Podcasts about bowel cancer

Ian Sample is joined by James Kinross, colorectal surgeon and author of the book Dark Matter: The New Science of the Microbiome, to answer all your questions about gut health. In episode one, James explains how the gut microbiome gets set up, how it impacts our early development, and the effect antibiotics can have on our microbes. Help support our independent journalism at theguardian.com/sciencepod

We hear a lot about the pressures boys and young men are under and how many of them are looking to the online world - or manosphere as it's sometimes called - to find answers. Prompted by the drama Adolescence on Netflix, the topic has been in the news regularly in recent weeks. This week the Women and Equalities Select Committee heard evidence on the manosphere. Anita Rani is joined by Will Adolphy, who was a dedicated follower of the manosphere until, in his mid 20s, he had a breakdown. He went offline for five years and rebuilt his life. He is now a psychotherapist, coach, and goes to schools to speak about healthy masculinity.This week ITV has announced a shake up of the scheduling and production of its popular daytime shows including Lorraine, Loose Women and Good Morning Britain. Whilst Good Morning Britain will be extended, both Lorraine and Loose Women will see their number of shows cut. Entertainment journalist and expert on all-things TV Scott Bryan unpicks why this is happening.The Bombing of Pan Am 103 – is a new BBC factual drama series. Based on the true story of the bombing of a passenger flight over a small Scottish town of Lockerbie on 21 December 1988, in which 270 people were killed. Kathryn Turman was Assistant to a federal Senator at the time of the bombing. After the trial she joined the FBI where she founded the agency's first ever Victim Services Division. Her experience in the aftermath of the Pan Am bombing proved invaluable to the FBI's response to the 9/11 attacks, and she has aided victims and families throughout major moments in history including the Las Vegas shooting and the Boston marathon bombing. She discusses her mission to help victims, and what inspired her work in public service.Next month marks three years since the journalist and host of BBC's You, Me and the Big C podcast Deborah James - known to many as Bowel Babe - died, aged 40, five years after her stage four bowel cancer diagnosis. Bowel cancer is the third most common cancer type and cause of cancer death for women. Since the early 1990s, the incidence rate in women aged 25-49 has increased by almost 60%. Bowel cancer is treatable if diagnosed early. Heather James, Deborah's mother, is fulfilling a promise to her daughter and continuing with Deborah's awareness-raising work - she and Michelle Mitchell, Chief Executive of Cancer Research UK, are in the Woman's Hour studio.Presenter: Anita Rani Producer: Kirsty Starkey

Orby is back even though there has been less pinball news then code in Dune Orby tries to salavage a show! WARNING my voice is fricked up for aboot half the shw sorry not sorry! xoxo Support my buddy Kimba and the fight against Bowel Cancer by donating to your local cancer charity or for Kimbas Bday I will drop a link to specifically donate in her name! >>>  https://www.facebook.com/donate/620383734386452/10236256121563864/ 

Bowel Cancer sufferers, survivors and their supporters gathered at Parliament on Tuesday to call on the Government to lower the age of eligibility for free bowel cancer screening tests. Several dozen protesters met with Ministers to raise awareness of the growing problem and to call for change in how the disease is diagnosed in Aotearoa. Bill Hickman has more. 

Last year the government announced it's progressively lowering eligibility for free bowel cancer screening to 58 years old, down from 60. It also ended a pilot programme that allowed Maori and Pasifika to access bowel screening at 50. That's despite Christopher Luxon's pre-election promise to match Australia's screening age of 45 years old. Rachael Ferguson spoke to Lisa Owen. 

Can Gut Health in Childhood Help Prevent Bowel Cancer Later in Life?This week on the podcast, we're talking about something that might feel a little confronting but also incredibly empowering: how our kids' health today could shape their future health tomorrow.Bowel cancer rates are on the rise in young people, and new research is pointing to a surprising contributor — one we've been talking about for a long time here at Natural Super Kids: gut health. In this episode, we will break down what this means for parents without fear, but with practical action in mind.Here's what we cover:What the latest research says about childhood gut bacteria and bowel cancer risk.How early-life factors like C-section births, antibiotics, and diet can impact long-term gut health.Subtle signs that your child's gut may be out of balance — from tummy troubles to mood changes.Easy, gut-supportive changes you can start making right now (even if life feels busy).

Kaz and Tubes check in with Huon Valley local, Matt Duggan, who has just completed 12 marathons in 12 days from Cockle Creek to Stanley, raising over $100,000 for bowel cancer.See omnystudio.com/listener for privacy information.

TODAY ON THE ROBERT SCOTT BELL SHOW: LIVE from Beljanski Integrative Cancer Conference, Stage "0" Cancer, RFK vs Food Dyes, CDC COVID Vaccine Recommendation?, Food Linked to Mood, Rising Youth Cancers, Toxin Exposure vs Bowel Cancer, RFK Vaccine Reporting Battle, Autism Vaccine Belief Surges, Teen Mood Crisis, and MORE! https://robertscottbell.com/live-from-beljanski-integrative-cancer-conference-stage-0-cancer-rfk-vs-food-dyes-cdc-covid-vaccine-recommendation-food-linked-to-mood-rising-youth-cancers-toxin-exposure-vs-bowel-cancer-r/

Kaz and Tubes chat with Matt Duggan ahead of his 12-day Marathon Mission for Cancer Council Tasmania, running from Cockle Creek to Stanley to raise awareness that bowel cancer isn’t just an ‘old-person's disease’.See omnystudio.com/listener for privacy information.

To mark bowel cancer awareness month we discuss the disease, the warning signs and the importance of screening in identifying it early.Sean speaks with Galway man Joe Grogan who faced his own cancer battle after a routine screen warned him something was wrong. And consultant Dr Alan Smith from the HSE national screening service discusses plans to expand screening and the concerning rise in bowel cancer in young people which doctors have yet to find the cause of.

Dr Theo Portlock from the Liggins Institute speaks to Jonny about his research into alternative approaches to Bowel Cancer detection in Aotearoa. Thanks to the University of Auckland. 

April is Bowel Cancer Awareness Month, and the Irish Cancer Society's ‘Your Health Matters' Roadshow is making a stop at Gorey Shopping Centre this week. On hand to tell us more about what to expect — from free health checks to cancer awareness advice — is Sarah Egan, Cancer Awareness Nurse with the Irish Cancer Society.

April is bowel cancer awareness month. With this in mind we talk to Dr Alan Desmond, consultant gastroenterologist, about how to reduce our risk of developing bowel cancer, one of the commonest cancers in the Western world, and how diet and lifestyle can improve prognosis for people already living with this condition. Alan is a practising clinician, author of 'The Plant-Based Diet Revolution', a well known speaker and now a successful podcaster with his new podcast - ‘Eat This with Dr Alan Desmond', as well as being an Ambassador for Plant-Based Health Professionals UK. For many years Alan has been advocating for a high fibre whole food plant-based diet, for gut health and to reduce the risk of many chronic conditions. To connect with Alan: https://www.alandesmond.com/ https://www.instagram.com/dr.alandesmond/ Details and tickets for the Nutrition and Lifestyle Medicine Conference: https://nlmc.org.uk/ Details for joining Plant-Based Health Professionals UK: https://plantbasedhealthprofessionals.com/membership Factsheets from Plant-Based Health Professionals : https://plantbasedhealthprofessionals.com/wp-content/uploads/2019/07/Bowel-Cancer-Prevention.pdf https://plantbasedhealthprofessionals.com/wp-content/uploads/2019/07/Colon-Cancer.pdf https://plantbasedhealthprofessionals.com/wp-content/uploads/2023/12/Colonoscopy-on-a-vegan-diet-231208.pdf Studies discussed: https://www.who.int/news-room/questions-and-answers/item/cancer-carcinogenicity-of-the-consumption-of-red-meat-and-processed-meat https://www.bmj.com/content/378/bmj-2021-068921 https://eatforum.org/eat-lancet-commission/the-planetary-health-diet-and-you/ https://www.ceu.ox.ac.uk/research/epic-oxford-1 https://adventisthealthstudy.org/studies/AHS-2/findings-lifestyle-diet-disease https://www.bluezones.com/ https://www.wcrf.org/preventing-cancer/cancer-prevention/our-cancer-prevention-recommendations/ https://ascopubs.org/doi/full/10.1200/JCO.21.01784 https://www.nature.com/articles/s41467-024-55219-5

Bowel Cancer – Why Screening Saves Lives • How the simple at-home screening test can detect cancer early and improve survival rates.See omnystudio.com/listener for privacy information.

