Podcasts about clustered

Clustered regularly interspaced short palindromic repeats (CRISPR-Cas12a), discovered a few years ago, is a method that detects even small levels of pathogens.Professor Kevin J Zwezdaryk and researchers at the Tulane University School of Medicine, USA, are working on a cost-effective, CRISPR-Cas12a-based pathogen detection tool aiming to upgrade patient care. Read more in Research Features Read the original research: doi.org/10.1016/j.bmt.2023.03.004

Author Paige L. Sweet discusses the article, "Clustered Vulnerabilities: The Unequal Effects of COVID-19 on Domestic Violence," published in the June 2024 issue of American Sociological Review.

WMPO recap: (2:30)Genesis Preview: (15:43)Sun Day Red first impressions: (27:08)Clustered 2v2: (30:01)

Hybrid Puzzle: The audio will tell you where each of the pieces on the board are, then read a series of moves from that position. When prompted, try to identify the best next move. To learn more about Don't Move Until You See It and get the free 5-day Conceptualizing Chess Series, head over to https://dontmoveuntilyousee.it/conceptualization FEN for today's exercise: 3r4/8/8/5k2/P6R/4p3/2KbB3/8 w - - 0 1 PGN for today's exercise: 1. Rh5+ Kf4 2. Rh4+ Kg3 3. Rg4+ Kf2 4. Bd1 Rc8+ 5. Kd3 Rc1 6. Be2 * And the answer is... Rc3+ 7. Ke4 Kxe2 *

Makeup blablabla to sort my clustered mind --- Support this podcast: https://podcasters.spotify.com/pod/show/haiying-yang/support

Geologists in the field climb hills and hang onto craggy outcrops; they put their fingers in sand and scratch, smell, and even taste rocks. Beginning in 2004, however, a team of geologists and other planetary scientists did field science in a dark room in Pasadena, exploring Mars from NASA's Jet Propulsion Laboratory (JPL) by means of the remotely operated Mars Exploration Rovers (MER). Clustered around monitors, living on Mars time, painstakingly plotting each movement of the rovers and their tools, sensors, and cameras, these scientists reported that they felt as if they were on Mars themselves, doing field science. The MER created a virtual experience of being on Mars. In Working on Mars, William Clancey examines how the MER has changed the nature of planetary field science. Drawing on his extensive observations of scientists in the field and at the JPL, Clancey investigates how the design of the rover mission enables field science on Mars, explaining how the scientists and rover engineers manipulate the vehicle and why the programmable tools and analytic instruments work so well for them. He shows how the scientists felt not as if they were issuing commands to a machine but rather as if they were working on the red planet, riding together in the rover on a voyage of discovery. William J. Clancey is Chief Scientist of Human-Centered Computing in the Intelligent Systems Division at NASA Ames Research Center, and Senior Research Scientist at the Florida Institute for Human and Machine Cognition. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science-technology-and-society

Geologists in the field climb hills and hang onto craggy outcrops; they put their fingers in sand and scratch, smell, and even taste rocks. Beginning in 2004, however, a team of geologists and other planetary scientists did field science in a dark room in Pasadena, exploring Mars from NASA's Jet Propulsion Laboratory (JPL) by means of the remotely operated Mars Exploration Rovers (MER). Clustered around monitors, living on Mars time, painstakingly plotting each movement of the rovers and their tools, sensors, and cameras, these scientists reported that they felt as if they were on Mars themselves, doing field science. The MER created a virtual experience of being on Mars. In Working on Mars, William Clancey examines how the MER has changed the nature of planetary field science. Drawing on his extensive observations of scientists in the field and at the JPL, Clancey investigates how the design of the rover mission enables field science on Mars, explaining how the scientists and rover engineers manipulate the vehicle and why the programmable tools and analytic instruments work so well for them. He shows how the scientists felt not as if they were issuing commands to a machine but rather as if they were working on the red planet, riding together in the rover on a voyage of discovery. William J. Clancey is Chief Scientist of Human-Centered Computing in the Intelligent Systems Division at NASA Ames Research Center, and Senior Research Scientist at the Florida Institute for Human and Machine Cognition. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Geologists in the field climb hills and hang onto craggy outcrops; they put their fingers in sand and scratch, smell, and even taste rocks. Beginning in 2004, however, a team of geologists and other planetary scientists did field science in a dark room in Pasadena, exploring Mars from NASA's Jet Propulsion Laboratory (JPL) by means of the remotely operated Mars Exploration Rovers (MER). Clustered around monitors, living on Mars time, painstakingly plotting each movement of the rovers and their tools, sensors, and cameras, these scientists reported that they felt as if they were on Mars themselves, doing field science. The MER created a virtual experience of being on Mars. In Working on Mars, William Clancey examines how the MER has changed the nature of planetary field science. Drawing on his extensive observations of scientists in the field and at the JPL, Clancey investigates how the design of the rover mission enables field science on Mars, explaining how the scientists and rover engineers manipulate the vehicle and why the programmable tools and analytic instruments work so well for them. He shows how the scientists felt not as if they were issuing commands to a machine but rather as if they were working on the red planet, riding together in the rover on a voyage of discovery. William J. Clancey is Chief Scientist of Human-Centered Computing in the Intelligent Systems Division at NASA Ames Research Center, and Senior Research Scientist at the Florida Institute for Human and Machine Cognition. Learn more about your ad choices. Visit megaphone.fm/adchoices

