Podcasts about e prime

What happens when you remove an entire verb from the English language? Chaos! Well, not quite. But it used to cause Kathy quite a bit of consternation. Also: we try to nail down the correct spellings of various grunts and murmurs.

Il Genoa riprende ad allenarsi ed entra nella settimana "tipo" che porta all'esordio in Serie A. Ripartiamo dalle ultime da Pegli passando per l'ultimo innesto classe 2007 Nsingi, per i possibili futuri innesti e per i nuovi staff del Genoa Women, che venerdì 22 agosto esordirà ufficialmente. Buoncalcioatutti!

In questa puntata ti parlo della mia esperienza iniziale con la developer beta iPadOS 26. Ascolta tutto …

Edge of eternities è la nuova spaziale espansione di MTG che uscirà il primo agosto. Oggi parliamo degli spoiler, delle art e delle carte astronavi!Trovi il video dell'episodio qui: https://www.youtube.com/channel/UCMkQqseTypha6-n8Lsba6KwLINK per il canale Telegram: https://t.me/+dXU4Ko4N2CszODRkIn Risposta Scombo è sponsorizzato da Fantasia store, il paradiso di tutti noi nerd! Sul loro store troverete tutto ciò che un giocatore di Magic può desiderare!

In questo video do un primo sguardo al regolamento di Taf!, il gioco da tavolo che porta il caos e la rissa direttamente sul tavolo! Leggo ad alta voce le prime sezioni del manuale, commentando insieme le regole più curiose e lo spirito scanzonato del gioco. Se vuoi capire di cosa si tratta prima di buttarti nella mischia, questo video fa per te!

Nicolas Maupas è il nuovo ospite di Super Otto! Abbiamo parlato di Mare Fuori, della sua passione per il fantasy, di adolescenza e prime volte.Dopo il successo di Mare Fuori, Nicolas Maupas arriva al cinema con “L'amore, in teoria”, il suo primo film da protagonista. Interpreta Leone, uno studente di filosofia intrappolato tra un amore a senso unico e la paura di lasciarsi andare a qualcosa di più autentico. “L'amore in teoria” racconta il passaggio dall'amore idealizzato a quello reale, dando voce a una generazione che cerca verità nei sentimenti. Dal 24 aprile al cinema!Super Otto è disponibile su tutte le principali piattaforme podcast.

La mezzanotte si avvicina e, come ogni anno, porta con sé abitudini, emozioni e momenti speciali. Abbiamo chiesto agli ascoltatori di SBS Italian di raccontarci come trascorreranno la sera della vigilia e il giorno di Natale.

The paradox of self-sabotage resides in its duality—it acts both as an adversary and as a profound instructor. To explore this dynamic requires a willingness to confront the darker recesses of human behavior and thought. The concept that “being your worst enemy equates to being your greatest teacher” challenges traditional narratives of self-improvement, pushing the boundaries of what we deem productive or harmful. This essay examines the philosophical, psychological, and spiritual dimensions of this paradox, guided by the principles of E-Prime for clarity and precision.

Vamos ver as principais notícias de tecnologia de hoje: novo streaming MAX vai corrigir uma das maiores falhas da HBO Max no Brasil, Galaxy S24 chega com novo modo de recarga adaptativa, Android 15 pode forçar a exibição de apps em tela cheia e muito mais!

In questa nuova puntata torniamo a parlare, da un anno dall'entrata in vigore, del Codice della Crisi per capire insieme cosa sta accadendo a livello di orientamenti giurisprudenziali e di prime prassi operative che si stanno registrando con riguardo all'applicazione del Codice.Approfondiamo questi temi con Luciana Cipolla, Partner dello Studio, Roberta Pagani, Managing Associate e Luca Scaccaglia, Senior Associate.

Garimpeiros & Garimpeiras!! No ar episódio #168 No podcast #TGRbr : Jailson Carvalho, apresenta o programa com participação de Barbara do ninersnews br, Leandro Barbosa, do 49ers mil grau e Jeferson  comentam as principais noticias de Santa Clara, a vitoria contra os Rams  na semana 2 e preview do jogo contra os Giants  /////////////////////////////////////////////////// Uma parceria da FN Network + Sportamerica  Acesse aqui: https://www.sportamerica.com.br Click para aba dos conteúdos Exclusivos e Licenciado dos Niners >>> [APERTE AQUI] /////////////////////////////////////////////////// #TGRBr #49ers #NinersBrasil #NiNãoDaMassa #FTTB #49ersForever #GoNiners Para os torcedores fiéis dos Niners, o local é aqui! Olhos e ouvidos apurados para receber as suas sugestões, comentários e críticas em nossas redes sociais. Fiquem ligados para ouvirem as suas respostas nos próximos episódios! Assine o Feed para não perder nenhum episódio:➤ https://fumblenanet.com.br/feed/thegoldrushbr Twitter:➤ twitter.com/@thegoldrushbr Facebook: (Está morto).➤ facebook.com/thegoldrushbr E-mail:➤ thegoldrushbr@gmail.com Arte feita pelo: Thiago Murta https://www.behance.net/thiagograuna Edição de Podcast: Jailson Carvalho (jonhbrt@gmail.com)

Puntata di sabato 29 luglio con il commento al finale di Secret Invasion, la nuova stagione di Futurama, le uscite di agosto su Netflix, Disney+, Paramount+ e Prime Video, Scurry 2 e i consigli di lettura fumettistici con Luca L'Idea che ti Manca.

