Podcasts about nanoscale

Literature Review 1) Microplastics in the Brain - From Science Advances: "Human health is being threatened by environmental microplastic (MP) pollution. MPs were detected in the bloodstream and multiple tissues of humans, disrupting the regular physiological processes of organs. Nanoscale plastics can breach the blood-brain barrier, leading to neurotoxic effects. How MPs cause brain functional irregularities remains unclear. This work uses high-depth imaging techniques to investigate the MPs within the brain in vivo. We show that circulating MPs are phagocytosed and lead these cells to obstruction in the capillaries of the brain cortex. These blockages as thrombus formation cause reduced blood flow and neurological abnormalities in mice. Our data reveal a mechanism by which MPs disrupt tissue function indirectly through regulation of cell obstruction and interference with local blood circulation, rather than direct tissue penetration. This revelation offers a lens through which to comprehend the toxicological implications of MPs that invade the bloodstream." (Huang et. al. 2025) This weeks podcast is a direct look at the world of toxicology and the human consequences of exposure over time. Microplastics are the new and next trouble maker on the planet. This study raises the concern that micro and nano plastics can and do enter the brain and will disrupt and thus alter brain physiological processes. More time to answer the true risk reality. Not good. and more....Plus a letter about MAHA from Dr. Jeffrey Bland, a serious take on preventative medicine as opposed to disease pharmaceutical centric medicine. Dr. M

In this episode, Anna and Guillermo speak with Professor Jelena Vučković from Stanford's Nanoscale and Quantum Photonics Lab about the fascinating world of quantum engineering. Jelena explains different quantum technology platforms and how quantum entanglement serves as the foundation for various applications such as eavesdropping detection. They explore how researchers are developing chip-scale quantum systems and the significant implications these technologies have for secure communication and cryptography. Related links: Episode 288: Quantum Cryptography with Or Sattath WHIR: Reed–Solomon Proximity Testing with Super-Fast Verification BB84: Quantum cryptography: Public key distribution and coin tossing BBM92: Quantum Cryptography Without Bell's Theorem Stanford Nanoscale Quantum Photonics Group Github Stanford Nanoscale and Quantum Photonics Lab Photonics: Practical & Optimized: A Talk by Jelena Accelerator that fits on a chip work by Jelena Spots for zkSummit13 are limited - grab your ticket at www.zksummit.com Missing Link are a talent team built for the Web3 era, helping projects across the ecosystem connect with the right candidates at the right time. Whether you're an established project or a startup searching for specialized talent, Missing Link can help. Visit their website at missing-link.io. **If you like what we do:** * Find all our links here! @ZeroKnowledge | Linktree * Subscribe to our podcast newsletter * Follow us on Twitter @zeroknowledgefm * Join us on Telegram * Catch us on YouTube

Tim Tobin, CEO and Founder of Planatome, has a background in the semiconductor industry where precision polishing techniques were developed. Planatome has used that technology to create molecularly smooth scalpel blades that remove all the jagged edges on traditional surgical scalpels. These new nano polished blades significantly reduce scarring and inflammation from incisions and improve healing outcomes for patients, especially those with darker skin tones who are more prone to hypertrophic scarring. The challenge is disrupting an industry that has not changed in over 100 years and that has been driven by reducing the costs, not improving the blade. Tim explains, "So we picked the surgical scalpel because it's still the foundation, the primary incision tool, whether it's a minimally invasive procedure or a procedure with a lot of cutting. So we started with that. We've since applied our technology to many other surgical instruments. We started with the scalpel, which was patented in 1915. There's been no change, no technological change, just change to drag down the cost. So it's just completely commoditized, a scalpel blade somewhere in the 20 to 50 cent range, and nobody thinks about it because everybody just uses a scalpel, and they don't need to be more critical."  "So we started looking, and if you look at a scalpel blade underneath magnification, it looks almost like it's highly serrated and jagged because they're made by taking a piece of stainless steel, and they grind it up to a point, and that's the cutting edge. But they leave it like that." "We took that, and we said, okay, well, what if we polish it and take out all of those jagged serrations, at least a thousand times smoother. Now if you measure the surface, it changes the cutting mechanism from tearing and snagging to a nice clean incision. So some of the challenges in that is when surgeons have been using the same thing pretty much their whole career, when they try something different, that's not always something they want to think about."  #Planatome #MedTech #MedicalDevice #Surgery planatome.com Download the transcript here

Tim Tobin, CEO and Founder of Planatome, has a background in the semiconductor industry where precision polishing techniques were developed. Planatome has used that technology to create molecularly smooth scalpel blades that remove all the jagged edges on traditional surgical scalpels. These new nano polished blades significantly reduce scarring and inflammation from incisions and improve healing outcomes for patients, especially those with darker skin tones who are more prone to hypertrophic scarring. The challenge is disrupting an industry that has not changed in over 100 years and that has been driven by reducing the costs, not improving the blade. Tim explains, "So we picked the surgical scalpel because it's still the foundation, the primary incision tool, whether it's a minimally invasive procedure or a procedure with a lot of cutting. So we started with that. We've since applied our technology to many other surgical instruments. We started with the scalpel, which was patented in 1915. There's been no change, no technological change, just change to drag down the cost. So it's just completely commoditized, a scalpel blade somewhere in the 20 to 50 cent range, and nobody thinks about it because everybody just uses a scalpel, and they don't need to be more critical."  "So we started looking, and if you look at a scalpel blade underneath magnification, it looks almost like it's highly serrated and jagged because they're made by taking a piece of stainless steel, and they grind it up to a point, and that's the cutting edge. But they leave it like that." "We took that, and we said, okay, well, what if we polish it and take out all of those jagged serrations, at least a thousand times smoother. Now if you measure the surface, it changes the cutting mechanism from tearing and snagging to a nice clean incision. So some of the challenges in that is when surgeons have been using the same thing pretty much their whole career, when they try something different, that's not always something they want to think about."  #Planatome #MedTech #MedicalDevice #Surgery planatome.com Listen to the podcast here

In today's episode, Robert and Francis look into the shortcomings of 5G and the future of nanoscale data centers.

