Podcast appearances and mentions of James Lee

The Kaspa network just got its long-awaited DeFi moment!

Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Fei Li Kuang, MD, PhD, an allergist and immunologist, at Northwestern Medicine, about receiving two APFED HOPE on the Horizon Grants. Disclaimer: The information provided in this podcast is designed to support, not replace, the relationship between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own.   Key Takeaways: [:50] Co-host Ryan Piansky introduces this episode, brought to you thanks to the support of Education Partners GSK, Sanofi, Regeneron, and Takeda. Ryan introduces co-host Holly Knotowicz.   [1:14] Holly introduces today's topic, two APFED HOPE on the Horizon Pilot Grant Projects and today's guest, Fei Li Kuang, MD, PhD, an Assistant Professor in the Division of Allergy and Immunology at Northwestern University Feinberg School of Medicine in Chicago, Illinois.   [1:42] Dr. Kuang is a physician-scientist who takes care of patients with eosinophilic disorders and also performs laboratory research on these disorders in her lab, often using patient samples. Holly thanks Dr. Kuang for joining us.   [2:05] As a child, Dr. Kuang always wanted to be a scientist. She is so grateful to live out her childhood dream, and it's because of the amazing people who have supported her, most importantly, her parents.   [2:29] In graduate school, Dr. Kuang studied B cells. When she went on to do an allergy fellowship, she thought she would study B cells and care for patients with B cell problems. Instead, she fell in love with allergy and eosinophilic disorders.   [2:50] Dr. Kuang is here, in part, because of the different mentors she has had, and in large part, because of the patients she has met along the way.   [3:20] Dr. Kuang had the opportunity to work with Amy Klion at the NIH in a clinical trial to treat patients with a drug that gets rid of eosinophils. She says it was a dream come true after her training.   [4:02] She says she learned so much about eosinophils, their unusual biology, and the mystery behind what they are here for. She got hooked.   [4:15] Dr. Kuang thinks the patients you meet in a clinical trial in a special place like NIH occupy a space in your heart that makes you want to keep working on the subject area.   [4:34] Patients in a clinical trial have given up a bunch of their time to travel to Bethesda, Maryland. For the trial Dr. Kuang participated in as a Fellow, it was a good year of their time to come out and do it.   [4:47] Dr. Kuang felt there were so many interesting questions, from an intellectual point of view, but there was also a real need from patients with chronic conditions. It was a beautiful opportunity to marry scientists with physicians in training.   [5:36] Dr. Kuang shares some knowledge about eosinophils. They are white blood cells that are in all of us. They have little pink packages or granules that "jumped out" in the light microscope almost 200 years ago, when we first identified them.   [6:00] Dr. Kuang says that animals, dating back to reptiles, and different species of dolphins, all have eosinophils. A veterinary scientist, Dr. Nicole Stacy of the University of Florida, has taken photos of eosinophils from all these different species.   [6:21] They've been around for a long time. What are they good for? What we know is that they are associated with disease conditions, such as asthma and others, including leukemia. Those were the classic first studies of eosinophils.   [6:42] Now, we have a different mindset about eosinophils from work by the late James Lee at Mayo Clinic, Arizona.   [6:58] Dr. Kuang credits Dr. Lee with suggesting that eosinophils not just cause us problems but also help treat parasitic infections, maintain tissue homeostasis, help wound healing, and tissue repair. That's a new area we are beginning to appreciate.   [7:41] Dr. Kuang says we need to be open-minded that in some circumstances, eosinophils may be helpful or innocent. Now we have tools to start to understand some of that. We need to collect information from patients being treated with medicines.   [8:10] Ryan tells of being diagnosed as a kid. Doctors explained to him that eosinophils fight parasites, but in some people, they get confused and attack the esophagus. That's EoE. That was easy to understand, but he knew that the researchers knew more.   [8:53] Ryan is grateful to the patient population around eosinophilic esophagitis, and is proud of APFED's support of patients and caregivers with HOPE Grants. APFED has the HOPE on the Horizon Research Program, entirely funded by community donations.   [9:13] To date, APFED has directed more than $2 million toward eosinophilic disease research initiatives through various grant programs. As a patient advocacy organization, APFED works with fantastic researchers who submit innovative research ideas.   [9:32] These research ideas go through an extensive and competitive peer-review process, supported by researchers and clinicians in the APFED community.   [9:42] Today, we're going to discuss two different projects supported by HOPE Pilot Grants with Dr. Kuang.   [10:00] Dr. Kuang thinks there are two ways these grant programs are important to patients. One is advancing research by nurturing seedling investigators. Dr. Kuang got her first grant when she was a Fellow. It was an incredible opportunity.   [10:25] These grant programs also nurture seedling ideas that don't have enough evidence yet to garner the larger NIH grants, and so forth. There are other sources for grants: pharmaceutical companies. The grant programs are for seeds.   [10:49] Patients need to know that there are new things that are given some chance of being tested out. Research takes some time, and the FDA process of getting a drug approved is long.   [11:04] For the newly diagnosed patient, it can feel overwhelming. It feels like there's a loss of control. Sometimes, participating in something like APFED, being part of a community, gives back a sense of control that is lost when you're handed a diagnosis.   [11:45] For patients who have had it for a long time, when they participate in research and become engaged in organizations like APFED, they know they may not directly benefit today, they may benefit later, but they hope future patients will benefit.   [12:21] That gives them a sense of control and hope that things will be better for the next generation. We all want that, especially in medicine, in something that we don't have a very deep understanding of.   [12:58] Dr. Kuang received two HOPE Pilot Grants, one in 2018 and one in 2022. The first grant was awarded when she was a Fellow at the NIH.   [13:05] That first grant explored some effects of eosinophilic depletion of pathogenic lymphocytes in hypereosinophilic syndrome and overlaps with EGIDs. Ryan asks for a broad overview of that research.   [13:25] When Dr. Kuang was a Fellow at the NIH, they were doing a Phase 2 clinical trial, looking at "blowing up" eosinophils in patients who have a lot of them, hypereosinophilic syndrome patients.   [13:39] They included patients who had eosinophilic GI disease, often beyond the esophagus. They may have esophageal involvement, but sometimes their stomach is impacted, sometimes their large bowel is impacted, with related symptoms.   [13:57] What Dr. Kuang and the team noticed in the trial was that just within that little group of patients, there were people who did well, and people who did much better than before, but would have recurrent symptoms, and with no eosinophils in their GI tissues.    [14:16] The researchers wanted to know what was causing these problems for the patient. If you take eosinophils away, what other factors will impact the immune system of the patient, semi-long-term?   [14:32] Their focus was on these groups of patients who had different responses. They looked at the white blood cells that had been previously described as being the responsible, "bad" T cells that lead to eosinophils in the gut.   [14:49] They found that the patients who had recurrent flares of the disease had more of the bad T cells, and the patients who responded well and never complained again about symptoms did not.   [15:03] That allowed researchers to identify that there were subsets of patients with the disease that they were calling the same thing.   [15:18] Dr. Kuang says that work also led them to find that those cells were being reported in patients who had food allergies for which they needed an epinephrine auto-injector.   [15:27] The researchers were curious whether that was just a food allergy issue, or only applied if you had food allergies and eosinophilic GI disease. That HOPE project allowed them to do a pilot study to look at food allergy patients, too. They did, and published it.   [15:45] They published that in patients who have a food allergy and have these T cells, the insides of those cells make different messages for the immune system than the ones that the researchers had previously described.   [16:01] In looking for why there were differences in those responses, they accidentally found that there were differences inside these cells in a completely different disease, which also had these T cells.   [16:21] Dr. Kuang says that the finding was kind of a surprise. If they had found anything in the eosinophilic GI disease patients, that would have been good. They also looked at the epithelial cells and the structure of the GI lining.   [16:42] Even though there were no eosinophils in the GI lining in the patients who had been treated with a biologic that depleted eosinophils, their GI lining still looked like the GI lining of patients who had eosinophilic GI disease.   [16:55] Dr. Kuang asked what was creating those spots. Our gut lining sheds, so there should have been an opportunity for the GI lining to turn over and look new. Something was there, making signals to create these spots. They did a different publication on that.   [17:21] The data from the HOPE Pilot study allowed Dr. Kuang to apply for larger grants. It allowed her to propose to the company that made this drug, when they did the Phase 3 trial, to insert into that special study the study on eosinophilic GI disease.   [17:48] Do patients with eosinophilic GI disease do better or worse on this drug, and how do the T cells look in that trial? That HOPE Grant gave Dr. Kuang the data to ask the drug company to give her money to study it in an international cohort of patients.   [18:17] There were only 20 patients in that first NIH trial, who gave a year of their life, coming to NIH all the time. They continued to be in the study until the drug was approved for asthma.   [18:28] Dr. Kuang says the main reason the company did the Phase 3 trial, which is expensive, and the market share is not huge because it's a rare disease, is that two of the patients went to bat for this disease population.   [18:47] The two patients went and showed the business people what they looked like before, what the drug had done for them, and how their lives had changed. It wasn't the doctors or the great paper from the trial, but the patients who convinced the company.   [19:01] Dr. Kuang says she was so floored by that and moved by what they did for the community. She is grateful.   [19:24] Since the Phase 3 trial, Dr. Kuang and the other researchers realized they had not fully studied the eosinophils. They had studied them in part. They found differences in response. This inspired the second APFED HOPE Pilot Grant.   [21:19] In 2022, Dr. Kuang received a two-year APFED HOPE Pilot Grant to examine how blood eosinophils in Eosinophilic Gastrointestinal Diseases differ from those of other eosinophilic diseases and how T cells in EGIDs differ from those in food allergies.   [21:49] Dr. Kuang says normally, the biggest place of residence for eosinophils is the GI tract. That's where they are normally seen in people who do not have eosinophilic disorders.   [21:59] People who have eosinophilic disorders that attack other parts of the body, asthma, and rarely, the heart. Dr. Kuang was curious to know why one person and not the other?   [22:15] Patients who have eosinophilic GI disease often ask, How do you know this high level in the blood is not going to attack my heart or my lungs in the future? Dr. Kuang does not know.   [22:29] Dr. Kuang says, looking at the cohort at the NIH, that for many patients who have both GI organ involvement and some other space, when they first went to see a provider, their first complaint was a GI condition.   [22:54] If the doctor had only diagnosed a GI condition, nothing else, that would have been wrong. Those patients may not have been monitored as well. A third of the patients originally presented like that.   [23:11] What that meant was that we should be paying attention to patients who have GI disease who have lots of eosinophils in their blood. Moving forward, if there are new complaints, we need to investigate. We can't forget they have that.   [23:27] Dr. Kuang asks, Wouldn't it be great if we had a better tool than needing to wait? Wouldn't it be great if we had a biomarker that said the eosinophils have switched their target location and are going somewhere else?   [23:41] One way to do that is to take different groups of eosinophils and look for differences between those that never target the GI tract and those that do. In patients who have EoE, the eosinophils only target or cause problems in the esophagus.   [23:58] Are their eosinophils any different than those of a healthy person, with none of these conditions? That was the goal of that study.   [24:10] T cells are another type of white blood cell. They contain a memory of foreign things they have encountered, which allows them to glom onto flu, COVID, peanuts, pollen, that kind of thing. They remember.   [24:32] Dr. Kuang says they learned that T cells, at least in the mouse model, are required in the development of eosinophilic esophagitis. The mice in the old study, where mice were forced to develop EoE, did not get EoE if you removed their T cells.   [24:50] In the first APFED HOPE grant study, Dr. Kuang found T cells in the blood and tissue of both EGIDs and food allergy patients, but the insides of the T cells were different. The food allergy patients were children recruited by a pediatric allergist.   [25:19] In the second APFED HOPE grant study, at Northwestern, Dr. Kuang recruited her adult food allergy patients. That was a way to validate what they found in the first study and move further to better characterize those T cells in the two different diseases.   [25:47] Dr. Kuang says we're at a point where we've recruited a lot of people. She says it's amazing what people are willing to do. It's very humbling.   [26:06] Dr. Kuang's team in the lab is really great, too. To accommodate patients, they would see them after work, if that's what they had to do to isolate eosinophils. So they did that, and now they are in the process of analyzing that data. It's really exciting.   [26:28] What's exciting is that they are seeing results that show that eosinophilic GI disease patients have circulating eosinophils that are different from the eosinophils of people who don't have GI involvement, and from people who have EoE.   [26:46] The EoE patients have eosinophils different from those of healthy donors. Dr. Kuang says there's a lot of promise for perhaps unique signatures that could help define these conditions; maybe someday without biopsying, but that's a long time away.   [27:16] Dr. Kuang says they will focus on some candidate targets and try to recreate some of that in a dish with eosinophils from healthy people.   [27:26] What are the signals that lead eosinophils to do this, and can we translate that back to available drugs that target certain cytokines or other pathways, and maybe give some insight to develop drugs that target other pathways for these diseases?   [28:17] Ryan thinks it's exciting that this research is narrowing in on not only the different symptoms, but also how the eosinophils are acting differently in these populations.    [28:44] Dr. Kuang is super excited about this research. You could imagine that all eosinophils are the same, but you don't know until you look. When they looked, using the newest technology, they found there were differences.   [29:33] Dr. Kuang says it is thought that T cells respond to triggers. We don't think eosinophils have a memory for antigens. T cells do. That's one of their definitions. When T cells react to a trigger, they give out messages through cytokines or by delivery.   [30:20] Those are the messages that recruit eosinophils and other cells to come and stir up some trouble.   [30:28] In the mouse model, where you don't have the T cells, and you don't get eosinophilic esophagitis in the particular way they made it happen in a mouse, that middle messenger is gone, so the eosinophils don't know where to go.   [30:44] With drugs that take out eosinophils, you think that you've gotten rid of the cell that creates all the problems. It shouldn't matter what the message says because there's no cell there to cause the damage.   [30:58] What Dr. Kuang learned is that, at least in certain eosinophilic GI diseases, that's not true. You erase the eosinophils from the picture, but that message is still coming.   [31:10] Who's carrying out the orders? Or is that message maintaining the wall of epithelial cells in a certain way that we didn't appreciate because the eosinophils were also there?   [31:24] It's important to study both, because one is the messenger and the other is one of the actors. Whether all of the actions taken by eosinophils are bad, or maybe some of them were meant to be good, we have yet to learn.   [31:40] At the moment, we're using it as a marker for disease activity, and that may change in the future, as we learn more about the roles of these cells in the process.   [31:50] We have drugs now that target eosinophils and drugs that target T cells. Dr. Kuang thinks it's important to study both and to study the impact of these drugs on these cells.   [32:02] You could theoretically use these drugs to understand whether, if someone responds to it, what happens to these cells, and if someone doesn't respond to it, what happens to these cells, and how this disease manifests in this flavor of patients.   [32:54] Dr. Kuang says, Often in science, we take a model. We think this works this way. Then, if this works this way, we expect that if we remove this, these things should happen. We did that with the first clinical trial, with NIH patients.   [33:10] It didn't quite happen the way we thought, so we had to go looking for explanations. These were unusual setbacks. Sometimes you have unusual findings, like the food allergy part.   [33:24] When Dr. Kuang went to Northwestern, she saw different cohorts of patients than she saw at NIH. She saw people who were seen every day, which is a different spectrum than those who are selected to be enrolled in a study protocol at the NIH.   [33:42] That broadened her viewpoint. It's maybe not all food-triggered. They were seeing adults who'd never had food allergies or asthma their whole life, and they had eosinophilic esophagitis suddenly as a 50-year-old. There's a significant group of them.   [34:10] What Dr. Kuang learned and tries to be open-minded about is that where you train, what sorts of patients you see, really shape your viewpoint and thinking about the disease process and the management process.   [34:24] Dr. Kuang says she was so lucky to have experienced that at a quaternary care referral center like the NIH and at an academic center like Northwestern, where there are fantastic gastroenterologists who see so many of these patients.   [34:56] Dr. Kuang and an Allergy Fellow knew they were going to get a wonderful data set from the NIH patients they had recruited, so they thought they had better look deeply at what had been learned before with older technology, with mice and people.   [35:13] They decided to gather previous research, and that ultimately got published as an article. From that research, they learned that people did things in many different ways because there was no standard. They didn't know what the standard should be.   [35:28] Different things you do to try to get eosinophils out of tissue impact how they look, in terms of transcript, gene expression, and what messages they make to define themselves as an eosinophil.   [35:43] They also learned that because eosinophils are hard to work with, they die easily, and you can't freeze them and work on them the next day; you can introduce issues in there that have to be accounted for.   [35:59] They learned that as an eosinophil research community, they ought to come up with some standards so that they can compare future studies with each other. Dr. Kuang says it was impossible to compare the old studies that used different premises.   [36:50] Dr. Kuang says we need to be proactive in creating the datasets in a standard way so that we can compare and have a more fruitful and diverse community of data. It's hard to use the old data.   [37:57] Dr. Kuang says they get fresh blood from patients, and because eosinophils are finicky, they need to be analyzed within four hours, or preserved in a way to save whatever fragile molecules are to be studied.   [38:19] If you let it sit, it starts dying, so you won't have as many of them, and they start changing because they're not in the body. Dr. Kuang experimented with putting a tube of blood on the bench and checking it with the same test every two hours. It changes.   [38:38] Four hours is a standard to prevent the eosinophils from dying. Patients need treatment. If a patient is hospitalized and needs treatment, Dr. Kuang's team needs to be there to get a sample before treatment is started.   [39:03] The treatment impacts it, changing the situation. Much of the treatment, initially, is steroids. When you give lots of steroids, the eosinophils go away. It's no good to draw their blood then.   [39:27] Dr. Kuang also gets a urine sample. The granules of the eosinophils can get into the urine. As they study people with active disease, they want to capture granule proteins in the urine as a less invasive way to monitor activity in different disease states.   [40:04] The patient just needs to give Dr. Kuang either arm and a urine sample.   [41:04] Dr. Kuang explains, you can count your eosinophils after four hours, but to study them, they have different flags of different colors and shapes. Those colors and shapes may mean that it's an activated eosinophil, or they may have other meanings.   [41:41] Dr. Kuang focused on markers that look at whether it's going to spill its granules and some traditional markers of activation.     [41:50] Everyone chooses a different marker of activation. So they decided to look at as many as they could. One marker is not sufficient. They seem to be different in different conditions. The markers are on the surface; you need to analyze them right away.   [42:20] Then, Dr. Kuang breaks open the eosinophils and grabs the messenger RNA. They preserve it to do sequencing to read out the orders to see what this eosinophil is telling itself to make. RNA chops up messages.   [43:00] When you open an eosinophil, a protein you find is RNA, which chops up messages, destroying parts of the cell. You want to save the message. There's a brief time to analyze the eosinophil. Dr. Kuang works to preserve and read the message.   [44:04] Dr. Kuang hopes someday to run a tube of blood, look at the flags on the eosinophils, and say, "I think your eosinophilic GI disease is active," or "You have a kind of eosinophilic GI disease we need to monitor more frequently for organ damage."   [44:38] If another patient doesn't have those flags, Dr. Kuang could say, "I think the chances that you're going to have involvement elsewhere are low." That can give reassurance to folks who are worried.   [45:15] Dr. Kuang hopes that someday we can understand better why some people have food allergies vs. eosinophilic GI disease. They both have T cells, but the T cells have different packages inside with messages to deliver.   [45:34] Every day, Dr. Kuang has to tell patients she doesn't have that answer. Someday, she hopes she can tell a patient she does have that answer.   [46:35] Dr. Kuang tells about an NIH grant she's excited about and the patients she recruits after therapy, or elimination diets, to examine eosinophils and T cells, to see the impacts their treatments or diets have had on eosinophilic GI disease.   [47:18] Dr. Kuang believes there will be predictors of who will respond to an elimination diet and who will respond to steroid therapy. She hopes one day to have that, rather than going through rounds of six to eight weeks followed by a scope.   [47:34] If you have an elimination diet for six to eight weeks, every time you add back a food, you have to do a scope. Dr. Kuang says it would be great if you could be more precise ahead of time for therapy.   [47:48] Dr. Kuang says these wonderful drugs selectively take out parts of the pathway in the immune system. They provide real-life opportunities to ask, why is this important in human biology and the human immune system?   [48:15] Dr. Kuang finds the knowledge itself fascinating and useful. She hopes it informs how we choose future drugs or therapeutic avenues to get the best we can out of what we've learned, so we have more targeted ways of treating specific diseases.   [48:48] Ryan is grateful for all the research happening for the eosinophilic disease community and all the patients participating in the research. He asks Dr. Kuang how a patient can participate in research.   [49:12] There are lots of ways to be involved in research. Dr. Kuang says her patients come away from participating in research feeling good about having done it.   [49:22] Answer a survey, if that's what you have bandwidth for. Where therapies are changing, being a part of a community is good for the community, for the future, but it's good for you, too. It's healing in ways that are not steroids or biologics.   [49:58] Being part of a community is healing in ways we all need when we feel alone and bewildered. You're not alone.   [50:12] There are many ways to participate: APFED, CEGIR, individual institutions, and clinical trials. They all have different amounts of involvement. It's worthwhile to participate, not only for future patients but for yourself. They're fantastic!   [50:56] Dr. Kuang talks about the privilege as a physician of working with APFED and other organizations to do this work.   [51:09] Holly thanks Dr. Kuang for sharing all of this research and exciting information.   [51:25] Dr. Kuang is excited about what her group is doing and is hopeful. Besides showing up for this disease, we have to show up for research, in general, in this country. It's a dark time for NIH research funding.   [51:55] Dr. Kuang asks the young listeners who are thinking of choosing a field to see the potential and get into it, study this, and believe that there's going to be a future with a more nurturing research environment.   [52:36] Dr. Kuang would hate to lose generations of scientists. She says that once she was a little girl who was trying to be a scientist. Her parents had no connections with scientists or doctors, but she was able to get into research, and she thinks you can, too.   [53:48] As a graduate student, Ryan has always been interested in trying to improve things, and he sees hope on the horizon. He's very grateful to the APFED community for supporting these research HOPE Pilot Grants.   [54:17] Ryan is very grateful to Dr. Kuang for joining us today.   [54:22] For our listeners who want to learn more about eosinophilic disorders, we encourage you to visit apfed.org and check out the links in the show notes.   [54:28] If you're looking to find a specialist who treats eosinophilic disorders, we encourage you to use APFED's Specialist Finder at apfed.org/specialist.   [54:37] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at apfed.org/connections.   [54:57] Dr. Kuang thanks Ryan and Holly and says she enjoyed the conversation. Holly also thanks APFED's Education Partners GSK, Sanofi, Regeneron, and Takeda for supporting this episode.   Mentioned in This Episode: Fei Li Kuang, MD, PhD, Allergist and Immunologist, Northwestern Medicine   Grants and publications discussed: Apfed.org/blog/apfed-announces-2018-hope-apfed-hope-pilot-grant-recipient/ Apfed.org/blog/fei-li-kuang-hope-pilot-grant-award/  Pubmed.ncbi.nlm.nih.gov/39213186/ Pubmed.ncbi.nlm.nih.gov/37487654/   APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections apfed.org/research/clinical-trials   Education Partners: This episode of APFED's podcast is brought to you thanks to the support of GSK, Sanofi, Regeneron, and Takeda.   Tweetables:   "I think the patients that you meet in a clinical trial, especially in a special place like NIH, occupy a space in your heart — I don't mean to be all too emotional about this — that makes you want to keep working on the subject area." — Fei Li Kuang, MD, PhD   "When I was a Fellow at the NIH, we were doing a Phase 2 clinical trial, looking at, for want of a better word, "blowing up" eosinophils in patients who have a lot of them, hypereosinophilic syndrome patients." — Fei Li Kuang, MD, PhD   "We're at a point where we've recruited a lot of people. I've had patients drive from the northern part of Illinois … come down and give me blood. It's amazing what people want to do and are willing to do. It's very humbling, actually." — Fei Li Kuang, MD, PhD   "You erase the eosinophils from the picture, but that message is still coming. Who's carrying out the orders? Or is that message maintaining the wall of epithelial cells in a certain way that we didn't appreciate because the eosinophils were also there?" — Fei Li Kuang, MD, PhD   "We need to be proactive in creating the datasets in a standard way so that we can compare and have a more fruitful and diverse community of data." — Fei Li Kuang, MD, PhD   "I think it's worthwhile to participate [in a clinical trial], not only for the future people but for yourself." — Fei Li Kuang, MD, PhD   Guest Bio: Fei Li Kuang, MD, PhD, is currently an Assistant Professor in the Division of Allergy and Immunology at Northwestern University Feinberg School of Medicine in Chicago, IL. She is a graduate of the Albert Einstein College of Medicine Medical Scientist Training Program with both a PhD in Cell Biology/Immunology and an MD.  She completed her Internal Medicine Residency at Columbia University, New York Presbyterian Hospital in New York City, she did her Fellowship in Allergy and Immunology at the National Institute of Allergy and Infectious Disease (NIAID) in Bethesda, Maryland. She is a physician-scientist who takes care of patients with eosinophilic disorders and also performs laboratory research on these disorders in her lab, often using patient samples.

