Portable Practical Pediatrics

I'm thrilled to bring you a conversation with a visionary leader whose work is reshaping healthcare innovation—Vic Gatto. Vic is the driving force behind Elevate Health 2050, a bold initiative exploring the transformative potential of Web3, AI, and biotech to redefine healthcare's future, with a special focus on accessibility and impact—areas that touch the lives of women and children every day. Before this, Vic carved his path as the founder and Managing General Partner of Jumpstart Capital, where he's invested in over 200 early-stage healthcare startups, proving that innovation thrives beyond Silicon Valley's shadow, right here in Middle America. Vic's journey began with a Bachelor of Arts from Amherst College, giving him a broad foundation, followed by a Master of Business Administration from Vanderbilt University's Owen Graduate School of Management, equipping him with the strategic insight to navigate the complex world of venture capital. His entrepreneurial roots trace back to the 1990s, when he co-founded a software company in Boston, growing it from a small team to over 250 employees before selling it—a testament to his ability to build from the ground up. But Vic's story isn't just about credentials or exits; it's about a man who sees healthcare as a mission, not just a market. With Elevate Health 2050, he's pushing boundaries to ensure that the next generation—our women and children—benefits from cutting-edge solutions tailored to their needs. Today, we'll explore how his vision bridges technology and human health, and what it means for families everywhere. So, grab a cup of tea, settle in, and let's welcome Vic Gatto to the show. Enjoy, Dr. M

Itaconate, what is it and why does it matter? Science Heavy - skip to the bold for take home if you want to avoid the science. The biggest takeaway from this complex science is this: High fat, high sugar diets (Ultra Processed Foods) are associated with decreased itaconate activity and increased inflammation. The science further answers the question of whether we should allow ultra processed food in schools. Ultra Processed Foods likely reduce itaconate production driving inflammation, metabolic dysregulation, and gut dysbiosis, which could worsen active disease. Lower itaconate levels likely impair your body's ability to resolve inflammation, potentially leading to prolonged issues with healing and repair. To support itaconate's anti inflammatory activity, shift away from UPFs toward an anti-inflammatory diet (e.g., Mediterranean, rich in vegetables, omega-3s, and fiber) to reduce inflammation, support gut health, and enhance itaconate's immune-regulating effects. Science:..... Enjoy, Dr. M

Welcome to Dr. M's Women and Children First, where we dive into the latest insights on health and wellness for women and children. Today, we're honored to have Dr. Peter Rowe, a world-renowned expert from Johns Hopkins University, joining us to unravel the complexities of chronic fatigue.  Dr. Peter Rowe is a Professor of Pediatrics at the Johns Hopkins University School of Medicine. He is the inaugural Sunshine Natural Wellbeing Foundation Professor of Chronic Fatigue and Related Disorders and serves as the Director of the Chronic Fatigue Clinic at Johns Hopkins Children's Center. His areas of clinical expertise include chronic fatigue syndrome and other disorders characterized by fatigue and orthostatic intolerance. Dr. Rowe and his colleagues were the first to describe the relationship between chronic fatigue syndrome (CFS) and treatable orthostatic intolerance syndromes, as well as the association between Ehlers-Danlos syndrome and CFS. In this episode, Dr. Rowe and I dive deep into CFS and long Covid for both the parent and the clinician. We set the stage for a better understanding of this complex disorder in order to encourage earlier diagnosis and better therapy. From its impact on daily life to cutting-edge approaches for management, Dr. Rowe brings decades of expertise to help us understand this challenging condition.  Please Enjoy, Dr. M  

Let's dive into articles that have been critical to understanding type 2 diabetes and Insulin Resistance: the Ominous Octet and now the Egregious Eleven from the BMC Medicine paper and the 2009 Diabetes paper by Dr. Ralph DeFronzo. Peter Attia recently interviewed Dr. Defronzo and I am on listen #3 because it is so good and yet incredibly complicated. This piece is a compilation of that interview and reviewing Dr. DeFronzo's papers. “…all too often, the risk factors for these disorders are not addressed promptly in clinical practice, leading to irreversible pathologic progression… Traditional approaches to treatment involving sequential therapy, in which agents are added only after one has failed, contribute to clinical inertia and often prevent goal attainment, leading to adverse outcomes…. in turn contributing to increased morbidity and mortality. In contrast, early diagnosis and prompt, intensive intervention, often with initial combination therapy, leads to faster goal attainment and improved outcomes for at-risk patients.” (Handelsman et al. 2023)(Schwartz et. al. 2024) ...literature review. Enjoy, Dr. M

This is such an important topic to cover, even for a pediatrician. Dementia! This problem is slated to exponentially worsen in the coming decades. And it starts at birth! ​In the intricate landscape of Alzheimer's disease (AD), emerging research underscores a pivotal yet under explored facet for the why?, the brain's energy immunometabolism. A recent study by Patel et al., titled "Global Energy Metabolism Deficit in Alzheimer Disease Brain," delves into this domain, revealing significant metabolic disruptions that may illuminate novel upstream causes and possible therapies. ​ For the better part of the last few decades, all AD research centered on the amyloid and tau plaques as the causative problem. However, billions of dollars and many drugs later, this hypothesis has crashed and burned. Failed therapies coupled to the skyrocketing volume of AD patients in the US over the next few decades will burden the US healthcare system and families alike. Folks, we need better answers and therapies rapidly. Thus, I have been following this information on and off over the years looking for answers. Last month, Dr. David Perlmutter gave an excellent lecture on microglial cells in the brain and their impact on AD and neurocognition in general. One paper that he cited was the Patel paper. Let's look at it. Dr. M

Welcome to Dr. M's Women and Children First Podcast, where we explore groundbreaking approaches to health and wellness for women and children. Today, we're honored to introduce Dr. Kevin Boyd, DDS, MSc, a board-certified pediatric dentist and a trailblazer in the field of evolutionary oral medicine. With an illustrious career spanning over three decades, Dr. Boyd practices in Chicago and serves as an attending instructor at Lurie Children's Hospital's Pediatric Dentistry Residency Program, where he also consults for the Sleep Medicine service. Dr. Boyd's unique perspective is rooted in his undergraduate work in Biological Anthropology at Northeastern University as well as a Masters of science in Human Nutrition and Dietetics from Michigan State University. As a Visiting Scholar at the University of Pennsylvania's Museum of Anthropology, he conducts pioneering research into how dietary and lifestyle changes since the Industrial Revolution have impacted craniofacial and respiratory development. His work in Darwinian Dentistry draws on anthropological insights, examining prehistoric fossil records to understand modern systemic diseases, particularly those affecting airway health in children. A passionate advocate for early intervention, Dr. Boyd focuses on preventing and treating craniofacial-respiratory issues in young children, often under age 7, to promote healthy breathing, sleep, and neurocognitive development. Through his global lectures on early childhood malocclusion, pediatric sleep-breathing hygiene, and evolutionary oral medicine, Dr. Boyd is educating clinicians and parents alike. Join us as Dr. Boyd shares his anthropological insights, clinical expertise, and vision for revolutionizing airway health to help women and children thrive. Let's dive in! Dr. M