We've received another one of these “the Government went against official advice“ stories. This one was around bowel testing. The Government has recently announced that testing has dropped in age from 60 to 58-years-old. The money to pay for that extra testing has come from the separate Māori and Pacific testing, which cuts in at 50-years-old. The official advice is that more lives could be saved if you tested more Māori and Pacific Islanders. The new health minister said in response that what we need to do to save more lives is test more people. He is of course unquestionably right, because the word "people" is critical. We are all people and, given we all contribute to the system that tests us, exempting some from access i.e a non-Māori , is not right. Yet again, this is part of the race-based system we have in this country, which hopefully is slowly but surely being dismantled. Adding to this official advice part of the story is my increasing concern based on the Brian Roache report into the public service and the Deloitte report into Health NZ. It's possible this so-called "official advice" is either pointless or politically motivated. If you start with a system that anyone at anytime can get a test, and then work backwards because that is not effective or affordable, at some point you come to a hap-ish, affordable medium. Age will be a factor because there's no point in bowel testing a 29-year-old. So what is the magic number? They have decided 60years-old, until they decided 58-years-old. Breast screening mammogram have gone through the same debate. But at no point should race be a factor. Yet, it has been. Having just completed my first state participant bowel screen I would be deeply offended if I was bumped, delayed or stopped simply because I am not Maori or Pasifika. I am a taxpayer and a New Zealander. My right is no more or less important or relevant than anyone else's and yet there are those that would argue otherwise. By prioritising race, you are saying one life is worth more than another. You can't do that That's what makes the official advice wrong.See omnystudio.com/listener for privacy information.

Physicians are coming down hard on the Government's evidence being used to prop up their changes to bowel cancer funding. Last week, the Government announced it will scrap a programme lowering the screening age for Māori and Pacific people, decreasing the age to 58 for everyone instead. Royal Australasian College of Physicians's Dr Matt Wheeler says the claim that bowel cancer risk is similar across all groups at the same age isn't true. "The actual peak age of diagnosis is earlier in Māori than non-Māori. That was why the original screening programme had bowel screenings down to the age of 50." LISTEN ABOVESee omnystudio.com/listener for privacy information.

Chris Hipkins was asked on Q&A if his party will be campaigning on capital gains tax at the next election, Hipkins says Labour hasn't decided yet. We wonder if not answering this is a net negative, a net positive or neutral at this stage in the cycle.Friend of the show Sam Seder went on Jubilee's Surrounded show where he faced off against 20 young conservatives. One answer in particular seemed to sum up the views of the modern conservative millennial and Gen Z crowd which showed how their idea of white supremacy is so out in the open and casual now it almost (to them) seems normal.Simeon Brown and the Coalition Government's plans to lower the age for free bowel cancer screening for all New Zealanders by "redirecting" money previously set aside to lower the age for Māori and Pasifika has been described as "disappointing". It will lead to more Maori and Pasifika peoples dying early and is another broken promise by this governmentMehdi Hasan shows us all, while talking to former Republican Congressman Joe Walsh, how to stay away from the whataboutism, and how to keep on point and not allow the subject to be highjacked by someone not wanting to talk about the issue at hand=================================Come support the work we're doing by becoming a Patron of ⁠⁠#BHN⁠⁠ www.patreon.com/BigHairyNews⁠=================================Merch available at www.BHNShop.nz Like us on Facebookwww.facebook.com/BigHairyNews Follow us on Twitter.@patbrittenden @Chewie_NZFollow us on BlueskyPat @patbrittenden.bsky.socialChewie @chewienz.bsky.socialEmily @iamprettyawesome.bsky.socialMagenta @xkaosmagex.bsky.social

Bowel Cancer NZ has called the changes to screening ‘a step backwards for health equity.'  Māori face 50% and Pacific peoples 63% higher death rates from the disease once diagnosed. Māori, in particular, are diagnosed with bowel cancer an average of 10 years earlier than the general population.The organisation says a standard screening age does not adequately address the increased risk that Māori and Pasifika communities face. Just one week earlier Bowel Cancer New Zealand presented proposals to the Health Minister -  detailing how parity with Australia – which screens from age 45 – could be fully achieved.  The proposals also outlined how to ensure equitable screening access for Māori and Pacific communities, who face bowel cancer risk a decade earlier. On Friday, Producer Evie spoke to Bowel Cancer NZ Chief Executive Peter Huskinson about the changes to screening and what impacts it will have on patients.

In this episode of Untidy, Matty and Hannah chat to Elise Johns, a rural mum of three, gym owner, personal trainer, and adventure racer who, at 37 years old and 24 weeks pregnant, was diagnosed with stage three bowel cancer. *Trigger warning: While Elise’s story has a happy and triumphant ending, baby loss is discussed, so please listen when the time is right and seek support if needed. Elise’s story is one of heartbreak, resilience, advocacy and grit. She shares her experience of navigating the grief of losing a baby at 19 weeks. Then, with her next pregnancy, Elise had to push for a bowel cancer diagnosis when doctors dismissed her symptoms. Elise battled through chemotherapy while pregnant until giving birth, underwent surgery, and had further chemotherapy. Then, she decided to enter the Coast to Coast to inspire her recovery and comeback. Elise talks about the importance of advocating for your health, the lessons she’s learnt about stress and resilience, gratitude, and why she’s more determined than ever to make the most of life. This episode is raw, inspiring, and full of important takeaways about grief, health, advocacy, and the power of the human spirit. Link mentioned in the show:- Amuri Ranges Run school fundraiser event- Bowel Cancer NZ — Elise’s story- Follow Elise Johns on Instagram If you’re enjoying Untidy, the best way to show your support is by tapping the ‘+ follow’ button in your podcast app and subscribing on YouTube! That way, fresh episodes will always be ready and waiting for you. Help us to keep building this supportive community — share an episode with a mate, and chuck us a 5-star review — it helps more people find our Untidy, unfiltered, and relatable chats. Thank you for listening, contributing and supporting this independent production! We’re grateful to have you here! — Hannah & Matty xx Don’t forget! Untidy is made for YOU — the people right at the heart of this steaming hot mess! Follow the show and DM us on Instagram @untidypodcast or email hello@untidypodcast.com. Your stories and ideas to help shape the show! Find us online at Untidy podcast. Find Matilda at @matootles and get your copy of The Feel Good Guide. Find Hannah at @hannahedavison and her My Big Moments children’s books at @mybigmoments. Enter code UNTIDY at checkout for 10% off your order.See omnystudio.com/listener for privacy information.

The Health Minister says higher testing rates are key to better bowel cancer outcomes. The Government is lowering eligibility for free screening to 58 from late this year. It's using funding set aside from the previous Government's plan to lower screening for Māori and Pasifika - who have worse early onset death rates - to 50. Simeon Brown says this will save more lives - but he explained they'll still pay attention to those communities. "We're also going to be doing a lot of work with Health NZ to focus on increasing the rates of testing amongst those Māori and Pasifika communities." LISTEN ABOVESee omnystudio.com/listener for privacy information.

A Clare cancer survivor is calling on her local community to go all in against cancer for the Irish Cancer Society's Daffodil Day. The Irish Cancer Society's annual fundraiser takes place on Friday, the 28th of March. Mary Woods, who hails from Newmarket-on-Fergus, knows a thing or two about cancer, having survived both womb and bowel cancer. Mary has been a Daffodil Day community organiser in her hometown for many years. Alan Morrissey spoke with Mary about her own story, the work done by the Irish Cancer Society, and Daffodil Day... Photo (C): Kuldeep Hunjan from Getty Images via Canva

Experienced nurse Claire Coughlan, clinical lead for Bowel Cancer UK, presents the NASGP's second webinar given at 1pm on Thursday 6 February.The main aims of the talk were to give an overview of:-Bowel cancer and the red flag symptoms.-Use of qFIT in symptomatic patients.-The bowel cancer screening programme.-The diagnostic pathway.-Lynch Syndrome.-Bowel Cancer UK support services for GPs and patients.Claire Coughlan is a consultant nurse in colorectal cancer with expertise in bowel cancer follow-up, genetics and symptom assessment. Claire is currently undertaking a PhD in the priorities for bowel cancer follow up care across diverse communities.#TeamGP #BowelCancer #PrimaryCare

Lucie Morris-Marr was a fit and healthy 44 year old, mother of two when she received a shock diagnosis of invasive stage four bowel cancer. She had no family history, was a non smoker, had a varied diet, a good weight and wasn't a heavy drinker. Lucie had just published her first non fiction book into the secret trial and conviction of Australian Catholic Cardinal George Pell. As her treatment began, all publicity events for that book were cancelled, and she defaulted to her journalistic instincts - digging deeper into other possible links to bowel cancer. What she discovered was a wealth of scientific studies linking regular consumption of processed meats with bowel cancer. Her new book Processed, draws on this science, and her own experience, to make the case for much better understanding of the risks to human health from processed meat.