Dr. James Lee Choron is a life-long natural sensitive whose abilities have shaped decades of research into the paranormal, the afterlife, and the subtle energies that influence human experience. Combining his intuitive gifts with a disciplined analytical approach, Dr. Choron has investigated hauntings, spiritual phenomena, and unexplained encounters across multiple continents. His work bridges the academic and the mystical, offering rare insight into the lived experience of a genuine sensitive who has spent his life documenting, interpreting, and translating the unseen world for the broader public. With his unique blend of scholarship, intuition, and first-hand experience, Dr. Choron stands as one of the more compelling voices in contemporary paranormal studies.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-x-zone-radio-tv-show--1078348/support.Please note that all XZBN radio and/or television shows are Copyright © REL-MAR McConnell Meda Company, Niagara, Ontario, Canada – www.rel-mar.com. For more Episodes of this show and all shows produced, broadcasted and syndicated from REL-MAR McConell Media Company and The 'X' Zone Broadcast Network and the 'X' Zone TV Channell, visit www.xzbn.net. For programming, distribution, and syndication inquiries, email programming@xzbn.net.We are proud to announce the we have launched TWATNews.com, launched in August 2025.TWATNews.com is an independent online news platform dedicated to uncovering the truth about Donald Trump and his ongoing influence in politics, business, and society. Unlike mainstream outlets that often sanitize, soften, or ignore stories that challenge Trump and his allies, TWATNews digs deeper to deliver hard-hitting articles, investigative features, and sharp commentary that mainstream media won't touch.These are stories and articles that you will not read anywhere else.Our mission is simple: to expose corruption, lies, and authoritarian tendencies while giving voice to the perspectives and evidence that are often marginalized or buried by corporate-controlled media