Picture this, a tiny, 30 nm, relentless RNA virus named norovirus slips into your life, uninvited, and turns your gut into a battlefield. It's not the flu. Forget that “stomach flu” misnomer. It's a Caliciviridae family member, a nonenveloped, single-stranded RNA ninja that thrives in making chaos. As a pediatrician, I've seen it wreak havoc in kids and parents alike, and it's a master of surprise. It just played Risk in my GI tract last week. Not Fun! Let's unpack how it infects, spreads, and toys with us humans, straight from the AAP's Red Book (2024) and other research. Norovirus causes an estimated 1 in 15 US residents to become ill each year as well as 71,000 hospitalizations and 800 deaths annually, predominantly among young children and the elderly. Norovirus doesn't knock, more so it sneaks in, needing under 100 viral particles to ignite trouble. You're sipping contaminated water, munching an oyster from a shady bay, or your toddler's unwashed hands after a playdate deliver the payload. It's mostly fecal-oral, stool to mouth via food, water, or surfaces. But don't sleep on aerosolized vomit. One hurl in a crowded daycare, and airborne particles linger, landing on toys, doorknobs, you name it for days. Did I say lingering! Smart viral spread! Gorilla warfare is on! Dr. M

What is measles - a refresher? Measles is a serious, highly contagious and potentially deadly viral infection. It is caused by an RNA paramyxovirus. It is spread by contact with droplets from an infected person's nose, mouth or throat. Sneezing and coughing can aerosolize the droplets and increase the range of infectious spread. Symptoms usually develop 8 to 10 days following exposure to an infected individual. A sick individual is contagious for 4 days before and 4 days after symptom onset. The reproductive rate is very high at 12+ meaning that 1 person will infect 12 and those 12 will get 12 more sick (144) and then 144 X 12 = 1728 X 12 = 20,736 and you are off to the exponential races....Plus, The Shock of a New Diagnosis: A Stoic Path Through the Storm. Enjoy, Dr. M

Today we are joined by a remarkable guest, Dr. Trenna Sutcliffe, a board-certified developmental-behavioral pediatrician and the founder of the Sutcliffe Clinic in the San Francisco Bay Area. Her educational history is impressive. She completed her undergraduate education in Molecular Biology and Medical Genetics followed by a masters degree in Biophysics at The University of Toronto. She obtained her Medical degree at McMaster University before her pediatric residency and training finished at the Hospital for Sick Children in Toronto. And oh by the way, she then did a year of pediatric Neurology residency and a Fellowship in Developmental Pediatrics. And finally, another Masters degree in Epidemiology at Stanford University. Thus, her educational path has allowed her to see the developmental landscape through a wider lens covering many disciplines. Dr. Sutcliffe started the first Developmental Pediatrics Clinic at Stanford and played the role of trailblazer throughout her career. With over 25 years of experience, Dr. Sutcliffe specializes in supporting children with autism, ADHD, and anxiety, offering a multidisciplinary approach to diagnosis and treatment. In this episode, she'll share her insights on the rising prevalence of these conditions, the importance of personalized care, and practical strategies for parents navigating developmental challenge. Fundamentally, Dr. Sutcliffe is a going to educate us on a better way to deliver whole person care to the developmentally challenged and beautiful children of this country. Two words encapsulate her work: empowering and thoughtful. Let's dive into this conversation with Dr. Sutcliffe to learn how we can help our children thrive! Dr. M

Literature Review 1) Microplastics in the Brain - From Science Advances: "Human health is being threatened by environmental microplastic (MP) pollution. MPs were detected in the bloodstream and multiple tissues of humans, disrupting the regular physiological processes of organs. Nanoscale plastics can breach the blood-brain barrier, leading to neurotoxic effects. How MPs cause brain functional irregularities remains unclear. This work uses high-depth imaging techniques to investigate the MPs within the brain in vivo. We show that circulating MPs are phagocytosed and lead these cells to obstruction in the capillaries of the brain cortex. These blockages as thrombus formation cause reduced blood flow and neurological abnormalities in mice. Our data reveal a mechanism by which MPs disrupt tissue function indirectly through regulation of cell obstruction and interference with local blood circulation, rather than direct tissue penetration. This revelation offers a lens through which to comprehend the toxicological implications of MPs that invade the bloodstream." (Huang et. al. 2025) This weeks podcast is a direct look at the world of toxicology and the human consequences of exposure over time. Microplastics are the new and next trouble maker on the planet. This study raises the concern that micro and nano plastics can and do enter the brain and will disrupt and thus alter brain physiological processes. More time to answer the true risk reality. Not good. and more....Plus a letter about MAHA from Dr. Jeffrey Bland, a serious take on preventative medicine as opposed to disease pharmaceutical centric medicine. Dr. M

Klotho Protein and Longevity I am reposting this information from last year because it is going to stay on my mind and I would like everyone to be aware of this peptide and the future of healing and what we can do now to be healthy. The science here is one part fascinating, one part complicated and equal parts necessary. Ok, it is time for a potential log step shift in the human understanding of neurological decline with age starting from birth. Enter the peptide, (C)Klotho, named after the greek goddess of fate who spins the thread of life for all. The Klotho protein was discovered by researchers looking at mice that aged faster than the general mouse population. These mice were noted to have a shortened lifespan, stunted growth, renal disease, blood vessel calcification, cardiac hypertrophy, hypertension, pulmonary disease, cognitive impairment, multi-organ atrophy and fibrosis. (Prud'homme et. al. 2022) When they looked closer, these mice were found to have hypoactive klotho proteins leading to an explosion of research over the past two decades to understand why. The next question was, could the hyperactive state provide an anti aging effect? To be clear the word anti aging should really say delayed inevitable aging. The answer was a resounding yes!..... Dr. M

Today we're tackling a topic that hits close to home for so many of us, sugar addiction and its impact on our kids and ourselves. We've got an incredible guest joining us: Michael Collins, the author of The Last Resort Sugar Detox Guide: Learn How To Quickly and Easily Detox from Sugar and Stop Cravings Completely. Michael is a former sugar addict who's been sugar-free for over 30 years, and he's helped thousands break free from sugar's grip through his work as the founder of SugarAddiction.com. He's also raised two children sugar-free from the womb to age six—a feat that's as inspiring as it is eye-opening. In this episode, Michael will share his journey, the science behind sugar's addictive pull, and practical strategies to detox for good, especially for families navigating the modern food landscape. Whether you're a parent worried about your child's sugar intake or someone struggling with cravings yourself, you won't want to miss this. Dr. M

Some Key Literature Review Studies from Year 14 This is a bit of a long newsletter. That is intentional. This will be a repository for some of the best research for us to look back on from time to time this coming year to solidify the learning moving forward. 1) Time restricted eating patterns are known to help physiology and metabolism by initiating a pause in the action of mTOR and muscle synthesis as well as inducing autophagy. Autophagy is critical to the clearance of broken or damaged cells following injury or disease.....Plus a to do list and recipe of the week. Dr. M

