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So, let's talk about HKU5—a coronavirus variant that's just one mutation away from potentially infecting humans. Should we be worried? Could this be the next pandemic threat? Tune in to this episode to find out! We've seen how fast viruses can spread once they make the jump to humans, and with scientists discovering HKU5, this topic has sparked significant concern in the scientific community and even spooked the financial markets—causing unnecessary panic, financial market fluctuations, and public uncertainty. But should we really be alarmed? Or is this another case of fear outpacing the facts? In this episode, we'll answer all that as we discuss everything you need to know about HKU5. From its potential to mutate, why experts are concerned, to whether or not it could trigger another pandemic—we'll cover all that in today's podcast. So, if you want to know whether or not this could be the next global health crisis, tune in to this episode as we separate fear from reality and prepare without the panic. Why you need to check this episode: Learn about the characteristics of the HKU5 virus and how it compares to other coronaviruses like MERS-CoV; Discover why HKU5 has the scientists' attention and why financial markets have reacted to this news; Understand the role of mutations in virus transmission and know whether this strain poses a real threat to humans; and Differentiate scientific caution from media-driven panic, and learn what we can do to stay prepared and informed of HKU5's risks. “So, there are some things we know and some things we don't know about this HKU5 variant. What I can tell you right now [is] no, we're not headed to a new pandemic, [and] yes, I do think it was an overreaction, especially from these financial markets to sell off and almost mini-crash just because they hear of a new coronavirus—a very big overreaction [that] did not need to occur, especially when you're inclined to actually read the data…So again, should you be worried? No, but definitely be prepared for any news to come.” – Dr. Berry Pierre Notable Quotes: “This hasn't happened yet, [but] theoretically, from a lab perspective…these mutations are possible that can now make this HKU5 variant that primarily affects bats, cattle, and sheep to now jump to human cells…It has not happened yet, but there is a concern there.” – Dr. Berry Pierre “No one wants to be caught off-guard to a new variant, to a new virus—because we saw what happened when we were caught off-guard with the first one.” – Dr. Berry Pierre “We're still dealing with the coronavirus now, we're still dealing with variants now, [and] people are still dying now, even though you're not seeing it on your TV. It's off the TV—they made sure of that…So, you're not going to get the necessary fanfare…but trust me, we're still seeing these patients in the hospital [and] people are still dying in the hospital from it.”– Dr. Berry Pierre “As we continue to move in this post-pandemic world, understand that we can do some things better than what we did the first go around. We can educate better. We can learn better. We can try to break down any misconceptions better. We can do a lot of things better, especially for those who are fortunate enough to still be alive after the pandemic.” – Dr. Berry Pierre Sign up at www.listentodrberry.com to join the mailing list. Remember to subscribe to the podcast and share the episode with a friend or family member. Listen on Apple Podcast, Google Play, Stitcher, Soundcloud, iHeartRadio, and Spotify Resources: The Article that Dr. Berry Read Watch Our Previous Episodes Discussing the Coronavirus Below: Answering YouTube's Pressing Covid-19 Questions Why Covid-19 and the Flu are NOT the Same Thing Are COVID Cases Rising Again What is Long COVID Doctor Reacts to Monkeypox Vs Covid-19 Debate Doctor Reacts to Covid-19, Omicron Variant, & School Shutdowns What is the Covid-19 Omicron BA.5 variant 4 Million Cases Later with COVID-19 (coronavirus update)
In his weekly clinical update, Dr. Griffin reviews the recent statistics on SARS-CoV-2 infection, before discussing methods for sterilizing filtering facepieces, an update to the fall COVID boosters, the emergency use application of a pre-exposure prophylactic and where to find it and drug interaction database, convalescent plasma, the effectiveness of the monoclonal antibody sotrovimab against Omicron variants, what to do when healthcare workers succumb to SARS-CoV-2 infection, the need for better nursing resources, how survivors of COVID-19-associated ARDS exhibited sustained elevation in endothelial dysfunction biomarkers, correlating with the severity of impaired gas exchange, reactivation of latent CMV as a consequence of a SARS-CoV-2 infection, identification of variables that might impact or predict a person's time to recovery from an acute SARS-CoV-2 infection and if COVID-19 patients really have olfactory dysfunction more often than normally smelling individuals. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 national trend (CDC) COVID-19 deaths (CDC) Comparison of methods for sterilizing filtering facepiece respirators (American Journal of Infection Control) Booster update already! KP.2 of JN.1-lineage (FDA) EUA for pemgarda (FDA) Where to get pemgarda (Pemgarda) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) Revisiting monoclonal antibody therapy, sotrovimab for treatment during Omicron BA.2 and BA.5 (Infection) What do when your healthcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Hospital nurse staffing variation & COVID-19 (International Journal of Nursing Studies) Endothelial dysfunction and persistent inflammation severe post-COVID-19 (BMC Medicine) Prevalence and risk for CMV reaction due to COVID-19 pneumonia (PLoS One) Variables that impact recovery from acute SARS-CoV-2 infetion (JAMA Network Open) Reduced olfactory bulb volume with dysfunction after mild SARS-CoV-2 inction (Scientific Reports) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1124 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
hVIVO Chief Executive Officer Mo Khan joined Steve Darling from Proactive to share significant news about the company's latest developments. hVIVO has signed a £2.5 million contract with a mid-sized pharmaceutical company to initiate an Omicron characterisation study. The manufacturing of hVIVO's Omicron BA.5 challenge agent was successfully completed in 2023. Khan explained that the study aims to identify a dose of hVIVO's Omicron BA.5 challenge agent that can establish a safe, measurable, and reproducible disease in healthy volunteers aged 18-30. The goal is to achieve sufficiently high infection rates to use this model for testing the efficacy of antivirals and vaccines in the future. The study is expected to commence in Q4 2024, with the majority of revenue recognized in 2025. It will be conducted at the company's new CL3 quarantine facility at Canary Wharf. This state-of-the-art facility has been specifically designed to meet the highest hospital isolation suite standards suitable for CL3 pathogens. It is equipped with advanced safety features, including physical containment barriers, controlled ventilation systems with negative pressure and HEPA filtration, and comprehensive waste management protocols. This will be the first COVID-related human challenge study that hVIVO will undertake since the contract announcement in June 2022. The study represents a significant step forward in understanding and combating the Omicron variant of the virus, contributing valuable data for the development of effective treatments and vaccines. Khan highlighted the importance of this contract for hVIVO, emphasizing the company's leading role in the field of human challenge studies. The successful completion of this study will not only advance scientific knowledge but also reinforce hVIVO's reputation as a pioneer in the development of innovative solutions for infectious diseases. In conclusion, hVIVO's £2.5 million contract for the Omicron characterisation study marks a pivotal moment for the company. With its advanced CL3 quarantine facility and proven expertise in human challenge studies, hVIVO is well-positioned to make significant contributions to the fight against COVID-19 and other infectious diseases. The study's findings are expected to play a crucial role in the development of new antivirals and vaccines, ultimately helping to safeguard public health #proactiveinvestors #hvivoplc #aim #hvo #clinicaltrial #antiviralcandidate #humanchallengestudy #biotechnology #rhinovirus #medicalresearch #humantesting #viralload #pharmaceuticals #medicalstudies #clinicalasset #clinicalcontact #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews
Rosinbomb (OTC:ROSN) proudly announces a significant patent filing, showcasing the unique and proprietary air circulation system of the Nature Fresh Freeze Dryer. This innovation includes a revolutionary Piezo electric fan system seamlessly integrated into their innovative honeycomb rack system, optimizing airflow and enabling customers to process nearly twice the amount of material in the same time. Global biotechnology leader CSL (ASX:CSL; USOTC:CSLLY) and Arcturus Therapeutics (Nasdaq: ARCT) announced the results of a follow-up analysis of a Phase 3 study evaluating a booster dose of ARCT-154. The new analysis at 6 months post-vaccination shows that ARCT-154 induces a longer immune response as compared to Comirnaty for both the original Wuhan strain and Omicron BA.4/5 variant. For more information, please visit StockDayMedia.com
Viện Y tế và Phúc lợi Úc AIHW vừa công bố một phúc trình toàn diện, tiết lộ tổng số tiền Úc đã chi cho hệ thống y tế, để ứng phó với dịch bệnh COVID-19, từ năm 2019-20 đến 2021-22. Điều này xảy ra khi Úc phải đối mặt với COVID vào mùa Giáng sinh, do biến thể phụ Omicron BA.2.75 còn được gọi là Centaurus.
On episode #41 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 10/26 - 11/08/23. Host: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS Become a patron of Puscast! Links for this episode Intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant in Hong Kong (JID) Efficacy and safety of corticosteroid therapy for community-acquired pneumonia (CID) Hydrocortisone in severe community-acquired pneumonia (NEJM) Early oral antibiotic switch in Staphylococcus aureus bacteraemia (CID) Outbreak of invasive Group A Streptococcus in children (PIDS) Inhaled amikacin to prevent ventilator-associated pneumonia (NEJM) Assessing risk for complications in acute hematogenous osteomyelitis in children (JPIDS) Empirical antibiotic therapy in diabetic foot ulcer infection increases hospitalization(OFID) 2023 guideline on diagnosis and management of acute bacterial arthritis in pediatrics (JPIDS) Natural history of antibiotic-treated lower limb cellulitis (OFID) Missed opportunities for preventing congenital syphilis (CDC) Diverse clinical manifestations and challenges of mucormycosis (OFID) Malaria (The Lancet) Clinical characteristics and outcomes of Chagas disease (AJTMH) Direct gloving vs hand hygiene before donning gloves in adherence to hospital infection control practices (JAMA) How I approach diarrhea in hematological transplant patients (TID) Innovating pediatric infectious diseases recruitment and training (JPIDS) Music is by Ronald Jenkees
Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Alvea's Story, Wins, and Challenges [Unofficial], published by kyle fish on November 1, 2023 on The Effective Altruism Forum. Intro A few months ago, the other (former) Alvea executives and I made the difficult decision to wind Alvea down and return our remaining funding to investors. In this post, I'll share an overview of Alvea's story and highlight a few of our wins and challenges from my perspective as an Alvea Co-Founder and former CTO, in hopes that our experiences might be useful to others who are working on (or considering) ambitious projects to solve the biggest problems in the world. I'm sharing everything below in a personal capacity and as a window into my current thinking - this is not the definitive or official word on Alvea and it doesn't necessarily represent the views of any other Alvea team members. I expect my reflections to continue evolving as I further process the journey and outcomes of this project, and hope to share more along the way. Alvea's Story First vaccine sprint and decision to continue Alvea (December 2021 through April 2022) We launched Alvea in response to the Omicron wave of COVID-19 (the most transmissible and immune-evasive variant then to have arisen) as a short-term, high-risk project with the goal of developing an easily-deployable, room temperature-stable DNA vaccine against Omicron as quickly as humanly possible, without compromising on safety and quality. We ultimately carried this vaccine candidate into Phase I clinical trials in less than 6 months, becoming the fastest startup ever to take a new drug candidate from company launch to a human clinical trial. Our success in this initial sprint caused us to expand our ambitions for Alvea and explore ways of building on the track record and momentum we'd built up. One of our initial strategies was to deploy our first vaccine (which was optimized for the Omicron BA.2 variant), and then leverage our development platform to roll out updated versions in response to the emergence of new variants. However, a few key updates convinced us that this was not a promising path. First, the time between waves of new variants continued to drop, making it more difficult to keep up with viral evolution. Second, the FDA and other regulators began an expedited approval process for updated versions of the mRNA vaccines that had already been authorized, making it more difficult for new vaccines to break into the commercial market (a great pandemic regulatory move, though!). Additionally, early efficacy results for our vaccine were underwhelming and suggested that it was unlikely to provide sufficient protection to justify continued investment, particularly against the newest variants in low- and middle-income countries. In light of these updates we decided to stop development of our candidate and consider other paths forward. Product pursuits (May 2022 through July 2022) Despite discontinuing our first vaccine program, we believed we'd landed on a compelling model for general-purpose acceleration of promising drugs and vaccines into the clinic, so we set out to find other high-impact products we could accelerate with this approach. We specifically targeted products and technologies with early published preclinical data that were nearing readiness for clinical testing, with the idea that we could pick them up and dramatically speed up their development and deployment. We ran multiple "product pursuits" in parallel to explore possible technologies, with particular focus on nucleic acid vaccines that could be formulated as dry powders for inhaled administration and on therapeutic interfering particles, a class of RNA therapeutics/prophylactics that are expected to be highly resistant to viral evolution. Neither of these efforts uncovered product opportunities that were clearly good bets under this m...