25 titres et 2 heures de musique ! Tracklist : What About Me – ChicI Told Ya – dexter in the newsagentInfrared Dot Com – Boldy James; Nicholas CravenJust – BicepRoot Of All Evil – Daniel CaesarFrankly, Mr. Shankly – The SmithsDe Madruga – RosalíaGrow Up!!! – bassvictimFaces – ClioDo You… (Cashmere Cat Remix) – MiguelGo Girl – Summer WalkerRow Fisherman – The CongosPlay Me – FcukersNuthin' But A “G” Thang – Dr. DreGMFU – SydHigher Than The Sun – Primal ScreamWaterloo Sunset – The KinksStrange People Feat. Rhye – CrayonSage Comme Une Image – LioEchoes – SorryDisco Cubizm (Daft Punk Remix) – I:CubeThe Kids Don't Stand A Chance – Vampire WeekendYou Don't Exist – MechatokLong Live A$ap – A$ap RockyRight On The Tip Of My Tongue – Brenda & The TabulationsHébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Mary Cosby isn't the only one holding people to the fire — longtime RHOC producer James Lee sits down with Chef Stuart O'Keeffe on Don't Let It Stu to unpack what really happened with Gretchen Rossi's liked posts, why Katie vanished for half the season, and how cast power plays could shape RHOC season 20. They also talk potential returns for Vicki Gunvalson, Emily vs. Gina casting choices, Stu's budget-friendly Trader Joe's Thanksgiving drama, and why The Real Housewives of Salt Lake City plane fiasco with Meredith Marks is driving producers crazy behind the scenes. 00:00 Trader Joe's $70 Thanksgiving Reel, Hater Backlash & Stu's Holiday Cooking Plans 05:50 Stu's New Smart Fridge Saga: Turning Off the Building's Water to Get It Installed 08:18 RHOC Reunion Fallout: Gretchen Rossi's Liked Posts, “Cyber Hacker” Excuse & Accountability 12:53 What Really Happened to Katie? Producer James Lee on Cast Gang-Ups & Katie Vanishing for 6 Episodes 20:03 RHOC Season 20 Cast Predictions: Vicki, Tamra, Shannon, Gretchen, Emily vs Gina & Alexis Returning 27:01 Inside Housewives Production: How RHOC Storylines Actually Form & Why Fresh Blood Matters 29:21 RHOSLC Plane Fight Mystery: Meredith's Alleged Meltdown, TikTok Cheating Rumors & Missing Footage 36:20 RHOBH Newbies, Housewife Shake-Ups & Stu's Viral Thanksgiving Stuffing Recipe Story Chef Stu Social - send your questions for “Kitchen Quick Fix” Instagram: ► https://www.instagram.com/chefstuartokeeffe Facebook: ► https://www.facebook.com/chefstuartokeeffe Youtube: ► https://www.youtube.com/chefstuartokeeffe TikTok: ► https://www.tiktok.com/@chefstuart?lang=en Chef Stu's Cookbooks & Seasoning: Quick Six Fix - ► https://amzn.to/49zVeB0 Cook It, Spill It, Throw It: The Not-So-Real Housewives Parody Cookbook - ► https://amzn.to/49A8UMi Chef Stu's Spice Blends - ► https://spicetribe.com/collections/chef-stu Chef Stu's Lovely Seasonings - ►https://chefstuart.com/collections/seasonings GEAR WE USE TO MAKE PODCASTS: https://amzn.to/4dg7uZF SOFTWARE WE USE TO MAKE PODCASTS: https://hurrdatmedia.com/our-gear/ A Hurrdat Media Production. Hurrdat Media is a digital media and commercial video production company based in Omaha, NE. Find more podcasts on the Hurrdat Media Network and learn more about our other services today on HurrdatMedia.com. http://hurrdatmedia.com/ #rhoc #realhousewives #gretchenrossi #tamrajudge #katieRHOC Learn more about your ad choices. Visit megaphone.fm/adchoices

In 1 Thessalonians 3, the apostle Paul gives us three keys to a resilient faith. These three keys are to understand three callings that God has given to us - a calling to suffer, a calling to love, and a calling to grow. Each of these callings is important for believers to understand and live out. We draw our ultimate motivation to respond to these callings by fixing our eyes on Jesus and growing in our daily dependence upon him.

Thank you for watching All Peoples Church live stream. Dr James Lee shares a sermon on God's fire and revival. Service from November 9, 2025. For more information, please visit our website, www.allpeopleschurch.us or find us on social media!

09/11/25 | James Lee | Romans 11 by City Church Bristol

In this week's episode we're taking a closer look at infrastructure's use of data – how emerging digital technologies and AI tools are shaping and transforming the way we manage our built and natural environment.To help me I am joined by James Lee, the new Chief Operating Officer at global infrastructure giant Bentley Systems in a quiet corner of the annual Year in Infrastructure tech gathering and celebration in Amsterdam.  It is clearly a moment when global infrastructure delivery faces unprecedented pressures — from net zero targets and climate resilience; to skills shortages and digital transformation.And as we have been hearing at the event, Bentley stands at the intersection of engineering and innovation with a mission “to close the gap between what the world demands and what we are able to deliver – as chief executive Nicolas Cumins puts it.So a lot to chat through with James today. He joins Bentley after a two-decade career spanning Google Cloud and SAP and so, I think, brings a unique perspective on operational challenges, AI integration, and the power of partnerships to drive transformation at scale.Let's explore how James plans to align these innovations with the realities of infrastructure delivery.ResourcesBentley Systems Year in InfrastructureBentley Systems websiteInfrastructure Policy Advancement - TIPLive summitsGoogle Cloud

19/10/25 | James Lee | Come and See Part 3 by City Church Bristol

“Let's not try to hit the brain, let’s try to hit the heart. Let the story really relate to what we wanna say, not just literally, but emotionally.”

05/10/25 | James Lee | Come & See Part 1 | John 1:1-18 by City Church Bristol

This week we have a very different experience in academia with Dr. James Lee. He tells his story of growing christian, how he got out, and how he found his way as a philosophy professor in a real university (as opposed to pretend evangelical ones). It's an amazing conversation about getting out of church, teaching, and life as an AAPI professor today.Chapel Probation is part of the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Dauntless Media Collective⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Join the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Dauntless Media Discord ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠for more conversation with all the podcast communities.Scott's book, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Asian-American-Apostate- Losing Religion and Finding Myself at an Evangelical University⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ is available now!Music by Scott Okamoto, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Jenyi⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Azeem Khan⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Shin Kawasaki⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Wingo Shackleford⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Join the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Chapel Probation Patreon ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to support Scott and for bonus content. Join the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Chapel Probation Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ group to continue the conversations.Follow Scott on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Bluesky⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Substack⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠You can subscribe to Scott's newsletter and learn more about the book, the blog, and performances at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠rscottokamoto.com⁠

Kicking off with Real Housewives of Salt Lake City, I call out the double standard of dragging Lisa Barlow over civil suits while a cast mate's sealed alleged criminal case can't be discussed—what we know, what we don't, and why the pile-on feels lazy. Then I stitch in my conversation with James to break down Orange County's split trips: Tamra's Temecula olive branches (strategy or sincerity?), Shannon's stop-start trust, Heather's Beverly Hills night complete with a pop-up paparazzo, Gretchen's dusty studio allegations, and Gina's growing confidence. It's where both seasons actually are right now—messy, revealing, and setting the stage for Amsterdam and a spicy reunion. Watching on YouTube? Like/subscribe. Listening on audio? Drop those 5 stars.Shop my Merch!georgiotakounakis.com/shop Hosted on Acast. See acast.com/privacy for more information.

RHOSLC Ep 2 is on tonight and Lisa “Baby Gorgeous” Barlow finally returns. I react to the viral Rapture TikTok craze, and give a tight follow-up on my Grayson Entertainment/Slade deep dive after Slade Smiley popped into my comments. Plus: recording today with RHOC producer James Lee—that convo drops tomorrow alongside my SLC recap. If you're here for the goods, watch live, then meet me back here.Shop My Merch!georgiotakounakis.com/shop Hosted on Acast. See acast.com/privacy for more information.

21/09/25 | James Lee by City Church Bristol

Recently, the new embryo-selection start-up Herasight has been in the news, finally coming out of stealth. Part of the buzz is because of the public involvement of well-known geneticists and academics like Alex Young and Joe Pickrell in Herasight's algorithm development. Additionally, Noor Siddiqi, the CEO of Orchid, a competitor to Herasight (and onetime advertiser on this podcast), was a guest on Ross Douthat's show Interesting Times, triggering another round of conversations around embryo-selection, including in The Wall Street Journal and Breaking Points. To hash out some opposing viewpoints, Unsupervised Learning decided to bring on two guests that stake out very different positions, Dr. James Lee, a psychometrician and behavior geneticist at the University of Minnesota, and Dr. Jonathan Anomaly, a philosopher and Herasight's sales lead. Lee has been on the record with his skepticism of reproductive technology, writing an op-ed in The Wall Street Journal four years ago warning against the consequences of polygenic embryo selection. Meanwhile, Anomaly's last book was Creating Future People: The Science and Ethics of Genetic Enhancement, where he advances the idea that such technologies will unlock human potential.

This years Roast Summer Party at LDN East was a vibe! You all came out and partied hard! I was lucky enough to warm things up for your afternoon and get you ready for Kevin Mckay and James Lee. We started funky and ended up in the regions of tech! Let's relive that journey! ENJOY!

Happy Tuesday! It's RHOSLC Season 6 premiere night and yes—we're watching! I break down why Salt Lake keeps the bar high (editors, cast, production = clocked in) and react to the witch-hunt vibes teased in the previews. Then I share the RHOC S19 reunion seating chart predictions James Lee and I workshopped (I tweaked two seats), plus real talk on the Katie optics, Shannon's follow, and why Heather's paparazzi obsession + Beverly Hills zip code aren't giving Orange County. I revisit the Natalie (ex-assistant) angle and why casting should tap her as a friend-of. We also hit the Wife Swap: Real Housewives Edition trailer, Jersey/BH timing tea, and more Bravo buzz. We Need To Talk About This!Quick plugs - my Housewives in the Stars Tarot Deck is now shipping, new Baby Gorgeous merch is also live, and I'm on Cameo for custom jingles!Shop Merch Here: georgiotakounakis.com/shopBook a Cameo Here: https://www.cameo.com/georgiosays?srsltid=AfmBOop42RekhjJhxYNdOLQr0dYiN2je6TG7zqlHmHavwzXeU5SQ_11r Hosted on Acast. See acast.com/privacy for more information.