Welcome back to Women and Children First, where we dive into the science, policies, and practices that shape the health of our families and communities. Today, we are honored to have Dr. Tasha Stoiber, a leading scientist at the Environmental Working Group (EWG), whose work is at the forefront of protecting public health from environmental contaminants. Dr. Stoiber is a distinguished environmental scientist dedicated to understanding the impact of chemical exposures on public health. Dr. Stoiber earned her Ph.D. in Environmental Chemistry from the University of Wisconsin-Madison. She furthered her expertise through postdoctoral research in the ecotoxicology of nanoparticles in human tissues at the University of California, Davis. She brings a wealth of expertise to the conversation on how exposures to harmful substances, such as PFAS, heavy metals, and endocrine disruptors, can affect human health, especially in vulnerable populations like children and pregnant women. Currently, as a Senior Scientist at EWG, she focuses on researching contaminant chemicals in consumer products. At EWG, she plays a critical role in translating complex scientific research into actionable knowledge for consumers and policymakers. Her efforts help drive regulatory change and empower individuals to make safer choices for themselves and their families. Whether it's uncovering hidden contaminants in food, advocating for cleaner drinking water, or guiding parents on reducing toxic exposures, Dr. Stoiber's work is reshaping how we think about environmental health. Dr. Stoiber has contributed significantly to scientific literature, with publications addressing critical issues such as the presence of per- and polyfluoroalkyl substances (PFAS) in drinking water and freshwater fish. Her research has shed light on the widespread contamination of these "forever chemicals" and their potential health risks. Today, we'll explore the pressing issues surrounding chemical exposures, how they influence childhood development and long-term well-being, and, most importantly, what we can do to protect ourselves. Join me as we tap into Dr. Stoiber's deep knowledge and practical insights on creating a healthier world for the next generation. Dr. M

Here are 20 takeaways from year 14 of the SPA Newsletter 1) Diet significantly impacts respiratory health – Reducing processed foods and increasing anti-inflammatory nutrients can help manage asthma and allergies. 2) Consistent sleep routines improve cognitive function – Children who maintain a regular sleep schedule have better emotional regulation, learning capacity, and immune health. 3) Environmental toxins affect child development – Reducing exposure to air pollutants, pesticides, and household chemicals lowers the risk of chronic illnesses and delayed learning. 4) Chronic stress in children is rising – Teaching mindfulness, outdoor play, and limiting academic overburden will support mental well-being. Over stressing a child leads to little in the positive realm. Align their learning with their passions and watch them thrive. 5) Processed foods are linked to behavior issues among so many issues – High sugar and ultra-processed diets may contribute to ADHD-like symptoms and mood instability..... Dr. M

Today, I'm thrilled to repost the conversation with Ken Cook, President and Co-Founder of the Environmental Working Group, a powerhouse built to  protect human health and the planet. For over 30 years, he's been a leading voice challenging industrial agriculture, flawed U.S. food policies, and the toxic threats facing families—especially women and kids. From pushing the 1996 Food Quality Protection Act to shield children from pesticides to creating tools like the Skin Deep Database and Dirty Dozen list, Ken's work empowers moms with science to make safer choices. His latest venture is a podcast entitled Ken Cook Is Having Another Episode where he digs into endocrine disruptors and environmental health, issues hitting close to home for every parent. I hope that you enjoy my conversation with Ken Cook! Dr. M

Here is an article that I wrote for Rupa Fullscript in order to lay the ground work for effective preventative medicine. In order to get a longer runway to preventing disease, targeted lab screening is becoming very important. Classical medical training often relies on a traditional, binary approach to patient care: either a disease is present, or it is not. Functional medicine builds on this perspective by examining a continuum of potential dysfunction within lab results. Rather than waiting for a definitive diagnosis, functional medicine practitioners look for subtle “breadcrumbs” in the data—early indicators that might signal an evolving health issue long before it fully manifests. Routine lab panels remain a foundational tool, but their deeper insights are frequently underutilized. In functional medicine, we dig into each lab marker more thoroughly, considering it a potential clue to underlying imbalances, nutrient deficiencies, or early disease processes. This more granular interpretation goes beyond the standard understanding of “normal” values, seeking patterns that can inform more personalized and preventive care. By viewing “normal” lab ranges through a more nuanced lens, functional medicine aims to identify previously overlooked indicators. The ultimate goal is to narrow our concept of “optimal” health ranges, enabling a more attentive and individualized approach that supports the patient's best possible health outcomes.....plus a section on literature reviews. Dr. M

Welcome to Dr. M's Women and Children First, the podcast where we dive deep into the science of health, wellness, and prevention—especially for women, children, and families. Today, we have a truly special guest, Dr. Joe Pizzorno. Dr. Joe Pizzorno is a world-renowned leader in functional and naturopathic medicine, a trailblazer in environmental health, and the founding president of Bastyr University, one of the most prestigious natural health institutions in the world. With decades of research, policy advocacy, and clinical expertise under his belt, Dr. Pizzorno has been at the forefront of reshaping modern medicine by emphasizing the critical role of nutrition, detoxification, and whole person health in preventing and reversing disease. He is the author of these books: Textbook of Natural Medicine, The Toxic Solution, Clinical Environmental Medicine, Clinical Pathophysiology and Total Wellness. He is an incredible teacher and sought after speaker worldwide. Today, we'll be discussing metabolism and the hidden impact of environmental toxins on women and children's health, practical detox strategies, and how we can take charge of our well-being in an increasingly toxic world. If you're looking for science-backed insights and actionable tips to help your family thrive, you won't want to miss this conversation! I hope that you enjoy my conversation with Dr. Joe Pizzorno! Dr. M

This is a repost of the most listened to podcast with Richard J. Johnson, M.D.. Dr. Johnson is the Tomas Berl Professor of Medicine and the Chief of the Renal Division and Hypertension at the University of Colorado since 2008. A graduate of the University of Wisconsin, Madison, with a major in Anthropology, and a graduate of the University of Minnesota Medical School, Minneapolis, he is a physician and nephrologist whose research has focused on the role of sugar, and especially fructose, in driving obesity, diabetes, high blood pressure and kidney disease. Much of this work has explored the role of fructose metabolism, especially the generation of uric acid, in driving this phenotype, and his work has included studies ranging from molecular biology, integrative physiology, and evolutionary biology. He is the author of The Sugar Fix which introduced the first low fructose diet, and also The Fat Switch which explores the role of fructose in driving the obesity epidemic. His newest book, Nature Wants Us To Be Fat, is a tour de force of the entire pathway of survival via metabolic events in the body related to fructose and the polyol pathway. This is a must read book. This podcast will introduce you to the exceptional work of Dr. Johnson and how we are now mismatched metabolically for the environment of modern America and our food systems. Please enjoy this wide ranging conversation. Dr. M

