Podcasts about immunoglobulin

In this podcast, expert faculty Atul Humar, MD, FRCP (C), and Camille Kotton, MD, FIDSA, FAST, take a deep dive into complex clinical scenarios and explore designing antiviral regimens for refractory CMV infections to minimize antiviral toxicities and maximize efficacy. Topics covered include:Management for suspected drug-resistant CMV infection Illustrative patient cases Gene mutations in CMV  Presenters:Atul Humar, MD, FRCPC, FASTProfessorDepartment of MedicineUniversity of TorontoEaton Family Chair in Transplant Infectious DiseasesAjmera Transplant CentreUniversity Health NetworkToronto, CanadaCamille Kotton, MD, FIDSA, FAST Clinical Director, Transplant and Immunocompromised Host Infectious DiseasesInfectious Diseases DivisionMass General Brigham Endowed Cancer Chair IVMassachusetts General HospitalAssociate Professor, Harvard Medical SchoolBoston, MassachusettsLink to full program:https://bit.ly/4lOa2kAGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.

Learn to appropriately modify antiviral therapy in solid organ transplant recipients with treatment-refractory cytomegalovirus (CMV) infections with expert faculty, Atul Humar, MD, FRCP (C). Topics covered include:Comparisons of available CMV antiviral therapies:Ganciclovir, valganciclovir, foscarnet, cidofovir, maribavirConsiderations for renal function monitoring with ganciclovir and valganciclovirA treatment algorithm for relapsed/refractory CMVThe latest clinical trial data and guideline recommendationsPresenter:Atul Humar, MD, FRCP (C) ProfessorDepartment of MedicineUniversity of TorontoEaton Family Chair in Transplant Infectious DiseasesAjmera Transplant CentreUniversity Health NetworkToronto, CanadaLink to full program:https://bit.ly/4lOa2kAGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify

Tune in to learn the fundamentals for timely identification of refractory cytomegalovirus (CMV) infections following solid organ transplantation from expert faculty, Camille Kotton, MD, FIDSA, FAST. Topics covered include:Direct and indirect effects of CMV infectionRisk factors for resistant/refractory CMVDefining resistant/refractory CMVPresenter:Camille Kotton, MD, FIDSA, FAST Clinical Director, Transplant and Immunocompromised Host Infectious DiseasesInfectious Diseases DivisionMass General Brigham Endowed Cancer Chair IVMassachusetts General HospitalAssociate Professor, Harvard Medical SchoolBoston, MassachusettsLink to full program:http://bit.ly/4lOa2kAGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.

In the latest bonus podcast, the practical use of intravenous immunoglobulin is discussed with perspectives from three continents. Participants: Professor Alasdair Coles is Head of Department for Clinical Neuroscience and also Co-Director of the Cambridge Centre for Myelin Repair, UK. Dr. Lynette Kiers is a Clinical Associate Professor at The University of Melbourne, and Director of Clinical Neurophysiology at the Royal Melbourne Hospital, Australia. Dr. Christopher Hahn is an Associate Clinical Professor of Neurology at the University of Calgary's Cumming School of Medicine, and the Medical Director of the Calgary Electromyography Lab, Canada. Read the paper (https://pn.bmj.com/content/25/3/228) which is part of the June issue of the Practical Neurology journal.   Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production and editing by Letícia Amorim. Thank you for listening. 

Today I'm happy to chat with our patient Leslie who shares her successful journey with histamine intolerance healing. We'll go through how SIBO led to her histamine issues, the connection to low vagus nerve tone, as well as the low histamine diet and treatments such as dao enzymes. Tune in to learn how you can reduce histamine in the body naturally.    Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/ Histamine Intolerance and Diet Guide: https://drruscio.com/guides/get-histamine-intolerance-guide/  

This episode's theme is new diseases, whether they are newly described, or old diseases back in a new form. We start off with IgG4-related disease, a chronic multisystem disorder that is still being understood. Then there is a genetics paper on repeat expansion disorders, a group of conditions often thought as disparate but with quite a few commonalities. Next along is a fascinating case following gastric sleeve bariatric surgery, highlighting the dangers of travelling for unsupervised surgeries, and raising the question, “Are you getting enough soil in your diet?” There's also a discussion of what else Hoover's sign might represent, and the evolution of immunoglobulin use. Closing the episode is a paper offering a masterclass on the assessment of best interests in  prolonged disorder of consciousness.   Read the issue: https://pn.bmj.com/content/25/3/199   Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production and editing by Brian O'Toole. Thank you for listening. 

