Podcast appearances and mentions of Matt Wheeler

Curious if your website could save the planet? I'm joined with Matt Wheeler, eco-warrior behind Made by Studio and Green Tech Gathering, who's slashing the web's carbon footprint.In this episode, we're unpacking how to build lean, green websites—ditching bloated code and energy-hogging videos. Matt drops jaw-dropping stats, like a homepage pumping out 360 tons of CO2 a year, and gets real about his autism and ADHD, fuelling his chaotic-creative hustle.What You'll LearnGreen Web Hacks: Trim code and media to cut emissions.Carbon Truths: Why your site's secretly killing the planet.AI's Toll: How data-heavy sites spike emissions.Profit & Planet: Sustainable sites that boost your bottom line.Matt's proof that eco-friendly websites aren't just nice—they're a must, built pixel by relentless pixel.Marketing Vs The World is produced by Urban Podcasts.

Matt Wheeler rejoins me for our final episode on The Horse and His Boy. More episode description to come! Featuring "Wonder of It All" by Matt Wheeler.

If you would like episodes of The Inklings Variety Hour to come out more often, please do consider leaving us a positive review. Singer-songwriter Matt Wheeler once again joins me to discuss his favorite Narnia book, The Horse and His Boy.  Among other things, we talk about: Hermits and the nature of freedom Allegory and biblical allusion in Narnia Fear as motivation Self-pity as incomplete story Matt's song, "Worn Thin" Enjoy, and join us next week for the conclusion of The Horse and His Boy. Feel free to get in touch with me, as always, at inklingsvarietyhour@gmail.com.  Thanks for listening!    

Musician Matt Wheeler joins me to talk about Chapters 7-8 of The Horse and His Boy, specifically Shasta among the tombs (ghouls ahoy), and Aravis' adventures. At the end of the hour, he's kind enough to share an original waltzy song about Aravis, inspired by a COVID toilet paper run. (Seriously, it's a great song--if you listen to nothing else, listen to it.) Before that, we talk about the following: The right way (or lack thereof) to pronounce Shasta and Aravis (and Aslan) Ghouls, ghouls, ghouls Cats and tombs Lewis' characterization of Lasarleen and Aravis The Tisroc (may he live forever) Freedom Calormene view of Narnian history Lapsed Bear! And after the song, Chris throws a little bit of shade at English pronunciation of foreign words to make himself feel better about the fact that he's been mispronouncing Aslan all his life. For more of Matt's music, click here. See you in two weeks, when Matt Wheeler will rejoin us to talk about the journey across the desert!

Physicians are coming down hard on the Government's evidence being used to prop up their changes to bowel cancer funding. Last week, the Government announced it will scrap a programme lowering the screening age for Māori and Pacific people, decreasing the age to 58 for everyone instead. Royal Australasian College of Physicians's Dr Matt Wheeler says the claim that bowel cancer risk is similar across all groups at the same age isn't true. "The actual peak age of diagnosis is earlier in Māori than non-Māori. That was why the original screening programme had bowel screenings down to the age of 50." LISTEN ABOVESee omnystudio.com/listener for privacy information.

Send us a textIn this conversation, Father Matt Wheeler shares his journey from childhood to becoming a priest, highlighting the influence of his family, the impact of literature on his faith, and his experiences in high school and college. He reflects on the importance of faith in his life and how various interests shaped his path. Fr. Matt Wheeler shares his journey from Minnesota to USC, detailing his experiences of homesickness, finding faith, and the call to priesthood. He discusses the importance of community, spiritual direction, and the transformative power of prayer. Fr. Wheeler reflects on his time in seminary and the joy of returning to USC to guide young people in their faith journeys, emphasizing the need for openness to God's will and the hope for the future of the Church.Thanks for Tuning in to Yes Catholic! We're so grateful you joined us for this episode. If this story inspired you, be sure to like, share, and subscribe to keep saying Yes to Jesus with us. Stay connected with the Yes Catholic community on Instagram and subscribe on YouTube @yes.catholic for more powerful testimonies and faith-filled content. Your support helps us continue sharing stories and reaching people all over the world! Thank you in advance for your generosity! Thank you for being part of the Yes Catholic community—where real people share real stories, all for God's glory! Thank You to Our Sponsors! This episode of Yes Catholic is made possible by the generous support of our sponsors Truthly and Tabella. Your partnership helps us continue sharing powerful testimonies and inspiring stories of faith.

It's Season Five of The Inklings Variety Hour, episode one, and you know what that means! Time to return to the enchanting land of-- --record scratch-- --Calormen? That's right, Ed Said. We're kicking off this season the right way, with a little trip to an unprepossessing fisherman's hut and the down-on-his-luck literary ancestor of both a refreshing soft drink and Taran the Assistant Pig-keeper.  I'm only talking 'bout Shasta. Can you dig? You know who else is talking about Shasta? I mean, besides Bree the talking horse (no not that one) who abducts him?  Why, it's Jonathan Geltner, renowned author of Absolute Music, and Joseph Weigel, host of Men with Chests and also an author! Together, we discuss the following subjects: Calormene culture and Narnian culture Literary analogues (or lack thereof) of The Horse and His Boy Formal language and formulaic language The wider world in which Narnia exists Proverbs (Calormene and Narnian) How Tashbaan is awesome Freedom Books we bring up: The Thousand and One Nights Travels in Arabia Deserta David Eddings' Belgariad Series Huck Finn The Prince and the Pauper The Worm Ouroboros The Faerie Queene Copyrighted Music: Original BBC Narnia Theme Mr. Ed theme (not Ed Said) As always, please leave a generous review if you want higher quality or quantity podcasts! This is a labor of love, and I'm currently only able to get something out once every two weeks. See you in two weeks' time, as musician Matt Wheeler joins me to talk (and sing) about his favorite Narnia book.   

In this Q&A episode of ScaleUp Radio, Granger Forson sits down with Sam and Matt, the founders of Made by Studio, to discuss their inspiring journey towards implementing a four-day work week, without compromising on productivity or pay. They share their strategies for enhancing efficiency, building capacity, and managing waste within their business, all while maintaining a strong team culture. Key Takeaways: Data Tracking and Measurement: The importance of tracking and measuring data across all business elements. Sam and Matt emphasise that you can't improve what you don't measure. They started with time tracking on jobs and gradually expanded to include operations and financial management, using automation to gain quick insights into business performance. Capacity Building and Process Improvement: The team at Made by Studio has developed systems that free up time for creative work. By documenting business processes in a resource hub, they reduce knowledge bottlenecks, enabling team autonomy. Additionally, they implemented software like Dext for invoicing and created a proposal template that has dramatically reduced the time spent on administrative tasks. Four-Day Work Week Implementation: Two years ago, Made by Studio transitioned to a four-day work week while maintaining 100% pay for 80% time. They achieve this by setting clear expectations, maintaining regular team check-ins, and fostering a strong, collaborative work culture. Client Management and Scope Creep: The founders share their approach to managing client expectations, which includes setting clear project timelines and using signed proposals to manage scope creep. They frame their client relationships as long-term collaborations, ensuring a shared understanding and future project opportunities. Automation Tools and Techniques: Sam and Matt reveal how they've harnessed tools like make.com to automate many of their business processes. This includes integrating software tools for CRM, invoicing, and financial reporting, significantly reducing the time spent on manual tasks. Make sure you don't miss any future episodes by subscribing to ScaleUp Radio wherever you like to listen to your podcasts. For now, continue listening for the full story from Sam and Matt. Scaling up your business isn't easy, and can be a little daunting. Let ScaleUp Radio make it a little easier for you. With guests who have been where you are now, and can offer their thoughts and advice on several aspects of business. ScaleUp Radio is the business podcast you've been waiting for. If you would like to be a guest on ScaleUp Radio, please click here: https://bizsmarts.co.uk/scaleupradio/kevin   You can get in touch with Kevin & Granger here: kevin@biz-smart.co.uk grangerf@biz-smart.co.uk   Kevin's Latest Book Is Available! Drawing on BizSmart's own research and experiences of working with hundreds of owner-managers, Kevin Brent explores the key reasons why most organisations do not scale and how the challenges change as they reach different milestones on the ScaleUp Journey. He then details a practical step by step guide to successfully navigate between the milestones in the form of ESUS - a proven system for entrepreneurs to scale up. More on the Book HERE - https://www.esusgroup.co.uk/   Sam & Matt can be found here: Matt Wheeler - linkedin.com/in/mattmultiplied https://twitter.com/mattmultiplied   Sam Taylor - linkedin.com/in/samtayl-r https://madeby.studio/ hello@madeby.studio