"Life forms on our planet have evolved under the strong influence of a daily light/dark cycle. Sunlight being the primary source of energy for photosynthesis, the daily production of photosynthetic biomass has a predictable diurnal rhythm. The daily cyclical production of photosynthesized chemical energy is at the base of the food chain. Daily changes in light and darkness result in diurnal rhythms in other environmental parameters such as temperature and humidity. Such a predictable and robust daily rhythm in food availability and environmental factors has led to the evolution of a ~24 h internal timing mechanism or circadian rhythm to enable organisms to anticipate daily changes and to optimize fitness. Fundamental to this 24 h rhythms is the ability to acquire food when it is available and to store a portion of these resources for utilization during the rest of the day (i.e. the fasting period) without compromising fitness and vitality. The fasting period also serves as a time for standby and repair so that the organism is fit and competent to harvest energy when light (for photosynthetic organisms) or food becomes available. While many non-photosynthetic lifeforms with short lifespan (< a few days) may not derive profound benefit from a circadian timing system, they share fundamental biochemical mechanisms for acquiring and storing food when it is available and then utilizing this stored energy during a quiescent period of fasting for repair, stress resistance and vitality." (Longo et. al. 2016) This is the crux of the understanding that we, the homo sapiens on Earth, need to realize that biology trumps any desire that we may have to fight against it. We are and have been moving in the wrong direction for quite some time as it relates to what we were meant to do biologically as children and then adults. Not coordinating activity with the sun is a negative recipe for health. Third shift workers are the canary's in the coal mine for the risks of working and being awake when the sun is down and sleeping when it is up. This population has some very high risks for metabolic disease based on the data. (Biggi et. al. 2008) Plus a section on filaggrin genes and skin function. Dr. M

Over the next few weeks, I will be doing a deeper dive into the world of eczema or atopic dermatitis. In the greek language where we derive many of our medical terms, eczema is spelled ἔκζεμα or ékzema which means to bubble up. This weeks podcast guest is Dr. Ana Maria Temple, an expert in eczema. We go all over the place in the pod and it is so worth your time if your child suffers from eczema. Eczema is a multifactorial skin condition that affects millions worldwide, manifesting as red, itchy rash due to inflamed skin. Its prevalence has been steadily rising, particularly in industrialized nations, which suggests a complex interplay of genetics, environmental factors (epigenetics), and immune dysregulation. As we unpack the root causes of eczema over the coming weeks, an integrative functional medicine approach highlights not only the "what" but the "why" behind this condition—providing opportunities for both prevention and healthier management.....plus a section on Skin pH. Dr. M

Welcome back to Dr. M's Women and Children First Podcast, where we dive deep into the latest research and expert insights on health, nutrition, and optimizing well-being. Today, we sit down with an influential voice in prenatal and fertility nutrition, Lily Nichols, RD. Lily is a registered dietitian, researcher, and best-selling author known for her groundbreaking work on real food nutrition for pregnancy. Her previous books, Real Food for Pregnancy and Real Food for Gestational Diabetes, have redefined how we think about maternal nutrition, blending ancestral wisdom with cutting-edge science. Now, with her latest book, Real Food for Fertility, she expands her expertise to help couples optimize their chances of conception and support a healthy pregnancy from the very start. In this conversation, we'll explore the critical role of nutrient-dense, whole foods in fertility, how conventional dietary advice may be missing key elements, and why blood sugar balance, gut health, and micronutrient status are essential for reproductive success. Lily's research-driven approach challenges outdated dogma and offers practical, evidence-based solutions that can make a real impact on fertility outcomes. Whether you're planning for pregnancy, supporting a loved one on their journey, or simply interested in how diet shapes reproductive health, this episode is packed with actionable takeaways. Join me in welcoming Lily Nichols, RD, to the podcast! Dr. M Real Food for Fertility

Holidays and Connection The Christmas and winter holiday season is a unique time to sit back reflect on the past year. To behold the timeless beauty of life. The shared time offers us an opportunity to pause and connect with those who matter or should matter most in our lives. I love the bathroom plaque that says at the end of life it won't matter what you owned or what you knew, but rather the impact you had in a child's life. Fortunately, for us, the holidays bring a chance to foster authentic human connections. To actually sit in conspiracy together. These moments are more than just traditions, they are essential for our emotional, mental, and even physical health. In the hustle of modern existence, where schedules dominate and technology often mediates relationships, we are losing this skill set, especially for the younger generations, making it more important to stay focused now. Let us define human connection: Human connection is the act or feeling of being seen, heard, cared for and valued by another person or group. It is a most primary need for humans starting in infancy when a child needs a mother's touch and milk. It arises from the countless meaningful interactions that foster mutual understanding, trust, empathy, and shared emotional experiences that ultimately lead to a child's feeling of safety. The critical time period to establish attachment and connection is the first 2 to 3 years of life. Plus a section of literature review and a recipe of the week. Enjoy, Dr. M

Today, we have an extraordinary guest joining us—Dr. Francis Koster, a man who has spent decades uncovering the invisible forces that shape our environment and, ultimately, our health. Dr. Koster is the founder of Pollution Detectives, an initiative that combines data-driven science, community collaboration, and advocacy to address environmental issues that impact the air we breathe, the water we drink, and the ecosystems that support our lives. With a focus on actionable solutions, Dr. Koster empowers communities to identify and combat environmental risks, especially those affecting children, who are often the most vulnerable to pollutants. Through his tireless work, Dr. Koster has inspired countless individuals to take charge of their surroundings and has highlighted the profound connection between environmental stewardship and public health. Today, we'll dive into his groundbreaking efforts, the stories behind the data, and how we can all become part of the solution to ensure a healthier, safer future for the next generation. So, without further ado, let's welcome the innovative and inspiring Dr. Francis Koster to the show! Enjoy, Dr. M Pollution Detectives

Sulfurophane and health - It is clear now that SFN stands out as a powerhouse phytochemical with profound effects on human health through the pathway of nurclear factor erythroid related 2 (NRF2). It is found abundantly in cruciferous vegetables such as broccoli, broccolini, kale, and brussels sprouts. SFN is a bioactive compound with impressive clinical potential for preventing chronic disease and optimizing cellular health, especially in oxidant impaired/overloaded states. At its core, SFN is a sulfur-rich molecule derived from glucoraphanin, a glucosinolate precursor. The transformation occurs when the enzyme myrosinase, released during the chopping or chewing of cruciferous vegetables, catalyzes the reaction. Interestingly, this enzymatic activation can also be achieved via gut microbiota when raw vegetables are absent from the diet, emphasizing the remarkable adaptability of our biology to source essential nutrients as needed for survival. (Ali et. al. 2023) Nrf2 is a master regulator of cellular defense, orchestrating the production of detoxification enzymes, antioxidants, and other cytoprotective proteins. By activating Nrf2, sulforaphane enhances the body's resilience to oxidative stress, a key contributor to aging, inflammation, and the development of chronic diseases such as cardiovascular disease and diabetes. Studies reveal that sulforaphane also induces Phase II detoxification enzymes, such as glutathione S-transferase, which play a vital role in neutralizing and excreting harmful toxins.

