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Each week, I ask my guest five questions designed to nourish their mind, body, and soul pre interview. These questions help us explore what makes each guest tick as an imperfect, evolving human, taking them out of their heads and into their bodies.While our discussions often go deep into the intellect, these questions invite my guests to step out of their comfort zones, gain a fresh perspective, and perhaps hold a bit more compassion for themselves. I believe this shift from headspace to heart space is something we can all relate to – it's the universal journey of being human.And as a listener, I hope you'll come away feeling a little more connected, not only to these stories but to the shared truths and vulnerabilities we uncover here. Each conversation is an opportunity to peek behind the scenes and share in the humanity of those on the other side of the microphone.Third - Clinical Lead in Adult and Pediatric Allergy, Professor Gideon Lack.Listen to the full episode here.Watch the full episode on YouTube here.***Thank you to my wonderful sponsors! VivoBarefoot | 'If you can't be barefoot, be Vivobarefoot'For 20% off, use code LWBW20www.vivobarefoot.comOneSkin | Topical Products for Healthy Aginghttp://oneskin.co/LWBWUse code LWBW for 15% off your first order ***If you enjoyed this episode you might also like:No.1 Gut Scientist: Insane Fiber Benefits to HEAL YOUR GUT & Beat Disease | Dr Will Bulsiewiczhttps://youtu.be/8X3b4Hzq75k?si=5QkLtuNL4QuK8NLCDr. William Li: Can Diet DAMAGE Your Blood Brain Barrier?https://youtu.be/UrCxdniSLiU?si=axPm-SE6AG0hGKJ1Stanford-trained physician: 5 Nutrients That SUPERCHARGE Your Cells (And Why It Matters)https://youtu.be/rFz1WTPMdBE?si=EXJUWh-liuXkmhEK***Sign up to Sarah's Compassionate Cure newsletter: Science Simplified, Health Humanised. Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahmacklin.substack.com/***Let's be friends!
Description: Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Dr. Wayne Shreffler, Chief of Pediatric Allergy and Immunology and Co-Director of The Food Allergy Center at Massachusetts General Hospital. Dr. Shreffler is also an investigator at The Center for Immunology and Inflammatory Disease and The Food Allergy Science Initiative. His research is focused on understanding how adaptive immunity to dietary antigens is both naturally regulated and modulated by therapy in the context of food allergy. This interview covers the results of a research paper on The Intersection of Food Allergy and Eosinophilic Esophagitis, co-authored by Dr. Shreffler. Disclaimer: The information provided in this podcast is designed to support, not replace the relationship that exists between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own. Key Takeaways: [:50] Co-host Ryan Piansky introduces the episode, brought to you thanks to the support of Education Partners Bristol Myers Squibb, GSK, Sanofi, and Regeneron. Ryan introduces co-host, Holly Knotowicz. [1:15] Holly introduces today's topic, the intersection of food allergy and eosinophilic esophagitis. [1:26] Holly introduces today's guest, Dr. Wayne Shreffler, Chief of Pediatric Allergy and Immunology and Co-Director of The Food Allergy Center at Massachusetts General Hospital and an investigator at The Center for Immunology and Inflammatory Disease and The Food Allergy Science Initiative. [1:43] Dr. Shreffler's research is focused on understanding how adaptive immunity to dietary antigens is both naturally regulated and modulated by therapy in the context of food allergy. [1:54] Holly welcomes Dr. Shreffler to Real Talk. When Holly moved to Maine, she sent her patients to Dr. Shreffler at Mass General. [2:25] Dr. Shreffler trained in New York on a Ph.D. track. He was interested in parasitic diseases and the Th2 immune response. Jane Curtis, a program director at Albert Einstein College of Medicine, encouraged him to consider MD/PhD programs. He did. [3:31] Jane Curtis connected him to Hugh Sampson, who was working with others to help understand the clinical prevalence of food allergy and allergens. [3:51] As a pediatric resident, Dr. Shreffler had seen the burden of allergic disease, caring for kids in the Bronx with asthma. His interest in Th2 immunity, the clear and compelling unmet clinical need, and the problem of food allergy guided his career. [4:31] Dr. Shreffler's wife has food allergies and they were concerned for their children. Fortunately, neither of them developed food allergies. [5:21] Dr. Shreffler thinks the food allergy field has a lot of people who gravitate toward it for personal reasons. [5:53] Food allergy is an adverse response to food that is immune-mediated. There is still uncertainty about this but Dr. Shreffler believes that a large percentage of patients with EoE have some triggers that are food antigens. [6:27] The broad definition of food allergy would include things like food protein-induced enterocolitis syndrome (FPIES). [6:47] The way we use the term food allergy in the clinic, there are two forms: IgE-mediated allergies and non-IgE-mediated allergies, including EoE. [7:40] Some patients have food-triggered eczema, some have FPIES. [8:04] In 2024, Dr. Shreffler and Dr. Caitlin Burk released a paper that looked at the triggers of EoE, particularly the intersection of IgE-mediated food allergy and EoE. [8:41] Dr. Caitlin Burk joined the group as they were publishing papers on IG food allergy and EoE. It was a moment where things unexpectedly came together. [9:17] Adaptive immunity to food proteins comes from antibodies that cause milk allergy, egg allergy, peanut allergy, or multiple allergies. The IgE has specificity. [9:40] T cells also are specific to proteins. They express a host of receptors that recognize almost anything the immune system might encounter. They have a long memory like B-cells. [10:09] The overlap in these two threads of research was regarding a population of T cells that are important for mediating chronic inflammation at epithelial sites, including the gut. [10:36] These T cells have been described in the airways in asthma, in the skin in eczema, and the GI tract. Researchers years ago had also described them as being associated with IgE food allergy. People with IgE food allergies avoid allergens. [11:13] T cells, being associated with chronic allergic inflammation, now being associated with food allergies which are not having chronic exposures to the allergen, was interesting and surprising. [11:30] Dr. Shreffler and his group found the T cell subset in patients who don't do well with Oral Immunotherapy (OIT) and patients