Podcasts about inflammatory disease

Description: Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Dr. Wayne Shreffler, Chief of Pediatric Allergy and Immunology and Co-Director of The Food Allergy Center at Massachusetts General Hospital. Dr. Shreffler is also an investigator at The Center for Immunology and Inflammatory Disease and The Food Allergy Science Initiative. His research is focused on understanding how adaptive immunity to dietary antigens is both naturally regulated and modulated by therapy in the context of food allergy. This interview covers the results of a research paper on The Intersection of Food Allergy and Eosinophilic Esophagitis, co-authored by Dr. Shreffler. Disclaimer: The information provided in this podcast is designed to support, not replace the relationship that exists between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own.   Key Takeaways: [:50] Co-host Ryan Piansky introduces the episode, brought to you thanks to the support of Education Partners Bristol Myers Squibb, GSK, Sanofi, and Regeneron. Ryan introduces co-host, Holly Knotowicz.   [1:15] Holly introduces today's topic, the intersection of food allergy and eosinophilic esophagitis.   [1:26] Holly introduces today's guest, Dr. Wayne Shreffler, Chief of Pediatric Allergy and Immunology and Co-Director of The Food Allergy Center at Massachusetts General Hospital and an investigator at The Center for Immunology and Inflammatory Disease and The Food Allergy Science Initiative.   [1:43] Dr. Shreffler's research is focused on understanding how adaptive immunity to dietary antigens is both naturally regulated and modulated by therapy in the context of food allergy.   [1:54] Holly welcomes Dr. Shreffler to Real Talk. When Holly moved to Maine, she sent her patients to Dr. Shreffler at Mass General.   [2:25] Dr. Shreffler trained in New York on a Ph.D. track. He was interested in parasitic diseases and the Th2 immune response. Jane Curtis, a program director at Albert Einstein College of Medicine, encouraged him to consider MD/PhD programs. He did.   [3:31] Jane Curtis connected him to Hugh Sampson, who was working with others to help understand the clinical prevalence of food allergy and allergens.   [3:51] As a pediatric resident, Dr. Shreffler had seen the burden of allergic disease, caring for kids in the Bronx with asthma. His interest in Th2 immunity, the clear and compelling unmet clinical need, and the problem of food allergy guided his career.   [4:31] Dr. Shreffler's wife has food allergies and they were concerned for their children. Fortunately, neither of them developed food allergies.   [5:21] Dr. Shreffler thinks the food allergy field has a lot of people who gravitate toward it for personal reasons.   [5:53] Food allergy is an adverse response to food that is immune-mediated. There is still uncertainty about this but Dr. Shreffler believes that a large percentage of patients with EoE have some triggers that are food antigens.   [6:27] The broad definition of food allergy would include things like food protein-induced enterocolitis syndrome (FPIES).   [6:47] The way we use the term food allergy in the clinic, there are two forms: IgE-mediated allergies and non-IgE-mediated allergies, including EoE.   [7:40] Some patients have food-triggered eczema, some have FPIES.   [8:04] In 2024, Dr. Shreffler and Dr. Caitlin Burk released a paper that looked at the triggers of EoE, particularly the intersection of IgE-mediated food allergy and EoE.   [8:41] Dr. Caitlin Burk joined the group as they were publishing papers on IG food allergy and EoE. It was a moment where things unexpectedly came together.   [9:17] Adaptive immunity to food proteins comes from antibodies that cause milk allergy, egg allergy, peanut allergy, or multiple allergies. The IgE has specificity.   [9:40] T cells also are specific to proteins. They express a host of receptors that recognize almost anything the immune system might encounter. They have a long memory like B-cells.   [10:09] The overlap in these two threads of research was regarding a population of T cells that are important for mediating chronic inflammation at epithelial sites, including the gut.   [10:36] These T cells have been described in the airways in asthma, in the skin in eczema, and the GI tract. Researchers years ago had also described them as being associated with IgE food allergy. People with IgE food allergies avoid allergens.   [11:13] T cells, being associated with chronic allergic inflammation, now being associated with food allergies which are not having chronic exposures to the allergen, was interesting and surprising.   [11:30] Dr. Shreffler and his group found the T cell subset in patients who don't do well with Oral Immunotherapy (OIT) and patients who have EoE with immediate symptoms.   [12:01] Dr. Shreffler notes differences. There are immediate symptoms of IgE food allergy. There is a subset of patients with EoE who have immediate symptoms that are not fully understood. Maybe IgE plays a role there.   [12:28] There are different mechanisms for how symptoms are caused and so different ways of making a diagnosis. A food allergy with an IgE antibody can be measured through skin tests and blood tests. This can help identify which foods are the trigger.   [12:57] This common T cell subset that we see in EoE and food allergy, helps to explain why IgE alone is not always a very specific marker for identifying people who will have immediate reactions when they're exposed to the food.   [13:17] For patients who react at low levels, it's not just that they have more or better IgE but they also have an expansion of these T cells that are common between EoE and other chronic forms of allergy and IgE food allergy.   [13:41] There's a lot to learn that might be relevant for patients about this T cell subset.   [14:23] These T cells are a specific subset of the group of Th2 T cells, which are a subset of all CD4 T cells. Some CD4 T cells are important for responding to viruses and tumors. Others are important for responding to outside allergens.   [15:01] In an allergy or a parasite infection, Th2 T cells are important. There is a subset of T cells that is driven by repetitive and chronic exposure to the triggering protein, antigen, or allergen.   [15:47] Most antigens are proteins that trigger an immune response. An antigen that elicits an allergic response is an allergen. [16:30] A food trigger is a protein antigen that is an allergen. In IgE, food allergies, milk, and eggs are prevalent triggers early in life. For reasons not well understood, a lot of people outgrow them. In older patients, peanut and tree nut allergies are prevalent.   [17:01] In EoE, milk is one of the most common dietary triggers into adulthood. Some patients with IgE allergy to milk can tolerate it if it's well cooked. Patients with EoE are less likely to be able to get away with regular and ongoing exposure to milk protein.   [17:54] Milk, eggs, and nuts are common triggers in both conditions. There can also be rare food allergy triggers. That's part of the early evidence that the adaptive immune response was likely to be involved. It can be so specific for some people to rare things.   [18:20] Hallmarks of something being immune-mediated are that it is reproducibly demonstrable as a trigger. It's going to be long-lived. It's going to be generally relatively small amounts. The immune system is good at detecting small exposures.   [19:07] EoE is tricky because there's not that clear and easy temporal association between an offending allergen exposure for most people and their symptoms. People don't associate the symptoms with the triggers.   [20:14] A history of having blood in the stools can be milk-allergen-driven and was associated with a diagnosis of EoE in those kids when they're older.   [20:26] There are a lot of commonalities in the allergens but it's not always obvious clinically.   [22:40] A challenge in diagnosing EoE is that providers have to be on guard against their biases. They have to give a patient good advice. In EoE there is no test to identify triggers, except rigorous introduction, elimination, reintroduction, and endoscopies.   [24:18] For some of Dr, Shreffler's patients, it becomes less important to know their dietary triggers. They gravitate toward an approved form of treatment that may, if successful, allow them to have a more normal diet because of effective medication.   [24:50] Dr. Shreffler thinks there are other triggers, including pollens. There is evidence of seasonality of active EoE in patients shown to have allergic sensitization to pollens. That's indirect evidence. If the body is making IgE, it's likely making other responses.   [25:32] There are questions about how large the population of patients is who have EoE that may be more intrinsically than extrinsically driven because of genetic variations.   [25:54] Dr. Shreffler believes that EoE in some patients is allergen-driven and in some patients EoE is food-driven. Food is a trigger for the majority of pediatric patients and a large percentage of adult patients but not necessarily the exclusive trigger.   [27:04] If a patient is motivated to learn what dietary triggers may be at play, Dr. Shreffler often makes assessments outside of pollen season for allergens to which the patient has demonstrated positivity.   [28:09] Looking at the epidemiology, both EoE and food allergy are atopic disorders. You see an increased prevalence of asthma, hay fever, eczema, and even allergic proctocolitis in infancy. You see an enrichment of one disorder to another.   [28:29] The overlap of food allergy to EoE is stronger than you might expect. About 30 to 40% of patients with EoE will also have IgE food allergy. A higher rate will have IgE positivity, whether or not that food is a trigger of immediate symptoms.   [28:48] Patients with food allergies are about four times more likely to have EoE than the general population. That's a stronger association than the risk of eczema or other atopic conditions to EoE.   [30:09] There are differences between IgE food allergy and EoE. The presence of IgE gives a useful tool for identifying the food trigger in food allergy, but not in EoE. Identifying rare triggers in EoE patients is done by clinical observation.   [31:46] Epinephrine and antihistamines are not useful in treating EoE. Blocking IgE with Omalizumab has not been effective in trials in treating EoE. PPIs, topical steroids, and dupilumab are helpful for many EoE patients.   [32:38] Dupilumab has been evaluated a bit in food allergy in combination with OIT, and there was no statistically significant benefit from dupilumab in food allergy.   [33:25] A group in Pennsylvania has been evaluating epicutaneous immunotherapy as a modality to treat EoE. It's also being evaluated for IgE food allergy. Dr. Shreffler thinks it's something to keep an eye on.   [33:40] The oral route for immunotherapy can drive EoE for patients. As they become less sensitive from an immediate reactivity viewpoint, a significant percentage of patients develop GI symptoms. This has also been observed with sublingual therapy.   [34:14] Iatrogenic EoE, caused by the treatment, may resolve on the cessation of the immunotherapy treatment.   [36:25] Dr. Shreffler says in some cases, the shared decision is a decision where he has a strong evidence-based opinion. In some cases, there's a lot more room for a range of clinical decisions that could be equally supported by what we know right now.   [36:57] We've said that EoE is a contraindication for OIT. There is a shift happening. Dr. Shreffler sits with families and has a conversation about restricting diet or trying chronic therapy and keeping an ad-lib diet.   [37:38] What about doing the same thing by treating the immediate-type food allergy with chronic allergen exposure and then ameliorating the effects of EoE if it emerges, with another therapy? A hundred providers would have a diversity of responses.   [38:19] When there is a history of EoE in a family, Dr. Shreffler advocates for getting a baseline scope. It becomes an important “ground zero.”   [38:28] The goal is to have less invasive ways to monitor these conditions.   [39:32] Chronic inflammation, which is the hallmark of EoE, is well-targeted by therapies like PPIs and steroids. Steroids don't help with IgE-related food allergies. They're not effective at blocking the IgE-driven immediate response.   [41:13] Until recently, IgE food allergy has only been managed with avoidance. We have some other tools now. Xolair is not effective in EoE but is effective in two-thirds to three-quarters of patients with immediate-type food allergies for preventing anaphylaxis.   [41:45] Dr. Shreffler refers to an upcoming study on the effectiveness of Xolair in treating people with food allergies. Those who were able to tolerate a minimum amount were allowed to begin consuming allergen. We'll get insight into how those patients did.   [43:08] Food-induced immediate response of the esophagus (FIRE) is immediate discomfort with exposure to some allergens. Dr. Shreffler explains it. Data supports that these patients are experiencing an IgE-mediated but local response to those triggers.   [44:59] If FIRE is IgE-mediated, it may be that Xolair would help suppress it in these patients. It's worth looking at Xolair for this subset of EoE patients.   [45:20] Ryan invites any listeners who want to learn more about FIRE to check out episode #34 with Dr. Nirmala Gonsalvez.   [45:37] In the paper, Dr. Shreffler wrote about what he hopes will be the practical usefulness of the finding, the intersection between IgE food allergy and EoE.   [45:56] A subset of Th2 T cells express a protein called GPR15. It appears to be a marker for the subset of cells that are playing a role in the EoE.   [46:36] Caitlin Burk's work now is looking at their activation status in active disease and post-diet elimination and remission. She is developing a data set that is leading us toward the possibility of focusing on that cell subset and techniques to adopt in clinics.   [47:12] She is also working out more advanced techniques to look at the receptors. Dr. David Hill at CHOP is working on similar research. This research has the potential to lead to the development of better tests for EoE.   [47:44] Holly tells Dr. Shreffler this has been such an informative episode with so many tidbits of things to help patients advocate for themselves. Holly thanks him for sharing all of that.   [48:12] Dr. Shreffler is trying to see what can be utilized from their research to make non-invasive tests to identify food allergen triggers for patients so they don't have to go through so many endoscopies. He sees it as a huge unmet need.   [48:31] Ryan thanks Dr. Shreffler for joining us. For our listeners who would like to learn more about eosinophilic disorders, including EoE, please visit APFED.org and check out the links in the show notes.   [48:41] If you're looking to find a specialist who treats eosinophilic disorders, we encourage you to use APFED's Specialist Finder at APFED.org/specialist.   [48:50] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at APFED.org/connections.   [49:00] Ryan thanks Dr. Shreffler for joining us today for this interesting conversation. Holly also thanks APFED's Education Partners Bristol Myers Squibb, GSK, Sanofi, and Regeneron for supporting this episode.   Mentioned in This Episode: Dr. Wayne Shreffler, MD, Ph.D., Chief of Pediatric Allergy and Immunology and Co-Director of The Food Allergy Center at Massachusetts General Hospital “Triggers for eosinophilic esophagitis (EoE): The intersection of food allergy and EoE” Dr. Caitlin Burk Dr. David A. Hill   APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections   Education Partners: This episode of APFED's podcast is brought to you thanks to the support of Bristol Myers Squibb, GSK, Sanofi, and Regeneron.   Tweetables:   “This fascinating problem of food allergy: why does the immune system do that for some people — recognize what should be nutritive and innocuous sources of energy as an immunological trigger? ” — Dr. Wayne Shreffler   “A food allergy; because there is this IgE antibody, we can do skin tests. We can measure that in the blood. It's a useful marker for helping to identify which foods are the trigger.” — Dr. Wayne Shreffler   “EoE is tricky because there's not that clear and easy temporal association between an offending allergen exposure for most people and their symptoms. People don't associate the symptoms with the triggers.” — Dr. Wayne Shreffler   “Everything is shared decision-making. In some cases, it's a shared decision where I have a strong evidence-based opinion. In some cases, there's a lot more room for a range of clinical decisions that could be equally justified.” — Dr. Wayne Shreffler   “Steroids don't help with IgE-related food allergy. They're not effective at blocking that IgE-driven immediate response.” — Dr. Wayne Shreffler   “I'm trying to see what we can utilize from our research to make non-invasive tests to identify food allergen triggers for patients so they don't have to go through so many endoscopies. I think that's a huge unmet need.” — Dr. Wayne Shreffler  