Episode 190: Measles BasicsFuture Dr. Kapur explained the basics of measles, including the pathophysiology, diagnosis and management of this disease. Dr. Schlaerth added information about SPPE and told interesting stories of measles. Dr. Arreaza explained some statistics and histed the episode.  Written by Ashna Kapur MS4 Ross University School of Medicine. Comments by Katherine Schlaerth, MD, and Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Introduction.According to the CDC, as of April 24, 2025, a total of 884 confirmed measles cases were reported by 30 states, including California, and notably Texas. This is already three times more cases than 2024. There are 3 confirmed deaths so far in the US. What is measles?Measles is a disease that's been around for centuries, nearly eradicated, yet still lingers in parts of the world due to declining vaccination rates. Let's refresh our knowledge about its epidemiology, clinical features, diagnosis, management, and most importantly — prevention.Definition.Measles, also known as rubeola, is an acute viral respiratory illness caused by the measles virus. It's a single-stranded, negative-sense RNA virus belonging to the Paramyxoviridae family. It's extremely contagious with a transmission rate of up to 90% among non-immune individuals when exposed to an infected person.EpidemiologyBefore the introduction of the measles vaccine in 1963, nearly every child got measles by the time they were 15 years old. With the introduction of vaccination, cases and deaths caused by measles significantly declined. For example, in 2018, over 140,000 deaths were reported in the whole world, mostly among children under the age of 5.Measles is still a common disease in many countries, including in Europe, the Middle East, Asia, and Africa. Measles outbreaks have been reported recently in the UK, Israel, India, Thailand, Vietnam, Japan, Ukraine, the Philippines, and more recently in the US. So, let's take prevention seriously to avoid the spread of this disease here at home and abroad. How do we get measles, Ashna?Mode of Transmission:● Air: Spread primarily through respiratory droplets.● Surfaces: The virus remains viable on surfaces or in the air for up to 2 hours. (so, if a person with measles was in a room and you enter the same room within 2 hours, you may still get measles)● Other people: Patients are contagious from 4 days before until 4 days after the rash appears.PathophysiologyThe measles virus first infects the respiratory epithelium, replicates, and then disseminates to the lymphatic system.It leads to transient but profound immunosuppression, which is why secondary infections are common. It affects the skin, respiratory tract, and sometimes the brain, leading to complications like pneumonia or encephalitis.Clinical PresentationThe classic presentation of measles can be remembered in three C's:● Cough● Coryza (runny nose)● ConjunctivitisCourse of Disease (3 Phases):1. Prodromal Phase (2-4 days)○ High fever (can peak at 104°F or 40°C)○ The 3 C's○ Koplik spots: Small white lesions on the buccal mucosa.2. Exanthem Phase○ Maculopapular rash begins on the face (especially around the hairline), then spreads from head to toe. The rash typically combines into 1 big mass as it spreads, and the fever often persists during the rash.3. Recovery Phase○ Rash fades in the same order it appeared.○ Patients remain at risk for complications during and after rash resolution.Complications:● Pneumonia (most common cause of death in children)● Otitis media (most common overall complication)● Encephalitis (can lead to permanent neurologic sequelae)● Subacute sclerosing panencephalitis (SSPE): A rare, fatal, degenerative CNS disease that can occur years after measles infection.High-risk groups for severe disease include:● Infants and young children● Pregnant women● Immunocompromised individualsDiagnosisClinical diagnosis is sufficient if classic symptoms are present, especially in outbreak settings.Ashna: Laboratory confirmation:● Measles-specific IgM antibodies detected by serology.● RT-PCR from nasopharyngeal, throat, or urine samples.Notify public health authorities immediately upon suspicion or diagnosis of measles to limit spread. ManagementThere is no specific antiviral treatment for measles. Management is supportive:● Hydration (by mouth and only IV in case of severe dehydration)● Antipyretics (e.g., acetaminophen) for fever● Oxygen if hypoxicVitamin A supplementation:● Recommended for all children with acute measles, particularly in areas with high vitamin A deficiency. It has shown to reduce morbidity and mortality.Hospitalization may be necessary for:● Severe respiratory compromise● Dehydration● Neurologic complicationsPrevention: We live in perilous times and vaccination is under scrutiny right now. Before the measles vaccine, about 48,000 people were hospitalized and 400–500 people died in the United States every year. Measles was declared eradicated in the US in 2000, but the vaccination coverage is no longer 95%. How do we prevent measles?Vaccination is the cornerstone of prevention.● MMR vaccine (Measles, Mumps, Rubella):○ First dose at 12-15 months of age.○ Second dose at 4-6 years of age.○ 97% effective after 2 doses.The Advisory Committee on Immunization Practices (ACIP) has noted that febrile seizures typically occur 7 to 12 days after vaccination with MMR, with an estimated incidence of 3.3 to 8.7 per 10,000 doses. The Centers for Disease Control and Prevention (CDC) states that febrile seizures following MMR vaccination are rare and not associated with any long-term effects. The risk of febrile seizures is higher when the MMR vaccine is administered as part of the combined MMRV (measles, mumps, rubella, and varicella) vaccine compared to the MMR vaccine alone.Post-exposure prophylaxis:● MMR vaccine within 72 hours of exposure (if possible).● Immunoglobulin within 6 days for high-risk individuals (e.g., infants, pregnant women, immunocompromised).Herd immunity requires at least 95% vaccination coverage to prevent outbreaks.Key Takeaways● Measles is a highly contagious viral illness that can lead to severe complications.● Diagnosis is often clinical, but lab confirmation helps with public health tracking.● Treatment is mainly supportive, with Vitamin A playing a critical role in reducing complications.● Vaccination remains the most effective tool to eliminate measles worldwide.While measles might seem like a disease of the past, it can make a dangerous comeback without continued vigilance and vaccination efforts.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References:Centers for Disease Control and Prevention (CDC). Measles (Rubeola), Clinical Overview, July 15, 2024. Accessed on May 1, 2025. https://www.cdc.gov/measles/hcp/clinical-overview/index.html.World Health Organization (WHO). Measles, November 14, 2024. https://www.who.int/news-room/fact-sheets/detail/measlesGans, Hayley and Yvonne A. Maldonado, Measles: Clinical manifestations, diagnosis, treatment, and prevention, UpToDate, January 15, 2025. Accessed on May 1, 2025. https://www.uptodate.com/contents/measles-clinical-manifestations-diagnosis-treatment-and-preventionTheme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.

The May 2025 recall features four previously posted episodes on myasthenia gravis. The first episode has Dr. Fredrik Piehl discussing rituximab for new-onset generalized MG. In the second episode, Dr. Vera Bril explores the potential use of immunoglobulin as a corticosteroid-sparing agent in MG patients. The third episode features Dr. Ali A. Habib discussing trends in hospital admissions and in-hospital mortality for adult MG patients. The series concludes with Dr. Jennifer Morganroth addressing the increase in thymectomy procedures post-MGTX trial, disparities in access to these surgeries among different demographic groups, and the rise of minimally invasive surgical techniques. Podcast links: Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis  Corticosteroid-Sparing Effects of Immunoglobulin in Myasthenia Gravis Hospitalizations and Mortality from MG Hospitalizations and Mortality From Myasthenia Gravis Trends and Disparities in the Utilization of Thymectomy for MG in the US Article links: Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis Randomized Double-Blind Placebo-Controlled Trial of the Corticosteroid-Sparing Effects of Immunoglobulin in Myasthenia Gravis Hospitalizations and Mortality From Myasthenia Gravis Trends and Disparities in the Utilization of Thymectomy for Myasthenia Gravis in the United States Disclosures can be found at Neurology.org.

