Podcasts about clinical relevance

Okay, this might sound like a trick question, but…What is dysphagia? This single question might be the most “swallow your pride” kind of question for medical SLPs yet… Because, believe it or not, we have yet to establish a standardized definition of dysphagia! Which is exactly why Martin B. Brodsky Ph.D., Sc.M., CCC-SLP, F-ASHA, and Debra Suiter PhD, CCC-SLP, BCS-S are putting together a conference called “Defining Dysphagia: In Search of a Unified Definition for the Aging Population” and are joining me on this week's episode of the Swallow Your Pride Podcast to talk about it! Dr. Brodksy and Dr. Suiter lay out the facts, questions, and barriers surrounding dysphagia definitions and how they impact clinical practice, research, and patient care. From the discrepancies between patient complaints and clinical definitions to the impacts that dysphagia has on coding and reimbursement, this single word has yet to reach a universal interpretation. The Defining Dysphagia conference is happening September 13th - 15th, and you can register now at https://syppodcast.com/definingdysphagia Timestamps:   Importance of Consensus Definition (00:28:32) Speaker Lineup for Saturday (00:30:58) Telehealth in Dysphagia Treatment (00:31:09) Neurodegenerative Diseases Focus (00:32:12) Clinical Relevance of Speakers (00:33:30) Speakers' Role in Delphi Process (00:34:12) Conference Structure and CEUs (00:36:35) Multidisciplinary Nature of Conference (00:39:14) Invitation to Attend (00:40:36) Conference Website Information (00:41:16) The post 337 – That's Not What Dysphagia Means: The Search for a Standardized Definition of One of the Most Important Words in Our Field. appeared first on Swallow Your Pride Podcast.

Join Drs. Yuan and Callahan as they continue their discussion on HER2+ testing by reviewing our current understanding of HER2+ low and how it differs from HER2+ and HER2 negative. They explore the role of neoadjuvant therapy in HER2+ patients, post-operative phenotype shifts, and the need for HER2+ testing after surgery. They share cases from their practices where these issues arose and discuss how clinicians should approach post-treatment testing, including the concept of microtumor residual disease. Additionally, they examine precision medicine's role in improved HER2+ testing, including the potential of AI to enhance testing accuracy. Finally, they discuss the distinctions between HER2 low and HER2 ultralow.

Drs. Yuan and Callahan discuss HER2 testing in breast cancer. They will explore the clinical relevance and need for testing, and discuss testing methods, evolving testing guidelines, and interpretation of results.

María-Victoria Mateos, MD, PhD - Updates in Multiple Myeloma From Madrid: Data Surrounding BCMA-Directed Agents and Their Clinical Relevance

María-Victoria Mateos, MD, PhD - Updates in Multiple Myeloma From Madrid: Data Surrounding BCMA-Directed Agents and Their Clinical Relevance

María-Victoria Mateos, MD, PhD - Updates in Multiple Myeloma From Madrid: Data Surrounding BCMA-Directed Agents and Their Clinical Relevance

María-Victoria Mateos, MD, PhD - Updates in Multiple Myeloma From Madrid: Data Surrounding BCMA-Directed Agents and Their Clinical Relevance

Professors Wytske Fokkens and Joaquim Mullol discuss the burden of smell loss and the emerging science on how inflammation drives olfactory dysfunction in patients with CRSwNP. ADVENT is a medical education non-promotional resource for healthcare professionals organized by Sanofi and Regeneron. Learn more at ADVENTprogram.com. This podcast is intended for healthcare professionals only. Disclaimer:  This program is non-promotional and is sponsored by Sanofi and Regeneron Pharmaceuticals, Inc. The speakers are being compensated and/or receiving an honorarium from Sanofi and Regeneron in connection with this program The content contained in this program was jointly developed by the speakers and Sanofi and Regeneron and is not eligible for continuing medical education (CME) credits Speaker disclosures: Professor Wytske Fokkens, MD, PhD has received consultation/speaker fees from Novartis, Sanofi, GSK and Dianosic.  Professor Joaquim Mullol, MD, PhD reports have received research grants, participated in clinical trials, been a member of Speaking Bureaus and Advisory Boards from Allakos, AstraZeneca, Glenmark, GSK, Menarini, MSD, Mitsubishi-Tanabe, Noucour/Uriach Group, Novartis, Optinose, Proctor & Gamble, Sanofi-Genzyme, Regeneron Pharmaceuticals, Viatris. © 2024 Sanofi and Regeneron Pharmaceuticals, Inc. All Rights Reserved. MAT-GLB-2400013 v1.0 01/2024 MAT-US-24000221 v1.0 - P Expiration Date: 01/08/2026

Click to know more about Easy Ayurveda Hospitalhttps://www.easyayurveda.com/hospital/Buy our new course on Marma Therapyhttps://www.easyayurveda.com/marma1Subscribe to Easy Ayurveda Video Classes https://www.easyayurveda.com/video-classes/Subscribe to our free Easy Ayurveda newsletter here (you can unsubscribe and stop them anytime) -  https://forms.aweber.com/form/58/2129766958.htm Buy our course on diabetes reversal, powered by Madhavbaug https://www.easyayurveda.com/diabetes Buy our online video course on Treatment of cardiac disorders with Ayurveda https://www.easyayurveda.com/heartMaster ECG in one week. Sign up for video course https://www.easyayurveda.com/ecgContact Dr. MB Gururaja BAMS MD (Ayu)https://www.easyayurveda.com/gururaja  Contact Dr. Raghuram YS BAMS MD (Ayu)https://www.easyayurveda.com/raghuram Buy Easy Ayurveda Ebooks https://www.easyayurveda.com/my-book Buy Easy Ayurveda Printed Books https://www.easyayurveda.com/books/