Discover your best foods for optimal health with Dr. Derek Allessi. He uses medical tests on himself to see how his body reacts to different foods and substances. Find out how to prevent diabetes and other inflammatory diseases through diet.RESOURCES:Dr. Alessi's Nutrition Website:https://drhaley.com/strength-genesisDr. Alessi's Fitness Website:https://alessifit.com/Dr. Alessi's Facebook Page:https://www.facebook.com/strengthgenesisDr. Alessi on Instagram:https://www.instagram.com/strengthgenesisDr. Alessi on YouTube:https://www.youtube.com/channel/UCz66DxFGoZXMa-TZBw3SOswThis episodes Blog Page:https://drhaley.com/prevent-inflammation/Dr. Alessi, Author of The Bermuda Triangle Diet, Lose Fat Forever, and "The Promise Health and Fitness System has a doctorate degree in health and Physical education and a master's in nutrition. He is wwner and operator of Dr. Derek Health & Fitness in New York. He has appeared in hundreds of TV and radio programs throughout the country and is host of the weekly TV show on NBC Cleveland & NBC Buffalo, New York called "Live it Fit Now. In this episode on "The Dr. Haley Show Podcast, Dr. Alessi discusses health and fitness from every aspect with a focus on an anti-inflammatory diet and maintaining stable normal blood sugar levels.TIMESTAMPS:00:00 Intro Snip00:49 Introduce Dr. Derek Alessi02:12 What is "Strength Genesis"02:50 What is Macadamia Nut Oil.?05:45 What is the history of hydrogenated oils?08:39 Why do they call you "The High Octane Dad"?09:00 Dr. Alessi gets his windows cleaned10:44 What is "Black Ant Powder"?10:50 What is "Mouth Taping"?16:21 How many hours of deep sleep and how many hours of sleep do you need a night?18:00 Why are people so tired all of the time?20:23 What have you learned from measuring your glucose after certain foods?24:08 Is it better to drink wine or vodka?25:18 Why does the scripture tell you to drink wine?26:40 What do you mean that "when you eat, you are feeding them"?28:53 What peaked your interest in diet to the point where you chose this as your profession?30:53 What are your current diet goals?31:26 What do you eat to accomplish your diet goals?32:38 What happened to the bread over the years?35:01 What is wrong with seed oils?36:40 Why do we need more omega 3 fatty acids?36:06 What is the difference between the omega 3's and the omega 6 fatty acids?41:55 Why did you start selling Macadamia nut oil?44:53 What is in your keto salad dressing?45:28 What is a creatine chew?47:22 What are the benefits of creatine?48:02 What else helps with dementia?52:13 What is the best protein supplement?54:51 What is the difference between line caught and farmed fish?