In this episode, we discuss the relationship between the intestinal mucus layer and secretory immunoglobulin A (sIgA), highlighting both as key components of the gut's first line of defense against pathogens, toxins, and environmental stressors. We detail how dysbiosis and microbial overgrowths can impact sIgA levels and can disrupt mucus integrity and function, contributing to increased intestinal permeability and inflammation. We then examine several additional factors influencing sIgA production. Topics: 1. Introduction: Importance of Secretory IgA and Intestinal Mucus     - Intestinal epithelial lining and its protective mucus layer     - Focus on intestinal dysbiosis and sIgA   2. Anatomy of the Gastrointestinal Lining     - Intestinal lumen, microbiome, mucus layer, epithelial cells, tight junctions, lamina propria, and smooth muscle     - Role of goblet cells in mucus secretion and epithelial integrity    3. Role of the Protective Mucus Layer     - Dual function of the mucus layer as a physical and biochemical barrier     - Composition of mucus: mucins, antimicrobial peptides, immunoglobulins    4. Goblet Cells and Mucin Production     - Mechanisms of mucin secretion and hydration     - Variability in goblet cell density across the intestinal tract     - Dysfunctions linked to conditions like IBD and IBS    5. Microbial Interactions with Mucins     - Glycan structures in mucins    - Roles of commensal and pathogenic bacteria in mucin degradation and mucus turnover     - Importance of regulated mucus production for gut homeostasis    6. Dysbiosis and Mucus Degradation     - Excessive mucin degradation leading to thinning of the mucus layer     - Consequences of increased intestinal permeability and inflammation     - Role of dysbiosis in disrupting the mucus layer    7. Overview of Secretory IgA     - Introduction to secretory IgA (sIgA) and its role in mucosal immunity    - Mechanisms of immune exclusion and pathogen neutralization    8. Production and Function of Secretory IgA     - sIgA production by plasma cells in the lamina propria     - Translocation of IgA through epithelial cells into the gut lumen     - sIgA binding to mucins and its immunological role in the mucus layer    9. Factors Affecting Secretory IgA Levels     - Possible contributing factors to low sIgA levels    - Implications of low and high sIgA levels for immune defense and intestinal health    10. Interactions Between Secretory IgA and Dysbiosis     - Cyclical relationship between low sIgA, dysbiosis, and infections     - Examples of overgrowths, like candida, disrupting sIgA     - Importance of addressing immune dysregulation to break the cycle    11. Bioindividual Root Cause Approach  - Factors to consider Thank you to our episode sponsors: 1. Shop ⁠⁠Fresh Press Farms⁠⁠' Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection ⁠⁠here⁠⁠. 2. Check out ⁠Spectrum Sciences⁠' Serums and The Vitamin B12 Protocol ⁠here⁠, and use code CHLOE15 for 15% off. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

In this episode, we go through the gut-immune axis and mycobiome, focusing on the mechanisms underlying intestinal fungal overgrowth. We highlight the roles of the intestinal mucus layer, intestinal epithelial cells, lamina propria, and secretory immunoglobulin A (sIgA) in maintaining homeostasis and defending against fungal overgrowth. We also detail the pathogenic transition of Candida from its commensal yeast form to an invasive hyphal state, as well as the resulting disruptions to immune function. Topics 1. Introduction to the Gut-Immune Axis and Mycobiome    - The gut-immune axis and mycobiome.    - Exploring intestinal fungal overgrowth.   2. Overview of the Gastrointestinal Lining    - Anatomy of the intestinal lining: lumen and microbiome, mucus layer, epithelial monolayer, and lamina propria.    - The dual role of the mucus layer: physical and biochemical barrier.    - Composition of mucus.   3. Goblet Cells and Mucus Production    - Goblet cells as critical producers of mucin glycoproteins and their role in mucus barrier integrity.    - Signals for mucin release, such as mechanical stress.   4. The Lamina Propria and Gut-Associated Lymphoid Tissue (GALT)    - Layers beneath the epithelium    - Peyer's patches, mesenteric lymph nodes, isolated lymphoid follicles, and intraepithelial lymphocytes.    - Immune tolerance and defense against pathogens.   5. Peyer's Patches    - Positioning of Peyer's patches.    - The transition of microbial density from the small intestine to the colon and its immune implications.   6. Immune Cells in the Lamina Propria    - Overview of macrophages, dendritic cells, mast cells, plasma cells, and lymphocytes.    - Their role in maintaining immunological equilibrium in the gut.   7. The Mycobiome and Pathogenic Transition of Candida    - Candida's transition from yeast to hyphal form.    - Regulation of Candida by microbial competition and immune surveillance.    - Factors promoting pathogenicity: immune suppression, lacking beneficial microbes, more.   8. Virulence Factors of Candida    - Secretion of hydrolytic enzymes such as SAPs and phospholipases.    - Degradation of sIgA and its consequences for immune evasion.    - Adhesins that facilitate fungal binding.   9. Intestinal Barrier Disruption by Candida    - Penetration of the mucus layer and epithelial barrier by Candida hyphae.    - Disruption of tight junctions and the resulting increased intestinal permeability.    - Inflammatory cascade triggered by fungal antigens and microbial toxins entering the lamina propria.   10. Biofilm Formation     - The role of biofilms in shielding fungal cells from immune attack and antifungal treatments.   11. Small Intestinal Fungal Overgrowth (SIFO)     - Intestinal dysmotility, low stomach acid, immunocompromise.     - Possible symptoms of SIFO.     - Discussion of the overlap between SIFO, SIBO, histamine intolerance, and other gastrointestinal conditions. - Root cause. Thank you to our episode sponsors: 1. Shop ⁠Fresh Press Farms⁠' Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection ⁠here⁠. 2. Check out ⁠⁠⁠⁠⁠Ulyana Organics'⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Tallow Wild Yam Cream⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠Healing Facial Oil⁠⁠⁠⁠⁠, and use code ⁠⁠⁠⁠⁠CHLOE10⁠⁠⁠⁠⁠ 10% off your order. 3. Check out Spectrum Sciences' Serums and The Vitamin B12 Protocol here, and use code CHLOE15 for 15% off. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Today, Fei and Nick are joined by Dr. Sarah Prager and Dr. Sarah Horvath to talk about the new recommendations for Rh immunoglobulin administration in early pregnancy. Should we still be giving it for bleeding in early pregnancy? If so, how much?  Dr. Sarah Prager is a Professor of Obstetrics and Gynecology and Division Chief of Complex Family Planning at the University of Washington Medical Center.  Dr. Sarah Horvath is an Associate Professor of Obstetrics and Gynecology and Vice Chair of Research at Penn State.  Twitter: @creogsovercoff1 Instagram: @creogsovercoffee Facebook: www.facebook.com/creogsovercoffee Website: www.creogsovercoffee.com Patreon: www.patreon.com/creogsovercoffee You can find the OBG Project at: www.obgproject.com