Māori health leaders are calling on the government to scrap the Treaty Principles Bill, saying equitable healthcare is "a fundamental right". The Royal Australasian College of Physicians' (RACP) Māori Health Committee chair Dr Matt Wheeler said the principles outlined in the bill diminished "the constitutional status of the Treaty / Te Tiriti". "This bill undermines the state's responsibility to collaborate with Māori, rendering the Treaty and its obligations meaningless," he said. "Consequently, equitable healthcare, a fundamental right for Māori, will continue to suffer." ================================== Come support the work we're doing by becoming a Patron of ⁠⁠#BHN⁠⁠ www.patreon.com/BigHairyNews⁠ Merch available at www.BHNShop.nz Like us on Facebook www.facebook.com/BigHairyNews Follow us on Twitter. @patbrittenden @Chewie_NZ

The Royal Australasian College of Physicians' (RACP) Māori Health Committee chair Dr Matt Wheeler said the principles outlined in the bill diminished "the constitutional status of the Treaty / Te Tiriti". Wheeler and other professionals are calling on the government to scrap the Treaty Principles Bill, saying equitable healthcare is "a fundamental right". Poverty isn't a lack of character; it's a lack of cash. "Ideas can and do change the world," says historian Rutger Bregman, sharing his case for a provocative one: guaranteed basic income. Learn more about the idea's 500-year history and a forgotten modern experiment where it actually worked -- and imagine how much energy and talent we would unleash if we got rid of poverty once and for all. Full Ted Talk here https://www.ted.com/talks/rutger_bregman_poverty_isn_t_a_lack_of_character_it_s_a_lack_of_cash/transcript Shane Te Pou, Damien Grant and Bomber thrash it out on the treaty referendum bill, did Māori cede sovereignty and more in a heated debate on TWG last night

As the author of Conviction in the Chaos, Matt Wheeler talks about the chaos that's happening all around us and offers practical ways to cope.

This month, Duane and Scott review metal and heavy rock Christmas songs with special guest, listener Matt Wheeler. Matt's Songs Jingle Bells by Austrian Death Machine Joy to the World (Cover by Minniva feat. Orion's Reign) All I Want For Christmas Is You by Leo Moracchioli Christmas Truce by Sabaton Deck the Joy by Theocracy The Chronicles of Jacob Marley by Order of Nine Duane's Songs Another Rock-n-Roll Christmas by Paul Di'Anno O Holy Night by Floor Jenson We Three Kings by Rob Halford Carol of the Bells (symphonic heavy metal version) by Orion's Reign God Rest Ye Merry Gentlemen by Charlie Parra Del Riego Listener Songs Little Drummer Boy by Marcelo Camela