Host: Darryl S. Chutka, M.D. [@chutkaMD] Guest: Vinaya Simha, M.B.B.S., M.D. Type 2 Diabetes is a commonly seen condition in a general medical practice. It's estimated that over 38 million adults have the disease. When we think of diabetes, we think of a metabolic condition with patients who have hyperglycemia, often overweight, and occasionally have renal, eye and/or neurologic complications. But, do we ever think of diabetes as an inflammatory disease? How is inflammation associated with diabetes? What are the mediators of inflammation in diabetics and when we treat diabetes, are we reducing the associated inflammation in addition to lowering blood glucose? These are questions I'll be asking our guest, Vinaya Simha, M.B.B.S., M.D., from the Division of Endocrinology and Metabolic Disease at the Mayo Clinic as we discuss “Type 2 Diabetes as an Inflammatory Disease”. These talks on Inflammation and Cardiometabolic Disease are sponsored by Novo Nordisk Learn more about this series HERE Connect with the Mayo Clinic's School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

Pelvic Inflammatory Disease (PID), a condition that affects many but is often misunderstood. In this episode, we'll explore the causes, symptoms, and treatment options for PID. Our experts will discuss the importance of early detection and how it can impact overall reproductive health. Whether you're seeking information for yourself or a loved one, this conversation aims to empower and educate. Listen for insights that promote awareness and support

How do prescribers and patients determine whether or not a treatment for psoriasis or eczema provides meaningful response? And what is the right way to make a therapeutic switch? Wendy Cantrell, DNP, CRNP; Joe Gorelick, MSN, FNP-C; David E. Cohen, MD, MPH; and Kara Gooding, MMS, PA-C discuss. Plus, Steve Hawkes, MMS, PA-C shares tips on isotretinoin and Suneel Chilukuri, MD, talks exosomes science.Like what you're hearing? Want to learn more about the Dermatology Education Foundation? Explore assets and resources on our website.

Let's explore the critical issue of Pelvic Inflammatory Disease (PID) and its impact on fertility. PID is an infection of the female reproductive organs that can lead to serious complications. Listen as we discuss the symptoms, long-term effects, and the importance of early diagnosis and treatment. Gain expert's insights on how Sleeping with more than one man with no protection can lead to PID

A 24-year-old adult, assigned female at birth, presents to your practice chief complaint of bilateral lower abdominal pain for the past three days, worsening over this time frame. She describes the pain as a heavy pressure like feeling, accompanied by intermittent fever , mild dysuria, yellow vaginal discharge, as well as nausea without vomiting nausea without vomiting. She is tolerating fluids well and has a markedly decreased appetite. Additional history of present illness includes recent LMP, ending about three days ago with normal timing and normal flow, she is sexually active with two male partners, and describes that the last episode of coitus six days ago was painful for deep pelvic discomfort. The physical exam reveals a temp of 100.4 Fahrenheit, rest of vital signs within normal limits, mild lower abdominal discomfort to light and deep palpation without rebound, yellow vaginal discharge and cervical motion tenderness without palpable pelvic mass. This clinical presentation is most consistent with:A. Acute AppendicitisB. Pelvic Inflammatory DiseaseC. Ovarian CystD. Ectopic Pregnancy---YouTube: https://www.youtube.com/watch?v=hS0zWLA9b_A&list=PLf0PFEPBXfq592b5zCthlxSNIEM-H-EtD&index=86Visit fhea.com to learn more!

In this episode, we review the high-yield topic of ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Pelvic Inflammatory Disease (PID) ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Gynecology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets

In the October episode of Critical Decisions in Emergency Medicine, Drs. Danya Khoujah and Wendy Chang discuss opportunistic infections in patients with HIV and presentations of pelvic inflammatory disease. As always, you'll hear about the hot topics covered in CDEM's regular features, including a winged scapula in Clinical Pediatrics, a die-punch fracture of the distal radius in Critical Cases in Orthopedics and Trauma, manual reduction of paraphimosis in The Critical Procedure, early anticoagulant reversal after trauma in the LLSA Literature Review, and a critically ill patient in The Critical Image.

Join us for the latest axSpA podcast brought to you by the Immune-mediated Inflammatory Disease forum! This month, Dr Sofia Ramiro is joined by Professors Hideto Kameda, Atul Deodhar and Xenofon Baraliakos to discuss the long-term etanercept response in patients with radiographic axSpA and the comparison of tofacitinib and adalimumab in a real-world clinical context.

Do you sometimes feel tired or even sick after eating? Did you know it could be because of inflammation? Lisa continues the conversation today with our guest Dr. Tom O'Bryan who is an expert in food sensitivities and the way they affect our lives.   Did you know that bodies can attack themselves when we are eating the wrong foods?  Dr. Tom has extensively researched inflammatory disease and the root mechanism behind disease. The Center for Disease Control reports that 14 out of the top 15 causes of disease are caused by chronic inflammation. He talks about how excessive inflammation is extremely dangerous and how wheat and dairy can be so unhealthy, along with lectins, soy, and corn.   Dr. O'Bryan and his colleagues have debuted a new docuseries called “The Inflammation Equation: Decoding the Path to Optimal Well Being.”  This series contains interviews and information from 80 experts and physicians worldwide. For info about Dr. Tom O'Bryan and to find out more about “The Inflammation Equation,” visit TheDr.com and https://rkt511.isrefer.com/go/tie24/theawareshow.   The most common source of inflammation is a result of the foods we eat. Lisa asks about the elimination diet and how soon we can begin to feel better. If your immune system is fighting a food, and you eliminate it, you will begin to feel better within 3 weeks.   Dr. Tom talks about how many people suffer from low-grade edema and discusses how your body holds onto water. He talks about gluten-free foods and how they are essentially just white paste. He talks about Celiac disease and how changing your diet must be done correctly.  The Mediterranean diet has been touted to be one of the healthiest. It includes water, as well as fruit and vegetables. He suggests eating at least 50 different fruits and vegetables a week, including root vegetables.   Himalayan buckwheat has been shown to be extremely beneficial for health. Spices and good fats, such as extra virgin olive oil, are also important. Finally, small portions of fish and poultry of good quality are important as well. This feeds your microbiome in a healthy way.   He also discusses the difference between European wheat  and American wheat. This is because of lectins in the wheat. You may not have gut symptoms if you eat wheat in Europe, but you are still activating the immune response. He further discusses his docuseries, “The Inflammation Equation: Decoding the Path to Optimal Well Being.”  This series contains interviews and information from 80 experts and physicians worldwide. This is Part 2 of the interview. For info about Dr Tom O'Bryan and to find out more about “The Inflammation Equation,” visit TheDr.com and  https://rkt511.isrefer.com/go/tie24/theawareshow.  