The Balchem technical team selected abstracts of interest from the 2024 American Dairy Science Association meetings to feature on this episode of the Real Science Exchange. Whole Cottonseed and Fatty Acid Supplementation Affect Production Responses During the Immediate Postpartum in Multiparous Dairy CowsGuests: Jair Parales-Giron and Dr. Adam Lock, Michigan State University (0:58)The experiment had four treatment groups: no fat supplement, 10% of the diet from whole cottonseed, a 60:30 mix of calcium salts of palmitic and oleic acid at 1.5% of the diet dry matter, and a combination of both whole cottonseed and fatty acid supplement. Energy-corrected milk was increased by almost six kilograms in cows fed the whole cottonseed diet, with a similar increase of more than five kilograms in the fatty acid-supplemented cows during the first 24 days of lactation. However, no further improvement was observed when both whole cottonseed and fatty acids were fed together. The increase in milk production was not accompanied by increased weight loss or loss of body condition. Effect of Close-Up Metabolizable Protein Supply on Colostrum Yield, Composition, and Immunoglobulin G ConcentrationGuests: Dr. Trent Westhoff and Dr. Sabine Mann, Cornell University (17:06)In this study, cows were assigned to one of two diets 28 days before expected calving: one that provided 39 grams of metabolizable protein (MP) per pound of dry matter and one that supplied 51 grams of MP per pound of dry matter. This represents about 100% of the MP requirement and 140% of the MP requirement, respectively. Diets were formulated to supply equal amounts of methionine and lysine. Cows entering their second parity who were fed the elevated MP diet produced two liters more colostrum than second parity cows fed the control MP diet. This effect was not observed in cows entering their third or higher parity. Overall, higher MP supply did not impact colostrum quantity or quality. Dr. Westhoff also highlights an invited review he authored regarding nutritional and management factors that influence colostrum production and composition. The MP research has also been published; links to both are below.MP paper: https://www.sciencedirect.com/science/article/pii/S0022030224010774Invited review: https://www.sciencedirect.com/science/article/pii/S0022030224000341Colostrum—More than Immunoglobulin G (IgG): Colostrum Components and Effects on the CalfGuest: Dr. Sabine Mann, Cornell University (41:23)Dr. Mann presented this abstract at an ADSA symposium titled “Colostrum: The Role It Plays In Calf Health, Development, and Future Productivity.”  Her focus was to give credit to the importance of IgG while reminding the symposium audience of the importance of other colostrum components like bioactive factors and nutrients. There is potential that measuring IgG could be a marker for all the other colostrum components that have been transferred as well. We have excellent and cost-effective ways to measure IgG calf-side, but very few bioactive factors can be measured as easily. Heat treatment of colostrum to control bacterial contamination has a detrimental effect on many of the non-IgG components of colostrum. More data is needed to learn how impactful this may be to the calf. Dr. Mann details parts of the heat treatment process that farmers can check to make sure heat treatment is having as little impact as possible. She also would like to have a way to measure the antimicrobial activity of colostrum and the concentrations of insulin and IGF-1 in colostrum on-farm. Lastly, she reminds the audience that we can focus a lot on making the best quality colostrum via transition cow management and best management practices for colostrum harvest, but we still need to get it into the calf. Colostrum must get into calves cleanly and safely, at an adequate amount, and at an optimal temperature.Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Ever heard of immunoglobulins? While colostrum is experiencing a renaissance, you should seriously weigh the immunoglobulin supplement versus colostrum benefits.Partly because colostrum is a LOWER potency option, that sometimes isn't even standardized (depending on the brand) to guarantee how helpful it will be.That said, immunoglobulins (aka. IgGs) can be incredibly helpful for things like leaky gut (gut permeability), histamine intolerance, recovering from a stomach bug or food poisoning, and supporting your immune system during cold + flu season.Plus, I'm going to share why I prefer immunoglobulin supplements over colostrum, what the difference is between the two, and how to use them.Also, I want to how you how to avoid the fake, over-hyped colostrum + immunoglobulin supplements found online (even on Amazon)!Let's dive in!In This Episode:How I learned about the amazing benefits of immunoglobulin supplementWhy you should use immunoglobulinsDifference between immunoglobulins and colostrum benefitsHow do immunoglobulins work?Benefits of immunoglobulinsHow to take an immunoglobulin supplementBest immunoglobulin supplement + where to get itQuotes“[Immunoglobulins] were traditionally used and still are actually for more diarrhea-dominant problems. So if you've got a lot of loose soft stools, diarrhea, or even something like inflammatory bowel disease.”“IgGs can be found in the serum of your blood, and they also can be found in the serum of the blood of cows. And so historically, when people supplement with colostrum, that's derived from dairy, and it contains IgGs. So they are similar in that colostrum has IgGs and it's one of the major components that makes it so helpful, but it's not as potent.”LinksGET REAL, VERIFIED IMMUNOGLOBULINS HEREHealthy Skin Show ep. 188: Histamine Intolerance + Skin Rashes (PART 1)Healthy Skin Show ep. 192: Histamine Intolerance + Skin Rashes, PART 2

