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Cancer is among the most common and feared diseases in the modern world. Dr. Selwyn Vickers—president and CEO of Memorial Sloan Kettering Cancer Center—joins host Mark Labberton to discuss how precision oncology, data, and faith are transforming cancer treatment. A distinguished cancer surgeon and pancreatic cancer researcher, Vickers explains how groundbreaking advances in genomics, immunotherapy, and AI are transforming once-lethal diagnoses into survivable and even chronic conditions. Together, they explore not only the cutting-edge science of cancer care but also the spiritual, emotional, and social dimensions that affect every patient and caregiver. Resonating with themes of suffering, hope, and resurrection, this conversation offers clarity, compassion, and courage for all who are affected by cancer—from those newly diagnosed, to medical professionals, to grieving families and curious listeners. Episode Highlights “We're getting to a point where we will, in the next five to seven years, have a much better chance to cure people—and to make pancreatic cancer a chronic illness.” “We are in what's somewhat coined the golden age of cancer research.” “Cancer is a disease that creates an existential threat in ways no other illness does.” “If a tumour forms, it means your body's immune system has made a social contract with the cancer.” “We changed the diagnosis in 10–12 percent of the patients who come to us—sometimes from cancer to no cancer.” “Cancer care is a team sport. And our patients often inspire us more than we help them.” Helpful Links & Resources Memorial Sloan Kettering Cancer Center BioNTech – creators of mRNA vaccines for COVID and cancer CAR T-Cell Therapy Overview (Cancer.gov) Tim Keller on cancer and hope Emma Thompson's Wit (HBO) BRCA1 and BRCA2 Genes and Cancer Risk MSK-IMPACT: Next-Gen Tumor Profiling About Selwyn Vickers Selwyn M. Vickers, MD, FACS, is the president and CEO of Memorial Sloan Kettering Cancer Center (MSK) and the incumbent of the Douglas A. Warner III Chair. He assumed the role on September 19, 2022. Vickers is an internationally recognized pancreatic cancer surgeon, pancreatic cancer researcher, and pioneer in health disparities research. He is a member of the National Academy of Medicine and the Johns Hopkins Society of Scholars. He has served on the Johns Hopkins School of Medicine Board of Trustees and the Johns Hopkins University Board of Trustees. Additionally, he has served as president of the Society for Surgery of the Alimentary Tract and the Southern Surgical Association. Vickers is the immediate past president of the American Surgical Association. He also continues to see patients. In 1994, he joined the faculty of the University of Alabama at Birmingham (UAB) as an assistant professor in the Department of Surgery, where he was later appointed to professor and the John H. Blue Chair of General Surgery. In 2006, Vickers left UAB to become the Jay Phillips Professor and Chair of the Department of Surgery at the University of Minnesota Medical School. Born in Demopolis, Alabama, Vickers grew up in Tuscaloosa and Huntsville. He earned baccalaureate and medical degrees and completed his surgical training (including a chief residency and surgical oncology fellowship) at the Johns Hopkins University. Vickers completed two postgraduate research fellowships with the National Institutes of Health and international surgical training at John Radcliffe Hospital of Oxford University, England. Vickers and his wife, Janice, who is also from Alabama, have been married since 1988. They have four children. Show Notes The ongoing threat and fear of cancer How Selwyn Vickers got into medicine Pancreatic cancer: Vickers's expertise “We are in what's somewhat coined the golden age of cancer research.” Sequencing the human genome “Is there a drug that might target the mutation that ended up creating your cancer?” Cancer as both a medical and existential diagnosis The revolution of precision oncology through human genome sequencing ”It takes a billion cells to have a one centimetre tumor.” Immunotherapy: checkpoint inhibition, CAR T-cell therapy, and vaccines Cellular therapy: ”Taking a set of their normal cells and re-engineering them to actually go back and target and attack their tumors. … We've seen patients who had initially a 30 percent chance of survival converted to an 80 percent chance of survival.” “We know in many tumours there's something called minimal residual disease.” “Immunizing yourself against cancer is a significant future opportunity.” Managing the power of data with AI and computational oncology Cancer-care data explosion: the role of computational oncologists Cancer vaccines: breakthrough mRNA treatment for pancreatic cancer ”Didn't ultimately win. We had to suffer through her losing her life, but was so appreciative that she got much more than the six months she was promised.” Tumour misdiagnoses and the importance of specialized expertise Pancreatic cancer challenges: immune cloaking and late-stage detection In the past, one in four would die from the operation for removing pancreatic cancer Long-term survival Future of cancer detection: AI-based medical record analysis and blood biopsies More accurate blood tests to confirm conditions Using AI to select those who are high-risk for cancer Pastor Tim Keller died of pancreatic cancer. In the past, “your doctor … helped you learn how to die.” ”[God's] given man the privilege to discover those things that have been hidden. And over time we've gradually uncovered huge opportunities to impact people's lives.” The state of breast cancer research and treatment “If you get the diagnosis of breast cancer, you have a 90 percent chance to survive and beat it over a five-year period of time.” ”In general, we're in a great state of understanding how to treat breast cancer, how to detect it early, and then have selective and targeted mechanisms to prevent it from coming back.” Prostate cancer research and treatment Theranostics: using a specific antibody to target cancer cells specifically Pediatric cancer: ”We actually treat more children for cancer than any hospital in America now, but in general, the survival for pediatric cancers is greater than 80 percent.” Emotional, psychological, and spiritual toll of cancer: importance of psycho-oncology How Sloan Kettering developed psycho-oncology to help cancer patients with mental and spiritual health Personal story: how a cafeteria worker empowers patients through food choices “We give back to them the right to choose what they get to have on their tray.” Cancer treatment is a team sport. Wit (film, Broadway play)—actress Emma Thompson plays a cancer patient studying the work of John Donne on death Socioeconomic and racial disparities in cancer care outcomes The healing role of community, support teams, and compassionate listening The importance of listening to cancer patients who are preparing to die The spiritual courage of patients and the transformative power of faith “Our patients often help us. We see the grace with which they often handle that journey.” The inspiration behind becoming a doctor: family legacy and human impact Terminal care: the sacred responsibility of walking with patients to the end Cancer research and treatment as a Christian vocation and expression of humanity Production Credits