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: John Stone, MD, MPH Glucocorticoids are often successfully used as the mainstay of treatment for many inflammatory conditions, but adverse events associated with glucocorticoids use are common. Fortunately, there are steps we can take to reduce the risk of glucocorticoid toxicity, like monitoring patients, educating them on the possible side effects, and considering alternative treatments where available. Tune in to learn more about the side effects, risk factors, and prevention strategies with Dr. Charles Turck and Dr. John Stone. © 2024 Sanofi and Regeneron Pharmaceuticals, Inc. All rights reserved. MAT-US-2310647 v1.0 - PExpiration Date 04/16/2025

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: John Stone, MD, MPH Glucocorticoids are often successfully used as the mainstay of treatment for many inflammatory conditions, but adverse events associated with glucocorticoids use are common. Fortunately, there are steps we can take to reduce the risk of glucocorticoid toxicity, like monitoring patients, educating them on the possible side effects, and considering alternative treatments where available. Tune in to learn more about the side effects, risk factors, and prevention strategies with Dr. Charles Turck and Dr. John Stone. © 2024 Sanofi and Regeneron Pharmaceuticals, Inc. All rights reserved. MAT-US-2310647 v1.0 - PExpiration Date 04/16/2025

Do you sometimes feel unwell after a meal? Are you tired or fatigued after eating? Did you know it could be a food allergy or inflammation? Our guest today is Dr. Tom O'Bryan who is an expert in food sensitivities and the way they affect our lives. Our body can attack itself when we are eating the wrong foods and cause inflammation.   The Center for Disease Control reports that 14 out of the top 15 causes of disease are caused by chronic inflammation.   But what is inflammation? And is it always bad for you? Dr. Tom has extensively researched inflammatory disease and the root mechanism behind disease. So, how do you reduce inflammation?   Dr. O'Bryan and his colleagues have debuted a new docuseries called “The Inflammation Equation: Decoding the Path to Optimal Well Being.”  This series contains interviews and information from 80 experts and physicians worldwide. For info about Dr. Tom O'Bryan and to find out more about “The Inflammation Equation,” visit TheDr.com and https://rkt511.isrefer.com/go/tie24/theawareshow.   In today's interview, he explains how we have very little bacteria when we are born, yet we die with 90% bacteria according to experts. Our microbiome changes due to our environment.  Dr. Tom shares a personal story about the birth of his son and the microbiome he was born with during an emergency C-section. He also talks about the components of breast milk and the way it affects the baby.   We must always put emphasis on a healthy microbiome. Depending on the type of bacteria you have, you may not feel well physically or mentally. You may be depressed or feeling anxiety. This is influenced by what's in your gut's microbiome. This tells the body how to function, digest, think, and so much more. He talks about metabolism and the blood stream, which activates your genes and how it is all affected by the microbiome. Inflammation can be activated.   According to Dr. Tom, we go from health to disfunction, then to disease. It's always inflammation causing this. When brain fog starts, when you forget where you parked, or where you left your keys, you may be heading down the path of disease. In fact, there is a 400% increase in Alzheimer's in younger people, based on studies over the last four years. This is completely from chronic inflammation. There's new information for Baby Boomers, as well as women of childbearing age. The incidents of autism are skyrocketing as well as children on antidepressants. This can also be because of plastics found in so many places such as water bottles. Yet, there is hope and we can learn what our bodies need to be healthy. Once again, for info about Dr. Tom O'Bryan and to watch “The Inflammation Equation,” visit TheDr.com and https://rkt511.isrefer.com/go/tie24/theawareshow.

Join us for the latest axSpA podcast brought to you by the Immune-mediated Inflammatory Disease forum! This month Dr Sofia Ramiro is joined by Professors Hideto Kameda and Atul Deodhar to discuss the retention rate of secukinumab over two different time periods. Our faculty then move on to discuss another publication, which compares the improvements is sacroiliac joint symptoms across patients with AS and axSpA treated with different DMARDs.

In this episode, we review the high-yield topic of ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Microbiology of Pelvic Inflammatory Disease⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠from the Microbiology section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets

Do you sometimes feel unwell after eating? Did you know it could be a food allergy or inflammation? Lisa continues the conversation today with our guest Dr. Tom O'Bryan who is an expert in food sensitivities and the way they affect our lives.   Did you know that your body can attack itself when you are eating the wrong foods?  Dr. Tom has extensively researched inflammatory disease and the root mechanism behind disease. The Center for Disease Control reports that 14 out of the top 15 causes of disease are caused by chronic inflammation. He talks about how excessive inflammation is extremely dangerous and how wheat and dairy can be so unhealthy, along with lectins, soy, and corn.   The most common source of inflammation is a result of the foods we eat. Lisa asks about the elimination diet and how soon we can begin to feel better. If your immune system is fighting a food, and you eliminate it, you will begin to feel better within 3 weeks.   Dr. Tom talks about how many people suffer from low-grade edema and discusses how your body holds onto water. He talks about gluten-free foods and how they are essentially just white paste. He talks about Celiac disease and how changing your diet must be done correctly.  The Mediterranean diet has been touted to be one of the healthiest. It includes water, as well as fruit and vegetables. He suggests eating at least 50 different fruits and vegetables a week, including root vegetables.   Himalayan buckwheat has been shown to be extremely beneficial for health. Spices and good fats, such as extra virgin olive oil, are also important. Finally, small portions of fish and poultry of good quality are important as well. This feeds your microbiome in a healthy way.   He also discusses the difference between European wheat  and American wheat. This is because of lectins in the wheat. You may not have gut symptoms if you eat wheat in Europe, but you are still activating the immune response. He further discusses his upcoming docuseries, “The Inflammation Equation: Decoding the Path to Optimal Well Being.”  This series contains interviews and information from 80 experts and physicians worldwide. This is Part 2 of the interview. For info about Dr Tom O'Bryan and to find out more about “The Inflammation Equation,” visit TheDr.com and  https://rkt511.isrefer.com/go/tie24/theawareshow.

Join us for the latest axSpA podcast brought to you by the Immune-mediated Inflammatory Disease forum! This month Dr Sofia Ramiro is joined by Professors Hideto Kameda, Atul Deodhar and Xenofon Baraliakos to discuss the risk of acute anterior uveitis across different bDMARDs in patients with AS. Our faculty then move on to discuss another publication, which compares patient-reported outcomes (PROs) and 24-month retention rates between patients with axSpA and PsA that were treated with secukinumab.

 Are you tired or fatigued after eating? Do you sometimes feel unwell after a meal? Did you know it could be a food allergy or inflammation? Our guest today is Dr. Tom O'Bryan who is an expert in food sensitivities and the way they affect our lives. Our body can attack itself when we are eating the wrong foods.   Dr. Tom has extensively researched inflammatory disease and the root mechanism behind disease. The Center for Disease Control reports that 14 out of the top 15 causes of disease are caused by chronic inflammation. But what is inflammation? And is it always bad for you? He talks about how excessive inflammation is extremely dangerous.   He explains how we have very little bacteria when we are born, yet we die with 90% bacteria according to experts. Our microbiome changes due to our environment.  Dr. Tom shares a personal story about the birth of his son and the microbiome he was born with during an emergency C-section. He also talks about the components of breast milk and the way it affects the baby. We must always put emphasis on a healthy microbiome. Depending on the type of bacteria you have, you may not feel well physically or mentally. You may be depressed or feeling anxiety. This is influenced by what's in your gut's microbiome. This tells the body how to function, digest, think, and so much more. He talks about metabolism and the blood stream, which activates your genes and how it is all affected by the microbiome. Inflammation can be activated.   So, how do you reduce inflammation? Dr. O'Bryan and his colleagues are working on a new docuseries called “The Inflammation Equation: Decoding the Path to Optimal Well Being.”  This series contains interviews and information from 80 experts and physicians worldwide.   According to Dr. Tom, we go from health to disfunction, then to disease. It's always inflammation causing this. When brain fog starts, when you forget where you parked, or where you left your keys, you may be heading down the path of disease. In fact, there is a 400% increase in Alzheimer's in younger people, based on studies over the last four years. This is completely from chronic inflammation. There's new information for Baby Boomers, as well as women of childbearing age. The incidents of autism are skyrocketing as well as children on antidepressants. This can also be because of plastics found in so many places such as water bottles. Yet, there is hope and we can learn what our bodies need to be healthy. This is Part 1 of the interview. For info about Dr. Tom O'Bryan and to find out more about “The Inflammation Equation,” visit TheDr.com and https://rkt511.isrefer.com/go/tie24/theawareshow