In this insightful episode of the Global Medical Device Podcast, host Etienne Nichols engages with Carmen Brown, the regulatory and quality affairs manager at Proxima Clinical Research. They delve into the specifics of In Vitro Diagnostics (IVDs) and explore the challenges and considerations faced by medical device manufacturers in the IVD pathway. Whether you're an industry veteran or new to the field of medical diagnostics, this conversation will enlighten you about the nuances of IVD regulatory compliance, risk assessment, and FDA interactions.Episode Highlights:IVDs are a Specialized Medical Device: Learn how IVDs, which include reagents, instruments, or systems for diagnosis, differ from other medical devices and what specific regulatory pathways they follow.Risk Levels in IVDs: Understand the significance of classifying IVDs into class one, two, or three based on the risk of false or inaccurate results, and how this impacts regulatory strategy.Pitfalls in Performance Characteristic Evaluation: Discover the complexities involved in evaluating the performance of multiband diagnostics and why traditional measures like sensitivity and specificity may not suffice.Likelihood Ratios Over Sensitivity and Specificity: Grasp why likelihood ratios are a more appropriate statistical measure for multiband diagnostics and how they relate to pretest and posttest probabilities.Clinical Relevance is Key: Recognize the importance of ensuring that the markers detected by IVDs are clinically meaningful and relevant to the condition being diagnosed.FDA's Expectations for IVDs: Gain insights into the specific data and performance characteristics the FDA looks for in IVDs and the necessity of clinical data in regulatory submissions.Quote:"With IVDs, you're looking at it from the perspective of what's the risk of a false result or an inaccurate result. So you're looking at who's interpreting the results and the type of condition." ~Carmen BrownReference Links:Carmen BrownProxima Clinical ResearchGreenlight GuruEtienne Nichols' LinkedIn*Interested in sponsoring an episode? Use this form and let us know!

In this week's episode, Adrienne guides you through a Yoga Nidra Meditation inspired by last week's guest, Amanda. If you haven't listened to episode 39 yet, what are you waiting for?!Yoga Nidra or "yogic sleep" is a state of consciousness between waking and sleeping. Clinical studies have shown that Yoga Nidra meditation is associated with positive physiological changes, including improvements in several hematological variables, red blood cell counts, blood glucose levels, and hormonal status. In fact, one hour of Yoga Nidra equates to roughly 4 hours of deep REM sleep! Last week, Amanda opened up about how her "hot tears" in savasana had her coming back to her mat over and over again.  Now, Amanda is a beloved, full time Yoga teacher, where she specializes in serving people in various rehabilitation and mental health facilities throughout SATX. Wanna learn more, check out the below links for reference information on Yoga Nidra. National Library of Medicine on The Origin and Clinical Relevance of Yoga NidraYogaInternational.com What Is Yoga Nidra & Its Benefits Follow us on TikTok:https://www.tiktok.com/@yogachangedFollow us on Instagram:https://instagram.com/yogachanged?igshid=YmMyMTA2M2Y=For more, go to https://howyogachangedmylife.com Wanna be on the show? Click here to fill out our guest info form or drop us a email at yogachanged@gmail.com

Host Roz is joined by Ramsey Hachem, MD (Washington University School of Medicine in Saint Louis) and AJT Editorial Fellow Helen Tsai, MD (Montefiore Medical Center)  [03:30] Disseminated vaccine-induced varicella infection in a kidney transplant recipient [06:50] Safety and Immunogenicity of the Live-Attenuated Varicella Vaccine in Pediatric Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis [10:34] (Editorial) Balancing the live virus vaccine scales: protection vs risk [14:22] Outcomes after flow cytometry crossmatch-positive lung transplants managed with perioperative desensitization [19:25] Lung transplantation despite preformed donor-specific anti-HLA antibodies: 9-year single-center experience [23:00] (Editorial) What is a Clinically Significant Donor-Specific Antibody Before Lung Transplantation? [25:38] Deceased Donor Kidneys from Higher Distressed Communities are Significantly Less Likely to be Utilized for Transplantation [35:11] (Editorial) Understanding the mechanisms and implications of the association between community distress and organ non-utilization [37:18] Sex as a Biological Variable: Mechanistic Insights and Clinical Relevance in Solid Organ Transplantation

DrBeen#50 Omega-3 and Exercise for Brain Health Continuing with our series about brain health and lifestyle choices, today we will discuss omega-3 fish oil and exercise. Omega-3 fish oil or omega-3 polyunsaturated fatty acids (n3-PUFA) have a rich presence in our brain tissue. n3-PUFA helps keep astrocyte from becoming activated. Hence, it reduces inflammation in the brain and also keeps aquaporin 4 (AQP4) channels polarized and on the foot processes of the astrocytes. The result is a better glymphatic flow, which washes away more beta amyloids and helps protect or stall the progress of dementia. DrBeen: Medical Education Onlinehttps://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/ URL list from Monday, Mar. 23 2023 The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/ Sleep well — and reduce your risk of dementia and death - Harvard Healthhttps://www.health.harvard.edu/blog/sleep-well-and-reduce-your-risk-of-dementia-and-death-2021050322508 APOE ε4, Alzheimer's disease neuropathology and sleep disturbance, in individuals with and without dementia | Alzheimer's Research & Therapy | Full Texthttps://alzres.biomedcentral.com/articles/10.1186/s13195-022-00992-y N3 Phase of Sleep.https://chat.openai.com/chat Understanding Delta Brain Waves And Sleephttps://www.sixstepstosleep.com/understanding-delta-brain-waves/ N3: Slow Wave Sleep | Sleepopolishttps://sleepopolis.com/education/n3-slow-wave-sleep/ Stage N3 of sleep. Delta waves on EEG recordings are observed.  | Download Scientific Diagramhttps://www.researchgate.net/figure/Stage-N3-of-sleep-Delta-waves-on-EEG-recordings-are-observed_fig4_280558638 A 30-second Epoch consisting of the parameters of staging sleep... | Download Scientific Diagramhttps://www.researchgate.net/figure/4-A-30-second-Epoch-consisting-of-the-parameters-of-staging-sleep-electroencephalogram_fig4_282014972 Hallmark of Stage N3 (slow-wave sleep or Stages 3 and 4 sleep: delta... | Download Scientific Diagramhttps://www.researchgate.net/figure/Hallmark-of-Stage-N3-slow-wave-sleep-or-Stages-3-and-4-sleep-delta-waves_fig1_5812861 Frontiers | Perivascular Spaces, Glymphatic System and MRhttps://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLinkhttps://link.springer.com/article/10.1007/s00234-021-02718-7 Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous Systemhttps://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full Neuroglia Lab : Glymphatics and virchow-robin spacehttp://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurologyhttps://n.neurology.org/content/98/3/107 Aquaporin-4 - Wikipediahttps://en.wikipedia.org/wiki/Aquaporin-4 Astrocyte - Wikipediahttps://en.wikipedia.org/wiki/Astrocyte Neurocytology-Astrocyteshttps://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS. Blood-brain barrier | RIThttps://www.rit.edu/spotlights/blood-brain-barrier The Blood-Brain Barrier | Morphology of Nervous Systemhttps://sisu.ut.ee/histology/blood-brain-barrier Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier | Fluids and Barriers of the CNS | Full Texthttps://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-018-0113-6 Disclaimer:As previous