Recently, a series of papers were published in Nature and Nature journals illuminating the physiologic effects of exercise from an NIH initiative called MoTrPAC. To understand the wealth of new findings, I spoke with Professor Euan Ashley, who, along with Matt Wheeler, heads up the bioinformatics center.Earlier this week, Stanford announced Evan Ashley will be the new Chair of the Department of Medicine. He has done groundbreaking work in human genomics, including rapid whole genome sequencing for critically ill patients and applying the technology for people with unknown diseases. A few years ago he published The Genome Odyssey book. As you'll see from our conversation, he has also done extensive work on the science of exercise.Video snippet from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Transcript with audio and external linksEric Topol (00:06):Well, hello, it's Eric Topol with Ground Truths, and I'm really delighted today to welcome my friend, Euan Ashley. He is the Roger and Joelle Burnell Chair of Genomics and Precision Health at Stanford. He's done pioneering work in genomics, but today we're going to talk about something very different, which he also is working in exercise. Exercise the cover of a Nature paper in May regarding this MoTrPAC, which we're going to talk about this big initiative to understand the benefits of exercise. But before I hand it over to Euan, and I just want to mention his description of the paper that he posted to summarize started with, “Exercise may be the single most potent medical intervention ever known.” So Euan welcome.Euan Ashley (01:01):Yeah, well, great. It's wonderful to be here, Eric, and so nice to see you.Eric Topol (01:06):Yeah. Well, we have a lot to talk about because exercise is a fascinating topic. And I guess maybe we'd start with the MoTrPAC, which is an interesting acronym that you all came up with. Maybe tell us a bit about that with the 800 rats and the 2,400 people and the 17,000 molecules, there's a lot there.Euan Ashley (01:24):Right, right. Yeah. Well, first of all, of course, before you do any scientific study, especially with a large number of people in a consortium, you need a good acronym. So that was where we started with the idea was to focus on the molecular transducers of physical activity. As you pointed out there at the beginning, we really don't have a more potent medical intervention, especially for prevention of disease. I mean, it's just such a powerful thing that we have, and yet we don't really understand how it works. And so, the MoTrPAC Consortium was designed to really work together, bring groups of people across the US together who all have some interest in exercise and some ability to measure molecules and really put together the world's largest study of exercise to try and start answering some of the questions about where the potency of this intervention come from.Eric Topol (02:20):So the first crop of papers, and there were several of them that came out all on the same day in Nature publications, was about the rats. The people part is incubating, but can you give us a skinny on, there was a lot there, but maybe you could just summarize what you thought were the main findings.Key MoTrPAC FindingsEuan Ashley (02:43):Yeah, of course, of course. And the MoTrPAC Consortium, I'll say first of all, yeah, large group is probably I think 36 principal investigators funded by the Common Fund. And so, it brings together large numbers of people, some of whom who spend most of their time thinking about let's say animal exercise. Some have spent a lot of time thinking about humans in exercise and many of whom think about measuring technologies. And as you say, these first group of papers were focused on the rat study, but actually the study goes much more broadly than that. But of course, there are some advantages to the animal protocols. We can look at tissue and we'll talk about that in a moment. But the humans, of course, are where we're most interested in the end. And we do have tissues coming from humans blood and adipose tissue and skeletal muscle, but those are obviously the only organs we can really access.(03:31):So there's a rat study, which is this one we'll talk about, and that's aerobic exercise and training. There's human studies that include aerobic exercise, strengths studies as well. There's a study in kids, pediatric study and then also a study of people who are very fit because here we're focusing on the change from sedentary to fit. And so that gives us the key exercise signal. So this first crop of papers was really our first look, cross-tissue, cross multi-omics, so multiple different modalities of measurement. And I think, yeah, we were like about nine and a half thousand assays, 19 tissues, 25 different measurement platforms, and then four training points for these rats. So let's talk about the rats for a minute. What do they do? So they normally live at night. They're active at night. In this study, we reverse that so that we can actually do the studies during the day.(04:25):So we reverse their at night cycle and they do their treadmill exercise over the course of several weeks. They start with about 20 minutes, and they do more every day. There's a control group of rats that just get placed on the treadmill and then don't do any exercise. And so, this is a controlled study as well. And over the course of time, we work more, it's about eight weeks in total and then two days after each of those bouts of exercise. So it's not an acute study, we measure to see where we are. So we also have this time trajectory of exercise. So what did we find? I mean, I think the first thing I would say, we talked about just how potent exercise is. It's very, very clear from looking at all these tissues that when you exercise regularly, you are just a different person, or in this case a different rat.(05:15):Like literally every tissue is changed dramatically and some in quite surprising ways. So I give you a couple of the things that surprised me or that I thought were most interesting. The first thing was this question of how does exercise actually work? Because exercise is a stress. You go out and you pound the pavement or you're on the bike or whatever, and then your body recovers. And so, there's been this idea, it's referred to as hormesis, this idea that some of the benefit of exercise might come from this recurrent stress. So your body learns how to deal with stress. And so given that we were very interested that this heat shock response was so prominent across multiple tissues. So heat shock proteins are molecular chaperones and they take care of protein folding to make sure it's appropriately done and they prevent protein aggregation. And when proteins need degraded because they're damaged, the heat shock system jumps in.(06:10):So perhaps not surprising, but pretty interesting that the heat shock proteins were very prominent part of the stress response to exercise. And remember, this is not acute exercise, so these are benefits that are built up over time, so that was one. A surprising one to me, the adrenal gland. So we're used to thinking of adrenaline as an epinephrine, as a stress hormone, but actually we saw dramatic changes in the adrenal gland and we don't necessarily think too much. You think about the exercising muscles, you think about the heart, we think about the lungs, when we think about exercise, you don't necessarily think that you're changing your adrenal gland, but it was one of the most changed tissues. The immune system was a common upregulated system. We saw that. And in fact, some of the tissues in which the immune genes were most changed were somewhat surprising.(07:02):So the small intestine, for example, was a place where there was a highest enrichment of immune mediated pathways. And then some tissues changed pretty early, like the small intestine changed after just one or two weeks of training other tissues like the brown adipose tissue. It was more like seven or eight weeks of training before we saw the real changes in there. So just one or two little things that struck out, but I think this really the first molecular map of exercise. So we're looking across the whole system across multiple modalities of measurement across multiple tissues.Simulating StressEric Topol (07:34):So as far as understanding the benefits of exercise, does this tell us that it really does simulate stress that it's conditioning the body to deal with stress as reflected by the various points you just summarized?Euan Ashley (07:51):Yeah, I think that is exactly right. I mean, part of what we were trying to understand was in what way are you changed after you do exercise regularly? And I think if we think about things that are positive, then the ability to deal with stress at a cellular level, quite literally repair mechanisms seems to be a big part of it. The other aspect that was interesting is that when you're measuring this many analytes, you can also compare that with disease. And so, we understand that exercises is preventive benefit against disease. So in some cases, and this was work highlighted by my colleague Maléne Lindholm in the mitochondrial paper that came along with the main paper and she looked with a team across all mitochondrial changes across all of the tissues of the cell. So these are the workhorses of the individual cells that like the batteries inside the cells of the mitochondria.(08:54):And we saw big changes across, it's not surprisingly, but it's the energy source for cells, big changes across many tissues. But interestingly for two specific really important diseases, a liver disease in one case and type 2 diabetes on the other, it was very clear that the training upregulated a network that was exactly the opposite of that of the disease. And so, it really was intervening in a way that was very specifically opposite to the way we know disease mechanisms go. So it does seem like, I mean people talk about an exercise pill. I think this shows that that is just not going to be possible. There may be ways we could mimic some elements of exercise, but there's no pill. This is a multisystem, multi-tissue, multidimensional response to exercise.Eric Topol (09:44):Yeah, I think it's really important. That was one of the questions I was going to ask you is whether this would ever be simulated by a drug. And I think you already answered that, and the fact that it's so comprehensively sweeping across every organ and all these different signals, tens thousand plus signals across them, it's really striking. We never really understood the benefits of exercise and not that it's all resolved by any means. Some of the things that were interesting too was the sex specific findings. Maybe you want to comment about that because we don't spend enough time thinking about how sex does have a big effect on physiology.Sex-Specific FindingsEuan Ashley (10:24):Yeah, I mean that's a really good point and one that I think was really underlined for us at every corner, every turn of the analysis here. So really no matter which measurement modality, no matter which tissue, no matter which point of training, if we just asked these computer models to sort of separate the data according to the prominent signals without giving it a clue of what to do, the so-called unsupervised models, then sex basically came out every single time. So I think you say you're absolutely right that we so often overlook the difference. For years we've said, oh, it's too expensive to do animal studies in both sexes, so we'll just pick one. And males were picked more often. But there are plenty of studies that were just females, and I mean that clearly is wrong, and we are really, sometimes it appeared like we're almost dealing with two different species.(11:18):They were so different. But I think we can also learn from what those differences were. Interestingly, some of them were most profound in adipose tissue, so in fat, and that was the case both at rest, sedentary and amplified by exercise. So we saw big difference between females and males in relation to the kinds of signals that were prominent in the white adipose tissue. So this fat storage tissue, for example, in sedentary females, insulin signaling and the trigger to make fat and store fat was very prominent. But whereas in the males, even before any exercise, the fat signals were more related to metabolism, and we could have wild speculation about in evolutionary terms why that might be. Obviously, males and females have different biological many differences in their biology and obviously thinking about hormone systems and specifically pregnancy of course. And so, we could probably come up with some theories. In reality, all we know now are these observations were found and they're pretty interesting and they show us that we really always need to think separately about both sexes and look at both independently.Eric Topol (12:39):Well, and the other thing that you already pointed out, but I just want to underscore, you can't do this stuff in people. You can't just do fat biopsies and whatnot. So I mean, the fact that you can do this multi-omic, multi-organ type assessment is just really an extraordinary opportunity for learning. And while we're on the white fat story just briefly, we would rather have a lot more brown fat, but as we age, and I assume it's the same in rats, they don't have much as they get older brown fat. Does exercise help us get more brown fat or are we just stuck with the white adipose tissue?Brown vs White FatEuan Ashley (13:21):Yeah, well, it certainly allows us to have less of a white adipose tissue, and I think it's potential that our brown adipose tissue maybe more functional, and for those who are listening who are not familiar, I mean these really are different colors that relate to the actual color of the tissue, but the color is different because the brown adipose tissue contains lots of mitochondria and lipid droplets, and the brown adipose is there to help essentially generate heat. It has a very different function in a way, but even white adipose tissue that we think of as just being about storing energy, people think of fat as a very metabolically neutral or inert tissue, but in reality it's not. It's signaling. It's constantly, it's a tissue that's as alive as any other and not just a storage for excess energy, but exercise definitely appears to alter both in this sexually dimorphic way as we noted already and clearly both in a positive health way where I think the makeup of the brown tissue is different. The white tissue, there is less of it obviously with exercise, which is something that is well known, but not new here for the first time. But still important to have seen that even in the rats.Eric Topol (14:49):And there's even, we talked a moment go about drugs, but there are some molecules that are thought to be able to help convert white to brown fat that are understudy and we'll see if they get anywhere that's interesting. But also, you talked about aerobic exercise and with us both being cardiologists, and I know throughout my earlier part of my career, we only talked about aerobic exercise. There was no such thing as strength training, and we even discouraged that or we never talked about it. Now we know how important strength training is and not just strength and resistance training, but balance and posture and all these other things. I assume you can't study that in the rats.Euan Ashley (15:32):Well, it's not impossible. This study of course is about endurance, but as you say, and there are some models, I mean I've even seen models in trying to trigger flies to do strength training.Eric Topol (15:46):Wow, I didn't know that.Intensity of ExerciseEuan Ashley (15:46):That somewhere, yeah, we'll have something, there are various methods of making animals hang off things, and this was treadmill. So it's a fairly routine and standard I think part of a rat's life to run. So this was not so different. As we mentioned at the beginning in the human study, we do have a strength portion and the endurance portion, which I think is very important because as you say, the benefits of exercise are found really across both of those. And indeed, as you say, flexibility and other often neglected element of physical activity. But yeah, those benefits are there for both aerobic exercise and endurance. And in fact, they are perhaps even higher for higher intensity exercise. Although I think we don't necessarily recommend everybody do higher intensity exercise. I don't think it's necessary to get most of the benefits of exercise, but there is some additional benefit.(16:42):One of my favorite facts, I think I first saw it probably on a presentation a few years ago, but I looked up the original and recalculated it. But if you look at this very big study of half a million people and look at their physical activity over the course of years and correlate it with their likelihood of being alive or being dead, then it was clear that one minute of exercise bought you five minutes of extra life. And I just thought that was just a really interesting way of putting it essentially. And actually it's a little more, if you did high intensity exercise, one minute would give you seven or eight minutes of extra life. So I tell this to my patients when they come in and tell me they don't have enough time to exercise. I said, oh, well, one minute of exercise. I'm not very popular when I tell them that, but anyway.Eric Topol (17:30):You think it's true. Do you think it's based on good data?Euan Ashley (17:34):Well, the data is large, I mean half a million people. I think we've also seen it currently since the early fifties when we were first doing the London bus conductor study that Jerry Morris did that you will know well, where he compared bus conductors on the London to the bus drivers and found a significantly reduced cardiovascular mortality among the conductors because they were on their feet all day up and down stairs and the driver otherwise in the same environment the drivers were sitting. So I think we have a wealth of epidemiologic correlative evidence that exercise leads to a greater length of life, greater longevity, maybe more than for anything else. The causal evidence is less of course, but we do have causal evidence too. There are enough randomized trials and now increasingly some genetic causal evidence that helps us understand that this is really a causal link and that we actually can change our outcome if we do additional exercise.Mental Health BenefitEric Topol (18:32):Oh, and I don't question at all what you said about the enhancing healthy aging health span and even possibly lifespan. I just wondered about the one to five ratio if we could assert that. I mean that's really interesting and it's a good motivating factor because as you well know by that WHO criteria, one out of four people aren't even close to the modest exercise recommendation. So we got ways to go to get people to spruce up exercise. Now speaking of people, I do want to come back to MoTrPAC and the people plan, but I do want to before that get your sense about a couple of really fascinating studies. So earlier this year there was a study of every exercise study that's been looking at mental health along with SSRIs that name drugs that are used for mental health. And it was a pretty fascinating study. I think I'm just going to pull it up. They looked at everything that this is for depression, walking, jogging, yoga, strength training, SSRIs. And what was fascinating is that dancing, walking, jogging, it made the drugs look like a joke. They didn't seem to work at all. So this was 218 studies with over 14,000 people. And so, I don't know that enough people recognize this fact that this Prozac nation and all this stuff about the SSRIs, but exercise seems to do wonders for people who are depressed, anxious, stressed. What do you think about that?Euan Ashley (20:26):Yeah, I mean it's exactly right. I mean I think that it's very clear from the data and as you mentioned, you and I tend to focus first on the cardiovascular benefit, which is very significant, potentially 50% reduction in risk, but there are similar sorts of numbers when you look at mental health and exercise as an intervention for mental health has been very well studied and has these really dramatic benefits. And I think even if we go in the more general population and think about the fact people talk about a runner's high or an exercise high, and many, many of us, myself included, feel that. And a few years ago, I started exercising every morning and now if I don't do that, I really feel like I'm missing something, there's something in the chemistry of my brain is not quite right. And so, I think that benefit for those who have mental health issues is also very much felt and is real at the brain chemical signaling level and with this few adverse effects as exercise has, I do think we need to think of it earlier and more prominently for almost every disease.Eric Topol (21:40):Yeah, you're I think alluding to the opioids that are released with exercise and addiction to exercise, which is what ideally if everybody could be addicted to exercise, that might help a lot of things. As you mentioned in your post that I started with, “its benefits in prevention outstrip any known drugs: 50% reduction in the cardiovascular disease, 50% reduction in risk of many cancers, positive effects on mental health that we just discussed, pulmonary health, GI health, bone health, muscle function. You name it.” So you said it really well there, and that was just one recent report that substantiated the mental health. I want to also mention another report that's fascinating on cancer that is a publication again recently was looking at both mice and people with pancreatic cancer. And what was fascinating about it is the more exercise of the mice and in the people, the more survival that is from pancreatic cancer, which as we both know and all the listeners will know, is that one of the worst cancers of humankind. So the affecting cancer is fascinating. Now can you dial up your immune system response with exercise?Euan Ashley (23:02):Yeah, I think you can. And I think we were at some level expecting to see it because it's certainly a known thing, but I think again, this is able, our ability to measure it in this study is just much deeper than we've ever had in any study before. And so, I think when we think about mechanisms that might relate to reduced risk of cancer, as you say, we think first of the immune system and that signal was there in many places. As we mentioned at the very beginning, sometimes to me in some slightly surprising places like the small intestine, we don't think of that necessarily as the seat of immune activation, but I think what we were doing, what we were seeing is those signals really across all the tissues and ultimately the immune system is a distributed system. It senses in multiple places and then obviously has implementation.