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.08.01.551420v1?rss=1 Authors: Amoiridis, M., Meaburn, K., Verigos, J., Gittens, W. H., Ye, T., Neale, M. J., Soutoglou, E. Abstract: DNA replication and transcription generate DNA supercoiling, which can cause topological stress and intertwining of daughter chromatin fibers, posing challenges to the completion of DNA replication and chromosome segregation. Type II topoisomerases (Top2s) are enzymes that relieve DNA supercoiling and decatenate braided sister chromatids. How Top2 complexes deal with the topological challenges in different chromatin contexts, and whether all chromosomal contexts are subjected equally to torsional stress and require Top2 activity is unknown. Here we show that catalytic inhibition of the Top2 complex in interphase has a profound effect on the stability of heterochromatin and repetitive DNA elements. Mechanistically, we find that catalytically inactive Top2 is trapped around heterochromatin leading to DNA breaks and unresolved catenates, which necessitate the recruitment of the structure specific endonuclease, Ercc1-XPF, in an Slx4- and SUMO-dependent manner. Our data are consistent with a model in which Top2 complex resolves not only catenates between sister chromatids but also inter-chromosomal catenates between clustered repetitive elements. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Ever found yourself pondering the intricate connection between our emotional and intellectual response to faith? That's exactly what we're unpacking in our latest chat. Clustered around the proverbial kitchen table, we send out warm wishes to Caitlin and Remington, soon to tie the knot, and tumble down memory lane, reliving those childhood summers spent cherry picking. We also share some snippets from our week, including Daniel's intriguing conversation, Zeke's podcast endeavors, and a particularly gripping debate over two-color cheese.We then transition to the meatier part of our dialogue, dissecting the concept of mourning in relation to the poor in spirit. How does this tie into the emotional and intellectual aspects of faith? We turn to John 20:29 and Isaiah 61:1-3 for an insightful peek into the biblical definition of faith and the liberating sensation of freeing those poor in spirit from the shackles of sin. The journey doesn't stop there. We delve deeper, exploring the symbolic layers hidden in Isaiah's ashes, which represent the ancient posture of mourning and the inner turmoil of grief.As we approach the end, we contemplate the beautiful transformation from ashes to a headdress, oil of gladness, and a garment of praise. This change symbolizes joy, happiness, and thankfulness, hallmarks of the freedom and liberty offered through Christ. It's a stunning culmination that ties the intellectual and emotional aspects of faith together, providing a comprehensive definition of religion. As we wrap up, we express our sincere gratitude to you, our listeners, and invite you to join us in this meaningful discourse. Shoot us your thoughts, questions, or feedback, and remember to keep the faith. Have a blessed day!Support the showSupport our ministryCheck us out at purefaithliving.comContact us at purefaithliving.com/contactFollow us on twitter @purefaithlivingFollow us on Facebook at Pure Faith Podcast

Travelers recap: (1:50)Rocket Mortgage preview: (23:00)KPMG Womens PGA recap: (28:25)Rattlewood 2v2: (31:38)Clustered with Jack: (39:33)---------------Follow us on instagram! https://www.instagram.com/bigplayersonlypod/

The Big Players talk tour golf, starting with the Charles Schwab Challenge which saw Emiliano Grillo get back into the winner's circle, and The Memorial coming up this week at Jack's place (2:20). To close out the episode the guys talk about the 2v2 at Clustered, Tippy's round at the Links at Gettysburg, Ken @ Camden, and the celebratory bash for Ben and Tully's win at Dubb's house (23:52).