A nanoparticle is a tiny particle typically in the size range of one to one hundred nanometres. Nano-scale systems can exhibit unique quantum mechanical properties due to their size.  The European Association for Cooperation in Science and Technology, which recently celebrated its second anniversary, focuses on the science of confined molecular systems. In this episode, we hear about their works to uncover the properties and behaviours of metal nanoparticles and clusters. Visit their site: https://cost-cosy.eu/Read the original research:https://doi.org/10.1002/sstr.202400147https://dx.doi.org/10.1002/chem.202301517 https://pubs.rsc.org/en/content/articlelanding/2023/cp/d2cp05843jhttps://pubs.acs.org/doi/full/10.1021/acscatal.3c02592https://www.sciencedirect.com/science/article/pii/S0021951723000842https://dx.doi.org/10.1021/acs.jpclett.2c03923

Robert and Francis talk about the future of technology and the role that nanoscale data will play.

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In this month's Fertility and Sterility: Unplugged, we take a look at articles from F&S's sister journals! Topics this month include a review of studies of menstrual fluid (2:18), changing our language regarding progestin protocols (18:35), and nanoscale motion tracing of spermatozoa (26:46). F&S Reviews: https://www.fertstertreviews.org/article/S2666-5719(24)00032-X/fulltext Consider This: https://www.fertstert.org/news-do/language-matters-rename-progestin-priming-progestin-protocols-vitro-fertilization-ivf F&S Science: https://www.fertstertscience.org/article/S2666-335X(24)00037-5/fulltext View the sister journals at: https://www.fertstertreviews.org https://www.fertstertreports.org https://www.fertstertscience.org  

Check out the next episode of our podcast, Under the Surface! In episode 6, Revolutionizing Nanoscale Visualization, we talk to Nanome CEO and co-founder Steve McCloskey. In a virtual rollercoaster of a conversation, he shares Nanome's scrappy beginnings, the challenge and excitement of bringing new ways of interacting with models to the science community, and paints a vivid picture of an exciting element of the future of molecular modeling.  It's Reality Jim, but not as we know it… Interested in giving this a test drive?  Contact hello@nanome.ai to set up a demo with Nanome.

In this conversation, Pranoti Kshirsagar interviews T N Narayanan, a group leader at the Tata Institute of Fundamental Research in Hyderabad. They discuss the field of materials and interface engineering, which focuses on understanding and controlling interfaces between different materials. T N Narayanan explains the importance of studying interfaces in various applications, such as transistors and electrochemical reactions. He also shares his career journey, including his work on magnetic nanoneedles and the development of nanotube sponges for oil absorption and water purification. In this conversation, T N Narayanan discusses his career journey and research in the field of interface and materials engineering. He talks about his work on doped graphene and boron nitride for catalytic applications, as well as his research on water splitting for hydrogen production. He emphasizes the importance of understanding the role of interfaces in various electrochemical processes. T N Narayanan also shares his passion for international collaborations and learning from different fields. He expresses his desire for more training and exposure to different research cultures. In the second part of the conversation, T N Narayanan discusses his upcoming takeover of the RealScientistNano Twitter account, where he plans to introduce himself, showcase his lab's research, and share research news. Takeaways Materials and interface engineering focuses on understanding and controlling interfaces between different materials. Studying interfaces is important for various applications, such as transistors and electrochemical reactions. T N Narayanan's research includes the development of nanotube sponges for oil absorption and coated sand for water purification. His career journey includes work on magnetic nanoneedles and the founding of a company. T N Narayanan's research focuses on interface and materials engineering, with a particular interest in electrochemical processes and catalytic applications. He has worked on doped graphene and boron nitride as efficient catalysts for various reactions, and he has also studied water splitting for hydrogen production. Understanding the role of interfaces is crucial in improving the efficiency of electrochemical processes and developing sustainable energy solutions. T N Narayanan emphasizes the importance of international collaborations and learning from different fields to advance scientific knowledge. He expresses his desire for more training and exposure to different research cultures to further enhance his understanding of complex scientific problems. T N Narayanan will be taking over the RealScientistNano Twitter account to introduce himself, showcase his lab's research, and share research news. Chapters 00:00 Introduction 01:34 Research on Materials and Interface Engineering 05:35 Applications in Transistors and Catalysis 07:58 Implications in Electronics 13:39 Wide Range of Applications 14:32 Career Journey 21:17 Starting a Company 22:44 Water Purification 24:11 Research on Removing Heavy Metal Ions 24:50 Move to TIFR and Electrochemical Research 26:16 Research on Nanomaterials for Catalytic Applications 28:51 Continued Interest in Understanding Interfaces 31:25 Research on Water Splitting and Interface Structure 36:09 Role of Interface in Hydrogen Generation 39:32 Benefits of Being a Scientist 41:18 Challenges and Wishes for Research Experience 45:04 Upcoming International Research Experience 46:13 Takeover of Real Scientist Nano Twitter Account 48:39 Available-podcast_YT.mp4 --- Send in a voice message: https://podcasters.spotify.com/pod/show/under-microscope/message

In this episode, host Pranoti Kshirsagar interviews scientist T N Narayanan about his research in materials and interface engineering. They discuss the applications of his work in transistors, catalysis, electronics, and water purification. Narayanan shares his career journey, including his work on nanotube sponges and starting a company. Overall, his research aims to understand and engineer interfaces to solve various problems and improve the efficiency of devices and reactions. In this conversation, T N Narayanan discusses his research journey and interests in the field of materials and interfaces. He shares his work on removing heavy metal ions using sand, research on nanomaterials for catalytic applications, and the role of interfaces in hydrogen generation. He also highlights the benefits of being a scientist, the challenges faced in research, and his wishes for improving the research experience. Additionally, he mentions his upcoming international research experience and his takeover of the Real Scientist Nano Twitter account. Takeaways Materials and interface engineering focuses on understanding and engineering interfaces between different materials. Research in this field has applications in transistors, catalysis, electronics, and water purification. Efficient metal-semiconductor interfaces are crucial for improving the performance of electronic devices. Nanotube sponges have potential applications in oil spill cleanup and water purification --- Send in a voice message: https://podcasters.spotify.com/pod/show/under-microscope/message

In this week's episode of Future Creators, Robert and Francis dive into who survived the coming nanoscale data revolution.

This week, Robert and Francis dive into nanoscale data centers.