DrBeen#46 Intermittent Fasting and Brain Health Intermittent fasting causes production of beta hydroxybutarate, which in turn helps improve the glymphatic flow of fluids in the brain. This in turn leads to a better clearance of waste products from the brain, helping to improve the cognitive state, memory, and potentially stall the progress of dementia. DrBeen: Medical Education Onlinehttps://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/ URL list from Friday, Feb. 17 2023 19:11 PM The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/ Frontiers | Perivascular Spaces, Glymphatic System and MRhttps://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLinkhttps://link.springer.com/article/10.1007/s00234-021-02718-7 Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous Systemhttps://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full Neuroglia Lab : Glymphatics and virchow-robin spacehttp://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurologyhttps://n.neurology.org/content/98/3/107 Aquaporin-4 - Wikipediahttps://en.wikipedia.org/wiki/Aquaporin-4 Astrocyte - Wikipediahttps://en.wikipedia.org/wiki/Astrocyte Neurocytology-Astrocyteshttps://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS. Blood-brain barrier | RIThttps://www.rit.edu/spotlights/blood-brain-barrier The Blood-Brain Barrier | Morphology of Nervous Systemhttps://sisu.ut.ee/histology/blood-brain-barrier Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier | Fluids and Barriers of the CNS | Full Texthttps://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-018-0113-6 The glymphatic systems in the brain and the eye export fluid and... | Download Scientific Diagramhttps://www.researchgate.net/figure/The-glymphatic-systems-in-the-brain-and-the-eye-export-fluid-and-solutes-from_fig1_353240231 External Carotid Artery: Anatomy & Branches | Study.comhttps://study.com/academy/lesson/external-carotid-artery-anatomy-branches.html Cervical Node Mets fron Occult Primaryhttp://www.aboutcancer.com/cervical_node_occult_utd_907.htm Donate to the Front Line Covid-19 Critical Care Alliance, Inc. 
To educate medical professionals and the public in safe and effective ways to prevent and treat COVID-19. Click here to make a donation:https://frontlinecovid-19criticalcarealliance.salsalabs.org/donate/index.html Buy FLCCC gear: https://supportflccc.store/ Subscribe to our mailing list on our website: http://flccc.net/signup Disclaimer:This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

DrBeen#47 Role of The Glymphatic System in Sleep and Brain Health N3 Sleep, Glymphatic System, and Brain Health N3 phase of the sleep is characterised by delta waves, also called slow wave sleep (SWS). This is the most restorative phase of the sleep. An important part of this phase is the increase in the glymphatic convection in the brain leading to clearance of the waste products. Let's review. DrBeen: Medical Education Onlinehttps://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/ URL list from Monday, Feb. 20 2023 The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/ N3 Phase of Sleep.https://chat.openai.com/chat Understanding Delta Brain Waves And Sleephttps://www.sixstepstosleep.com/understanding-delta-brain-waves/ N3: Slow Wave Sleep | Sleepopolishttps://sleepopolis.com/education/n3-slow-wave-sleep/ Stage N3 of sleep. Delta waves on EEG recordings are observed.  | Download Scientific Diagramhttps://www.researchgate.net/figure/Stage-N3-of-sleep-Delta-waves-on-EEG-recordings-are-observed_fig4_280558638 A 30-second Epoch consisting of the parameters of staging sleep... | Download Scientific Diagramhttps://www.researchgate.net/figure/4-A-30-second-Epoch-consisting-of-the-parameters-of-staging-sleep-electroencephalogram_fig4_282014972 Hallmark of Stage N3 (slow-wave sleep or Stages 3 and 4 sleep: delta... | Download Scientific Diagramhttps://www.researchgate.net/figure/Hallmark-of-Stage-N3-slow-wave-sleep-or-Stages-3-and-4-sleep-delta-waves_fig1_5812861 Frontiers | Perivascular Spaces, Glymphatic System and MRhttps://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLinkhttps://link.springer.com/article/10.1007/s00234-021-02718-7 Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous Systemhttps://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full Neuroglia Lab : Glymphatics and virchow-robin spacehttp://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurologyhttps://n.neurology.org/content/98/3/107 Aquaporin-4 - Wikipediahttps://en.wikipedia.org/wiki/Aquaporin-4 Astrocyte - Wikipediahttps://en.wikipedia.org/wiki/Astrocyte Neurocytology-Astrocyteshttps://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS. Blood-brain barrier | RIThttps://www.rit.edu/spotlights/blood-brain-barrier The Blood-Brain Barrier | Morphology of Nervous Systemhttps://sisu.ut.ee/histology/blood-brain-barrier Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier | Fluids and Barriers of the CNS | Full Texthttps://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-018-0113-6 The glymphatic systems in the brain and the eye export fluid and... | Download Scientific Diagramhttps://www.researchgate.net/figure/The-glymphatic-systems-in-the-brain-and-the-eye-export-fluid-and-solutes-from_fig1_353240231 External Carotid Artery: Anatomy & Branches | Study.comhttps://study.com/academy/lesson/external-carotid-artery-anatomy-branches.html Cervical Node Mets fron Occult Primaryhttp://www.aboutcancer.com/cervical_node_occult_utd_907.htmep 46 Buy FLCCC gear: https://supportflccc.store/ Subscribe to our mailing list on our website: http://flccc.net/signup Disclaimer:As per others