Episode 149: COVID Vaccines UpdateFuture Dr. Williams presented an update on COVID-19 vaccines. This update is only for immunocompetent individuals, and it was recorded on August 24, 2023. Dr. Arreaza added comments and insight. Written by John Williams, MS4, Ross University School of Medicine. Editing by Hector Arreaza, M.D. You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Currently, there are two types of vaccines that have been approved by the FDA:Moderna and Pfizer developed mRNA vaccines.Novavax developed a lesser-known protein subunit vaccine.As of May 6, 2023, the vaccine developed by Johnson & Johnson has expired and is not available in the U.S.Novavax: This vaccine contains pieces (proteins) of the virus that causes COVID-19, the spike protein plus an adjuvant. It works by activating the immune system against the spike protein, so it will be ready to fight the actual virus when you get infected. Regardless of vaccine type, the shots are administered in the upper arm and have been demonstrated, for most people, to be safe and effective. There have now been hundreds of million vaccines administered in the US alone and the effectiveness of the vaccine to reduce the risks of severe illness, hospitalization, and death has been well documented. The most common side effects consist of mild to moderate cases of fever, chills, headache, and tiredness that are self-resolving.What is new about COVID-19 Vaccines?The updated vaccine is known as “bivalent”. This term is important because it refers to the vaccine's ability to confer protection against both the original COVID-19 virus as well as new variants Omicron BA.4 and BA.5. Rollout of the updated vaccine began in September 2022 for those aged 12 years and older and became widespread in March 2023 with approval granted for use in children aged 6 months – 4 years. Selected individuals over age 65 or those who are immunocompromised may receive additional doses to provide comparable and safe protection. The receipt of the updated vaccine supersedes any previous doses and provides coverage against the most recent known variants determined to be either most widespread or that have been projected to be more prevalent.Children aged 6 months – 4 years who received the original Pfizer vaccineThose who received either 2 or 3 doses of the original vaccine should receive 1 dose of the updated vaccine.Those who received 1 dose of the original vaccine should receive 2 doses of the updated vaccine.You are considered up to date if you have received 3 vaccine doses, including at least 1 updated dose.Children aged 5 years who received the original Pfizer vaccineThose who received 1+ doses of the original vaccine should receive 1 dose of the updated vaccine.You are considered up to date if you have received at least 1 updated dose.Children aged 6 months – 4 years who received the original Moderna vaccineThose who received either 2 or 1 dose(s) of the original vaccine should get 1 updated vaccine.Children aged 5 years who received the original Moderna vaccineThose who received either 2 or 1 dose(s) of the original vaccine should get 1 updated vaccine.Unvaccinated children 6 m-4 years should receive the new bivalent vaccine, 2 doses ofModerna or 3 doses of Pfizer, but if you are 5 years old and unvaccinated, you will receive 1 dose of Pfizer or 2 doses of Moderna.For 6-11 yo patients who have been vaccinated with 1 or more doses of monovalent (Moderna or Pfizer) will receive 1 dose of Bivalent Moderna or Pfizer. If you already received 2 monovalent doses and 1 bivalent dose, you are done, no more vaccines are needed. If you have not received any COVID-19 vaccine and you are in this age group (6-11 yo), you only need 1 bivalent dose, and you are done.>12 yo and Adults. If you received 1 or more doses of monovalent or if you are not vaccinated, you need 1 dose of bivalent (Pfizer or Moderna). If you already had 2 doses of monovalent and 1 dose of bivalent, you are done!An FDA advisory committee convened on June 15, 2023, to discern the importance for additional updates to the most recent COVID-19 vaccine series. It was determined that the latest circulating variant currently making rounds is from the Omicron group known as XBB. The committee decided it is prudent to proceed with a preference for the XBB 1.5 variant. The updated vaccine will be a monovalent version available in the Fall of 2023. As with the previous version, the FDA will provide strict oversight and safety monitoring of the vaccine._______________________________Conclusion: Now we conclude episode number 149, “COVID Vaccines Updates.” Future Dr. Williams explained that the bivalent COVID vaccines are currently recommended for unvaccinated patients, or for those who were previously vaccinated with monovalent vaccines. This episode focused on patients who are NOT immunocompromised. We encourage our audience to check the CDC website for recommendations about patients who are immunocompromised.As a clarification, our sub-intern, John Williams, has a great sense of humor and he claimed to be the composer of the music for many famous Hollywood movies. We don't doubt his musical talent, but we must make clear that it was a joke! This week we thank Hector Arreaza and John Williams. Audio editing by Adrianne Silva.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Tin, Alexander, New COVID vaccine and booster shots for this fall to be available by end of September, CBS Texas, published online on August 9, 2023. https://www.cbsnews.com/texas/news/covid-vaccine-booster-xbb-variants-september-2023/, accessed on September 7/, 2023.Center for Disease Control and Prevention, Overview of COVID-19 Vaccines, updated May 23, 2023, https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/overview-COVID-19-vaccines.html, accessed on September 7, 2023.Updated COVID-19 Vaccines for Use in the United States Beginning in Fall 2023, United States Food and Drug Administration. https://www.fda.gov/vaccines-blood-biologics/updated-covid-19-vaccines-use-united-states-beginning-fall-2023, accessed on September 7, 2023.Royalty-free music used for this episode: Gushito - Latin Chill. Downloaded on July 29, 2023, from https://www.videvo.net/
In his weekly clinical update, Dr. Griffin discusses guidance on measles during the summer travel season, the Infectious Diseases Society of America guidelines on the diagnosis of COVID-19: antigen testing, SARS-CoV-2 variants and age-dependent infection rates among household and nonhousehold contacts, effect of COVID-19 vaccination on household transmission of SARS-COV-2 in the Omicron era, incidence of myopericarditis after mRNA COVID-19 vaccination, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant in Hong Kong, safety, immunogenicity and protection of heterologous boost with an aerosolized Ad5-nCoV after two-dose inactivated COVID-19 vaccines in adults, awake prone positioning for non-intubated patients with COVID-19-related acute hypoxic respiratory failure, melatonin effects on sleep quality of COVID-19 patients, female reproductive health impacts of Long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders, and incident autoimmune diseases in association with SARS-CoV-2 infection. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Guidance on measles during the summer travel season (CDC) Infectious Diseases Society of America guidelines on the diagnosis of COVID-19 (CID) SARS-CoV-2 variants and infection rates among household and nonhousehold contacts (CDC) Effect of COVID-19 vaccination on household transmission of SARS-CoV-2 in the Omicron era (IJID) Incidence of myopericarditis after mRNA COVID-19 vaccination (Science Direct) Intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant (JID) Safety, immunogenicity and protection of heterologous boost with Ad5-nCoV after two-dose inactivated COVID-19 vaccines (The Lancet) Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxic respiratory failure (BMC) Melatonin effects on sleep quality of COVID-19 patients (BMJ) Female reproductive health impacts of Long COVID and associated illnesses (FRS) Incident autoimmune diseases in association with SARS-CoV-2 infection (CR) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1020 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update Dr. Griffin discusses FDA authorizing the first over-the-counter at-home test to detect both influenza and COVID-19, monoclonal antibody for the prevention of respiratory syncytial virus infection in infants and children, epidemiologic characteristics of SARS-CoV-2 recombinant variant XBB.1.5, COVID-19 vaccines vs pediatric hospitalization, maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children, fatal fulminant cerebral edema in six children with SARS-CoV-2 Omicron BA.2 infection in Taiwan, certifying deaths due to COVID-19, efficacy of first dose of COVID-19 vaccine vs no vaccination on symptoms of patients with long COVID, and the effect of COVID-19 vaccination on long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA authorizes over-the-counter at-home test to detect both Influenza and COVID-19 (FDA) Monoclonal antibody for the prevention of RSV in infants and children (JAMA) Epidemiologic characteristics of SARS-CoV-2 variant XBB.1.5 (CDC) COVID-19 vaccines vs pediatric hospitalization (Cell) Maternal SARS-CoV-2 vaccination and infant protection during the first six months of life (Nature) Immunoglobulin, glucocorticoid, or combination therapy for MIS in children (The Lancet) Fatal Fulminant Cerebral Edema in children with SARS-CoV-2 Omicron BA.2 infection (JPID) Certifying deaths due to COVID-19 (CDC) Efficacy of first dose of COVID-19 vaccine vs no vaccination on patients with Long COVID (BMJ) Effect of COVID-19 vaccination on long COVID (BMJ) Contribute to our ASTMH fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 988 Don't crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
幾個關於變種病毒的速報。 美國最新一週XBB.1.5佔比有修正，還有台灣，日本針對中國入境驗到的病毒株初步都是BA.5.2還有BF.7為主。 1.美國新的一週病毒定序有修正。過去三周XBB.1.5 校正回歸為11.5-->18.3-->27.6%，增加占比的速度沒有上週直接衝到40%看起來這麼嚇人。BQ家族還是占最多 55.8%，BF.7，BA.5都繼續減少。但東北新英格蘭區域以紐約為主的確XBB.1.5已經成主流，也開始看到長輩的住院人數開始增多，值得繼續追蹤。 2.台灣指揮中心昨天公布，自1月1日至1月4日針對中國入境採檢，共採檢3999件，825名陽性，陽性率為20.6%。入境陽性率約莫在17.6%至25%之間挪移，每日陽性率會隨著入境地區感染情況不同而有所異動，這4天觀察陽性率約20%左右。1月1日自中國來台陽性個案有100多件，指揮中心針對Ct值26以下的10多件進行定序，目前以BA.5.2、BF.7為主，另外有少數BA.5.1，都是已知且常見的病毒株，不過目前尚未完全完成定序，詳細數據待累計更多資料後再公布。 3.日本從12月30日開始中國入境日本做落地快篩，七天檢查了4895人，其中陽性是408人，約8%。半數以上是無症狀。厚勞省目前公布了主要是12月30日入境的病毒監測，來自中國的64人中，全部都是Omicron。BA.5.2佔28例，BF.7佔32例。沒有驗到XBB或XBB.1.5。 04b解讀： 1.台灣和韓國針對中國入境的PCR陽性率大概是20~30%之間。台灣前幾天採檢657人時新聞有寫其中陽性164人，陽性率為25%，其中Ct值小於或等於30者計有42人，就是其中大概只有四分之一是病毒量比較高的。其他四分之三可能多半是幾個月內感染過的陰陽人。當然也有機會是正好抓到病毒量正在上升的人就是了。但我們大概在現階段是不太需要大費周章去釐清這件事了。 2.對比日本這個數字是落地快篩病毒量較高的才會抓出，落在8%，是很合理的數字。 3.如果後續資料大概就和中國自己公布的差不多，都以BA.5.2、BF.7為主，沒有看到令人擔心的新朋友，累積資料量再大一些後，我想應該就可以比較安心一點了。反而美國這邊XBB.1.5的動向更值得關注。 歡迎追蹤前台大感染科醫師。04b的發聲管道！ 我的電子名片 https://lit.link/linshibi 希望大家當我的種子教師，推廣正確的新冠衛教。科學防疫，不要只以恐懼防疫！ 歡迎贊助林氏璧孔醫師喝咖啡，讓我可以在這個紛亂的時代，繼續分享知識努力做正確新冠相關衛教。 https://pay.firstory.me/user/linshibi Powered by Firstory Hosting
In his weekly clinical update Dr. Griffin discusses the infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave, virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans, time to negative PCR conversion among high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated by Sotrovimab or Nirmatrelvir, COVID drug Paxlovid was hailed as a game-changer, what happened?, the Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice, SARS-CoV-2 infection and persistence in the human body and brain at autopsy, long-term cardiovascular outcomes of COVID-19, and how heart-disease risk soars after COVID — even with a mild case. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Infectiousness of breakthrough infections & reinfections during Omicron wave (Nature) Virological characteristics of the SARS-CoV-2 XBB variant (bioRxiv) Antibody evasion properties of BQ and XBB subvariants (Cell) Comparative effectiveness of third doses of mRNA vaccines in US veterans (Nature) Time to negative PCR conversion among high-risk patients treated by Sotrovimab or Nirmatrelvir (CMI) Paxlovid patient eligbiliity screening checklist (FDA) COVID drug Paxlovid was hailed as a game-changer. What happened? (Nature) Fc-effector function of COVID-19 convalescent plasma contributes to treatment efficacy (Cell) SARS-CoV-2 infection and persistence in the human body and brain at autopsy (Nature) Long-term cardiovascular outcomes of COVID-19 (Nature) Heart-disease risk soars after COVID (Nature) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 972 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update Dr. Griffin discusses Dr. Griffin discusses progress toward poliomyelitis eradication in Afghanistan, reduced risk for Mpox after receipt of 1 or 2 doses of JYNNEOS vaccine compared with risk among unvaccinated persons, reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters, authorized updated (Bivalent) COVID-19 vaccines for children down to 6 months of age, low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine or a BA.5-bivalent booster, efficacy of antiviral agents against omicron subvariants BQ.1.1 and XBB, incidence of viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir, and the effectiveness of coronavirus disease 2019 (COVID-19) vaccine in the prevention of post–COVID-19 conditions. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Progress toward Poliomyelitis eradication in Afghanistan (CDC) Reduced risk for Mpox after receipt of 1 or 2 Doses of JYNNEOS vaccine (CDC) Reduced airborne transmission of BA.1 Omicron virus in Syrian hamsters (PLOS) Authorized bivalent vaccines for children down to 6 months of age (FDA) Low neutralization of BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine (Nature) Efficacy of antiviral agents against Omicron subvariants BQ.1.1 and XBB (NEJM) Viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir (JAMA) Paxlovid patient eligbiliity screening checklist (FDA) Effectiveness of COVID-19 vaccines in prevention of post–infection conditions (ASHE) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 964 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
America Out Loud PULSE with Dr. Vaughn & Dr. Tankersley – In addition to people experiencing the lack of effectiveness of these injections personally, even the data on the ‘new and improved' injection suggests the 'improved' portion of that slogan is just marketing. It appears “a bivalent mRNA vaccine targeting Omicron BA.4/BA.5 and an ancestral SARS-CoV-2 strain did not induce...
America Out Loud PULSE with Dr. Vaughn & Dr. Tankersley – In addition to people experiencing the lack of effectiveness of these injections personally, even the data on the ‘new and improved' injection suggests the 'improved' portion of that slogan is just marketing. It appears “a bivalent mRNA vaccine targeting Omicron BA.4/BA.5 and an ancestral SARS-CoV-2 strain did not induce...