People referred to the public health system gastro departments for colonoscopies or other exams are waiting months for an appointment even when they have symptoms that could be a sign of bowel cancer or other disease. Checkpoint has spoken to people experiencing worrying symptoms who are waiting for a colonoscopy or gastroscopy, while hearing nothing from Health New Zealand. Health NZ has told us it has staff recruitment drives, along with other ideas under way, to cope with an increase in gastro referrals. Jimmy Ellingham reports.

Bowel cancer is the fourth most common cancer in the UK, and experts believe poor diet is behind half of all cases. 肠癌是英国第四大最常见的癌症，而专家认为引起一半肠癌病例背后的原因都是不健康的饮食习惯。 Researchers at Oxford University, funded by Cancer Research UK, looked at data from more than half a million UK women over more than 16 years. It found that those with an extra 300 milligrams of calcium in their diets, equivalent to a large glass of milk a day, had a 17% lower risk of bowel cancer. 牛津大学研究人员在英国癌症研究基金会的资助下对 50 多万名英国女性在超过 16 年间的医学数据展开了研究。研究发现，每天在饮食中额外摄入 300 毫克钙的人，即等同于每天多喝一大杯牛奶，患肠癌的风险降低了 17%。 Researchers also said dark, leafy greens, white wholemeal bread and some non-dairy milks, which contain calcium, also had a protective effect. 研究人员还表示，同样含钙的深色绿叶蔬菜、全麦白面包以及部分种类的非乳制牛奶也具有一定的保护效果。

Dr Anisha Patel is a GP specializing in women's health whose world was turned upside down with a diagnosis of stage three bowel cancer. She's the author of the brilliant book Everything You'd Hoped You'd Never Need To Know About Bowel Cancer. I found this such a powerful book, with lessons for all of us whether or not we have cancer. This is a very inspiring conversation about women's health and how we can all take better care if ourselves. We talk about: - Anisha's cancer journey - How she found the strength to write her book - Vulnerability and the emotional aspects of cancer - Openness about one's health with children and family - The long-term effects and life after cancer - Surviving the survival - Psychosocial impacts and support - Anisha's work with charities to set up a life after cancer clinic to provide specialized support - Histamine intolerance and menopause - Balancing hormone therapy and histamine intolerance - Empowering women with knowledge And lots more! If you enjoyed this episode, please subscribe, share it and leave us a 5* review on iTunes or wherever you're listening. Order the ebook or audiobook (narrated by Rachel) versions of Rachel's book, Magnificent Midlife: Transform Your Middle Years, Menopause And Beyond at magnificentmidlife.com/book The paperback can be purchased on Amazon or other online retailers: UK: https://www.amazon.co.uk/Magnificent-Midlife-Transform-Middle-Menopause/dp/173981150X/ US & Canada: https://www.amazon.com/Magnificent-Midlife-Transform-Middle-Menopause/dp/173981150X/ Australia: https://www.amazon.com.au/Magnificent-Midlife-Transform-Middle-Menopause/dp/173981150X/ You can listen to all the other episodes and get the show notes at magnificentmidlife.com/podcast. Recommended by the Sunday Times. Feedspot #3 in best midlife podcasts and #14 in best women over 50 podcasts worldwide. You'll find lots of strategies, support, and resources to help make your midlife magnificent at magnificentmidlife.com. Check out Rachel's online Revitalize Experience, a 6-week intensive small group mentoring experience or 1-1 Midlife Mentoring.

An audio version of the bowel cancer screening leaflet sent with invitations to eligible people. A transcript of this episode is available on our website - https://www.gov.uk/government/publications/bowel-cancer-screening-benefits-and-risks/audio-transcript-your-guide-to-nhs-bowel-screening-podcast Contact us: england.vaccinations-screening-communications@nhs.net

February marks the start of 'Move Your Butt for Bowel Cancer' month - an awareness movement designed to encourage people to think about the condition. Colorectal cancer is the most commonly registered cancer in New Zealand, with thousands of cases diagnosed per year. Naturopath and wellness expert Erin O'Hara explains the importance of getting checked regularly - and eating a healthy diet to keep harmful effects at bay. LISTEN ABOVESee omnystudio.com/listener for privacy information.

In this week's episode we speak with the author of a new book, Processed, about the downside of sandwich ham and salami, fried bacon, hot dogs, pepperoni pizzas and the like. Speaking with GW deputy editor Greg Callaghan, Morris-Marr explains how a raft of scientific papers link the nitrites used in many processed meats to improve flavour and eliminate bacteria, with cancer. She explores, too, why so many of us ignore such warnings.See omnystudio.com/listener for privacy information.

We're giving you A Little More by revisiting some of the best moments from our Season One guests. Today Hugo tells us his incredible story on surviving both testicular and bowel cancer. Produced by headon.agency

Cancer has long been considered a disease that is usually suffered by the elderly, but a study found an increase in the number of sufferers among young people. - Selama ini penyakit kanker dianggap sebagai penyakit yang biasanya diderita oleh orang lanjut usia, namun dalam sebuah riset ditemukan kenaikan angka penderita di kalangan kaum muda.

Palmerston North Hospital is cutting back on some of its bowel cancer screening procedures, and Health New Zealand is unable to say if this is happening in other regions around the country. 852 patients who are at a high risk of developing cancer are on the waiting list for a colonoscopy in Palmerston North. Professor and Medical advisor at Bowel Cancer New Zealand Frank Frizelle said this will result in people having cancer who otherwise would not. LISTEN ABOVE. See omnystudio.com/listener for privacy information.

Bowel Cancer New Zealand is warning that ending critical cancer screening programmes for people under 60 will cost lives. Bowel Cancer NZ chief executive Peter Huskinson spoke to Corin Dann.

Bowel cancer rates in England have soared among under-50s - leaving experts concerned. New studies suggest more adults are developing early-onset bowel cancer worldwide, with figures across New Zealand, Chile, and Puerto Rico spiking annually. UK correspondent Enda Brady puts this increase down to processed food and unhealthy diets becoming more common. LISTEN ABOVESee omnystudio.com/listener for privacy information.

Some bowel cancer patients are missing out on a publicly funded cancer drug because their tumour is on the wrong side of their body and they have a specific genetic mutation. Ellen O'Dwyer reports.