Nesse episódio falamos (@bgoncal2 e @faber_goncalves) sobre:Lançamento do ThreadsPrimeiras Impressões + CríticasSensor de Contato Matter da AqaraExperiência do Bruno: Vantagens, defeitos e devaneiosAmazon Prime Day: Descontos? Não sabemos o que é issoHomeTV no Vision ProSigam nosso twitter @outrotechcast ❤️ Nos ajude a continuar produzindo (Patreon) Hosted on Acast. See acast.com/privacy for more information.

So good to see again...

La settimana appena trascorsa è stata quella dei tappeti rossi: quelli delle star (vere) al Met Gala e i miei che in anteprima sono stata invitata a vedere i Guardiani della Galassia Volume 3, l'inaugurazione del nuovo pop up store interattivo dedicato agli appassionati di Stranger Things e un'altra inaugurazione che mi sta particolarmente a cuore: quella del primo store firmato Humana People to People, completamente dedicato al Second Hand. Approfondiamo un po'.

Note della puntata: Lo stop all'acquisizione di Activision Blizzard da parte di Microsoft porta a galla nuove verità: l'industria è troppo costosa e quasi insostenibile, e CoD è improbabile possa venir rimpiazzato da un competitor. Red Fall è arrivato con i suoi gloriosi 30 FPS su console e, soprassedendo, ci ho fatto un giro e non sono troppo contento.  Instagram

Quarta-feira, 05 de abril de 2023 Hoje, com apresentação de Angresson Silva (@fajucast) Veja os destaques de hoje do seu podcast diário de notícias sobre as Comunidades LGBTQIAPN+: Twitter apaga milhares de tuítes sobre manifestação por direitos trans Estudo revela pouca diversidade em papéis no cinema, mas melhor em streaming Prime Video prepara série gay com protagonistas negros Complemento Ouça o Fajucast na sua plataforma favorita _________________________________________________________________ Alguma sugestão de pauta? Comentários? Indicações? Mande Sua Mensagem de Voz para o BOM DIA, BIXA Se quiser, mande um e-mail para bomdiabixa@gmail.com Siga nas redes e fale com a gente na DM: @bomdiabixa no Instagram, Twitter e TikTok _________________________________________________________________ Este podcast integra a @FIOpodcasts | Rede Ativista de Vozes Idealização - GG Pesquisa e Roteiro - Zé Henrique Freitas Identidade Visual, Edição e Produção - Rod Gomes Apresentação - Lua Mansano, Gab Van, Iza Potter, GG, Zé Henrique Freitas, Rod Gomes e Bia Carmo _________________________________________________________________ Não deixe de clicar em SEGUIR o podcast aí no seu player favorito, nem de ativar notificações para não perder nenhum episódio!  Ah, e se compartilhar, não deixe de nos marcar nas redes. ;)

Puntata di sabato 1 aprile con il commento all'episodio di The Mandalorian, il nuovo film Dungeons & Dragons - L'onore dei ladri, le novità sul prequel di Hunger Games, la consueta chiacchierata con Luca de L'Idea che ti Manca questa volta sul fumettista Frank Miller e le principali uscite del mese su Netflix, Prime Video e Disney+

Mix of the Week #471 is "Steady Steppers" by E-Prime Follow and include @e-prime-537008921 in your track ID requests Store: https://www.dreamchimney.com/store Email List: https://www.dreamchimney.com/motw/subscribe Radio: https://www.dreamchimney.com/radio

In this ep, I discuss how something as simple as popping a positive adjective in front of otherwise "negative" stimuli can help interrupt our sympathetic nervous system and stress response and instead create opportunities to be thankful, or joyful in the face of "annoyances". I also briefly discuss Robert Anton Wilson and the use of Eprime.

Nuovo appuntamento in diretta con i giornalisti della redazione di Passione Inter e i membri del Club di Passione Inter che vi offrono il punto della situazione con le principali news sull'Inter di giornata. Nell'episodio di oggi parliamo di Inter-Bologna 6-1, di un super Federico Dimarco e delle prime convocazioni ufficiali delle varie nazionali per i Mondiali in Qatar.