Hydration matters: The interaction patterns of water and oxide crystals revealedTranscript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Keisuke Miyazawa at the Kanazawa University NanoLSI.The research described in this podcast was published in Nanoscale in July 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Hydration matters: The interaction patterns of water and oxide crystals revealed.https://nanolsi.kanazawa-u.ac.jp/en/highlights/28428/ In a study recently published in the journal Nanoscale, researchers from Kanazawa University and AGC Inc. use three-dimensional atomic force microscopy to study the hydrated form and structure of commonly occurring oxide crystals. While sapphire and quartz are oxide crystals used in a wide range of industrial applications, the atomic-scale structures of these materials are not well understood. The major chemical components of sapphire and quartz are aluminum oxide and silicon dioxide, respectively. These components have a high affinity for water, which affects the chemical reactivity of the crystals. Thus, a thorough knowledge of the water-binding properties of these oxides is important for further innovative applications. To date, traditional microscopic methods have only provided insights into the two-dimensional topography of their surfaces. Now, a research team led by Keisuke Miyazawa from the NanoLSI at Kanazawa University has developed three-dimensional (3D) microscopy technique for a detailed study of the interaction of the surfaces of these materials with water.So how did they do it?The team started by looking at the surface structures and its hydration structures of sapphire and α-quartz in water. For this, they used an advanced form of microscopy known as 3D atomic force microscopy (3D-AFM). Oxide crystals usually have hydroxyl (OH) groups, which are the main “water-binding” molecules, closely linked with the oxides. Hence, the team studied the OH groups and its hydration structures on both crystals when immersed in water. They found that the hydration layer on sapphire was not uniform because of the nonuniform local distributions of the surface OH groups. On the other hand, the hydration layer on α-quartz was uniform because of the atomically flat distributions of the surface OH groups. When the interaction force of these oxides with water was subsequently measured, it was found that a greater force was required to break the water-crystal bonds in sapphire than in α-quartz. Lastly, it was also discovered that this affinity was much higher in regions where the oxides were in close proximity to the OH groups. This study showed that the hydration structures of oxides are dependent on the location and density of OH groups, in addition to the strength of the OH groups' hydrogen bonding (the chemical bond used to bind to water). What's more, it was successfully shown here that 3D-AFM can be used in unraveling the interaction of water with several surfaces, a potential avenue for understanding solid-liquid interactions better. “This study contributes to the application of 3D-AFM in exploring atomic scale hydration structures on various surfaces, and hence, to a wide range of solid–liquid interfacial research fields,” conclude the researchers.   ReferenceSho Nagai, Shingo Urata, Kent Suga, Takeshi Fukuma, Yasuo Hayashi and Keisuke Miyazawa. Three-dimensional ordering of water molecules reflecting hydroxyl groups on sapphire (001) and α-quartz (100) surfaces   NanoLSI Podcast website

Endoscopy of a living cell on the nanoscale Transcript of this podcast Hello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Takeshi Fukuma at the Kanazawa University NanoLSI. The research described in this podcast was published in Science Advances in December 2021 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Endoscopy of a living cell on the nanoscaleResearchers at Kanazawa University report in Science Advances a new technique for visualizing the inside of a biological cell. The method is an extension of atomic force microscopy and offers the promise of studying nanoscale inner cell dynamics at high resolution in a non-destructive way.In order to advance our understanding of how biological cells function, visualizing the dynamics of intra-cellular components on the nanoscale is of key importance.  Current techniques for imaging such dynamics are not optimal — for example, fluorescence microscopy can visualize ‘labeled' molecules but not the target components themselves.  Now Takeshi Fukuma from Kanazawa University and his colleagues have developed a label-free, non-destructive nanoimaging method, which they call nanoendoscopy-AFM – it's a version of atomic-force microscopy that can be deployed within a living cell.  The research was carried out as a collaboration between Kanazawa University and the National Institute of Advanced Industrial Science and Technology (AIST), with Marcos Penedo, the lead author of the publication reporting the new method, recently moving from Kanazawa University's Nano Life Science Institute (WPI-NanoLSI) to the École Polytechnique Fédérale de Lausanne, Switzerland.So what is AFM in the first place?The principle of AFM – or atomic force microscopy ti give its full title - is to have a very small tip move over the surface of a sample.  During this ‘xy' scanning motion, the tip, attached to a small cantilever, will follow the sample's height, that is, the (‘z') dimension or profile, producing a measurable force on the cantilever.  The magnitude of the force can be back-converted into a height value; the resulting height map provides structural information about the sample's surface.The researchers designed a novel AFM setup where the needle-like tip is brought in and out of the interior of a cell.  The process is reminiscent of an endoscopy — the procedure of looking at an organ from the inside, by inserting a small camera attached to a thin tube into the body — which is why Fukuma and colleagues call their technique nanoendoscopy-AFM.  Letting the nanoneedle travel in an ‘xyz' trajectory, and going in and out of the cell results in a 3D map of its structure.  They tested the technique on a cell from the so-called HeLa cell line commonly used in medical research, and could clearly identify internal granular structures in a scanned volume of 10 x 10 x 6 µm3.But how does the cell fare under this kind of interrogation?During a scan, the nanoneedle penetrates the cell membrane (and the nuclear membrane) many times.  The scientists checked whether this repeated penetration causes any damage to the cell.  They performed a viability test on HeLa cells by using two fluorescent marker molecules.  One molecule emits green fluorescence from a living cell, the other red fluorescence from (the nucleus of) a dead cell.  The researchers found that when using nanoprobes smaller than 200 nm, nanoendoscopy-AFM does not severely damage cells.The method is also particularly useful for probing surfaces within the cell, for example the inner side of the cell membrane or the surface of the cell nucleus.  Fukuma and colleagues call this application 2D NanoLSI Podcast website