(23:53):Now exactly in what way we've turned up our T or B cells, for example, to be able to attack those cancers or support the therapy that's been given. I don't think we understand that yet. But actually, you bring up another great point, which is part of MoTrPAC was to create this molecular map and analyze it and put the first analysis out there. So that's what we've done, but just as big and maybe even a bigger reason is that to release the data and to make it accessible for everyone and anyone in the world as of the moment this paper came out can go to our data portal at https://motrpac-data.org/ and download the data and then use that in their own work. They can do their own analysis just of this data, but also what we're hoping is that they'll start to use the data, let's say as control data for a cancer study or for a diabetes study or for others. So we really hope it'll fuel many, many more studies over many years from now.Eric Topol (24:52):Yeah, I mean that open science approach to applaud that it's so vital and amplifies what's good to come out of this really important initiative. Now you mentioned the opioids and proteins that are secreted with exercise, exerkines is a term that's used and also I guess these extracellular vesicles (EVs) not electric vehicles. Can you tell us about exerkines and EVs and are they part of the story?Euan Ashley (25:25):Yeah, and actually in the human study there's a specific exosome analysis that will be reported there. Yeah, I think that when we think about this multi-system nature of exercise, and one of the fascinating things was to be able to have these omics in multiple tissues and think about how those tissues were signaling to each other. So obviously there are some tissues that are more fundamental to the exercise response. We think of those as the skeletal muscles. They literally the effectors of our ability to exercise. And I think we think of the heart and lungs in particular in the blood system of course, but we were seeing changes everywhere and it's one of the reasons we were seeing changes everywhere is that there are molecules that are essentially secreted into the circulation or locally by these exercising muscles, exerkines that have a number of positive benefits.(26:21):And it is possible if there's some mechanism towards mimicking some of what exercise does with a drug, then that's a good place to go look for it. And I think that this will also fuel those thoughts. I think we both, we'd agree that there isn't going to be one pill that will do all the magic of exercise, but I think there are probably things we will learn from the study where we say, well, this was a very positive benefit and it seems to be mediated by this particular molecule, and that's something that could potentially lead towards a more targeted drug. I think we'll definitely get into that and understanding just we're systems people are, again, I think we think in physiology, so when we see the tissues like connecting and communicating with each other, I think that just makes a lot of sense from a systems perspective.Eric Topol (27:10):Now getting onto the forthcoming work that's going to come out with the 2,400 people and the different groups that you mentioned, I wonder if it'll include things like biologic aging with DNA methylation, will it have immunomes to characterize the differences in the immune system? What kind of things might we expect? Obviously, you can't get tissue, but for blood samples and things like DNA methylation, can we get some more illumination on what's going on?Euan Ashley (27:41):Yeah, I think we can. And of course, ultimately the human is the organism we're most interested in. Interestingly, I'll say interestingly as well, we can get some tissue and huge credit to both the investigators who are doing this and most credit of all to the individuals who agreed to join the study because they actually agreed not just to give blood samples, but actually to give skeletal muscle samples. So a biopsy of the skeletal muscle and a biopsy of the fat pad. So we will actually have two other tissues in the humans, not this obviously vast range that we talked about with the rat study, but we'll have those two other tissues and we'll also then have the rat data, which is the other great thing. So we'll have this foundational insight that we can then bring to the human study with the humans as we mentioned before as well, we'll have not just endurance but strength trained, we'll have it in kids as well, and we'll have these higher intensity exercise.(28:36):I think we will be able to connect with this, as you mentioned, longevity literature or the health span literature where we can start to think about DNA methylation. We do have genomes of course, on all of the individuals. It won't be a study powered because it's thousands individuals, these kinds of numbers. It won't be powered to give us genetic predictors. If you think about the studies had to be hundreds of thousands of people and even more now in order to give us, let's say common variant predictive. So we won't be able to do that, but there's lots of connections we'll be able to make by being much closer to the effector systems, which is to say the proteins and the metabolites and those signals we're already seeing are very significant. And so, I do think that there'll be a lot of new signals that we'll see that are specific to humans that will connect into other bodies of work, for example, the longevity, and we'll see those in blood and I hope that we'll be able to connect also the skeletal and adipose tissue data as well.Eric Topol (29:37):One of the things that would be wonderful to connect if you can, our mutual friend and your colleague at Stanford, Tony Wyss-Coray has these organ clocks that have been validated now in the UK Biobank, and then you can see what's happening with the wealth of plasma proteins that have been validated across each organ. So without having to do tissue, you might get some real insights about organ clock. So I mean, I'm really looking forward to the people part of this. When do you think the next wave of output's going to come from MoTrPAC?Euan Ashley (30:11):Well, I think that another element of the study is that we have ancillary studies, so investigators who said, I want to be able to use MoTrPAC data and use some of the infrastructure, but I'm looking for funding for my parallel study. So some of those ancillary studies will start to come out over time, which I think will be interesting and will be a very good place to see the breadth of activity that has been triggered by this one investment. The human study is coming along. We're actually just now plotting the last two or three years of the consortium. Time has really gone by pretty fast, and we've had to scale back just a little bit on the total numbers of humans, but it should still be, I think probably the largest multi-omics study of humans that there has been. And I think if we were going to plan one of those, then planning it to study around exercise definitely, definitely makes sense. So there is some data that was, of course Covid happened in the middle of this, so that was a major challenge with hitting the original numbers. But there's some data from the humans who were recruited before Covid hit that will be coming out and hopefully in the relatively near future. And then the big study may still be a year or two away to get it finished. But after that, as we say, we hope that the data and the science will continue for I hope decades beyond just the collection of this repository.Eric Topol (31:41):That's great. You mentioned Covid and I did want to ask you about the folks with Long Covid who are suffering from fatigue and exercise intolerance and what do you think about this kind of vicious cycle? Because if they could exercise, it could help them get into a better state, but because of not being able to, it's just a negative feedback loop. Any thoughts about that?Exercise and the Immune SystemEuan Ashley (32:13):I mean, it's such a good point and it's one of course that we talk to many of our patients where they, for whatever reason, sometimes it's because they are struggling with weight or they're struggling with other mobility challenges, and now we have this very large population who are struggling with fatigue. As you mentioned, it's a group that we were somewhat familiar with because of flu and because EBV and other, I mean long syndromes were something we were familiar with. They were just kind of rare, and so there wasn't really much work done on trying to understand them. Now as you've, I think articulated better than anyone, we have this entire population of people because of the scale of Covid who have these symptoms that are recognizable for the first time and including on your podcast, you have had folks on that have discussed it. Some of the insights that have happened from actually applying science, I wish there was an answer that was buried here in MoTrPAC and maybe there is, there will certainly have data from before and after the pandemic and maybe there may be some insights that we can bring to that.(33:20):I certainly think we have a lot of insights on the interaction between infection and the immune system. We talked about the potential for the immune system to be ramped up in that potentially being one of the mechanisms through which this might help cancer. There's also the idea of, and we've seen this with the effect of vaccination on Long Covid, which perhaps surprisingly does seem to have a significant benefit for at least a group of people. The assumption there is that we're ramping up the immune system and it's having that extra effect on whether it's actually pools of hidden antigens that are hidden from the immune system or whether it's some other element of the kind of ensemble attack of the immune system that is related to the symptoms. But either way, I think we feel that having a more ramped up immune system is likely to be beneficial, but at a very real human level, the point you made is the hard one. If you're really fatigued and you just feel you can't exercise, then these benefits are just out of reach and you're in this negative feedback cycle and breaking that cycle is hard. I think we try to suggest people do it very gradually because you can get a lot of benefit from just a little exercise and that's something, so that's some way, and then hopefully people can build up slowly over time, but it's a really big challenge.Eric Topol (34:43):I hope we can crack the case on that because I know that's something holding these folks back and there's just millions of them out there. Now let's talk about the healthy folks that you see in clinic. What do you advise them about exercise besides the fact that one minute we'll give them five minutes, but do you advise them to have X amount of aerobic and X amount of resistance and in the general person, what would you tell them patients?Euan Ashley (35:13):Yeah, yeah, I do. So I suggest habit is everything. So I suggest to people that they exercise every day or take one day of rest because I think there is some benefit with the stress response and having a rest day. So I suggest five or six days a week if possible, trying to get into a habit of doing it. So pick a time that works for you. It could be first thing in the morning, could be last thing at night. The jury's out on when the best time to exercise is. What it's very, very clear is that getting the exercise done is what counts. Accumulating time is also what counts. I mean, if you're not someone who wants to pull on running kit and go out running, that's fine, but accumulating steps, accumulating physical activity and moving is key. So not having people overshoot being too ambitious, but if they're really motivated to do something, then I would say five or six times a week a combination of both aerobic and endurance exercise and strength.(36:07):Usually I suggest two to one in favor of aerobic exercise, but it's also possible I think to alternate and do more 50/50. I think the key is that both are featured and then I think a bit neglected because to be honest, our data on it is just not as good, but flexibility is really critical and particularly in the senior population and for a group who sit all day long, I think for those two groups in particular, flexibility is really under-recognized as a major component. Even in my cardiology clinic, I've helped several patients just get over their back pain by teaching them some back stretching exercises. And so, I think that's neglected. So I suggest all three of those and really it's whatever works for the individual. I think the key is to find, it might be working in a group format, it might be going to a gym, it might just be taking regular walks. The key is to get moving and not sit. Get moving and do it regularly and get into the habit.Individualized Exercise?Eric Topol (37:09):Yeah, and actually on that point about potential individualization in the future, I noticed that you and some people that worked in your lab and others, Svexa is a company you started for exercise. Can you tell us about that?Euan Ashley (37:26):Yeah, this was a PhD student who was in my lab many years ago and was doing his PhD joint between the Karolinska Institute in Sweden. And of course, the country of Sweden has a long history of exercise physiology, science, and as he came out, we realized that there was the potential for optimization of training for individuals, whether they're recreational athletes or elite athletes in the Olympics. And he was interested in taking this and running with it, which he did. So the company originally Silicon Valley exercise analytics, but shortened now to Svexa builds, builds products to help people basically individualize their training. And we work, say with recreational athletes on an individual basis, we work with a lot of Olympic athletes in multiple countries and the technology building the sort of magic sauce that many of these coaches even up to and including Olympic coaches have into a format that can be spread and amplified to many more people is one of the themes.(38:29):And when we think about professional athletes and the company works with a number of well-known brand name teams that are in soccer leagues and in national football league here in the US and really across professional sport, what we're thinking of there is optimizing performance. Of course, all the teams want to win, but reducing injury is the other key part because the management of load, these are professional athletes, they're getting up every day in training and they're trying to optimize their training and their coaches are trying to do that. And it's been a fairly data free zone over the years, but meanwhile, we actually have learned a lot about how to measure individuals and how to measure what training works, and if you think about a team that might be paying 20 million a year for their star player, if that player gets injured, that's a pretty expensive thing. And so, investing a little bit in understanding the training load, helping the coaches understand the data, and then adapting that to each individual in the team so that their chance of injury is lower. That's really a lot of what the company spends its time thinking about.Eric Topol (39:36):Now, do you use sensors like lactate and glucose and AI of their body and how do you figure this stuff out?Euan Ashley (39:45):Yeah, all of that is possible. It's interesting, some sports have a kind of culture of measurement. For example, lactate measurements, which as your listeners will know, is it requires a small blood sample usually from the finger or from the ear lobe. Some sports like swimming have done that for years. But other sports, it's just not been so much in the culture. So I would say that from the company perspective, we work with whatever data is available and we'll make recommendations if people want to think about wearable devices. Of course, the digital era is around us, and you can get a lot from just a standard watch in terms of heart rate, heart rate variability in terms of accelerometry and movement. You can do a lot with just that, but there's lots more. Many of these teams have GPS signals so they know how far an athlete moves in a given game, how fast they move, how much time they spend at tool speed versus medium speed.(40:37):So we can use all of that. And as you say, yes, AI for sure is a large part of what we do and a couple of different ways actually. One is just for the analysis of the data, but another is this idea of scaling expertise. This is something in the AI community. I know you talked about a lot where you could take the expertise of let's say a physician with a very specialized practice or an Olympic coach for a marathon runner and basically make a language model that contains that expertise and then allow many people, thousands of people potentially to benefit from that expertise that we'd otherwise be sort of locked up with next available appointment is 18 months down the road, but if your AI can potentially reflect a lot of what you have, a lot of your expertise, not all of it, we hope, but probably a lot of it, then that expertise could potentially be offered much more broadly. And if it's to help people exercise more and more effectively, it's going to be a lot of good that I think can come from that.Eric Topol (41:33):Yeah. No, it's really interesting. I think there's unlimited opportunities there. It's like Moneyball to the 10th power. It's like all this data that's in sports that gets me, I guess to the last question I had for you, and that is the elite athlete or athlete hard. These are people that are working out endurance just to the max, these extremists, and they're prone to heart issues like atrial fibrillation. Why is that? What's going on with these people that they exercise too much? Is it just the lack of moderation, extremism or what's going on?Euan Ashley (42:10):Yeah, well, so it's interesting that of course you mentioned atrial fibrillation. I think that really is the only downside of exercise, even fairly extreme exercise that I've ever been, I think that we've ever had really good data for. And I would say that over the years, and I've been one way or another touching the exercise science world for 20 years and more now and certainly have been asked very often, surely these people are doing themselves harm. And the reality is, although every now and again there's a study that shows some harm or they measure troponin, they measure something in the blood and someone says, oh, they must be doing themselves harm. It's been very hard to find it. The reality is atrial fibrillation though really is, especially for those ultra endurance athletes, that's for real. And that is, we don't know that it's associated with a mortality impact necessarily, but it's definitely annoying and it slows down.Endurance Athletes and Atrial Fibrillation(43:03):We have athletes who come in and say they're cycling up a hill and suddenly they drop their power drops and they realize they've gone into atrial fibrillation. I used to play basketball with someone who would go into atrial fibrillation, so I would know when to try and get past him once he went into atrial fibrillation. But that's a real thing, and I think one of your questions was why I think I have a lot of close friends who are ultra endurance runners. They're among some of the most chilled and happiest people I know. I think those benefits of exercise are what they're enjoying, and I think there's a literature on addiction to exercise. So there is a small number of people who get addicted to that feeling and addicted to the chemical matter in their brain and can't stop, and they really do get to the point of doing themselves harm.(43:53):Fortunately, I think that's a pretty small number. And overall, although there are many consequences of chronic long-term exercise, almost all of them seem to be positive. The other one that you and I are probably very familiar with is the calcium scans that we see now much more often, it's common for people who've exercised a lot to have more calcium in their hearts. Now they have a lower risk of that. They have lower risk of heart attacks in general, one or two studies muddied the waters just a little. But in general, it's very clear they have very positive health benefits and yet they have more calcium. So they are an exception. We've seen in our sports cardiology clinic here at Stanford, several athletes every month, several will come in with this finding and we are explaining to them, this doesn't mean they have the same risk as someone who hasn't exercised at that level who would have that calcium score. It does seem to be very different, and it may be that there's a stabilization of those plaques in the arteries. I don't think we understand the biology that well, but we understand the epidemiology quite well, which is that their risk really is still low.Eric Topol (44:59):Yeah, no, it's interesting that there's still some uncertainties there and MoTrPAC may help guide us or at elucidate some of them. I guess it does bring up one other thing I got to get to with you because we didn't really get to the question of moderate to higher intensity, not to the level of the ultra exercises, but if you just do steps or do you sweat like hell, where do you draw the line? Or is that really part a function of age and ability? When you recommend exercise, because obviously you're rational and there's others out there that are exercising three or four hours a day and they're going to extreme craziness, but just in a reasonable thing, do you think just telling people who are 70 that walking is good enough or do you try to encourage them to push it?Euan Ashley (45:59):Yeah, I do encourage people to push it a bit because I think there's clear evidence that higher intensity, some degree of higher intensity exercise really does provide more benefit. But I think my main message first is because for most people, the potential of moderate versus high is in the distance and in the future for most people, we need to get them off the couch and get them on their feet. So my emphasis is that you can go a long way with just a little movement, even a little standing. And then I think if they're really getting into the habit and really doing some exercise then, and if they don't have a prior history of let's say, heart attack or other medical issues that might make high intensity exercise risky, if they don't have those, then I absolutely do get to the point where I recommend some amount of higher intensity exercise, because I think there is some evidence that it has a little extra benefit.Eric Topol (46:51):Oh, that's great. Well, this is the most in-depth conversation I've ever had with anybody on exercise, so Euan I really appreciate it. I mean, I knew you from all your work in genomics of course, and we've had some overlap from time to time, but the exercise stuff is fantastic. Did I miss anything?Euan Ashley (47:09):No, I don't think so. Just underline again to anyone who's listening if they're interested to play with this data, it's very much out there. It's a tool for the world, and they can go to https://motrpac-data.org/ and even you can do some analysis without downloading any data either. If you just have a favorite gene or a favorite protein, you can type that in and take a look at some of the tools we have there. But yeah, really appreciate the conversation and very fun to chat about what has been a really, really fun project.Eric Topol (47:39):Well, thank you and all the folks at MoTrPAC, all the hard work and of course the funding that got it going to give it that runway of several years. So we'll look forward to more. I hope to convene with you again when some of the other studies come out, and thanks so much.*****************************************************Thanks for listening, reading or watching!The Ground Truths newsletters and podcasts are all free, open-access, without ads.Please share this post/podcast with your friends and network if you found it informativeVoluntary paid subscriptions all go to support Scripps Research. Many thanks for that—they greatly helped fund our summer internship programs for 2023 and 2024.Thanks to my producer Jessica Nguyen and Sinjun Balabanoff for audio and video support at Scripps Research.Note: you can select preferences to receive emails about newsletters, podcasts, or all I don't want to bother you with an email for content that you're not interested in. Get full access to Ground Truths at erictopol.substack.com/subscribe