Lymphatics - Refresher Lymphatics - a plumbing system that follows the circulatory system throughout the body including the brain where it is called the glymphatics. The function of these passively moving tubes is to transport fats around the body, clear cellular debris returning it to the liver and spleen, move fluid in and out of tissue to maintain fluid balance, transport and help immune cells function. By transporting fats , lymph is involved in vitamin movement to tissues and cells for Vitamins A, D, E, K. These are critical functions of metabolism, immunity and detoxification that when disrupted lead to chronic diseases of aging including edema, hypertension, autoimmunity and cardiovascular disease. "Traditionally considered a passive route for transport of fluid, immune cells, and lipoproteins, lymphatics are now known to be active players in major physiological and pathophysiological processes. Until recently, lymphatic vessel dysfunction was mainly associated with primary and secondary lymphedema. Unexpectedly, however, lymphatic vascular defects have been uncovered in conditions such as obesity, cardiovas- cular disease, inflammation, hypertension, atherosclerosis, Crohn's disease, glaucoma and various neurological disorders such as Alzheimer's disease." (Oliver et. al. 2021)...and a discussion on chemicals in school food. Enjoy, Dr. M

Vaccines In the coming months, I am going to take a deeper look at vaccines. I am fielding lots of questions in the office about the safety of vaccines. People are scared. Are they wrong? Should they be? Let me start here: first off, I am solidly pro vaccine. That is not the same as to be in agreement with the current vaccine schedule or that vaccines are without risk. I believe that the vaccine schedule and the risk should be questioned on a rolling basis in perpetuetum. This is the function of medical science. Question dogma always. Look for errors of past thinking and reassess on a continual basis. I think that on the face of it, the skepticism is well placed as the organizations tasked with our safety have made a mess of being honest during the COVID pandemic vaccine rollout..... plus a literature review. Dr. M

Dr. Ana-Maria Temple, MD, is an integrative pediatrician known for her whole child approach to children's health. She studied medicine at the University of North Carolina at Chapel Hill School of Medicine before pursuing pediatric residency training at Penn State Milton S. Hershey Medical Center. In 2017, Dr. Temple further specialized by completing a fellowship in Functional Medicine at the Cleveland Clinic Foundation. She combines conventional medicine with functional and lifestyle-based strategies to address common childhood conditions such as eczema, asthma, and allergies. Dr. Temple has a particular focus on helping families reduce dependence on medications by making sustainable health and wellness changes. With decades of clinical experience, Dr. Temple has been a vocal advocate for preventive care, emphasizing nutrition, environmental changes, and integrative treatments. She is the author of the two bestselling books Healthy Kids in an Unhealthy World and Ending the Eczema Epidemic. Additionally, Dr. Temple is a sought-after speaker and podcast guest, sharing her expertise on holistic pediatric care through various platforms. Today, we focus on her approach to eczema and children's health. Enjoy, Dr. M

Treatment - sometimes it is just better to watch and wait. Warts are a common ailment of childhood. Mostly a nuisance, sometimes a hindrance to function when located on the fingers and or areas of high use. There are two major types of wart type skin lesions - typical verrucous warts and molluscum contagiosum. Google has great molluscum and wart Images WARTS/MOLLUSCUM - To Treat Or Not To Treat? Common warts and molluscum contagiosum lesions are benign, but bothersome viral skin lesions that are common in children. We see them all the time in clinic. A common viral wart is caused by the human papillomavirus (HPV). HPV infects the epithelium of the skin, leading to keratinocyte proliferation in the skin's outer layer. This uncontrolled growth of the keratinocytes results in a thickened rough round lesion that we see. If the immune system fails to fully clear the virus, we see this lesion for months to years. Molluscum, caused by an unknown virus, follows a similar course with a dissimilar appearance. Neither molluscum nor warts have roots despite the myth propagated over the years. Molluscum lesions have a turbid white appearance under the umbilicated skin papule with the virus located within the upper skin layer. They are 1-4 mm in diameter. Viral warts are a little larger usually 3 -10 mm in size. They form a protective cap of dead skin (keratinocyte) cells and invade the deeper skin layer. The protective cap is rough like sand paper. Molluscum lesions peak around ages 2-7 years and for common warts the peak age is 7-15 years.... and more on a literature review. Dr. M

Megan Lyons, is a distinguished expert in personalized nutrition and wellness, with over a decade of experience in the field. As the founder of The Lyons' Share Wellness, she has dedicated more than 14,000 hours to one-on-one nutrition consulting, assisting clients with diverse goals such as weight loss, overcoming emotional eating, managing thyroid dysfunction, and reversing prediabetes and cholesterol issues. Her academic credentials are extensive: Doctorate of Clinical Nutrition from the University of Western States Master of Science in Holistic Nutrition from Hawthorn University Master of Business Administration from the Kellogg School of Management at Northwestern University Undergraduate degree from Harvard University Megan is double board-certified as a Clinical and Holistic Nutritionist, and she is a graduate of the Institute for Integrative Nutrition. In 2016, she authored the Amazon Top 10 bestseller, Start Here: 7 Easy, Diet-Free Steps to Achieve Your Ultimate Health and Happiness. Additionally, she hosts the popular podcast Wellness Your Way, where she shares actionable and motivational health information with thousands of listeners each week. Our goal today is to highlight the realities of women's health, hormones and breastfeeding. Enjoy, Dr. M The Lyons Share

Finding a relational balance with any person or persons can be a struggle if one side of the relationship dyad has a strong need for a gain to feel safe or whole. For example, a parent in a poor quality marriage or with significant childhood wounding may turn to the child for happiness and love when it is missing otherwise. A child in turn being young will often, out of filial love, try to meet the needs of the parent. These types of relationships can take on many forms and can become dysfunctional over time. I remember a parent child dyad from many years ago that was a budding enmeshed/codependent relationship between a mother and her son. Mom was absolutely unable to draw boundaries with her son as she felt all of his pain and reflected all of her childhood trauma onto the child's life with boundary-less smothering love and control. She simultaneously would restrict any behavior that she perceived as unsafe controlling his environment while drawing zero boundaries with regard to his behavior toward her and others within this controlled small world. He was a holy terror by 4 years of age. His mother was crying for help while being indignant that he was sweet and well meaning while she enabled every choice that he made. Her fear of drawing boundaries because of her own childhood restrictive parenting wounding left this child completely attached to her yet abusive because he felt completely out of control. The psychological pathology was exhausting for all in the room. Recommendations for therapy and interventions were met with scorn....plus a literature review. Enjoy, Dr. M

Today, we are honored to have Dr. E. John Wherry, a leading expert in the field of immunology, joining us. Dr. Wherry is the Chair of the Department of Systems Pharmacology and Translational Therapeutics at the University of Pennsylvania, where he also directs the Institute for Immunology. His undergraduate degree was obtained at Penn State University before completing his PhD in Immunology at the Thomas Jefferson University. A thought leader in T cell biology and immune memory, Dr. Wherry's work has been instrumental in improving therapies for viral infections, vaccines, and immunotherapy treatments. His discoveries in the field of immune exhaustion have had a profound impact on the way we approach treatments for cancer and autoimmune diseases. Widely published in top academic journals including Nature, Cell, and Science, Dr. Wherry is a heavy contributor to Covid research and especially the understandings of long Covid. Today, we discuss Covid and the current state of the science regarding vaccines, long covid and what we can do better next time there is a pandemic. Enjoy, Dr. M  