RIP Netflix? Strategie e futuro di un mercato che sembra destinato ad avere dei chiari vincitori. Profilo Instagram "Storie di Brand " - https://www.instagram.com/storiedibrand/ Iscriviti al canale Telegram per rimanere sempre aggiornato/a - https://t.me/storiedibrand SPONSOR che sostengono lo show --> https://znap.link/brandy

Radioimmaginaria CastenasoPodcastBella regaz! Benvenuti su Radioimmaginaria Castenaso! Nella puntata di oggi parleremo un po' delle prime cotte che abbiamo avuto alle medie visto che in redazione a certe di noi servono consigli (e li daremo anche a voi!) e anche di tutte le pazzie che abbiamo fatto per delle persone famose. Stay tuned con Castenaso!radioimmaginaria.it

Episodio 705, in collaborazione con Talking Trek. Oggi di Paramount+ e delle prime impressioni su Star Trek: Strange New Worlds. Attenzione: sono contenuti inevitabili spoiler. Per l'immagine di copertina: © Aventi diritto. All rights reservedSupport this podcast at — https://redcircle.com/fantascienticast/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Puntata di sabato 3 settembre con le novità Marvel She Hulk, Il Trono di Spade Gli Anelli del Potere e Il Signore degli Anelli gli Anelli del Potere. In più le principali uscite di settembre su Netflix, Disney+ e Prime Video

durée : 00:25:14 - 8h30 franceinfo - Le député Rassemblement national de la Somme était l'invité du "8h30 franceinfo" le mercredi 3 août.

Puntata di sabato 2 luglio con il commento alle puntate di Ms Marvel e The Boys uscite in settimana. Grande spazio alle uscite del mese di luglio su Disney+, Prime Video e Netflix con Stranger Things, Better Call Saul e Resident Evil

Puntata di sabato 30 aprile con il commento al quinto episodio di Moon Knight e tutte le uscite più importanti del mese di maggio: Stranger Things, Love Death & Robots, How I Met Your Father, Obi-Wan Kenobi e tante altre. 

Det vi vet är ofta inte så klart som vi tror, särskilt inte om du utforskar det källkritiskt. Detta är intressant på på ett personligt plan eftersom du med rätt frågor kan släppa begränsande övertygelser som släpper fram mer av din potential. Inspirerat av Pippi Långstrump, E-Prime och maybe logic.  En av 86 tekniker i Unpack Your Existence (Amazon). Du når oss på info@enpodomallt.se

Jiunn, Seth, John and Aaron discuss their review experience with the A.C.E. Prime The Sergeant https://developingpalates.com/reviews/cigar-reviews/team-cigar-review-a-c-e-prime-the-sergeant/

It was the best of times, it was the worst of times. The pen is mightier than the sword. Knowledge is power, France is bacon. These, ahem, classic quotes all have something linguistically interesting in common: they're all formed around a particular use of the verb “be” known as a copula. In this episode, your hosts Lauren Gawne and Gretchen McCulloch get enthusiastic about copulas! This is a special name for a way of grammatically linking two concepts together that's linguistically special in a lot of different languages: sometimes it's a verb that's super irregular (like be/is/was in English, Latin, and many other languages), sometimes it's several verbs (like ser and estar in Iberian and Celtic languages), sometimes it's a form of marking other words (like in Nahuatl, Auslan, and ASL), and sometimes it's not even visible or audible at all (like zero copula in Arabic, African American English, and Russian). We also talk about some of the fun things you can do with copulas in English, such as the lexical gap that's filled by “ain't”, the news headline null copula, and the oddball philosophical experiment known as E-Prime. Announcements: We're doing another online Lingthusiasm liveshow on April 9th (Canada) slash 10th (Australia)! (What time is that for me?) It will be a live Q&A for patrons about a fan fave topic: swearing! We'll be hosting this session on the Lingthusiasm patron Discord server. Become a patron before the event, and it will also be available as an edited-for-legibility recording in your usual Patreon live feed if you prefer to listen at a later date. In the meantime: tell us about your favourite examples of swearing in various languages and we might include them in the show! https://www.patreon.com/lingthusiasm LingComm Grants are back in 2022! These are small grants to help kickstart new projects to communicate linguistics to broader audiences. There will be a $500 Project Grant, and ten Startup Grants of $100 each. Apply here by March 31, 2022 or forward this page to anyone you think might be interested, and if you'd like to help us offer more grants, you can support Lingthusiasm on Patreon or contribute directly. We started these grants because a small amount of seed money would have made a huge difference to us when we were starting out, and we want to help there be more interesting linguistics communication in the world. https://lingcomm.org/grants/ For links to things mentioned in this episode:

On this episode the boys explain what an NFT is, give tips for picking an NFT project, Twitter Blue,  China allowing NFTs for purchase H.A.P.E Prime project, Kanye vs Pete Davidson, and celebrate Ozzy's 29th birthday. Follow the Somethings: Instagram:@domjackson747https://www.instagram.com/domjackson747/Twitter:@domjackson747https://twitter.com/domjackson747Instagram:@OAMJRhttps://www.instagram.com/oamjr/​​Twitter:@highskiesllchttps://twitter.com/highskiesllc​

Prepariamoci al weekend dell'All-Star Game a Las Vegas per il quale la NHL ha in serbo due novità pazzesche che vi raccontiamo in questa puntata! E poi le prime voci di mercato: Matthew Tkachuk storce il naso alla proposta di Calgary. Malkin e Letang resteranno a Pittsburgh? E i Panthers vogliono andare all-in sacrificando un importante prospect!