We're back, and it's a great day to have songwriter, poet and troubadour Matt Wheeler on the show! This acoustic/folk musician is known for his reflections on art, faith and classic literature. He chats to Jess about his latest release, 'A Hard History of Love' inspired by the works of Wendell Berry, and gets real about how storytelling gives us a way to process pain. Connect @MattWheelerVH and https://MattWheelerOnline.com Buy/stream 'A Hard History of Love' here: https://linktr.ee/mattwheelervh MUSIC A Hard History of Love by Matt Wheeler The Ballad of Tol & Minnnie by Matt Wheeler 1934 by Matt Wheeler Your Vintage Heart by Matt Wheeler Ready for the Storm (Cover) - The Black & White series by Matt Wheeler Aravis by Matt Wheeler Coming Back Again ft. Citizen Way by Jamie Jamgochian ADVERTISMENTS Connect with the 'Songs That Changed You' podcast here: https://apple.co/48pWMMA SUBSCRIBE/CONNECT/LET'S BE FRIENDS: https://linktr.ee/betweenyoumepod Music published with permission of artist and fair use permissions. Produced by Josh Dunn Media.

Matt Wheeler, The Irish Heritage Trust's General Manager at Johnstown Castle Estate, Museum & Garden ahead of the unveiling of a stain glass window from World War One which has been restored.