Review of Dr. Casey Means' Good Energy In her book, Good Energy, Dr. Casey Means explores the complex relationship between our metabolic health and the quality of energy we experience in daily life. Dr. Means is an ENT surgeon that graduated from Stanford University Medical School before eschewing it all to dive into the world of disease prevention. Drawing from her background in integrative medicine and her deep understanding of metabolic science, Dr. Means presents a compelling case for why energy levels are not merely a factor of rest and diet, but a direct reflection of how well our cells are functioning on a biochemical level. And this is the key, the understanding of the biochemistry of the why! In today's modern world, so many of us feel sluggish, fatigued, or burned out, and the causes are often elusive. We live in a time where external stressors, processed foods, environmental toxins, and sedentary lifestyles disrupt our body's ability to produce and regulate energy efficiently. Dr. Means calls for a paradigm shift in how we view energy: it's not just about getting more sleep or drinking another cup of coffee. It's about restoring the metabolic health of our cells to optimize the energy they generate.....plus a literature review and a recipe. Enjoy, Dr. M

Literature Review Week Why do some people react to mosquitoes so vigorously? There is fascinating data for me in the Nature article, as I see lots of kids that react strongly to mosquitoes while others do not at all. A hyper primed immune reaction makes a lot of sense as the immune system is extra sensitive to the insult in individuals that have chronic allergic phenotypes. They are in effect polarized to see the outside world through an irritant lens and thus react in a more robust way. The cell called GD3 releases Interleukin 3 or IL-3 which is a cytokine signaling molecule that tells skin based sensory neurons to become more sensitive to allergens like house dust mites, environmental molds, and in this case mosquito saliva. Thus, the mosquito saliva induces more of the itch scratch cycle. The effect is to increase the gain sensitivity on the skin to 10. This is likely a main reason why having an allergic child take immunotherapy against allergens that they react to lowers the rheostat for all irritants. It is like a global check on the sensory system. This is another reason to consider SLIT and or SCIT immunotherapy in allergic children... Plus a discussion on the Joe Rogan podcast with Callie and Casey Means. Enjoy, Dr. M  

  Obesity and Change - The Tech Intersection Welcome to the podcast! Today, I am thrilled to host Dr. Deborah Tate, a distinguished professor in the Department of Nutrition at the University of North Carolina in Chapel Hill, with joint appointments in Health Behavior and Nutrition. She also holds a faculty appointment at the Nutrition Research Institute in Kannapolis, North Carolina where she explores innovative approaches to improve lifestyle behaviors that impact obesity, diabetes, and chronic disease risk. Dr. Tate is a behavioral scientist, receiving her Ph.D. in Clinical Psychology at Virginia Tech. Her research focuses on two main areas: (a) strategies for improving both short and long-term body weight regulation to reduce disease risks and (b) the development and translation of programs as alternatives to clinic-based care using digital and wearable technologies. She is known internationally for her work has published many papers in major nutrition and medical journals. Her work spans the intersection of behavioral health and obesity whereby she is a pioneer in digital health interventions. Her work has been pivotal in developing digital tools and online programs that support sustainable health changes, making access to wellness resources more inclusive and effective. Dr. Tate has been at the forefront of harnessing technology to create lasting change, blending behavioral science with digital advancements to empower individuals and families to make improved choices. Her contributions have transformed how we think about health interventions in today's digital age, offering scalable solutions that reach beyond traditional boundaries. Get ready for an insightful conversation with Dr. Tate as we dive into the science and the potential of digital health to foster resilience and well-being. Enjoy, Dr. M

Section I Understanding the Action and Use of GLP-1 Agonists in Children – A Pediatrician's Viewpoint The United States, like much of the developed world, is facing increasing rates of childhood obesity and related health concerns. Despite years of research and various efforts, addressing this public health issue remains a complex challenge. This article reviews the potential mechanisms, benefits, and considerations for using GLP-1 agonists in children based on the current scientific understanding. While early research is promising, the application of these treatments in children requires careful consideration and should always be done in consultation with a healthcare provider. As a pediatrician, I recognize that while the science behind these treatments is evolving, it's important to remember that individual responses to treatments can vary. For children, every approach needs to be carefully weighed, considering their unique developmental needs..... Enjoy, Dr. M

Section I Are Smart Phones a benefit or a curse for the teenager in school? This is becoming a huge topic this past year or so. Logic would seem to dictate that this is a curse more than a benefit, but what does the data and expert opinion show? The Scientific American article "Do Phone Bans Help Students Perform Better in School?" examines the growing trend of banning smartphones in schools to enhance student performance and well-being. Numerous U.S. cities, including New York and Los Angeles, have recently implemented or are considering bans on phones in classrooms. Schools use tools like the Yondr pouch, which locks phones away during school hours, to enforce these bans. These measures are popular with educators and parents, with 60% of likely voters in New York State supporting such restrictions. Charlotte Schools has this policy: "In accordance with Charlotte-Mecklenburg Schools Student Code of Conduct, personal technology devices, including cell phones must remain off and put away during school hours. Violations will result in confiscation of the personal technology device. The district is not responsible (monetary value or replacement) for theft, loss or damage to personal technology or other electronic devices brought onto CMS property." (CMS) My informal poll has a higher number of parents interested in phone ban restrictions in North Carolina....plus a section on teen anxiety. Enjoy, Dr. M

Welcome to the podcast! Today, I am thrilled to have a true pioneer in the field of metabolic health, Dr. Robert Lustig, MD, joining us. Dr. Lustig is a neuroendocrinologist and Professor Emeritus of Pediatrics in the Division of Endocrinology at the University of California, San Francisco. He is best known for his groundbreaking work on the intersection of diet, obesity, and metabolic disease, particularly his deep dive into the role of sugar as a driving force behind many of today's chronic health issues. As the author of several influential books, including Fat Chance, The Hacking of the American Mind and Metabolical, Dr. Lustig has been a vocal advocate for public health, helping to raise awareness about the harmful effects of processed foods, particularly refined sugars. His research has been instrumental in shifting the conversation around nutrition, focusing on the biological impacts of sugar and the ways it contributes to insulin resistance, obesity, and metabolic syndrome. His most recent paper entitled Obesogens, A Unifying Theory for the Global Rise in Obesity in the International Journal of Obesity - Nature is a ground stirring take on the current research. We are excited to explore his latest insights into metabolic health and the science of obesity, and how we can apply this knowledge to improve our own well-being. Let's welcome Dr. Lustig to the show! Dr. M