This important piece shines a light on the evolution and challenges of Enhanced Recovery After Surgery (ERAS). If you've never listened to TopMedTalk, this is a great place to start. If you've listened before it's possible you've heard us talking with excitement about today's guest, we hope you find this session to be worth the wait. Hear how our guest's insights on the need for an understanding of the pathophysiological basis and integrated pre-, intra- and post-operative care for the best patient centered outcomes. We cover the concept of “DReaMing” (Drinking, Eating, Mobilizing) as both a goal and measure of recovery; it simplifies complex pathways, encouraging a focus on practical, patient-centered outcomes while reminding us to investigate barriers when these aren't achieved. Also, listen to our timely discussion regarding the misinterpretation of fluid management—shifting from avoiding overload to outright restriction—reiterating the importance of precision and nuance in applying guidelines. Can these approaches then be turned into individualized risk assessments, which bridge the gap between protocolization and personalization? Finally there's a powerful call for increased post-discharge research, to monitor and mitigate challenges like fatigue and pain. Recovery does not stop at hospital discharge. Presented by Desiree Chappell, Mike Grocott and Monty Mythen with their guest, Henrik Kehlet, Professor of Surgery at Copenhagen University and Professor of Perioperative Therapy at Rigshospitalet, Copenhagen University, Denmark. He is also an Honorary Fellow of the Royal College of Anaesthetists, UK, the American College of Surgeons, the American Surgical Association, the German Surgical Society, the German Anaesthesiological Society and American Society of Anesthesiology. Professor Kehlet has published more than 1,250 scientific articles and has given more than 300 invited lectures at international scientific meetings, several honorary lectures including the ASA Excellence in Research Award 2014. He was the first recipient of the BJS Society Award 2023. Like this? Want more? https://topmedtalk.libsyn.com/topmedtalk-henrik-kehlet-and-nick-scott-0 https://topmedtalk.libsyn.com/asa-2018-san-francisco-exclusive-professor-henrik-kehlet
En este episodio tenemos como expositor desde Chile al Dr Attila Csendes, especialista en Cirugía General y Cirugía Digestiva, como probablemente muchos saben el Dr Csendes es un padre de la cirugía, no solo Chilena sino Latinoamericana por sus grandes logros. El Dr Csendes es Profesor Titular y Emérico de la Universidad de Chile, ha sido director del departamento de cirugía del hospital clínico de la universidad de chile por 18 años, miembro de 32 sociedades de cirugía internacionales, autor de 8 libros de cirugia, autor de 572 publicaciones, past president de la sociedad de cirujanos de chile , miembro del Americal Chemical Society y del American Surgical Association, así como invitado oficial de más de 230 congresos internacionales. El tema elegido para este episodio es el Cáncer Gástrico ya que durante su trayectoria, el Dr Csendes fue a Japón a estudiar Cáncer Gástrico Incipiente y fue distinguido por la Sociedad Internacional de cirugía como uno de los 10 cirujanos latinoamericanos que mayores contribuciones han hecho al progreso y difusión del cáncer gástrico y reflujo gastroesofágico.
In this episode, Imani and Reginald discuss with Dr. Backhus and Dr. Goodney the historical implications of the longstanding poor relationship between the Black community and the medical community, and its effect on current practices and patient care in vascular surgery. They also explore the role of research in creating demonstrable changes in practice to aid in ameliorating this relationship. Leah Backhus, MD, MPH, FACS (@leahbackhusmd) practices at Stanford Hospital and is Chief of Thoracic Surgery at the VA Palo Alto, where she focuses on thoracic oncology and minimally invasive surgical techniques. She is also Co-Director of the Thoracic Surgery Clinical Research Program and has grant funding through the Veterans Affairs Administration and NIH. Her current research interests are in imaging surveillance following treatment for lung cancer and cancer survivorship. She is a member of the National Lung Cancer Roundtable of the American Cancer Society serving as Chair of the Task Group on Lung Cancer in Women. She also serves on the Board of Directors of the Society of Thoracic Surgeons. As an educator, Dr. Backhus is the Associate Program Director for the Thoracic Track Residency and is the Chair of the ACGME Residency Review Committee for Thoracic Surgery. Phillip Goodney MD, MS (@DartmthSrgHSR) is a vascular surgeon, health services researcher, Vice-Chair of Research in the Department of Surgery, Director of the Center for the Evaluation of Surgical Care at Dartmouth (CESC), and Co-Director of the VA Outcomes Group at Veterans Affairs Medical Center in White River Junction, Vermont. His research interests include outcomes assessment using both quantitative and qualitative methods, clinical trials, patient preferences, and shared decision making. He received a Career Development Award from the National Heart, Lung, and Blood Institute in 2010, the Lifeline Research Award from the Society for Vascular Surgery (SVS), and research funding from VA HSR&D, PCORI, FDA, and others. He was elected to the American Surgical Association in 2016 and serves on multiple editorial boards of surgical, cardiovascular, and health services journals. Background The U.S. Public Health Service Syphilis Study at Tuskegee American Eugenics and Forced Sterilization The Story of Henrietta Lacks Johns Hopkins NP Colonoscopy Training Additional Resources: Warren et al. (2020) “Trustworthiness before Trust — Covid-19 Vaccine Trials and the Black Community.” NEJM, 383(22) Blanchard et al.