Fundamentals of Database Engineering udemy course (link redirects to udemy with coupon) https://database.husseinnasser.com In version 5.3, MongoDB introduced a feature called clustered collection which stores documents in the _id index as oppose to the hidden wiredTiger hidden index. This eliminates an entire b+tree seek for reads using the _id index and also removes the additional write to the hidden index speeding both reads and writes.  However like we know in software engineering, everything has a cost. This feature does come with a few that one must be aware of before using it. In this video I discuss the following  How Original MongoDB Collections Work How Clustered Collections Work Benefits of Clustered Collections Limitations of Clustered Collections  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.14.536980v1?rss=1 Authors: Hoshino, N., Kanadome, T., Itoh, M., Kaneko, R., Inoue, Y. U., Inoue, T., Hirabayashi, T., Watanabe, M., Takeharu, N., Tarusawa, E., Yagi, T. Abstract: Clustered protocadherin (Pcdh) functions as a cell recognition molecule through the homophilic interaction in CNS. However, its interactions have yet not been visualized in neurons. We previously reported Pcdh{gamma}B2-FRET probes to be applicable only for cell lines. Herein, we newly designed Pcdh{gamma}B2-FRET probes by fusing FRET donor and acceptor fluorescent proteins to a single Pcdh{gamma}B2 molecule and succeeded in visualizing Pcdh{gamma}B2 homophilic interaction in cultured hippocampal neurons. The {gamma}B2-FRET probe localized in the soma and neurites, and FRET signals were observed at contact sites between neurites and eliminated by EGTA addition. Live imaging revealed that the FRET-negative {gamma}B2 signals were rapidly moving along neurites and soma, whereas the FRET-positive signals remained in place. We observed that the {gamma}B2 proteins at synapses rarely interact homophilically. The {gamma}B2-FRET probe would allow us to elucidate the function of the homophilic interaction and the cell recognition mechanism. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.15.536995v1?rss=1 Authors: Tarusawa, E., Hasegawa, S., Noda, D., Kawamura, N., Fukazawa, Y., Watanabe, M., Hirabayashi, T., Yagi, T. Abstract: Clustered protocadherins (cPcdhs) are candidates for the neural circuit formation; however, the localization of cPcdhs in pre- and post-synaptic compartments has not been well characterized. Here we examined the localization of cPcdh{gamma} proteins in the mouse hippocampal CA1 region using light and electron microscopy. From postnatal day 7 to 21, cPcdh{gamma} immunosignals were detected in approximately 40-60% of spines of pyramidal cells. SDS-digested freeze-fracture replica labelling revealed that cPcdh{gamma} immunolabeling was found in 50% of PSD 95-positive postsynaptic profiles but only in less than 10% of vGluT1-positive pre-synaptic terminals. Interestingly, cPcdh{gamma}-positive pre-synaptic terminal was exclusively accompanied by cPcdh{gamma}-positive postsynaptic counterpart. In addition, electrophysiological investigations revealed that the miniature excitatory postsynaptic current frequency in cPcdh{gamma} cKO mice was significantly higher than that in wild-type mice. These results suggest that cPcdh{gamma} proteins are unequally distributed in the pre- and post-synaptic membrane during neural circuit development and regulate the number of excitatory synapses. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.02.530772v1?rss=1 Authors: Leighton, A. H., Cheyne, J. E., Lohmann, C. Abstract: Synaptic inputs to cortical neurons are highly structured in adult sensory systems, such that neighboring synapses along dendrites are activated by similar stimuli. This organization of synaptic inputs, called synaptic clustering, is required for high-fidelity signal processing, and clustered synapses can already be observed before eye opening. However, how clustered inputs emerge during development is unknown. Here, we employed concurrent in vivo whole-cell patch clamp and dendritic calcium imaging to map spontaneous synaptic inputs to dendrites of layer 2/3 neurons in the mouse primary visual cortex during the second postnatal week until eye opening. We find that the number of functional synapses and the frequency of transmission events increase several fold during this developmental period. At the beginning of the second postnatal week, synapses assemble specifically in confined dendritic segments, whereas other segments are devoid of synapses. By the end of the second postnatal week, just before eye-opening, dendrites are almost entirely covered by domains of co-active synapses. Finally, co-activity with their neighbor synapses correlates with synaptic stabilization and potentiation. Thus, clustered synapses form in distinct functional domains presumably to equip dendrites with computational modules for high-capacity sensory processing when the eyes open. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.03.526887v1?rss=1 Authors: Mancia Leon, W. R., Steffen, D. M., Dale-Huang, F., Rakela, B., Breevoort, A., Romero-Rodriguez, R., Hasenstaub, A. R., Stryker, M. P., Weiner, J. A., Alvarez-Buylla, A. Abstract: Cortical function critically depends on inhibitory/excitatory balance. Cortical inhibitory interneurons (cINs) are born in the ventral forebrain and migrate into cortex, where their numbers are adjusted by programmed cell death. Previously, we showed that loss of clustered gamma protocadherins (Pcdh{gamma}), but not of genes in the alpha or beta clusters, increased dramatically cIN BAX-dependent cell death in mice. Here we show that the sole deletion of the Pcdh{gamma}c4 isoform, but not of the other 21 isoforms in the Pcdh{gamma} gene cluster, increased cIN cell death in mice during the normal period of programmed cell death. Viral expression of the Pcdh{gamma}c4 isoform rescued transplanted cINs lacking Pcdh{gamma} from cell death. We conclude that Pcdh{gamma}, specifically Pcdh{gamma}c4, plays a critical role in regulating the survival of cINs during their normal period of cell death. This demonstrates a novel specificity in the role of Pcdh{gamma} isoforms in cortical development. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this week's Podcast: We began our Oxalic Acid Winter treatments this week, the first batch of many. Our bees had their first taste of wintery weather and were Clustered together, stay tuned to find out why.Hi, I'm Stewart Spinks and welcome to Episode 237 of my podcast, Beekeeping Short and Sweet.Sponsorship: I'm delighted to say that our podcast is now sponsored in part by Simon The Beekeeper - 'Making beekeeping an affordable hobby for everyone, Simon the Beekeeper provides the best value beekeeping equipment possible, along with a super-fast delivery service. The bees won't wait, so their customers don't have to either.Visit the website at www.simonthebeekeeper.co.ukContact Me at The Norfolk Honey CompanyJoin Our Beekeeping Community in the following ways:Early Release & Additional Video and Podcast Content - Access HereStewart's Beekeeping Basics Facebook Private Group - Click HereTwitter - @NorfolkHoneyCo - Check Out Our FeedInstagram - @norfolkhoneyco - View Our Great PhotographsSign Up for my email updates by visiting my website here