DrBeen#48 Alzheimer's, Sleep Disturbance, and Brain Health Studies present an association between APOE4 and sleep disturbance. Additionally APOE4 is linked to sleep disturbance before the onset of Alzheimer's symptoms. In ‘The Sleeping Brain' article (see below) the authors suggest that sleep disturbance causes reduced removal of the waste products from the brain, leading to the accumulation of beta amyloids - which in turn is observed in Alzheimer's disease. Additionally, it is thought that APOE directly leads to beta amyloid metabolism disturbance. And, finally, it is thought that stress-related proteolytic cleavage of APOE4 leads to accumulation of tau proteins. Let's review the evidence. DrBeen: Medical Education Onlinehttps://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/ URL list from Monday, Feb. 20 2023 The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/ Sleep well — and reduce your risk of dementia and death - Harvard Healthhttps://www.health.harvard.edu/blog/sleep-well-and-reduce-your-risk-of-dementia-and-death-2021050322508 APOE ε4, Alzheimer's disease neuropathology and sleep disturbance, in individuals with and without dementia | Alzheimer's Research & Therapy | Full Texthttps://alzres.biomedcentral.com/articles/10.1186/s13195-022-00992-y N3 Phase of Sleep.https://chat.openai.com/chat Understanding Delta Brain Waves And Sleephttps://www.sixstepstosleep.com/understanding-delta-brain-waves/ N3: Slow Wave Sleep | Sleepopolishttps://sleepopolis.com/education/n3-slow-wave-sleep/ Stage N3 of sleep. Delta waves on EEG recordings are observed.  | Download Scientific Diagramhttps://www.researchgate.net/figure/Stage-N3-of-sleep-Delta-waves-on-EEG-recordings-are-observed_fig4_280558638 A 30-second Epoch consisting of the parameters of staging sleep... | Download Scientific Diagramhttps://www.researchgate.net/figure/4-A-30-second-Epoch-consisting-of-the-parameters-of-staging-sleep-electroencephalogram_fig4_282014972 Hallmark of Stage N3 (slow-wave sleep or Stages 3 and 4 sleep: delta... | Download Scientific Diagramhttps://www.researchgate.net/figure/Hallmark-of-Stage-N3-slow-wave-sleep-or-Stages-3-and-4-sleep-delta-waves_fig1_5812861 Frontiers | Perivascular Spaces, Glymphatic System and MRhttps://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLinkhttps://link.springer.com/article/10.1007/s00234-021-02718-7 Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous Systemhttps://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full Neuroglia Lab : Glymphatics and virchow-robin spacehttp://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurologyhttps://n.neurology.org/content/98/3/107 Aquaporin-4 - Wikipediahttps://en.wikipedia.org/wiki/Aquaporin-4 Astrocyte - Wikipediahttps://en.wikipedia.org/wiki/Astrocyte Neurocytology-Astrocyteshttps://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS. Donate to the Front Line Covid-19 Critical Care Alliance, Inc.https://frontlinecovid-19criticalcarealliance.salsalabs.org/donate/index.html Subscribe to our mailing list on our website: http://flccc.net/signup Disclaimer:As per others

DrBeen#49 Norepinephrine, Glymphatic System, and Brain Health During the wakeful hours, the production of norepinephrine increases. This increase helps with alertness, but also causes vasoconstriction. The outcome is a reduction in the interstitial fluid levels and reduction in the clearance of waste products. During sleep, NE levels reduce, reversing the above mentioned mechanisms, leading to more interstitial fluid movement and more glymphatic clearance of the waste products and better brain health. DrBeen: Medical Education Onlinehttps://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/ URL list from Monday, Feb. 20 2023 The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/ Norepinephrine: What It Is, Function, Deficiency & Side Effectshttps://my.clevelandclinic.org/health/articles/22610-norepinephrine-noradrenaline#:~:text=What%20does%20norepinephrine%20do%20in,pressure%20in%20times%20of%20stress. Frontiers | Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targetshttps://www.frontiersin.org/articles/10.3389/fncir.2021.638007/full#:~:text=The%20locus%20coeruleus%20(LC)%2C,%2C%20cerebellum%2C%20and%20spinal%20cord. fncir-15-638007-g001.jpg (1700×984)https://www.frontiersin.org/files/Articles/638007/fncir-15-638007-HTML/image_m/fncir-15-638007-g001.jpg Sleep well — and reduce your risk of dementia and death - Harvard Healthhttps://www.health.harvard.edu/blog/sleep-well-and-reduce-your-risk-of-dementia-and-death-2021050322508 APOE ε4, Alzheimer's disease neuropathology and sleep disturbance, in individuals with and without dementia | Alzheimer's Research & Therapy | Full Texthttps://alzres.biomedcentral.com/articles/10.1186/s13195-022-00992-y N3 Phase of Sleep.https://chat.openai.com/chat Understanding Delta Brain Waves And Sleephttps://www.sixstepstosleep.com/understanding-delta-brain-waves/ N3: Slow Wave Sleep | Sleepopolishttps://sleepopolis.com/education/n3-slow-wave-sleep/ Stage N3 of sleep. Delta waves on EEG recordings are observed.  | Download Scientific Diagramhttps://www.researchgate.net/figure/Stage-N3-of-sleep-Delta-waves-on-EEG-recordings-are-observed_fig4_280558638 A 30-second Epoch consisting of the parameters of staging sleep... | Download Scientific Diagramhttps://www.researchgate.net/figure/4-A-30-second-Epoch-consisting-of-the-parameters-of-staging-sleep-electroencephalogram_fig4_282014972 Hallmark of Stage N3 (slow-wave sleep or Stages 3 and 4 sleep: delta... | Download Scientific Diagramhttps://www.researchgate.net/figure/Hallmark-of-Stage-N3-slow-wave-sleep-or-Stages-3-and-4-sleep-delta-waves_fig1_5812861 Frontiers | Perivascular Spaces, Glymphatic System and MRhttps://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLinkhttps://link.springer.com/article/10.1007/s00234-021-02718-7 Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous Systemhttps://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full Neuroglia Lab : Glymphatics and virchow-robin spacehttp://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurologyhttps://n.neurology.org/content/98/3/107 Aquaporin-4 - Wikipediahttps://en.wikipedia.org/wiki/Aquaporin-4 Astrocyte - Wikipediahttps://en.wikipedia.org/wiki/Astrocyte Neurocytology-Astrocyteshttps://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS. Disclaimer As per previous episodes

Marco Burkhard, MD of Balgrist University Hospital in Switzerland discusses his recent NASSJ article "Clinical relevance of occult infections in spinal pseudarthrosis revision" with moderator and NASSJ deputy editor Tobias Mattei, MD.