-- There may be an unexpected fix for ongoing shortages of insulin: A brown bovine in Brazil recently made history as the first transgenic cow able to produce human insulin in her milk. "Mother Nature designed the mammary gland as a factory to make protein really, really efficiently," explained study leader Matt Wheeler, a professor of animal sciences at the University of Illinois Urbana-Champaign. "We can take advantage of that system to produce a protein that can help hundreds of millions of people worldwide." --- Send in a voice message: https://podcasters.spotify.com/pod/show/arthur-harris0/message

Pennsylvania-based singer-songwriter Matt Wheeler joins us as our guest co-host and he gets to pick out all the music.--- TRACK LIST FOR EP.99 ---1934 - Matt WheelerKeeper - Jonathan OgdenIs There Room Enough For Me - Zane VickeryWearing Love - Joy IkeOrchestrated Love Song - Burlap To CashmereGrateful - Morgan Harper NicholsTotal Praise - Richard Smallwood and VisionMy Transfiguration - Jon GuerraBrand New Day - Ellie HolcombCalling Out Your Name - Rich MullinsWhat A Savior (Psalm 65) - Melanie Waldman ft. WaterdeepA Hard History of Love - Matt Wheeler--- CREDITS ---Host/Producer - Dave TroutAlbum 'A Hard History of Love' - https://is.gd/mwahholspMatt's website - https://mattwheeleronline.comSPONSOR1: Dustin Starks - https://is.gd/dswhenspSPONSOR2: Andrew Greer - https://sc.lnk.to/JBoHp5SPONSOR3: Wild Bison Festival - https://is.gd/wildbison24UTR Contest for Charlie Peacock set - https://utrmedia.org/wincpsetBook Review for Charlie Peacock & Andi Ashworth - https://utrmedia.org/cpbookreviewEmail: gourmetmusicpodcast@gmail.comAll Songs used with permission or under fair use provisions(c) 2024 UTR Media. All Rights Reserved. A 501(c)(3) non-profit org - info at https://utrmedia.org

Matt Wheeler, professor of Animal Science at the University of Illinois shares his recent study, creating the first insulin- producing cow.

Super excited to announce new guest, Matt Wheeler, to The Story!Matt Wheeler is a Lancaster County, PA-based troubadour, poet with a guitar, & stage banter-conversationalist. Matt's songwriting paints pictures with words, often drawing inspiration from classic works of literature or simply spinning new original stories in song.Check out Matt and his projects here:Website: http://www.mattwheeleronline.com/Find The Story Podcast here: coryrosenproductions.com/podcastsSupport this podcast at — https://redcircle.com/the-story/donations

Sponsored by TrackableMed In a world of artificial intelligence and virtual reality, why does MedTech remain 5 years behind other industries when it comes to modern solutions? Part of the problem is accessibility. Sales reps are constantly traveling cross-country to meet with surgeons they may never hear from again. But what if there was a way to meet with more surgeons without wasting so many resources?  Matt Wheeler is a visionary entrepreneur, highly skilled business associate, and proven sales leader with over 20 years of experience. As the Chief Revenue Officer at Immertec, he plays a pivotal role in driving revenue growth and guiding the organization toward success. In this episode, sponsored by TrackableMed, Matt sits down with us to talk about how Immertec's virtual reality headset can bring 100 people to the same operating room. We discuss the value behind saving time and resources, the advantage of increased accessibility for practicing physicians, and how this distant learning experience actually leads to more in-person success. Join us for more about: Improving the learning experience by taking surgeons out of the operating room instead of the other way around Increasing conversion rates with early-stage education Accelerating the number of people you can get into your early-stage funnel How this technology can benefit sales, marketing, R&D in addition to surgeons Resources from this episode:  Get the free MedTech Talk Tracks for Action Immertec Social Media:  Connect with Matt on LinkedIn Connect with Zed on LinkedIn Connect with Clark on LinkedIn