Oncimmune Holdings CEO Martin Gouldstone joined Steve Darling from Proactive to provide an encouraging trading update on the company's recent commercial progress. Over the last quarter, Oncimmune has continued its positive momentum, signing three new contracts valued at £0.34 million. These add to an impressive streak, bringing the total to eight contracts worth £2.14 million secured in just three months. Two of the latest agreements mark a significant expansion, as they involve new work areas for an existing top 10 global pharmaceutical client, highlighting Oncimmune's growing versatility and value to major industry players. The third contract leverages Oncimmune's expertise in profiling Immunoglobulin type E (IgE) autoantibodies, further solidifying its relationship with another top-tier pharmaceutical partner. Though these contracts do not prompt an increase in the FY2025 revenue outlook, they strengthen Oncimmune's position to meet market expectations. The company now has visibility of over 40% of its FY2025 revenue target of £6.9 million, supported by a robust, high-confidence pipeline. This ongoing success underscores Oncimmune's expanding commercial traction and its position as a trusted partner to leading pharmaceutical companies worldwide. #proactiveinvestors #oncimmuneholdingsplc #aim #onc.l #AutoantibodyProfiling #PharmaContracts #BiotechNews #IgEInnovation #Immunology #AutoimmuneDisease #CancerResearch #PharmaIndustry #ProactiveInvestors #MedicalResearch #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews

Learn about Serum Bovine Immunoglobulin (SBI) Powder, a game-changer in gut health with Brian Kaufman, RN, Vice President of Global Business Development for Proliant Health & Biologicals. By selectively removing gut pathogens without disturbing commensal bacteria, SBIs help in conditions as diverse as SIBO, IBS, Candida, Crohn's, colitis, malnutrition, leaky gut, cancer, HIV, psoriasis and acute gut infections like C Difficile. Learn how this plasma-derived bovine immunoglobulin (IgG) supplement facilitates gut healing and improves nutrient absorption while preserving the microbiome. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Tiktok, X, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up a free 30-minute Gut Healing Breakthrough Session. Show Notes

Here are the most prominent News Highlights of Sri Lanka. Manoj Udatiyawala reports - SBS සිංහල සේවය ගෙනෙන "මවුබිමෙන් පුවත්" - මාධ්‍යවේදී මනෝජ් උදටියාවල ශ්‍රී ලංකාවේ සිට වාර්තා කරයි.

Martin van Hagen, MD, PhD - Patients Receiving Immunoglobulin Therapy: Emerging Technology for Patient-Integrated Care

Martin van Hagen, MD, PhD - Patients Receiving Immunoglobulin Therapy: Emerging Technology for Patient-Integrated Care

Martin van Hagen, MD, PhD - Patients Receiving Immunoglobulin Therapy: Emerging Technology for Patient-Integrated Care

Martin van Hagen, MD, PhD - Patients Receiving Immunoglobulin Therapy: Emerging Technology for Patient-Integrated Care

Dr. Corey Watson is an Associate Professor at the University of Louisville. His work focuses on characterising and cataloguing antibody genetic diversity in human and mouse to better understand disease susceptibility and clinical health outcomes. Dr. William Lees is a researcher at University of London. His work focuses on developing Adaptive Immune Receptor (AIR) reference sets for diverse species and the annotation of experimental sequence data. In this episode we talk about the recent work by the Germline Database Working Group of the AIRR-Community. The accuracy of V and J gene segment assignment improves with the quality of the reference germline set. The accurate assignment is critical for characterization of somatic hypermutation. We discuss the challenges in creating a database to hold all relevant and potentially relevant germline information, especially in the light of increased discovery rate through technological advances and improved analysis pipelines. We also reflect on the complexity in handling personalised germline reference sets. The episode is hosted by Dr. Ulrik Stervbo and Dr. Zhaoqing Ding. Comments are welcome to the inbox of onairr@airr-community.org  or on social media under the tag #onAIRR. Further information can be found here: https://www.antibodysociety.org/the-airr-community/airr-c-podcast.  Website of the AIRR-C Germline Database Working Group https://www.antibodysociety.org/the-airr-community/airr-working-groups/germline_database/  Papers mentioned Collins, Andrew M., Mats Ohlin, Martin Corcoran, James M. Heather, Duncan Ralph, Mansun Law, Jesus Martínez-Barnetche, et al. 2023. “AIRR-C Human IG Reference Sets: Curated Sets of Immunoglobulin Heavy and Light Chain Germline Genes.” BioRxiv. https://doi.org/10.1101/2023.09.01.555348  Rodriguez, Oscar L., Yana Safonova, Catherine A. Silver, Kaitlyn Shields, William S. Gibson, Justin T. Kos, David Tieri, et al. 2023. “Genetic Variation in the Immunoglobulin Heavy Chain Locus Shapes the Human Antibody Repertoire.” Nature Communications 14 (1). https://doi.org/10.1038/s41467-023-40070-x  Lees, William D., Scott Christley, Ayelet Peres, Justin T. Kos, Brian Corrie, Duncan Ralph, Felix Breden, et al. 2023. “AIRR Community Curation and Standardised Representation for Immunoglobulin and T Cell Receptor Germline Sets.” Immunoinformatics (Amsterdam, Netherlands) 10 (100025): 100025. https://doi.org/10.1016/j.immuno.2023.100025  Jackson, Katherine J. L., Justin T. Kos, William Lees, William S. Gibson, Melissa Laird Smith, Ayelet Peres, Gur Yaari, et al. 2022. “A BALB/c IGHV Reference Set, Defined by Haplotype Analysis of Long-Read VDJ-C Sequences From F1 (BALB/c x C57BL/6) Mice.” Frontiers in Immunology 13. https://doi.org/10.3389/fimmu.2022.888555  Ford, Easton E., David Tieri, Oscar L. Rodriguez, Nancy J. Francoeur, Juan Soto, Justin T. Kos, Ayelet Peres, et al. 2023. “FLAIRR-Seq: A Method for Single-Molecule Resolution of near Full-Length Antibody H Chain Repertoires.” The Journal of Immunology 210 (10): 1607–19. https://doi.org/10.4049/jimmunol.2200825  Omer, Aviv, Ayelet Peres, Oscar L. Rodriguez, Corey T. Watson, William Lees, Pazit Polak, Andrew M. Collins, and Gur Yaari. 2022. “T Cell Receptor Beta Germline Variability Is Revealed by Inference from Repertoire Data.” Genome Medicine 14 (1). https://doi.org/10.1186/s13073-021-01008-4  Rodriguez, Oscar L., Catherine A. Silver, Kaitlyn Shields, Melissa L. Smith, and Corey T. Watson. 2022. “Targeted Long-Read Sequencing Facilitates Phased Diploid Assembly and Genotyping of the Human T Cell Receptor Alpha, Delta, and Beta Loci.” Cell Genomics 2 (12): 100228. https://doi.org/10.1016/j.xgen.2022.100228  Tools mentioned TIgGER (Immcantation) https://tigger.readthedocs.io/en/stable  IgDiscover https://github.com/NBISweden/IgDiscover  Partis https://github.com/psathyrella/partis MiXCR https://mixcr.com