Enjoyed our podcast? Shoot us a text and let us know—because great conversations never end at the last word!James Lee, co-creator of Zero Unbound Art, shares his journey of blending art, music, advocacy, and technology on Tezos blockchain. Through his surreal hand-drawn animations and passion for fully on-chain formats, he's creating artwork that will outlive us all while championing accessibility and permanence in digital creation.• Converting ADHD into a creative superpower by hyperfixating on learning new skills• Building Zero Unbound Art platform to make fully on-chain NFTs accessible to everyone without coding knowledge• Creating the largest fully on-chain animation on Tezos at 261 kilobytes through hand-drawn pixel art• Living with Tourette's syndrome and discovering that creative activities help manage symptoms• Experiencing synesthesia where sounds create visual patterns that influence his artwork• Developing a 118-element periodic table animation project that combines science and art• Supporting fellow artists by collecting, amplifying, and mentoring throughout the Tezos ecosystem• Finding new creative inspiration through fatherhood and teaching his children artistic skills• Leveraging his experience as a former college professor to make blockchain technology approachableJoin us in exploring how blockchain can preserve our creative legacy forever while removing gatekeepers and giving everyone a chance to participate.

Producer James Lee reunites with me to unpack the mess in Orange County, from the New Orleans trip blow-ups to that controversial Persian New Year lie-detector scene. We dig into why the group seems set on isolating Katie, where self-advocacy could change her game, and how an off-camera “blogger” cameo scrambled alliances. Plus - Gretchen vs. Tamra hospital-gate, Slade's texts, Shannon re-follows Katie??, and how this all positions the cast heading into reunion (yes, we debate the seating chart). We also talk creator integrity in Bravo-land, why selective memory is suddenly epidemic, and what to expect as mid-season storylines pivot with Katie off most group scenes.Make sure to pre-order your "Housewives in the Stars" Tarot Deck to get FREE SHIPPING before September 15th!Visit:georgiotakounakis.com/shop Hosted on Acast. See acast.com/privacy for more information.

In Episode 3 of RHOC Season 19, Katie's apology tour goes sideways, Heather throws a belated birthday bash that spirals into chaos, and Shannon unleashes one of her most iconic exits yet. Plus, Jenn's personal life gets messier, Tamra's stirring the pot from afar, and producer James Lee is back to spill behind-the-scenes tea on everything.We Need To Talk About This! Hosted on Acast. See acast.com/privacy for more information.

Haus of GSP [07.25]00:00 - Waze & Odyssey, Tommy Theo - Always (Extended)03:30 - Las Ketchup, Mëstiza - Asereje (Remix)06:40 - Armand Van Helden - I Want Your Soul (AVH Rework)09:18 - Paris Hilton - Stay Young (Jay Hudson Remix)12:20 - Cajmere, Green Velvet, Dajae - Brighter Days (Marco Lys X WOST Mash Up)17:00 - Mau P - People Talk People Sing (Original Mix)21:14 - John Summit & Kaskade - Resonate (RAYCO Remix)25:10 - John Summit - Light years (Vandija Remix)28:10 - Paris Hilton - BBA feat. Megan Thee Stallion (Kaleena Zanders Remix)31:09 - Shakedown, Layton Giordani, Anyma (ofc) - At Night (Anyma x Layton Giordani Extended Remix)34:43 - James Lee, Thando, Charlé - Take Me Back (Extended Mix)38:17 - The Illustrious Blacks - Suck My Disco (DJ Minx Remix) (DJ Minx Remix)43:30 - Groove Armada, Gramma Funk - I See You Baby feat. Gramma Funk (Austin Ato Extended Remix)47:28 - Mau P - Like I Like It (Original Mix)52:30 - John Summit - Focus feat. CLOVES (Alok Extended Remix)56:00 - Heather Small - Proud (Josh Harris Pride Extended Remix)58:45 - Mark Knight, James Hurr - You Take Me Higher (Extended Mix)

On this episode of Georgio Says, I'm joined once again by Real Housewives of Orange County Producer James Lee to break down Season 19, Episode 2, and trust me, it's a juicy one. From Katie's olive branch to Tamra and Gretchen's explosive face-off, we unpack every moment of shade, strategy, and scandal.James answers your behind-the-scenes questions — including how production handles cast confrontations, what really happened during that shocking group dinner, and how Gina's big allegation blindsided Shannon. Plus, we get real about Emily and Shane's parenting clash and how these dynamics play out when the cameras are rolling.Whether you're Team Tamra, Team Gretchen, or just here for the chaos, this episode delivers all the drama and exclusive producer insight you can't get anywhere else. We Need To Talk About This! Hosted on Acast. See acast.com/privacy for more information.

James Lee, Real Housewives of Orange County producer, is back with me to kick off our exclusive Season 19 recaps! We're breaking down the premiere episode, “Revolving Door of Lies”, and James is answering some of your burning questions about what really went down behind the scenes.

Dr. James Lee of Concordia University Chicago Concordia University Chicago School of Theology The post The Athanasian Creed – Dr. James Lee, 6/16/25 (1673, Encore) first appeared on Issues, Etc..

In this eye-opening episode, Reinette Senum and geoengineering researcher James Lee reveal how nearly everything we've been told online about geoengineering is misleading or outright false. They break down the real science behind weather modification, clarifying the confusion between chemtrails, contrails, aircraft capabilities, and atmospheric intervention. This episode peels back the layers of disinformation to expose the truth about what's happening in our skies—and why it matters. Senum and Lee also discuss their pending lawsuit aimed at demanding transparency and accountability, and share how listeners can begin to understand and take action on this critical issue. Learn more on their websites at https://ReinetteSenumsFogHornExpress.substack.com or at https://Connect.climateviewer.com

Everything you Know about Geoengineering is Wrong w/ Reinette Senum and Jim Lee - SarahWestall.com

Is your loved one in a memory care community, or are you considering moving them into one? Understanding how to build a collaborative relationship with the care team is crucial for ensuring the best outcomes for your loved one. We are Sue Ryan and Nancy Treaster. As caregivers for our loved ones with Alzheimer's and other types of dementia, we've learned that creating a true partnership with care community staff can dramatically improve quality of care and reduce stress for everyone involved. We recently spoke with James Lee, CEO and co-founder of Bella Groves, an award-winning memory care community. With over 17 years of experience in senior living and memory care, James has developed valuable insights on how to transform what is often an adversarial relationship between family caregivers and professional caregivers into a collaborative partnership. Full Show Notes https://thecaregiversjourney.org/35-build-a-partnership-with-your-care-community-six-essential-tips-alzheimers-and-other-dementias/ Additional Resources Mentioned Support the nonprofit The Caregiver's Journey: https://give.cornerstone.cc/thecaregiversjourney Takeaways Tip 1: Assess the Overall Fit When looking for a memory care community, many families focus on practical aspects like location, price, and amenities. While these factors are important, James suggests that philosophical alignment and rapport with the management team are even more crucial for long-term success. When evaluating potential communities, James recommends shifting your mindset from "us versus them" to "us collectively versus dementia." This perspective can transform the relationship from the beginning. Tip 2: Embrace the Community Aspect Moving your loved one from home to a community setting represents a fundamental shift in their care environment—from one-on-one care to being part of a group. Tip 3: Acknowledge Your Role Has Changed When your loved one moves into a care community, your role shifts from being the primary caregiver to being a care partner working alongside professional caregivers. Tip 4: Recognize That the Diagnosis Will Progress A critical aspect of the care partnership is understanding that your loved one's condition will continue to change over time. In fact, by the time someone moves into a memory care community, they're often in the steeper part of their dementia journey where changes happen more rapidly. Tip 5: Acknowledge Your Grief The dementia journey involves ongoing loss, a phenomenon Sue calls "drip grief." As your loved one's condition progresses, you experience new losses almost daily—abilities that disappear, memories that fade, personality changes that emerge. Tip 6: Engage with the Community Caregiving Team The families whose loved ones have the best quality of life tend to be those who actively engage with the care team. This engagement goes beyond basic communication to building genuine relationships with the people caring for your loved one. Building a True Partnership Creating a collaborative relationship with your loved one's care community team isn't just about being nice—it's about achieving the best possible outcomes for your loved one with dementia. By reframing the relationship from "us versus them" to "us collectively versus dementia," you can transform what is often an adversarial dynamic into a true partnership. As James explains, "You are your loved one's expert, we are dementia experts. And the two together give us the best chance to get this right." Read More in This Blog here