In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Influenza incidence and vaccine effectiveness (CDC) Nirsevimab for prevention of RSV (NEJM) Severe Monkeypox in hospitalized patients (CDC) Reinfections with different SARS-CoV-2 Omicron subvariants (CDC) Impact of community masking on COVID-19 (Science) Vaccine elicits protective immunity against sarbecoviruses (Science) Antibody responses to bivalent mRNA vaccine booster shot (Biorxiv) Immunogenicity of bivalent mRNA vaccine boosters (Biorxiv) Long-term gastrointestinal sequelae following COVID-19 (CGH) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Evaluation of an automated text message–based program (JAMA) Melatonin assessed for effects on inflammatory markers in COVID patients (Heliyon) PAXLOVID patient eligibility screening checklist (FDA) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 951 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
10月28日一早我去打了莫德納BA.1雙價疫苗，做為我的第四劑。前面打的是AAM，離第三劑已經超過九個月。連流感疫苗也一起打了，一個左手一個右手。 我和大家說說我考量的點。請注意，我是中年男性，肥胖，沒有確診過，無疑的是有相當的重症風險因子。這對於多數沒有重症風險因子的20~49歲左右的朋友，甚至有確診過的朋友，可能不適用。 1.現在打新冠疫苗主要是為了防重症，而非防感染。因此我一直在等有沒有更多打三劑後重症保護力可以維持多久的資料。以英國資料來說，三劑防住院的保護力，六個月內約在85%，超過六個月會掉到60%。秀熙老師團隊近來有報導過幾個美國研究，數字可能更差一些。 2.以上打的都是原始株的疫苗。至於次世代疫苗，大家一定會問，應該要打台灣現有的BA.1雙價，還是昨天通過EUA很快也要來的BA.5雙價呢？很抱歉，我沒有資料可以回答你。這兩個疫苗，前者是用免疫橋接過的，後者甚至只有動物試驗的資料。這點到昨天台灣通過EUA還是沒有改變。 3.倒是最近連出了兩篇BA.5雙價疫苗做為第四劑，和打原始疫苗相比，產生的中和抗體其實差不多的研究。這讓滿多人失望了，雖然人數很少，有自然感染過的干擾等等，還需要看到更多研究的證實。九月以來世界上很多人都打了次世代疫苗，我相信再等久一點會有針對BA.5保護效益的報告。但到底可以維持多久，又是要時間才能證明的事情了。 4.還有個重點是，下一波可能造成大流行的BQ家族和XBB，到底是打BA.1雙價還是BA.5雙價好？也許再一個月左右，我相信資料都會出來。 5.我11月中去日本，要給個1~2週生成抗體，因此我沒時間等到BA.5雙價進來，或是等到更多資料了，所以我還是來打了BA.1雙價，已經離第三劑9個月，我想我防重症的保護力應該有所下降，不要再撐了！ 這次去日本又要待20天，可能沒有第二次幸運，還是有打有保佑，成為新四劑福音戰士吧。 我也兩年沒打流感疫苗了，因應今年可能發生的流感大流行，一左一右一次完成！理論上莫德納應該局部不良反應較大，因此選擇打在左手。一下就打完了，好快！護理師技術超讚，一邊和我閒聊說，孔醫師你去日本之後一堆youtuber好像說好一樣都衝去了，每天看別人出國覺得好鬱悶，我有點愧咎剛想出聲安慰他。結果就打完了！而且是兩手都打完了。 現在已經滿48小時了，右手從頭到尾幾乎沒有感覺。我打的是公費流感疫苗，無法選擇廠牌，有什麼打什麼，我去打的那一天準備的是國光疫苗。 左手的話從29日早上起床開始局部有一些酸痛，並沒有紅腫，如果以一到十分來說大概疼痛指數是3分吧。大概到晚上從高雄回來之後就好很多，30日大概只剩1分，31日幾乎消失。我沒有其他疲倦，頭痛，發燒等等症狀。 附帶一提，第二階段流感疫苗注射即將開跑，請符合資格的民眾，特別是過去兩三年完全沒有打過流感疫苗的朋友可以考慮施打。 第一篇，何大一團隊的研究 Antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot https://www.biorxiv.org/content/10.1101/2022.10.22.513349v1.full.pdf 第二篇 Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters https://www.biorxiv.org/content/10.1101/2022.10.24.513619v1.full.pdf 英國資料，出自第四十週的疫苗效益追蹤 https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1109618/vaccine-surveillance-report-week-40.pdf 本集由凱勝電訊贊助播出。感謝本節目的第一個乾爹！ 凱勝的eSIM卡網頁： https://bit.ly/3Sk4Nvj 04b讀者可直接九折！若沒有請手動輸入萬年優惠代碼 linshibi。 eSIM詳細的說明請見部落格文章！ https://linshibi.com/?p=40550 歡迎追蹤前台大感染科醫師。04b的發聲管道！ 我的電子名片 https://lit.link/linshibi 希望大家當我的種子教師，推廣正確的新冠衛教。科學防疫，不要只以恐懼防疫！ 歡迎贊助林氏璧孔醫師喝咖啡，讓我可以在這個紛亂的時代，繼續分享知識努力做正確新冠相關衛教。 https://pay.firstory.me/user/linshibi Powered by Firstory Hosting
SpaceTime with Stuart Gary | Astronomy, Space & Science News
SpaceTime Series 25 Episode 115*Discovery of two interstellar objects which reached the Earth Astronomers have confirmed that two meteors which burned up in Earth's atmosphere were both alien visitors from interstellar space.*NASA's new time lapse movie of the universeNASA's NEOWISE spacecraft has provided astronomers with a new time lapse movie of the universe showing how its evolved over the past decade.*New SpaceX record breaking launchSpaceX is continuing to set new records with an unprecedented 53 launches in 53 weeks.*Atlas V launches two satellitesA United Launch Alliance Atlas V rocket has carried two new telecommunications satellites into geostationary orbit.*The Science ReportNew COVID-19 Omicron BA.2.75.2 variant largely evades neutralizing antibodies and treatments.Fishing equipment is a major pollutant in the world's oceans.Study shows Neanderthals lived in small communities of around 20 individuals.Skeptics guide to telling science from pseudoscience.Listen to SpaceTime on your favorite podcast app with our universal listen link: https://spacetimewithstuartgary.com/listen For more SpaceTime and show links: https://linktr.ee/biteszHQ If you love this podcast, please get someone else to listen to. Thank you…To become a SpaceTime supporter and unlock commercial free editions of the show, gain early access and bonus content, please visit https://bitesz.supercast.com/ . Premium version now available via Spotify and Apple Podcasts.For more podcasts visit our HQ at https://biteszhq.com Your support is needed...SpaceTime is an independently produced podcast (we are not funded by any government grants, big organisations or companies), and we're working towards becoming a completely listener supported show...meaning we can do away with the commercials and sponsors. We figure the time can be much better spent on researching and producing stories for you, rather than having to chase sponsors to help us pay the bills.That's where you come in....help us reach our first 1,000 subscribers...at that level the show becomes financially viable and bills can be paid without us breaking into a sweat every month. Every little bit helps...even if you could contribute just $1 per month. It all adds up.By signing up and becoming a supporter at the $5 or more level, you get immediate access to over 280 commercial-free, double, and triple episode editions of SpaceTime plus extended interview bonus content. You also receive all new episodes on a Monday rather than having to wait the week out. Subscribe via Supercast (you get a month's free trial to see if it's really for you or not) ... and share in the rewards. Details at Supercast - https://bitesznetwork.supercast.tech/ Details at https://spacetimewithstuartgary.com or www.bitesz.com #astronomy #space #science #news #podcast
Infectious diseases expert Dr. John Zurlo joins The Health Nexus Podcast once again to provide the latest information on COVID-19, including how he would time getting the Omicron BA.5 bivalent vaccine and the flu shot if you're trying to avoid feeling potentially crummy. Also on the docket of topics: masking recommendations this flu season, whether we'll see a surge this fall/winter and much more on that new bivalent vaccine. We also get an update on the monkeypox virus affecting our region and Dr. Zurlo breaks down the recent polio outbreak. A top recommendation? Be sure your vaccine records are up to date. On COVID Is COVID-19 over? – 01:13 Is anyone still a COVID virgin? – 03:30 On bivalent COVID-19 vaccines – 04:18 Why you need the primary COVID vaccine – 05:10 Who is eligible for this booster? – 06:06 Was the bivalent booster tested on humans? – 06:35 What is the best time to get the booster? – 08:22 How long does immunity last? – 09:11 Do you need the booster if you already got the Omicron variant of COVID? – 10:03 Should we get the COVID booster and flu shot together? – 11:01 How long until immunity from the booster kicks in? – 11:46 Will we face a COVID surge this fall/winter? – 12:02 Tips on spacing out COVID booster and flu shot – 12:46 Should we be masking up this flu season? – 13:27 On Monkeypox Update on outbreak affecting the region – 15:26 Who should receive the monkeypox vaccine? (And its side effects) – 18:15 Best ways to protect yourself and community – 19:43 On Polio Dr. Zurlo on the recent polio outbreak and what caused it – 20:18 History of polio – 21:28 Getting the polio vaccine and if it's harmful to get it twice – 24:32 Listen and subscribe to The Health Nexus Podcast on podcast players: Spotify, Apple Podcasts, Podbean For more stories on COVID-19 and more, visit TheHealthNexus.org
En este estudio transversal de 63 mil 277 participantes realizado en un sitio de prueba comunitario sin cita previa, los pacientes informaron con mayor frecuencia síntomas del tracto respiratorio superior de COVID-19 durante el período Omicron BA.1 que los períodos pre-Delta y Delta, con diferencias según el estado de vacunación y la edad. Durante el período Omicron BA.1, 5 días después de la aparición de los síntomas, el 80 % de los participantes seguían dando positivo mediante una prueba rápida de antígeno.
En este estudio transversal de 63 mil 277 participantes realizado en un sitio de prueba comunitario sin cita previa, los pacientes informaron con mayor frecuencia síntomas del tracto respiratorio superior de COVID-19 durante el período Omicron BA.1 que los períodos pre-Delta y Delta, con diferencias según el estado de vacunación y la edad. Durante el período Omicron BA.1, 5 días después de la aparición de los síntomas, el 80 % de los participantes seguían dando positivo mediante una prueba rápida de antígeno.
Coronavirus Update #70 GOOD NEWS: This information is so important to help us all understand risk. Stratified risk is the only true way to measure personal risk. Let us look at some CDC data from the spring Omicron BA.1 and .2 spikes versus the fall 2021 delta wave. Median age of hospitalization has increased from 60 years old with Delta to 64 with BA.1 and 71 with BA.2. Any underlying medical condition associated with hospitalization increased from 89% with Delta to 92% with BA.1 to 95% with BA.2 respectively. Length of hospital stay decreased from 4.8 to 3.9 to 3.3 days. ICU admission was down from 24% to 18% to 13% of admitted patients. Mechanical ventilation decreased from 14% to 8% to 6% of admitted patients. And Finally, death from 12% to 8% to 5% overall. What we can glean from this data set is very clear. With successive SARS2 mutations coupled to increased population based exposure to virus via infection or vaccine, we are now seriously in a reduced risk state unless you are older than 65 years with a comorbid disease or younger than 65 with a serious disease. 95% of hospitalizations were related to a comorbid disease regardless of age. The other big takeaway was this: if you are in this high risk group, getting every available booster is vital to your survival based on the risk reduction data. For everybody else, the data is clear, you are ok - to boost or not to boost is up to you. But, absolutely work on your general health. To your health, Dr. M
In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vaccinated and unvaccinated household contacts during replacement of delta with omicron variant, breakthrough infection by SARS-CoV-2 delta and omicron variants elicited immune response comparable to mRNA booster vaccination, interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses, further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants, short-course early outpatient Remdesivir prevents severe disease due to COVID-19 in organ transplant recipients during the Omicron BA.2 wave, effectiveness of Molnupiravir in high risk patients, and primary care and a distinct symptom pattern for long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position with Amy Rosenfeld (pdf) Support MicrobeTV with a Spike t-shirt at Vaccinated.US Increase in Acute Respiratory illnesses among children and adolescents (CDC) Estimates of Monkeypox incubation period, generation time, reproduction number (CDC) Rapid increase in suspected SARS-CoV-2 reinfections (CDC) Infection prevention and control recommendations for healthcare providers (CDC) SARS-CoV-2 attack rate in vaccinated and unvaccinated household contacts (CDC) Breakthrough Infection by variants elicited immune response comparable to vaccine (JID) Interval between prior SARS-CoV-2 infection and booster vaccination impacts (CELL) Humoral immunity evasion of BA.4 and BA.5 subvariants (The Lancet) Outpatient Remdesivir prevents severe disease in organ transplant recipients (Am J Transplant) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Effectiveness of Molnupiravir in high risk patients (CID) Update on Long COVID for primary care (BMJ) Distinct symptom pattern emerges for COVID-19 long-haul (Scientific Reports) Dr. Griffin's treatment guide (pdf) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 941 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
This is Garrison Hardie with your CrossPolitic Daily Newsbrief for Monday, August 29th, 2022. I hope you had an excellent weekend of rest, and worship with you and yours, so without further adieu, here’s what you may have missed over the weekend! https://www.theblaze.com/news/covid-booster-shots-omicron-fda FDA to authorize new COVID booster shots for Omicron before trials on humans, will instead rely on testing on mice The Food and Drug Administration (FDA) is expected to authorize new COVID-19 booster shots this week. The booster shots will be released months before trials on humans are completed, according to a new report. New COVID-19 booster shots that target the latest Omicron variant will be approved by the FDA this week, the Wall Street Journal reported. The new booster shot will be "bivalent" – which means it can target the original COVID-19 strain and the Omicron BA.5 subvariant. The booster shot will likely be available to Americans despite not having been tested on humans. Instead, the FDA will rely on testing on mice, data from current COVID-19 vaccines, and earlier iterations of boosters. The Wall Street Journal noted, "The Food and Drug Administration is expected to authorize new COVID-19 booster shots this week without a staple of its normal decision-making process: data from a study showing whether the shots were safe and worked in humans." FDA Commissioner Robert Califf issued a statement on Twitter regarding how the government agency will likely make a decision in granting emergency use authorization (EUA) for booster shots from Moderna and Pfizer. "FDA will rely on the totality of the available evidence in making a decision, including: Clinical trial data from other bivalent mRNA COVID-19 boosters RWE from current COVID-19 vaccines administered to millions of people, non-clinical data for the bivalent BA.4/5 vaccines, bivalent and multivalent vaccines are very common and modifying a vaccine to include different virus strains often does not require a change in other ingredients," Califf said on Twitter. Earlier this month, White House COVID-19 Response Coordinator Dr. Ashish Jha expected the boosters to be available by "early to mid-September." https://www.theepochtimes.com/3-dead-after-shooter-opens-fire-at-oregon-shopping-center_4695212.html?utm_source=partner&utm_campaign=BonginoReport In Oregon, tragic news, as 3 Dead After Shooter Opens Fire at Oregon Shopping Center