(2020) “A Sense of Belonging.” NEJM, 383(15): 1409–1411 Armstrong et al. (2007) “Racial/Ethnic Differences in Physician Distrust in the United States.” AJPH. 97(7): 1283–1289. DeShazo, Richard D. (2020) The Racial Divide in American Medicine: Black Physicians and the Struggle for Justice in Health Care. University Press of Mississippi. Jacobs et al. (2006) “Understanding African Americans' Views of the Trustworthiness of Physicians.” JGIM. 21(6): 642–647 Frakt, Austin. (2020) “Bad Medicine: The Harm That Comes From Racism.” The New York Times. Tweedy, Damon. (2016) Black Man in a White Coat: a Doctor's Reflections on Race and Medicine. Picador, Armstrong et al. (2013) “Prior Experiences of Racial Discrimination and Racial Differences in Health Care System Distrust.” Medical Care. 51(2): 144–150 Greenwood et al. (2018) “Patient–physician gender concordance and increased mortality among female heart attack patients” PNAS. 115(34): 8569-8574. SVS Foundation VISTA Program Host Introductions Imani McElroy, MD, MPH (@IEMcElroy) is a general surgery resident at the Massachusetts General Hospital in Boston, MA. Reginald Nkansah, MD (@NkansahReginald) is a first-year vascular surgery resident at the University of Wahington in Seattle, WA. What other topics would you like to hear about? Let us know more about you and what you think of our podcast through our Listener Survey or email us at AudibleBleeding@vascularsociety.org. Follow us on Twitter @audiblebleeding Learn more about us at https://www.audiblebleeding.com/about-1/ and #jointheconversation.
This episode features Dr. Courtney Townsend, MD, FACS. He did both his medical school and residency training at the University of Texas Medical Branch and a fellowship in surgical oncology at the University of California Los Angeles. Throughout his time in medicine, Dr. Townsend has served many roles including: President of the American College of Surgeons, President of the American Surgical Association, Director of the American Board of Surgery, and Chair of Surgery at UTMB - to name a few. He is the editor-in-chief for Sabiston Textbook of Surgery. In this episode, we talk about what it's like to apply to a surgical residency and the things applicants should consider to be successful - along with general medical and life advice from a man that may know a little about both.RESOURCES:https://www.facs.org/member-services/join/medical-student https://theasgs.org/ EMAIL:Dr. Townsend: ctownsen@utmb.eduMe: atmeffor@utmb.eduPlease feel free to contact us with any questions or comments. See you guys in the next one!
In this episode we were honoured to once again have another icon of trauma surgery join us. Dr. Ernest E. Gene Moore is a trauma surgeon at the Denver General Hospital. In this episode we explore Dr. Moore’s early insights into the developments of acute care surgery as a specialty, how he defined not one but two major surgery journals, and how he continues to think about the evolution of surgery moving forward. Ernest E. “Gene” Moore, MD, was the Chief of Trauma at the Denver General Hospital for 36 years, Chief of Surgery for 28 years, and the first Bruce M. Rockwell Distinguished Chair in Trauma Surgery. He continues to serve as Vice Chairman for Research and is a Distinguished Professor of Surgery at the University of Colorado Denver (UCD), and has been the Editor of the Journal of Trauma since 2011. Under Dr. Moore’s leadership, the Rocky Mountain Regional Trauma Center at Denver General became internationally recognized for innovative care of the injured patient, and its trauma research laboratory has been funded by the NIH for 35 consecutive years. In July 2018, the center was renamed the Ernest E Moore Shock Trauma Center at Denver Health. Dr. Moore has served as president of nine academic societies, including the Society of University Surgeons, American Association for the Surgery of Trauma, International Association for the Trauma and Surgical Intensive Care, and the World Society of Emergency Surgery; and as Vice President for the American Surgical Association. His awards include the Robert Danis Prize from the Society of International Surgeons, Orazio Campione Prize from the World Society of Emergency Surgery, Philip Hench Award from the University of Pittsburgh, Florence Sabin Award from the University of Colorado, Lifetime Achievement Award from the Society of University Surgeons, Lifetime Achievement Award for Resuscitation Science from the American Heart Association, Distinguished Investigator Award from the American College of Critical Medicine, Distinguished Investigator Award from the Shock Society, Lifetime Service Award from the International Association for Trauma and Surgical Intensive Care, and the Medallion for Scientific Achievement from the American Surgical Association. He has honorary fellowships in the Royal College of Surgeons of Edinburgh, the Royal College of Surgeons in Ireland, the Royal College of Surgeons of Thailand, and the American College of Emergency Physicians; and is an honorary member of the Brazilian Trauma Society, Colombian Trauma Society, Eastern Association for the Surgery of Trauma, European Society for Trauma and Emergency Surgery, North Pacific Surgical Association, and Trauma Association of Canada. Dr. Moore is coeditor of the textbook Trauma, in its 9th edition, Surgical Secrets in its 7th edition, and Trauma Induced Coagulopathy, in its 2nd edition; he has >1700 publications and has lectured extensively throughout the world. He is married to Sarah Van Duzer Moore, M.D., an internist at the University of Colorado Denver, and they have two sons; Hunter, a transplant fellow at UCD and Peter, a pulmonary/critical care fellow, both at UCD. Dr. Moore’s additional interests include endurance sports, mountaineering, skiing, and wapiti pursuit. He lives by the principle to work hard you must play hard, with the understanding that family is the ultimate priority. Links 1. AAST Interview w/ Dr. Moore: http://www.aast.org/assets/f658eae6-95c2-4258-9df0-58344a846882/635338644875870000/23-ernest-e-gene-moore-md-1993-1994-pdf 2. Dedication of Ernest E Moore Shock Trauma Center: https://www.denverhealth.org/news/2018/07/dedication-of-the-ernest-e-moore-shock-trauma-center-at-denver-health 3. WSES tribute to Dr. Moore: https://wjes.biomedcentral.com/articles/10.1186/s13017-018-0206-1