MOVE SUPPLY CHAINPay less for COGS, get shorter lead times, and improve payment terms in your supply chain with help from Move Supply Chain at https://⁠movesupplychain.com⁠.INTELLIGEMSIntelligems is the ultimate profit-optimization tool for DTC brands. Use it for all of your CRO efforts by visiting https://intelligems.io.//Reach out to James Lee on X at https://x.com/jameshyujinlee to get started with overseas product photography.Get my complete guide to Target ROAS bidding here: https://www.youtube.com/watch?v=V_7SbiBun10//What separates the most profitable eCommerce operators from the rest?In this episode, Andrew breaks down 5 underutilized tactics that high-performing 7–9 figure brands are using to grow faster, retain customers longer, and increase margins—without adding risk.From low-MOQ product launches to price testing that lifts per-visitor profit, to smarter Meta bidding strategies and supply chain overhauls, this episode is packed with actionable insights. If your brand is stuck at a growth plateau, or bleeding margin from inefficiencies, this is the roadmap you've been looking for.You'll walk away with a clear, tested list of what's working right now—and where you might be leaving serious money on the table.//CHAPTER TITLES:00:22 - Not Launching Enough Products8:21 - Lower Cost of Product Launch15:33 - Price Testing18:08 - Target ROAS Campaigns21:43 - Supply Chain Management28:05 - Brand Marketing// SUBSCRIBE TO MY CHANNEL FOR 2X WEEKLY UPLOADS!//ADMISSIONGet the best media buying training on the Internet + a free coaching call with Common Thread Collective's media buyers when you sign up for ADmission here: https://www.youradmission.co/andrew-faris-podcast//FOLLOW UP WITH ANDREW X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/andrewjfaris Email: podcast@ajfgrowth.comWork with Andrew: https://ajfgrowth.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Welcome back to the Identity Theft Resource Center's Weekly Breach Breakdown – supported by Sentilink. I'm James Lee, the ITRC's President and this is the episode for May 2nd, 2025. Future U.S. president John Adams was defending British soldiers accused of opening fire on protesters in what would become known as the Boston Massacre before the American Revolution. In his defense, which was successful, he wrote: “Facts are stubborn things.” As was true in 1770, is still true today. Follow on LinkedIn: www.linkedin.com/company/idtheftcenter/ Follow on X: twitter.com/IDTheftCenter

Therapy Sessions Ep. 58 TRACKLIST1) Leon Benesty - Not A Game (Original Mix) [Summer-ized Sessions]2) TOBEHONEST - Hey Ya (Extended Mix) [Insomniac Records]3) Daniel Steinberg - Sacrifice (Extended Mix) [Arms & Legs]4) Alex Imperiale - All You Need (Extended Mix) [Toolroom Trax]5) Bessey - Alert (Extended Mix) [KNOW WHERE]6) Dario Nunez - Let The Groove (Extended Mix) [Toolroom Trax]7) Axwell - I Found You - Wh0 Festival Remix (Extended Mix) 8) Tommy Mambretti - Stronger (Original Mix) [Cube Recordings]9) Leon Benesty, Vinny James - Everybody is Equal (Original Mix)10) David Guetta, Tom Enzy, Juany Bravo, Jaden Bojsen, Sami Brielle - Let's Go [HUGEL Remix] (feat. Tom Enzy, Juany Bravo & Sami Brielle) [SPINNIN' RECORDS]11) Nolek - Tambores (Original Mix) [HoTL Records]12) Tom Bug, Grooveline - Dizzy (Original Mix) [REK'D]13) Tiger Stripes - All Night Long (Extended) [TRIP AND BASS Records]14) Thando, James Lee, Charle - Take Me Back (Extended Mix) [Glasgow Underground]15) Revival House Project, Kathy Brown & David Penn - Dance to the Music (David Penn Remix [Extended]) [Revival Records Ltd]16) Tony Cortez - La Murga (Extended Mix) [Golden Recordings]17) All Fred - Ritmo Cubano (Extended Mix) [Cha Cha Groove Records]18) Mike Newman - My Lovin' (Mike Newman Mix)

To get live links to the music we play and resources we offer, visit www.WOSPodcast.comThis show includes the following songs:Reanne - This Body FOLLOW ON SPOTIFYCamryn Quinlan - Ex Box FOLLOW ON SPOTIFYEmma Mowery - erased me FOLLOW ON SPOTIFYMalene Markussen - Calling FOLLOW ON SPOTIFYNadia Vaeh - R!OT FOLLOW ON SPOTIFYAmber Ais - Love Yourself FOLLOW ON SPOTIFYSara Diana - The Villain FOLLOW ON SPOTIFYCordelia Chatfield - Train Ride Home FOLLOW ON SPOTIFYAyla XO - Between The Cheats FOLLOW ON SPOTIFYTasha Ann - When the Waters Rise FOLLOW ON SPOTIFYOnism E - Call You Home FOLLOW ON SPOTIFYJames Lee Johnston - Winter Moon FOLLOW ON SPOTIFYLand Of Bees - Falling Skies FOLLOW ON SPOTIFYLouisa Love - Light in the Dark FOLLOW ON SPOTIFYIurisEkero - Midnight Drive FOLLOW ON SPOTIFYFor Music Biz Resources Visit www.FEMusician.com and www.ProfitableMusician.comVisit our Sponsor Profitable Musician Newsletter at profitablemusician.com/joinVisit our Sponsor Kick Bookkeeping at http://profitablemusician.com/kickVisit our Sponsor Track Stage at https://profitablemusician.com/trackstageVisit www.wosradio.com for more details and to submit music to our review board for consideration.Visit our resources for Indie Artists: https://www.wosradio.com/resourcesBecome more Profitable in just 3 minutes per day. http://profitablemusician.com/join

Episode 45 - Reclaim Your Vitality - After a health crisis left Dr. James Lee unable to speak or work, he and his wife created Liveli - a revolutionary system that restored him to 100 percent and helps others perform their best. Disclaimer: Please note that all information and content on the UK Health Radio Network, all its radio broadcasts and podcasts are provided by the authors, producers, presenters and companies themselves and is only intended as additional information to your general knowledge. As a service to our listeners/readers our programs/content are for general information and entertainment only.  The UK Health Radio Network does not recommend, endorse, or object to the views, products or topics expressed or discussed by show hosts or their guests, authors and interviewees.  We suggest you always consult with your own professional – personal, medical, financial or legal advisor. So please do not delay or disregard any professional – personal, medical, financial or legal advice received due to something you have heard or read on the UK Health Radio Network.

PART ONE - THE LOVE HOUSE LOCKDOWN Chaka's Forever Lasting Night - Block & Crown & Lissat Get Down (Extended Club Mix) - Sebb Junior Disco Stuff (Jay Vegas Classic Disco Extended Mix) - Daniel Dash The Word Is Love (Say the Word) [Silk's Anthem of Life] - Voices Of Life Smalltown Boy (feat. Colin) (Nu Disco Mix) - Colin, Block & Crown Let the Music Play (Extended Mix) - Ghostbusterz We Love House Music - Block & Crown Happy Days (Classic Club Mix) - Jay Vegas Dreamstate (Extended Mix) - Kevin McKay, Giovanni Lucchetti, Abigail Smiths Second Time Around (Extended Mix) - Daniel Steinberg Walking on a Dream (Extended Mix) - Sean Finn Chicky Groove - Crazibiza, Jaxx Inc. & Alex Peace Believe (Sandro Puddu Remix) - Richard Grey Zapata (Extended Mix) - Illyus & Barrientos Big Love (David Penn Extended Remix) - Pete Heller's Big Love PART TWO - THE SESSION Work This (Extended Mix) - Sowel Your Body (Cheesecake Boys, Discoteca Remix) - Babes on the Run, Discoteca The Funk (Extended Mix) - Wh0  You Get Down (Extended Mix) - James Hurr Vitamin E - Tigerblind She The Last One - Vintage Culture, ARTBAT Give Me Desire (Extended Mix) - Alex Mills, ESSEL Inferno - Max Styler Check My Brain - Black V Neck Bus Stop Please - Fatboy Slim, Daniel Steinberg Heat (Hot Since 82 Extended Mix) - Prunk Dark Side (Extended Mix) - Qubiko Take Me Back (Extended Mix) - Thando, James Lee, Charle  Act A Fool (Extended Mix) - Charlie Powell Filthy (Extended Mix) - Diego Barrera

In Case No. 1:23-mj-04605-DHH, Special Agent Zachary A. Mitlitsky of Homeland Security Investigations (HSI) submitted an affidavit supporting a criminal complaint against Han Lee, James Lee, and Junmyung Lee. The affidavit outlines an extensive investigation revealing that, since at least July 2020, the defendants operated an interstate prostitution network with brothels in the greater Boston area and eastern Virginia. They advertised these illicit services through websites masquerading as professional nude modeling platforms, such as www.bostontopten10.com and www.browneyesgirlsva.blog. The operation involved renting high-end apartments where recruited women engaged in commercial sex acts for cash. The defendants facilitated these activities by arranging transportation, managing appointments via dedicated phone lines, and maintaining the brothel locations. Financial records indicate that Han Lee, identified as the leader, concealed over a million dollars in prostitution proceeds through structured money orders, cash deposits, and various bank transfers. James and Junmyung Lee assisted by leasing apartments under their names or aliases and handling day-to-day operations, including transporting the women and collecting proceeds. The affidavit provides detailed evidence of their roles and the methods employed to sustain and conceal the prostitution enterprise.to contact me:bobbycapucci@protonmail.comsource:USA v. Han Lee, et al - Complaint Affidavit