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.14.520428v1?rss=1 Authors: Ellis, C. A., Miller, R. L., Calhoun, V. D. Abstract: Identifying subtypes of neuropsychiatric disorders based on characteristics of their brain activity has tremendous potential to contribute to a better understanding of those disorders and to the development of new diagnostic and personalized treatment approaches. Many studies focused on neuropsychiatric disorders examine the interaction of brain networks over time using dynamic functional network connectivity (dFNC) extracted from resting-state functional magnetic resonance imaging data. Some of these studies involve the use of either deep learning classifiers or traditional clustering approaches, but usually not both. In this study, we present a novel approach for subtyping individuals with neuropsychiatric disorders within the context of schizophrenia (SZ). We train an explainable deep learning classifier to differentiate between dFNC data from individuals with SZ and controls, obtaining a test accuracy of 79%. We next make use of cross-validation to obtain robust average explanations for SZ training participants across folds, identifying 5 SZ subtypes that each differ from controls in a distinct manner and that have different degrees of symptom severity. These subtypes specifically differ from one another in their interaction between the visual network and the subcortical, sensorimotor, and auditory networks and between the cerebellar network and the cognitive control and subcortical networks. Additionally, there are statistically significant differences in negative symptom scores between the subtypes. It is our hope that the proposed novel subtyping approach will contribute to the improved understanding and characterization of SZ and other neuropsychiatric disorders. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