In this episode of the Award-winning PRS Journal Club Podcast, 2022 Resident Ambassadors to the PRS Editorial Board – Saïd Azoury, Emily Long, and Ronnie Shammas- and special guest Brett T. Phillips, MD, discuss the following articles from the November 2022 issue: “Clinical Relevance of Sensory Nerve Coaptation in DIEP Flap Breast Reconstruction Evaluated Using the BREAST-Q” by Bijkerk, Buegels, van Kujik et al. Read the article for FREE: https://bit.ly/NerveCoapatationDIEP Special guest Brett T. Philips, MD, is an Assistant Professor and Program Director at Duke Integrated Plastic Surgery Program. He completed his General Surgery training at the State University Of New York At Stony Brook, Plastic Surgery training at Duke University, and Microvascular training at MD Anderson. He is the new Chair of the Young Microsurgeons Group Committee. READ the articles discussed in this podcast as well as free related content from the archives: https://bit.ly/PRSNov22Collection

Get CE off your to-do list! Start earning your CE credits today at https://rdh.tv/ce Refresher on Different Types of Scientific Studies and Their Clinical Relevance By Spring Hatfield, RDH Original article published on Today's RDH: https://www.todaysrdh.com/refresher-on-different-types-of-scientific-studies-and-their-clinical-relevance/ Get daily dental hygiene articles at https://www.todaysrdh.com Follow Today's RDH on Facebook: https://www.facebook.com/TodaysRDH/ Follow Kara RDH on Facebook: https://www.facebook.com/DentalHygieneKaraRDH/ Follow Kara RDH on Instagram: https://www.instagram.com/kara_rdh/

Recirculation Measurement by ELSA Monitor for VV ECMO Patients (Methodology and Clinical Relevance). Presented by Nikolai Krivitski PhD, DSc.

Our October episode features Dr. Darren Brenner from Northwestern University and a member of the committee who recently co-authored the 2020 ACG Guidelines for IBS Management. We review the key recommendations and some of the changes to the universal guidelines as well as what they mean for clinical practice for both providers and for patients.

An individual, who is overweight or obese, with a dysfunctional lipid pattern, especially triglycerides, a blood fat elevated from excessive consumption of simple carbohydrates and saturated fats (fast food), may be at greater risk to postprandial (after a meal) hypertriglyceridemia (elevated triglycerides). According to "Clinical Relevance of Non-Fasting and Postprandial Hypertriglyceridemia and Remnant Cholesterol," which appeared in 2011 on PubMed.gov, “non-fasting triglycerides are measured at any time within up to 8 hours, after any normal meal, while postprandial triglycerides are measured at a fixed time point within up to 8 hours of a standardized fat tolerance test.”“In the general population, 38% of men have non-fasting/postprandial triglycerides > 2mmol/L (>176 mg/dL), while 45% of men have non-fasting/postprandial triglyceride levels of 1-2 mmol/L (89-176 mg/dL); corresponding fractions in women are 20% and 47%,” notes the study authors from the Human Performance Laboratory, Department of Kinesiology and Health Education, University of Texas at Austin.The implications are, “non-fasting triglycerides ≥5 mmol/L vs. 14 hours a day and taking only 1650 steps per day, a 1-hour bout of running at 67% maximal oxygen consumption (VO2max) failed to improve postprandial hypertriglyceridemia the next morning.”It seems, notes the research, “that physical inactivity (i.e., high sitting and severely reduced step count) rendered the participants resistant to the normal acute improvements in indices of cardiometabolic health that are normally derived from a 1-hour bout of running” - a phenomenon labeled “exercise resistance” -becoming, “resistant to the normal acute improvements in indices of cardiometabolic health that are normally derived from a 1-h bout of running.”The takeaway message is that despite one hour of running at what would be considered a moderate pace – something many people would not tolerate – the prolonged running bout failed to kick start the metabolism, when sitting too long and taking few, total daily steps. It could be concluded that the extended running bout may have fatigued the runner, such that they sat longer and took fewer steps the rest of the day. That begs the question of what is the minimum step count to assist dietary restrictions to lower the post-meal elevated blood fat levels – understanding that a high saturated fat meal may keep the triglycerides elevated for up to 10 hours? Many heart attacks come in the early morning hours (2 to 3AM), following an evening high fat meal.For more information and to read the rest, go to maxwellnutrition.com.

Robert J. Silver, DVM, MS, chief medical officer of Rx Vitamins, has made it his mission to educate veterinary professionals about the importance of integrating nutraceuticals in traditional veterinary medical protocols. Dr. Silver is an active member of the Cannabis Clinicians Society, vice president of the American College of Veterinary Botanical Medical Association, and former president of the Veterinary Botanical Medical Association. He is a 1982 graduate of Colorado State University College of Veterinary Medicine. Register for his free live webinar airing tomorrow, 10/14 at 8pm EST here. 

Podcast Contents 00:00-8:56- Introduction by David A. Bluemke, MD, PhD, Editor of Radiology.   08:57- 15:51– Cross-sectional and Longitudinal Assessment of Brain Iron Level in Alzheimer Disease Using 3-T MRI. Damulina et al. Radiology 2020; 296:619–626. [Full Text]   15:52- 22:50– Evaluating Biochemically Recurrent Prostate Cancer:Histologic Validation of 18F-DCFPyL PET/CT with Comparison to Multiparametric MRI. Lindenberg et al. Radiology 2020; 296:564–572 . [Full Text]    22:51- 29:14 - Thoracic Bone Mineral Density Derived from Cardiac CT Is Associated with Greater Fracture Rate. Therkildsen et al. Radiology 2020; 296:499–508. [Full Text]    29:15- 32:03– Dual-Energy CT for Suspected Radiographically Negative Wrist Fractures: A Prospective Diagnostic Test Accuracy Study. Müller et al. Radiology 2020; 296:596–602. [Full Text]   32:03-35:03–Clinical Relevance of Multiparametric MRI Assessment of Cervical Cord Damage in Multiple Sclerosis. Bonacchi et al. Radiology 2020; 296:605–615. [Full Text]     35:04-35:35Conclusion by David A. Bluemke, MD, PhD, Editor of Radiology

Today I am talking all things breathing with Dr Rosalba Courtney. Rosalba is a true expert in the field of breathing . she has a PhD in breathing and is also an Osteopath with 35 years of experience. Rosalba's PhD was on 'Dysfunctional Breathing: Its Parameters, Measurement and Clinical Relevance" and she has published over 15 peer review articles and book chapters on this topic. She works in Edgecliff and in Avalon Sydney helping patients and athletes improve their breathing. She also conducts training programs for Oesteopaths , Physiotherapists, Dentists, Speech Therapists and other health professionals on Integrative Approaches to Assessing and Treating Dysfunctional Breathing. 