Dr. Keith D. Lillemoe received his undergraduate education at the University of South Dakota and his MD from The Johns Hopkins University School of Medicine in 1978. He served his surgical training at Hopkins and joined the faculty there in 1985, rising to the rank of Professor of Surgery in 1996. He served as Associate Program Director for the Hopkins Surgical Residency from 1993 to 2003 and Vice-Chairman of the department from 1997 to 2003. He was recognized with the Hopkins Department of Surgery Faculty Teaching Award on five occasions. In 2003, he was appointed the Jay L. Grosfeld Professor and Chairman of the Department of Surgery at the Indiana University School of Medicine. In May 2011, Dr. Lillemoe was appointed to the position of Surgeon-in-Chief and Chief of the Department of Surgery at the Massachusetts General Hospital and the W. Gerald Austen Professor of Surgery at the Harvard Medical School. Dr. Lillemoe’s clinical research interests are in pancreatic cancer, IPMNs and other benign pancreatic disorders and biliary tract injuries. His bibliography lists over 500 journal articles and 140 book chapters. He has served as a visiting professor over 120 times and has spoken nationally and internationally on over 500 occasions. He is the former Editor of one of the leading surgical texts Surgery: Scientific Principles and Practice and is Editor-in-Chief of Annals of Surgery. We spoke to him about his training, equity & diversity in surgery, bile duct injuries, and being the Editor-in-Chief at one of the biggest journals in the world. Links: 1. American Surgical Association meeting address: https://www.youtube.com/watch?v=lDiYB1sIqpg 2. Bile duct injuries on Behind the Knife podcast: https://behindtheknife.org/?p=2398 3. Safe cholecystectomy consensus conference: https://journals.lww.com/annalsofsurgery/Abstract/9000/Safe_Cholecystectomy_Multi_society_Practice.94547.aspx 4. Visual Abstracts: https://www.surgeryredesign.com/resources
My guest on today's podcast and former guest on my show "", Dr. Steven Gundry proposes in his new book "", that the “diseases of aging” we most fear are not simply a function of age; but rather, they are a byproduct of the way we have lived over the decades. In The Longevity Paradox, he maps out a new approach to aging well—one that is based on supporting the health of the “oldest” parts of us: the microorganisms that live within our bodies. He believes that - from diseases like cancer and Alzheimer’s to common ailments like arthritis to our weight and the appearance of our skin, these bugs are in the driver’s seat, controlling our quality of life as we age. Dr. Gundry is a cum laude graduate of Yale University with special honors in Human Biological and Social Evolution. After graduating Alpha Omega Alpha from the Medical College of Georgia School of Medicine, Dr. Gundry completed residencies in General Surgery and Thoracic Surgery at the University of Michigan and served as a Clinical Associate at the National Institutes of Health. There, he invented devices that reverse the cell death seen in acute heart attacks; variations of these devices subsequently became the Gundry™ Retrograde Cardioplegia Cannula. It has become the world’s most widely used device of its kind to protect the heart from damage during open-heart surgery. After completing a fellowship in congenital heart surgery at The Hospital for Sick Children, Great Ormond Street, in London, Dr. Gundry was recruited as Professor and Chairman of Cardiothoracic Surgery at Loma Linda University Medical Center. There, he and his partner, Leonard Bailey, pioneered infant and pediatric heart transplantation. Together, they have performed more such transplants than any other surgeons in the world. During his tenure at Loma Linda, Dr. Gundry pioneered the field of xenotransplantation, the study of how the genes of one species react to the transplanted heart of a foreign species. He was one of the original twenty investigators of the first FDA-approved implantable left ventricular assist device (a kind of artificial heart). Dr. Gundry is also the inventor of the Gundry Ministernomy, the widely used minimally invasive approach to aortic- or mitral-valve repair, the Gundry Lateral Tunnel, a “living” tissue that can rebuild parts of the heart in children with severe congenital heart malformations; and the Skoosh™ venous cannula, the most widely used cannula in minimally invasive heart operations. One of the fathers of robotic surgery, as a consultant to Computer Motion (now ), Dr. Gundry received early FDA approval to use robotic-assisted minimally invasive surgery for coronary artery-bypass and mitral-valve operations. He holds patents on devices for connecting blood vessels and coronary artery bypasses without sutures, as well as for repairing the mitral valve without the need for sutures or a heart-lung machine. He has served on the Board of Directors of the American Society of Artificial Internal Organs (ASIAO), and was a founding board member and treasurer of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS). He recently completed two successive elected terms as President of the Board of Directors of the American Heart Association, Desert Division. Dr. Gundry has been elected a Fellow of the American College of Surgeons, the American College of Cardiology, the American Surgical Association, the American Academy of Pediatrics, and the College of Chest Physicians. He is a member of numerous other surgical and medical societies. He is also the author of more than three hundred articles, chapters, and abstracts in peer-reviewed journals on surgical, immunology, genetic, nutrition, and lipid investigations. He has operated in more than thirty countries, including charitable missions to China, India, and Zimbabwe. Inspired by the stunning reversal of coronary artery disease in an “inoperable” patient, using a combination of dietary changes and nutriceutical supplements, in 2001, Dr. Gundry changed the path of his career. An obese, chronic “diet” failure himself, he adapted his undergraduate Yale University thesis to design a diet based on evolutionary genetic coding, which enabled him to reverse his own medical problems. In the process, he effortlessly lost 70 pounds. The equally astonishing results from following what he came to call Diet Evolution in several of his staff led Dr. Gundry to accept a position in Palm Springs where he could devote his efforts to disease reversal. No longer satisfied with repairing the damage of chronic diseases, since 2002, Dr. Gundry founded and has served as Medical Director of The International Heart and Lung Institute in