This episode features an interview with Amir Reichman, CEO of Scinai Immunotherapeutics, a biopharma company focused on developing, manufacturing and commercializing cutting-edge biological treatments within the inflammation and immunology (I&I) sector, with a primary focus on addressing autoimmune and infectious diseases.Scinai Immunotherapeutics is working on developing nanosized antibodies from alpacas, known as VHH-antibodies or NanoAbs, which show promise as improved biological therapies for various illnesses. These NanoAbs are being tailored to treat conditions with significant unmet medical requirements and promising market prospects, including psoriasis and asthma.Prior to being appointed as Scinai's CEO in 2021, Mr. Reichman recently held the position of Head of Global Vaccines Engineering Core Technologies and Asset Management at the GSK Vaccines headquarters in Belgium. Before that, he was the Senior Director of the Global GSK Vaccines Supply Chain. He became part of GSK in 2015 following its acquisition of Novartis Vaccines, where he had various leadership positions with growing responsibilities within the Global Vaccines Supply Chain Management team, based in Holly Springs, NC, USA.Tune into the episode to hear more about the development of new, cutting-edge inflammation and immunology therapies. Mr. Reichman also shares insights into the most significant trends currently shaping the inflammation and immunology sector.For more life science and medical device content, visit the Xtalks Vitals homepage.Follow Us on Social MediaTwitter: @Xtalks Instagram: @Xtalks Facebook: https://www.facebook.com/Xtalks.Webinars/ LinkedIn: https://www.linkedin.com/company/xtalks-webconferences YouTube: https://www.youtube.com/c/XtalksWebinars/featured

This episode features an interview with Punit Dhillon, Chairman & CEO of Skye Bioscience, a pharmaceutical company developing proprietary molecules to treat diseases involving inflammatory, fibrotic and metabolic conditions. Skye Bioscience is at the forefront of exploring the endocannabinoid system for drug development.Punit brings two decades of experience as a leader and investor within the life sciences sector. During the interview, he shared his journey leading up to his role at Skye Bioscience and how his previous experiences have shaped his vision for the company.During the interview, Punit discussed Skye Bioscience's mission and therapeutic approach. The company is aiming to unlock the medicinal possibilities of the endocannabinoid system for addressing diseases that lack adequate treatments for patients globally.At the end of the interview, Punit shared some advice for those looking to venture into the biotech and pharmaceutical industry.For more life science and medical device content, visit the Xtalks Vitals homepage.Follow Us on Social MediaTwitter: @Xtalks Instagram: @Xtalks Facebook: https://www.facebook.com/Xtalks.Webinars/ LinkedIn: https://www.linkedin.com/company/xtalks-webconferences YouTube: https://www.youtube.com/c/XtalksWebinars/featured

Join us for the latest axSpA podcast brought to you by the Immune-mediated Inflammatory Disease forum! This month Dr Sofia Ramiro is joined by Professors Hideto Kameda and Xenofon Baraliakos to discuss the long-term impact of secukinumab treatment on bone-related outcomes and BTMs in r-AxSpA patients over two years. Our faculty then move on to discuss another publication, which presents JAKi treatment recommendations for IMIDs from a two-round modified RAM study with 21 subject matter experts.

Dr. Artemis Simopoulos is a physician and researcher specializing in endocrinology, nutrition, and metabolic health. They discuss: traditional hunter-gatherer diets vs. modern Western diets; dietary fats; omega-6 and omega-3 polyunsaturated fats; sucrose & sugar; chronic inflammatory diseases, obesity & diabetes; vegetable & seed oils vs. other cooking oils; processed foods; fish oil supplements; and more.Download a free digital copy of her book: https://www.mdpi.com/books/mono/5908-the-healthiest-diet-for-you-scientific-aspectsMore content on the science of diet & metabolic health: https://substack.com/search/diet%20metabolism?focusedPublicationId=513528&searching=focused_postsSupport the showSign up for the free weekly Mind & Matter newsletter:[https://mindandmatter.substack.com/?sort=top]Learn how you can further support the podcast: [https://mindandmatter.substack.com/p/how-to-support-mind-and-matter]Become a Premium Subscriber to access full content library, including full premium episodes:[https://mindandmatter.substack.com/subscribe?utm_source=menu&simple=true&next=https%3A%2F%2Fmindandmatter.substack.com%2F]Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off:[https://www.lumen.me/shop?fid=8731&utm_source=influencer&utm_medium=influencer&discount=MIND]

Robert L. Beckman, Ph.D., is the co-founder and executive director of TreatNOW.org - a group of citizens, veterans, institutions and service organization working pro bono to help brain injured troops and others suffering from concussions, traumatic brain injury (TBI), and post traumatic stress disorder (PTSD). They have helped treat and heal over 21,000 brain wounded individuals. Dr. Beckman has been building knowledge management systems most of his professional career, primarily in the Intelligence Community and DOD. He is a former USAF KC-135 pilot and a Vietnam Veteran.  He is also the Chief Knowledge Officer, Foundation for the Study of Inflammatory Disease. ***Support the showFollow the Greg Krino Show here...GregKrino.comYouTubeInstagramFacebookTwitterLinkedInIf you enjoyed the podcast, please leave a 5-star rating and friendly comment on your podcast app. It takes only a minute, and it really helps convince popular guests to join me.If you have comments or ideas for the show, please contact me at gregkrinoshow@gmail.com.Support the showSupport the show

On today's show, Robert Beckman discusses ptsd, brain injuries, preventing veteran suicides and effective therapies.  GUEST OVERVIEW: Dr Robert Beckman is a PhD holder in nuclear non proliferation. As such his specialty suits him perfectly for projects aimed at avoiding or mitigating massive loss of both human life and the loss of prodigious economic resources. One such project is specially connected to 9/11 and its aftermath namely advocating for and helping deeply impacted men and women, affected by brain injuries and PTSD. He has stepped up to the massive task as Co-Founder and Executive Director of TreatNOW which has a as a mission to Stop service member suicides by identifying and treating veterans and others suffering from brain wounds. Dr. Beckman is a former USAF KC-135 pilot and a Vietnam Veteran. He is also the Chief Knowledge Officer for the Foundation for the Study of Inflammatory Disease. His website is: www.treatnow.org/

The National Security Hour with LTC Sargis Sangari USA (Ret.) – Dr. Robert Beckman, C-Founder, Executive Director of TreatNOW.org, and Chief Knowledge Officer at the Foundation for the Study of Inflammatory Disease (foundsid.org), joins me to discuss the lingering effects of Traumatic Brain Injury (TBI) & Post-traumatic stress disorder (PTSD) and the means and the multiple ways of new treatments to address them.

Follow along while you listen to this show!   Just head over to nclexbook.com to get our Free eBook -  NCLEX Flash Notes, with 77- MUST KNOW NCLEX nursing topics . . . and as a bonus, you'll receive 16 full-color nursing cheatsheet.   www.nclexbook.com Pelvic Inflammatory Disease (PID) Flash Notes - The Best Way to Prep for NCLEX  Pelvic Inflammatory Disease (PID) is pelvic inflammatory disease is an infection of the female reproductive tract, it's caused by alterations in the cervical mucus, which can be fatal if untreated. Master questions on Pelvic Inflammatory Disease (PID) with this clear and concise content that will help you conquer the NCLEX exam. www.nclexbook.com  

Alison shares her decades-long struggle living with an undiagnosed auto-inflammatory disease and a myriad of other chronic health conditions. Diagnosed with Crohn's disease at age 7, she began suffering from extreme gastrointestinal symptoms and complications that have continued into adulthood. However, Alison also experiences many perplexing symptoms unrelated to her Crohn's, including severe fatigue, migrating arthritic pain, Raynaud's phenomenon, and random inflammation flare-ups on her body triggered by stress. Despite endless tests and specialist referrals, the source of these strange symptoms continues to evade diagnosis.In this emotional episode, Alison opens up about her childhood blockage from Crohn's medications, the isolation of dealing with chronic illness as a kid, being dismissed by doctors, and the frustration of unexplained symptoms. She also shares how her health impacts dating, work, and everyday life. After decades without answers, Alison has a new referral to the National Institutes of Health, which offers hope for finally discovering what auto-inflammatory condition may be behind her myriad of symptoms. Hashtags: #AutoInflammatoryDisease #Undiagnosed #ChronicIllness #CrohnsDisease #Arthritis #Disability #RareDisease #InvisibleIllness #Spoonie #YoungPeopleWithLupus #RheumatoidArthritis #Health #Wellness #PatientStory #MedicalJourney #Advocate

In this episode, we review the high-yield topic of Pelvic Inflammatory Disease (PID) ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠from the Reproductive section. Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message

In this part 2 of our 2-part series on STIs with Dr. Catherine Varner and Dr. Robyn Shafer we answer such questions as: Why should we care about making the diagnosis of pelvic inflammatory disease (PID) in the ED? What combination of clinical features and lab tests should trigger a presumptive diagnosis and empiric treatment of PID? Which patients with PID require admission to hospital? What are the test characteristics of ultrasound for the diagnosis of PID and for Fitz-Hugh-Curtis Syndrome? When and how should we work up  patients for syphilis in the ED? When should we suspect and empirically treat for lymphogranuloma venereum and granuloma inguinale? does an IUD need to be removed in patients with PID? and many more... The post Ep 183 STIs: Pelvic Inflammatory Disease and Genital Lesions – HSV, Syphilis and LVG appeared first on Emergency Medicine Cases.