In Case No. 1:23-mj-04605-DHH, Special Agent Zachary A. Mitlitsky of Homeland Security Investigations (HSI) submitted an affidavit supporting a criminal complaint against Han Lee, James Lee, and Junmyung Lee. The affidavit outlines an extensive investigation revealing that, since at least July 2020, the defendants operated an interstate prostitution network with brothels in the greater Boston area and eastern Virginia. They advertised these illicit services through websites masquerading as professional nude modeling platforms, such as www.bostontopten10.com and www.browneyesgirlsva.blog. The operation involved renting high-end apartments where recruited women engaged in commercial sex acts for cash. The defendants facilitated these activities by arranging transportation, managing appointments via dedicated phone lines, and maintaining the brothel locations. Financial records indicate that Han Lee, identified as the leader, concealed over a million dollars in prostitution proceeds through structured money orders, cash deposits, and various bank transfers. James and Junmyung Lee assisted by leasing apartments under their names or aliases and handling day-to-day operations, including transporting the women and collecting proceeds. The affidavit provides detailed evidence of their roles and the methods employed to sustain and conceal the prostitution enterprise.to contact me:bobbycapucci@protonmail.comsource:USA v. Han Lee, et al - Complaint Affidavit

In Case No. 1:23-mj-04605-DHH, Special Agent Zachary A. Mitlitsky of Homeland Security Investigations (HSI) submitted an affidavit supporting a criminal complaint against Han Lee, James Lee, and Junmyung Lee. The affidavit outlines an extensive investigation revealing that, since at least July 2020, the defendants operated an interstate prostitution network with brothels in the greater Boston area and eastern Virginia. They advertised these illicit services through websites masquerading as professional nude modeling platforms, such as www.bostontopten10.com and www.browneyesgirlsva.blog. The operation involved renting high-end apartments where recruited women engaged in commercial sex acts for cash. The defendants facilitated these activities by arranging transportation, managing appointments via dedicated phone lines, and maintaining the brothel locations. Financial records indicate that Han Lee, identified as the leader, concealed over a million dollars in prostitution proceeds through structured money orders, cash deposits, and various bank transfers. James and Junmyung Lee assisted by leasing apartments under their names or aliases and handling day-to-day operations, including transporting the women and collecting proceeds. The affidavit provides detailed evidence of their roles and the methods employed to sustain and conceal the prostitution enterprise.to contact me:bobbycapucci@protonmail.comsource:USA v. Han Lee, et al - Complaint Affidavit

In Case No. 1:23-mj-04605-DHH, Special Agent Zachary A. Mitlitsky of Homeland Security Investigations (HSI) submitted an affidavit supporting a criminal complaint against Han Lee, James Lee, and Junmyung Lee. The affidavit outlines an extensive investigation revealing that, since at least July 2020, the defendants operated an interstate prostitution network with brothels in the greater Boston area and eastern Virginia. They advertised these illicit services through websites masquerading as professional nude modeling platforms, such as www.bostontopten10.com and www.browneyesgirlsva.blog. The operation involved renting high-end apartments where recruited women engaged in commercial sex acts for cash. The defendants facilitated these activities by arranging transportation, managing appointments via dedicated phone lines, and maintaining the brothel locations. Financial records indicate that Han Lee, identified as the leader, concealed over a million dollars in prostitution proceeds through structured money orders, cash deposits, and various bank transfers. James and Junmyung Lee assisted by leasing apartments under their names or aliases and handling day-to-day operations, including transporting the women and collecting proceeds. The affidavit provides detailed evidence of their roles and the methods employed to sustain and conceal the prostitution enterprise.to contact me:bobbycapucci@protonmail.comsource:USA v. Han Lee, et al - Complaint Affidavit

In Case No. 1:23-mj-04605-DHH, Special Agent Zachary A. Mitlitsky of Homeland Security Investigations (HSI) submitted an affidavit supporting a criminal complaint against Han Lee, James Lee, and Junmyung Lee. The affidavit outlines an extensive investigation revealing that, since at least July 2020, the defendants operated an interstate prostitution network with brothels in the greater Boston area and eastern Virginia. They advertised these illicit services through websites masquerading as professional nude modeling platforms, such as www.bostontopten10.com and www.browneyesgirlsva.blog. The operation involved renting high-end apartments where recruited women engaged in commercial sex acts for cash. The defendants facilitated these activities by arranging transportation, managing appointments via dedicated phone lines, and maintaining the brothel locations. Financial records indicate that Han Lee, identified as the leader, concealed over a million dollars in prostitution proceeds through structured money orders, cash deposits, and various bank transfers. James and Junmyung Lee assisted by leasing apartments under their names or aliases and handling day-to-day operations, including transporting the women and collecting proceeds. The affidavit provides detailed evidence of their roles and the methods employed to sustain and conceal the prostitution enterprise.to contact me:bobbycapucci@protonmail.comsource:USA v. Han Lee, et al - Complaint AffidavitBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

In Case No. 1:23-mj-04605-DHH, Special Agent Zachary A. Mitlitsky of Homeland Security Investigations (HSI) submitted an affidavit supporting a criminal complaint against Han Lee, James Lee, and Junmyung Lee. The affidavit outlines an extensive investigation revealing that, since at least July 2020, the defendants operated an interstate prostitution network with brothels in the greater Boston area and eastern Virginia. They advertised these illicit services through websites masquerading as professional nude modeling platforms, such as www.bostontopten10.com and www.browneyesgirlsva.blog. The operation involved renting high-end apartments where recruited women engaged in commercial sex acts for cash. The defendants facilitated these activities by arranging transportation, managing appointments via dedicated phone lines, and maintaining the brothel locations. Financial records indicate that Han Lee, identified as the leader, concealed over a million dollars in prostitution proceeds through structured money orders, cash deposits, and various bank transfers. James and Junmyung Lee assisted by leasing apartments under their names or aliases and handling day-to-day operations, including transporting the women and collecting proceeds. The affidavit provides detailed evidence of their roles and the methods employed to sustain and conceal the prostitution enterprise.to contact me:bobbycapucci@protonmail.comsource:USA v. Han Lee, et al - Complaint AffidavitBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

In Case No. 1:23-mj-04605-DHH, Special Agent Zachary A. Mitlitsky of Homeland Security Investigations (HSI) submitted an affidavit supporting a criminal complaint against Han Lee, James Lee, and Junmyung Lee. The affidavit outlines an extensive investigation revealing that, since at least July 2020, the defendants operated an interstate prostitution network with brothels in the greater Boston area and eastern Virginia. They advertised these illicit services through websites masquerading as professional nude modeling platforms, such as www.bostontopten10.com and www.browneyesgirlsva.blog. The operation involved renting high-end apartments where recruited women engaged in commercial sex acts for cash. The defendants facilitated these activities by arranging transportation, managing appointments via dedicated phone lines, and maintaining the brothel locations. Financial records indicate that Han Lee, identified as the leader, concealed over a million dollars in prostitution proceeds through structured money orders, cash deposits, and various bank transfers. James and Junmyung Lee assisted by leasing apartments under their names or aliases and handling day-to-day operations, including transporting the women and collecting proceeds. The affidavit provides detailed evidence of their roles and the methods employed to sustain and conceal the prostitution enterprise.to contact me:bobbycapucci@protonmail.comsource:USA v. Han Lee, et al - Complaint AffidavitBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

In Case No. 1:23-mj-04605-DHH, Special Agent Zachary A. Mitlitsky of Homeland Security Investigations (HSI) submitted an affidavit supporting a criminal complaint against Han Lee, James Lee, and Junmyung Lee. The affidavit outlines an extensive investigation revealing that, since at least July 2020, the defendants operated an interstate prostitution network with brothels in the greater Boston area and eastern Virginia. They advertised these illicit services through websites masquerading as professional nude modeling platforms, such as www.bostontopten10.com and www.browneyesgirlsva.blog. The operation involved renting high-end apartments where recruited women engaged in commercial sex acts for cash. The defendants facilitated these activities by arranging transportation, managing appointments via dedicated phone lines, and maintaining the brothel locations. Financial records indicate that Han Lee, identified as the leader, concealed over a million dollars in prostitution proceeds through structured money orders, cash deposits, and various bank transfers. James and Junmyung Lee assisted by leasing apartments under their names or aliases and handling day-to-day operations, including transporting the women and collecting proceeds. The affidavit provides detailed evidence of their roles and the methods employed to sustain and conceal the prostitution enterprise.to contact me:bobbycapucci@protonmail.comsource:USA v. Han Lee, et al - Complaint AffidavitBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

In November 2023, federal authorities arrested three individuals—Han Lee, James Lee, and Junmyung Lee—for allegedly operating a sophisticated high-end prostitution network spanning the greater Boston area and eastern Virginia. The network reportedly catered to a clientele that included elected officials, military officers, high-tech and pharmaceutical executives, doctors, government contractors with security clearances, professors, attorneys, scientists, and accountants. The operation involved renting luxury apartments in locations such as Cambridge and Watertown, Massachusetts, as well as Fairfax and Tysons, Virginia, which were used as brothels. The defendants advertised their services through websites like bostontopten10.com and browneyesgirlsva.blog, which purported to offer professional photography sessions with nude Asian models as a front for prostitution. Clients were subjected to a thorough vetting process, requiring them to provide personal information, including employer details and references, before booking appointments.In September 2024, Han Lee pleaded guilty to charges of conspiracy to persuade individuals to travel interstate for prostitution and money laundering. She admitted to managing the network, coordinating travel and accommodations for primarily Asian women, and concealing over $1 million in proceeds through various means, including converting cash into money orders. Following her plea, co-defendant Junmyung Lee also pleaded guilty to similar charges in October 2024, acknowledging his role as a booking agent for the network. Despite the high-profile nature of the clientele, authorities have not publicly disclosed the identities of the clients, nor have any clients been charged. The women involved in the operation have been treated as victims and were not criminally charged. Sentencing for Han Lee is scheduled for December 20, 2024, where she faces up to 25 years in prison.(commercialat 8:01)to contact me:bobbycapucci@protonmail.comsource:High-end sex ring in Boston and D.C. areas was 'honeypot' scheme by Russia, China, South Korea or even Israel - to ensnare US officials, intelligence experts believe | Daily Mail Online