An airhacks.fm conversation with Lenny Primak (@lprimak) about: previous appearance of lenny on airhacks: "#137 (fake) reactive programming, project loom, chunked IO", the airhacks.tv show, captains and first officers, Payara's Clustered Singleton EJB singletons and clusters, JBoss HA-Singleton, Paxos algorithm, JSR-223, Hazelcast partitioning, hazelcast metrics, hazelcast's DataSerializable, Apache Shiro commitment, Benjamin Marwell as guest on "#181 Java Authentication and Authorization with Apache Shiro", Apache Tapestry ships with own dependency injection framework, Securing Web Applications with Apache Shiro, Cesna Citation CJ4, Lenny Primak on twitter: @lprimak

Ruling out Initially Clustered Primordial Black Holes as Dark Matter by V. De Luca et al. on Tuesday 18 October Combining constraints from microlensing and Lyman-$alpha$ forest, we provide a simple argument to show that large spatial clustering of stellar-mass primordial black holes at the time of formation, such as the one induced by the presence of large non-Gaussianities, is ruled out. Therefore, it is not possible to evade existing constraints preventing stellar-mass primordial black holes to be a dominant constituent of the dark matter by boosting their initial clustering. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2208.01683v2

Ruling out Initially Clustered Primordial Black Holes as Dark Matter by V. De Luca et al. on Tuesday 18 October Combining constraints from microlensing and Lyman-$alpha$ forest, we provide a simple argument to show that large spatial clustering of stellar-mass primordial black holes at the time of formation, such as the one induced by the presence of large non-Gaussianities, is ruled out. Therefore, it is not possible to evade existing constraints preventing stellar-mass primordial black holes to be a dominant constituent of the dark matter by boosting their initial clustering. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2208.01683v2

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.20.508805v1?rss=1 Authors: Chehade, N. G., Gharbawie, O. Abstract: Motor (M1) and dorsal premotor (PMd) cortex are central to arm and hand control in primates. Motor outputs in both areas confer somatotopically organized arm and hand zones. Here, we investigate the spatial mapping between those motor zones and movement-related neural activity to gain insight about functional organization in M1/PMd. Two macaques reached and grasped while cortical activity was measured with intrinsic signal optical imaging. Activity maps were quantified in relation to microstimulation motor maps from the same hemispheres. Each activity map was comprised of many patches and overlapped surprisingly small portions of the motor map. Functional differences between the patches were inferred from their activity time courses and location within the motor map. We propose that M1/PMd contain subzones that are preferentially tuned for specific actions. Thus, the spatial dimension of neural activity in frontal motor areas is an important organizing principle of the neural code for movement control. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Oman's Indian embassy Twitter account compromised to promote XRP scamWell-known vulnerability in private keys likely exploited in $160M Wintermute hackSEC Claims Jurisdiction Since ETH Nodes are Clustered in the U.S.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.24.505057v1?rss=1 Authors: Noguchi, J., Watanabe, S., Oga, T., Isoda, R., Nakagaki, K., Sakai, K., Sumida, K., Hoshino, K., Saito, K., Miyawaki, I., Sugano, E., Tomita, H., Mizukami, H., Watakabe, A., Yamamori, T., Ichinohe, N. Abstract: Impairments in the experience-dependent elaboration of neural circuits are assumed to underlie autism spectrum disorder (ASD). However, the phenotype underlying synaptic plasticity is poorly understood. Here, we used a valproic acid-induced ASD marmoset model and in vivo two-photon microscopy to investigate the structural dynamics of dendritic spines in the dorsomedial prefrontal cortex, which is involved in ASD core symptoms. In model marmosets compared to controls, spine turnover was upregulated and spines were actively generated in clusters. Clustered emerging spines were predominant in carryover of generated spines in the model marmosets. Presynaptic boutons of local axons, but not long-range commissural axons, showed hyperdynamic turnover. Furthermore, nasal oxytocin administration reduced the clustered emergence of spines. Finally, we confirmed the high molecular conformity of adult animal models with human ASD. Our study suggests that an altered balance between synaptic plasticity and consolidation underlies ASD, and may be a potential therapeutic target. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Thank you for tuning into another episode of HOLI SACRED SH*T! You can listen to all of our conscious conversations on many different topics of awakening + healing over at our mother podcast, MEDICINE HUMAN . Here is another wonderful + informative instagram live conversation from earlier this spring. I hope this conversation shifts the way you innerstand water and the ways we use it and are made of it. I've got new episodes and content coming your way next week! I've been working hard and well behind the scenes for months to bring forth important pathways to assist in ascension and healing. We start fresh with SEASON 5 next week. Watch this episode on youtube here. LOVE LOVE LOVE YOU ALL. Ivy Subscribe to our YouTube Channel Join Our Next Community Learning Lounge Book Your Healing Blueprint Consultation Learn How Medical Grade Living Water Will Change Your Life Visit Our Website For So Much More Goodness CONNECT WITH IVY + MEDICINE HUMAN: Email: ivy@medicinehuman.com Instagram: @medicinewomanivy @medicinalhuman Telegram: @medicinewomanivy TruthSocial: @medicinewomanivy Linkedin: @medicinewomanivy Disclaimer: This podcast and the words, conversations, guests, and resources shared are intended to support, encourage, inform and expand thinking to increase self responsibility. Nothing created or shared here is ever intended to diagnose, prescribe, treat or cure. Everyone's health is their own responsibility, and everyone is empowered to exercise wise discernment, educate themselves, ask amazing questions, seek accurate information and practice informed consent. Always seek a health professional that you trust when you need to. Your body. Your mind. Your soul. Your choice. Your consent. Your authority. You are God, you are Sovereign, you are Free. And so it is.