Palm Springs, California, which serves patients referred from across the nation. He is also Founder and Director of The Center for Restorative Medicine, part of the Institute. Its mission is to prevent and reverse the chronic diseases of “ageing” with diet and nutriceutical interventions, using surgical intervention for heart and vascular disease as a last resort. During our discussion, you'll discover: -The myth of the Mediterranean Diet promoting longevity...11:20 "Blue Zones" is a term coined by a journalist named Dan Bruckner Dr. Gundry has spent most of his life living in a Blue Zone (Loma Linda, CA) Doesn't disagree with the premise you should follow the Mediterranean Diet, but there's more to it... "The only purpose of food is to get olive oil in your mouth" The key to the Mediterranean Diet is not whole grains and beans Book: Residents of Acciaroli, Italy do not eat pasta or bread, but love lentil beans Millet, sorgum, teft do not have a hull (where most of the defense mechanisms of the plant are located) Unprocessed barley: People live a long time in spite of it, not because of it Influence of the Greek Orthodox church on the Mediterranean Diet Fasting and abstaining from animal products are observed during Lent -The missing link in the Mediterranean Diet regarding longevity...20:45 , a compound that is deleterious to the surface of blood vessels Cleveland Clinic invented a test to detect TMAO Recognized low incidence of coronary artery disease in spite of animal product consumption Present in most olive oils, balsamic vinegars and red wines A structural analog of choline Not all TMAO is created equal The ideal Mediterranean Diet (Hint: Olive Garden got it wrong) Rich in polyphenols, olive oil and red wine More fish and eggs than meat Some type of fasting component You can mitigate a bad diet with a fast or fasting mimicking diet for 5 consecutive days Done on a quarterly basis The Carnivore Diet is a fad, fancy name for the Atkins Diet -The carbohydrate Okinawans consume that staves off inflammation and high blood sugar...27:40 ~85% of the traditional Okinawan diet is a blue or purple sweet potato 5-6% of the diet white rice (no brown rice) Remaining soy-based products and pig fat Taro and sweet potatoes are resistance starches "The more we eat for our gut microbiome, the more our gut microbiome will take care of us." Nigerians carry the highest percentage of APO E-4 gene of any people on earth Their starch is melon Very low rate of Alzheimers -Dr. Gundry's thoughts on roughage and fiber intake...35:14 went on a mission to Africa to operate on colon cancer Realized no one had colon cancer Studied their stools Eating huge amount of tubers (yams) and millet Didn't realize there was a difference between soluble and insoluble fiber Advocated for eating whole grains Ended up dying of colon cancer Lives in tunnels in sub-saharan Africa Lives 30x longer than other rats Gut microbiome is identical of healthy 105 year old humans Eats tubers, roots and fungi -The myth of the efficacy of animal protein for longevity...42:45 US Dept of Agriculture sells agricultural products (owns the food pyramid) Vegans live the longest The more animal protein consumed, the less the longevity You can mitigate meat intake with a vegan fast or fasting mimicking diet for 5 days consecutively Methionine/glycine ratio People who are primarily carnivorous do not historically have the highest longevity -The myth of growth hormones...49:20 Loranz people of Ecuador do not have cancer or diabetes When block IGF-1 receptor in mice, live 40% longer When give growth hormones, abolishes effect of calorie restriction Supplement with quercetin -The myth of iron intake for longevity...55:05 Iron is one of the deadliest substances Iron is dangerous for mitochondrial function Regular blood donors have longer life spans than non-donors Endurance training helps reduce iron levels Ferritin and GGT are musts for a blood test to track "internal rust" Ferritin is a great marker for inflammation Elevated level indicates potential auto-immune disease -The myth of metabolic rate...59:50 Age is akin to rate of energy consumption Carnivores run higher temperatures than herbivores; breakdown of protein generates a lot of heat Sweet spot between fitness and low metabolism: Hibernating animals can live 2-3x longer than non-hibernating animals due to reduced metabolic rate There are periods we should have less energy expenditure than others We live in constant summer, regardless of where we live in the world -The myth of saturated fat...1:05:15 Dr. Ancel Keys published the Said saturated fat was related to coronary heart disease He did not say plant fats were bad for you (although it was implied) Retired near Acciorili and ate large amounts of olive oil Did not make the connection between animal fat and animal protein 30% of people carry APO E 4 gene Saturated fats in coconut oil, cheese increase LDL's in these people Mucus absorbs lectins; is essential for gut health in older age -Why milk does not in fact do the body good... Most milk in the US is casein a1 milk, from holstein cows Cow milk is designed to make baby cows grow quickly (lots of IGF1) Humans are designed to grow slowly (low amounts of IGF1) Adolescents who grow quickly have higher chance of cancer in 10-20 years We're the only animal that drinks another animal's milk Ben's kids drink goat and camel milk -And much more... Resources from this episode: -Book: -Book: -Book: -Book: - - - on the growing epidemic of loneliness and relationships/longevity. - - - - - - Episode Sponsors: -: My personal playground for new supplement formulations. Ben Greenfield Fitness listeners receive a 10% discount off your entire order when you use discount code: BGF10. -: A new take on an ancient secret: Pain-soothing herbs, incredible antioxidants, and phytonutrients all in one delicious, soothing “Golden Milk” nighttime tea! Receive a 20% discount on your entire order when you use discount code: BENG20. -: You can be sure that I researched all the saunas before I bought mine and Clearlight was the one that stood out from all the rest because of their EMF and ELF Shielding and their Lifetime Warranty. Use discount code: BENGREENFIELD to get $500 off your sauna and a free bonus gift! -: As your qualified candidates roll in, we make it easy to screen & rate them, allowing you to make the best hiring decisions for your business. Try it for free when you use ! Do you have questions, thoughts or feedback for Dr. Gundry or me? Leave your comments below and one of us will reply!