Did you know that modulation of the neonatal Fc receptor (FcRn) can improve outcomes for patients with immunoglobulin G-mediated autoimmune diseases?    Credit available for this activity expires: 11/08/2024 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/995314?ecd=bdc_podcast_libsyn_mscpedu

Are you struggling with food sensitivities but don't want to eliminate your favorite foods? I've got good news for you! In this episode of the Love Your Gut podcast, I had the pleasure of speaking with Brian Kaufman, an expert in digestive health and infectious disease, about how to improve your food sensitivities without having to cut out all the foods you love. Discover how you can achieve the outcome you desire – finding relief from food sensitivities – while still enjoying a wide variety of delicious meals. We dive into the fascinating world of food sensitivities, discussing practical strategies and tips to alleviate symptoms while still enjoying a diverse diet. If you're tired of feeling restricted by your food sensitivities, this episode is a must-listen! Topics covered in this episode: Deep dive the role of serum bovine immunoglobulin in promoting a healthy digestive system.Learn the vital role of immunoglobulins in boosting your body's defenses.Uncover the hidden connection between serum bovine immunoglobulin and the improvement of leaky gut symptoms.Grasp the complex connection between stress and its impact on gut health.Get to know how Immunolin effectively aids in managing and improving digestive health conditionsRecommendations:LMNT electrolytesPurchase Immunogoblin products hereFollow Brian Kauffman:Instagram: https://www.instagram.com/immunolin/Website: https://phb1.com/Follow Dr. HeatherInstagram: https://www.instagram.com/drheatherfinley/Website: https://www.drheatherfinley.co/podcast/KEY MOMENTS:04:57 - The Benefits of Immunoglobulin,09:34 - Importance of Gut Health,10:42 - Why Immunoglobulin is Needed Now,15:27 - Understanding the Safety and Dosing of a Protein Supplement,17:42 - Clinical Efficacy and Dosage for Specific Disease States,19:06 - Personal Experience and Benefits of Immunolin,24:54 - Immunolin and its Binding Properties,30:07 - Accessing the Product,31:15 - Other Products,32:59 - IGGI Shield,34:56 - Positive Implications,36:58 - Life Begins in the Gut, 

Did you know that immunoglobulin A nephropathy has very recently seen 2 treatments first licensed for its management? Credit available for this activity expires: 6/29/24 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/993766?ecd=bdc_podcast_libsyn_mscpedu

Không chỉ phải đối mặt với tình trạng căng thẳng của dịch tay chân miệng khi đã xuất hiện trường hợp tử vong, nhiều ca nặng ở các địa phương phải chuyển về tuyến cuối và nguy cơ dịch chồng dịch, TP.HCM còn phải đối mặt với nguy cơ thiếu thuốc điều trị. Hiện các loại thuốc Immunoglobulin, Pentaglobin (chế phẩm từ huyết tương) và Phenobarbital đang khan hiếm nên việc điều trị gặp nhiều khó khăn.

Warm autoimmune hemolytic anemia (wAIHA) is the most common type (60-70%) of autoimmune hemolytic anemia (AIHA). In most cases, wAIHA is due an immunoglobulin G (IgG) autoantibody that binds to red blood cells (RBC), leading to hemolysis. Current recommendations for managing people with wAIHA are largely based on case series and retrospective studies involving off-label medications. Also, while there are currently no medications specifically approved to treat wAIHA, data are emerging on new therapies under investigation which may impact treatment in the future. This 60-minute CME program, hosted by Irina Murakhovskaya, MD, of the Montefiore Medical Center, Albert Einstein College of Medicine, in New York, NY and Bruno Fattizzo, MD, of the University of Milan and Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, in Milan, Italy, describes current best practices to manage patients with wAIHA.Supported by an educational grant from Janssen Biotech. For complete activity information and to obtain CME credit, please, go to www.checkrare.com

Nizar Mahlaoui, MD, MPH, PhD - Simplifying Patient-Integrated Care for Those Requiring Immunoglobulin Therapy: Making Smart Moves with Automated and Digital Technology

Nizar Mahlaoui, MD, MPH, PhD - Simplifying Patient-Integrated Care for Those Requiring Immunoglobulin Therapy: Making Smart Moves with Automated and Digital Technology

Nizar Mahlaoui, MD, MPH, PhD - Simplifying Patient-Integrated Care for Those Requiring Immunoglobulin Therapy: Making Smart Moves with Automated and Digital Technology

Nizar Mahlaoui, MD, MPH, PhD - Simplifying Patient-Integrated Care for Those Requiring Immunoglobulin Therapy: Making Smart Moves with Automated and Digital Technology

Nizar Mahlaoui, MD, MPH, PhD - Simplifying Patient-Integrated Care for Those Requiring Immunoglobulin Therapy: Making Smart Moves with Automated and Digital Technology

WARNING FOR PARENTS: In this episode, we talk about sex, so this would be a good one to listen to when your children are not in the car. SPOUSES: If you are married, we recommend listening to this episode WITH YOUR SPOUSE. If they are not with you, pause it and plan a time to listen together. In this episode, we talk about so many of the benefits of sexual intimacy in marriage. We talked about some of the hormones that are responsible for all of these benefits and wanted to share the notes on this for your reference: Endorphins: Endorphins released during orgasm actually mimic morphine Oxytocin: Known as the “love hormone” is released during an orgasm  Also released during labor and breastfeeding - it bonds a mother to her baby.   Causes feelings of attachment and trust Immunoglobulin a (IgA): These antibodies help combat disease and keep bodies safe from colds and flu Testosterone and Estrogen: Can keep the body looking young and vital   Neurotransmitters: Dopamine - related to how we feel pleasure and motivates our brains to feel that pleasure again  Seratonin - regulates mood, social behaviors, emotions, appetite, and digestion, sleep, memory, and sex drive.  Epinephrine: An adrenaline hormone which activates your sympathetic nervous system giving you feelings of exhilaration.   Nitric Oxide: Minimizes symptoms of depression and anxiety