Upcoming Podcast and Current Book Review. For all parents who love the content of this newsletter, I have a book for you to enjoy. It is a comprehensive look at parenting a child in modern times through the struggles of food, technology, stress and life in general. My good friend Elisa Song is a Stanford, NYU and UCSF trained pediatrician and lover of children. In her recently published book, Healthy Kids, Happy Kids, she offers a comprehensive and integrative approach to pediatric health that will resonate deeply with today's parents who seek to navigate the complexities of modern healthcare and modern life. Dr. Song's dual expertise as a pediatrician and a mother is evident in her compassionate and practical guidance. Much like the work of our mentor Sandy Newmark, her book is relatable but more importantly scientifically grounded. At the heart of Dr. Song's philosophy is the idea that optimal health for children is not just the absence of disease but a state of overall well-being or optimal health, including: physical, emotional, and mental states. She emphasizes the importance of nutrition, advocating for whole, unprocessed foods while addressing the impacts of common allergens/intolerances, sugar, and artificial additives on children's health. Her dietary recommendations are backed by a solid understanding of how nutrition influences immunity, inflammation, behavior, long-term development and ultimately chronic disease. Plus, a discussion on cancer, autoimmunity in children post Covid... Enjoy, Dr. M

Section I Literature Review 1) Long Covid in children - the symptoms are getting more clarity in who has what . From JAMA: 898 school-age children (751 with previous SARS-CoV-2 infection and 147 without) and 4469 adolescents (3109 infected and 1360 uninfected) were included in the analysis. The time between infection and symptom analysis was 1.5 years. In models adjusted for sex and race and ethnicity, 14 symptoms in both school-age children and adolescents were more common in those with SARS-CoV-2 infection history compared with those without infection history, with 4 additional symptoms in school-age children only and 3 in adolescents only. These symptoms affected almost every organ system. The cumulative data shows us that neurocognitive (Headache, attention concerns, sleep dysregulation), pain, and gastrointestinal symptoms in school-age children were common, but changed to loss of smell and/or taste, body aches and pain, focus struggles and fatigue related symptoms in adolescents. (Gross et. al. 2024) Age has a huge effect on these outcomes as the older population has more frequent and problematical disease findings. Mood disorder is highly associated with worsened findings. I suspect from the historical data set over the last four years that children with chronic mental stress, poor quality diets, sleep issues, and poor activity levels at baseline have worsened acute and long term prognosis. Plus a section on a book review for Change Your Genes, Change Your Life. Enjoy, Dr. M

Children are and always will be a marker of a society's quality and focus on their health. When we look at the landscape of childhood health trajectories, we see a declination in quality and an inclination toward diseases of immune dysregulation and underlying chronic unchecked inflammation. What is the genesis point, or where is ground zero? For me, that answer is the newly understood ecosystem called the intestinal infantile microbiome. What is the Intestinal Microbiome? The intestinal microbiome is a complex and dynamic community of microorganisms that plays a crucial role in all mammalian health, particularly in the early stages of life. The development of the human infant intestinal microbiome has profound implications for the child's immune system, tolerance to the outside world, metabolism, and health trajectory. Understanding the factors that influence the establishment and evolution of this microbiome can help in devising strategies to promote optimal health from infancy through adulthood. This article dives deep into the key aspects of the development of the infant intestinal microbiome, highlighting the critical stages, influencing factors, and long-term health implications. How Do Infants Establish Their Gut Microbiome?.....

David L. Katz, MD, MPH is a specialist in Preventive Medicine and Lifestyle Medicine, with particular expertise in nutrition. He earned his BA at Dartmouth College (1984); his MD at the Albert Einstein College of Medicine (1988); and his MPH from the Yale University School of Public Health (1993). He completed sequential residency training and board certification in Internal Medicine (1991) and Preventive Medicine/Public Health (1993). Katz is the founder and former director of Yale University's Yale-Griffin Prevention Research Center (1998-2019); Past President of the American College of Lifestyle Medicine; President and Founder of the non-profit True Health Initiative; and Founder and CEO of Diet ID, Inc. The recipient of numerous awards for teaching, writing, and contributions to public health, Katz was a 2019 James Beard Foundation Award nominee in health journalism, has been a widely supported nominee for the position of U.S. Surgeon General, and has received three honorary doctorates. Katz has served as a nutrition columnist for O, the Oprah Magazine; an on-air contributor for ABC News/Good Morning America, and with appearances on most major news programs and contributions to most major magazines and leading newspapers, including OpEds in the New York Times and Wall Street Journal. His most recent book, How to Eat, co-authored with Mark Bittman, is a 2021 IACP Awards finalist and is worth your time. I have had the pleasure of hearing him speak many times over the years and he is an amazing orator and I am blessed to have this hour with him. Today, we dive into the science of childhood obesity and what are the public health pain points that can be pressed on to change the negative trajectory. Enjoy, Dr. M

Literature Review 1) Does oral health affect your life if you are sick and in intensive care? According to a new study in JAMA, the answer is yes. From the study: 10,742 patients - "toothbrushing was associated with significantly lower risk for Hospital Acquired Pneumonia and ICU mortality. Reduction in pneumonia incidence was significant for patients receiving invasive mechanical ventilation but not for patients who were not receiving invasive mechanical ventilation. Toothbrushing for patients in the ICU was associated with fewer days of mechanical ventilation and a shorter ICU length of stay. Brushing twice a day vs more frequent intervals was associated with similar effect estimates....Non-ICU hospital length of stay and use of antibiotics were not associated with toothbrushing." (Ehrenzeller et. al. 2024) Why does this matter? In effect, what this study shows is that patients with oral hygiene needs that are not met will have increased bacterial burdens leading to infectious disease risk via systemic inflammation and possibly bacterial translocation. At the end of the day, oral hygiene is very important to lower the total burden of inflammation in everyone, but especially in the most ill patient. It is super important for everyone to brush 2-3 x daily and floss daily at night..... Plus a discussion on Back to School. Enjoy, Dr. M

This week I sit down with Dr. Elisa Song to discuss her new book, Healthy Kids, Happy Kids. Dr. Song is a graduate of Stanford University with a degree in political Science. She then attended New York University for her medical degree and finally a stop at the University of California San Francisco for pediatric residency training. In her own words, Dr. Song is a holistic pediatrician. She founded Whole Family Wellness, an integrative pediatric practice in Belmont, CA – one of the first and most highly regarded holistic pediatric practices in the country. She created Healthy Kids Happy Kids – dedicated to empowering parents to take charge of their kids' health … naturally! She lectures around the world for the Center for Education and Development in Clinical Homeopathy (CEDH), Academy for Pain Research, Institute for Functional Medicine, and Holistic Pediatric Association, A4M among others. In this interview we look at health through a prevention first lens with a deep look at the intestinal microbiome and nutrition. Dr. Song's immense fund of knowledge is on full display in her book and this interview. Please enjoy my conversation with Dr. Elisa Song, Dr. M