NYT Bestselling author of The Plant Paradox: The Hidden Dangers in "Healthy" Foods That Cause Disease & The Longevity Paradox: How to Die Young At a Ripe Old Age. STEVEN R. GUNDRY, M.D., F.A.C.S., F.A.C.C., is a cum laude graduate of Yale University with special honors in Human Biological and Social Evolution. After graduating Alpha Omega Alpha from the Medical College of Georgia School of Medicine, Dr. Gundry completed residencies in General Surgery and Thoracic Surgery at the University of Michigan and served as a Clinical Associate at the National Institutes of Health. There, he invented devices that reverse the cell death seen in acute heart attacks; variations of these devices subsequently became the Gundry™ Retrograde Cardioplegia Cannula. It has become the world's most widely used device of its kind to protect the heart from damage during open-heart surgery. After completing a fellowship in congenital heart surgery at The Hospital for Sick Children, Great Ormond Street, in London, Dr. Gundry was recruited as Professor and Chairman of Cardiothoracic Surgery at Loma Linda University Medical Center. There, he and his partner, Leonard Bailey, pioneered infant and pediatric heart transplantation. Together, they have performed more such transplants than any other surgeons in the world. During his tenure at Loma Linda, Dr. Gundry pioneered the field of xenotransplantation, the study of how the genes of one species react to the transplanted heart of a foreign species. He was one of the original twenty investigators of the first FDA-approved implantable left ventricular assist device (a kind of artificial heart). Dr. Gundry is also the inventor of the Gundry Ministernomy, the widely used minimally invasive approach to aortic- or mitral-valve repair, the Gundry Lateral Tunnel, a "living" tissue that can rebuild parts of the heart in children with severe congenital heart malformations; and the Skoosh™ venous cannula, the most widely used cannula in minimally invasive heart operations. One of the fathers of robotic surgery, as a consultant to Computer Motion (now Intuitive Surgical), Dr. Gundry received early FDA approval to use robotic-assisted minimally invasive surgery for coronary artery-bypass and mitral-valve operations. He holds patents on devices for connecting blood vessels and coronary artery bypasses without sutures, as well as for repairing the mitral valve without the need for sutures or a heart-lung machine. He has served on the Board of Directors of the American Society of Artificial Internal Organs (ASIAO), and was a founding board member and treasurer of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS). He recently completed two successive elected terms as President of the Board of Directors of the American Heart Association, Desert Division.Dr. Gundry has been elected a Fellow of the American College of Surgeons, the American College of Cardiology, the American Surgical Association, the American Academy of Pediatrics, and the College of Chest Physicians. He is a member of numerous other surgical and medical societies. He is also the author of more than three hundred articles, chapters, and abstracts in peer-reviewed journals on surgical, immunology, genetic, nutrition, and lipid investigations. He has operated in more than thirty countries, including charitable missions to China, India, and Zimbabwe.Inspired by the stunning reversal of coronary artery disease in an "inoperable" patient, using a combination of dietary changes and nutriceutical supplements, in 2001, Dr. Gundry changed the path of his career. An obese, chronic "diet" failure himself, he adapted his undergraduate Yale University thesis to design a diet based on evolutionary genetic coding, which enabled him to reverse his own medical problems. In the process, he effortlessly lost 70 pounds. The equally astonishing results from following what he came to call Diet Evolution in several of his staff led Dr. Gundry to accept a position in Palm Springs where he could devote his efforts to disease reversal. No longer satisfied with repairing the damage of chronic diseases, since 2002, Dr. Gundry founded and has served as Medical Director of The International Heart and Lung Institute in Palm Springs, California, which serves patients referred from across the nation. He is also Founder and Director of The Center for Restorative Medicine, part of the Institute. Its mission is to prevent and reverse the chronic diseases of "ageing" with diet and nutriceutical interventions, using surgical intervention for heart and vascular disease as a last resort. Dr. Gundry lives with his wife, Penny and their four dogs, George, Bella, Black Pearl, and Fanny Foo Foo in Palm Springs and Montecito, California. His two grown daughters live nearby.Please do NOT hesitate to reach out to me on LinkedIn, Instagram, or via email mark@vudream.comLinkedIn - https://www.linkedin.com/in/mark-metry/Instagram - https://www.instagram.com/markmetry/Twitter - https://twitter.com/markymetryMedium - https://medium.com/@markymetryFacebook - https://www.facebook.com/Humans.2.0.PodcastMark Metry - https://www.markmetry.com/Humans 2.0 Twitter - https://twitter.com/Humans2Podcast