When I started panicking about the COVID-19, I thought getting tested would help me feel so much better. If I could see that beautiful “negative”, my mind would stop being so restless. After learning more about the COVID-19 testing methods, I find myself firmly believing that testing negative for COVID 19 is not that liberating at all. Hold on. Don’t panic! Let’s start reading, I will tell you why... - Research Paper - ( #Reading_COVID19 ) “Covid-19 diagnostic based on MIT technology might be tested on patient samples soon” by Anne Trafton , Jennifer CHu , David L. Chandler [ http://news.mit.edu/2020/covid-19-diagnostic-test-prevention-0312 ] “Mythbusters : the truth about coronavirus (COVID19)” by Gulf Coast regional Blood Center [ http://www.giveblood.org/mythbusters-the-truth-about-coronavirus-(covid-19)/ ] “Viral infection of the lungs through the eye” by Vira Bitko et al. ( Abstract only) [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797451/ ] “Coronavirus Disease 2019 (COVID-19) Pneumonia: Early Stage Chest CT Imaging Features and Clinical Relevance” by Chenying Lu et al. [ https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3543606 ] - Acknowledgments - Music: https://www.purple-planet.com - Twitter accounts, You might want to follow - Podcast : @ReadingSPaper Host : @NVidaYotcho P.s. please stay home !

When I started panicking about the COVID-19, I thought getting tested would help me feel so much better. If I could see that beautiful “negative”, my mind would stop being so restless. After learning more about the COVID-19 testing methods, I find myself firmly believing that testing negative for COVID 19 is not that liberating at all. Hold on. Don’t panic! Let’s start reading, I will tell you why... - Research Paper - ( #Reading_COVID19 ) “Covid-19 diagnostic based on MIT technology might be tested on patient samples soon” by Anne Trafton , Jennifer CHu , David L. Chandler [ http://news.mit.edu/2020/covid-19-diagnostic-test-prevention-0312 ] “Mythbusters : the truth about coronavirus (COVID19)” by Gulf Coast regional Blood Center [ http://www.giveblood.org/mythbusters-the-truth-about-coronavirus-(covid-19)/ ] “Viral infection of the lungs through the eye” by Vira Bitko et al. ( Abstract only) [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797451/ ] “Coronavirus Disease 2019 (COVID-19) Pneumonia: Early Stage Chest CT Imaging Features and Clinical Relevance” by Chenying Lu et al. [ https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3543606 ] - Acknowledgments - Music: https://www.purple-planet.com - Twitter accounts, You might want to follow - Podcast : @ReadingSPaper Host : @NVidaYotcho P.s. please stay home !

The facial vein is more consistent with its anatomy/relationship with the marginal mandibular nerve than the facial artery... Touré G, Tran de Fremicourt MK, Randriamanantena T, Vlavonou S, Priano V, Vacher C. Vascular and Nerve Relations of the Marginal Mandibular Nerve of the Face: Anatomy and Clinical Relevance. Plast Reconstr Surg. 2019

Join Dr. Kolb and colleagues covering the etiology, pathophysiology, monitoring, and emerging treatments for non-IPF progressive fibrosing ILDs Learning Objectives & Disclosures --- Full URLs: Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/914675?src=mkm_podcast_addon_914675

Topics: What is the Clinical Relevance of a “Teachable Moment?” Faculty: Joslyn Kirby, MD From the SDPA Annual Summer Dermatology Conference 2017. Learning Objectives: 1. Define “teachable moment” 2. How you can use your time to make a positive impact on your practice and patients 3. Provide examples of teachable [...]

This week we talk about taking the pressure out of the performance. Our guest this week is Raphael Bender from Breathe Education in Australia. He and Jenna talk about pain science, evolutionary teaching, and maybe even touch on a little controversy. Special thanks to: Pilates Anytime, Pilates Education Institute, Articulate Bodies, Pure Body, Profitable Pilates   Event Links: Pay it Forward For Mari Winsor Momentum Fest PMA Annual Meeting 2018   INFO FROM RAPHAEL BENDER: Research An Updated Overview of Clinical Guidelines for the Management of Non-specific Low Back Pain in Primary Care (2010) Psychological Factors are Associated with the Outcome of Physiotherapy for People with Shoulder Pain In Primary Care (2010) Does Fascia Matter? A Detailed Critical Analysis of the Clinical Relevance of Fascia Science and Fascia Properties Interesting Short Videos Understanding Pain in 5 Minutes | A simple, clear explanation put together by NSW Health Dept. Lorimer Moseley TEDx: Why Things Hurt | Lorimer Moseley is a cognitive neuroscientist and one of the world's most respected pain researchers. And a funny bloke. Peter O'Sullivan; Back Pain - Separating Fact From Fiction | Peter O'Sullivan is a PhD physiotherapist and back pain researcher at Curtin University in WA. Dr. Greg Lehman - Perfect Posture Doesn't Exist | Dr. Greg Lehman is a Physiotherapist, Chiropractor, and Biomechanist. Videos by Raphael Is Flexion Dangerous? A Look at the Evidence | Part 1, Part 2, Part 3, Part 4 Donut and the Hole What Causes Pain? Audio by Raphael Core Stabilization - No Better Than General Exercise When Do Biomechanics Matter? Diastasis Recti Abdominis - Why You Should Be Doing Ab Curls Posture - It Doesn't Really Matter For Pain      

In order for our neurons to fire off, heart muscle to contract, and kidneys to reabsorb substances, the cells in our body need to establish charge and concentration differences between the inside of the cell and outside the cell (resting membrane potential). In this episode, we explore how our body creates these differences and exploit them to send signals to and from the brain (action potential). We also discuss what can happen to the body if we alter these concentrations and charges.

In this episode, our panel look at so-called internet gaming disorder, prompted by a recent academic study. They discuss internet gaming, the potential risks, but also the benefits that gaming can bring, both to life in general (children doing maths homework, for example) and to protecting and sustaining good mental health. This is the second episode in our series of podcasts with the British Journal of Psychiatry. It discusses a recent research paper entitled "Internet Gaming Disorder: Investigating the Clinical Relevance of a New Phenomenon", which was published in the American Journal of Psychology and highlighted in the Kaleidoscope section of the British Journal of Psychiatry. The panel for this discussion featured: - Josefien Breedvelt, Research Manager at the Mental Health Foundation - Derek Tracy, Consultant Psychiatrist at Oxleas NHS Foundation Trust - Emma Wilson, mental health policy expert, well-known to some as @MindfulEm on Twitter.