A gunman armed with an AR-15-style rifle opened fire in a shopping center in Bend, Oregon, on Sunday evening, killing at least two people, authorities have confirmed. An individual who is believed to be the shooter was also found dead at the scene, police said, taking the death toll to three. Officers and emergency medics responded to multiple 911 calls of shots being fired at the Forum Shopping Center in Brend, which is approximately 160 miles southeast of Portland, Oregon, at about 7:04 p.m. Officials believe the shooter, who was only identified as a male, entered from a residential area behind the shopping center and moved through the parking lot while shooting rounds from an AR-15-style rifle. When officers arrived at the grocery store, police believe shots were still being fired, Krantz said. Officers found the suspected shooter dead inside the store. The investigation into the shooting is still ongoing, Krantz said, and multiple agencies are involved including the FBI. https://www.foxbusiness.com/politics/gov-glenn-youngkin-vows-stop-ridiculous-state-ban-gas-vehicles Oh look! A governor with some brains! Take note Newsome & Inslee, Gov. Glenn Youngkin vows to stop 'ridiculous' state ban on gas vehicles Republican Virginia Gov. Glenn Youngkin is working to dismantle Virginia's push toward electric vehicles, calling the move "ridiculous" in a Sunday statement. Virginia's former governor, Democrat Ralph Northam, signed legislation in 2021 tying the state's emissions policies to the California Air Resources Board. The board has imposed a regimen to eliminate the sale of gas and diesel vehicles by 2035, forcing Virginia to do the same thanks to the 2021 law. "In an effort to turn Virginia into California, liberal politicians who previously ran our government sold Virginia out by subjecting Virginia drivers to California vehicle laws," Youngkin wrote in a statement on Twitter. "Now, under that pact, Virginians will be forced to adopt the California law that prohibits the sale of gas and diesel-fueled vehicles." "I am already at work to prevent this ridiculous edict from being forced on Virginians. California’s out of touch laws have no place in our Commonwealth," he continued. Youngkin already has support for the move from the Republican-held House of Delegates. "House Republicans will advance legislation in 2023 to put Virginians back in charge of Virginia’s auto emission standards and its vehicle marketplace. Virginia is not, and should not be, California," House Speaker Todd Gilbert said in a statement. Northam and his fellow Democrats passed the legislation when the party held full control of the Virginia government last year. Club Membership Plug: Let’s stop and take a moment to talk about Fight Laugh Feast Club membership. By joining the Fight Laugh Feast Army, not only will you be aiding in our fight to take down secular & legacy media; but you’ll also get access to content placed in our Club Portal, such as past shows, all of our conference talks, and EXCLUSIVE content for club members that you won’t be able to find anywhere else. Lastly, you’ll also get discounts for our conferences… so if you’ve got $10 bucks a month to kick over our way, you can sign up now at flfnetwork.com https://www.breitbart.com/asia/2022/08/28/taliban-conducting-door-to-door-raids-to-confiscate-guns/ Members of Afghanistan’s Taliban conducted door-to-door raids of homes in the northern city of Mazar-e-Sharif on Thursday in part to search for and confiscate weapons, including firearms, deemed “illegal” by the terror group, which seized control of Afghanistan’s government in August 2021, the Kabul-based Khaama Press News Agency reported. The raids took place on the morning of August 25 in Mazar-e-Sharif, which is the capital of Afghanistan’s Balkh province, Khaama Press reported citing unnamed sources. The news agency said Taliban spokesman Asif Waziri, who serves Balkh’s “office of the chief of police” confirmed the raids in the northern capital. “Taliban forces are conducting door-to-door searches in an effort to combat ISIS, obtain state weapons and collect undocumented guns, as well as track down suspected criminals,” the Taliban spokesman added. Waziri referenced the Islamic State of Iraq and Syria (ISIS), which is an international jihadist terror group present in Afghanistan in the form of an offshoot called ISIS-Khorasan Province (ISIS-K). ISIS-K claimed responsibility for a deadly suicide bombing at Kabul’s Hamid Karzai International Airport on August 26, 2021, that killed 13 U.S. servicemembers and hundreds of Afghans. The attack took place as the administration of U.S. President Joe Biden oversaw a chaotic withdrawal of American troops from Afghanistan after the Taliban seized control of Kabul, the nation’s seat of government, on August 15, 2021. The Taliban had previously ruled Kabul from 1996 to 2001 before Washington launched a nearly 20-year-long War in Afghanistan in late 2001 that ousted the Sunni Islam-based terror group from the capital and replaced it with a U.S.-backed Afghan government administration. In a reversal of the action almost two decades later, the Taliban reconquered Kabul last summer and have since reestablished sharia, or Islamic law, as the basis of Afghanistan’s legal system. Armored Republic The Mission of Armored Republic is to Honor Christ by equipping Free Men with Tools of Liberty necessary to preserve God-given rights. In the Armored Republic there is no King but Christ. We are Free Craftsmen. Body Armor is a Tool of Liberty. We create Tools of Liberty. Free men must remain ever vigilant against tyranny wherever it appears. God has given us the tools of liberty needed to defend the rights He bestowed to us. Armored Republic is honored to offer you those Tools. Visit them, at ar500armor.com https://townhall.com/tipsheet/mattvespa/2022/08/29/brace-yourselves-we-might-need-to-send-troops-back-to-afghanistan-n2612341 Speaking of Afghanistan, Brace Yourselves: We Might Need to Send Troops Back to Afghanistan It doesn’t seem like a question of “if,” but “when” we redeploy troops to Afghanistan again amid rising terrorism concerns. This security situation wasn’t an item that caught us off-guard. It didn’t sneak up on us—it’s just another consequence of Joe Biden’s destructive policies. For all his time in DC, it’s still amazing that he remains one of the worst foreign policy minds in American politics. The Delaware liberal has been wrong on every significant American foreign policy effort for the past 40 years, and this Afghanistan pickle is no different. On Fox News Sunday, retired Gen. Kenneth F. McKenzie Jr. admitted that going back to Afghanistan, the graveyard of empires, was only a matter of time, given the increased activities of radical Islamic terrorists. McKenzie was the last commander of US-NATO forces in Afghanistan before our shambolic withdrawal. The Council of Foreign Relations had a detailed memorandum about the rising terror threat and how, unsurprisingly, the Taliban being allies of groups like al-Qaeda, have given their terror pals a lifeline to conduct their global campaign of jihad. The nation’s third-world dynamics and failing state status also serve as a magnet for terror groups. Genderal McKenzie Jr. was asked: “Do you think troops will have to be sent back to Afghanistan?” He responded: “That’s a difficult question…the threat is growing in Afghanistan, and it's merely a matter of time.” https://www.dailywire.com/news/libs-of-tiktok-locked-out-of-twitter-again Oh look, censorship is back! Libs of TikTok Locked Out of Twitter – Again Twitter reportedly blocked the popular Libs of TikTok account on Saturday, keeping its owner from posting or logging in over alleged violations of the social media platform’s guidelines. Libs of TikTok has become a prevalent Twitter account over its posts that share examples of far-left videos from TikTok, including topics like LGBT activism, critical race theory, and public education issues. Babylon CEO Seth Dillon shared a screenshot of the “hateful conduct” message the Libs of TikTok account claimed to have received. “Hi Libs of TikTok, your account, @libsoftiktok has been locked for violating the Twitter rules,” the message read. “You may not promote violence against, threaten, or harass other people on the basis of race, ethnicity, national origin, sexual orientation, gender, gender identity, religious affiliation, age, disability, or serious disease,” the message added. “Please note that repeated violations may lead to a permanent suspension of your account. Proceed to Twitter now to fix the issue with your account.” The message did not mention the particular post or posts that led to the locked-out account. One of the account’s last messages before being locked out was posted on Thursday. The post included audio that claimed that the Children’s National Hospital performed “gender-affirming” hysterectomies on minors, including those 16 years old and younger. It’s not the first time the popular account has been targeted in recent weeks. Libs of TikTok was permanently suspended from Facebook just one week earlier. Now we gotta wrap up today’s newsbrief with my favorite topic… sports! https://www.breitbart.com/sports/2022/08/28/watch-aaron-rodgers-says-nfl-stooges-threatened-players-their-jobs-vaccines/ Green Bay Packers’ quarterback, Aaron Rodgers is at it again! Aaron Rodgers Says NFL ‘Stooges’ Threatened Players with Their Jobs over Vaccines Another revelation by Green Bay Packers QB Aaron Rodgers in his interview with Joe Rogan revealed how the NFL threatened players by holding their jobs hostage unless they got vaccinated. During the August 27 Joe Rogan podcast in which Rodgers admitted that he purposefully misled the media on his vaccination status, Rodgers also blasted the NFL for its efforts to force players to take the jab. Rodgers slammed the NFL for “virtue signaling” over the vax and added that the league sent out “stooges” to force compliance. https://twitter.com/i/status/1563713875421315075 - Play Video 0:05- LANGUAGE WARNING Rodgers said that the teams were bullied to force compliance and were told that they would have to forfeit games if they had a certain number of players and staffers out with positive COVID results. The league began telling teams of the forfeit rule in July of 2021. Rodgers added that the NFL told players that they would also sacrifice their pay for any forfeited games as another way to force compliance. Ya know, Aaron Rodgers has annoyed me in the past, but I gotta give him props here for having a spine… he and Novak Djokovic, who by the way, isn’t allowed to play at the U.S. Open this year because of his vaccination status. This after he JUST WON Wimbledon… Oh interestingly enough… Moderna, is a sponsor at the U.S. Open this year… Coincidence? I’ll let you decide. This has been Garrison Hardie with your CrossPolitic Daily News Brief. If you liked the show, hit that share button down below. If you want to sign up for a club membership, then sign up for our conference with that club discount, and THEN sign up for a magazine, you can do all of that at fightlaughfeast.com. And as always, if you’d like to email me a news story, ask about our conference, or become a corporate partner of CrossPolitic, email me, at garrison@fightlaughfeast.com. For CrossPolitic News… I’m Garrison Hardie. Have a great day, and Lord bless!
This is Garrison Hardie with your CrossPolitic Daily Newsbrief for Monday, August 29th, 2022. I hope you had an excellent weekend of rest, and worship with you and yours, so without further adieu, here’s what you may have missed over the weekend! https://www.theblaze.com/news/covid-booster-shots-omicron-fda FDA to authorize new COVID booster shots for Omicron before trials on humans, will instead rely on testing on mice The Food and Drug Administration (FDA) is expected to authorize new COVID-19 booster shots this week. The booster shots will be released months before trials on humans are completed, according to a new report. New COVID-19 booster shots that target the latest Omicron variant will be approved by the FDA this week, the Wall Street Journal reported. The new booster shot will be "bivalent" – which means it can target the original COVID-19 strain and the Omicron BA.5 subvariant. The booster shot will likely be available to Americans despite not having been tested on humans. Instead, the FDA will rely on testing on mice, data from current COVID-19 vaccines, and earlier iterations of boosters. The Wall Street Journal noted, "The Food and Drug Administration is expected to authorize new COVID-19 booster shots this week without a staple of its normal decision-making process: data from a study showing whether the shots were safe and worked in humans." FDA Commissioner Robert Califf issued a statement on Twitter regarding how the government agency will likely make a decision in granting emergency use authorization (EUA) for booster shots from Moderna and Pfizer. "FDA will rely on the totality of the available evidence in making a decision, including: Clinical trial data from other bivalent mRNA COVID-19 boosters RWE from current COVID-19 vaccines administered to millions of people, non-clinical data for the bivalent BA.4/5 vaccines, bivalent and multivalent vaccines are very common and modifying a vaccine to include different virus strains often does not require a change in other ingredients," Califf said on Twitter. Earlier this month, White House COVID-19 Response Coordinator Dr. Ashish Jha expected the boosters to be available by "early to mid-September." https://www.theepochtimes.com/3-dead-after-shooter-opens-fire-at-oregon-shopping-center_4695212.html?utm_source=partner&utm_campaign=BonginoReport In Oregon, tragic news, as 3 Dead After Shooter Opens Fire at Oregon Shopping Center A gunman armed with an AR-15-style rifle opened fire in a shopping center in Bend, Oregon, on Sunday evening, killing at least two people, authorities have confirmed. An individual who is believed to be the shooter was also found dead at the scene, police said, taking the death toll to three. Officers and emergency medics responded to multiple 911 calls of shots being fired at the Forum Shopping Center in Brend, which is approximately 160 miles southeast of Portland, Oregon, at about 7:04 p.m. Officials believe the shooter, who