NYT Bestselling author of The Plant Paradox: The Hidden Dangers in "Healthy" Foods That Cause Disease & The Longevity Paradox: How to Die Young At a Ripe Old Age. STEVEN R. GUNDRY, M.D., F.A.C.S., F.A.C.C., is a cum laude graduate of Yale University with special honors in Human Biological and Social Evolution. After graduating Alpha Omega Alpha from the Medical College of Georgia School of Medicine, Dr. Gundry completed residencies in General Surgery and Thoracic Surgery at the University of Michigan and served as a Clinical Associate at the National Institutes of Health. There, he invented devices that reverse the cell death seen in acute heart attacks; variations of these devices subsequently became the Gundry™ Retrograde Cardioplegia Cannula. It has become the world's most widely used device of its kind to protect the heart from damage during open-heart surgery. After completing a fellowship in congenital heart surgery at The Hospital for Sick Children, Great Ormond Street, in London, Dr. Gundry was recruited as Professor and Chairman of Cardiothoracic Surgery at Loma Linda University Medical Center. There, he and his partner, Leonard Bailey, pioneered infant and pediatric heart transplantation. Together, they have performed more such transplants than any other surgeons in the world. During his tenure at Loma Linda, Dr. Gundry pioneered the field of xenotransplantation, the study of how the genes of one species react to the transplanted heart of a foreign species. He was one of the original twenty investigators of the first FDA-approved implantable left ventricular assist device (a kind of artificial heart). Dr. Gundry is also the inventor of the Gundry Ministernomy, the widely used minimally invasive approach to aortic- or mitral-valve repair, the Gundry Lateral Tunnel, a "living" tissue that can rebuild parts of the heart in children with severe congenital heart malformations; and the Skoosh™ venous cannula, the most widely used cannula in minimally invasive heart operations. One of the fathers of robotic surgery, as a consultant to Computer Motion (now Intuitive Surgical), Dr. Gundry received early FDA approval to use robotic-assisted minimally invasive surgery for coronary artery-bypass and mitral-valve operations. He holds patents on devices for connecting blood vessels and coronary artery bypasses without sutures, as well as for repairing the mitral valve without the need for sutures or a heart-lung machine. He has served on the Board of Directors of the American Society of Artificial Internal Organs (ASIAO), and was a founding board member and treasurer of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS). He recently completed two successive elected terms as President of the Board of Directors of the American Heart Association, Desert Division.Dr. Gundry has been elected a Fellow of the American College of Surgeons, the American College of Cardiology, the American Surgical Association, the American Academy of Pediatrics, and the College of Chest Physicians. He is a member of numerous other surgical and medical societies. He is also the author of more than three hundred articles, chapters, and abstracts in peer-reviewed journals on surgical, immunology, genetic, nutrition, and lipid investigations. He has operated in more than thirty countries, including charitable missions to China, India, and Zimbabwe.Inspired by the stunning reversal of coronary artery disease in an "inoperable" patient, using a combination of dietary changes and nutriceutical supplements, in 2001, Dr. Gundry changed the path of his career. An obese, chronic "diet" failure himself, he adapted his undergraduate Yale University thesis to design a diet based on evolutionary genetic coding, which enabled him to reverse his own medical problems. In the process, he effortlessly lost 70 pounds. The equally astonishing results from following what he came to call Diet Evolution in several of his staff led Dr. Gundry to accept a position in Palm Springs where he could devote his efforts to disease reversal. No longer satisfied with repairing the damage of chronic diseases, since 2002, Dr. Gundry founded and has served as Medical Director of The International Heart and Lung Institute in Palm Springs, California, which serves patients referred from across the nation. He is also Founder and Director of The Center for Restorative Medicine, part of the Institute. Its mission is to prevent and reverse the chronic diseases of "ageing" with diet and nutriceutical interventions, using surgical intervention for heart and vascular disease as a last resort. Dr. Gundry lives with his wife, Penny and their four dogs, George, Bella, Black Pearl, and Fanny Foo Foo in Palm Springs and Montecito, California. His two grown daughters live nearby.Please do NOT hesitate to reach out to me on LinkedIn, Instagram, or via email mark@vudream.comLinkedIn - https://www.linkedin.com/in/mark-metry/Instagram - https://www.instagram.com/markmetry/Twitter - https://twitter.com/markymetryMedium - https://medium.com/@markymetryFacebook - https://www.facebook.com/Humans.2.0.PodcastMark Metry - https://www.markmetry.com/Humans 2.0 Twitter - https://twitter.com/Humans2Podcast
Talk about making your mark on medicine. From a small town in Argentina where his parents were the only physicians, to the presidency of the American Surgical Association and his tenure as Chief Medical Officer at University of Washington Medicine, Carlos Pellegrini,MD's career has been nothing short of a tour de force. In this special edition of Docs Talk, Dr. Pellegrini joins host Josh Kerns for an insightful, thought provoking, and at times humorous conversation spanning his decades as a leader and innovator in medicine. Dr. Pellegrini recently retired from UW Medicine after serving as CMO for the past three years. Prior to that, he served as the chair of the UW Medicine surgery department for 23 years. UW Medicine CEO Paul Ramsey, MD, said, "As department chair, Dr. Pellegrini was an exemplary role model for the UW Medicine Patients Are First approach to clinical care. He was a mentor to faculty, staff and students, and he focused on developing relationships to bring people together as the best way to advance the profession. His work to advance the Department of Surgery included helping to raise more than $30 million from patients and community supporters to create several chairs and professorships. In addition, with his wife, Kelly, he made significant personal donations to create a fellowship in surgical ethics, a fellowship in education, and the Carlos and Kelly Pellegrini fund for diversity." "His impact as CMO has been equally significant," Ramsey added.