who have EoE with immediate symptoms. [12:01] Dr. Shreffler notes differences. There are immediate symptoms of IgE food allergy. There is a subset of patients with EoE who have immediate symptoms that are not fully understood. Maybe IgE plays a role there. [12:28] There are different mechanisms for how symptoms are caused and so different ways of making a diagnosis. A food allergy with an IgE antibody can be measured through skin tests and blood tests. This can help identify which foods are the trigger. [12:57] This common T cell subset that we see in EoE and food allergy, helps to explain why IgE alone is not always a very specific marker for identifying people who will have immediate reactions when they're exposed to the food. [13:17] For patients who react at low levels, it's not just that they have more or better IgE but they also have an expansion of these T cells that are common between EoE and other chronic forms of allergy and IgE food allergy. [13:41] There's a lot to learn that might be relevant for patients about this T cell subset. [14:23] These T cells are a specific subset of the group of Th2 T cells, which are a subset of all CD4 T cells. Some CD4 T cells are important for responding to viruses and tumors. Others are important for responding to outside allergens. [15:01] In an allergy or a parasite infection, Th2 T cells are important. There is a subset of T cells that is driven by repetitive and chronic exposure to the triggering protein, antigen, or allergen. [15:47] Most antigens are proteins that trigger an immune response. An antigen that elicits an allergic response is an allergen. [16:30] A food trigger is a protein antigen that is an allergen. In IgE, food allergies, milk, and eggs are prevalent triggers early in life. For reasons not well understood, a lot of people outgrow them. In older patients, peanut and tree nut allergies are prevalent. [17:01] In EoE, milk is one of the most common dietary triggers into adulthood. Some patients with IgE allergy to milk can tolerate it if it's well cooked. Patients with EoE are less likely to be able to get away with regular and ongoing exposure to milk protein. [17:54] Milk, eggs, and nuts are common triggers in both conditions. There can also be rare food allergy triggers. That's part of the early evidence that the adaptive immune response was likely to be involved. It can be so specific for some people to rare things. [18:20] Hallmarks of something being immune-mediated are that it is reproducibly demonstrable as a trigger. It's going to be long-lived. It's going to be generally relatively small amounts. The immune system is good at detecting small exposures. [19:07] EoE is tricky because there's not that clear and easy temporal association between an offending allergen exposure for most people and their symptoms. People don't associate the symptoms with the triggers. [20:14] A history of having blood in the stools can be milk-allergen-driven and was associated with a diagnosis of EoE in those kids when they're older. [20:26] There are a lot of commonalities in the allergens but it's not always obvious clinically. [22:40] A challenge in diagnosing EoE is that providers have to be on guard against their biases. They have to give a patient good advice. In EoE there is no test to identify triggers, except rigorous introduction, elimination, reintroduction, and endoscopies. [24:18] For some of Dr, Shreffler's patients, it becomes less important to know their dietary triggers. They gravitate toward an approved form of treatment that may, if successful, allow them to have a more normal diet because of effective medication. [24:50] Dr. Shreffler thinks there are other triggers, including pollens. There is evidence of seasonality of active EoE in patients shown to have allergic sensitization to pollens. That's indirect evidence. If the body is making IgE, it's likely making other responses. [25:32] There are questions about how large the population of patients is who have EoE that may be more intrinsically than extrinsically driven because of genetic variations. [25:54] Dr. Shreffler believes that EoE in some patients is allergen-driven and in some patients EoE is food-driven. Food is a trigger for the majority of pediatric patients and a large percentage of adult patients but not necessarily the exclusive trigger. [27:04] If a patient is motivated to learn what dietary triggers may be at play, Dr. Shreffler often makes assessments outside of pollen season for allergens to which the patient has demonstrated positivity. [28:09] Looking at the epidemiology, both EoE and food allergy are atopic disorders. You see an increased prevalence of asthma, hay fever, eczema, and even allergic proctocolitis in infancy. You see an enrichment of one disorder to another. [28:29] The overlap of food allergy to EoE is stronger than you might expect. About 30 to 40% of patients with EoE will also have IgE food allergy. A higher rate will have IgE positivity, whether or not that food is a trigger of immediate symptoms. [28:48] Patients with food allergies are about four times more likely to have EoE than the general population. That's a stronger association than the risk of eczema or other atopic conditions to EoE. [30:09] There are differences between IgE food allergy and EoE. The presence of IgE gives a useful tool for identifying the food trigger in food allergy, but not in EoE. Identifying rare triggers in EoE patients is done by clinical observation. [31:46] Epinephrine and antihistamines are not useful in treating EoE. Blocking IgE with Omalizumab has not been effective in trials in treating EoE. PPIs, topical steroids, and dupilumab are helpful for many EoE patients. [32:38] Dupilumab has been evaluated a bit in food allergy in combination with OIT, and there was no statistically significant benefit from dupilumab in food allergy. [33:25] A group in Pennsylvania has been evaluating epicutaneous immunotherapy as a modality to treat EoE. It's also being evaluated for IgE food allergy. Dr. Shreffler thinks it's something to keep an eye on. [33:40] The oral route for immunotherapy can drive EoE for patients. As they become less sensitive from an immediate reactivity viewpoint, a significant percentage of patients develop GI symptoms. This has also been observed with sublingual therapy. [34:14] Iatrogenic EoE, caused by the treatment, may resolve on the cessation of the immunotherapy treatment. [36:25] Dr. Shreffler says in some cases, the shared decision is a decision where he has a strong evidence-based opinion. In some cases, there's a lot more room for a range of clinical decisions