Prepariamoci al weekend dell'All-Star Game a Las Vegas per il quale la NHL ha in serbo due novità pazzesche che vi raccontiamo in questa puntata!E poi le prime voci di mercato: Matthew Tkachuk storce il naso alla proposta di Calgary. Malkin e Letang resteranno a Pittsburgh? E i Panthers vogliono andare all-in sacrificando un importante prospect!

Sexta-feira, 14 de janeiro de 2021 Veja os destaques de hoje do seu podcast diário de notícias LGBTQIAP+: Advogada trans é eleita conselheira da OAB de São Paulo pela 1ª vez em 91 anos - https://razoesparaacreditar.com/advogada-trans-eleita-conselho-oab-sp/amp/ Inclusão! Professora ensina inglês virtualmente para pessoas trans - https://observatoriog.bol.uol.com.br/noticias/comportamento/inclusao-professora-ensina-ingles-virtualmente-para-pessoas-trans Nova série brasileira da Prime Video, “Lov3” terá protagonista gay - https://gay.blog.br/noticias/nova-serie-brasileira-da-prime-video-lov3-tera-protagonista-gay/ - TRANSEMPREGOS - https://www.transempregos.com.br/ - INSCRIÇÕES CURSO DE INGLÊS PARA PESSOAS TRANS: https://bityli.com/ndRGGA3 _________________________________________________ Alguma sugestão de pauta? Comentários? Indicações? Mande Mensagem de Voz no site do KILL, BIXA no Anchor: anchor.fm/killbixa Se quiser, mande um e-mail para killbixapod@gmail.com Siga nas redes: @kbpod no Instagram e no TikTok @bixakill no Twitter @gg_realoficial em todas as plataformas __________________________________________________ Um programa do Selo FIO | Rede Ativista de Vozes [Siga @fio.podcasts] Identidade Visual e Edição - Rod Gomes Pesquisa - Dan Pereira Roteiro - Dan Pereira e GG Apresentação e Produção Geral - GG ____________________________________________________________________________________________________ Não deixe de clicar em SEGUIR o podcast aí no seu player favorito e de ativar notificações para não perder nenhum episódio! Ah, e se compartilhar esse ou outros episódios, não deixe de nos marcar nas redes. ;)

Settimana molto fitta in cui a farla da padrone è stata la polemica legata a Kevin Porter jr e Wood. Inoltre sono usciti i primi risultati per l'ASG2022, con qualche sorpresa. Giddey entra nella storia NBA con un importante record e analizziamo i ritorno di Klay Thompson e di Kyrie Irving.

Si torna (finalmente) su Kamigawa! Piano che ci accoglie con una ambientazione decisamente diversa dal solito

Jiunn, Seth, John and Aaron discuss their review experience with the A.C.E. Prime Fiat Lux Insight https://developingpalates.com/reviews/cigar-reviews/team-cigar-review-a-c-e-prime-fiat-lux-insight/

Puntata di sabato 4 dicembre con il commento al terzo episodio di Hawkeye e tutte le principali uscite su Netflix, Disney+ e Prime Video tra cui The Witcher, Cobra Kai e The Book of Boba Fett

John and Aaron discuss their review experience with the A.C.E. Prime Luciano The Traveler https://developingpalates.com/reviews/cigar-reviews/team-cigar-review-a-c-e-prime-luciano-the-traveler/

Brevisssima pausa estiva di Landexplorer (solo 4 giorni!) e poi staremo assieme per Ferragosto con le nostre visite guidate che inizieranno venerdì 13 agosto e si concluderanno lunedì 16 agosto. sotto trovate i link per prenotarvi online!Venerdì 13 agosto - Nonio MiniExplorer: https://www.eventbrite.it/e/biglietti-nonio-miniexplorer-110607261296Sabato 14 agosto - Luzzogno ed i riti di luce: https://www.eventbrite.it/e/biglietti-luzzogno-gli-antichi-riti-di-luce-166050384169Domenica 15 agosto - Brolo: il paese dei gatti: https://www.eventbrite.it/e/biglietti-brolo-il-paese-dei-gatti-110585787066Lunedì 16 agosto - Oira ed il serpentino: https://www.eventbrite.it/e/biglietti-oira-ed-il-serpentino-166073625685Nel frattempo stiamo potenziando l'infrastruttura tecnologica, entro settembre ci sarà un nuovo sito ed una nuova newsletter oltre a 2 progetti che permetteranno ai giovani di mettersi in gioco e di conoscere in maniera più approfondita il territorio.Anche il videopodcast si rinnova nascerà "Cartoline dal Territorio" un video-podcast, settimanale o quindicinale, strutturato per raccontare il territorio del VCO (e non solo) con aneddoti, storia, memorie e tanto altro!