In this episode, we explore findings from a groundbreaking study recently published in Nature which revealed potential targets for bowel cancer prevention and treatment. The study provides the most detailed understanding yet of bowel cancer's genetic makeup. The research, which used data from the 100,000 Genomes Project identified over 250 genes that play a crucial role in the condition, driver genes and potential drug targets. Our guests discuss the potential impact of these findings on patient outcomes, screening for bowel cancer, and future prevention strategies. Helen White, Participant Panel Vice-Chair for Cancer at Genomics England is joined by Professor Ian Tomlinson, Professor of Cancer Genetics at the University of Oxford, Claire Coughlan, Clinical Lead for Bowel Cancer UK and consultant nurse in colorectal cancer, and Dr David Church, a clinical scientist fellow and a medical doctor specialising in oncology at Oxford University. "The people that were kind enough to donate samples to the 100,000 Genomes Project, they did so knowing that they almost certainly wouldn't benefit personally from their donation from their gift and that any benefits would be some way down the line and hopefully benefit others which is what we're seeking to realise now. But, you know, it's not a given when we treat people in the clinic so we're very, very grateful to those individuals." You can read more about the study in our colorectal cancer blog and our study findings news story. You can download the transcript or read it below. Helen: Welcome to Behind the Genes. Ian: One of the great hopes is that some of these new genes that we've found could be useful in preventing cancer and it doesn't necessarily matter that they're rare, even if they're only 1% of cancers, by using those and changing those in the normal individual before they have had cancer then we may be able to reduce that risk. So, there are lots of potential new targets for prevention that are coming through.  My name is Helen White and I'm the Participant Panel Vice-Chair for Cancer at Genomics England. Today I'm delighted to be joined by Professor Ian Tomlinson, Professor of Cancer Genetics at the University of Oxford, Claire Coughlan, Clinical Lead for Bowel Cancer UK and consultant nurse in colorectal cancer, and Dr David Church, a clinical scientist fellow and a medical doctor specialising in oncology at Oxford University.   Today we will be discussing a pioneering colorectal cancer study which using data from the 100,000 Genomes Project has uncovered new insights that could transform diagnosis and treatment for patients with bowel cancer. If you enjoyed today's episode we would love your support, please like, share and rate us on wherever you listen to your podcast.  Thank you for joining me today. We're going to be discussing the findings from a landmark study that has been published in nature. This study used data generously donated by people with bowel cancer who took part in the 100,000 Genomes Project giving us the most detailed look yet at the genetic makeup of colorectal cancer better known as bowel cancer. But before we get into that let's start by hearing from my guests. Could each of you please introduce yourselves.  Ian: I'm Ian Tomlinson, I work at the University of Oxford and most of my work is research into bowel cancer, it's genetic causes, the genes that are involved in actually causing the cancer to grow which may be different from genetic causes and also the use of that data to help patients whether guiding future treatments or potentially helping to prevent bowel cancer which would obviously be our optimum strategy to have the biggest impact on the disease and its incidents.   Claire: So, I'm Claire Coughlan, I'm the clinical lead for Bowel Cancer UK and my remit at the charity is to ensure that everything we do is clinically relevant and that we're providing services that meet the needs of those affected by bowel cancer and the educational needs of those health professionals that work with people affected by bowel cancer. I'm also a nurse consultant in colorectal cancer at Lewisham and Greenwich NHS Trust and I lead an urgent referral service there and also work with patients with late effects of bowel cancer.  David: I'm David Church, I'm a medical oncologist and Cancer Research UK advanced clinician scientist at the University of Oxford. I treat bowel cancer clinically and do research on bowel cancer and womb cancer including a lot of research using samples and data from Genomics England data service we're discussing today of course.  Helen: Great, thank you. Now let's turn to Claire to learn more about bowel cancer. Claire, can you share with us how common it is, how treatable it is and if there are any trends in terms of which groups of people are affected?  Claire: Of course, bowel cancer is a relatively common cancer, there are about 46,000 people each year in the UK diagnosed with bowel cancer so that is quite a large number. The thing that really drives us forward in bowel cancer is that the earlier stage you're diagnosed at the greater chance of survival. So, the figures for that are quite stark, we stage bowel cancer through stage one to 4 with one being the earliest stage and 4 being the most advanced.   If you are diagnosed with bowel cancer at stage one you have a 9 in 10 chance of being alive and well 5 years after your diagnosis of bowel cancer. And if you're diagnosed at the other end of the spectrum at stage 4 that drops to a 1 in 10 and should people survive after a diagnosis of stage 4, which more people than before do they will have had a lot of treatment for their bowel cancer so the burden of the treatment will also be with them after that. So, it's really important that we diagnose at the earliest possible stage which is why studies such as the one we're going to talk about today are so important.   We have noticed that there has been a slight increase in being diagnosed at a younger age. That said the latest statistic is 2,600 people were diagnosed under the age 50 in the UK last year so it's still a disease of older people, you still have a greater chance of getting bowel cancer as you get older but it's really, really important that we're aware that you can still get bowel cancer as a younger person.   Probably one of the most exciting things that has happened for bowel cancer of recent years is our bowel cancer screening programme and the age for that now has been brought down to 50, we're not quite there all over the country, but in the UK that is the aim that everyone will be screened for bowel cancer at the age of 50. So, yes it's a common disease and staging an early detection is vital. Helen: That's lovely Claire, thank you very much for that. David, turning to you could you please explain to us how bowel cancer typically develops? David: Yes, so we know compared with many cancer types quite a lot about how bowel cancer develops because the bowel is accessible to collect samples by a technique called endoscopy which is putting a camera into the bowel from which you can sample tumours or lumps. And so from genetic research done in the last 10 years we know that, or we've known for many years actually, for much longer, that cancer is a genetic disease, it's a disease caused by alterations in genes and particularly genes that control whether the cells in our bowel grow normally and die normally as they should do. And collectively when there are alterations in genes that regulate those processes you can have a cell or collection of cells which are able to grow without restraint and don't die when they should do which are some of the hallmarks of a cancer and they also require the ability to spread elsewhere in the body which is what kills people with cancer including bowel cancer. We know from research done in the last 10 to 15 years that some of the alterations in genes that can cause bowel cancer in combination occur very early in our life, even in the first and second decade of life, but don't cause cancer. The earliest detectable abnormality is typically a polyp which is a tumour, a lump within the bowel which is detectable and if removed is almost certainly cured by removal alone but if it's not detected then as that grows and acquires more alterations in genes then it can become a cancer and cancers develop the ability to invade the bowel wall, to spread to what we call lymph nodes or glands nearby and also to spread further afield, most commonly to the liver or to the lungs.   And for most people whom bowel cancer has spread to the liver or to the lungs or elsewhere unfortunately we're not able to cure their disease which as Claire has said is why there is such an importance in detecting cancers and pre-cancers as we call them so that the tumours are not actually cancerous but come before bowel cancer as early as possible.  Helen: Thank you David. Moving on to the study, Ian perhaps you can take this, in the study that you carried out my understanding is that the whole genome sequencing was used to investigate the genetic changes that lead to the development and growth of bowel cancer. And for this participants with bowel cancer in the 100,000 Genomes Project donated both a blood sample and a tumour sample while those with rare conditions only provided a blood sample, can you explain why that is?  Ian: As you said the study really looked at 2 quite separate arms albeit with a little bit of overlap as we'll see. So, one very important aim was to look at individuals, both children and adults, who had medical problems or other conditions that were unexplained but which had some features that suggested that they weren't necessarily inherited but there may be some variation in their genes that had caused them, and roughly half of the programme was dedicated to that.   Within that there was a small number of people who had a strong family history of bowel cancer or who had large numbers of polyps in the bowel and they were analysed in a separate part of the project from what we're mostly discussing. Within the cancer arm there was a collection really throughout England of patients who had most of the common types of cancer and a few with less common cancers.   And because when we're looking at genetic and related changes in cancers we need to make sure that those changes have actually occurred in the cancer as it started growing from its earliest stages with a small number of cells in the body that were slightly abnormal and then progressing. We need to look at what genetic variation the patient has in all the cells of their body. We don't want to look at patients and say that looks an interesting change, we may be able to use that if it's present in all of the normal cells in that patient's system.   We want to make sure the change is specific to the cancer itself and therefore we have to sequence both a sample probably taken from blood and a sample taken from the actual cancer. And in a way we subtract out the changes in the blood to identify the changes that have actually occurred in the cancer itself.  Helen: That's a very helpful explanation. Does this research show that there is a role for whole genome sequencing in clinical care?  Ian: I think my own view is it is all a question of cost. I think the advantages it provides it can assess multiple types of genetic change at once. It is relatively consistent across each cancer's genome between cancers, even between centres mean that it is the method of choice. There are undoubtedly developments that will happen in the future, maybe being able to sequence longer stretches of DNA in one go that will help the analysis.   And some of the computational methods are likely to develop to identify some of the slightly difficult to identify genetic changes but it ought to be the standard of choice. There are issues and potential difficulties in collecting the high-quality samples that have been needed from pathology laboratory and that will be difficult going forward with current budges and there are lots of challenges but ultimately it in some form has to be the method of choice. What wasn't done is to look at other molecule tests or essays, looking at RNA wasn't really done on a big scale as well as DNA and other changes to DNA apart from the genetic changes were not looked at.   So, there are certainly ways it could be improved if you had limitless money but I think the project, 100,000 Genomes has shown the whole genomes are. They have a lot of advantages and ultimately probably will be adopted by the NHS and similar organisations.  Helen: David, could you now tell us about the findings of this pioneering study and what impact these findings might have on people with bowel cancer in the future?  David: So, this is the largest study to date to analyse the entire genome of bowel cancer by some margin and the fact that we've done whole genome sequencing and in so many people it has really given us an unprecedented ability to identify the genetic alterations that drive bowel cancer. And within bowel cancer we've known for some time it is not a homogeneous entity that bowel cancer is not all created equal, that there are sub-groups of bowel cancer and we have been able to refine those over previous efforts. And I guess if you were to ask what the biggest take home for me from the study is it's just the complexity of the disease.   So, as we've mentioned we know that cancer is a genetic disease, that it's driven by genetic alterations, alterations in genes which regulate the growth of cells or the death of cells or the spread of cells. And we've known for many years that there is a modest number of genes which are commonly malfunctioning in bowel cancer and they would be in the tens to dozens really. But with this work we've hugely extended our understanding of the genes that drive bowel cancer and in fact we've discovered nearly 250 genes which are altered in bowel cancer and appear to drive the growth of the cancer.   Now we know that not all of those will be validated and by that I mean that there are associations that we find at the moment, not all of which will be biologically relevant but interpreted in the data we know a large number that are previously undiscovered are or we can be fairly confident of that. And one of the take homes from that is that many of these are only altered in a small fraction of bowel cancers.   So, rather than being perhaps half of bowel cancers or a third of bowel cancers there are a good number of genes, a very substantial number of genes, which are altered in say 3 to even 1% of bowel cancers. And if we think about how we go about targeting those and perhaps we'll come onto treatment later that poses really challenges for how we work and we would think about treating patients with bowel cancer who have those particular alterations in their cancers.  Helen: Thank you David, yes we'll come onto treatment shortly, but I think Claire has a question for you.   Claire: Yes, thank you. For me as somebody who works in this every day this is such an exciting and interesting study, particularly in light of what we said earlier about early detection and how critically important that is for improving outcomes in people with bowel cancer. So, in your view do you think this research could help shape future screening programmes or prevention strategies?  David: That's a great question, I suppose in terms of screening at the moment the majority of screening is done in the UK at least by testing for blood in the stool which is relatively non-specific so I'm not sure that that would be directly impacted by this research. But one area of early cancer detection that is perhaps more relevant is quite a lot of work including from Oxford actually in recent years looking at blood tests. So, testing blood samples for early detection of cancer whereby you can test for genetic alterations, fragments of DNA that have alterations from the bowel cancer or any cancer that circulates in the blood and that tends to rely on a small number of common alterations.   And with this data I could see that we might be able to refine those tests and in so doing improve our early detection of cancer but that would need quite some work before we could actually say look that had real potential I think. And in terms of prevention there are, I think Ian may want to come in on this, one or 2 sub-groups which you might think that you could try to prevent but of course that needs a lot of extra work really.   But I think we have some clues of the biology of bowel cancer and particularly some of the sub-groups where you might think well this drug would work better in terms of preventing that sub-group or that sub-group but that will need to be the subject of future study.  Helen: Ian, did you want to come in on that at all?  