This time on ScaleUp Radio, I had the pleasure of interviewing co founders, Matt and Sam who founded Made By Studios, a digital marketing agency. They are a couple of really great guys and it was really good to see the dynamic between them and hear how that dynamic changed over the time they have know and worked together.  They've been running the business for about four years. They met at university on the same course did a project together before going into business together. And there's quite a few things that they've learned along the way and things that they would do differently if faced with again.  I'd love you to listen to the conversation around niching.  They have recently decided to niche into a couple of particular sectors and the reasons why they've done that are really interesting.  But also they had a significant project early on that turned out to be really rather difficult and it put a big strain on their relationship, which led them to a couple of things. One was putting in place a proper shareholder agreement and another was really thinking about each other's mental health and then of course the rest of their team.  So they put a couple of neat little things in place. Nice simple ideas that really help keep on top of each other's mental health. And they found that that really made a difference to the energy and creativity that they have, and generally the work life balance and culture within the business.  So some really good things within this interview and I thoroughly recommend that you take a listen   Matt & Sam can be found here: Matt Wheeler - linkedin.com/in/mattmultiplied https://twitter.com/mattmultiplied   Sam Taylor - linkedin.com/in/samtayl-r https://madeby.studio/ hello@madeby.studio   Resources: Off Script by Josh Nesbitt - https://podcasts.apple.com/gb/podcast/off-script/id1490897256 Agencynomics by Peter Toole - https://www.waterstones.com/book/agencynomics/peter-hoole/jazz-thompson/9781999327170 Radical Candor by Kim Scott - https://uk.bookshop.org/p/books/radical-candor-fully-revised-and-updated-edition-how-to-get-what-you-want-by-saying-what-you-mean-kim-scott/3226418?ean=9781529038347 LinkedIn - https://www.linkedin.com/   Scaling up your business isn't easy, and can be a little daunting. Let ScaleUp Radio make it a little easier for you. With guests who have been where you are now, and can offer their thoughts and advice on several aspects of business. ScaleUp Radio is the business podcast you've been waiting for.   If you would like to be a guest on ScaleUp Radio, please click here: https://bizsmarts.co.uk/scaleupradio/apply   You can get in touch with Kevin here: kevin@biz-smart.co.uk   Kevin's Latest Book Is Available!    Drawing on BizSmart's own research and experiences of working with hundreds of owner-managers, Kevin Brentexplores the key reasons why most organisations do not scale and how the challenges change as they reach different milestones on the ScaleUp Journey. He then details a practical step by step guide to successfully navigate between the milestones in the form of ESUS - a proven system for entrepreneurs to scale up.    More on the Book HERE - https://www.esusgroup.co.uk/

Patients and sites that recruit and enroll patients change how trials are executed. Year after year, R&D costs incurred by biopharmaceutical companies to bring new therapies to the market are skyrocketing.There is also a lack of appropriate racial representation among study participants. As clinical trial sponsors fail to reach their recruitment targets, these dynamics have led to a greater reliance on clinical trial partnerships for execution.With this said, in this episode we'll clarify how sites and patients are changing the way trials are executed and how the necessary changes bring growth to the market.We're super excited to bring in Matt Wheeler and Ian Tzeng, both Managing Directors in L.E.K. Consulting's Boston Office, to share their thoughts. They will be today's speakers.Connect with our experts on LinkedIn:Matt Wheeler: https://www.linkedin.com/in/wheelermatthew/Ian Tzeng: https://www.linkedin.com/in/iantzeng/ Visit L.E.K. Consulting at https://www.lek.com/

In this episode I spoke with Matt Wheeler, Executive Director with the California Building Officials (CALBO). In this episode we discussed his role as executive director, how he works sot engage code professionals and the private sector across California, resources CALBO provides code professionals, efforts to recruit new members into the profession, and many more topics. To find more information about CALBO, please visit their website at https://www.calbo.org/.

It turns out that no matter how much you go to school, you still might end up in sales. Matt Wheeler is an accomplished CPA and firm manager who learned the hard way that there is more to winning business than just getting the meeting. Who I am: Matt Wheeler is the managing partner of Wheeler Accountants and a tax advisor for serial entrepreneurs, individuals with complex equity compensation and general partners of Venture Capital and Private Equity funds. His goal and focus is to minimize the taxes my clients pay over their entire lifetimes. He lives in San Jose with his wife and four(!) children. Find me here:https://www.linkedin.com/in/mowcpa/

Our guest today is one Matt Wheeler. The terms "troubadour", "poet with a guitar", & "stage banter-conversationalist" all describe Matt Wheeler's music & performance style well. Matt's songwriting paints pictures with words. Matt has delighted audiences from New England to North Carolina, Ontario to Chicago. His new album "Wonder of it All" - a collection of songs based on classic works of literature like "The Little Prince" & "The Hobbit", was released on 5/21/21.For our conversation today, we are going to be discussing Ongiara “ahn-gee-AR-uh”, with a hard “g - the third studio album by Canadian folk rock band Great Lake Swimmers, released on March 27, 2007. The album was released on Nettwerk and the band recorded most of the album in London, Ontario's historic music venue Aeolian Hall with producer Andy Magoffin.For those wondering, Ongiara is the name of a boat that ferried the band to the site where they recorded the first demo. It's also the original indigenous name of Niagara Falls. Enjoy and thanks for listening!

Another blast from the Pandemic Past! Actor/producer Matt Wheeler (Key and Peele, Punk'd) is still on his hair losing journey and hilariously shares about his insecurities and mishaps in covering up, including a cringeworthy Giuliani hair drip moment on a first date. Matt also talks about his blind faith dive into acting coming after from rural Kentucky, his insane past as a fundraiser for high schools selling chocolate, insecurities and the drunkest he and Charlie have ever been thanks to a German bartender at a Chinese themed bar. Learn more about your ad-choices at https://www.iheartpodcastnetwork.com

What are the best ways to land meetings with high quality prospects? How do we drive the behaviors needed to compete in today's busy world?Matt Wheeler lives these questions every day, and helps his clients land those elusive meetings. What can we learn from his process, and the success qualifiedMEETINGS has with it's clients? And how can these processes help you achieve your goals in-house. Listen and learn from one of the best in the business! NEW Research Report Sales Development Benchmarks. Grab full report here: https://tenbound.mykajabi.com/research_report The Tenbound Sales Development Conference, come learn from the best in our industry. Prospecting. Plays. Pipeline. Free virtual conference this year June and August! https://tenbound.com/conference/ Book Launch: The Sales Development Framework: by David Dulany and Kyle Vamvouris lay out a proven methodology for running a high performance Sales Development program, now available here in paperback Grab it here. https://www.amazon.com/Sales-Development-Framework-Productive-Program/dp/1736768905/ #SDR #BDR #salesdevelopment #tenbound #podcast #sales #marketing #salesengagement #salesenablement #research #prospecting

In this episode of the "Recruiting Roundtable", Jeff and Paul talk with Matt Wheeler, Co-Founder and Co-CEO of SportsRecruits, a college recruiting platform empowering student-athletes to pursue their dreams. SportsRecruits is a platform we use with our Pro Skills athletes, and it's been a huge benefit over the last two years so this episode is a great chance to hear more about it. Matt Wheeler co-founded SportsRecruits in 2008, and has been a driving force behind the company's success. As Co-CEO, Matt oversees all aspects of Technology Development and Customer Support. Matt takes great pride in leveraging his experience to provide real value to athletes and their families. The "Recruiting Roundtable" with Jeff Vangorder and Paul O'Connor covers all things college basketball recruiting from advice for high school players to interviews with college coaches & other experts to Q&As and much more! Jeff is our PSB Philadelphia Director and Paul is our PSB Columbus Director and both have a ton of college basketball experience. Jeff has been a DIII coach for the last number of years with his current position being an assistant at Ursinus while Paul coached at DI's Central Connecticut State and Kennesaw State before moving over to the grassroots side of hoops. __________ The Youth Hoops Pod covers topics such as: High school & AAU basketball College basketball recruiting NCAA basketball NBA & professional overseas basketball Mental health & performance Leadership Basketball coaching And much more! __________

In this episode, Fr. Matt Wheeler reflects on how Catholics serve and build the Catholic Church by focusing on the family. "

Madison Holden, 3-wide at the finish line winner at Lavonia Speedway; Matt Wheeler, the “voice” at Lancaster Motor Speedway, and Sye Lynch, sprint car racer from western PA are this week’s guests.