Join us for a refreshing, love-promoting, resilience-building episode 32 with Kerie-Ann 'Kiki' Thombs. Kiki Thombs is a Transformation Coach, Author, and Entrepreneur. Known for her charismatic personality both on and off the screen, Kiki has had a stellar career as a television and radio presenter, and producer. Kiki has a passion for helping others transform their lives and fulfills this passion through her company Self-Love JA. International. Her ability to persevere through life's challenges has deepened her resilience in every experience she encounters. Kiki has mastered the art of helping others heal from trauma. The release of her book, "Discovering You: The search is over", cements her lifelong practice of becoming the best version of herself and empowering others with neuroscience-based tools and spiritual practices that help them lead more fulfilling lives. In 2010 Kiki was the recipient for the Observer People's Choice award and winner of the Jamaica Broilers Fair Play awards for the documentary "Our very own locked up abroad" which she coproduced. As a television host she became a household name hosting entertainment programs such as Intense, Entertainment Report, and E-Prime and co-hosting Rising Stars and Weekend Smile. Kiki is also the Executive Producer for "Real Life" a show she also produces and co-hosts with her husband Denvo Thombs. The meaning behind her name K.I.K.I is Knowledge is key toward inspiration. In today's episode, Kiki shares snippets of her story and how she has discovered who she really is through a series of life-altering events, building her faith and doing the work to detox her brain and thoughts. She also shares these powerful gems: 1. It is important for us to heal mentally and emotionally, even as we build our faith: A broken Rasta man is still a broken Rasta man, likewise a broken Christian is still a broken Christian. Your faith alone (without doing the work) will not make you whole. You must listen to understand this principle. 2. The importance of renewing our minds and the scriptural evidence behind this. 3. Self-love is the prerequisite to becoming or doing anything great! 4. The importance of empowering people to see the value that lies inside of them. 5. Self-love is not self-care (it goes much deeper than that). Self-care is important and is more a mindset, than activities we engage in. Bonus: We must learn to love ourselves so the healing and growth can take place, and our true power can emerge. Thank you for listening! Please subscribe and share if you know someone who is looking for a dose of feel-good inspiration today!

Jiunn, Seth, John and Aaron discuss their review experience with the A.C.E. Prime M.X.S. Signature Adrián González El Titán https://developingpalates.com/reviews/cigar-reviews/team-cigar-review-a-c-e-prime-m-x-s-signature-adrian-gonzalez-el-titan/

Puntata di sabato 5 giugno nella quale abbiamo presentato le principali uscite del mese di giugno su Netflix, Prime Video e Disney+. Su molte di queste (Loki, Lupin e tante altre) ritorneremo nelle prossime puntate,

What is the goal of this podcast? How does a person become a polymath? What are the conceptual difficulties surrounding forgiveness? How can E-Prime help to highlight logical fallacies? How can we improve educational media?You can email Josh at jrc03c@pm.me.

What is the goal of this podcast? How does a person become a polymath? What are the conceptual difficulties surrounding forgiveness? How can E-Prime help to highlight logical fallacies? How can we improve educational media?You can email Josh at jrc03c@pm.me.[Read more]