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.31.551204v1?rss=1 Authors: Chen, J. K., Liu, T., Cai, S., Ruan, W., Ng, C. T., Shi, J., Surana, U., Gan, L. Abstract: The structure of chromatin at the nucleosome level inside cells is mysterious. Here we present in situ cryo-ET analyses of chromatin in both G1 and metaphase RPE-1 cells. G1 nucleosomes are concentrated in globular chromatin domains and metaphase nucleosomes are concentrated in the chromatids. Classification analysis reveals that canonical mononucleosomes, ordered stacked dinucleosomes, and mononucleosomes with a disordered gyre-proximal density are abundant in both cell-cycle states. Class averages that have more than two stacked nucleosomes or that have side-by-side dinucleosomes are not detected, suggesting that groups of more than two nucleosomes are heterogeneous. Large multi-megadalton structures are abundant in G1 nucleoplasm, but not found in G1 chromatin domains and metaphase chromatin. The macromolecular phenotypes studied here represent a starting point for the comparative analysis of condensation in normal and unhealthy human cells, in other cell-cycle states, other organisms, and in vitro chromatin assemblies. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Innovation technologique Liliane Bettencourt (2022-2023) - Lydéric BocquetCollège de FranceAnnée 2022-2023Colloque - La nanofluidique à la croisée des chemins : Condensed Matter at NanoscaleScanning Probe Microscopy is a powerful tool for the investigation of the properties of confined systems. In this presentation we will discuss how soft and hard condensed matter undergo to a dramatic phase change when confined at the nanoscale and we will investigate the complex coupling between fluids and bidimensional materials.Alessandro SiriaAlessandro Siria is a CNRS researcher and Professor at École normale supérieure. His research interests are at the interface between soft matter and nano science. Awarded with 2 European Research Council grants, he is co-founder of 4 start-up companies aiming at the industrialisation of novel nanofluidics functionaries.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.15.528622v1?rss=1 Authors: Kumari, R., Ven, K., Chastney, M., Peranen, J., Arron, J., Almeida-Souza, L., Kremneva, E., Poincloux, R., Chew, T. L., Gunning, P. W., Ivaska, J., Lappalainen, P. Abstract: Focal adhesions (FAs) connect inner workings of the cell to the extracellular matrix to control cell adhesion, migration, and mechanosensing. Previous studies demonstrated that FAs contain three vertical layers, which connect extracellular matrix to the cytoskeleton. However, cellular processes rely on precisely-regulated FA turnover, but the molecular machineries that control FA assembly and disassembly have remained elusive. By using super-resolution iPALM microscopy, we identified two unprecedented nanoscale layers within FAs, specified by actin filaments bound to tropomyosin isoforms Tpm1.6 and Tpm3.2. The Tpm1.6-actin filaments beneath the previously identified actin-regulatory layer are critical for adhesion maturation and controlled cell motility, whereas the Tpm3.2-actin filament layer towards the bottom of FA facilitates adhesion disassembly. Mechanistically, Tpm3.2 stabilizes KANK-family proteins at adhesions, and hence targets microtubule plus-ends to FAs to catalyse their disassembly. Loss of Tpm3.2 leads to disorganized microtubule network, abnormally stable FAs, and defects in tail retraction during cell migration. Thus, FAs are composed of at least three distinct actin filament layers, each having specific roles in coupling of adhesion to the cytoskeleton, or in controlling adhesion dynamics. In a broader context, these findings demonstrate how distinct actin filament populations can co-exist and perform specific functions within a defined cellular compartment. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Invisibility cloaks have long been featured in science fiction, but where are we when it comes to science fact? We look at the science behind bending light in interesting ways, and learn how metamaterials could play a part in making something invisible.See omnystudio.com/listener for privacy information.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.26.525608v1?rss=1 Authors: Fuentes, L. A., Marin, Z., Tyson, J., Baddeley, D., Bewersdorf, J. Abstract: The endoplasmic reticulums (ER) structure is directly linked to the many functions of the ER but its formation is not fully understood. We investigate how the ER-membrane curving protein reticulon 4 (Rtn4) localizes to and organizes in the membrane and how that affects local ER structure. We show a strong correlation between the local Rtn4 density and the local ER membrane curvature. Our data further reveal that the typical ER tubule possesses an elliptical cross-section with Rtn4 enriched at either end of the major axis. Rtn4 oligomers are linear-shaped, contain about five copies of the protein, and preferentially orient parallel to the tubule axis. Our observations support a mechanism in which oligomerization leads to an increase of the local Rtn4 concentration with each molecule increasing membrane curvature through a hairpin wedging mechanism. This quantitative analysis of Rtn4 and its effects on the ER membrane result in a new model of tubule shape as it relates to Rtn4. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Full episode featuring Andy is a very unique as this is the first time we have a scientist working at the interface of two giant fields - nanoscience & artificial intelligence. Our guest Andy of the University of Copenhagen (Denmark) talks about his research, science career, walks, and much more! Find out more at thesciencetalk.com/real-scientists-nano/curators/#curators22

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.21.521505v1?rss=1 Authors: He, K., Han, Y., Li, X., Hernandez, R. X., Riboul, D. V., Feghhi, T., Justs, K. A., Mahneva, O., Perry, S., Macleod, G. T., Dickman, D. Abstract: Neurons exhibit a striking degree of functional diversity, each one tuned to the needs of the circuitry in which it is embedded. A fundamental functional dichotomy occurs in activity patterns, with some neurons firing at a relatively constant tonic rate, while others fire in bursts - a phasic pattern. Synapses formed by tonic vs phasic neurons are also functionally differentiated, yet the bases of their distinctive properties remain enigmatic. A major challenge towards illuminating the synaptic differences between tonic and phasic neurons is the difficulty in isolating their physiological properties. At the Drosophila neuromuscular junction (NMJ), most muscle fibers are co-innervated by two motor neurons, the tonic MN-Ib and phasic MN-Is. Here, we employed selective expression of a newly developed botulinum neurotoxin (BoNT-C) transgene to silence tonic or phasic motor neurons. This approach revealed major differences in their neurotransmitter release properties, including probability, short-term plasticity, and vesicle pools. Furthermore, calcium imaging demonstrated ~two-fold greater calcium influx at phasic neuron release sites relative to tonic, along with enhanced synaptic vesicle coupling. Finally, confocal and super resolution imaging revealed that phasic neuron release sites are organized in a more compact arrangement, with enhanced stoichiometry of voltage-gated calcium channels relative to other active zone scaffolds. These data suggest that distinctions in active zone nano-architecture and calcium influx collaborate to differentially tune glutamate release at synapses of tonic vs phasic neuronal subtypes. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Clip: Mark Hersam "Hybrid Hard And Soft Nanoscale Materials, Neuromorphic Computing" by Marwa ElDiwiny

Mark Hersam "Hybrid Hard And Soft Nanoscale Materials, Neuromorphic Computing" by Marwa ElDiwiny