Commentary by Dr. Valentin Fuster

David Vago, PhD and Lisa Dale Miller, LMFT, LPCC, SEP tackle the traditional Buddhist concept of "enlightenment" from their modern clinical points of view in a stimulating and fun discussion. Part 2 focuses on S-ART, David's neurobiological framework for describing the positive effects of meditation on self-awareness, self-regulation, and self-transcendence; Theravada, Mahāyāna and Vajrayāna notions of awakening and not-self; secular mental training; different interventions for different psyches; selflessness/emptiness in psychotherapy; translating the dharma into neuropsychological terms, vedanā (craving and aversion); decentering, embodied cognition; aggregates and seeds of habit mind; other-centeredness and not-self; non-referential compassion; empathy fatigue; refuting self-compassion; clinical Tonglen practice; neurobiological evidence for not-self states; developmental model of awakening; dynamic responsiveness; neurotherapeutics. David Vago, PhD is an associate psychologist in the Functional Neuroimaging Laboratory (FNL), Brigham and Women’s Hospital (BWH) and instructor at Harvard Medical School. David has previously held the position of Senior Research Coordinator for the Mind & Life Institute and is currently a Mind and Life Fellow. David’s research interests broadly focus on utilizing translational models to identify and characterize neurobiological substrates mediating psychopathology, to better predict outcomes and potential biologically-based diagnostic and therapeutic strategies for those suffering with mental illness. David has been specifically investigating brain networks supporting self-awareness, self-regulation, and self-transcendence in order to clarify adaptive mind-brain-body interactions and their therapeutic relevance in psychiatric disorders. http://davidvago.bwh.harvard.edu/ Lisa Dale Miller, LMFT, LPCC, SEP, is the author of "Effortless Mindfulness: Genuine mental health through awakened presence", a new textbook on Buddhist psychology. She is the creator of Awakened Presence Psychotherapy™ and is a private practice psychotherapist in Los Gatos, Ca. She specializes in mindfulness psychotherapy, Buddhist psychology and is a certified Somatic Experiencing Practitioner. Lisa trains clinicians in the application of mindfulness interventions and practical Buddhist psychology. Lisa has been a dedicated yogic and Buddhist meditation practitioner for four decades. http://www.lisadalemiller.com

David Vago, PhD and Lisa Dale Miller, LMFT, LPCC, SEP tackle the traditional Buddhist concept of "enlightenment" from their modern clinical points of view in a stimulating and fun discussion. This is the first part of their two-part conversation. Covered topics include: Contextualizing the terms enlightenment, awakening, liberation; demarcating clinical markers of progress on the path; Nirvana and mini-nirvanas; state vs trait changes of awakening; extinction of mental and emotional habits; dissolving greed, hatred and delusion; pure awareness or nature of mind; the inherent problems of quick fix mindfulness. David Vago, PhD is an associate psychologist in the Functional Neuroimaging Laboratory (FNL), Brigham and Women’s Hospital (BWH) and instructor at Harvard Medical School. David has previously held the position of Senior Research Coordinator for the Mind & Life Institute and is currently a Mind and Life Fellow. David’s research interests broadly focus on utilizing translational models to identify and characterize neurobiological substrates mediating psychopathology, to better predict outcomes and potential biologically-based diagnostic and therapeutic strategies for those suffering with mental illness. David has been specifically investigating brain networks supporting self-awareness, self-regulation, and self-transcendence in order to clarify adaptive mind-brain-body interactions and their therapeutic relevance in psychiatric disorders. http://davidvago.bwh.harvard.edu/ Lisa Dale Miller, LMFT, LPCC, SEP, is the author of "Effortless Mindfulness: Genuine mental health through awakened presence", a new textbook on Buddhist psychology. She is the creator of Awakened Presence Psychotherapy™ and is a private practice psychotherapist in Los Gatos, Ca. She specializes in mindfulness psychotherapy, Buddhist psychology and is a certified Somatic Experiencing Practitioner. Lisa trains clinicians in the application of mindfulness interventions and practical Buddhist psychology. Lisa has been a dedicated yogic and Buddhist meditation practitioner for four decades. http://www.lisadalemiller.com

David Vago, PhD and Lisa Dale Miller, LMFT, LPCC, SEP tackle the traditional Buddhist concept of "enlightenment" from their modern clinical points of view in a stimulating and fun discussion. Part 2 focuses on S-ART, David's neurobiological framework for describing the positive effects of meditation on self-awareness, self-regulation, and self-transcendence; Theravada, Mahāyāna and Vajrayāna notions of awakening and not-self; secular mental training; different interventions for different psyches; selflessness/emptiness in psychotherapy; translating the dharma into neuropsychological terms, vedanā (craving and aversion); decentering, embodied cognition; aggregates and seeds of habit mind; other-centeredness and not-self; non-referential compassion; empathy fatigue; refuting self-compassion; clinical Tonglen practice; neurobiological evidence for not-self states; developmental model of awakening; dynamic responsiveness; neurotherapeutics. David Vago, PhD is an associate psychologist in the Functional Neuroimaging Laboratory (FNL), Brigham and Women’s Hospital (BWH) and instructor at Harvard Medical School. David has previously held the position of Senior Research Coordinator for the Mind & Life Institute and is currently a Mind and Life Fellow. David’s research interests broadly focus on utilizing translational models to identify and characterize neurobiological substrates mediating psychopathology, to better predict outcomes and potential biologically-based diagnostic and therapeutic strategies for those suffering with mental illness. David has been specifically investigating brain networks supporting self-awareness, self-regulation, and self-transcendence in order to clarify adaptive mind-brain-body interactions and their therapeutic relevance in psychiatric disorders. http://davidvago.bwh.harvard.edu/ Lisa Dale Miller, LMFT, LPCC, SEP, is the author of "Effortless Mindfulness: Genuine mental health through awakened presence", a new textbook on Buddhist psychology. She is the creator of Awakened Presence Psychotherapy™ and is a private practice psychotherapist in Los Gatos, Ca. She specializes in mindfulness psychotherapy, Buddhist psychology and is a certified Somatic Experiencing Practitioner. Lisa trains clinicians in the application of mindfulness interventions and practical Buddhist psychology. Lisa has been a dedicated yogic and Buddhist meditation practitioner for four decades. http://www.lisadalemiller.com mindfulness,cognitive neuroscience,neuroscience of meditation,Buddhist teachings,effortless mindfulness,anxiety treatment,depression treatment,not-self,compassion training,empathy,S-ART

Hypomagnesemia and hypocalcemia are common adverse events during cetuximab treatment. The influence of the chemotherapeutic combination on serum levels is unknown and the predictive value is currently under discussion. This analysis investigated 79 patients who had received cetuximab for at least 6 weeks in the day clinic of the Comprehensive Cancer Center, University of Munich. Calcium and magnesium serum levels were analyzed weekly; tumor response and adverse events were followed. Thirty-eight patients had metastatic colorectal cancer (mCRC) and the predictive value of hypomagnesemia was tested in these patients. During therapy, calcium serum levels decreased to about 97% of the baseline levels and were maintained for the duration of treatment. Magnesium levels showed a significant time-dependent decrease. Serum levels of magnesium were lower when cetuximab was combined with a platinum derivative. After a treatment duration of 12 weeks, magnesium levels decreased to 70% in platinum-treated patients, whereas they decreased to only 90% of baseline in patients who did not receive platinum therapy. In patients treated for mCRC, a decrease of serum magnesium below 95% of the baseline levels 14 days after initiating treatment separated patients significantly in terms of survival times. Magnesium levels decrease in a time-dependent manner during cetuximab therapy. As hypomagnesemia was more prominent in patients receiving platinum agents, magnesium measurements may be advised in these patients. In mCRC patients treated with cetuximab, day-14 magnesium serum levels correlated with treatment efficacy.