Dr. Carolyn L.:                    Welcome to Circulation on the Run, your weekly podcast, summary, and backstage pass to the journal and its editors. I'm Dr. Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. On our podcast today we are discussing the role of diastolic stress testing and the evaluation of heart failure with preserved dejection fraction, a really hot topic indeed, but first here's your summary of this week's issue.                                                 The first study tackles the obesity paradox in cardiac surgery, where morbidity and mortality are lower in obese patients. This study sought to ask the question, "Is this due to reverse epidemiology, bias, or confounding?" To answer this question, Dr. Maris Kelko and colleagues from University Leicester in United Kingdom used two separate analysis. One, registry data from the National Adult Cardiac Surgery Registry and two, a systematic review in meta-analysis of studies. Of more than 400,000 patients in the cohort study and more than 550,000 patients in the systematic review, the authors found a U shape association between mortality and body mass index classes, where lower mortality was observed in overweight and obese class one and two patients, relative to normal weight patients, and mortality was increased in underweight individuals.                                                 Now, the obesity paradox has been attributed to reverse epidemiology where the survival benefit associated with obesity is thought to actually reflect worse outcomes in the underweight patients who also had frailty, cachexia, or severe chronic disease. However, in the current study, counter to the reverse epidemiology hypothesis, the protective effects of obesity were less in patients with chronic renal, lung, or cardiac disease and greater in older patients as well as in those with complications of obesity, such as metabolic syndrome and atherosclerosis. Furthermore, adjustments for important confounders did not alter the results. The authors therefore concluded that obesity is associated with lower risks after cardiac surgery with consistent effects noted in multiple analysis even after attempting to address residual confounding and reverse causation.                                                 The authors even went as far as to suggest that their findings do not support common practice where weight loss is recommended prior to surgery or where very obese patients are refused surgery in the morbidly obese. These provocative findings are discussed in an accompanying editorial by Doctor's Carnethon and Kahn from Northwestern University. While the editorialists agree that this well-designed study highlights an important knowledge gap, they pointed out that the obese class two patients had nearly five times greater risk for deep sternal wound infection and 25% higher likelihood of needing renal replacement therapy.                                                 In such patients additional intervention in the perioperative period may still be indicated and include weight loss recommendations and postoperative surveillance for complications. Thus, a more cautious final recommendation may be for future studies to prospectively assess weight loss interventions prior to elective surgery in the context of overall surgical risk as assessed by the EuroSCORE or STS models.                                                 The next paper describes mechanistic studies showing for the first time that nucleoside diphosphate kinase suppresses cyclic-AMP formation in human heart failure. In this paper by First Authors, Dr. Abu Taha and Hagemann, corresponding authors Dr.'s Tobref and Weilend from the Heidelberg University in Germany, the authors performed biochemical studies of nucleoside diphosphate kinase and G Protein signaling in human and rat tissue samples, assessed the functional impact of nucleoside diphosphate kinase C on cyclic-AMP levels and contractility and isolated red cardiomyocytes and determined that in vitro effects of these nucleoside diphosphate kinases on contractility in zebra, fish and mice.                                                 They identified nucleoside diphosphate kinase as the critical isoform for the regulation of G Protein function and cyclic-AMP levels in the heart with important consequences for cardiac contractility. The increased nucleoside diphosphate kinase membrane content in human heart failure could potentially counteract a fading beta adrenoceptor response in the early stages of heart failure by increasing the amount of G Alpha stimulatory proteins in the plasma membrane. However, by switching from stimulatory to G Alpha inhibitory to activation, nucleoside diphosphate kinase may play a role in heart failure progression by reducing cyclic-AMP levels, typical for end-stage human heart failure.                                                 The study, therefore contributes to a better understanding of the molecular processes, underlying alter G Protein signaling in heart failure, and may help to develop new heart failure therapies.                                                 The next study tested the hypothesis, that high intensity interval training is superior to moderate continuous training in reversing cardiac remodeling and increasing aerobic capacity in patients with heart failure and reduced ejection fraction.                                                 Doctor Ellingson and colleagues from the Norwegian University of Science and Technology, performed a multicenter trial, comparing twelve weeks of supervised interventions of high-intensity interval training at 90 to 95% maximal heart rate, moderate continuous training at 60 to 70% maximal heart rate, or a recommendation of regular exercise in 261 patients with heart failure and ejection fraction less than 35%, in New York Heart Association class II or III status.                                                 The primary end point of change in left ventricular end-diastolic diameter from baseline to twelve weeks was not different between the high-intensity and moderate continuous groups. There was also no difference between the high-intensity and moderate groups in peak oxygen uptake, although both were superior to the recommendation for regular exercise. None of these changes were maintained at follow up after 52 weeks. Serious adverse events were not statistically different. However, training records showed that 51% of patients exercised below the prescribed target, during supervised high-intensity interval training, and 80% above the recommended target in those with moderate continuous training. Given that high-intensity interval training was not superior to moderate continuous training, in reversing remodeling or improving secondary end points, and considering that adherence to the prescribed exercise intensity based on heart rate was difficult to achieve even in the supervised setting.                                                 The authors concluded that moderate continuous training remains the standard exercise modality for patients with chronic heart failure.                                                 The final paper tells us, that brain emboli after left ventricular endocardial ablation may be more common than we knew. First author Doctor Whitman, corresponding author Doctor Marcus and colleagues from University of California studied eighteen consecutive patients, scheduled for ventricular tachycardia or premature ventricular contraction ablation, over a nine month period. Twelve patients undergoing left ventricular ablation were compared to a control group of six patients, undergoing right ventricular ablation only. Heparin was administrated with a goal activated clotting time of 300 to 400 seconds for all left ventricular procedures. Pre impulse procedural brain magnetic resonance imaging was performed on each patient within a week of the ablation procedure. The authors found that seven of the twelve patients, or 58% undergoing left ventricular ablation, experienced a total of sixteen cerebral emboli, compared with none among patients undergoing right ventricular ablation. Seven of the eleven patients undergoing a retrograde approach to the left ventricle, developed at least one new brain lesion. Thus, more than half of patients undergoing routine left ventricular ablation procedures, experienced new brain emboli after the procedure, even in the absence of clinically apparent stroke.                                                 Future research is critical to understanding the long-term consequences of these lesions and to determine optimal strategies to avoid them. This is further discussed in an editorial entitled "The Sound of Silence". How much noise should we make about post ablation silence strokes? By Doctor Z and Vora from Stanford University. Well, those were your summaries, now for our featured discussion.                                                 I am so thrilled to have with me two special guests to discuss the topic of the diagnosis of heart failure preserved ejection fraction or HFpEF. As you all know, that's my favorite topic and I have favorite people with me today. First, the corresponding author of our feature paper, Doctor Barry Borlaug from Mayo Clinic, Rochester, Minnesota. And, for the first time on the podcast, Doctor Mark Drazner, Senior Associate Editor from UT Southwestern. So, welcome Barry and Mark. Barry Borlaug:                    Thank you Carolyn. Mark Drazner:                   Thank you, great to be here. Dr. Carolyn L.:                    So, Barry, you talked about the role of stress diastolic testing, shall I call it, in the  diagnosis of HFpEF in your paper. Could you tell us why you looked at it and what you found? Barry Borlaug:                    Sure, Carolyn. When you have dyspnea and fatigue and you got a low EF, it's pretty easy to make the diagnosis of heart failure reduced EF, but we've been struggling for years with making the diagnosis of dyspnea, whether it's HFpEF or not in people with normal ejection fraction. And that's because physical and laboratory and clinical signs of high filling pressures and congestion, are either difficult to see or only present during stress, like physical exercise, in patients. So that's really what motivated us to pursue this study.                                                 