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.22.517517v1?rss=1 Authors: Smyrlaki, I., Fördös, F., Rocamonde Lago, I., Wang, Y., Lentini, A., Luca, V. C., Reinius, B., Teixeira, A. I., Högberg, B. Abstract: The Notch signaling pathway is a cell-cell communication system with fundamental roles in embryonic development and the nervous system. The model of Notch receptor activation that is currently most accepted, involves a force-induced conformation change at the negative regulatory region of the receptor, the subsequent recruitment of ADAM metalloproteases and a cleavage cascade that releases the Notch intracellular domain. Here, we define conditions that enable force-independent Notch activation through the formation of soluble, long-lived, multivalent ligand-receptor complexes. To investigate how ligand valency affects activation of Notch receptors, we treated iPSc-derived neuroepithelial stem-like (lt-NES) cells with different spatially defined, molecularly precise ligand nanopatterns on DNA origami nanostructures. Our data indicate that Notch signaling is activated via stimulation with multivalent clusters of the ligand Jag1, and even multivalent chimeric structures where some Jag1 proteins are replaced by other binders that do not target Notch. The findings are corroborated by systematic elimination, through experimental control, of several confounding factors that potentially could generate forces, including electrostatic interactions, endocytosis and non-specific binding. Taken together, our data suggest a model where Jag1 ligands are able to activate Notch receptors upon prolonged binding, which subsequently triggers downstream signaling in a force independent manner. These findings reveal a distinct mode of activation of Notch and could lay the foundation for the development of soluble Notch agonists that currently remain elusive. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

"Polytherapeutic" tinnitus treatment app delivers impressive results | New Atlas (00:49) Tinnitus is when you experience ringing or other noises in one or both of your ears.  5% of people experience tinnitus at some point in their lives A team of researchers at the University of Auckland has found it's new smartphone app treatment is getting strong results This polytherapeutic “combines goal-based counseling with personalized passive and active game-based sound therapy."  It has tailored the digital tools in the app to the user's own experience of tinnitus. The primary measurement of effectiveness was the Tinnitus Functional Index, a standard scale used to quantify a person's experience of tinnitus A 13 point change is regarded as a clinically meaningful difference. It is a survey so take this with a grain of salt The group using the polytherapeutic reported an average improvement of 16.36 points after six weeks, and 17.83 points after 12 weeks 55% of participants experiencing a clinically meaningful improvement after six weeks 65% at 12 weeks. The Auckland team is working on obtaining regulatory approval for the polytherapeutic app, and hope to have it clinically available within six months or so. Rare Elephant Twins are Born in 'Historic Moment' at Syracuse Zoo | Today (05:54) Twin Asian elephant calves were born at the Rosamond Gifford Zoo in Syracuse, New York, in what the zoo is calling a “miracle.” Born on Oct. 24 Ten hours after Mali's (Mama Elephant obviously) first male calf was born, weighing in at 220 pounds, a second male calf arrived, weighing 237 pounds.  The zoo commented on this improbability and rarity: “To date, there has never been a recorded case of surviving elephant twins in the United States …  The few successful twin births have only taken place in their range countries in Asia and Africa and nowhere else in the world.” Additionally, less than 1% of elephant births worldwide are twins When twins do occur, the calves are often stillborn or do not survive long after birth. Engineers designed a new nanoscale 3D printing material that can be printed at a speed of 100 mm/s | Interesting Engineering (09:43) A new nanoscale 3D printing material developed by Stanford University engineers may provide superior structural protection for satellites, drones, and microelectronics An improved lightweight, a protective lattice that can absorb twice as much energy as previous materials of a similar density Nanoscale 3D printing material creates structures that are a fraction of the width of a human hair. Enabling the printing at very small scales. The engineers added metal nanoclusters (tiny groupings of atoms) to their printing medium to create a superior 3D printing material. Effective in kicking off the reaction to harden the material  Produced a substance that was a mixture of the metal and the polymer printing medium. The printing process was accelerated by the nanoclusters. They were able to print at a speed of 100 millimeters per second using the nanoclusters and proteins. Roughly 100 times faster than what had previously been possible with nanoscale protein printing. The engineers are in some ways imitating what nature has already mastered. For instance, the mix of a hard exterior, nanoscale porosity, and trace amounts of soft substance gives bone its durability. Where to go from here? Wendy Gu, an assistant professor of mechanical engineering and a corresponding author on the paper stated: “Since the nanoclusters are able to polymerize these different classes of chemicals, we may be able to use them to print multiple materials in one structure … That's one thing we'd like to aim for.” Researchers develop a new method for analyzing rock glaciers | Phys.org (15:20) Scientists at the University of Arizona developed a new method to determine rock glaciers' ice thickness and the ratio of ice to debris, allowing for more precise measurements of these glaciers than previously possible.  Lead by Tyler Meng who is pursuing a doctoral degree in planetary science This new method will allow scientists to better understand water resources on both Earth and Mars, as well as how resilient this type of buried ice will be to the changing climate on both planets. Both pure ice glaciers and rock glaciers can move across landscapes—very slowly.  The debris in rock glaciers causes them to flow even more slowly than ice glaciers, as the inclusion of rocks makes them much stiffer. Using two different antenna configurations, the researchers used ground-penetrating radar to measure both the radar wave speed and the angle at which the wave was reflected from the subsurface.  The two antenna configurations allowed the researchers to better calculate the dimensions of the rock glacier. According to Meng, understanding rock glaciers on Earth is important because they are essentially water reservoirs. To continue: “Our research gives us a better idea of the total water budget in mountainous regions, where major rivers have headwaters … By having a map of the debris thickness and ice concentration, we can essentially characterize the ability of rock glaciers to withstand effects of a warming climate compared to clean ice glaciers" The whole goal of the research is to use Earth rock glaciers as an analog to processing them on Mars. Meng stated: "By mapping the patterns of debris thickness on Earth, we're trying to understand how that debris thickness may also vary on Mars. Also, by learning about the differences in flow parameters between clean ice and debris-rich ice, that will help simulations for the Martian case as well." Moving forward, the research group will continue to make similar measurements using surface-based radar while also collecting new data using drones.  Drone-based data collection will help the group to gain a more complete understanding of rock glacier flow and subsurface characteristics A Lab-Grown Meat Startup Gets the FDA's Stamp of Approval | MIT Tech Review (20:00) A company called Upside Foods will soon be able to sell chicken made from real animal cells grown in bioreactors instead of requiring the slaughter of live animals.   Cultivated meat has been greenlit in the United States for the first time. There are just two smaller regulatory steps remaining until cultivated meat can be made available to the public.  Require a grant of inspection from the United States Department of Agriculture (USDA)  The food itself will need a mark of inspection before it can enter the US market Different startups are focusing on a range of cultivated meats, including: beef, chicken, salmon, and tuna It's likely that tasting these meats will be limited to a very small number of exclusive restaurants. With the CEO Uma Valeti wanting chefs to initially bring this to people's attention with well made meals. In December 2020, Singaporean regulators gave the green light to cultivated chicken from the San Francisco–based startup Eat Just.  The chicken nuggets were sold at a members-only restaurant called 1880 and later made available for delivery. Cultivated meat is different from plant-based meats because it contains real animal cells and is—theoretically—indistinguishable from real meat itself. The process: Cell line: a single cell is stimulated to allow it to expand into multiple cells Cells are initially isolated from an animal and developed into cell lines that are then frozen.  Small samples from these cell lines can then be transferred to bioreactors Bioreactors are where cells are fed growth media containing the nutrients that cells need to divide. Once grown, the cells are differentiated into the correct kind of tissue where they can be harvested and used in cultivated meat products. Startups keep the exact cost of growing their cells tightly under wraps, but it's likely that pure cultivated meat will still be several times the cost of conventional meat. But this has dropped considerably from when this method was first used. In August 2013, Dr Mark Post from the Netherlands created the world's first hamburger made from the stem cells of a cow for $325,000 USD at a taste testing and cooking demonstration in London, United Kingdom. Some projections for future facilities suggest that even large facilities will produce meat at a cost of $17 per pound. Translation: higher prices in restaurants and grocery stores. Current production facilities are very small, and many in the industry have serious reservations about lab-grown meat's ability to eventually put a dent in global meat consumption.   