Ian: So, at the moment prevention is a fairly new way of helping to reduce the number of people with bowel cancer at the level of the whole population which is what we have in the UK above a certain age group as we heard from Claire earlier. The methods used, again as we heard, are screening for occult blood in the stool and then colonoscopy to identify either hopefully early cancers or polyps and remove those. But when we think about the methods that we use for preventing other diseases then normally where they're successful using a more easily delivered and I have to say less expensive method.   So, high blood pressure is treated to reduce the risk of cardiovascular disease and there are other diseases where those what you might call molecularly-based prevented strategies are coming in. We really lack that for bowel cancer in particular, it does happen for some other cancers, but one of the great hopes is that some of these new genes that we've found could be useful in preventing cancer. And it doesn't necessarily matter that they're rare, even if there are only 1% of cancers, by using those and changing those in a normal individual before they have had cancer then we may be able to reduce that risk.   So, there are lots of potential new targets for prevention that are coming through and as David said it is going to take a lot of work to work out which of those are deliverable and who will benefit. But we have quite a lot of opportunities in that space and although that may not be us that takes that forward, it may be, but it may not be. We think it is a lot of material for those interested in chemo prevention using drugs of cancer that they can work on and with luck deliver some new ways of preventing cancer that may be simply popping a pill every morning to take your risk right down to as close as zero as we can.  Helen: Thank you Ian. David, I think you had something to add here.  David: Thanks Helen. One area of prevention that we're really interested in Oxford and many others are is using the genetic alterations that we find in bowel cancers and other cancers as targets for vaccination. Now we know that gene alterations will cause abnormal proteins which while they might drive the cancer, make it grow or not die, can also be recognised by the immune system so the abnormal proteins can be recognised by the immune system as being foreign and as foreign they can be targeted by the immune system so the immune system will try and kill the cells carrying those alterations. And we know for some sub-sets of bowel cancers those alterations can be relatively predictable actually, they occur in quite a sizeable fraction of some sub-groups of bowel cancers.   And one area that we're particularly interested in at the moment and actively pursuing is using those targets where you need some additional work to demonstrate when they are particularly recognisable by the immune system. But to use these genetic alterations is potential targets for vaccination with the intention ultimately of preventing bowel cancer in at risk individuals or ideally in the full-term time the whole population. And we've received some funding from Cancer Research UK to pursue this line of research and we have a group working on this in Oxford and as I say many others do elsewhere.  Helen: Thank you David, yes I have a vested interest in this because my understanding is this work is aimed primarily at people with a genetic condition called lynch syndrome which predisposes the people who have inherited this gene change alteration to bowel cancer, womb cancer and other cancer. And I had womb cancer, as I think David you know, a few years back and discovered it was due to lynch syndrome and so it's really exciting that you're now looking at vaccinating preventing because yes I take aspirin every day, I have my colonoscopy every 2 years which have some effect on preventing these cancers but it's not 100% guaranteed. And I don't suppose it ever will be but having the vaccination in that armoury would be fantastic I think for future generations, it's very exciting and we look forward to hearing more about it.   Thank you Ian and David. I mean we've heard a lot there about preventing bowel cancer but I think moving back now to potential treatments, you know, we've heard from David how this study has shown a number of actionable findings but what are the next steps towards treatment? How can these findings be turned into real actions that will benefit those people diagnosed with bowel cancer in the future? Ian, perhaps you would like to pick up on this to start.  Ian: That step is one, you know, in which I'm not personally an expert but a lot of the newer treatments are based on the finding of so called driving mutations which are simply genetic changes that occur as the cancer grows and contribute to that growth and ultimately if it's not treated to the spread and dissemination of a cancer. And the fact that we have reported 250 which need validation but of which a large proportion are likely to be true drivers means that anyone of those can be a potential new target.   The criteria to be used for which of those mutations to pursue, which of those driver genes to chase up are quite complicated normally, depend on many things such as the interest of research groups and small and larger drug companies. And the similarity of those genes to other genes that have evolved and the processes that they make to go slightly wrong in the cancer.   So, there is also the issue that because these are uncommon, everybody talks a lot about personalised medicine or precision medicine, this would be truly precision or personalised medicine because a genetic change that was driving the cancer in only 1% of patients is obviously not a huge number of patients although bowel cancer is a common cancer so it's not a tiny number either. But it would mean investment at that level to benefit let's say 1 to 2% potentially of all patients with bowel cancer but I think that's a nettle we have to grasp. And I think our results are showing that most of the really common drug changes either have not yet been successfully targeted in treatment or are too difficult to target.   So, we're going to have to start looking at these less common genetic drivers and design strategies, inhibitors, you know, again that can be delivered to patients relatively straightforwardly in order to see whether they benefit the patients concerned. But there is this problem of getting enough patients enrolled in clinical trials where a change is only present in a relatively small proportion of all the patients with that cancer type.   Helen: Thank you Ian. Presumably if there is a relatively small number of patients the people who are looking at running these trials might be looking at perhaps international trials, would that be one way to go?  Ian: So, I think David can speak with more personal knowledge but there are international trial networks and there are collaborations along these lines already under way. I would hope that those could be made use of even more than they are already. There is, you know, a financial consideration for those developing new anticancer treatments which are, you know, high risk work and also the costs of setting up trials and enrolling people is not a trivial thing. So, I think those are hurdles that can be overcome but it would need a concerted effort to do that. Patients will play a major role in that and patient organisations as well as 100,00 Genomes and other similar projects.  Helen: Yes, thank you, David I don't know if you want to come in on that.  David: Yes, the challenge of testing therapies in small groups is a very real one and there is lots of interest at the moment in exploring alternatives to conventional clinical trials. And as we use more electronic patient records and we have pharmacy records so there is the potential to get those data from routine clinical practice and there is lots of investments and attention on that at the moment so called real world data which is always an interesting term as if patients in clinical trials aren't in the real world which of course they are.   But it's perhaps a little more cost effective sometimes in clinical trials, of course it does pose its own challenges in how you disentangle true treatment effect from other factors because there are many factors impacting on how long people with cancer live. But there is a lot of investment and effort going into that at the moment and it will be interesting to see how that develops over the coming years.  Helen: Turning to you Claire based on your experience how well do you think people with bowel cancer understand how genomes can help with their care and what support is currently available to them in this area?  Claire: I think the answer, as it is so often is, it's dependent on individuals and not just one individual. So, I think some patients are very motivated to know as much about this as possible and to understand and to know what the next steps may be in their own treatment that may be helped by this. Others don't want to have the same knowledge and want to be guided very much by their medical teams but I think oncologists obviously are at the forefront of this and we see at the charity … we have services at the charity that supports patients and we see lots of queries into our ask the nurse service where people have been given variable information about I suppose personalised medicine as Ian alluded to and how their very specific bowel cancer may be treated, so I think it varies from patient to patient.   There is support available so we have the ask the nurse service I alluded to. We have a brilliant patient forum actually and everybody in clinical practice will have seen this, patients often become more expert than anybody and they share advice and they're moderated forums that are a very safe place for people to ask questions where there is a moderator to ensure that it is made really clear that circumstances are individual.   And the same with the ask the nurse service because you don't have all the clinical information so it is about empowering people, so there is support available. I think the other thing that is really important is equipping specialist nurses with the knowledge that they need to support their patients. This is a really exciting area of evolution for bowel cancer particularly I think in all cancers at the moment but for bowel cancer I think things have changed fairly rapidly in recent years and specialist nurses really need support in knowing that they have up-to-date information to give their patients.   So, that's another challenge for us and any specialist nurses that might be listening to this podcast we have online education on genomics for specialist nurses. Just while we're talking about that and you mentioned lynch syndrome earlier, so there has been a lynch syndrome project as I'm sure you're aware where we're trying to get testing for lynch syndrome brought into local hospitals.   So, there was some funding via NHS England so that the testing be done at time of diagnosis, so a pre-test and then a final test if that's appropriate, for everybody diagnosed with bowel cancer to see if they have lynch syndrome. And in some trusts that has been done and in others it hasn't yet and the funding hasn't quite followed in the way that we need it to enable that to happen. It's vitally important, we think there are about 175,000 people in the UK with lynch syndrome and we only know about 5% of them. And this is a gene change that is an inherited gene change so we can do what we call cascade testing where we test family members and we can then employ preventative strategies to prevent people from developing bowel cancer.   So, it's a really important project, so I think as well as supporting patients with the information around the changes that are happening in this area we also need to ensure that we support the workforce and have investment there to enable the support of all the changes and the genomic landscape.  Helen: Absolutely Claire and so much resonates there with what you've said. Having myself had cancer discovered that was due to lynch syndrome, cascade testing offered to my family members so valuable. It turns out I inherited my change from my mum who is 83, has never had cancer, so I think that's a very good example of, you know, it doesn't necessarily mean that you will get cancer but actually on that point that you made about empowering patients I always have a right smile because there is my mum going off to all her other medical appointments because at 83 she sees quite a few people and she is always the one telling them about lynch syndrome and educating them because most of them haven't heard of it, so yes it's really, really important.   And that patient forum, you're probably aware of Lynch Syndrome UK, I don't have any involvement in that other than being a member but that is so valuable for people with a particular condition to go somewhere where they can talk to or listen to other people with a similar condition, really, really valuable.   Right, well I think circling back really to the 100,000 Genomes Project I think you touched on this earlier David but reflecting on what you and Ian have told us about your study what is it about the 100,000 Genomes Project bowel cancer dataset that made this work possible?  David: There are a few things, one of which and not least of which is the sheer size of the effort. So, to have whole genome sequencing for more than 2,000 individuals is previously unprecedented and we'll be seeing more of this now as we scale up our research efforts but at the inception of the project it was very, very ambitious and to be able to deliver that is a huge achievement. And the quality and breadth of the analysis is very strong as well.   And ultimately, you know, the former gives thanks to the people that were kind enough to donate samples to the 100,000 Genomes Project, they did so knowing that they almost certainly wouldn't benefit personally from their donation from their gift and that any benefits would be some way down the line and hopefully benefit others which is what we're seeking to realise now. But, you know, it's not a given when we treat people in the clinic so we're very, very grateful to those individuals.   And I think also to the scientists who worked incredibly hard over the last 5 years to deliver this work actually. So, having been part of the team and being lucky enough to be part of the team along with Ian we've had hugely motivated individuals that really have dedicated a large fraction of their working lives to delivering this project which I think is a fantastic achievement as well.  Helen: Thank you, thank you to all those participants who at a time when their lives probably were turned completely upside down by a cancer diagnosis were offered the chance to join the 100,000 Genomes Project and said yes. As you say most of them will have known that it won't have helped them but by donating their data, you know, it has allowed this work to happen and potentially it could change lots of people's lives in the future, so thank you to them.  Ian: Could I also just emphasise and agree with what David has said, I won't go through all the individuals by name, but if anybody wants to read the published report of the work there are several people on there, Alex Cornish is the first author, but many colleagues from an institute of Cancer Research, The University of Manchester, Birmingham, Leeds, other universities in London that all contributed, but also colleagues in the NHS and/or universities who recruited patients, collected samples, processed them etc and of course the people who did the preparation of the samples in genetics laboratories and actually did the sequencing and basic analysis too.   So, it is a truly huge effort across particularly all the cancer types which is particularly a complex collection given the fact the tumour is needed and a blood sample. It's quite difficult in a way to find a formal way of thanking them for all of this but without them it wouldn't have happened.  Helen: On that note I think we'll wrap up there. A huge thank you to our guests, Professor Ian Tomlinson, Clare Coughlan and Dr David Church for an enlightening discussion on the groundbreaking study published in nature. This research is set to reshape our understanding of colorectal cancer and pave the way for new possibilities in treatment and patient care.   If you would like to hear more like this please subscribe to Behind the Genes on your favourite podcast app. Thank you for listening. I have been your host, Helen White. This podcast was edited by Bill Griffin at Ventoux Digital and produced by Naimah Callachand. 