that could be equally supported by what we know right now. [36:57] We've said that EoE is a contraindication for OIT. There is a shift happening. Dr. Shreffler sits with families and has a conversation about restricting diet or trying chronic therapy and keeping an ad-lib diet. [37:38] What about doing the same thing by treating the immediate-type food allergy with chronic allergen exposure and then ameliorating the effects of EoE if it emerges, with another therapy? A hundred providers would have a diversity of responses. [38:19] When there is a history of EoE in a family, Dr. Shreffler advocates for getting a baseline scope. It becomes an important “ground zero.” [38:28] The goal is to have less invasive ways to monitor these conditions. [39:32] Chronic inflammation, which is the hallmark of EoE, is well-targeted by therapies like PPIs and steroids. Steroids don't help with IgE-related food allergies. They're not effective at blocking the IgE-driven immediate response. [41:13] Until recently, IgE food allergy has only been managed with avoidance. We have some other tools now. Xolair is not effective in EoE but is effective in two-thirds to three-quarters of patients with immediate-type food allergies for preventing anaphylaxis. [41:45] Dr. Shreffler refers to an upcoming study on the effectiveness of Xolair in treating people with food allergies. Those who were able to tolerate a minimum amount were allowed to begin consuming allergen. We'll get insight into how those patients did. [43:08] Food-induced immediate response of the esophagus (FIRE) is immediate discomfort with exposure to some allergens. Dr. Shreffler explains it. Data supports that these patients are experiencing an IgE-mediated but local response to those triggers. [44:59] If FIRE is IgE-mediated, it may be that Xolair would help suppress it in these patients. It's worth looking at Xolair for this subset of EoE patients. [45:20] Ryan invites any listeners who want to learn more about FIRE to check out episode #34 with Dr. Nirmala Gonsalvez. [45:37] In the paper, Dr. Shreffler wrote about what he hopes will be the practical usefulness of the finding, the intersection between IgE food allergy and EoE. [45:56] A subset of Th2 T cells express a protein called GPR15. It appears to be a marker for the subset of cells that are playing a role in the EoE. [46:36] Caitlin Burk's work now is looking at their activation status in active disease and post-diet elimination and remission. She is developing a data set that is leading us toward the possibility of focusing on that cell subset and techniques to adopt in clinics. [47:12] She is also working out more advanced techniques to look at the receptors. Dr. David Hill at CHOP is working on similar research. This research has the potential to lead to the development of better tests for EoE. [47:44] Holly tells Dr. Shreffler this has been such an informative episode with so many tidbits of things to help patients advocate for themselves. Holly thanks him for sharing all of that. [48:12] Dr. Shreffler is trying to see what can be utilized from their research to make non-invasive tests to identify food allergen triggers for patients so they don't have to go through so many endoscopies. He sees it as a huge unmet need. [48:31] Ryan thanks Dr. Shreffler for joining us. For our listeners who would like to learn more about eosinophilic disorders, including EoE, please visit APFED.org and check out the links in the show notes. [48:41] If you're looking to find a specialist who treats eosinophilic disorders, we encourage you to use APFED's Specialist Finder at APFED.org/specialist. [48:50] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at APFED.org/connections. [49:00] Ryan thanks Dr. Shreffler for joining us today for this interesting conversation. Holly also thanks APFED's Education Partners Bristol Myers Squibb, GSK, Sanofi, and Regeneron for supporting this episode. Mentioned in This Episode: Dr. Wayne Shreffler, MD, Ph.D., Chief of Pediatric Allergy and Immunology and Co-Director of The Food Allergy Center at Massachusetts General Hospital “Triggers for eosinophilic esophagitis (EoE): The intersection of food allergy and EoE” Dr. Caitlin Burk Dr. David A. Hill APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections Education Partners: This episode of APFED's podcast is brought to you thanks to the support of Bristol Myers Squibb, GSK, Sanofi, and Regeneron. Tweetables: “This fascinating problem of food allergy: why does the immune system do that for some people — recognize what should be nutritive and innocuous sources of energy as an immunological trigger? ” — Dr. Wayne Shreffler “A food allergy; because there is this IgE antibody, we can do skin tests. We can measure that in the blood. It's a useful marker for helping to identify which foods are the trigger.” — Dr. Wayne Shreffler “EoE is tricky because there's not that clear and easy temporal association between an offending allergen exposure for most people and their symptoms. People don't associate the symptoms with the triggers.” — Dr. Wayne Shreffler “Everything is shared decision-making. In some cases, it's a shared decision where I have a strong evidence-based opinion. In some cases, there's a lot more room for a range of clinical decisions that could be equally justified.” — Dr. Wayne Shreffler “Steroids don't help with IgE-related food allergy. They're not effective at blocking that IgE-driven immediate response.” — Dr. Wayne Shreffler “I'm trying to see what we can utilize from our research to make non-invasive tests to identify food allergen triggers for patients so they don't have to go through so many endoscopies. I think that's a huge unmet need.” — Dr. Wayne Shreffler