Episode Summary: DNA is an ideal molecule for storing information in our genomes because it's stable, programmable, and well understood. The same qualities make DNA a great building block or construction material for nanoscale biomolecular structures that have nothing to do with our genome, like molecular scaffolds created by folding DNA into 2D and 3D shapes. This technology is known as DNA origami.However, the practical applications of DNA origami are limited by spontaneous growth and poor reaction yields. Anastasia developed a method that uses crisscross DNA polymerization of single-stranded DNA slats or DNA origami tiles to assemble DNA structures in a seed-dependent manner. This work may be useful to produce ultrasensitive, next-generation diagnostics or in programmable biofabrication at the multi-micron scale.Search Keywords: fifty years, bio, translation, ayush noori, ashton trotman grant, dna origami, dna, monomers, anastasia ershova, structures, diagnostics, proteins, micron scale, nucleation, biology, nanoscaleEpisode Notes:About the Guest Anastasia is a PhD candidate at Harvard University, currently working on DNA nanotechnology in William Shih's lab at the Wyss Institute and Dana-Farber Cancer Institute.She received her bachelor's degree in Natural Sciences from Cambridge University.During her PhD at Harvard, she co-founded the Molecular Programming Interest Group, an international community of students in the molecular programming, DNA computing and related fields.Impact DNA Origami will provide us with a plethora of new information on biology and physics.By manipulating that data on the nanoscale, we can get answers to a lot of questions in the future.Quick diagnostics can enable people all over the world to quickly get diagnosis-related answers and seek targeted treatment.PapersRobust nucleation control via crisscross polymerization of highly coordinated DNA slatsMulti-micron crisscross structures from combinatorially assembled DNA-origami slats

The week's very special real nano scientist is our own Sara H. Mejias. Sara is not only a researcher at IMDEA Nanoscience in Madrid, Spain, but also recently joined the team behind Real Scientists Nano. In this episode she talks about her interdisciplinary research spanning molecular biology and laser spectroscopy. Find out more at thesciencetalk.com/real-scientists-nano/curators/#curators22

CRUISERS! We are off to the the University of South Carolina where they are into the fine fine arts. We are talking nanoscale arts. This team of researchers has mastered a technique to create the smallest 3D printed materials ever and used them to print super delicate structures like tiger lilies! There is so much to unpack in this episode. Enjoy! --- Support this podcast: https://podcasters.spotify.com/pod/show/cruisinonthecuttingedge/support

Researchers are always working to develop faster and more powerful computers.  Some of them believe that the future of computing lies with neuromorphic computers, which are systems designed to mimic the neurons and synapses found in the human brain. The human brain has more than 100 billion neurons with more than 1 quadrillion synapses or […]

Sam and Thomas discuss the One World Government Agenda, Tax Free Foundations, President Biden escalating the Russia/Ukraine Conflict, European MP that called out Trudeau for the tyrant that he is, Yuval Noah Harari is advisor to Klaus Schwab - of the World Economic Forum - WEF -, Nanoscale robotic units can be aerosolized and weaponized to be absorbed by the vascular system without the victim even being aware of its happening, COVID-19 vaccine adverse reactions and much more… Broadcasting in the California Central Valley Here: Comcast Xfinity Ch. 93, AT&T U-Verse Ch. 99 Cablecast app on Roku or Apple TV https://cmac.tv/apps/ https://cmac.tv/series/weaponized-news/ Share and Follow and Subscribe to: Alpha Omega Energy https://twitter.com/AOEBreakthrough aomegaenergy.com +855 818 55 800 (Also Whatsapp) Telegram: AlphaOmegaEnergy Share and Follow and Subscribe to Weaponized News https://anchor.fm/weaponizednews https://www.brighteon.com/channels/weaponizednews https://odysee.com/@WeaponizedNews:6 https://www.bitchute.com/channel/t8y7ptaYWaFl/ https://gab.com/WeaponizedNews https://twitter.com/WeaponizedNews Help the Weaponized News Pay Some Bills Donate https://www.paypal.com/donate?token=SMJThaUrGts7xg3e2v_QRwXmPibJym12pzJPcjpi9xwKo1HAm0WlcJUal43SKOErssQYynjCc6t8DGoC Bitcoin 36fNy89D8vnmH2Ty14ceeoaoomHzGvsH8o

Hear from researchers at the University of Sydney Nano Institute (Sydney Nano), who are working at the cutting-edge of nanoscience. Professor Zdenka Kuncic shares how the research team is delivering cures for neurological diseases by rethinking interventions in the nervous system. Dr Shelley Wickham is working on a project building autonomous, programmable robots that can detect disease early for treatment and prevention. Professor Chiara Neto talks about developing a low-cost method to capture water in the air, to tackle the impacts of drought. Associate Professor, chemist and science communicator Alice Motion is our host, with opening remarks from Sydney Nano Director, Professor Benjamin Eggleton. This recording was from a live event on 25 November, 2021. For links to further resources, including the transcript, visit the Sydney Ideas website: https://bit.ly/3li5Zk7