Sleep Part IV Continuing the sleep education from a few weeks ago. Sleep is a most special event that we all need to continue to focus heavily on in order to live a healthy and long life. It may be the single most important event that we do daily. Here are a few more quick hits on sleep from the Matthew Walker's Book and other publications. 1) Aim for a minimum of 7 hours nightly to maintain adequate memory consolidation, immune health and emotional regulation. Young children and teens need 8-14 hours depending on age. 2) Do not eat close to bedtime. Stop eating three hours before you plan to go to sleep. Avoid rapidly digesting refined carbohydrates as they turn into energy quickly raising core temperature which makes it harder to fall asleep as we need our body temperature to drop 3 to 4 degrees F at night to fall asleep. Heavy protein meals at night are not a great idea. Eat the heavier proteins early (before 6 pm) if at all in the evening....plus a section on summer Covid surge. Enjoy, Dr. M

Sleep Part III Finally, the other elephant in the room related to sleep is STRESS. Stress alters the function of the hormone cortisol and can significantly alter night sleep function. There are three major chemicals that affect sleep: cortisol, adenosine and melatonin. In normal conditions, adenosine rises during the day making you sleepy, cortisol hits its low point at night and melatonin rises as the sun goes down. This combination puts pressure on you to feel sleepy and want to go to bed. Unfortunately, modern life has made many of us feel stressed and sympathetically fired up which affects cortisol function. Instead of being at its nadir at night, the stress response causes cortisol to rise at inappropriate times disrupting sleep onset and maintenance. Couple this stress with facebook addiction and screen induced melatonin suppression and you have a recipe for insomnia and disrupted sleep. (Hanson et. al. 2010)....Plus, a section on cellphones and driver knowledge. Enjoy, Dr. M

This weeks guest is Dr. Colleen Cutcliffe. Dr. Colleen Cutcliffe is a researcher and a thinker with persistence. Throughout history, these are the human qualities that lead people to develop amazing products and lead projects for the world to benefit from. Her story is one of discovery, passion and caring. Dr. Cutcliffe holds a Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and a B.A. in Biochemistry from Wellesley College. Her scientific background is complemented by her experience in managing both research and operations teams in the biotech sector. Before founding Pendulum Therapeutics, she held senior positions at Pacific Biosciences and Elan Pharmaceuticals, where she was instrumental in developing various technological platforms. She is the co-founder and CEO of Pendulum Therapeutics, a biotechnology company focused on developing innovative solutions to improve gut health through microbiome-based interventions. With over 20 years of experience in the biotechnology industry, Dr. Cutcliffe has become a recognized leader in microbiome science, applying her expertise to bridge the gap between cutting-edge research and practical, consumer-facing health solutions. At Pendulum Therapeutics, Dr. Cutcliffe has led the development of novel probiotic formulations specifically designed to address metabolic diseases like type 2 diabetes. Her work has been pivotal in the growing recognition of the microbiome's role in human health, pushing forward the concept of targeted probiotics as a potential therapeutic option. Under her leadership, Pendulum Therapeutics has gained recognition for its scientific rigor and innovative approaches to personalized nutrition. Today, we discuss the story of her discovery and the fact that her work is the beginning of a hopeful wave of change for humans through gut microbiome manipulation. Dr. Cutcliffe helps us understand the basics of the microbiome, what helps it stay balanced and conversely, what upsets it. How does it support our metabolism and health in general. The main thrust of her work comes into the spotlight with Akkermansia mucinophilia, a keystone species for positive health. Please Enjoy my conversation with Dr. Cutcliffe, Dr. M

Epigenetics and Pregnancy Epigenetics is the study of environmental signals and their effects on our genes. Our genes are not altered so much as they are read and used differently based on the environmental inputs. Epigenetic effects are critical during the pregnancy period as the environmental signals can alter an offspring's outcome both in good and bad ways. Making sure that we control for better environmental signal exposure while pregnant can go a long way to protecting our children's DNA from dysfunction and thus their outcome with health. It is well known that chemicals are generally negative insults to our epigenome while anti-inflammatory whole foods are positive. These epigenetic marks can be conserved over multiple generations making them extraordinarily beneficial or dangerous. Here we will discuss the lifestyle mitigating factors for a positive pregnancy and newborn outcome....plus an ode to Brenda Wassum. Dr. M

Sleep Part II Let us pause here! So far we now know that humans at all ages will suffer from memory dysfunction and brain sewage cleanup problems leading to inflammation and damage long term. What ages are most at risk? They are likely mirrored by other physiologic events that are at risk based on age. Teenagers, infants and toddlers are rapidly growing creatures requiring more macro/micronutrients, water, and toxin avoidance for success. It is likely that sleep follows these same principles. Going to a simple google scholar search for "sleep deprivation age risk" brings up countless articles on the effects of sleep deprivation in mothers and children on risk of obesity, diabetes, premature birth and much more. ....Plus more on gender and emotion as well as a recipe of the week. Enjoy, Dr. M

Kenneth R. Pelletier, MD, PhD is a Clinical Professor of Medicine, Department of Medicine; Department of Family and Community Medicine, and Department of Psychiatry at the University of California School of Medicine (UCSF) in San Francisco. He is Director of the Corporate Health Improvement Program (CHIP) which is a collaborative research program between CHIP and 15 of the Fortune 500 corporations including Ford, Oracle, Prudential, Apple, Dow, Lockheed Martin, Pepsico, IBM, American Airlines and NASA. Dr. Pelletier served as Clinical Professor of Medicine at the University of Arizona School of Medicine and Stanford University School of Medicine. He was a Woodrow Wilson Fellow, studied at the CG Jung Institute in Zurich, Switzerland and has published over 300 professional journal articles in behavioral medicine, disease management, worksite interventions, alternative/integrative medicine, and epigenetics. At the present time, Dr. Pelletier is a medical and business consultant to the US Department of Health and Human Services, the World Health Organization (WHO), the National Business Group on Health, the Federation of State Medical Boards, and major corporations including Cisco, IBM, American Airlines, Prudential, Dow, Disney, Ford, Mercer, Merck, Pepsico, Ford, Pfizer, Walgreens, NASA, Microsoft ENCARTA, Blue Cross/Blue Shield, United Healthcare, Health Net, the Pasteur Institute of Lille, the Alpha Group of Mexico, and the Singapore Ministry of Health. Dr. Pelletier is the author of fifteen (15) major books, including the international bestseller Mind as Healer, Mind as Slayer and Change Your Genes – Change Your Life: Creating Optimal Health with the New Science of Epigenetics. Today we enjoy the amazing viewpoint that Dr. Pelletier has for humanity. We have control over our destinies individually and collectively. This conversation is the culmination of years of incredible study. Enjoy, Dr. M  

Sleep Update for 2024 Sleep has always been a necessary function of everyday life for all mammals. From an evolutionary perspective this cannot be a mistake as during the period of sleep you are vulnerable to predation. Therefore, there has to be a really good reason for mammals to sleep for extended hours. What is that reason? Why are toddlers and frankly all of us more cranky when we do not sleep enough? Why are our genes tied so tightly to circadian rhythms? Why are people so metabolically unwell when they are sleep deprived? ...plus updates on heat exhaustion and covid. Enjoy, Dr. M