We've had to update yet again! Guess this is what happens when you run a podcast on Ob/Gyn for almost 5 years. Today, we review some updates by the CDC on pelvic inflammatory disease. What is it? How do we treat it? Have the antibiotics regimens changed? Find out on today's episode!  Check out the website for the Rosh Review question of the week.  Twitter: @creogsovercoff1 Instagram: @creogsovercoffee Facebook: www.facebook.com/creogsovercoffee Website: www.creogsovercoffee.com Patreon: www.patreon.com/creogsovercoffee You can find the OBG Project at: www.obgproject.com

Listen in for a great review with Dr. Sarah Wood (CHOP) about how to diagnose pelvic inflammatory disease, including tips on how to perform a pelvic exam, and what to do when your treatment for PID isn't working. 

Synopsis: Tariq Kassum, M.D. is the CEO of Celsius Therapeutics, a company pioneering new precision medicines in inflammatory disease by harnessing the power of single-cell RNA sequencing and human biology at scale. Tariq shares his unique journey from med school, to working in Wall Street as a biotech investment banker and stock analyst, to the corporate side working at Millennium Pharmaceuticals and Takeda, and finally the innovative biotech world. He discusses the importance of learning to adapt to each environment in order to remain productive and successful, and building meaningful relationships with coworkers and mentors. He also talks about what it will take for the biopharma executive of the future to be successful. Biography: Tariq Kassum brings 20 years of experience in corporate development, strategy and business leadership to Celsius. He joined the company in 2019 from Obsidian Therapeutics, where he was a co-founder and served as chief operating officer and head of corporate development. During this time, Tariq helped build Obsidian into a leading platform technology company and played a central role in the company's strategic partnership with Celgene. Prior to Obsidian, Tariq spent seven years with Millennium Pharmaceuticals and Takeda, most recently as vice president, business development and strategy for Takeda Oncology, responsible for transactions, collaborations, alliance management and strategic planning. Before that, he led Takeda's global corporate development efforts, where he managed multiple acquisitions and divestitures in the U.S. and internationally. He was also part of the business development team at Millennium Pharmaceuticals. Prior to Takeda, Tariq was an analyst covering healthcare equities for institutional investment firms, where he led scientific due diligence and investment decisions on numerous companies and pharmaceutical compounds across multiple therapeutic areas. He began his career as an investment banker with CIBC World Markets, serving clients in the biotechnology and specialty pharmaceuticals industries.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.06.527402v1?rss=1 Authors: Yu, B. Abstract: Objective: To facilitate in vitro mechanistic studies in pelvic inflammatory disease (PID) and subsequent tubal factor infertility, as well as ovarian carcinogenesis, we sought to establish patient tissue derived fallopian tube (FT) organoids and to study their inflammatory response to acute vaginal bacterial infection. Design: Experimental study. Setting: Academic medical and research center. Patients: FT tissues were obtained from four patients after salpingectomy for benign gynecological diseases. Interventions: We introduced acute infection in the FT organoid culture system by inoculating the organoid culture media with two common vaginal bacterial species, Lactobacillus crispatus and Fannyhessea vaginae. Main Outcome Measures: The inflammatory response elicited in the organoids after acute bacterial infection was analyzed by the expression profile of 249 inflammatory genes. Results: Compared to the negative controls that were not cultured with any bacteria, the organoids cultured with either bacterial species showed multiple differentially expressed inflammatory genes. Marked differences were noted between the Lactobacillus crispatus infected organoids and those infected by Fannyhessea vaginae. Genes from the C-X-C motif chemokine ligand (CXCL) family were highly upregulated in F. vaginae infected organoids. Flow cytometry showed that immune cells quickly disappeared during the organoid culture, indicating the inflammatory response observed with bacterial culture was generated by the epithelial cells in the organoids. Conclusion: Patient tissue derived FT organoids respond to acute bacterial infection with upregulation of inflammatory genes specific to different vaginal bacterial species. FT organoids is a useful model system to study the host-pathogen interaction during bacterial infection which may facilitate mechanistic investigations in PID and its contribution to tubal factor infertility and ovarian carcinogensis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Rupa Marya is a physician, activist, artist and writer. She is an Associate Professor of Medicine at the University of California, San Francisco, founder and director of the Deep Medicine Circle, and co-author of Inflamed: Deep Medicine and The Anatomy of Injustice. She sits down with Dylan Heuer to discuss the connections she sees between colonization and contemporary afflictions like the disproportionate harm caused by Covid-19. She draws on Indigenous knowledge to advocate for a more holistic approach to wellbeing that includes treating farmers as stewards of our health and involving doctors in social justice organizing.HRN is back "On Tour" thanks , in part, to the generous support of the Julia Child Foundation.HRN On Tour is powered by Simplecast.

In our inaugural episode we welcome Dr Monica Yang, lead author for "Reactogenicity of the Messenger RNA SARS–CoV-2 Vaccines Associated With Immunogenicity in Patients With Autoimmune and Inflammatory Disease" and Dr. Maria Danila the Associate Editor for the manuscript. We discuss some of the findings their COVID19 Vaccine Response in Patients with Autoimmune Disease (COVARiPAD) study found, deeply dive into the data that supports their findings and ask what was involved in putting this manuscript together, which eventually led to its publishing in "Arthritis Care and Research"

This episode covers pelvic inflammatory disease.Written notes can be found at https://zerotofinals.com/obgyn/gum/pid/ or in the genitourinary medicine section of the Zero to Finals obstetrics and gynaecology book.The audio in the episode was expertly edited by Harry Watchman.

Join Dr Neil Skolnik and Dr Ethan Craig as they discuss the underlying biological processes in axSpA Dr Skolnik is an academic family physician at Abington Jefferson Health in Abington, Pennsylvania Dr Craig is a rheumatologist at the University of Pennsylvania This podcast is sponsored by Novartis Medical Affairs, and the speakers have been compensated for their time. This podcast is part of the Think Back: Insights Into Axial Spondyloarthritis curriculum.

Want to experience the greatest in board studying? Check out our interactive question bank podcast- the FIRST of its kind here: emrapidbombs.supercast.com. Abstract abdominal pain complaint, no good diagnostic test, unreliable presentation. Sounds like the perfect storm for a tricky diagnosis. Let's talk presentation, diagnosis, pitfalls, and management of PID.