In this episode of the “Stories from the NNI” podcast, Heather Clark, Professor of Bioengineering and Chemistry at Northeastern University, discusses her work on developing biosensors to measure, at the nanoscale, how biochemicals are regulated in the body. If you would like to learn more about nanotechnology, go to nano.gov or email us at info@nnco.nano.gov. Closed captioning is provided on our YouTube channel. For this episode, go to: https://youtu.be/mcqWDtcJvUw CREDITS Special thanks to:  Heather ClarkNortheastern University Produced by:Andrew Pomeroy Music:  Inspirational Outlook by Scott Holmes  https://freemusicarchive.org/music/Sc...https://creativecommons.org/licenses/... Any opinions, findings, conclusions, or recommendations expressed in this podcast are those of the guest and do not necessarily reflect the views of the National Nanotechnology Coordination Office or United States Government. Additionally, mention of trade names or commercial products does not constitute endorsement or recommendation by any of the aforementioned parties. Any mention of commercial products, processes, or services cannot be construed as an endorsement or recommendation.

Here today to unpack how immersive interfaces support drug research and development is Keita Funakawa, founder and COO of Nanome. Join us to hear about the first application that Nanome set out to mainstream; drug discovery, and how they are bringing their vision to bring science into a collaborative, intuitive, and obvious space. You'll also learn about Harvard's study into how VR can support chemistry education, and what it has been like for Keita to work with big pharmaceutical companies with a product he built right out of school. We touch on quantum computing, and discuss the COVID19 supercomputing project Nanome has been involved with, before talking about the AI generated potential therapeutics analyzed by humans in virtual reality. Nanome reaches far and wide, from being used to analyze battery cells, to integrations in the food and beverage industry. Keita shares a bit about these relationships, and reveals the details of his funding journey during the pandemic. We hope you join us to hear all this and more today!  Key Points From This Episode:The first application that Nanome set out to mainstream: drug discovery.An introduction to our guest, Keita Funakawa.Nanome's vision for what science ought to look like: collaborative, intuitive, and obvious.How education forms part of the vision to lower the barrier to entry to complex data. Harvard's study into how VR can support chemistry education.What it has been like working with big pharmaceutical companies with a product they built just out of school.Nanome's role in enabling scientists to make mistakes early and virtually.How they are starting to integrate with quantum computers and quantum results.The COVID19 supercomputing project that simulates what would happen with different drugs.The AI-generated potential therapeutics for COVID19 analyzed by humans in virtual reality.How Nanome is being used to analyze battery cells.The food and beverage industry's relationship with Nanome's technology.What vision they are building for: a world where everyone has a VR or AR headset.Nanome's investor and funding journey during the pandemic.How seeing Google Hardboard for the first time changed everything for Keita.“We're very mission-driven about what science ought to look like, and we know that science ought to look collaborative, it ought to look intuitive, it ought to look obvious. These are some of the problems, a lot of science isn't like that right now.” — @KeitaWF [0:04:37]“It is very much within our vision and passion to lower the barrier to entry to these types of complex data and science, as a whole. Education has also been a pretty big part of this.” — @KeitaWF [0:05:46]“What does the next generation scientific interface look like when everybody has a VR or AR headset just like they do a smartphone? That's the vision that we're building for.” — @KeitaWF [0:25:00]Links Mentioned in Today's Episode:Keita Funakawa on TwitterKeita Funakawa on InstagramKeita Funakawa on LinkedInNanomeNanome on YouTubePearly Chen on TwitterVIVE

In this episode of the “Nano Matters” podcast, Jim Schuck, Associate Professor of Mechanical Engineering at Columbia University, describes the techniques he and his team have developed to improve the resolution of optical microscopes and better characterize materials at the nanoscale. If you would like to learn more about nanotechnology, go to nano.gov or email us at info@nnco.nano.gov. Closed captioning is provided on our Youtube Channel. For this episode, go to: https://youtu.be/zN5hKyBKLN8 CREDITS Special thanks to:  Jim SchuckColumbia University Produced by:Andrew Pomeroy Music:  Inspirational Outlook by Scott Holmes  https://freemusicarchive.org/music/Sc...https://creativecommons.org/licenses/... Any opinions, findings, conclusions, or recommendations expressed in this podcast are those of the guest and do not necessarily reflect the views of the National Nanotechnology Coordination Office or United States Government. Additionally, mention of trade names or commercial products does not constitute endorsement or recommendation by any of the aforementioned parties. Any mention of commercial products, processes, or services cannot be construed as an endorsement or recommendation.

Sometimes, the biggest discoveries have to do with the smallest things. In this case, we're talking nano. Specifically, nanocrystals. World-renowned chemist Paul Alivisatos has changed the field of nanoscience with these tiny crystals, but he's also found ways to use them to create incredible new technologies in healthcare, energy, and electronic devices. As if that weren't enough, Paul Alivisatos is also an eminent leader in academia. He was the Executive Vice Chancellor and Provost at the University of California, Berkley and is now the President of the University of Chicago. In that role, he hopes to implement his vision of an “engaged university” to push forward the role of academia in society.

In this episode of the “Stories from the NNI” podcast, Ange Akono, an Assistant Professor of Civil and Environmental Engineering at Northwestern University, discusses her work on improving the properties of cement by studying its behavior at the nanoscale.   If you would like to learn more about nanotechnology, go to nano.gov or email us at info@nnco.nano.gov. Closed captioning is provided on our YouTube channel. For this episode, go to: https://youtu.be/A95_lLAg89I CREDITS Special thanks to:  Ange AkonoNorthwestern University Produced by:Andrew Pomeroy Music:  Inspirational Outlook by Scott Holmes  https://freemusicarchive.org/music/Sc...https://creativecommons.org/licenses/... Any opinions, findings, conclusions, or recommendations expressed in this podcast are those of the guest and do not necessarily reflect the views of the National Nanotechnology Coordination Office or United States Government. Additionally, mention of trade names or commercial products does not constitute endorsement or recommendation by any of the aforementioned parties. Any mention of commercial products, processes, or services cannot be construed as an endorsement or recommendation.

In this episode Pranoti sits down with Ferry Prins, Group Leader in the Condensed Matter Physics Center at the Universidad Autonoma de Madrid at the time of recording, to take a deeper dive into Ferry‘s research journey. This vintage episode of the Under the Microscope podcast was originally released on 14.07.2021.