Randy talks with Matt Wheeler, Managing Partner of Wheeler Accountants and co-host of the Avocado Toast podcast, about his unique approach to promoting financial literacy. Through his podcast and other initiatives, Matt advocates for education, since people don't know just how much financial support and advice they need. The more they learn, the more likely they are to seek out professional accounting and financial services. Get the full show notes and more resources at TheUniqueCPA.com

Fellow SPEED SPORT Podcast Network host from In The Garage with Jeremy Taylor joins Kyle for some bench racing! Plus, we got an interesting perspective from an announcer/crew chief. Matt Wheeler and Brandon Conard, crew chief for Chris Ferguson Motorsports, to preview this upcoming weekends big super late model races Learn more about your ad choices. Visit podcastchoices.com/adchoices

We get to know two fantastic singer-songwriters on the show - Treva Blomquist & Matt Wheeler. ----------- TRACK LIST FOR EP.32 ----------- "Strong" - Treva Blomquist "Shape I'm In" - Treva Blomquist "Safer" - Matt Wheeler & Vintage Heart "Harbor" - Matt Wheeler & Vintage Heart ------------ CREDITS ----------- * Host/Producer - Dave Trout * Treva Blomquist's Website - http://trevamusic.com * Matt Wheeler's Website - http://mattwheeleronline.com * Treva's latest album - https://is.gd/trevasp * Matt's latest album - https://is.gd/mwvhsp * SPONSOR1: Weston Skaggs - https://is.gd/wssunsp * SPONSOR2: Amazon Smile (and select "UTR Media" to support) - https://smile.amazon.com * SongRx Email Signup - https://is.gd/utremail (c) 2020 UTR Media. All Rights Reserved. A 501(c)(3) organization - info at https://utrmedia.org * Special Thanks: The Rabbit Room

Life can be hard on us at times and pastors aren't exempt from bad days either. On today's episode Brandon and Jordan talk with Pastor Matt Wheeler of Oak Hills Church in Edmond, Oklahoma, about leading your family through challenges. Pastor Matt gives us a look into the life of a pastor, especially focusing what it's like to pastor while trying to lead his family well. He shares his struggles and heart breaks while also giving sound advice on seeking help from God and a counselor. He shows us as men that it is okay to seek a counseling relationship and be vulnerable and transparent. We are all human and make mistakes, or just need someone to help us make better plans and goals for our lives. Pastor Matt explains how dominating at work, but not thriving at home is, in the end, failing. We need to give our bests as dads, employees, or even pastors. Our families are our next most important relationship after God. It is vital to get poured into and not feel like you are only pouring out to others. Matt shares how starting his day in God's word is key in having a good day and making sure he is centered on what matters the most. -- If you would like to check out Pastor Matt Wheeler's church online, or in person, visit Oak Hills Church: https://www.ohcedmond.com/ --- Support this podcast: https://anchor.fm/2dads1mind/support

Matt Wheeler is singer/songwriter who also fronts his band Matt Wheeler & Vintage Heart. Matt also educates everyone in facebook land as a daily fact giver. You can find those on facebook with a search of #RandomFactsWithMatt.You can find more about his music at http://www.mattwheeleronline.com

Matt Wheeler is the last troubadour is world gone electric.  Originating from Lancaster Pennsylvania, he's developed a natural style of songwriting which stretches from his incredible consumption of literature.    Matt is a educator, a husband and valiant man of the people.   Today we discuss how he draws audiences in with engaging stories and interactions.  Alone Matt is witty, clever and smart , when joined by his band Vintage Heart, the poignant lyricist become the lead vocalist of an incredible collection of musicians who have been friends since collage.   Together they create orchestral folk songs that touches your soul a little more with each listens.  http://www.mattwheeleronline.com/ --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

I interview Matt Wheeler, manager and founder of South London Panthers FC in the Metropolitan Sunday League Podcast Sponsors Down to Play, Sports King TV, Home Food Plug, Abal Pest Control, Baldon Sports Youth & Clare Barnett Graphic Design Charity XI Sponsors: TW Drainage, ReQuest & Dave Cumberbatch Photography #selk #footballfamily #wegoagain #staystrong

In this episode, I talk with Matt about how he got started playing music, how things have changed performing live, and how he defines success as a musician. Listen on: Apple Podcasts/iTunes | Spotify | Google Podcasts Matt Wheeler Links: Website Facebook Twitter Instagram

Jonathan Germany and Matt Wheeler discuss how true Joy can give us strength.

This week's episode is different from our traditional format. We have a special guest, and one of my best friends, Matt Wheeler, LPC During Matt's growing up years,  he was afraid to let others know that my family was in therapy, as there was often negative stigma and stereotypes attached to it. Gratefully getting help from a mental health professional today is more widely accepted. Matt strongly believes that we are not meant to be alone in this life. Sadly, many of us suffer difficulties that leave us feeling isolated and on our own. As a therapist, Matt quickly gravitated to attachment work and he loves to help individuals, couples, and families learn to connect and attach securely to each other. I have extensive training and practice in emotionally focused therapy (EFT) which is the “gold standard” for this attachment work.  Matt is also a certified sex addiction therapist (CSAT) and at Family Strategies Counseling Center.  He has been a practicing mental health clinician since 2012. In this episode, Matt discusses the hierarchy of connection and gives the listener tools and tips to help make a deeper connection. To learn more about the Finding Peace Retreat go to https://www.findingpeaceacademy.com/finding-peace-retreat   You can listen to other episodes in the Finding Peace podcast here: https://podcasts.apple.com/us/podcast/id1472700242 https://open.spotify.com/show/0p6DK6fPPjHH0z911oCuUg https://www.troyllove.com/thefindingpeacepodcast   #Connection #connections #friendship #friendshipismagic 

5/19/18 In the opening hour of the show, Brad Porter talks about the Royals 5-3 victory over the Yankees and the solid performance of the bullpen and Whit Merrifield, and the possible trade chips on the Royals as currently constructed. Brad is then joined by Matt Wheeler of ESPN to talk all things NBA draft and how the top picks may unfold, as well as where the locals might end upSee omnystudio.com/listener for privacy information.

4-22-18 In the opening hour of the show, Brad Porter begins by talking about Sean Menea throwing a no-hitter for the Oakland A's and where the Royals would be if they would have kept hi,. Brad also is joined by Matt Wheeler of ESPN to talk all thing NBA Draft and where the locals could land and evens talks about the exciting NBA playoffsSee omnystudio.com/listener for privacy information.

4-7-18 In the opening hour of the show, Brad Porter, Jed Marshall and Charlie Karlan discuss the latest in sports including Connor McGregor losing his mind in New York and getting arrested and the amazing start of Shohei Otani in MLB. Brad also brings in Matt Wheeler of ESPN to discuss the local prospects chances in the NBA Draft.See omnystudio.com/listener for privacy information.

In the second hour of the show, Brad Porter brings in former Royals pitcher Al Fitzmorris to talk Royals baseball and Fanfest, Matt Wheeler from ESPN to talk about the NBA Draft status of the local schools.See omnystudio.com/listener for privacy information.

Today we have Matt Wheeler (@mattwheeler), Co-Founder of the tech startup SportsRecruits, the tech startup behind the recruiting management software platform by the same name. This episode is all about breaking down the recruiting process. Here's why this episode is so valuable: while Matt has close to 15 years of experience with recruiting, this talk isn't just about drawing from his experience. Rather, he combines the intuition he's gained from all that experience with real, hard, empirical data to tell you what you need to know, and he cuts out all the other BS and misinformation you'll find elsewhere.  He talks about the statistical realities of playing in college at the all levels, how many schools high school athletes should target to give themselves the best shot at overcoming the pretty steep odds; he breaks the recruiting process into three pillars: research, proactive outreach, and exposure. Most importantly, he gives you the blueprint to getting recruited. It requires a lot of effort, but it's he maps it out for you in a way you're not going to find elsewhere. Of course, the devil is in the details, so rather than me taking more time with this summary, here's Matt Wheeler.

We dig under the hood of a growing technology business called Sports Recruits LLC founded by Chris Meade and Matt Wheeler in 2008. We discuss their struggles in keeping the business going early on and what got them to profitability. Chris Meade and Matt Wheeler are co-founders of Sports Recruits LLC, which operates LacrosseRecruits.com, VolleyballRecruits.com, FieldHockeyRecruits.com… The post SA 003: Chris Meade and Matt Wheeler, Co-Founders of Sports Recruits LLC, on the StartUp Life appeared first on Nick Dinardo.

On today's episode we talk to Matt Wheeler and Chris Meade, co-founders of LacrosseRecruits.com about the recruiting process for high school level players.