Episode 89 - Brand Strand and Founder Story - Raphaela Reeb, UK Health Radio's Creative Director and ‘Stoma4Life' Radio Show and Podcast Host on Bowel Cancer and Destigmatizing ‘Life as an Ostomate'. Disclaimer: Please note that all information and content on the UK Health Radio Network, all its radio broadcasts and podcasts are provided by the authors, producers, presenters and companies themselves and is only intended as additional information to your general knowledge. As a service to our listeners/readers our programs/content are for general information and entertainment only.  The UK Health Radio Network does not recommend, endorse, or object to the views, products or topics expressed or discussed by show hosts or their guests, authors and interviewees.  We suggest you always consult with your own professional – personal, medical, financial or legal advisor. So please do not delay or disregard any professional – personal, medical, financial or legal advice received due to something you have heard or read on the UK Health Radio Network.

Kellie Finlayson shares her inspiring story with Ant in this episode. The young Mum and wife of AFL star, Jeremy Finlayson, was just 25 when she was diagnosed with terminal bowel cancer in 2021. Having just given birth to Sophia, she put some unusual symptoms down to being postpartum, but the results of a delayed colonoscopy revealed the life-changing news.  She opens up about how this robbed her of her first year of motherhood, the ongoing fight to stay alive each day, and how the support of her family and friends kept her going. LINKS Find out more about prevention and early detection of bowel cancer at jodileefoundation.org.au Follow Kellie Finlayson on Instagram @kelliefinlayson_ Follow Ant on Instagram, X, and Facebook Learn more about Ant on his website antmiddleton.com Follow Nova Podcasts on Instagram for videos from the podcast and behind the scenes content – @novapodcastsofficial. If you enjoy listening to Head Game, you can vote for us in the 'Listener's Choice' category at the Australian Podcast Awards. Submit your vote at australianpodcastawards.com/voting CREDITSHost: Ant MiddletonEditor: Adrian WaltonExecutive Producer: Anna Henvest Managing Producer: Elle Beattie Nova Entertainment acknowledges the traditional custodians of the land on which we recorded this podcast, the Gadigal People of the Eora Nation. We pay our respect to Elders past and present. See omnystudio.com/listener for privacy information.