We took patients, that were referred to our cath lab for invasive hemodynamic exercise testing, so we directly measured filling pressures, PA pressures and cardiac output reserve, to get a gold standard assessment, whether people have heart failure or not. And then we performed simultaneous echocardiography and blood testing to measure NT-proBNP levels, and then we just looked at what we could figure out. Can you accurately discern HFpEF patients from patients without cardiac dyspnea, using these non invasive estimates.                                                 We saw that a lot of people, with, for example, NT-proBNP levels that are low enough to be where most would consider HFpEF excluded, actually had HFpEF. And we saw that there were modest correlations between non-invasive echocardiographic estimates of filling pressures, specifically the E to E Prime ratio, and directly measured left heart filling pressures. But when we applied the criteria that had been initially proposed, we saw poor sensitivity to make the diagnosis with exercise. And this was largely related to the difficulty with getting all of the different echocardiographic indices, that are currently examined as part of the diastolic stress testing non-invasively. Next, we looked at just adding the exercise E to E Prime, which is an estimate of filling pressures, and when we used the cut-point, that's already been proposed, according to contemporary data, we found that this substantially improved the sensitivity to identify HFpEF, but there was a bit of a trade-off in that specificity decrease. Dr. Carolyn L.:                    That's so cool. So let me summarize some of these take-home messages here. First of all, using just rest echo. I was really impressed to see that rest echo indices alone only identifies a third to maybe up to 60% of the patients you found with invasively proven HFpEF. So, we may be specific, but we're really missing quite a number of patients. And then if you exercise them, what your data is really showing is that it's better to exercise them and use this data for the negative predictive value, isn't that what you're saying? Barry Borlaug:                    You know, the exercise is really the gold standard, so it gives you both, the negative and positive. With the echocardiography, relying on the exercise E to E Prime ratio, that was really helping us, as you say, Carolyn, with the higher negative predictive value. So most people, that had HFpEF, in this series, where we could get adequate, highly controlled environments, adequate diagnostic echocardiographic data, most people that ended up having HFpEF fit those criteria, we could see an elevation in this E to E Prime on exercise, so it did provide good negative predictive value. Dr. Carolyn L.:                    These are just such important data, because I think we're all still struggling with how to make this diagnosis of HFpEF. Mark, could you just share some thoughts on whether you think this is going to really change practice, even change guidelines? Mark Drazner:                   I think, if you read this paper, you would recognize it, that it's certainly a critical question that we're all facing, how to make the diagnosis of HFpEF. And all of their guidelines that have been advocated, there really wasn't much data, and these really are the best data out there. So, certainly, it's [inaudible 00:15:41] me a direction of changing practices. Barry says, certainly, the approach will need to be validated, I think, before it reaches high level guidelines, but certainly I think it's a step in the right direction, and points the way towards the future in terms of improving our ability to diagnose HFpEF. And really, that's why both reviewers and [inaudible 00:15:59] this is such an important paper. Dr. Carolyn L.:                    Right. Barry, I have a quick question for you though. Doing exercise echo, not easy. E to E Primes are all over the place usually. How easy was it? How feasible was this test? Barry Borlaug:                    So, first I'd like to say that we have outstanding, very well-trained, very highly skilled research scenographers, here at Mayo doing this. In very controlled environment, we're providing plenty of time for them to obtain images and that's going to be a question moving forward, because not everybody in clinical practice has that capability. But with that said, in this very controlled environments, skilled scenographers, we were able to measure the exercise data during low level exercise about 85 to 90% of the time and at peak exercise about 75 to 80% of the time. So, it's fairly feasible, but even in this best case scenario, we can't get it on everybody. Mark Drazner:                   Even in the [inaudible 00:19:49] echo lab, the recommended approach by the ASE with the four measures. How many times they were not able to acquire all those images, are necessary for those four techniques and so, here you have a [inaudible 00:20:03] of AS echo lab not being able to do that, and being transparent about that, and [inaudible 00:20:08] to the community, saying that, although these are ideal measures, even the [inaudible 00:20:12] perhaps you can't acquire them. I think that was another important point that came out of this and then lead to the focus on the E to E Prime. Barry Borlaug:                    I couldn't agree more. You got one of the world renowned labs, very skilled scenographers doing imaging, and we're still not able to get it all in each patient, and that just points to the difficulty of getting really high quality diagnostic images, and a lot of time you need the next level test, when that happens. And invasive exercise testing is really that test, the gold standard. Mark Drazner:                   When you get echos from the outside and you look at the E to E Primes, are you confident that the data, that's generally acquired, is gonna be acceptable for this [inaudible 00:20:50]? Barry Borlaug:                    Yes and no, I mean I'm always a little bit concerned, but it's not just being a control freak, you know, wanting to see everything, but I think that if it's a still frame doppler, tissue doppler spectrum, you can see that the sample volume is in the right place, and it's really unequivocally normal or abnormal, I feel pretty good about that. Not as good as when they get a full dedicated study here. Mark Drazner:                   Of course, the gold standard is also difficult. The invasive measurement. Barry Borlaug:                    Yes it is, I didn't [inaudible 00:21:18] that, but we've been doing a lot of invasive exercise tests for the last ten years now. And we do like 250 a year here, so we're really quite [inaudible 00:21:28] but we have all hands on deck in the lab. We have a couple technicians running gas samples around, all over the place. Somebody is on the medgraphics card, measuring oxygen consumption. We've got a nurse in there, that's helping out, so it's complicated, and of course we're using the micromanometer catheters for the pressure assessments, because you get so much more artifacts from width and under damping and over damping with the pressure tracing, so that's also not easy to do if you say. Mark Drazner:                   So maybe for practicing cardiologists it's gonna be hard to duplicate that and perhaps spend the energy in terms of doing the exercise echo techniques off the speed, for example. Perhaps, it's another message. Barry Borlaug:                    I would agree completely. And I think that again, when you do that, if you do a really high quality exercise echo and it's still not quite definitive, then you can refer on to a center that does have that capability, because obviously it's just reality, not everybody is going to be able to do this. Not every place has the size and resources to be able to do these really advanced tasks.   Dr. Carolyn L.:                    And do you apply exercise echo now in making your diagnosis? How do you use this data, for yourself, clinically? Barry Borlaug:                    We started to think about this, and I think that the best case scenario where the  people, that really have an intermediate pretest probability, based on their clinical characteristics. Somebody has jugular distension and a very high NT-proBNP level, and edema, you really don't need further testing, you know that that's going to be HFpEF. And if somebody has no risk factors, and everything is stone cold normal, they don't.                                                 But in some of these people that have some signals, but they don't quite meet criteria, we are doing this, again, if they have adequate echocardiographic images at rest. And then we're looking really carefully at the exercise echocardiography data, one concern from this data, I want to make sure people are very circumspect and really critically looking at the quality of their data, because we shouldn't over-interpret equivocal findings. And as you said earlier, E to E Primes can be all over the map, they're very difficult to obtain during exercise. But I think that if everything looks very high quality and is definitely abnormal or definitely normal, that can be helpful. More so, if it's normal. We     did see more false positive, so if it is abnormal, we did suggest that you may want to perform further confirmatory testing, because of the higher false positive rate with exercise echo. Mark Drazner:                                                                   I would say for the listeners, they should take a look at his figure six, which really is a nice diagnostic algorithm, where Barry shows, or advocates, for taking patients with intermediate probability and then using this to restratify that, using [inaudible 00:19:40] approach. I know that, that figure resonated with the editors and the reviewers dramatically, so I'd encourage listeners to take a look at that. Dr. Carolyn L.:                    Listeners, you heard it right. [inaudible 00:22:36] Circulation on the Run. Don't forget to tell all your friends about this podcast and tune in next week.  

