Level Up za više energije i bolju koncentraciju tokom dana! - Izdavačka kuća Finesa - https://www.finesa.edu.rs/ U ovoj epizodi podelićemo dve knjige "Ponašaj se kao lider, razmišljaj kao lider" izdavačke kuće Finesa onima koji budu najbrži i najkreativniji sa komentarima, a možete nam slobodno pisati i na info@digitalk.rs i direktno nam uputiti komentar, sugestiju ili primedbu. Takođe, svi oni koji na Finesinom websajtu poruče knjige i unesu promo kod digitalk dobiće 10% popusta na već snižene cene izdanja na sajtu: https://www.finesa.edu.rs/

******Support the channel****** Patreon: https://www.patreon.com/thedissenter PayPal: paypal.me/thedissenter PayPal Subscription 3 Dollars: https://tinyurl.com/ybn6bg9l PayPal Subscription 5 Dollars: https://tinyurl.com/ycmr9gpz PayPal Subscription 10 Dollars: https://tinyurl.com/y9r3fc9m PayPal Subscription 20 Dollars: https://tinyurl.com/y95uvkao   ******Follow me on****** Website: https://www.thedissenter.net/ The Dissenter Goodreads list: https://shorturl.at/7BMoB Twitter: https://x.com/TheDissenterYT   This show is sponsored by Enlites, Learning & Development done differently. Check the website here: http://enlites.com/   Dr. Karl Friston is Professor of Imaging Neuroscience and Wellcome Principal Research Fellow of Imaging Neuroscience at University College London. Dr. Friston is a theoretical neuroscientist and authority on brain imaging. He invented statistical parametric mapping (SPM), voxel-based morphometry (VBM) and dynamic causal modelling (DCM). His main contribution to theoretical neurobiology is a free-energy principle for action and perception.   In this episode, we explore the Free Energy Principle, and how to go from physical systems to brains and cognition. We start by discussing what the Free Energy Principle is, the history behind its development, and concepts like Markov blankets, internal and external states, blanket states, circular causality, and autonomous states. We talk about the differences between living and non-living systems, and the existential imperative to reduce predicting error. We also discuss concepts like self-organization and hierarchy in nervous systems. We discuss what we can learn about the brain through neuroimaging, and how specialized the brain is. Finally, we talk about how we can integrate the microscopic aspects of brain physiology with a more abstract understanding of the mind, like what we have in psychiatry and psychology. -- A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: PER HELGE LARSEN, JERRY MULLER, BERNARDO SEIXAS, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, FILIP FORS CONNOLLY, DAN DEMETRIOU, ROBERT WINDHAGER, RUI INACIO, ZOOP, MARCO NEVES, COLIN HOLBROOK, PHIL KAVANAGH, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, FERGAL CUSSEN, HAL HERZOG, NUNO MACHADO, JONATHAN LEIBRANT, JOÃO LINHARES, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, ROMAIN ROCH, DIEGO LONDOÑO CORREA, YANICK PUNTER, CHARLOTTE BLEASE, NICOLE BARBARO, ADAM HUNT, PAWEL OSTASZEWSKI, NELLEKE BAK, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, PAULO TOLENTINO, JOÃO BARBOSA, JULIAN PRICE, EDWARD HALL, HEDIN BRØNNER, DOUGLAS FRY, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, SCOTT, ZACHARY FISH, TIM DUFFY, SUNNY SMITH, JON WISMAN, WILLIAM BUCKNER, PAUL-GEORGE ARNAUD, LUKE GLOWACKI, GEORGIOS THEOPHANOUS, CHRIS WILLIAMSON, PETER WOLOSZYN, DAVID WILLIAMS, DIOGO COSTA, ALEX CHAU, AMAURI MARTÍNEZ, CORALIE CHEVALLIER, BANGALORE ATHEISTS, LARRY D. LEE JR., OLD HERRINGBONE, MICHAEL BAILEY, DAN SPERBER, ROBERT GRESSIS, IGOR N, JEFF MCMAHAN, JAKE ZUEHL, BARNABAS RADICS, MARK CAMPBELL, TOMAS DAUBNER, LUKE NISSEN, KIMBERLY JOHNSON, JESSICA NOWICKI, LINDA BRANDIN, NIKLAS CARLSSON, GEORGE CHORIATIS, VALENTIN STEINMANN, PER KRAULIS, ALEXANDER HUBBARD, BR, MASOUD ALIMOHAMMADI, JONAS HERTNER, URSULA GOODENOUGH, DAVID PINSOF, SEAN NELSON, MIKE LAVIGNE, JOS KNECHT, ERIK ENGMAN, LUCY, MANVIR SINGH, PETRA WEIMANN, CAROLA FEEST, STARRY, MAURO JÚNIOR, 航 豊川, TONY BARRETT, BENJAMIN GELBART, NIKOLAI VISHNEVSKY, STEVEN GANGESTAD, AND TED FARRIS! A SPECIAL THANKS TO MY PRODUCERS, YZAR WEHBE, JIM FRANK, ŁUKASZ STAFINIAK, TOM VANEGDOM, BERNARD HUGUENEY, CURTIS DIXON, BENEDIKT MUELLER, THOMAS TRUMBLE, KATHRINE AND PATRICK TOBIN, JONCARLO MONTENEGRO, AL NICK ORTIZ, NICK GOLDEN, AND CHRISTINE GLASS! AND TO MY EXECUTIVE PRODUCERS, MATTHEW LAVENDER, SERGIU CODREANU, BOGDAN KANIVETS, ROSEY, AND GREGORY HASTINGS!