This is the second episode of our journal club series with Annals of Surgery. In this episode, Dr. Kaafarani will discuss his recent paper "Surgical Risk Is Not Linear: Derivation and Validation of a Novel, User-friendly, and Machine-learning-based Predictive OpTimal Trees in Emergency Surgery Risk (POTTER) Calculator," presented at the 2018 meeting of the American Surgical Association and recently published in Annals of Surgery. The full text is currently available online, free of charge for Behind the Knife listeners: https://journals.lww.com/annalsofsurgery/Abstract/publishahead/Surgical_Risk_Is_Not_Linear___Derivation_and.95426.aspx Episode hosts: Shreya Gupta (@shrey3467), Meghana Kashyap (@pubMEG), Karan Chhabra (@krchhabra) You can download the calculator following this link: http://jack.dunn.nz/nsqip-vis/question4.html
https://bengreenfieldfitness.com/gundry Grains of all kinds, especially whole grain wheat. Corn. Tomatoes. Potatoes. Beans and legumes, particularly soy. Just about all nuts, especially cashews and peanuts. Zucchini, bell peppers, eggplant and pickles. And yes, even our dear friend the avocado. Each of these foods has one thing in common - a food component that today's podcast guest, , claims may responsible for some of the world's most pressing health issues, from obesity to heart disease. In Dr. Gundry's new book , he highlights exactly what that foood component is. Dr. Gundry is a renowned cardiologist, New York Times best-selling author and medical researcher. During his 40-year career in medicine, he has performed over 10,000 heart surgeries and developed multiple life-saving medical technologies, including patenting nine cardiac surgery devices. He is a cum laude graduate of Yale University with special honors in Human Biological and Social Evolution. After graduating Alpha Omega Alpha from the Medical College of Georgia School of Medicine, Dr. Gundry completed residencies in General Surgery and Thoracic Surgery at the University of Michigan and served as a Clinical Associate at the National Institutes of Health. There, he invented devices that reverse the cell death seen in acute heart attacks; variations of these devices subsequently became the Gundry™ Retrograde Cardioplegia Cannula. It has become the world’s most widely used device of its kind to protect the heart from damage during open-heart surgery. After completing a fellowship in congenital heart surgery at The Hospital for Sick Children, Great Ormond Street, in London, Dr. Gundry was recruited as Professor and Chairman of Cardiothoracic Surgery at Loma Linda University Medical Center. There, he and his partner, Leonard Bailey, pioneered infant and pediatric heart transplantation. Together, they have performed more such transplants than any other surgeons in the world. During his tenure at Loma Linda, Dr. Gundry pioneered the field of xenotransplantation, the study of how the genes of one species react to the transplanted heart of a foreign species. He was one of the original twenty investigators of the first FDA-approved implantable left ventricular assist device (a kind of artificial heart). Dr. Gundry is also the inventor of the Gundry Ministernomy, the widely used minimally invasive approach to aortic- or mitral-valve repair, the Gundry Lateral Tunnel, a “living” tissue that can rebuild parts of the heart in children with severe congenital heart malformations; and the Skoosh™ venous cannula, the most widely used cannula in minimally invasive heart operations. One of the fathers of robotic surgery, as a consultant to Computer Motion (now Intuitive Surgical), Dr. Gundry received early FDA approval to use robotic-assisted minimally invasive surgery for coronary artery-bypass and mitral-valve operations. He holds patents on devices for connecting blood vessels and coronary artery bypasses without sutures, as well as for repairing the mitral valve without the need for sutures or a heart-lung machine. He has served on the Board of Directors of the American Society of Artificial Internal Organs (ASIAO), and was a founding board member and treasurer of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS). He recently completed two successive elected terms as President of the Board of Directors of the American Heart Association, Desert Division. Dr. Gundry has been elected a Fellow of the American College of Surgeons, the American College of Cardiology, the American Surgical Association, the American Academy of Pediatrics, and the College of Chest Physicians. He is a member of numerous other surgical and medical societies. He is also the author of more than three hundred articles, chapters, and abstracts in peer-reviewed journals on surgical, immunology, genetic, nutrition, and lipid investigations. He has operated in more than thirty countries, including charitable missions to China, India, and Zimbabwe. Inspired by the stunning reversal of coronary artery disease in an “inoperable” patient, using a combination of dietary changes and nutriceutical supplements, in 2001, Dr. Gundry changed the path of his career. An obese, chronic “diet” failure himself, he adapted his undergraduate Yale University thesis to design a diet based on evolutionary genetic coding, which enabled him to reverse his own medical problems. In the process, he effortlessly lost 70 pounds. The equally astonishing results from following what he came to call Diet Evolution in several of his staff led Dr. Gundry to accept a position in Palm Springs where he could devote his efforts to disease reversal. No longer satisfied with repairing the damage of chronic diseases, since 2002, Dr. Gundry founded and has served as Medical Director of The International Heart and Lung Institute in Palm Springs, California, which serves patients referred from across the nation. He is also Founder and Director of The Center for Restorative Medicine, part of the Institute. Its mission is to prevent and reverse the chronic diseases of “ageing” with diet and nutriceutical interventions, using surgical intervention for heart and vascular disease as a last resort. During today's discussion with Dr. Gundry, you'll discover: -What exactly a lectin is, and why plants have them...[6:56] -What happens to the gut upon consumption of lectins, and whether there's any research behind it...[9:25 ] -The common (and uncommon) sources of lectins that most people eat...[20:35] -How a lectin is different than gluten...[21:35 & 30:10] -Whether our ancestors ate plants and lectins...[31:10 & 44:50] -Why Steven is such a fan of eating fruit that’s in season, or fruit that is unripened...[36:45] -Why Steven thinks it is that so many of the Blue Zones in Dan Buettner's longevity book had a propensity for eating legumes, yet still lived long...[48:45] -Simple hacks you can use to reduce lectins in common foods like tomatoes, peppers, potatoes, apple, rice, etc...[39:55, 43:25 & 55:50] -And much more! Resources from this episode: Show Sponsors: -Atrantil - Go to and use the code Ben for 15% off. -Rover - The nation's largest network of 5-star pet-sitters. Go to and use promo code "BEN" to get $25 off. -HealthIQ - To learn more about life insurance for physically active people and get a free quote, go to . -Qualia - Go to to fine tune your brain for cognitive fitness. Do you have questions, thoughts or feedback for Dr. Gundry or me? Leave your comments at and one of us will reply!