Arthritis is a severe disease that's uncomfortable at best and debilitating at worst. It is a leading cause of disability worldwide. Most people think that arthritis only happens to the elderly, but it can affect anyone. It is a disease that begins in your 20s or results from injuries sustained as a child. Unfortunately, most of what the general public is misinformed about arthritis: what it is, how it starts, and how to treat it! In this episode, Dr Elizabeth Yurth addresses common misconceptions about arthritis. She defines the disease and offers realistic alternatives to established treatment options. If you want to learn more about longevity-based proactive measures to address arthritis, this episode is for you! Here are three reasons why you should listen to the full episode: Recognise arthritis as an inflammatory process rather than a wear-and-tear disease. Understand the importance of addressing arthritis early on — as early as your 20s! Learn how longevity studies-based supplements and treatments improve the immune system and combat arthritis. Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world? Then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Episode Highlights [03:30] Breaking the Misconceptions about Arthritis Arthritis is more than a wear-and-tear condition; it's an inflammatory disease process.  It is not limited to the elderly. The disease process can begin with minor injuries, even those sustained as a child. Arthritis is a combination of genetics and environmental factors triggered by trauma.  [08:25] Arthritis as an Inflammatory Disease Process   Arthritis is a disease process like neurodegenerative and cardiac illnesses.  Our bodies follow a balanced way to deal with injuries. It releases the level of cytokines that set off the body's response to healing and recovery. Afterwards, cytokine levels fall, and anti-inflammatory proteins take over. The disease process begins during Imbalance in any part of the process. It can be started as too many cytokines lead to zombie cells and lack of autophagy. [12:20] General Approaches to Addressing Arthritis  Turn off inflammatory cytokines through simple supplements like curcumin or epigallocatechin.  Turning down the inflammatory response allows the injury to heal better.  Inducing autophagy or knocking off the bad cells helps reduce injury as well.  [13:36]  Arthritis is a Preventable Disease  Arthritis is a disease that should be given more attention, as it has a significant impact on people's quality of life. It is the primary cause of disability among people of working age.  Arthritis is preventable to a large degree, despite genetics and other factors.  [18:32] Current Orthopedic Treatments for Arthritis  The focus in addressing arthritis is to treat the disease process. Steroid injections temporarily reduce inflammatory cytokines, but they also inhibit those that aid in healing. Arthroscopic surgery can provide immediate comfort. However, it can also inflict tears that can cause the rapid progression of arthritis. Back fusion can help cases of spinal instability. However, for degenerative discs, the long-term success rate of surgery is around 10% of those who undergo it. [24:09]  Degenerative Disc Disease as an Inflammatory Disease  Degenerative disc disease is an inflammatory disease caused by high levels of cytokines. This includes the nuclear factor kappa beta. The goal is to focus on the issues that cause disc destruction, such as elevated cytokine levels, rather than the disc itself. Ageing processes, like degeneration, should serve as a wake-up call to reconsider one's diet. This also includes reconsidering supplements, and exercise, as well as one's cardiovascular health. [27:18]  Changing the Perspective about Arthritis People should be aware that arthritis begins in their 20s, similar to brain disorders, heart ailments, and cancers.    All these immune and inflammatory diseases come down to curing ageing.  We need to take proactive steps and opt for longevity instead of a mechanical standard of care.  Opting for the ‘expensive' care earlier will save you time, stress, and money. People often exhaust traditional options first before pursuing longevity treatments.  [38:49] Pentosan Polysulfate: ‘A Cure for Arthritis' Pentosan polysulfate is a repurposed drug that reduces cytokines causing degenerative disc pain.  According to studies, even after just six weeks of using Pentosan Polysulfate, you can continue to reap the advantages for up to a year. [45:07] Vitamins and Supplements to Combat Arthritis  Another strategy to fight arthritis is to make sure your nutrients are optimised. Vitamins D and C, and zinc are critical but straightforward micronutrients. Epigallocatechin gallate, or EGCG, has many benefits that aid in addressing arthritis. Its benefits include muscle-building, fat loss, and myostatin blocking. [47:07] Benefits of Gaining Muscle Muscle, as an organ, produces endocrine glands, and myokines have very beneficial effects on joints.   Those with sarcopenia or muscle loss are more likely to develop joint arthritis. Electrical stimulation of muscles can be done for individuals who are further along in a disease process. Static contraction or contracting the muscles for three seconds every hour also helps muscle-building.  [51:03]  Inducing Autophagy Process Using Spermidine  Spermidine is a polyamine compound that comes from bacteria in certain foods.  Polyamine is produced by the human body as well. However, as we become older, we make less of it. It is an autophagy-Inducing agent that aids in getting rid of damaged cells.  Spermidine works better than steroids at reducing inflammation. It preserves the joints without making them worse. [54:06] Trehalose: The ‘Sugar Substitute' Trehalose is glucose that impacts oxidative stress and helps clean up the cells.  It has zero glycemic impact, which helps blood glucose under control.  Trehalose is looked at for neurodegenerative diseases but can benefit joint pain.  [56:57] Peptide Therapies as Simple, Inexpensive Aid  If you are looking for simple, inexpensive aid, collagen peptides can also be beneficial.  They typically are part of a mixture including Vitamin C, which helps cartilage cells.  A more expensive option is aggressive peptides, like BPC 157 or Body Protection Compound 157. These peptides can aid joint regeneration. It's vital to understand the role of inflammation in arthritis rather than jumping at treatments, like stem cell therapy. [59:54] The Role of Stressed Immune System  Almost every disease is related to over-aggressive, pro-inflammatory cytokines, disruption in mitochondrial function, and autophagy.  Ageing causes a significant number of diseases.  The immune system goes awry for many reasons, including viral exposures. [59:54] Antiviral Drugs, Hormones, and Fasting Antiviral drugs, hormones, and fasting can help the immune system fight diseases as healthy as possible.  EGCG and curcumin are natural compounds that have some antiviral properties. Acyclovir is also a safe choice for combatting the herpes virus and Epstein-Barr, among others.   Our immune system produces fewer hormones as we become older. Our bodies need hormones to function, so we need to replace them somehow. Hormones have huge immune-modulating properties that help stop oxidative stress.  The immune system benefits from the recovery period following a fast. It can be very beneficial to clear out dead cells. [1:08:55] Rapamycin and Metformin: The ‘Future' of Arthritis Rapamycin is a chemotherapeutic medication with a solid immune-modulating effect.  It is well-known for activating autophagy, which can lengthen lifespan in all mammalian species scientists have studied. Metformin is an inexpensive medication that keeps glucose control.  It has some interesting studies on arthritis. One study shows the overlapping benefits in cardiovascular, renal, cancer, and obesity protection.  7 Powerful Quotes “[Arthritis as an inflammatory disease process] is the same thing that goes on with COVID. Right? Yes. Why do some people die of COVID? [It's] usually not the virus itself -- it's the immune reaction to the virus.”   “So we know we have to treat [cytokines] and not the disc itself. That's the end game. Treat the problem that's causing the disc damage.”   “...[W]e're really trying to get into the heads of these [20-year-olds] and say, the [disease process starts when you're] 20. Yeah, like your brain diseases, your heart diseases, and your cancers are all those processes are starting in our 20s.”   “The plastic surgeons are doing fine. [P]eople are more than willing to spend that money on their facelifts and things like that [than] internally to feel better.”   “You can have no cartilage and no pain or no discs, and no gain. The pain is an inflammatory sign.” “Go back, go back up the tree. And then you had all of the diseases in mitochondria and information.” "Be it cancer, metabolic disease, cardiovascular disease, or neurologic arthritis, they're all the same disease. You've got to get the immune system as healthy as possible. You have to stop oxidative stress." Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Track your blood glucose in real-time with Levels Health.  Tripping Over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine's Most Entrenched Paradigms by Travis Christofferson  Curable: How an Unlikely Group of Radical Innovators is Trying to Transform our Health Care System by Travis Christofferson  How to Starve Cancer by Jane McLelland Want to learn more from Dr Dom? Check out Peter Attia's podcast episodes with him:  Episode 116 - AMA with Dom D'Agostino, PhD, Part I of II: Ketogenic diet, exogenous ketones, and exercise Episode 120 – AMA with Dom D'Agostino, PhD, Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health  Episode 5 - Dom D'Agostino, PhD: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer       You can also check out other podcasts where Dr Dom was a guest here.  The 1-Week and 8-Month Effects of a Ketogenic Diet or Ketone Salt Supplementation on Multi-Organ Markers of Oxidative Stress and Mitochondrial Function in Rats  Press-pulse: a novel therapeutic strategy for the metabolic management of cancer  Ketone supplementation decreases tumour cell viability and prolongs the survival of mice with metastatic cancer  Moffitt Cancer Center  Get your exogenous ketones from Audacious Nutrition  Keto Nutrition: Website | Youtube | Instagram | Facebook Connect with Dr Dom: Twitter | LinkedIn | Instagram About Dr Elizabeth Dr Elizabeth Yurth, MD, FAARFM, ABAARM is a practising orthopedic. She specialises in sports, spine, and regenerative medicine and has over 25 years of professional experience as a practising orthopaedic physician. She is a double-Board Certified in Physical Medicine & Rehabilitation and Anti-Aging/Regenerative Medicine.  Dr Yurth has dedicated her life to longevity. In 2006, she founded the Boulder Longevity Institute, where she serves as the Medical Director. She has worked as the team physician for Stanford and Santa Clara Universities and consulted for the San Francisco 49ers and the San Jose Ballet. Dr Yurth has a dual-Fellowship in Anti-Aging and Regenerative Medicine (FAARM), and Anti-Aging, Regenerative and Functional Medicine (FAARFM) through the American Academy of Anti-Aging Medicine (A4M). She recently completed a Fellowship in Human Potential and Epigenetic Medicine.  You can learn more and connect with Dr Elizabeth on Twitter, LinkedIn, and Instagram. Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can know how to optimise sleep.  Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa  