Send us a text“I do think it's important that we understand that not all the foods are the same, and I think anyone who's seen patients in clinics understands this.” – Dr. Edwin KimCould sublingual immunotherapy (SLIT) be the peanut allergy solution allergists have been waiting for? In this episode, Dr. Mariam Hanna welcomes Dr. Edwin Kim, Division Chief of Pediatric Allergy and Immunology at the University of North Carolina, to dive into the science, practicality, and potential of SLIT. With a reputation for safety and ease of use, SLIT is gaining traction—but as Dr. Kim emphasizes, the evidence for other foods like milk, egg, and tree nuts remains extremely limited.On this episode:What is SLIT? A low-dose therapy held under the tongue, offering bite-proof protection with minimal side effects like mouth itch, making it a low-risk option for many patients.Why choose SLIT? Why some patients prefer SLIT's simplicity, including fewer restrictions on exercise and observation, compared to oral immunotherapy.Why peanuts? SLIT shows strong results for peanuts, but research on expanding to milk, egg, and tree nuts is still in its early stages, with unique challenges for each food.Who benefits most? Younger patients who thrive on routine and those seeking protection from accidental exposures without needing to eat large quantities of allergens.What lies ahead? Optimizing dosing for different foods, improving outcomes for patients with low thresholds, and expanding access to non-peanut allergens.Whether you're curious about incorporating SLIT into clinical practice or exploring its limits, this episode delivers evidence-based insights. Tune in now to see if SLIT is the right fit for your patients!Visit the Canadian Society of Allergy and Clinical ImmunologyFind an allergist using our helpful toolFind Dr. Hanna on X, previously Twitter, @PedsAllergyDoc or CSACI @CSACI_caThe Allergist is produced for CSACI by PodCraft Productions
L'asthme, une maladie inflammatoire chronique des voies respiratoires, est couramment associée à des symptômes tels que la toux, la respiration sifflante et l'essoufflement. Cependant, des recherches récentes suggèrent que l'asthme infantile pourrait également avoir des répercussions sur les fonctions cognitives, notamment la mémoire. Impact de l'asthme sur la mémoire chez l'enfant Une étude publiée en 2023 dans la revue Pediatric Allergy and Immunology a examiné les performances cognitives de 200 enfants âgés de 6 à 12 ans, dont 100 souffrant d'asthme modéré à sévère et 100 en bonne santé. Les résultats ont révélé que les enfants asthmatiques présentaient des scores significativement inférieurs aux tests de mémoire verbale et de mémoire de travail par rapport au groupe témoin. Cette étude suggère que l'asthme peut être associé à des altérations spécifiques de la mémoire chez l'enfant. Mécanismes potentiels expliquant cette association Plusieurs hypothèses pourraient expliquer le lien entre l'asthme infantile et les troubles de la mémoire : 1. Hypoxie cérébrale : Les crises d'asthme sévères peuvent entraîner une diminution de l'oxygénation du cerveau, affectant ainsi les fonctions cognitives, y compris la mémoire. 2. Inflammation systémique : L'asthme est caractérisé par une inflammation chronique qui pourrait avoir des effets neuroinflammatoires, perturbant les processus cognitifs. 3. Effets secondaires des traitements : Certains médicaments utilisés pour gérer l'asthme, tels que les corticostéroïdes, peuvent avoir des impacts sur l'humeur et la cognition, bien que les données soient encore limitées. 4. Perturbations du sommeil : Les symptômes nocturnes de l'asthme peuvent altérer la qualité du sommeil, ce qui est essentiel pour la consolidation de la mémoire. Conséquences et recommandations Les implications de ces découvertes sont significatives. Une altération de la mémoire chez l'enfant peut entraîner des difficultés scolaires et affecter le développement social et émotionnel. Il est donc crucial que les professionnels de santé prennent en compte ces aspects lors de la prise en charge des jeunes patients asthmatiques. Des interventions telles que la gestion optimale de l'asthme pour minimiser les symptômes, l'évaluation régulière des fonctions cognitives et la mise en place de stratégies éducatives adaptées peuvent aider à atténuer ces effets. De plus, la sensibilisation des parents et des éducateurs à ces enjeux est essentielle pour offrir un soutien approprié aux enfants concernés. Conclusion Bien que l'asthme soit principalement une affection respiratoire, ses répercussions potentielles sur la mémoire et d'autres fonctions cognitives chez l'enfant ne doivent pas être négligées. Des recherches supplémentaires sont nécessaires pour approfondir la compréhension de ces liens et développer des stratégies d'intervention efficaces. En attendant, une approche holistique de la prise en charge de l'asthme infantile, intégrant la dimension cognitive, est recommandée pour assurer le bien-être global de l'enfant. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.
Food allergies are often top of mind for parents during Halloween. Dr. Christine McCusker is Director of the Division of Pediatric Allergy and Immunology at the Montreal Children's Hospital. She spoke to Andrew Carter about what parents should be looking out for when trick-or-treating.
Dr. Chong is the Chief of the Division of Pediatric Allergy and Immunology and Assistant Professor of Pediatrics in the Division of Allergy and Immunology. At the Center for Rare Disease Therapy at UPMC Children's, Dr. Chong's role often involves evaluating patients with immune disorders to determine whether they are candidates for a bone marrow transplant.
This week I sit down with Dr. Stan Gabryszewski to discuss allergies from multiple angles. Dr. Gabryszewski graduated from Princeton University with a degree in Molecular Biology before attending Columbia University for his MD as well as a PhD degree in Cellular, Molecular and Biomedical Studies. He then completed his pediatric residency and is a senior allergy immunology fellow at the Children's Hospital of Philadelphia where he now teaches and performs research in the lab of Dr. David Hall. His research is focused on better understanding the epidemiologic and immunologic features among pediatric allergic disorders, in particular the food allergies IgE-mediated food allergy and eosinophilic esophagitis. In this conversation, Stan and I sit down to discuss his recent paper in Pediatrics entitled, Patterns in the Development of Pediatric Allergy. This article is a much needed look at the true prevalence of allergy and allergic diseases in children. We discuss the statistics as well as the thoughts behind the why this is occurring. The upstream reasons are very important, hard to tease out but worthy of discussion. Please enjoy my conversation with Stan Gabryszewski, Dr. M His recent paper in pediatrics.
Host: Jennifer Caudle, DO Guest: Sayantani Sindher, MD Recently, Omalizumab was studied in patients due to the avoidance of management and guidance when it comes to treating food allergies in children and adults. According to this doctor, approximately 45 percent of patients seen in his clinic have multi-food allergies that are not being met with current treatment options. So to explain his research, Dr. Jennifer Caudle is joined by Dr. Sayantani Sinder, Clinical Associate Professor of Medicine and Pediatric Allergy and Clinical Immunology Physician at Stanford Healthcare and Stanford Medicine Children's Health.