was only identified as a male, entered from a residential area behind the shopping center and moved through the parking lot while shooting rounds from an AR-15-style rifle. When officers arrived at the grocery store, police believe shots were still being fired, Krantz said. Officers found the suspected shooter dead inside the store. The investigation into the shooting is still ongoing, Krantz said, and multiple agencies are involved including the FBI. https://www.foxbusiness.com/politics/gov-glenn-youngkin-vows-stop-ridiculous-state-ban-gas-vehicles Oh look! A governor with some brains! Take note Newsome & Inslee, Gov. Glenn Youngkin vows to stop 'ridiculous' state ban on gas vehicles Republican Virginia Gov. Glenn Youngkin is working to dismantle Virginia's push toward electric vehicles, calling the move "ridiculous" in a Sunday statement. Virginia's former governor, Democrat Ralph Northam, signed legislation in 2021 tying the state's emissions policies to the California Air Resources Board. The board has imposed a regimen to eliminate the sale of gas and diesel vehicles by 2035, forcing Virginia to do the same thanks to the 2021 law. "In an effort to turn Virginia into California, liberal politicians who previously ran our government sold Virginia out by subjecting Virginia drivers to California vehicle laws," Youngkin wrote in a statement on Twitter. "Now, under that pact, Virginians will be forced to adopt the California law that prohibits the sale of gas and diesel-fueled vehicles." "I am already at work to prevent this ridiculous edict from being forced on Virginians. California’s out of touch laws have no place in our Commonwealth," he continued. Youngkin already has support for the move from the Republican-held House of Delegates. "House Republicans will advance legislation in 2023 to put Virginians back in charge of Virginia’s auto emission standards and its vehicle marketplace. Virginia is not, and should not be, California," House Speaker Todd Gilbert said in a statement. Northam and his fellow Democrats passed the legislation when the party held full control of the Virginia government last year. Club Membership Plug: Let’s stop and take a moment to talk about Fight Laugh Feast Club membership. By joining the Fight Laugh Feast Army, not only will you be aiding in our fight to take down secular & legacy media; but you’ll also get access to content placed in our Club Portal, such as past shows, all of our conference talks, and EXCLUSIVE content for club members that you won’t be able to find anywhere else. Lastly, you’ll also get discounts for our conferences… so if you’ve got $10 bucks a month to kick over our way, you can sign up now at flfnetwork.com https://www.breitbart.com/asia/2022/08/28/taliban-conducting-door-to-door-raids-to-confiscate-guns/ Members of Afghanistan’s Taliban conducted door-to-door raids of homes in the northern city of Mazar-e-Sharif on Thursday in part to search for and confiscate weapons, including firearms, deemed “illegal” by the terror group, which seized control of Afghanistan’s government in August 2021, the Kabul-based Khaama Press News Agency reported. The raids took place on the morning of August 25 in Mazar-e-Sharif, which is the capital of Afghanistan’s Balkh province, Khaama Press reported citing unnamed sources. The news agency said Taliban spokesman Asif Waziri, who serves Balkh’s “office of the chief of police” confirmed the raids in the northern capital. “Taliban forces are conducting door-to-door searches in an effort to combat ISIS, obtain state weapons and collect undocumented guns, as well as track down suspected criminals,” the Taliban spokesman added. Waziri referenced the Islamic State of Iraq and Syria (ISIS), which is an international jihadist terror group present in Afghanistan in the form of an offshoot called ISIS-Khorasan Province (ISIS-K). ISIS-K claimed responsibility for a deadly suicide bombing at Kabul’s Hamid Karzai International Airport on August 26, 2021, that killed 13 U.S. servicemembers and hundreds of Afghans. The attack took place as the administration of U.S. President Joe Biden oversaw a chaotic withdrawal of American troops from Afghanistan after the Taliban seized control of Kabul, the nation’s seat of government, on August 15, 2021. The Taliban had previously ruled Kabul from 1996 to 2001 before Washington launched a nearly 20-year-long War in Afghanistan in late 2001 that ousted the Sunni Islam-based terror group from the capital and replaced it with a U.S.-backed Afghan government administration. In a reversal of the action almost two decades later, the Taliban reconquered Kabul last summer and have since reestablished sharia, or Islamic law, as the basis of Afghanistan’s legal system. Armored Republic The Mission of Armored Republic is to Honor Christ by equipping Free Men with Tools of Liberty necessary to preserve God-given rights. In the Armored Republic there is no King but Christ. We are Free Craftsmen. Body Armor is a Tool of Liberty. We create Tools of Liberty. Free men must remain ever vigilant against tyranny wherever it appears. God has given us the tools of liberty needed to defend the rights He bestowed to us. Armored Republic is honored to offer you those Tools. Visit them, at ar500armor.com https://townhall.com/tipsheet/mattvespa/2022/08/29/brace-yourselves-we-might-need-to-send-troops-back-to-afghanistan-n2612341 Speaking of Afghanistan, Brace Yourselves: We Might Need to Send Troops Back to Afghanistan It doesn’t seem like a question of “if,” but “when” we redeploy troops to Afghanistan again amid rising terrorism concerns. This security situation wasn’t an item that caught us off-guard. It didn’t sneak up on us—it’s just another consequence of Joe Biden’s destructive policies. For all his time in DC, it’s still amazing that he remains one of the worst foreign policy minds in American politics. The Delaware liberal has been wrong on every significant American foreign policy effort for the past 40 years, and this Afghanistan pickle is no different. On Fox News Sunday, retired Gen. Kenneth F. McKenzie Jr. admitted that going back to Afghanistan, the graveyard of empires, was only a matter of time, given the increased activities of radical Islamic terrorists. McKenzie was the last commander of US-NATO forces in Afghanistan before our shambolic withdrawal. The Council of Foreign Relations had a detailed memorandum about the rising terror threat and how, unsurprisingly, the Taliban being allies of groups like al-Qaeda, have given their terror pals a lifeline to conduct their global campaign of jihad. The nation’s third-world dynamics and failing state status also serve as a magnet for terror groups. Genderal McKenzie Jr. was asked: “Do you think troops will have to be sent back to Afghanistan?” He responded: “That’s a difficult question…the threat is growing in Afghanistan, and it's merely a matter of time.” https://www.dailywire.com/news/libs-of-tiktok-locked-out-of-twitter-again Oh look, censorship is back! Libs of TikTok Locked Out of Twitter – Again Twitter reportedly blocked the popular Libs of TikTok account on Saturday, keeping its owner from posting or logging in over alleged violations of the social media platform’s guidelines. Libs of TikTok has become a prevalent Twitter account over its posts that share examples of far-left videos from TikTok, including topics like LGBT activism, critical race theory, and public education issues. Babylon CEO Seth Dillon shared a screenshot of the “hateful conduct” message the Libs of TikTok account claimed to have received. “Hi Libs of TikTok, your account, @libsoftiktok has been locked for violating the Twitter rules,” the message read. “You may not promote violence against, threaten, or harass other people on the basis of race, ethnicity, national origin, sexual orientation, gender, gender identity, religious affiliation, age, disability, or serious disease,” the message added. “Please note that repeated violations may lead to a permanent suspension of your account. Proceed to Twitter now to fix the issue with your account.” The message did not mention the particular post or posts that led to the locked-out account. One of the account’s last messages before being locked out was posted on Thursday. The post included audio that claimed that the Children’s National Hospital performed “gender-affirming” hysterectomies on minors, including those 16 years old and younger. It’s not the first time the popular account has been targeted in recent weeks. Libs of TikTok was permanently suspended from Facebook just one week earlier. Now we gotta wrap up today’s newsbrief with my favorite topic… sports! https://www.breitbart.com/sports/2022/08/28/watch-aaron-rodgers-says-nfl-stooges-threatened-players-their-jobs-vaccines/ Green Bay Packers’ quarterback, Aaron Rodgers is at it again! Aaron Rodgers Says NFL ‘Stooges’ Threatened Players with Their Jobs over Vaccines Another revelation by Green Bay Packers QB Aaron Rodgers in his interview with Joe Rogan revealed how the NFL threatened players by holding their jobs hostage unless they got vaccinated. During the August 27 Joe Rogan podcast in which Rodgers admitted that he purposefully misled the media on his vaccination status, Rodgers also blasted the NFL for its efforts to force players to take the jab. Rodgers slammed the NFL for “virtue signaling” over the vax and added that the league sent out “stooges” to force compliance. https://twitter.com/i/status/1563713875421315075 - Play Video 0:05- LANGUAGE WARNING Rodgers said that the teams were bullied to force compliance and were told that they would have to forfeit games if they had a certain number of players and staffers out with positive COVID results. The league began telling teams of the forfeit rule in July of 2021. Rodgers added that the NFL told players that they would also sacrifice their pay for any forfeited games as another way to force compliance. Ya know, Aaron Rodgers has annoyed me in the past, but I gotta give him props here for having a spine… he and Novak Djokovic, who by the way, isn’t allowed to play at the U.S. Open this year because of his vaccination status. This after he JUST WON Wimbledon… Oh interestingly enough… Moderna, is a sponsor at the U.S. Open this year… Coincidence? I’ll let you decide. This has been Garrison Hardie with your CrossPolitic Daily News Brief. If you liked the show, hit that share button down below. If you want to sign up for a club membership, then sign up for our conference with that club discount, and THEN sign up for a magazine, you can do all of that at fightlaughfeast.com. And as always, if you’d like to email me a news story, ask about our conference, or become a corporate partner of CrossPolitic, email me, at garrison@fightlaughfeast.com. For CrossPolitic News… I’m Garrison Hardie. Have a great day, and Lord bless!
Coronavirus Update 67 Natural infection provides a much better route to transmission protection than intramuscular systemic vaccination because of the induction of mucosal immunity via IgA and tissue resident T cells. (Tang et. al. 2022) If you can tolerate a natural infection without much morbidity, this seems to be a reasonable choice at this time. This is especially important now with the immune escaping variants of Omicron lineage and the reality of the current vaccine booster pool is lackluster in its effect on transmission. This calculus may change dramatically with a newer Omicron BA.5 specific vaccine that is in the works. And much more this week! Dr. M
We've enjoyed a few months with subdued pushes for medical tyranny, but the ugly head of totalitarianism is rising again in the form of Pandemic Panic Theater 2.0. Omicron BA.5, Monkeypox, Polio, and Hemorrhagic Fever are all in the news just in time for midterm elections and The Great Reset push.
Host: Mindy McCulley, Extension Specialist for Instructional Support, Family and Consumer Sciences Extension, University of Kentucky Guest: Dr. Natalie Jones, Extension Specialist for Family Health Season 5, Episode 3 You may have noticed that COVID cases are on the rise across Kentucky and the nation. On this episode of Talking FACS, Dr. Natalie Jones shares information about the variants (Omicron BA.4 and Omicron BA.5) that are responsible for many of the latest rounds of infections and what everyone can do to protect themselves and those around them. She also discuss vaccine and booster eligibility. Connect with FCS Extension: Kentucky Extension Offices UK FCS Website FCS Facebook FCS Instagram
Dr. K covers what to know about Omicron BA.5, the data on 1st and 2nd boosters, what to know about Paxlovid rebound, what precautions she recommends for aging adults, and more. The post 129 COVID Update for Aging Adults (7.21.22 Edition) appeared first on Better Health While Aging.
In this week's Lunch and Learn with Dr. Berry podcast, we bring you another rendition of our COVID-19 update. We're discussing the most recent information on COVID-19, particularly the most recent omicron variant BA.5, which has quickly replaced older strains as the one that predominates in this country. Today, I'm going to discuss why the BA.5 area has quickly risen to the top strain in this nation in less than three weeks and why we should be concerned. This week's episode will focus on; Recent COVID-19 update What is the BA.5 COVID-19 variant Symptoms of the Ba.5 COVID-19 variant What is different about this variant How you should prepare to deal with this new variant Why you should be worried Links/Resources: Dr. Berry's Website DrBerryPierreTV Dr. Pierre's Healthchecks Dr. Berry's Twitter Dr. Berry's Instagram Dr. Berry's Clubhouse Dr. Berry's TikTok page What is the BA.2 COVID Variant? CDC COVID Data Tracker The Omicron BA.5 variant is driving COVID reinfections across the US. Sponsors: Lunch and Learn Community Online Store (code Empower10) Pierre Medical Consulting (If you are looking to expand your social reach and make your process automated then Pierre Medical Consulting is for you) Dr. Pierre's Resources – These are some of the tools I use to become successful using social media My Amazon Store – Check out all of the book recommendations you heard in the episode
Omicron BA.5 is the new dominant COVID strain in the U.S. New mutations. A new set of questions. Dr. Ashish Jha, Professor Marlene Wolfe and Dr. Amesh Adalja join Kimberly Atkins Stohr.