I am happy to introduce, Daniel Waterman. He is a philosopher, artist, writer, and Ayahuasca provider based in the Netherlands. He is also the author of Entheogens, Society & Law. Daniel and I met up in the Netherlands to record this conversation in his living room. The recording taps into the conversation just as Daniel begins to speak about the implications of a major turning point in his journey with Ayahuasca just after 9/11 terrorist attacks in 2001. Daniel carries the conversation in poignant and poetic forms from there as we touch on the larger context around his book Entheogens, Society & Law, death and rebirth, religious morals and ethics and their place in law, DMT entities and 'Meaning', E-Prime, and what it means to find relevant questions. This is a beautiful journey with a very well-spoken and insightful man who has a lot to offer us. Enjoy. (ep. originally titled "Entheogens, Society & Law") Full Show Notes: http://bit.ly/ATTMindRadioEp36 Support The Podcast PayPal Donation Patreon Other Options (including bitcoin)

Prepare for a deep exploration Of partnership and conversation, Surrender and tears, Attraction and fears: What we did on our spiritual staycation. Part 2 of what we learned on our spiritual staycation: “my life”, E-Prime, the Sapir-Whorf hypothesis, spiritual partnership, and our biggest takeaway from our spiritual staycation. (Hint: It has to do with Seafarers […]