Are you ready to debunk common myths about allergies and dive into the evolving world of allergy and immunology? In this episode of the "Becoming Immune Confident" podcast, host Dr. Kara Wada hosts her mentor and colleague, Dr. David Stukus. Dr. Stukus discusses his career journey in allergy and immunology, highlighting the importance of countering health misinformation. He provides an in-depth insight into allergies, the different reactions they can cause, and how they differ from intolerances. Dr. Stukus emphasizes the role of patient history in diagnosis. He also provides an overview of the current and emerging treatments for food allergies, Whether you're a medical professional, a patient navigating the complex world of allergies, or just curious about the latest in allergy research and misinformation busting, this episode has something for everyone! Join Dr. Kara and Dr. Stukus as they unravel the intricacies of allergies and the innovative ways medical professionals are using social media to educate and lead. EPISODE IN A GLANCE-Dr. David Stukus' Journey into Allergy and Immunology-Social Media's Role in Medicine-Discovering the Field of Allergy-Understanding Food Allergy-The Complexity of Food Allergy-Future of Food Allergy Treatment-Communicating Medical Information on Social Media-Connect with Dr. David Stukus ABOUT DR DAVID STUKUSDavid Stukus, MD, Professor of Clinical Pediatrics and Director of the Food Allergy Treatment Center at Nationwide Children's Hospital, is renowned for his expertise in allergy and immunology. He founded the Complex Asthma Clinic and is actively involved in clinical care, research, and patient advocacy. An influential speaker and leader in professional organizations like AAAAI and ACAAI, Dr. Stukus also serves as the Social Media Medical Editor for AAAAI, where he hosts the "Conversations From the World of Allergy" podcast. Recognized as a Top Doctor in Pediatric Allergy since 2015, he is committed to evidence-based medicine, educating a wide audience through social media as @AllergyKidsDoc, and has authored a textbook on social media in medicine. Dr. Stukus, a graduate of the University of Pittsburgh School of Medicine, completed his residency and fellowship at Nationwide Children's Hospital and the Cleveland Clinic. He lives in central Ohio with his wife, Kristin, a pediatric emergency physician, and their two children. CONNECT WITH DR DAVID STUKUSInstagram → https://www.instagram.com/allergykidsdoc Twitter → https://twitter.com/AllergyKidsDoc LinkedIn → https://www.linkedin.com/in/david-stukus-04126aa8/ ABOUT DR KARA WADAQuadruple board-certified pediatric and adult allergy immunology & lifestyle medicine physician, Sjogren's patient and life coach shares her recipe for success combining anti-inflammatory lifestyle, trusting therapeutic relationships, modern medicine & our minds to harness our body's ability to heal. CONNECT WITH DR WADAWebsite → https://www.drkarawada.com/ LinkedIn → https://www.linkedin.com/in/crunchyallergist/ Instagram → https://www.instagram.com/crunchyallergist/ Facebook → https://www.facebook.com/CrunchyAllergist Twitter → https://twitter.com/CrunchyAllergy TikTok → https://www.tiktok.com/@crunchyallergist SUBSCRIBE TO NEWSLETTER → https://www.drkarawada.com/newsletter Get Dr. Kara's weekly dose of a naturally-minded and scientifically-grounded approach to immune system health. JOIN THE BECOMING IMMUNE CONFIDENT JUMPSTART! If you are looking for support and realize that 2024 is 2024 the year that you gain a deep understanding of your body, learn to trust your ability to navigate the uncertainties that come along with living with chronic inflammation and build a lifestyle that supports and nourishes your immune system...APPLY HERE→ https://www.immuneconfident.com Register for The Demystifying Inflammation Summit 2023 EncoreA free 3-day event to empower families with allergies, asthma & autoimmune conditions. Learn more and grab your free ticket → https://bit.ly/inflammation-summit-encore
In this case study Prof John Warner interviews a mother whose 8-year-old child suffers from persistent allergies. Could it be dust mites? Listen in on this consultation to see how allergies are diagnosed.Prof. John Warner is a Professor of Paediatrics at Imperial College London and the University of Cape Town. His research has focused on the early life origins of asthma and related allergic and respiratory disorders. He has published over 400 papers in scientific journals on these topics. He was Editor-in-Chief of the journal Pediatric Allergy and Immunology from 1997-2010 and chairman of the paediatric section of the British Society for Allergy and Clinical Immunology for 5 years until 2010. He is also a member of the Speciality and Training Committee of the World Allergy Organisation and a past Trustee of the charity known as The Anaphylaxis Campaign. He was a member of the Advisory Committee for Novel Foods and Processes of the Food Standards Agency for 12 years until 2012 and was recognised for his work in food allergy research by the award of an OBE in 2013. Get bonus content on Patreon Hosted on Acast. See acast.com/privacy for more information.
Join host Mike Finch, Dr Jill Warner and Emeritus Professor John Warner to break down the effect allergies have on sleep quality. The panel discuss the various allergens affecting sleep - from dust mites in your bed to cat dander - and how best to deal with them. Dr Jill Warner has a BSc in Immunology and Physiology and a PhD in Allergy from the University of London. She is currently an Honorary Professor in Paediatrics at The University of Cape Town and her research interests are in the foetal origins of allergic disease and environmental allergen avoidance. Dr Jill Warner has published over 100 peer-reviewed papers and journal articles in the field of allergy. Prof. John Warner is a Professor of Paediatrics at Imperial College London and the University of Cape Town. His research has focused on the early life origins of asthma and related allergic and respiratory disorders. He has published over 400 papers in scientific journals on these topics. He was Editor-in-Chief of the journal Pediatric Allergy and Immunology from 1997-2010 and chairman of the paediatric section of the British Society for Allergy and Clinical Immunology for 5 years until 2010. He is also a member of the Speciality and Training Committee of the World Allergy Organisation and a past Trustee of the charity known as The Anaphylaxis Campaign. He was a member of the Advisory Committee for Novel Foods and Processes of the Food Standards Agency for 12 years until 2012 and was recognised for his work in food allergy research by the award of an OBE in 2013. Get bonus content on Patreon Hosted on Acast. See acast.com/privacy for more information.
You ask, they answer. From the National Eczema Association, this is Eczema Answered, where wold-class experts answer your question about eczema. Here's what you asked: "Why is there no cure for eczema?" Donald Y M Leung, MD, PhD, is a Distinguished Professor of Pediatrics, allergist and immunologist at National Jewish Health. Dr. Leung serves as Division Head of Pediatric Allergy and Clinical Immunology. Do you have a question about eczema that you want answered? Email us at podcast@nationaleczema.org National Eczema Association The National Eczema Association is the driving force for an eczema community fueled by knowledge, strengthened through collective action and propelled by the promise for a better future.