Happy Friday Jr. everyone, this is Garrison Hardie stepping in for ya boy, the Chocolate Knox, for Thursday, July 14th, 2022. Before we take a dive into the news, lets talk about our conference! FLF Conference Plug: Folks, our upcoming Fight Laugh Feast Conference is just about 3-months away from happening in Knoxville TN, October 6-8! Don't miss beer & psalms, our amazing lineup of speakers which includes George Gilder, Jared Longshore, Pastor Wilson, Dr. Ben Merkle, Pastor Toby, and we can’t say yet…also dont miss our awesome vendors, meeting new friends, and stuff for the kids too…like jumpy castles and accidental infant baptisms! Also, did you know, you can save money, by signing up for a Club Membership. So, go to FightLaughFeast.com and sign up for a club membership and then register for the conference with that club discount. We can’t wait to fellowship, sing Psalms, and celebrate God’s goodness in Knoxville October 6-8. Now as we talk about heading into our conference in October, that’s heading into the winter time right? Reformation Day, Thanksgiving, Christmas… to me, that’s just really the best time of year. Getting to spend time with your family, the weather is getting colder, (as a ginger that’s great), and we get to celebrate the birth of our savior, Jesus Christ. Well, not if our government has any say over it!!! https://unherd.com/thepost/brace-for-winter-lockdowns/ Brace for winter lockdowns This is from Unherd.com. Many of those who opposed lockdowns for the pandemic, predicted that the policy — if normalised — could one day be taken advantage of by opportunistic political forces to deal with almost any crisis. It was, as Lord Sumption once suggested, a potential pathway to authoritarianism. “If we confer despotic powers on government to deal with perils, which are an ordinary feature of human existence, we will end up doing it most or all of the time,” he wrote in November 2021. Well, we are now facing just such a crisis. And there is a not insignificant chance that lockdowns might be revived, not just as a knee-jerk reaction to cope with a prevailing health crisis, but also, troublingly, an economic one. The monkeypox health scare may have failed to get traction, but as Covid cases begin to rise again, the slow beat of pro-lockdown messaging is beginning to circle again in the mainstream media. For now, the public remains far from receptive. But this could change as soon as energy shortages and supply chain issues begin to bite this winter, which they surely will. The public has already been primed to believe that lockdowns were great for generating energy savings. We saw the evidence of that with our own eyes. Traffic jams disappeared. Oil prices went negative. Air pollution reversed. In the face of late Soviet-style chaos on the streets, unconstrained inflation, not enough electricity to heat the homes of the vulnerable, the prospect of order emanating from the “temporary” suspension of a market economy might seem appealing. It’s even easy to predict the messaging that might feel compelling: ‘Stay Home. Don’t queue. Save Energy.’ Or, ‘Bread and energy is cheap if you stay home!’ But here is why we must not fall for this line of logic. Planned economies are what got us into this mess to begin with. Covid, the war in Ukraine and sanctions against Russia may have all added accelerants to the fire, but the smoulders were burning ever since the 2008 global financial crisis nearly brought down the system. It’s just that the consequences of papering over the flaws in the system rather than properly addressing them only became visible in late 2021. It took 70 years for the communist system to fall apart under the weight of its own capital misallocation. We’ve managed to achieve it in about 14 years. At the heart of the problem is the poorly thought-out subsidisation of negative-sum business models propelled by excessive cheap money in the system. In the communist period, this sort of misdirection was the fault of state bureaucrats who had no idea about what people really wanted. This time it’s been driven by deep-pocketed Western venture capitalists who became convinced that outsized rents from monopoly interests could compensate for short-term non-profitability. That’s not to say the market economy is perfect or free of its own negative externalities. It definitely needs political guidance and a moral backbone to stay on course. But locking people down is not the answer. This only addresses the symptoms, not the cause. Our best path out of this mess is to keep the system as free as possible so that the people themselves can innovate their way out of trouble. Necessity, as they say, is the mother of invention. Allowing human ingenuity to thrive in a free system is our best chance to solve our economic woes. Wow… terrifying stuff. This is what CrossPolitic has been arguing for all along by the way, and maybe that’s a reason why we’ve been banned from Youtube time after time… also, this is another good reason to come to our conference by the way! Our topic seems pretty in line with the story no? https://www.mirror.co.uk/news/world-news/who-chief-urges-bring-back-27470930 WHO chief urges 'bring back face masks' as Covid pandemic 'nowhere near over' The World Health Organisation is urging governments to reinstate Covid measures like masking and ventilation as its leader speaks of concerns over an “increasing trend of deaths”. As the British government, along with many others of wealthy countries, have all but abandoned coronavirus restrictions, the WHO director-general Dr Tedros Adhanom Ghebreyesus has said the pandemic is “nowhere near over”. It comes as new ONS figures have today showed that more than 200,000 people in the UK have had Covid-19 recorded on their death certificate since the pandemic began. Infections and hospital admissions are once again on the rise, driven by the coronavirus subvariant Omicron BA.2. Experts have warned that new variants can re-infect even those with some form of antibody immunity, in a matter of weeks. Amid a spike in Covid transmission and increasing hospitalisations, Dr Ghebreyesus urged governments to “deploy tried and tested measures like masking, improved ventilation and test and treat protocols”. "I am concerned that cases of Covid-19 continue to rise - putting further pressure on stretched health systems and health workers," he said. One of the more concerning variants and subvariants being tracked by the WHO was BA.2.75, nicknamed the centaurus. Scientists believe the Covid strain, which was first discovered in May in India, may be able to spread rapidly and infect people regardless of immunity from vaccines and antibodies. Governments were now facing several “interlinked” challenges around their response to coronavirus, Dr Ghebreyesus said, including the Omicron sub-variants and reduced testing and sequencing. He went on to explain that there was a disconnect in Covid-19 risk perception between scientific communities, political leaders and the general public. Another challenge was communicating risk and building community trust in health tools, as well as public health social measures like masking, distancing and ventilation, he said. The pandemic was “nowhere near over”, he said, adding that we were in a better position than at the beginning of the pandemic to push back. While progress had been made in the form of tools preventing hospitalisations and deaths, these should not be taken for granted. Dr Ghebreyesus urged governments to regularly review and adjust their Covid-19 response plans based on changing situations. The idea of restrictions being brought back in the UK was raised on Tuesday if an increase in cases worsens the backlog facing the NHS. The WHO’s warning came just days after a SAGE advisor blasted the Tories for failing to take the urgent action needed to stop huge numbers of hospitalisations and unnecessary deaths. Britain could grind to a standstill as Covid-19 cases surge - but the government’s policy is to ‘shut your eyes and let it rip,’ Susan Michie has warned. Moving on, and back to our bad economy, https://www.yahoo.com/now/rents-us-rise-fastest-pace-161957394.html Rents in US Rise at Fastest Pace Since 1986, Buoying Inflation (Bloomberg) -- Rents rose in the US last month at the fastest pace since 1986, helping to propel overall inflation to a fresh four-decade high. An index measuring rent of a primary residence was 0.8% higher in June than the month before, an acceleration from the 0.6% increase recorded in May, according to the Labor Department’s report on consumer prices published Wednesday. In the 12 months through June, rents were up 5.8% Those costs are soaring across the country as would-be homebuyers get priced out by the fastest-rising mortgage rates in decades and slide back into the overcrowded rental market. But rent growth may be peaking as affordability concerns mount, and a surge in construction of new units is poised to start adding to the available inventory. The Labor Department measure tends to lag behind other estimates, so it is likely that rent increases will contribute to rising inflation in the consumer price index through the rest of this year, according to Mark Zandi, chief economist of Moody’s Analytics. “The big increase in CPI rents is catch-up with the consistent double-digit growth in market rents,” Zandi said. “The good news is that market rents appear to be topping out, as renters are not able to afford the higher rents and are balking. More rental supply is also coming, although this will take a year or two to have a meaningful impact on market rents.” Nearly 836,000 multifamily units are under construction, the most since 1973, according to Jay Parsons, chief economist at RealPage. But most new construction targets higher-income tenants and not the lower end, where supply shortages are most extreme, he said. Rents, along with a category known as owners’ equivalent rent that often moves in tandem, account for more than 30% of the consumer price index, giving them outsize weight in overall inflation trends. Given the close ties between rents and wages, the accelerating pace of increases will keep Federal Reserve officials on an aggressive tightening path. Average hourly earnings for production and nonsupervisory workers rose 6.4% in the 12 months through June and have generally outpaced rents since the pandemic began -- a reversal of the trend that prevailed throughout much of the economic expansion of the 2010s. But the gap has narrowed in recent months as increases in earnings have moderated and rental inflation has accelerated. You know, our economy may be weak, but you don’t want your children’s education to be weak either do you? That’s why you need to talk to our sponsors, Classical Conversations. Classical Conversations supports homeschooling parents by cultivating the love of learning through a Christian worldview in fellowship with other families. We provide a classical Christ-centered curriculum, local like-minded communities across the United States and in several countries, and we train parents who are striving to be great classical educators in the home. For more information and to get connected, please visit our website at ClassicalConversations.com. Again that’s ClassicalConversations.com. Before we go, it’s time for the topic that I love… sports! https://www.yahoo.com/news/lebron-james-says-brittney-griner-175538850.html LeBron James says Brittney Griner should question returning to United States NBA star LeBron James questioned if WNBA star Brittney Griner should return to the United States whenever she is released from her incarceration in Russia. The Los Angeles Lakers star made the comment about the Phoenix Mercury star in a trailer for his show, The Shop, which is scheduled to air on Friday on Uninterrupted's YouTube channel. "Now, how can she feel like America has her back?" James said. "I would be feeling like, 'Do I even want to go back to America?'" James later took to Twitter to clarify his comments. "My comments on 'The Shop' regarding Brittney Griner wasn’t knocking our beautiful country," he tweeted. "I was simply saying how she’s probably feeling emotionally along with so many other emotions, thoughts, etc inside that cage she’s been in for over 100+ days! Long story short #BringHerHome" This isn't the first time James has commented on Griner's situation. In June, he demanded action from Joe Biden and Kamala Harris to bring Griner back to the United States, although now he apparently wonders if she should come back to the U.S. "We need to come together and help do whatever we possibly can to bring BG home quickly and safely!!" James posted on Twitter. "Our voice as athletes is stronger together." Griner has been detained since Feb. 17 after vaping cartridges containing oil derived from cannabis were allegedly found in her luggage while going through an airport outside of Moscow. Interestingly, Phoenix Mercury coach Vanessa Nygaard recently wondered if Griner's situation in Russia would be resolved already if it were James, not Griner that was detained. "If it was LeBron, he'd be home, right?" Nygaard asked. "It's a statement about the value of women. It's a statement about the value of a black person. It's a statement about the value of a gay person. All of those things. We know it, and so that's what hurts a little more." Wait a minute, wait a minute… what is a woman? Is Nygaard a biologist? Here’s the deal, I don’t want Griner to rot in a Russain jail, despite her hateful and uneducated view of America, or the fact that she’s rejecting God’s natural law for marriage, or the fact that she thinks she could beat DeMarcus Cousins in a game of 1-on-1… you get the idea. Keeping image bearers of God in cages is wrong and wicked, and we need to get back to a Biblical form of justice… so here’s hoping she’s out soon. This has been your CrossPolitic Daily News Brief. If you liked the show, hit that share button for me would ya? If you want to sign up for our conference, a magazine subscription, or become a club member… you can do all of that at fightlaughfeast.com! And as always, if you’d like to become a corporate partner of CrossPolitic, let’s talk. Email me, at garrison@fightlaughfeast.com. For CrossPolitic News, I’m Garrison Hardie. Have a great day, and Lord bless.