This episode's guest is Ferry Prins, who was a Group Leader in the Condensed Matter Physics Center at the Universidad Autonoma de Madrid at the time of recording. This vintage episode of the Under the Microscope podcast was originally released on 12.07.2021.

In this episode of the “Stories from the NNI” podcast, Lisa Friedersdorf, Director of the National Nanotechnology Coordination Office, speaks with Prof. Himanshu Jain, the T.L. Diamond Distinguished Chair in Engineering and Applied Science at Lehigh University, about the unique properties of glass, from the nanoscale to the macroscale. If you would like to learn more about nanotechnology, go to nano.gov or email us at info@nnco.nano.gov. Closed captioning is provided on our YouTube channel. For this episode, go to: https://youtu.be/H0lF-jxbXEg CREDITS Special thanks to:  Himanshu JainLehigh University Produced by:Andrew Pomeroy Music:  Inspirational Outlook by Scott Holmes  https://freemusicarchive.org/music/Sc...https://creativecommons.org/licenses/... Any opinions, findings, conclusions, or recommendations expressed in this podcast are those of the guest and do not necessarily reflect the views of the National Nanotechnology Coordination Office or United States Government. Additionally, mention of trade names or commercial products does not constitute endorsement or recommendation by any of the aforementioned parties. Any mention of commercial products, processes, or services cannot be construed as an endorsement or recommendation.

This episode is also available as a blog post: http://biopatrika.com/2021/05/29/interview-controlling-molecular-signatures-nanoscale-live-cells-using-light/

In this episode of the “Stories from the NNI” podcast, Jim Schuck, Associate Professor of Mechanical Engineering at Columbia University, discusses his work on developing optical techniques to probe materials at the nanoscale. If you would like to learn more about nanotechnology, go to nano.gov or email us at info@nnco.nano.gov. Closed captioning is provided on our YouTube channel. For this episode, go to: https://youtu.be/C-trmuIZi60 CREDITS Special thanks to:  Jim SchuckColumbia University Produced by:Andrew Pomeroy Music:  Inspirational Outlook by Scott Holmes  https://freemusicarchive.org/music/Sc...​https://creativecommons.org/licenses/...​ Any opinions, findings, conclusions, or recommendations expressed in this podcast are those of the guest and do not necessarily reflect the views of the National Nanotechnology Coordination Office or United States Government. Additionally, mention of trade names or commercial products does not constitute endorsement or recommendation by any of the aforementioned parties. Any mention of commercial products, processes, or services cannot be construed as an endorsement or recommendation.

In this episode of Nano Matters, Clarice Aiello, Assistant Professor and quantum engineer at UCLA, discusses what she has learned about biology at the nanoscale  using quantum sensors.   If you would like to learn more about nanotechnology, go to nano.gov or email us at info@nnco.nano.gov. Closed captioning is provided on our YouTube channel. For this episode, go to: https://youtu.be/8k1NC2AFweA  CREDITS Special thanks to:  Clarice AielloUCLA Music:  Inspirational Outlook by Scott Holmes  https://www.freemusicarchive.org/musi...​https://creativecommons.org/licenses/...​ Produced by:  Andrew Pomeroy Any opinions, findings, conclusions, or recommendations expressed in this podcast are those of the guest and do not necessarily reflect the views of the National Nanotechnology Coordination Office or United States Government. Additionally, mention of trade names or commercial products does not constitute endorsement or recommendation by any of the aforementioned parties. Any mention of commercial products, processes, or services cannot be construed as an endorsement or recommendation.

Diatoms, a group of tiny algae, are also known as “living opals” because of the strange, beautiful properties of their silica shells. But what genes are responsible for such mesmerizing exteriors? Setsuko Wakao and Kris Niyogi, biologists at UC Berkeley and Lawrence Berkeley National Laboratory, aim to find out. Find more info on this episode, including the transcript, at https://jgi.doe.gov/genome-insider-s2ep2-cracking-the-secrets-of-the-diatoms-shell/.

In This episode Pranoti sits down with Laia Delgado Callico, PhD Student at King's College London at the time of recording, to take a deeper dive into Laia‘s research journey. This vintage episode of the Under the Microscope podcast was originally released on 03.03.2021.

This episode's guest is Laia Delgado Callico, who was a PhD Student at King's College London at the time of recording. This vintage episode of the Under the Microscope podcast was originally released on 01.03.2021.

Professor Adam Foster is an overseas PI at the WPI Nano Life Science Institute (WPI-NanoLSI) and leader of the Surface and Interfaces at the Nanoscale at Aalto University in Finland. Here, he describes his research on computational physics for modelling complex scanning probe images and the development of sophisticated machine learning software for running semi-autonomous SPM systems.  The Kanazawa University NanoLSI Podcast offers updates of the latest news and research at the WPI-NanoLSI Kanazawa University. The Nano Life Science Institute (NanoLSI) at Kanazawa University was established in 2017 as part of the World Premier International (WPI) Research Center Initiative of the Ministry of Education, Culture, Sports, Science and Technology (MEXT). Researchers at the NanoLSI are combining their cutting-edge expertise in scanning probe microscopy to establish ‘nano-endoscopic techniques' to directly image, analyze, and manipulate biomolecules for insights into mechanisms governing life phenomena such as diseases. Further information WPI-NanoLSI Kanazawa University website https://nanolsi.kanazawa-u.ac.jp/en/

Chris Phoenix (futurist, nanotechnologist and software engineer) is today's featured guest. Topics: Trends in nanotechnology and molecular manufacturing; methods of getting to the nanoscale; the problem with MEMS (microelectromechanical systems); some of the benefits of "scaling down" to the nanoscale; benefits of molecular manufacturing; and medical benefits from nanotechnology. Also trends in fusion; the rise of space access; and his involvement with a satellite called SkyCube, which will be launched into space on a SpaceX Falcon 9. Hosted by Stephen Euin Cobb, this is the June 27, 2012 episode of The Future And You. [Running time: 35 minutes] This interview was recorded using Skype on June 23, 2012. Chris Phoenix is a tech geek and software engineer currently working on projects including a CubeSat, health-related electronic devices, and astronomy hardware and software. From Stanford University, he obtained his BS in Symbolic Systems and MS in Computer Science. Previous careers have included dyslexia correction and co-founding the Center for Responsible Nanotechnology. In his spare time, he sings in an internationally competitive barbershop chorus, pursues extreme sports, and theorizes on major world problems.