With many new options for managing food allergies, including treatments, shared decision-making is at the forefront of best practices for working with your doctor. Learn about shared decision-making and how your family can benefit from this process. Leading this essential discussion is Douglas P. Mack, MSc, MD, FRCPC, FCSACI Board of Directors - Canadian Society of Allergy and Clinical Immunology, Pediatric Allergy, Asthma and Immunology, and Assistant Clinical Professor, McMaster University.To keep you in the know, below are helpful resources:FAACT's WebsiteFAACT's Navigating the Food Allergy Treatment Decision ProcessFAACT's Navigating the Food Allergy Treatment Decision Process PosterYou can find the FAACT Roundtable Podcast on Pandora, Apple Podcast, Spotify, Google Podcast, Stitcher, iHeart Radio, Podcast Chaser, Deezer, and Listen Notes.Follow us on Facebook, Twitter, Instagram, LinkedIn, TikTok, & Pinterest.Sponsored by: The National Peanut Board*Please note that today's guests were not sponsored by the National Peanut Board or compensated in any way by the sponsor to participate in this specific podcast.Thanks for listening! FAACT invites you to discover more exciting food allergy resources at FoodAllergyAwareness.org!
American children are ten times more likely to experience food allergies than Israeli children. So what's going on? Why aren't they experiencing such dire allergies at the same rate as us? The answer lies in something so simple: Bambas, an iconic peanut-flavored snack considered a staple of Israeli childhood. Instead of provoking an allergy, early exposure to peanuts seems to help build tolerance. In this episode, we look at food allergies in general, what causes children's food allergies, and how we can prevent them. Dr. Gideon Lack, Head of The Department of Pediatric Allergy, Kings College, London & Lead Author of the LEAP Study Sherry Coleman Collins aka PeanutRD, registered dietitian, nutritionist, food allergy specialist Looking for more in-depth learning experiences on Anatomy & Physiology or other topics? Sign up for Pearson+ today to explore content from experts like Joan Salge Blake. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Join Dr. Danielle Belardo and her expert of the week, pediatric allergist and immunologist Dr. David Stukus, for a myth-busting episode about food allergies, intolerances, and "sensitivities." Danielle and David crack down on food "sensitivity" scams and unnecessary, unvalidated tests that people all over social media are falling victim to. Even allergies have a dark side, so tune in to learn what is fact and what is, simply, fiction. Danielle and David discuss: The basic terminology and meaning of food allergies, sensitivities, and intolerances The difference between IgG and IgE and why IgG testing isn't validated or accurate Low histamine diets and the pseudoscience claims these diets make How to use a trial, elimination, and reintroduction diet to discover food intolerances Why an oral food challenge is the gold standard for allergy testing Ways to find a provider to get an accurate allergy diagnosis Red flags for spotting allergy misinformation on social media David Stukus, MD, is a Professor of Clinical Pediatrics in the Division of Allergy and Immunology. Prior to becoming the director of the Food Allergy Treatment Center, Dr. Stukus started the Complex Asthma Clinic at Nationwide Children's Hospital in 2011, which treats children with severe or difficult-to-treat asthma. He holds multiple leadership positions in the American Academy of Allergy, Asthma, and Immunology (AAAAI) and the American College of Allergy, Asthma, and Immunology and is one of twelve allergists invited as a member of the Joint Task Force for Practice Parameters. He is the Social Media Medical Editor for the AAAAI, where he produces and hosts their podcast "Conversations From the World of Allergy." He has been named a Top Doctor in Pediatric Allergy every year since 2015. Thank you so much for taking the time to contribute to a generation that values fact over fiction! Be sure to rate, review, and follow on your favorite podcast app and let us know which not-so-wellness trend you'd like to hear debunked. Follow your host on Instagram @daniellebelardomd and the podcast @wellnessfactvsfiction. All studies discussed can be found @wellnessfvfjournalclub. Follow Dr. Dave @allergykidsdoc. Thank you to our sponsors for making this episode possible. Check out these deals just for you: COZY EARTH - Go to cozyearth.com and enter WELLNESS at checkout to SAVE thirty-five Percent. ZOCDOC - Go to zocdoc.com/wellness and download the Zocdoc app for FREE. Then start your search for a top-rated doctor today.
There is not a pediatric clinician among us who doesn't have a patient with allergies, including food allergies, environmental allergies and/or seasonal allergies. On this episode, we talk with Dr Nicole Chase, pediatric allergist and immunologist, about all things allergy including: current recommendations for food introduction, oral food challenges, pitfalls in “allergy testing” in primary care and what's new and on the horizon for treatment of allergies with immunotherapy.
Dr. Scott H. Sicherer is the Director of the Elliot and Roslyn Jaffe Food Allergy Institute and the Elliot and Roslyn Jaffe Professor of Pediatric Allergy and Immunology. He is Chief of the Division of Allergy and Immunology in the Department of Pediatrics and Medical Director of the Clinical Research Unit, a component of Conduits-the Institutes for Translational Sciences at Icahn School of Medicine at Mount Sinai. He also authored Food Allergies: A Complete Guide For Eating When Your Life Depends on It. Dr. Sicherer shares with our listeners his incredible wealth of knowledge. Topics covered in this episode include what a reaction may look like, treatment expectations if an ER visit is necessary, oral food challenges (medically supervised feeding), the diagnostic process, causes of food allergies, and much more.
Your Personal Child Specialist ! (rated World's top 5 Child health Podcast, Heard In 80 Countries!)
Mixed bag of questions about allergy & asthma including skin, eye nose and chest allergies How to differentiate between allergies and infections? What are common presentations of allergy in children? When should we see an allergy specialist? Is snoring an indicator of allergy? Can constipation be related to any adverse food reaction? Nowadays children often complain of recurrent abdominal pains? How to deal with that? It's a common saying “allergy means Allah ki marzi “ . Is it true that we can't do anything about it ? Can we cure asthma in children? Our chemical exposure through the environment is increasing … may it be through food habits (preservatives), water, air …. What can we do to protect our children from getting affected by it ? Can vitamins help in our protection from allergies? Can probiotics help protect against allergies? What natural foods can help improve immunity? https://healthier.stanfordchildrens.org/en/how-parents-can-help-prevent-food-allergies-in-kids/ https://www.aaaai.org/tools-for-the-public/conditions-library/allergies/prevention-of-allergies-and-asthma-in-children https://kidshealth.org/en/parents/allergy.html --- Send in a voice message: https://anchor.fm/gaurav-gupta6/message
Your Personal Child Specialist ! (rated World's top 5 Child health Podcast, Heard In 80 Countries!)