Dogs are on their way to sniffing out early signs of bowel and ovarian cancers. K9 Medical Detection New Zealand has had a 100% success rate in recent trials. The four-legged workers are trained to detect specific odours connected to bowel and ovarian cancers. CEO Pauline Blomfield told Heather du Plessis-Allan that the dogs are clearly detecting the odour released from cancer, but they're not replacing any tests. She said that they're currently working with scientists to identify the markers dogs are picking up on, because they don't currently know what exactly the dogs are smelling. LISTEN ABOVE See omnystudio.com/listener for privacy information.

Send us a textEpisode 9 - Series (Season 2)After three weeks of wonderful guests Martin & Patrick are on there own for a catch up.Martin still doing well on his new Cancer treatment heads back for his 3 monthly check up and CT Scan.Its also good news as for the first time in nearly two and a half years Martin applies for a new Job, can you guess what it is yet all will be revealed.A new feature this week is guest Ian Trushell who is currently battling Stage 4 Bowel Cancer which has spread into the Liver.Bowel cancer is also called colorectal cancer. It affects the large bowel, which is made up of the colon and rectum. Cancer is when abnormal cells start to divide and grow in an uncontrolled way. The cells can grow into surrounding tissues or organs, and may spread to other areas of the body.Ian was given a two year life expectancy but he recently past that date and is continuing his battle with a positive mental attitude. Ian today describes the symptoms of Bowel and what to look out for.Oh no, yes Martin gets his Joke of the week in this week, not sure if its a winner.Next week we continue with our guests, Martin and Patrick attend the "Make a Wish Charity" awards ceremony and speak to some of the winning recipients.#Mediastinal Germ Cell Tumour#Prostate Cancer#Bronchiectasis#CharcotmarietoothDisease#Emphysema#The after life#Ghosts#Spirts#Ouija boards#Mediums#Psychics#Reincarnation#HeartTransplant#EbsteinsAnomaly#RareCondition#HealthJourney#LifeChangingDiagnosis#MentalHealth#Vulnerability#SelfCompassion#PostTraumaticGrowth#MedicalMiracle#BBCSports#Inspiration#Cardiology#Surgery#Podcast#Healthcare#HeartHealth#MedicalBreakthrough#EmotionalJourney#SupportSystem#HealthcareHeroes#PatientStories#CardiologyCare#MedicalJourney#LifeLessons#MentalWellness#HealthAwareness#InspirationalTalk#LivingWithIllness#RareDiseaseAwareness#SharingIsCaring#MedicalSupport#BBCRep#bbcuploadCheck out our new website at www.whostomanddick.comCheck out our new website at www.whostomanddick.com

This week's hot topic: A groundbreaking study has uncovered a potential link between a common childhood bug and an increased risk of bowel cancer later in life. In this weekly hot topic episode, I outline the research details, exploring how early-life infections could play a role in developing colorectal cancer. Learn about the biological mechanisms involved, the implications for long-term gut health, and what steps can be taken to mitigate risks.

In this special episode of The Mic Drop Club, host Douglas Hamandishe sits down with Briony Segal, a dedicated advocate for public health, to explore her crucial work in raising awareness about bowel cancer screening and the power of volunteering. As part of the Bowel Cancer UK Screening Service, Briony has been at the forefront of engaging communities, dispelling myths, and encouraging early screening, particularly in Medway and Swale. Briony shares her journey, from starting in public health initiatives to now leading community engagement projects for bowel cancer screening. She talks openly about the challenges of getting people to participate in screening, especially in hard-to-reach communities, and highlights the importance of trust, communication, and small conversations in raising awareness. In this episode, Briony covers: The importance of bowel cancer screening and how early detection saves lives. The barriers to health screenings in different communities and how to overcome them. Volunteering opportunities for individuals to become community champions and help spread awareness in their neighbourhoods. Heartfelt stories of survival and loss emphasise the need for more education and involvement in cancer screening programs. Briony's call to action is clear: she seeks community champions to continue her important work once the project concludes. If you have a passion for health advocacy and want to make a difference, this episode is for you! Interested in getting involved? Reach out to Briony at briony@mva.org.uk or visit MVA to learn how you can become a community champion, help raise awareness, and make a real impact in the fight against bowel cancer.  

The journey of coming back to your body and loving your own company with Angelica Alen  Angelica discusses how we often numb ourselves or live outside our bodies, and how vital it is to reconnect with ourselves. By noticing these tendencies and actively working on returning to our being, we can develop a stronger, more loving relationship with ourselves. Listen now to: The journey of coming back to your body and loving your own company with Angelica Alen.  This is an excerpt from our full-length episode, Conquering cancer, the art of surrender, and the power of radical ownership with Angelica Alen. Listen where you get your podcasts or watch on YouTube.  Link here: https://www.podbean.com/eas/pb-f97cy-1676051 ----more---- Welcome to The Afterlight Podcast with Lauren Grace, a spiritual podcast full of stories and conversations that prove we're never alone. Lauren Grace, is the host of The Afterlight Podcast, mindset and manifestation coach, and medium. With over two decades of experience in self-development and a passion for empowering soul-led entrepreneurs, Lauren's mission is to help you tap into your inner power so you can live the life you choose.   Connect with Lauren Grace, Lauren Grace Inspirations: Lauren on Social @LaurenGraceInspirations Website: https://laurengraceinspirations.com Join Soul Accelerator: https://laurengraceinspirations.com/soul-accelerator Want to work with Lauren? Book a Free Discovery Call with Lauren: https://laurengraceinspirations.com Free Offers: https://laurengraceinspirations.com/freeoffers   The Afterlight Podcast:  The Afterlight Podcast on Social @theafterlightpodcast To be a guest, apply here: www.theafterlightpodcast.com Sign up for our newsletter: https://laurengraceinspirations.com/contact   Meet Angelica My guest today is Business + Health Coach Angelica Alen. After conquering Stage 3 Bowel Cancer and completing 12 sessions of chemotherapy, feeling stronger than ever, Angelica founded her business to help people achieve optimum health and well-being regardless of their starting point. After successfully building a six-figure health coaching business from scratch, she recognized a common desire among her clients: to help others and create a meaningful impact in the world. This inspiration led her to expand her focus, assisting people in creating life on their terms and sharing their stories to help others heal and evolve as human beings. As a business and health coach, Angelica is dedicated to helping clients build thriving businesses while enhancing their health. Her goal is to guide clients in turning their purpose into a sustainable business that brings happiness and financial freedom. Her unique approach includes NLP to reprogram mindsets for success and habit science, as everything we do is a habit. She also incorporates energetic alignment to ensure energy and intentions align with the life being created. Website: https://www.angelicaalen.com/