Background: Graft hypertrophy is the most common complication of periosteal autologous chondrocyte implantation (p-ACI). Purpose: The aim of this prospective study was to analyze the development, the incidence rate, and the persistence of graft hypertrophy after matrix-based autologous chondrocyte implantation (mb-ACI) in the knee joint within a 2-year postoperative course. Study Design: Case series; Level of evidence, 4. Methods: Between 2004 and 2007, a total of 41 patients with 44 isolated cartilage defects of the knee were treated with the mb-ACI technique. The mean age of the patients was 35.8 years (standard deviation [SD], 11.3 years), and the mean body mass index was 25.9 (SD, 4.2; range, 19-35.3). The cartilage defects were arthroscopically classified as Outerbridge grades III and IV. The mean area of the cartilage defect measured 6.14 cm2 (SD, 2.3 cm2). Postoperative clinical and magnetic resonance imaging (MRI) examinations were conducted at 3, 6, 12, and 24 months to analyze the incidence and course of the graft. Results: Graft hypertrophy developed in 25% of the patients treated with mb-ACI within a postoperative course of 1 year; 16% of the patients developed hypertrophy grade 2, and 9% developed hypertrophy grade 1. Graft hypertrophy occurred primarily in the first 12 months and regressed in most cases within 2 years. The International Knee Documentation Committee (IKDC) and visual analog scale (VAS) scores improved during the postoperative follow-up time of 2 years. There was no difference between the clinical results regarding the IKDC and VAS pain scores and the presence of graft hypertrophy. Conclusion: The mb-ACI technique does not lead to graft hypertrophy requiring treatment as opposed to classic p-ACI. The frequency of occurrence of graft hypertrophy after p-ACI and mb-ACI is comparable. Graft hypertrophy can be considered as a temporary excessive growth of regenerative cartilage tissue rather than a true graft hypertrophy. It is therefore usually not a persistent or systematic complication in the treatment of circumscribed cartilage defects with mb-ACI.

Background: Clinical outcome of patients with head and neck squamous cell carcinoma (SCCHN) depends on several risk factors like the presence of locoregional lymph node or distant metastases, stage, localisation and histologic differentiation of the tumour. Circulating tumour cells in the bone marrow indicate a poor prognosis for patients with various kinds of malignoma. The present study examines the clinical relevance of occult tumour cells in patients suffering from SCCHN. Patients and Methods: Bone marrow aspirates of 176 patients suffering from SCCHN were obtained prior to surgery and stained for the presence of disseminated tumour cells. Antibodies for cytokeratin 19 were used for immunohistochemical detection with APAAP on cytospin slides. Within a clinical follow-up protocol over a period of 60 months, the prognostic relevance of several clinicopathological parameters and occult tumour cells was evaluated. Results: Single CK19-expressing tumour cells could be detected in the bone marrow of 30.7% of the patients. There is a significant correlation between occult tumour cells in the bone marrow and relapse. Uni- and multivariate analysis of all clinical data showed the metastases in the locoregional lymph system and detection of disseminated tumour cells in the bone marrow to be statistically highly significant for clinical prognosis. Conclusion: The detection of minimal residual disease underlines the understanding of SCCHN as a systemic disease. Further examination of such cells will lead to a better understanding of the tumour biology, as well as to improvement of diagnostic and therapeutic strategies.

Bipolar rapid cycling (RC) is defined as 4 or more affective episodes within 1 year. It has been postulated that RC is related to a poor response to lithium, to the same extent as mixed episodes or other atypical symptoms of the illness. This article reviews the current status of alternative pharmacological or otherwise supportive therapies of RC. Biological parameters and characteristics of the illness associated with RC like gender prevalence in women, hyperthyroid ism, catecholamine-O-methyltransferase allele, the influence of sleep, different subtypes of bipolar disorder and the risk of antidepressant-induced cycling will be discussed in detail. Copyright (C) 2002 S. Karger AG, Basel.

Concentrations of soluble c-erbB-2 were determined in the sera of 64 patients with distant metastasis from advanced breast cancer receiving second-line hormone or chemotherapy in comparison to 35 breast cancer patients without detectable recurrent disease and 17 healthy blood donors. The sera of non-metastatic breast cancer patients contained s-erbB-2 concentrations similar to those of healthy blood donors. Patients with distant metastasis from advanced breast cancer had significantly higher values of s-erbB-2 in comparison to patients with non-disseminated disease (mean: 59.6 vs. 11.6 U/ml; p = 0.022). A significant correlation was observed between s-erbB-2 serum levels and serum LDH concentrations (p < 0.001), levels of alkaline phosphatase (p < 0.001), and the presence of hepatic metastasis (p = 0.001). Time to tumor progression was significantly shorter in patients with s-erbB-2 levels above 40 U/ml (mean: 23.4 vs. 56.7 months; p = 0.002). Furthermore, breast cancer patients with hepatic metastasis and those with elevated s-erbB-2 serum levels above 40 U/ml had limited response to hormone or chemotherapy. Non-responders had significantly higher s-erbB-2 levels (mean: 270.3, range: 42-500 U/ml;) compared with the responder group (mean: 23.1, range: 0-149 U/ml; p < 0.001). Logistic regression analysis indicated that elevated s-erbB-2 serum levels above 40 U/ml independently predicted an unfavorable response to second-line hormone or chemotherapy in patients with advanced metastatic breast cancer. Copyright (C) 2002 S. KargerAG, Basel.

Wed, 1 Jan 1992 12:00:00 +0100 https://epub.ub.uni-muenchen.de/9834/1/9834.pdf Fritz, Hans; Redl, H.; Waydhas, Christian; Machleidt, W.; Joka, T.; Inthorn, D.; Jochum, Marianne