The incidence of allergies and asthma in kids in rising in India and across the world. Here I connect with Dr Swati to talk about how we can reduce this, starting from pregnancy, to the new born baby, the infant and then the older child. We talk about probiotics, diet, the correct way to wean, and how to prevent food allergies and asthma and aero-allergy. What to AVOID keeping in the child's room and the importance of fluids in the diet of children. For this and much more, keep listening --- Send in a voice message: https://anchor.fm/gaurav-gupta6/message
Dr. Walter, Division Chief of the Department of Pediatric Allergy and Immunology at Johns Hopkins All Children’s Hospital, presents this basic review of Immunology. Dr. Walter begins by reviewing the basic classification of general immunodeficiency syndromes, and then covers the initial work-up for patients who are suspected as having an immune system deficiency. She then discusses signs and syndromes in specific patients that could suggest a primary immunodeficiency. Next, she discusses antibody deficiency syndromes and autoantibodies, She closes by discussing a specific immunodeficiency case with relevant details highlighted within the presentation.
While more than 10% of patients in the U.S. have a penicillin allergy noted in their medical record, many of these patients are not allergic and have either outgrown their allergy or actually experienced viral rash or nonimmunological adverse reactions. In this episode, we will talk through recently published studies that inform efforts to delabel patients who are incorrectly labeled as penicillin allergic. Our guest for today's episode is Dr. Kirstin Carel. Dr. Carel is part of our Allergy and Immunology Team at Children's Hospital Colorado and is Associate Professor of Pediatric Allergy and Immunology at the University of Colorado School of Medicine. Do you have thoughts about today's episode or suggestions for a future topic? Write to us, chartingpediatrics@childrenscolorado.org
This is Part 2 of a two-part series exploring when it is time to consume allergens from the perspectives of board-certified allergists. Listen and learn today with FAACT.We conclude this information-packed series with two allergists: Brian Schroer, MD, Division Director of Allergy and Immunology at Akron Children's Hospital and Associate Professor Pediatrics Northeast Ohio College of Medicine and Douglas P. Mack, MSc, MD, FRCPC, FCSACI Board of Directors - Canadian Society of Allergy and Clinical Immunology, Pediatric Allergy, Asthma and Immunology, and Assistant Clinical Professor, McMaster University.To keep you in the know, here are a few links to topics mentioned in the podcast:Eating Baked, Roasted or Raw - Food Allergen Must-Knows (Part 1 - the Registered Dietician Perspective) - FAACT Roundtable Podcast Ep. 62"Practical Challenges and Considerations for Early Introduction of Potential Food Allergens for Prevention of Food Allergy" Research Paper You can find FAACT's Roundtable Podcast on Pandora, Apple Podcast, Spotify, Google Podcast, Stitcher, iHeart Radio, Podcast Chaser, Deezer, and Listen Notes.Visit us at www.FoodAllergyAwareness.org and follow us on Facebook, Twitter, Instagram, LinkedIn, Pinterest, and YouTube. Contact us directly via Email.Sponsored by: DBV Technologies*Please note that today's guests were not sponsored by DBV Technologies or compensated in any way by the sponsor to participate in this specific podcast.
In this episode, Dr. David Stukus joins me to discuss asthma and allergies for athletic and non-athletic populations. We talk about some of the common misconceptions surrounding treatment for these conditions, and how changes in weather can have profound effects on individuals dealing with asthma and environmental allergies. Dr. Stukus also gets into some of the research regarding the Covid19 vaccines, discusses how they differ, and how they work. I learned a ton from this conversation! David Stukus, MD, is an associate professor of Pediatrics in the Division of Allergy and Immunology. Prior to becoming the director of the Food Allergy Treatment Center, Dr. Stukus started the Complex Asthma Clinic at Nationwide Children's Hospital in 2011, which treats children with severe or difficult-to-treat asthma. In addition to providing clinical care for children with all types of allergic conditions, Dr. Stukus participates in clinical research, quality improvement, patient advocacy, and medical education. An internationally recognized keynote speaker, Dr. Stukus has received named lectureships and awards from various national and international organizations. Dr. Stukus holds multiple leadership positions in the American Academy of Allergy, Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma, and Immunology and is one of twelve allergists invited as a member of the Joint Task Force for Practice Parameters. In 2018, Dr. Stukus was invited to become the first Social Media Medical Editor for the AAAAI, where he produces and hosts their podcast "Conversations From the World of Allergy". He has been named a Top Doctor in Pediatric Allergy every year since 2015. Dr. Stukus obtained his medical degree at the University of Pittsburgh School of Medicine. He completed his residency at Nationwide Children's Hospital and his fellowship at the Cleveland Clinic. He is Board Certified in Allergy/Immunology and Pediatrics. Follow Dr. Stukus on Instagram and Twitter: @AllergyKidsDoc
Dr. Patricia Whitley-Williams, President of the National Foundation for Infectious Diseases (NFID) discusses the persistent gaps and racial disparities in vaccination coverage. She talks about the new NFID survey findings and explains the urgent need to encourage individuals to get vaccinated against both flu and COVID-19. Patricia N. Whitley-Williams, MD, is president of the National Foundation for Infectious Diseases (NFID) and is professor of pediatrics; chief of the Division of Pediatric Allergy, Immunology, and Infectious Diseases; and associate dean of inclusion and diversity at Rutgers Robert Wood Johnson Medical School. A native of Boston, she received a bachelor of science degree in biology from Simmons College in Boston and a medical degree from Johns Hopkins University School of Medicine. She completed her pediatric residency at Children’s Hospital Medical Center in Cincinnati and fellowship training in pediatric infectious diseases at Boston City Hospital/Boston University School of Medicine.She served on the faculty of Boston University School of Medicine as an assistant professor of pediatrics before joining the faculty of the Morehouse School of Medicine as an assistant professor of pediatrics and associate dean for clinical students. She was associate professor and interim chair of the Department of Pediatrics at Morehouse School of Medicine in Atlanta, GA from 1990 to 1993. In September of 1993, Dr. Whitley-Williams joined the faculty of the University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School as associate professor of clinical pediatrics. She is board certified in pediatrics and pediatric infectious diseases and is a Fellow of the American Academy of Pediatrics.She is a member of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, the American Academy of Pediatrics, and the National Medical Association (NMA). She serves on the NMA COVID-19 Task Force and as the NMA liaison to the Advisory Committee on Immunization Practices at the Centers for Disease Control and Prevention. She is the immediate past chair of the US Medical Licensure Examination Management Committee as well as a member of the National Board of Medical Examiners Governance Review Task Force and Nominating Committee. She participates in community outreach projects as an active member of the Central Jersey Alumnae Chapter of Delta Sigma Theta Sorority, Inc. Her research interests include HIV/AIDS in women and children as well as adult, childhood and adolescent immunization.