U.S. inflation hit a 40-year-high in the month of June, rising to 9.1 percent. On Wednesday, President Biden addressed Americans who have been grappling with high prices at the grocery store and gas pump, saying the latest “inflation reading is unacceptably high” and vowing to give the Fed “the room it needs to help it combat inflation.” The Fed will continue its balancing act of implementing interest rate hikes without tilting the economy toward a recession. Senior Writer for The Wall Street Journal Jon Hilsenrath explains how the inflation peak is higher than experts hoped, the Fed's likely plan until inflation is under control and Americans' current outlook on the economy. The new Omicron BA.5 subvariant has emerged and is now the dominant strain of Covid-19 in the U.S. Although both Covid cases and hospitalizations are back on the rise, many Americans no longer fear the virus and are taking their chances without masks and vaccines. Former U.S. Surgeon General Dr. Jerome Adams joins the Rundown to discuss the overall state of the pandemic, why it's important to assess your personal risk, and why vaccines are still beneficial despite the different variants of the virus. Plus, commentary by Opinion Editor for The Washington Times Charlie Hurt. Learn more about your ad choices. Visit megaphone.fm/adchoices
Happy Friday Jr. everyone, this is Garrison Hardie stepping in for ya boy, the Chocolate Knox, for Thursday, July 14th, 2022. Before we take a dive into the news, lets talk about our conference! FLF Conference Plug: Folks, our upcoming Fight Laugh Feast Conference is just about 3-months away from happening in Knoxville TN, October 6-8! Don't miss beer & psalms, our amazing lineup of speakers which includes George Gilder, Jared Longshore, Pastor Wilson, Dr. Ben Merkle, Pastor Toby, and we can’t say yet…also dont miss our awesome vendors, meeting new friends, and stuff for the kids too…like jumpy castles and accidental infant baptisms! Also, did you know, you can save money, by signing up for a Club Membership. So, go to FightLaughFeast.com and sign up for a club membership and then register for the conference with that club discount. We can’t wait to fellowship, sing Psalms, and celebrate God’s goodness in Knoxville October 6-8. Now as we talk about heading into our conference in October, that’s heading into the winter time right? Reformation Day, Thanksgiving, Christmas… to me, that’s just really the best time of year. Getting to spend time with your family, the weather is getting colder, (as a ginger that’s great), and we get to celebrate the birth of our savior, Jesus Christ. Well, not if our government has any say over it!!! https://unherd.com/thepost/brace-for-winter-lockdowns/ Brace for winter lockdowns This is from Unherd.com. Many of those who opposed lockdowns for the pandemic, predicted that the policy — if normalised — could one day be taken advantage of by opportunistic political forces to deal with almost any crisis. It was, as Lord Sumption once suggested, a potential pathway to authoritarianism. “If we confer despotic powers on government to deal with perils, which are an ordinary feature of human existence, we will end up doing it most or all of the time,” he wrote in November 2021. Well, we are now facing just such a crisis. And there is a not insignificant chance that lockdowns might be revived, not just as a knee-jerk reaction to cope with a prevailing health crisis, but also, troublingly, an economic one. The monkeypox health scare may have failed to get traction, but as Covid cases begin to rise again, the slow beat of pro-lockdown messaging is beginning to circle again in the mainstream media. For now, the public remains far from receptive. But this could change as soon as energy shortages and supply chain issues begin to bite this winter, which they surely will. The public has already been primed to believe that lockdowns were great for generating energy savings. We saw the evidence of that with our own eyes. Traffic jams disappeared. Oil prices went negative. Air pollution reversed. In the face of late Soviet-style chaos on the streets, unconstrained inflation, not enough electricity to heat the homes of the vulnerable, the prospect of order emanating from the “temporary” suspension of a market economy might seem appealing. It’s even easy to predict the messaging that might feel compelling: ‘Stay Home. Don’t queue. Save Energy.’ Or, ‘Bread and energy is cheap if you stay home!’ But here is why we must not fall for this line of logic. Planned economies are what got us into this mess to begin with. Covid, the war in Ukraine and sanctions against Russia may have all added accelerants to the fire, but the smoulders were burning ever since the 2008 global financial crisis nearly brought down the system. It’s just that the consequences of papering over the flaws in the system rather than properly addressing them only became visible in late 2021. It took 70 years for the communist system to fall apart under the weight of its own capital misallocation. We’ve managed to achieve it in about 14 years. At the heart of the problem is the poorly thought-out subsidisation of negative-sum business models propelled by excessive cheap money in the system. In the communist period, this sort of misdirection was the fault of state bureaucrats who had no idea about what people really wanted. This time it’s been driven by deep-pocketed Western venture capitalists who became convinced that outsized rents from monopoly interests could compensate for short-term non-profitability. That’s not to say the market economy is perfect or free of its own negative externalities. It definitely needs political guidance and a moral backbone to stay on course. But locking people down is not the answer. This only addresses the symptoms, not the cause. Our best path out of this mess is to keep the system as free as possible so that the people themselves can innovate their way out of trouble. Necessity, as they say, is the mother of invention. Allowing human ingenuity to thrive in a free system is our best chance to solve our economic woes. Wow… terrifying stuff. This is what CrossPolitic has been arguing for all along by the way, and maybe that’s a reason why we’ve been banned from Youtube time after time… also, this is another good reason to come to our conference by the way! Our topic seems pretty in line with the story no? https://www.mirror.co.uk/news/world-news/who-chief-urges-bring-back-27470930 WHO chief urges 'bring back face masks' as Covid pandemic 'nowhere near over' The World Health Organisation is urging governments to reinstate Covid measures like masking and ventilation as its leader speaks of concerns over an “increasing trend of deaths”. As the British government, along with many others of wealthy countries, have all but abandoned coronavirus restrictions, the WHO director-general Dr Tedros Adhanom Ghebreyesus has said the pandemic is “nowhere near over”. It comes as new ONS figures have today showed that more than 200,000 people in the UK have had Covid-19 recorded on their death certificate since the pandemic began. Infections and hospital admissions are once again on the rise, driven by the coronavirus subvariant Omicron BA.2. Experts have warned that new variants can re-infect even those with some form of antibody immunity, in a matter of weeks. Amid a spike in Covid transmission and increasing hospitalisations, Dr Ghebreyesus urged governments to “deploy tried and tested measures like masking, improved ventilation and test and treat protocols”. "I am concerned that cases of Covid-19 continue to rise - putting further pressure on stretched health systems and health workers," he said. One of the more concerning variants and subvariants being tracked by the WHO was BA.2.75, nicknamed the centaurus. Scientists believe the Covid strain, which was first discovered in May in India, may be able to spread rapidly and infect people regardless of immunity from vaccines and antibodies. Governments were now facing several “interlinked” challenges around their response to coronavirus, Dr Ghebreyesus said, including the Omicron sub-variants and reduced testing and sequencing. He went on to explain that there was a disconnect in Covid-19 risk perception between scientific communities, political leaders and the general public. Another challenge was communicating risk and building community trust in health tools, as well as public health social measures like masking, distancing and ventilation, he said. The pandemic was “nowhere near over”, he said, adding that we were in a better position than at the beginning of the pandemic to push back. While progress had been made in the form of tools preventing hospitalisations and deaths, these should not be taken for granted. Dr Ghebreyesus urged governments to regularly review and adjust their Covid-19 response plans based on changing situations. The idea of restrictions being brought back in the UK was raised on Tuesday if an increase in cases worsens the backlog facing the NHS. The WHO’s warning came just days after a SAGE advisor blasted the Tories for failing to take the urgent action needed to stop huge numbers of hospitalisations and unnecessary deaths. Britain could grind to a standstill as Covid-19 cases surge - but the government’s policy is to ‘shut your eyes and let it rip,’ Susan Michie has warned. Moving on, and back to our bad economy, https://www.yahoo.com/now/rents-us-rise-fastest-pace-161957394.html Rents in US Rise at Fastest Pace Since 1986, Buoying Inflation (Bloomberg) -- Rents rose in the US last month at the fastest pace since 1986, helping to propel overall inflation to a fresh four-decade high. An index measuring rent of a primary residence was 0.8% higher in June than the month before, an acceleration from the 0.6% increase recorded in May, according to the Labor Department’s report on consumer prices published Wednesday. In the 12 months through June, rents were up 5.8% Those costs are soaring across the country as would-be homebuyers get priced out by the fastest-rising mortgage rates in decades and slide back into the overcrowded rental market. But rent growth may be peaking as affordability concerns mount, and a surge in construction of new units is poised to start adding to the available inventory. The Labor Department measure tends to lag behind other estimates, so it is likely that rent increases will contribute to rising inflation in the consumer price index through the rest of this year, according to Mark Zandi, chief economist of Moody’s Analytics. “The big increase in CPI rents is catch-up with the consistent double-digit growth in market rents,” Zandi said. “The good news is that market rents appear to be topping out, as renters are not able to afford the higher rents and are balking. More rental supply is also coming, although this will take a year or two to have a meaningful impact on market rents.” Nearly 836,000 multifamily units are under construction, the most since 1973, according to Jay Parsons, chief economist at RealPage. But most new construction targets higher-income tenants and not the lower end, where supply shortages are most extreme, he said. Rents, along with a category known as owners’ equivalent rent that often moves in tandem, account for more than 30% of the consumer price index, giving them outsize weight in overall inflation trends. Given the close ties between rents and wages, the accelerating pace of increases will keep Federal Reserve officials on an aggressive tightening path. Average hourly earnings for production and nonsupervisory workers rose 6.4% in the 12 months through June and have generally outpaced rents since the pandemic began -- a reversal of the trend that prevailed throughout much of the economic expansion of the 2010s. But the gap has narrowed in recent months as increases in earnings have moderated and rental inflation has accelerated. You know, our economy may be weak, but you don’t want your children’s education to be weak either do you? That’s why you need to talk to our sponsors, Classical Conversations. Classical Conversations supports homeschooling parents by cultivating the love of learning through a Christian worldview in fellowship with other families. We provide a classical Christ-centered curriculum, local like-minded communities across the United States and in several countries, and we train parents who are striving to be great classical educators in the home. For more information and to get connected, please visit our website at ClassicalConversations.com. Again that’s ClassicalConversations.com. Before we go, it’s time for the topic that I love… sports! https://www.yahoo.com/news/lebron-james-says-brittney-griner-175538850.html LeBron James says Brittney Griner should question returning to United States NBA star LeBron James questioned if WNBA star Brittney Griner should return to the United States whenever she is released from her incarceration in Russia. The Los Angeles Lakers star made the comment about the Phoenix Mercury star in a trailer for his show, The Shop, which is scheduled to air on Friday on Uninterrupted's YouTube channel. "Now, how can she feel like America has her back?" James said. "I would be feeling like, 'Do I even want to go back to America?'" James later took to Twitter to clarify his comments. "My comments on 'The Shop' regarding Brittney Griner wasn’t knocking our beautiful country," he tweeted. "I was simply saying how she’s probably feeling emotionally along with so many other emotions, thoughts, etc inside that cage she’s been in for over 100+ days! Long story short #BringHerHome" This isn't the first time James has commented on Griner's situation. In June, he demanded action from Joe Biden and Kamala Harris to bring Griner back to the United States, although now he apparently wonders if she should come back to the U.S. "We need to come together and help do whatever we possibly can to bring BG home quickly and safely!!" James posted on Twitter. "Our voice as athletes is stronger together." Griner has been detained since Feb. 17 after vaping cartridges containing oil derived from cannabis were allegedly found in her luggage while going through an airport outside of Moscow. Interestingly, Phoenix Mercury coach Vanessa Nygaard recently wondered if Griner's situation in Russia would be resolved already if it were James, not Griner that was detained. "If it was LeBron, he'd be home, right?" Nygaard asked. "It's a statement about the value of women. It's a statement about the value of a black person. It's a statement about the value of a gay person. All of those things. We know it, and so that's what hurts a little more." Wait a minute, wait a minute… what is a woman? Is Nygaard a biologist? Here’s the deal, I don’t want Griner to rot in a Russain jail, despite her hateful and uneducated view of America, or the fact that she’s rejecting God’s natural law for marriage, or the fact that she thinks she could beat DeMarcus Cousins in a game of 1-on-1… you get the idea. Keeping image bearers of God in cages is wrong and wicked, and we need to get back to a Biblical form of justice… so here’s hoping she’s out soon. This has been your CrossPolitic Daily News Brief. If you liked the show, hit that share button for me would ya? If you want to sign up for our conference, a magazine subscription, or become a club member… you can do all of that at fightlaughfeast.com! And as always, if you’d like to become a corporate partner of CrossPolitic, let’s talk. Email me, at garrison@fightlaughfeast.com. For CrossPolitic News, I’m Garrison Hardie. Have a great day, and Lord bless.