04/04/2022 | CT of the Small Bowel: Inflammatory Disease - Part 2

03/28/2022 | CT of the Small Bowel: Inflammatory Disease - Part 1

Why has Gout been an incredibly challenging condition for many individuals to treat? Even though treatments have been developed and used, Gout flares can remain, being an incredibly painful and diminishing quality of life. Listen up to learn: the predominant problem for patients with Gout the specific gene that should be tested for Why Gout tophi can cause issues Nihar Bhakta, the CMO of Aristea Therapeutics, speaks about treating Gout and giving patients lasting relief. Gout has long troubled patients, causing severe inflammatory reactions and limiting motion and quality of life. However, lowering uric acid is the primary treatment method and can remain challenging for some patients. If patients are mistreated over time, they can go on to develop kidney issues, which may even begin to turn chronic. Hopefully, with further development, Aristea and a handful of other companies can produce treatments to reduce uric acid while limiting possible adverse effects. Visit https://aristeatx.com to learn more. Episode also available on Apple Podcast: http://apple.co/30PvU9C

In this episode, we review the high-yield topic of Pelvic Inflammatory Disease (PID) from the Gynecology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets

All women should know about PID (Pelvic Inflammatory Disease) Share this episode with your sister, cousin, daughter, best friend!! Women's health is important!! Check it out! --- Send in a voice message: https://anchor.fm/urcaringdocs/message

The massive Winter storm could disrupt vaccine distribution across much of the country.Doctors are seeing more cases of an inflammatory syndrome in kids with COVID-19.Will Melbourne, Australia be successful with another strict lockdown?Will we ever escape the virus if billions of people around the world have to be vaccinated to achieve herd immunity?California and Florida had different approaches to the lockdown, so which was better?Rhode Island kept its schools open throughout the pandemic. How did it manage to do that? To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

This episode covers pelvic inflammatory disease!

It's not often one gets to talk to a brilliant scientist about college admissions and Paul Tough's book “The Years That Matter Most,” Ken Jennings vs. an artificial intelligence, an internship at Google vs. a Harvard undergraduate degree, Stanford University's wondrous document “Uncharted Territory,” and the incredible insights of excellent indigenous science. Even better is the fact that I caught all of this conversation on tape and can present it here in this podcast. Dr. Helen Turner is the VP for Strategy and Innovation at Chaminade University, a small, private college sitting on a lovely hillside above the city of Honolulu. Her resume is 14 pages long; she is a brilliant thinker and articulate spokesperson for things in K-12 and higher education we should all be excited about. (And in a couple cases, such as CRISPR being driven “underground,” very concerned about.) She has a strong bias towards action and innovation. Over a 90-minute interview, which will be released in two parts, Helen and I dug deep into what I called Ten Questions With Helen Turner. Yes, in couple cases we cheated by adding in bonus questions! This recording was done in a special dual-person soundproof phone booth at the Entrepreneurs Sandbox, managed by the one and only BoxJelly Co-Working team. So enjoy, and please give us a rating in your favorite podcast store! From Chaminade.edu we learn: “Dr. Turner is an internationally-regarded researcher in molecular immunology. As well as her position at Chaminade, she holds academic affiliations with the John A. Burns School of Medicine and Department of Microbiology at the University of Hawaii and serves on numerous scientific advisory boards. She collaborates with an extensive network of scientists nation-wide and has trained numerous graduate students for careers as biomedical investigators, science administrators and academics. Previous to her Chaminade appointment, she was an Associate Director of Research at The Queen's Center for Biomedical Research in Honolulu. Current projects in the Turner laboratory focus on mast cell ion channels as novel targets for therapeutic intervention in inflammatory pathologies, and on the molecular mechanisms by which cannabinoid compounds act as modulators of the immune system. Dr Turner's relatively young laboratory has been strikingly successful at winning grants from private foundations (The Leahi Fund for Pulmonary Research, The Victoria and Bradley Geist Foundation, The Culpeper Biomedical Pilot Initiative, and the Queen Emma Research Foundation), and from Federal sources (National Institute of General Medical Sciences, National Institute of Allergic and Inflammatory Disease, and the Idea Network for Biomedical Research Excellence). In addition to her efforts in seeking funding for her own program, Dr. Turner acts as an invited grant reviewer for the NIH, the British Welcome Trust, and several other funding bodies. Dr. Turner trained at the Imperial Cancer Research Fund Laboratories and received her Ph.D. from the University of London in 1998. Following a post-doctoral period at the Beth Israel Medical Center and Harvard Medical School, she assumed her position at Queens in 2000. While at Queens, Dr. Turner was head of a team of 10 scientists, whose efforts centered around the biology of mast cells. These immunocytes are central to inflammatory responses and are key players in pathologies such as asthma, eczema and multiple sclerosis.” For more on Dr. Turner's work, go to Chaminade's website.  The post 24. Ten Epic Questions for Helen Turner, Part 2 appeared first on @MLTSinHawaii .

 It's not often one gets to talk to a brilliant scientist about artificial intelligence, college admissions, David Epstein's book, “Range,” the scary questions of biology and the incredible insights of excellent indigenous science. Even better is the fact that I caught all of this conversation on tape and can present it here in this podcast. Dr. Helen Turner is the VP for Strategy and Innovation at Chaminade University, a small, private college sitting on a lovely hillside above the city of Honolulu. Her resume is 14 pages long; she is a brilliant thinker and articulate spokesperson for things in K-12 and higher education we should all be excited about. (And in a couple cases, such as CRISPR being driven “underground,” very concerned about.) She has a strong bias towards action and innovation. Over a 90-minute interview, which will be released in two parts, Helen and I dug deep into what I called Ten Questions With Helen Turner. Yes, in couple cases we cheated by adding in bonus questions! This recording was done in a special dual-person soundproof phone booth at the Entrepreneurs Sandbox, managed by the one and only BoxJelly Co-Working team. So enjoy, and please give us a rating in your favorite podcast store! From Chaminade.edu we learn: “Dr. Turner is an internationally-regarded researcher in molecular immunology. As well as her position at Chaminade, she holds academic affiliations with the John A. Burns School of Medicine and Department of Microbiology at the University of Hawaii and serves on numerous scientific advisory boards. She collaborates with an extensive network of scientists nation-wide and has trained numerous graduate students for careers as biomedical investigators, science administrators and academics. Previous to her Chaminade appointment, she was an Associate Director of Research at The Queen's Center for Biomedical Research in Honolulu. Current projects in the Turner laboratory focus on mast cell ion channels as novel targets for therapeutic intervention in inflammatory pathologies, and on the molecular mechanisms by which cannabinoid compounds act as modulators of the immune system. Dr Turner's relatively young laboratory has been strikingly successful at winning grants from private foundations (The Leahi Fund for Pulmonary Research, The Victoria and Bradley Geist Foundation, The Culpeper Biomedical Pilot Initiative, and the Queen Emma Research Foundation), and from Federal sources (National Institute of General Medical Sciences, National Institute of Allergic and Inflammatory Disease, and the Idea Network for Biomedical Research Excellence). In addition to her efforts in seeking funding for her own program, Dr. Turner acts as an invited grant reviewer for the NIH, the British Welcome Trust, and several other funding bodies. Dr. Turner trained at the Imperial Cancer Research Fund Laboratories and received her Ph.D. from the University of London in 1998. Following a post-doctoral period at the Beth Israel Medical Center and Harvard Medical School, she assumed her position at Queens in 2000. While at Queens, Dr. Turner was head of a team of 10 scientists, whose efforts centered around the biology of mast cells. These immunocytes are central to inflammatory responses and are key players in pathologies such as asthma, eczema and multiple sclerosis.” For more on Dr. Turner's work, go to Chaminade's website.  The post 23. Ten Epic Questions for Helen Turner, Part 1 appeared first on @MLTSinHawaii .

In this episode, it's all about gout! From our residents to yours, we go through a simple approach to gout including clinical presentation, diagnosis and treatment.