Dr. Vera Bril discusses her paper, "Randomized Double-Blind Placebo-Controlled Trial of the Corticosteroid-Sparing Effects of Immunoglobulin in Myasthenia Gravis".  Show references: https://doi.org/10.1212/WNL.0000000000201501

Dr. Gordon Smith talks with Dr. Vera Bril about exploring the potential use of immunoglobulin as a corticosteroid-sparing agent in patients with Myasthenia Gravis.  Read the related article in Neurology.

Nathan is 47 years old, married, and a father of 3. A decent high school athlete, he was always a hard gainer. He was a lightly recruited basketball player in TX but started gaining muscle weight when he went to college. He dropped out after some financial issues during his senior year and joined the Army in 1999. After learning Arabic, he got to Ft. Bragg just before 9/11 and spent the next 8 years going back and forth to Afghanistan and Iraq as a member of Delta Force. He left the Army in 2010, finished college, took a couple of MMA fights, and then served 5 years as an operative in the US Intelligence community. He left that in 2015 and has owned a couple of consulting businesses and done government-related Independent Contracting since then. He does some health and wellness coaching on the side. He has always worked out, stayed fit, and he was a stand-out "military athlete." He ate whatever he wanted, and stayed "fit" but dealt with injuries and "aging" related issues. Adult acne, radial neuropathy, premature balding, skin tags, signs of inflammation (gingivitis, tinnitus, plantar fasciitis, etc.). He found keto in 2016 and was blown away. He went carnivore in 2019 and was even further blown away. He was intensely sick and didn't know it until he had the benefit of hindsight with zero-carb. In August 2022, he developed Gullian-Barre Syndrome. They told him he'd be an inpatient for 6-8 weeks, do inpatient physical therapy for 3-4 months, and then do outpatient physical therapy for however long it took to regain the movement, feeling, strength, and endurance that he'd lost (assuming he ever regained it). He walked out of the hospital 2 weeks after he entered under his own power. He went to his first outpatient PT appointment the next day and the doctor told him not to come back because he couldn't do anything for him. It took a few weeks for some residual numbness to disappear, but he feels back to new. Some people think his diet put him in the hospital, but he knows his diet got him out faster than anyone on his treatment team could fathom. Timestamps: 00:00 Trailer 00:47 Introduction 03:08 Intensely sick, brainfog, ADHD 05:36 Guillain-Barre syndrome diagnosis 08:26 Guillain-Barre syndrome causes 10:08 Guillain-Barre syndrome progression 13:05 Lumbar puncture to diagnose Guillain-Barre syndrome 14:06 Immunoglobulin therapy 16:23 Making full recovery 18:32 Hospital food 20:41 Guillain-Barre prognosis 22:55 No residual symptoms 26:05 Outpatient neurologist's opinion: “abnormal case of Guillain-Barre” 27:45 Other things that improved on the carnivore diet 30:47 On the ketogenic diet 32:33 Current diet with family 36:25 LDL and old people's health 38:22 Obesity in children 40:34 ACL injuries in children 43:32 Demonizing red meat 45:00 Peak performance and meat 49:23 Closing See open positions at Revero: https://jobs.lever.co/Revero/ Join Carnivore Diet for a free 30 day trial: https://carnivore.diet/join/ Book a Carnivore Coach: https://carnivore.diet/book-a-coach/ Carnivore Shirts: https://merch.carnivore.diet Subscribe to our Newsletter: https://carnivore.diet/subscribe/ . ‪#revero #shawnbaker #Carnivorediet #MeatHeals #HealthCreation   #humanfood #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree  ‪

Paul shares the results from his August Bloodwork panel from Marek Health. He does a deep dive into Testosterone, Immunoglobulin, Boron, Genistein, Isoflavonoids and touches on TMAO, Uric acid, and GGT. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn't helping people lead better lives. Now that I've realized this, I've become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you'll join me on this journey. Time Stamps: 00:09:43 Podcast begins 00:12:08 Paul's lipid panel  00:14:48 Is elevated LDL a risk factor for heart disease? 00:24:08 Paul's Plasma, Ammonia results 00:25:28 Paul's Anemia profile 00:32:08 Paul's Blood Count profile 00:34:08 Paul's Thyroid panel 00:36:53 Comprehensive metabolic panel 00:38:13 Paul's Urinalysis 00:40:13 Paul's hormones 00:42:53 Insulin sensitivity  00:47:30 Boron 00:59:58 How to optimize your testosterone and increase androgen receptors 01:03:18 The detriments of consuming soy 01:05:43 Paul's thoughts on TMAO 01:09:40 Paul reviews the remainder of his bloodwork Sponsors: Heart & Soil: www.heartandsoil.co Sign up for Animal Based Gathering 2023: animalbasedgathering.com  Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org   Marek Health: marekhealth.com/fundamentalhealth, use code PAUL for 10% off your first lab order Primal Pastures: www.primalpastures.com, use code CarnivoreMD for 10% off your first order Eight Sleep: www.eightsleep.com/carnivoremd for exclusive Labor Day Savings through 9/11 and to get $150 off your order White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders

M. Elizabeth Younger, CRNP, PhD, Assistant Professor of Pediatrics at Johns Hopkins University School of Medicine joined us at a recent IDF forum to discuss immunoglobulin replacement therapy and the various ways it can be tweaked to fit each patient's unique needs. The information, terminology, and opinions presented in this forum do not necessarily reflect the views of IDF, its Board of Trustees, sponsors, or donors. To view the slideshow used in the presentation, click here: https://primaryimmune.org/sites/default/files/4-For%20Website-IDF%20Forum-Ig%20Therapy-FINAL-5.19.22.pdf Thank you to Takeda, CSL Behring, Grifols, and Accredo for sponsoring this event.