Radical ownership and taking back your power through habits with Angelica Alen  We are a set of habits. In this mini-episode, Angelica shares how recognizing and owning our habits—whether they be anxiety, anger, or victimhood and more —grants us the power to change. By leaning into these emotions, we can transform our lives and reclaim our power. This is an excerpt from our full-length episode, Conquering cancer, the art of surrender, and the power of radical ownership with Angelica Alen. Listen where you get your podcasts or watch on YouTube.  Link here: https://www.podbean.com/eas/pb-f97cy-1676051 ----more---- Welcome to The Afterlight Podcast with Lauren Grace, a spiritual podcast full of stories and conversations that prove we're never alone. Lauren Grace, is the host of The Afterlight Podcast, mindset and manifestation coach, and medium. With over two decades of experience in self-development and a passion for empowering soul-led entrepreneurs, Lauren's mission is to help you tap into your inner power so you can live the life you choose.   Connect with Lauren Grace, Lauren Grace Inspirations: Lauren on Social @LaurenGraceInspirations Website: https://laurengraceinspirations.com Join Soul Accelerator: https://laurengraceinspirations.com/soul-accelerator Want to work with Lauren? Book a Free Discovery Call with Lauren: https://laurengraceinspirations.com Free Offers: https://laurengraceinspirations.com/freeoffers   The Afterlight Podcast:  The Afterlight Podcast on Social @theafterlightpodcast To be a guest, apply here: www.theafterlightpodcast.com Sign up for our newsletter: https://laurengraceinspirations.com/contact   Meet Angelica My guest today is Business + Health Coach Angelica Alen. After conquering Stage 3 Bowel Cancer and completing 12 sessions of chemotherapy, feeling stronger than ever, Angelica founded her business to help people achieve optimum health and well-being regardless of their starting point. After successfully building a six-figure health coaching business from scratch, she recognized a common desire among her clients: to help others and create a meaningful impact in the world. This inspiration led her to expand her focus, assisting people in creating life on their terms and sharing their stories to help others heal and evolve as human beings. As a business and health coach, Angelica is dedicated to helping clients build thriving businesses while enhancing their health. Her goal is to guide clients in turning their purpose into a sustainable business that brings happiness and financial freedom. Her unique approach includes NLP to reprogram mindsets for success and habit science, as everything we do is a habit. She also incorporates energetic alignment to ensure energy and intentions align with the life being created. Website: https://www.angelicaalen.com/

Angelica shares her incredible journey of transformation, where she turned life's challenges into powerful catalysts for change. After a cancer diagnosis, Angelica took radical ownership of her life, changing her physical, mental, and emotional habits during chemotherapy. Her story is a testament to the power of resilience and the importance of conscious living. In this mini-episode, Angelica talks about using life's challenges as a catalyst to change. This is an excerpt from our full-length episode, Conquering cancer, the art of surrender, and the power of radical ownership with Angelica Alen. Listen where you get your podcasts or watch on YouTube.  Link here: https://www.podbean.com/eas/pb-f97cy-1676051 ----more---- Welcome to The Afterlight Podcast with Lauren Grace, a spiritual podcast full of stories and conversations that prove we're never alone. Lauren Grace, is the host of The Afterlight Podcast, mindset and manifestation coach, and medium. With over two decades of experience in self-development and a passion for empowering soul-led entrepreneurs, Lauren's mission is to help you tap into your inner power so you can live the life you choose.   Connect with Lauren Grace, Lauren Grace Inspirations: Lauren on Social @LaurenGraceInspirations Website: https://laurengraceinspirations.com Join Soul Accelerator: https://laurengraceinspirations.com/soul-accelerator Want to work with Lauren? Book a Free Discovery Call with Lauren: https://laurengraceinspirations.com Free Offers: https://laurengraceinspirations.com/freeoffers   The Afterlight Podcast:  The Afterlight Podcast on Social @theafterlightpodcast To be a guest, apply here: www.theafterlightpodcast.com Sign up for our newsletter: https://laurengraceinspirations.com/contact   Meet Angelica My guest today is Business + Health Coach Angelica Alen. After conquering Stage 3 Bowel Cancer and completing 12 sessions of chemotherapy, feeling stronger than ever, Angelica founded her business to help people achieve optimum health and well-being regardless of their starting point. After successfully building a six-figure health coaching business from scratch, she recognized a common desire among her clients: to help others and create a meaningful impact in the world. This inspiration led her to expand her focus, assisting people in creating life on their terms and sharing their stories to help others heal and evolve as human beings. As a business and health coach, Angelica is dedicated to helping clients build thriving businesses while enhancing their health. Her goal is to guide clients in turning their purpose into a sustainable business that brings happiness and financial freedom. Her unique approach includes NLP to reprogram mindsets for success and habit science, as everything we do is a habit. She also incorporates energetic alignment to ensure energy and intentions align with the life being created. Website: https://www.angelicaalen.com/

Conquering cancer, the art of surrender, and the power of radical ownership with Angelica Alen. In this episode, Lauren and Angelica discuss the power of working with a coach, using life's challenges as catalysts for change, radical ownership, taking back your power through habits and NLP, the journey of reconnecting with your body, loving your own company, and much more. Angelica shares helpful tips and tricks to support you in living a wondrous life. After spending 38 years asleep, a cancer diagnosis woke her up to a new way of being and living. During chemotherapy, Angelica faced physical, mental, and emotional challenges that led her on a self-discovery and healing journey. Angelica transformed her life by taking radical ownership of her life and changing her habits.  Discover how embracing these powerful concepts can transform your life and empower you to face any challenge. Listen now.  ----more---- Welcome to The Afterlight Podcast with Lauren Grace, a spiritual podcast full of stories and conversations that prove we're never alone. Lauren Grace, is the host of The Afterlight Podcast, mindset and manifestation coach, and medium. With over two decades of experience in self-development and a passion for empowering soul-led entrepreneurs, Lauren's mission is to help you tap into your inner power so you can live the life you choose.   Connect with Lauren Grace, Lauren Grace Inspirations: Lauren on Social @LaurenGraceInspirations Website: https://laurengraceinspirations.com Join Soul Accelerator: https://laurengraceinspirations.com/soul-accelerator Want to work with Lauren? Book a Free Discovery Call with Lauren: https://laurengraceinspirations.com Free Offers: https://laurengraceinspirations.com/freeoffers   The Afterlight Podcast:  The Afterlight Podcast on Social @theafterlightpodcast To be a guest, apply here: www.theafterlightpodcast.com Sign up for our newsletter: https://laurengraceinspirations.com/contact   Meet Angelica My guest today is Business + Health Coach Angelica Alen. After conquering Stage 3 Bowel Cancer and completing 12 sessions of chemotherapy, feeling stronger than ever, Angelica founded her business to help people achieve optimum health and well-being regardless of their starting point. After successfully building a six-figure health coaching business from scratch, she recognized a common desire among her clients: to help others and create a meaningful impact in the world. This inspiration led her to expand her focus, assisting people in creating life on their terms and sharing their stories to help others heal and evolve as human beings. As a business and health coach, Angelica is dedicated to helping clients build thriving businesses while enhancing their health. Her goal is to guide clients in turning their purpose into a sustainable business that brings happiness and financial freedom. Her unique approach includes NLP to reprogram mindsets for success and habit science, as everything we do is a habit. She also incorporates energetic alignment to ensure energy and intentions align with the life being created. Website: https://www.angelicaalen.com/

ABC journalist Jessica Kidd couldn't believe it, when she was diagnosed with bowel cancer in her early 30s. She's by no means alone. The stats show the number of people under 50 being diagnosed with cancer is increasing. Today, we speak with Jess about her experience and an oncologist about why cancer in young adults is on the rise. Featured: Jessica Kidd, bowel cancer survivorProf Jeanne Tie, medical oncologist and researcher

Bowel cancer is the second-leading cause of cancer deaths worldwide, killing nearly 1 million people per year, and cases of colorectal cancer have been on the rise. But there are glimmers of hope after two studies found that using immunotherapy drugs before surgery dramatically increased the chance of curing bowel cancer in certain patients. John Yang speaks with Dr. Vikram Reddy to learn more. PBS News is supported by - https://www.pbs.org/newshour/about/funders

Bowel cancer is the second-leading cause of cancer deaths worldwide, killing nearly 1 million people per year, and cases of colorectal cancer have been on the rise. But there are glimmers of hope after two studies found that using immunotherapy drugs before surgery dramatically increased the chance of curing bowel cancer in certain patients. John Yang speaks with Dr. Vikram Reddy to learn more. PBS News is supported by - https://www.pbs.org/newshour/about/funders

Cancer, and having a stoma, has changed DJ and broadcaster Adele Roberts' perception of her own body for the better. It's shown her it's ok to cry, and it's ok to ask for help. In this chat with Fearne, Adele talks through the symptoms of bowel cancer, what the experience has taught her about positive mindset, as well as the realities of going through chemo. They also chat about why it's never too late to embrace and practice a new passion later in life, and why it's important not to write off the entire day just because it started a bit crap. Personal Best, Adele's memoir, is out on the 11th of April. Hosted on Acast. See acast.com/privacy for more information.