In this episode, the Fit Black Queens interview Dr. Patricia N. Whitley-Williams, President of the National Foundation for Infectious Diseases (NFID) and Chief of the Division of Pediatric Allergy, Immunology, and Infectious Diseases and Associate Dean of Inclusion and Diversity at Rutgers Robert Wood Johnson Medical School. Dr. Whitley-Williams shares information about the COVID-19 vaccine, including an explanation of how the vaccine works, and why it's important to get both the flu and COVID-19 vaccine this year. Read NFID's latest report, National Survey: Black Adult Perspectives on COVID-19 and Flu Vaccines. --- Send in a voice message: https://anchor.fm/fitblackqueens/message Support this podcast: https://anchor.fm/fitblackqueens/support
Today's guests: Simon Somogyi, Professor / Arrell Chair in the Business of Food - University of Guelph. Michael von Massow, Professor / Food Economist - University of Guelph Dr. Edmond Chan, Head of the Division of Pediatric Allergy and Immunology - UBC Faculty of Medicine / Clinical investigator at BC Children's Hospital Research Institute See omnystudio.com/listener for privacy information.
Dr. Chong is the Chief of the Division of Pediatric Allergy and Immunology and Assistant Professor of Pediatrics in the Division of Allergy and Immunology. At the Center for Rare Disease Therapy at UPMC Children’s, Dr. Chong’s role often involves evaluating patients with immune disorders to determine whether they are candidates for a bone marrow transplant.
Wanna order an online home food sensitivity/allergy/intolerance testing kit to see if you have a case of the glutens? Here's why no self-respecting doctor would recommend that garbage. Against Medical Advice (AMA) #39 Links, references, and audio podcast at http://zdoggmd.com/home-food-sensitivity-testing Thanks to David Stukus, MD, Associate Professor of Pediatrics and Associate Director, Pediatric Allergy & Immunology Fellowship Program at Nationwide Children's Hospital and The Ohio State University College of Medicine for helping to educate me on these kits. Check him out: http://twitter.com/allergykidsdoc http://instagram.com/allergykidsdoc Join our Supporter Tribe on FB or Patreon to get CME credits on select episodes! http://facebook.com/becomesupporter/zdoggmd http://patreon.com/zdoggmd Send Us email: zubin@turntablehealth.com Send Us Hate Mail: 1025 Alameda De Las Pulgas #218 Belmont, CA 94002 And don't forget to Subscribe, Comment, and CLICK THE BELL on YouTube to turn on notifications!
This episode features Dr. Robert Wood discussing the results of a trial of oral immunotherapy with a manufactured peanut protein product for peanut desensitization, and its potential role in clinical practice. Dr. Nancy Sokol hosts. Dr. Wood is Professor of Pediatrics and Director of Pediatric Allergy and Immunology at the Johns Hopkins University School of Medicine and Professor of International Health at the Johns Hopkins Bloomberg School of Public Health. He is Editor-in-Chief of the Allergy and Immunology specialty at UpToDate. Reference: Bird JA, Spergel JM, Jones SM, et al. Efficacy and Safety of AR101 in Oral Immunotherapy for Peanut Allergy: Results of ARC001, a Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial. J Allergy Clin Immunol Pract 2018; 6:476. Contributor Disclosure: Grant/Research/Clinical Trial Support: DBV Technologies; Aimmune; Astellas; HAL-Allergy [Food allergy].
Darren digs into Warren Buffett’s challenge where he bet $1 million that a portfolio of hedge funds couldn’t beat the S&P 500 Index fund over a ten year period. So...did it? Cristina and Pat bring you part 2 of a great chat with Pediatric Allergy and Asthma Specialist Dr. Dave Stukus who schools us on the flu shot and answers more of your questions.
Come for the Science, stay for the FUN! On this week’s show, Adam looks at the leading causes of diabetes after a listener calls Darren out on his joke linking sugar to the disease. Cristina and Pat bring you part 1 of a great chat with Pediatric Allergy and Asthma Specialist Dr. Dave Stukus who answers listener’s burning questions. Finally, Cristina and Pat hang with Dr. Ken Milne, host of Skeptic’s Guide to Emergency Medicine, and OB-GYN and master GOOP Debunker, Dr. Jen Gunter of Wielding The Lasso Of Truth.
EP 12.5 Pediatric Allergy Diagnosis & Treatment by Dr. Barbara Taylor Cox
EP 12.4 Pediatric Allergy: Pet, Drug & Insect Allergies by Dr. Barbara Taylor Cox
EP 12.3 Pediatric Allergy: Food Allergy by Dr. Barbara Taylor Cox
EP 12.2 Pediatric Allergy: Allergic Rhinitis by Dr. Barbara Taylor Cox
EP 12.1 Pediatric Allergy: Immune Mechanism by Dr. Barbara Taylor Cox
Dr. Brian Schroer of Cleveland Clinic Children’s Hospital, Center for Pediatric Allergy, will answer parent questions on a variety of food allergy topics including causes of food allergies, how to discuss allergies with your child's teacher and when to use an epi pen vs an Antihistamine. With food allergies affecting 1 in 13 children, or two in every classroom, Dr. Schroer will also talk about advocating for your child at school.
Join MitoAction to discuss Immunodeficiency Disorders and Mitochondrial Disease with Dr. Susan Pacheco from Memorial Hermann Texas Medical Center Department of Pediatric Allergy and Immunology