Dr. Rae Bacharach discusses the Neurology Today article, "Maintenance Intravenous Immunoglobulin Prevents Relapse in Adult Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease". Show references: https://journals.lww.com/neurotodayonline/Fulltext/2022/05190/Maintenance_Intravenous_Immunoglobulin_Prevents.1.aspx

"Is Intravenous Immunoglobulin Therapy for Chronic Pain Conditions an Underused Treatment Option?" by Nirguna Thalla, MD, MBA, Resident, MedStar Georgetown University, Washington, DC; Keith Newton, MD, Resident, University of Central Florida College of Medicine, Orlando, Florida; and Dalia Elmofty, MD, Associate Professor, University of Chicago Medicine, Chicago, Illinois. From ASRA Pain Medicine News, February 2022. See original article at www.asra.com/asra-news for figures and references. This material is copyrighted.   

Join 3 experts in discussion about how to best identify patients at high-risk of progression and the role of proteinuria in IgA nephropathy management. Credit available for this activity expires: 4/4/2023 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/971060?src=mkm_podcast_addon_971060

Cardiac amyloidosis is an often overlooked and thus misdiagnosed form of a restrictive cardiomyopathy in which delayed diagnosis is associated with significant morbidity and mortality. Immunoglobulin light chain (AL) cardiac amyloidosis is the most deadly from of cardiac amyloidosis but significant progress has been made in treatment with the first FDA approved therapy for this condition - daratumumab. In this interview, Mathew Maurer, MD and Stephen J. Nicholls, MBBS, PhD, FACC, with Yuvraj Chowdhury, MD, discuss Pathophysiology and Therapeutic Approaches to Cardiac Amyloidosis--Focus on AL.

This episode will explore killer cell immunoglobulin-like receptor (KIR) testing in solid organ and hematopoietic cell transplantation with experts Drs. Paula Arnold and Luis Hidalgo. We will explore recent literature on KIR utility in clinical decision-making.

Looking for nutrient-based products that are shown to support the immune system, gi system, and more? Learn about some of the most research-backed products in the industry on episode 21 of the Fredrickson Health Show 0:00 Intro 0:41 Guest Intro (Brian Kaufman) 2:25 Topic intro (Gut health) 3:22 Medical Food vs Supplement 4:00 What is medical food? 5:52 How did Brian get to this world of nutrition? 10:34 Meet Rodney 12:41 What makes gut health so important 14:04 Immunoglobulin (im-yeh-no-GLOB-yeh-len) 17:29 Immunoglobulin in oral form 20:14 Mechanism of action for oral IGG 22:29 What does Immunoglobulin bind to? 26:39 Immunoglobulin Analogy 28:39 How to know that it's not binding to the good bacteria in our body 29:51 True to life Immunoglobulin experience 31:57 Brian's health journey 35:03 AHA! Moments 37:05 Gut health to brain health connection 40:20 Immunoglobulin impact on athletes 45:24 New clinical studies to be excited for 49:34 Should everyone take SBI protect? 50:32 Immunoglobulin on kids 53:20 How / When can you take it? 53:58 The Billboard Question 55:13 What health-related tool would you bring on a deserted island? 59:48 Where to connect with Brian Kaufman Follow me! Instagram: Dr.Robert Fredrickson Instagram Business: FredricksonHealthSolutions TikTok: FredricksonHealth Facebook: FredricksonHealthSolutions Social Media Stream Page-https://beacons.page/fredricksonhealth Disclaimer: Also consult with a physician before starting a new rehab exercise, training routine, diet, or dietary supplement. This video is for educational purposes only. Always ask your doctor or physcian for personalized medical advice.

This episode covers immunodeficiency caused by disorders of B cells and immunoglobulins.Written notes can be found at https://zerotofinals.com/paediatrics/immunology/igdisorders/ or in the immunology section of the Zero to Finals paediatrics book.The audio in the episode was expertly edited by Harry Watchman.

This episode covers immunoglobulin epitopes!

This episode covers immunoglobulin isotypes!

Dr. Speelziek interviews Dr. Kurt Kimpinski and Dr. Luciano Sposato on their article, Subcutaneous versus intravenous immunoglobulin for chronic autoimmune neuropathies. A meta-analysis. High-dose intravenous immunoglobulin (IVIg) is an evidence-based treatment for multifocal motor neuropathy (MMN) and chronic inflammatory demyelinating polyneuropathy (CIDP). Recently, subcutaneous immunoglobulin (SC-Ig) has received increasing attention. The authors performed a meta-analysis of reports of efficacy and safety of SC-Ig versus IVIg for inflammatory demyelinating polyneuropathies.The efficacy of SC-Ig is similar to IVIg for CIDP and MMN and has a significant safety profile. Muscle Nerve 55: 802-809, 2017.

Do patients with 1st trimester bleeding need to get anti-D immunoglobulin if they're Rh negative? We dive into the topic this week. https://media.blubrry.com/coreem/content.blubrry.com/coreem/Podcast_86_0_Final_Cut.m4a Download Leave a Comment Tags: Early Pregnancy, Obstetrics, RhoGam, Vaginal Bleeding Show Notes Take Home Points An Rh negative woman can become alloimmunized to Rh antigen if exposed to blood from an Rh positive fetus. Theoretically, this alloimmunization can occur even in early pregnancy While anti-D immune globulin has clearly been shown to be beneficial in preventing alloimmunization in 2nd and 3rd trimester pregnancy, there is no evidence supporting use specifically in the 1st trimester Despite the absence of evidence, RhoGam administration has become routine in many places. At this time, it's advisable to follow local practice patterns regarding which patients should be given RhoGam. References ACOG Practice Bulletin. Prevention of Rh D Alloimmunization. Int J Gynaecol Obstet 1999; 66(1): 63-70. PMID: 10458556 Recommendations reaffirmed in 2016 Hahn SA et al. Clinical Policy: Critical Issues in the Initial Ealuation and Management of Patients Presenting to the Emergency Department in E...