Dr. Natasha Bagdasarian, Chief Medical Executive for the state of Michigan, shares what you need to know about the new omicron BA.5 subvariant, as well as the best practices for protecting against COVID-19 throughout this summer. GUEST: Dr. Natasha Bagdasarian, Chief Medical Executive for Michigan —— Looking for more conversations from Stateside? Right this way. If you like what you hear on the pod, consider supporting our work. Music in this episode is by Blue Dot Sessions. See omnystudio.com/listener for privacy information.
Biden meets the Butcher of Riyadh / French COVID-19 deaths pass 150,000 as Omicron BA.5 subvariant erupts across Europe / Sri Lankan protesters occupy official residences of president and prime minister
Amazon has taken bigger cuts of each transaction over the past seven years, and its artificially low prices contribute to inflation, says a Columbia law professor. Omicron BA.5 is spreading faster than previous COVID strains. How should you approach testing now, and what does a negative home result really mean? California will be the first state to make its own insulin, Gov. Newsom announced last week. It's an effort to lower the cost of care for state residents with diabetes. Twitter is threatening to sue Elon Musk after he pulled out of a $44 billion plan to buy the social media giant. Former Trump strategist Steve Bannon has finally agreed to testify before the January 6 Select Committee. Ella Fitzgerald's 1958 performance at the Hollywood Bowl is now released as an album. She was at the prime of her talent, says her former drummer Gregg Field.
In this episode of RANE's COVID-19 podcast, we discuss the rush to vaccinate toddlers, why our doctors are getting another booster shot, and when the updated vaccines with Omicron BA variants will be ready. SEPARATE THE SIGNAL FROM THE NOISE With a Daily or Weekly Risk Intelligence Brief from RANE. Our ongoing risk monitoring saves time and costs for your business. Learn more at ranenetwork.com.
1.上集才剛錄完FDA專家會議解說，沒想到美國時間6月30日FDA就已經正式公告，建議10月開打的加強針要包含針對BA.4/BA.5的成份。 https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-recommends-inclusion-omicron-ba45-component-covid-19-vaccine-booster 2.WHO和FDA的共識都是盡量增加抗體的廣度。而不是要猜中，針對哪個病毒株。因為下個病毒株實在難以預測。基本上都是選最不一樣的，希望增加廣度，但目前結論不同。這可能會讓藥廠無所適從。 3.FDA主要考慮的是BA.4/BA.5免疫逃逸最強，是目前最大的缺口。目前初步資料看來，BA.1產生的抗體不太能防BA.4/BA.5，但反過來就可以。 4.WHO則是覺得演化樹上BA.1離原始株離的很遠，用BA.1就可以接受了。 4.我的疑問是，需要規定每個公司都做一樣的事嗎？如果下一株新冠變種株難以預測，我們很難說到底是單價，雙價或是哪株Omicron會有最４好的效果。每個疫苗性質可能有所不同，像現在輝瑞似乎單價比雙價好，莫德納反之。Novavax則號稱原有疫苗對變種株效果還是有一定的效果。Sanofi和莫德納都有Beta次世代疫苗也可以引發很廣的抗體生成。每個疫苗公司不能有不一樣的研發方向嗎？我們需要把雞蛋放在同一個籃子裡嗎？ 另一方面，EMA和FDA 6月30日一起主持了一個次世代疫苗研討會，看來討論比較全面，參與者包含ICMRA（國際藥物法規主管機構聯盟）的18個會員國還有WHO。 Global regulators agree on key principles on adapting vaccines to tackle virus variants https://www.ema.europa.eu/en/news/global-regulators-agree-key-principles-adapting-vaccines-tackle-virus-variants 取得的共識： 1.目前疫苗不管是基礎劑或追加劑對防重症，住院和死亡都有保護力，鼓勵繼續使用。 2.新冠病毒持續演化，減少目前疫苗對感染和輕症的保護力。 3.雖然Omicron BA.4/BA.5在世界很多地方漸成主流，但之後新的變種株有可能很快就將它取代。 4.初步資料顯示mRNA疫苗加入Omicron株作為加強針，可以增加並延長保護的時間。雙價mRNA疫苗可能可以增加免疫的廣度。 5.這樣的疫苗應該一開始只用於加強針，是否能用於基礎劑型，要等待更多資料。 6.包含其他變種株的疫苗，比方說Beta變種株，也可能可以考慮作為加強針，如果臨床資料顯示其對於Omicron和其他變種株可以產生足夠的中和抗體。 7.有許多證據還在蒐集，參與者強調要小心的檢視不斷出來的新資料來決定每個新次世代疫苗的適用性。 8.法規單位強調新疫苗開打的話，要有事先計畫好的真實世界保護效益的研究，以便即時知道其對感染，住院和死亡的保護力。 更詳細的討論內容還有結論會在幾天內在 ICMRA網站公布。 歡迎追蹤前台大感染科醫師。04b的發聲管道！ 我的電子名片 https://lit.link/linshibi 希望大家當我的種子教師，推廣正確的新冠衛教。科學防疫，不要只以恐懼防疫！ 歡迎贊助林氏璧孔醫師喝咖啡，讓我可以在這個紛亂的時代，繼續分享知識努力做正確新冠相關衛教。 https://pay.firstory.me/user/linshibi Powered by Firstory Hosting
Photo: #Covid: The risks of Omicron BA.4/5. Dr Henry Miller, Pacific Research Institute, www.HenryMillerMD.org https://erictopol.substack.com/p/the-ba5-story?utm_medium=email
Who will pay for Biden's new "forever war" / Latest COVID-19 surge deepens across Europe and globally, fueled by Omicron BA.4 and BA.5 / "There was blood everywhere": Former Caterpillar worker speaks out on lack of safety
1.美國FDA在6月28日開會，決定秋天應該要打怎樣的加強針。主要投票決定的問題是，下一個加強針是否應該要包含針對Omicron變種株？經過一整天檢視莫德納，輝瑞，Novavax三家廠商現有次世代疫苗數據，疫苗效力回顧還有對未來的疫情預測，最後以19票贊成、2票反對，建議美國秋天施打的加強針要含有針對Omicron病毒株。 2.WHO也來報告6月17日對次世代疫苗做出的建議。 https://www.who.int/news/item/17-06-2022-interim-statement-on--the-composition-of-current-COVID-19-vaccines 這集主要是以STATnews這篇會議記錄和評論來和大家解說 FDA advisory panel recommends Omicron-containing booster shots https://www.statnews.com/2022/06/28/tracking-an-fda-advisory-panel-meeting-on-updating-covid-vaccines/ 04b解讀： 1.建議要包含Omicron這個建議本身沒什麼建設性，完全是預料中的，輝瑞莫德納根本已經跑在你法規單位決定前就做了呀。討論的重點不是要不要包括Omicron，應該是肯定要包括，真正重要的問題是，是BA.1就好了還是需要建議用BA.4/BA.5？還有，到底是單價還是雙價疫苗好？會議中沒有針對後面兩個問題投票，只是讓專家各自表達意見。 2.目前疫苗公司做出的資料都是BA.1，但BA.1已經幾乎結束他的流行。現在是BA.2的尾巴，還有各種Omicron的衍生株。專家普遍似乎比較偏向雙價疫苗，還有要針對BA.4/BA.5，目前流行株來做次世代疫苗。主要理由是，BA.4/BA.5是目前免疫逃逸最嚴重的變種。目前初步資料看來，BA.1產生的抗體不太能防BA.4/BA.5，但反過來就可以。因此，FDA後來在6月30日正式建議秋天的加強針要針對BA.4/BA.5做。 3.麻煩的是，這和WHO立場不同。疫苗公司要聽誰的....還有，美國預計10月開打，BA.4/BA.5應該已經燒完了。這有意義嗎？來得及嗎？這兩間公司連BA.1都做了七個月才做到現在的成果，很顯然不是原本輝瑞聲稱的100天。我估計次世代疫苗出來的時間有可能會延遲。量產可能要到11月才上軌道，其他國家要打到就更晚了。 4.另外Sanofi最近直接用Beta單價就做出不錯結果，莫德納也有Beta的資料，但會議上似乎完全沒有討論到。殊為可惜。 FDA 6月28日開會討論次世代疫苗 https://www.fda.gov/advisory-committees/advisory-committee-calendar/vaccines-and-related-biological-products-advisory-committee-june-28-2022-meeting-announcement 最後的投票問題： Does the committee recommend inclusion of a SARS-CoV-2 Omicron component for COVID-19 booster vaccines in the United States? 反面意見 FDA: Don't rush a move to change the Covid-19 vaccine composition https://www.statnews.com/2022/06/29/fda-dont-rush-to-change-covid-19-vaccine-composition/ 開會影片 https://youtu.be/BFdzNUus_CE 後續：6月30日FDA做出建議，次世代疫苗要針對BA.4/BA.5做 https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-recommends-inclusion-omicron-ba45-component-covid-19-vaccine-booster 歡迎追蹤前台大感染科醫師。04b的發聲管道！ 我的電子名片 https://lit.link/linshibi 希望大家當我的種子教師，推廣正確的新冠衛教。科學防疫，不要只以恐懼防疫！ 歡迎贊助林氏璧孔醫師喝咖啡，讓我可以在這個紛亂的時代，繼續分享知識努力做正確新冠相關衛教。 https://pay.firstory.me/user/linshibi Powered by Firstory Hosting
對BA.4、BA.5具良好抗體反應 莫德納盼新加強劑獲批准 https://udn.com/news/story/121707/6408784 莫德納（Moderna）22日表示其希望在秋季獲得批准的「二價新冠加強劑候選藥物」對快速傳播的 Omicron最新變體BA.4和BA.5展現出良好的中和抗體反應，且可能成為全球疫情的「轉折點」。 根據報導，與最初的疫苗相比，莫德納針對原始新冠病毒株和Omicron原始變種BA.1所開發的二價疫苗對上述兩者的表現更好。在臨床研究新結果中，該公司表示該加強劑對已逐漸成為全球主導的BA.4和BA.5也表現良好。 二價加強劑對於BA.4和BA.5的感染者，不論是之前曾感疫或從未感染者，引發高水平的感染阻斷抗體，然而即使是這些高水平仍是針對原始Omicron病毒株BA.1所達到的水平的三分之一，代表疫苗的效力仍有所減弱。莫德納執行長巴塞爾（Stephane Bancel）表示「我們將緊急向監管機構提交這些數據，並準備從8月開始供應我們的下一代二價加強劑」。 與目前的疫苗相比，莫德納的新疫苗是針對Omicron變種和武漢病毒株開發。莫德納首席醫療長波頓（Paul Burton）指出「我們認為這是種強大的抗體反應，病可能持續很長時間」。最新的研究發現與舊疫苗相比，新疫苗的加強劑增加了5.4倍的抗體。 莫德納總裁霍奇（Stephen Hoge）表示與公司現有疫苗相比，更高水平的保護證明改用新疫苗是合理的。波頓也補充說莫德納將在幾天內申請監管機構批准、其中包括英國。據悉，新的二價新冠病毒加強疫苗包含來自原始新冠病毒和Omicron病毒株。 莫德納新聞稿 https://investors.modernatx.com/news/news-details/2022/Moderna-Announces-Bivalent-Booster-mRNA-1273.214-Demonstrates-Potent-Neutralizing-Antibody-Response-Against-Omicron-Subvariants-BA.4-And-BA.5/default.aspx FDA 6月28日開會討論次世代疫苗 https://www.fda.gov/advisory-committees/advisory-committee-calendar/vaccines-and-related-biological-products-advisory-committee-june-28-2022-meeting-announcement 莫德納報告檔案 https://www.fda.gov/media/159492/download 歡迎追蹤前台大感染科醫師。04b的發聲管道！ 我的電子名片 https://lit.link/linshibi 希望大家當我的種子教師，推廣正確的新冠衛教。科學防疫，不要只以恐懼防疫！ 歡迎贊助林氏璧孔醫師喝咖啡，讓我可以在這個紛亂的時代，繼續分享知識努力做正確新冠相關衛教。 https://pay.firstory.me/user/linshibi Powered by Firstory Hosting
1.輝瑞終於在FDA開會前公布了次世代疫苗研究的初步成果。以針對Omicron變異株的單價疫苗30µg或是60µg做為第四劑，對BA.1的中和抗體可以增加13.5和19.6倍。如果是用雙價疫苗的話，則各自是9.1和10.9倍。 2.此臨床試驗包含1234位56歲以上受試者，分別施打不同的次世代疫苗，並和施打原始疫苗相比。單價Omicron疫苗30µg或是60µg相對於打原始疫苗的中和抗體倍數geometric mean ratios (GMRs)各自是2.23倍和3.15倍。雙價疫苗的兩個劑量則是1.56倍和1.97倍。 3.初步也有去做BA.4/BA.5的中和抗體，大概會比BA.1降三倍。這方面會繼續蒐集完整資料。 4.這些資料會送交FDA和EMA，各自在6月28日和6月30日開會要討論次世代疫苗，凝聚共識。 04b解讀： 1.提醒一下這僅是新聞稿。詳細資料還沒公佈。 2.美國FDA會在6月28日開會，決定到底秋天之前應該要打怎樣的加強針。主要會投票決定的問題是，下一個加強針是否應該要包含針對Omicron變種株？ 3.FDA已經釋出會前整理檔案，會議議程也公布，莫德納，輝瑞，Novavax，WHO，FDA都會報告。討論的重點可能不是要不要包括Omicron，應該是肯定要包括，但單價或雙價的問題就難決定了。 4.此外，其實BA.1也已經幾乎結束他的流行。目前是BA.2的尾巴，還有各種Omicron的衍生株。是否需要規定包含BA.2或是更新的變種？來得及嗎？相信會議上都會有所討論。 5.另外Sanofi最近直接用Beta單價就做出不錯結果，莫德納也有Beta的資料，應該也會討論到。 輝瑞新聞稿 https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-omicron-adapted-covid-19 FDA 6月28日開會討論次世代疫苗 https://www.fda.gov/advisory-committees/advisory-committee-calendar/vaccines-and-related-biological-products-advisory-committee-june-28-2022-meeting-announcement Topic: The committee will meet in open session to discuss whether and how the SARS-CoV-2 strain composition of COVID-19 vaccines should be modified Agenda https://www.fda.gov/media/159450/download 莫德納，輝瑞，Novavax，WHO，FDA都會報告 最後的投票問題： Does the committee recommend inclusion of a SARS-CoV-2 Omicron component for COVID-19 booster vaccines in the United States? YouTube直播 台北時間6月28日星期二8:30PM開始 https://youtu.be/BFdzNUus_CE 歡迎追蹤前台大感染科醫師。04b的發聲管道！ 我的電子名片 https://lit.link/linshibi 希望大家當我的種子教師，推廣正確的新冠衛教。科學防疫，不要只以恐懼防疫！ 歡迎贊助林氏璧孔醫師喝咖啡，讓我可以在這個紛亂的時代，繼續分享知識努力做正確新冠相關衛教。 https://pay.firstory.me/user/linshibi Powered by Firstory Hosting
The G7 war summit and the US abortion ban / Omicron BA.4 and BA.5 subvariants fuel yet another global surge of COVID-19 infections / 37 refugees dead, hundreds injured in Spanish-Moroccan police massacre at Melilla border
卡達發表的真實世界疫苗保護效益研究，探討疫苗施打劑數還有之前是否有自然感染過病毒，遇到Omicron BA.1或是BA.2時，對有症狀感染的保護力，還有對重症或死亡的保護力。在卡達施打BNT疫苗較多，莫德納次之。 Effects of Previous Infection and Vaccination on Symptomatic Omicron Infections https://www.nejm.org/doi/full/10.1056/NEJMoa2203965 結果顯示（這是取BNT疫苗的數字，莫德納也差不多，只是人數較少）： 1.僅自然感染過沒打過疫苗的，對Omicron BA1或BA2有症狀感染有50.8%保護力，對重症或死亡有71.6%保護力（但這裡人數少，信賴區間很大）。 2.打過兩劑沒自然感染過的，對有症狀感染無保護力，對重症死亡有73.5%保護力。 3.打過兩劑且自然感染過的，對有症狀感染有55.5%保護力，對重症死亡有94.3%保護力。 4.打過三劑疫苗但沒自然感染過的，對有症狀感染有54.0%保護力，對重症死亡有92.5%保護力。 5.打過三劑且自然感染過的，對有症狀感染有76.3%保護力，對對重症死亡有100%保護力。 這個研究證明，打疫苗加上自然感染這樣混合免疫（hybrid immunity）是有其一定效果的。 後半提到這個國內確診者的長期中和抗體追蹤研究。 無敵星星效力可維持100天！國內首份抗體研究出爐 400天後保護力下降 https://www.appledaily.com.tw/life/20220620/1A7419222DE91618E1FB497C56 羅一鈞說明，去年疾管署委託陽明交通大學團隊做確診者抗體追蹤的研究，希望針對疫情頭兩年、從前年1月到去年7月，通報確診的個案取得同意後，追蹤其1至2年內的抗體變化的情形做保護力的研究。成功取得236位確診者的同意進行長期的抗體追蹤，且需要定期抽血送至中研院等機構做抗體以及綜合抗體的檢驗，研究中以染疫後有無接種疫苗以及輕重症分成四組，當時疫苗主要是6月7月開始施打，針對有打疫苗的輕症跟重症患者，追蹤分別追蹤100天到150天，中和抗體幾乎沒有下降，表示保護效果維持不減，約在100%左右，代表確診加上有打疫苗的雙重保護效果。 換言之，Alpha病毒株感染的族群其保護效果可以維持100天以上，輕症、重症康復後，若沒施打疫苗，追蹤滿400天以上可發現，抗體濃度有明顯下降，但重症的抗體可以維持比較高比較久，輕症500天以上會掉到3成左右的保護效果，有施打疫苗比無施打疫苗在100多天的時候高。 歡迎追蹤前台大感染科醫師。04b的發聲管道！ 我的電子名片 https://lit.link/linshibi 希望大家當我的種子教師，推廣正確的新冠衛教。科學防疫，不要只以恐懼防疫！ 歡迎贊助林氏璧孔醫師喝咖啡，讓我可以在這個紛亂的時代，繼續分享知識努力做正確新冠相關衛教。 https://pay.firstory.me/user/linshibi Powered by Firstory Hosting
近來很多人擔心Omicron的表妹們。洪副院長昨天和我討論，說我擔不擔心邊境改為3+4，這些新的變種病毒會進來？ BA.4，BA.5，BA.2.12.1都出現了一陣子，至少兩個月，但不像一開始BA.1和BA.2一出現時就席捲全世界，而現在比較像是BA.2該感染的感染完一波了，所以這幾株才開始慢慢坐大。 這三株因為都有如同Delta變種株的L452位點上的突變，因此傳染力理論上更強，也有更嚴重的免疫逃逸。但目前至少可以說 沒有觀察到比較容易重症，底線是這個。 南非的BA.4，BA.5這波疫情已經結束了。他對於住院人數，加護病房住院人數，死亡人數造成的波動都很有限。 因此，雖有這些Omicron的相關變種株，你可以看到世界各國開放的腳步都沒有停下來。我個人是不會太過擔心。 真的敵人，下一株最重要的變種病毒，會被安上一個希臘字母的變種病毒，可能還沒出現。 不過他可能也差不多要出現了，因為兩年多來，大概半年左右就會出現一株。 老話一句，戒慎而不恐懼，讓我們繼續看下去吧。 入境首見BA.4、BA.5變異株 邊境攔截5例社區影響較小 https://www.cna.com.tw/news/ahel/202206130137.aspx 英國、美國相繼出現Omicron BA.4和BA.5等新亞型變種病毒的疫情。中央流行疫情指揮中心今天下午在疫情記者會中公布，台灣邊境首見Omicron新變種，1例BA.4、4例BA.5，分別為1女4男。 羅一鈞表示，今天公布的Omicron BA.4和BA.5等新亞型變種病毒染疫個案，年齡30多歲至60多歲，入境日介於今年6月2日至6月7日，其中BA.5個案2例來自美國，土耳其及波蘭各1例，BA.4是智利入境，皆為邊境攔截。 羅一鈞說明，國際上Omicron亞型變異株BA.4及BA.5分別於今年1月及2月首次於南非發現，研究顯示這二株病毒株均有傳染力較高及免疫逃脫特性，具社區傳播能力，4月至5月期間已於南非快速引發第5波疫情；WHO（世界衛生組織）於6月8日資料指出，目前已超過40個國家分別檢出BA.4及BA.5，且全球發現這二株變異株感染國家及病例數均持續增加。 此外，近期BA.5病毒株已造成歐洲地區葡萄牙疫情快速回升，且英國、法國近期疫情回溫，評估與BA.4及BA.5傳播有關；鄰近國家中紐西蘭、澳洲、新加坡、韓國及日本均有社區感染病例，香港近日發現有BA.4或BA.5境外移入個案，部分曾具社區活動史，可能造成社區傳播風險。 羅一鈞說，依現有研究，BA.4及BA.5致重症機率尚無明顯較高，但傳染力已提高，仍需嚴密監測，並提高疫苗接種率。 WHO 6月8日的整理 https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---8-june-2022 英國近來定序的變化 https://youtu.be/_bWjykVpF9A 歡迎追蹤前台大感染科醫師。04b的發聲管道！ 我的電子名片 https://lit.link/linshibi 希望大家當我的種子教師，推廣正確的新冠衛教。科學防疫，不要只以恐懼防疫！ 歡迎贊助林氏璧孔醫師喝咖啡，讓我可以在這個紛亂的時代，繼續分享知識努力做正確新冠相關衛教。 https://pay.firstory.me/user/linshibi Powered by Firstory Hosting
Brianne Barker, virologist and immunologist, associate professor of biology at Drew University, and co-host of the podcast This Week in Virology, explains what's known about newly discovered COVID variants and omicron sub-variants and puts data about vaccine effectiveness in context.
It's April 1st at The Late Show but the latest Covid strain isn't fooling around as over half the new cases in the U.S. were Omicron BA-2 last week, and the former president wants the world to know that he hit a ball into a hole. Meanwhile, Stephen learns that a "metal detectorist" came to the rescue of a botched beach proposal. Then, John C. Reilly returns to The Late Show to tease the handful of new movies he and Stephen filmed together in our beloved segment, "Maybe Coming Soon." Next, legendary documentarian Ken Burns & Tony Award winning actor Mandy Patinkin share a spot on the couch to talk about what it was like teaming up for their new film, "Benjamin Franklin," premiering Monday on PBS. Learn more about your ad choices. Visit megaphone.fm/adchoices
就在民眾為新冠病毒變異株Omicron即將離去而開心之時，就在各地取消口罩令之際，就在越來越多的美國人完成疫苗注射的大好形勢下，傳來了新的，傳染性更強的變異病毒BA.2。更多詳細文字和圖片内容請進入《今日話題》Facebook 臉書專頁：https://www.facebook.com/1300todaystopic/
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