In November 2023, federal authorities arrested three individuals—Han Lee, James Lee, and Junmyung Lee—for allegedly operating a sophisticated high-end prostitution network spanning the greater Boston area and eastern Virginia. The network reportedly catered to a clientele that included elected officials, military officers, high-tech and pharmaceutical executives, doctors, government contractors with security clearances, professors, attorneys, scientists, and accountants. The operation involved renting luxury apartments in locations such as Cambridge and Watertown, Massachusetts, as well as Fairfax and Tysons, Virginia, which were used as brothels. The defendants advertised their services through websites like bostontopten10.com and browneyesgirlsva.blog, which purported to offer professional photography sessions with nude Asian models as a front for prostitution. Clients were subjected to a thorough vetting process, requiring them to provide personal information, including employer details and references, before booking appointments.In September 2024, Han Lee pleaded guilty to charges of conspiracy to persuade individuals to travel interstate for prostitution and money laundering. She admitted to managing the network, coordinating travel and accommodations for primarily Asian women, and concealing over $1 million in proceeds through various means, including converting cash into money orders. Following her plea, co-defendant Junmyung Lee also pleaded guilty to similar charges in October 2024, acknowledging his role as a booking agent for the network. Despite the high-profile nature of the clientele, authorities have not publicly disclosed the identities of the clients, nor have any clients been charged. The women involved in the operation have been treated as victims and were not criminally charged. Sentencing for Han Lee is scheduled for December 20, 2024, where she faces up to 25 years in prison.(commercialat 8:01)to contact me:bobbycapucci@protonmail.comsource:High-end sex ring in Boston and D.C. areas was 'honeypot' scheme by Russia, China, South Korea or even Israel - to ensnare US officials, intelligence experts believe | Daily Mail Online

In November 2023, federal authorities arrested three individuals—Han Lee, James Lee, and Junmyung Lee—for allegedly operating a sophisticated high-end prostitution network spanning the greater Boston area and eastern Virginia. The network reportedly catered to a clientele that included elected officials, military officers, high-tech and pharmaceutical executives, doctors, government contractors with security clearances, professors, attorneys, scientists, and accountants. The operation involved renting luxury apartments in locations such as Cambridge and Watertown, Massachusetts, as well as Fairfax and Tysons, Virginia, which were used as brothels. The defendants advertised their services through websites like bostontopten10.com and browneyesgirlsva.blog, which purported to offer professional photography sessions with nude Asian models as a front for prostitution. Clients were subjected to a thorough vetting process, requiring them to provide personal information, including employer details and references, before booking appointments.In September 2024, Han Lee pleaded guilty to charges of conspiracy to persuade individuals to travel interstate for prostitution and money laundering. She admitted to managing the network, coordinating travel and accommodations for primarily Asian women, and concealing over $1 million in proceeds through various means, including converting cash into money orders. Following her plea, co-defendant Junmyung Lee also pleaded guilty to similar charges in October 2024, acknowledging his role as a booking agent for the network. Despite the high-profile nature of the clientele, authorities have not publicly disclosed the identities of the clients, nor have any clients been charged. The women involved in the operation have been treated as victims and were not criminally charged. Sentencing for Han Lee is scheduled for December 20, 2024, where she faces up to 25 years in prison.(commercialat 8:01)to contact me:bobbycapucci@protonmail.comsource:High-end sex ring in Boston and D.C. areas was 'honeypot' scheme by Russia, China, South Korea or even Israel - to ensnare US officials, intelligence experts believe | Daily Mail OnlineBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

In November 2023, federal authorities arrested three individuals—Han Lee, James Lee, and Junmyung Lee—for allegedly operating a sophisticated high-end prostitution network spanning the greater Boston area and eastern Virginia. The network reportedly catered to a clientele that included elected officials, military officers, high-tech and pharmaceutical executives, doctors, government contractors with security clearances, professors, attorneys, scientists, and accountants. The operation involved renting luxury apartments in locations such as Cambridge and Watertown, Massachusetts, as well as Fairfax and Tysons, Virginia, which were used as brothels. The defendants advertised their services through websites like bostontopten10.com and browneyesgirlsva.blog, which purported to offer professional photography sessions with nude Asian models as a front for prostitution. Clients were subjected to a thorough vetting process, requiring them to provide personal information, including employer details and references, before booking appointments.In September 2024, Han Lee pleaded guilty to charges of conspiracy to persuade individuals to travel interstate for prostitution and money laundering. She admitted to managing the network, coordinating travel and accommodations for primarily Asian women, and concealing over $1 million in proceeds through various means, including converting cash into money orders. Following her plea, co-defendant Junmyung Lee also pleaded guilty to similar charges in October 2024, acknowledging his role as a booking agent for the network. Despite the high-profile nature of the clientele, authorities have not publicly disclosed the identities of the clients, nor have any clients been charged. The women involved in the operation have been treated as victims and were not criminally charged. Sentencing for Han Lee is scheduled for December 20, 2024, where she faces up to 25 years in prison.(commercialat 8:01)to contact me:bobbycapucci@protonmail.comsource:High-end sex ring in Boston and D.C. areas was 'honeypot' scheme by Russia, China, South Korea or even Israel - to ensnare US officials, intelligence experts believe | Daily Mail OnlineBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-epstein-chronicles--5003294/support.

Singaporean actor, director, martial artist, stuntman and fight choreographer Sunny Pang has appeared is such films as The Night Comes for Us (2018), Buffalo Boys (2018), Diamond Dogs (2017), The Collector (2012), Exiled: The Chosen Ones (2024), and the upcoming Havoc; written and directed by Gareth Evans and starring Tom Hardy,Timothy Olyphant and Forest Whitaker. Sunny's career in action film spans over 20 years. He is the founder of the Ronin Action Team. In this interview we break down the epic eleven-minute finale fight with Iko Uwais (The Raid) from Headshot (2016). Sunny shares his history with martial arts, the film industry, views on storytelling and some very funny humor! Sit back and enjoy this fantastic interview!Sunny's Website: https://www.cinderama.com/Sunny's IMDB: https://www.imdb.com/name/nm1837651/Sunny's Instagram: https://www.instagram.com/sunnypang72/Ronin Action: https://www.instagram.com/roninaction/MENTIONSHeadshot Finale Fight with Iko Uwais and Sunny Pang: https://youtu.be/5cWA1To62lU?si=ZfZQ6zC5yJr2ELKtIKO UWAIS & SUNNY PANG Fight!!! | TIFF 2016: https://www.youtube.com/watch?v=WYtK-ZKkSf4Last Supper [Action Short Film] Sunny Pang and James Lee (2012): https://www.youtube.com/watch?v=RTylrKix8lkThe Collector 收烂数 [Action & Fight Test]: https://www.youtube.com/watch?v=wRGB8rB7rs0In the Bedroom of the Mountain King (2022): https://youtu.be/PRvsjT_nrB0?si=ERMl-5fc4xuE9FXFThree Days of Grace (2015): https://youtu.be/a-tAwYf-RTM?si=plskb7zd1xWxeaeGCall If You Need Me [黑夜行路] by James Lee (2022): https://youtu.be/JrRmj9xfsZU?si=ccLIdj4Eh7tG38y0FILM FIGHTS WITH FRIENDSDo you listen to our show as an audio podcast? Give video a try. Subscribe to our Youtube for the video version with awesome behind the scenes pics and video! https://www.youtube.com/@FilmFightsFriendsPod?sub_confirmation=1Dig the show? Consider supporting our Patreon. There are some cool perks! Patreon: http://patreon.com/FilmFightsFriendsPod Join our e-mail list! Hit us up here: fightingwithfriends@gmail.comInstagram: http://instagram.com/FilmFightsFriendsPodFacebook: http://facebook.com/FilmFightsFriendsPodSteve's Instagram: http://Instagram.com/sambosteve Steve's IMDB:

In this episode, James Lee, CFO of MultiCare Health System, discusses key healthcare trends for 2025, including the aging population's impact, workforce challenges, and technology adoption. He also highlights MultiCare's efforts to improve employee retention, manage patient access, and strategically grow amid evolving market conditions.

We kicked off the program with four news stories and different guests on the stories we think you need to know about!Dr. Simone Alicia, award-winning motivational speaker and international personal development expert explained how to cope with mass destruction, such as the case with the CA wildfires where people are experiencing losing their homes and all they have.James Lee, President of the Identity Theft Resource Center, discussed facing the App-ocalypse – How to Delete Apps to Protect Your Identity.Dr. Bonnie Halpern-Felsher on trends in teen nicotine use and how it's very popular. 8 percent of high schoolers (1.2 million teens) report that they use e-cigarettes.Norbert Heuser - a health and wellness educator, entrepreneur, and author explained what 5G technology is. RFK Jr.'s Strong Stand Against 5G Dangers: What He's Fighting For and How You Can Help Keep Your Family Safe.Ask Alexa to play WBZ NewsRadio on #iHeartRadio and listen to NightSide with Dan Rea Weeknights From 8PM-12AM!