Send us a textIn this episode, Joey Pinz sits down with Alex Markov, a visionary leader in the tech industry, who shares his journey from founding a Managed Service Provider (MSP) to developing a successful SaaS platform, Strategy Overview. Alex's passion for design, both in physical spaces and technology, has driven him to create solutions that streamline workflows and improve client experiences. He discusses the importance of standardization in MSPs, the transition from MSP operations to SaaS development, and the innovative use of AI to optimize business processes. Alex also emphasizes the significance of redefining work to enhance both personal and professional life. This conversation is packed with insights for tech enthusiasts and business leaders alike.Top 3 Highlights:Alex Markov's transition from running an MSP to launching a successful SaaS platform.The role of design and standardization in creating efficient business operations.How AI is revolutionizing the MSP industry by optimizing client management processes.Hashtags:#TechInnovation #MSP #SaaS #AI #BusinessGrowth #DesignThinking #WorkplaceWellness #Leadership Join us for enlightening discussions that spark growth and exploration. Hosted by Joey Pinz, this Discipline Conversations Podcast offers insights and inspiration. 

durée : 00:50:03 - Le Masque et la Plume - par : Laurent Goumarre - Nos critiques ont lu "Le barman du Ritz" de Philippe Collin, "Pour les siècles des siècles" d'Alain Guiraudie, "Nous vivrons" de Joann Sfar, "Du côté sauvage" de Tiffany McDaniel et "Les chaînes de Markov" de Noham Selcer et vous conseillent, ou pas, de les lire cet été. - invités : Blandine Rinkel, Laurent CHALUMEAU, Hubert ARTUS, Raphaelle Leyris - Blandine Rinkel : Écrivaine et musicienne, Laurent Chalumeau : Journaliste rock, scénariste, dialoguiste, romancier, Hubert Artus : Journaliste et chroniqueur littéraire, Raphaëlle Leyris : Journaliste au Monde, critique littéraire - réalisé par : Audrey RIPOULL

Together with Richard Brennan, we discuss the optimal way of doing trend following and how to find the optimal set of rules to use in different market regimes, how to examine market states through Markov models and how artificial intelligence will impact trend following and make short-term trading incredibly competitive. Lastly, we ask ChatGPT what the optimal way of doing trend following is.-----EXCEPTIONAL RESOURCE: Find Out How to Build a Safer & Better Performing Portfolio using this FREE NEW Portfolio Builder Tool-----Follow Niels on Twitter, LinkedIn, YouTube or via the TTU website.IT's TRUE ? – most CIO's read 50+ books each year – get your FREE copy of the Ultimate Guide to the Best Investment Books ever written here.And you can get a free copy of my latest book “Ten Reasons to Add Trend Following to Your Portfolio” here.Learn more about the Trend Barometer here.Send your questions to info@toptradersunplugged.comAnd please share this episode with a like-minded friend and leave an honest Rating & Review on iTunes or Spotify so more people can discover the podcast.Follow Rich on Twitter.Episode TimeStamps:01:04 - What has been on our radar recently?04:03 - Industry performance update07:50 - Q1, Dennis: Given the nature of lengthy hold periods, do you recommend trading cash CFD's accounting for the overnight costs?11:40 - Q2, Ramki: Using ATR for position sizing when backtesting a trend following system14:47 - Optimal rules to use in different kinds of market regimes18:46 - How to use Markov models and mathematical algorithms to optimize trend following strategies41:17 - Is trend following threatened by AI?51:39 - "ChatGPT, what is the optimal way of doing trend following?"Copyright © 2024 – CMC AG – All Rights Reserved----PLUS: Whenever you're ready... here are 3 ways I can help you in your investment Journey:1. eBooks that cover key topics that you need to know about In my eBooks, I put together some key discoveries and things I have learnt during the more than 3 decades I have worked in the Trend Following industry, which I hope you will find useful.