Hi Everyone! Here is another wonderful + informative instagram live conversation from earlier this spring. I hope this conversation shifts the way you innerstand water and the ways we use it and are made of it. I've got new episodes and content coming your way next week! I've been working hard and well behind the scenes for months to bring forth important pathways to assist in ascension and healing. We start fresh with SEASON 5 next week. Watch this episode on youtube here.Thank you for tuning into another episode of MEDICINE HUMAN! You can listen to all of our health and cleansing related episodes in one easy spot over at HOLI SACRED SH*T . We've built this as a sub-podcast to MEDICINE HUMAN to keep all the holistic healing resource episodes organized for you and easy to find and share! Tremendous love to you, dear frens + friends. In Love, Ivy. Subscribe to my YouTube Channel Book Your Healing Blueprint Consultation Join Our Next Community Learning Lounge Learn How Medical Grade Living Water Will Change Your Life Visit Our Website For So Much More Goodness - CONNECT WITH IVY + MEDICINE HUMAN: Email: ivy@medicinehuman.com Instagram: @medicinewomanivy @medicinalhuman Telegram: @medicinewomanivy TruthSocial: @medicinewomanivy Linkedin: @medicinewomanivy We are a holistic ministry (Inspired Sovereignty Ministries South), and we graciously accept donations via venmo @medicinewomanivy - Disclaimer: This podcast and the words, conversations, guests, and resources shared are intended to support, encourage, inform and expand thinking to increase self responsibility. Nothing created or shared here is ever intended to diagnose, prescribe, treat or cure. Everyone's health is their own responsibility, and everyone is empowered to exercise wise discernment, educate themselves, ask amazing questions, seek accurate information and practice informed consent. Always seek a health professional that you trust when you need to. Your body. Your mind. Your soul. Your choice. Your consent. Your authority. You are God, you are Sovereign, you are Free. And so it is. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/medicinehuman/message Support this podcast: https://anchor.fm/medicinehuman/support

On one day soon within the coming months, there will be 8 billion of we humans on this planet. Clustered across nearly 200 different nations we will all be hustling and bustling away, to survive in a world that is beset by uncertainties and complex social, economic, cultural, and ecological challenges. Given that most of these challenges have truly global dimensions, how do we rise above our own national concerns? Who will help us think and act beyond our borders? Who are our international guardians and carers?  Michael Sackett happens to be one of them and in and in his conversation with our host Richard Bawden, he shares his experiences and insights.  For more than two decades, Michael worked in increasingly senior positions with the United Nations organisation, particular within the World Food Program and in the latter part of his career, in Humanitarian initiatives mostly in Africa and Asia.

Educational technology has been on the rise for the last 15 years. Yet, completion rates of online courses range between 5% and 15%. Online learning seems to lack powerful engagement mechanisms and impact in students' lives. EdTech companies also receive a very modest portion of the global venture capital pie compared to startups in other market segments.  For a deep-dive into the world of online learning, I invited Rotem Carmely. Rotem is an EdTech founder with a passion for building engaging communities.  Topics we explore:  Vulnerability and success porn: Why is it hard to learn from success stories? Pitfalls of online learning and how they influence our career development. Online education as a business: a collision of quick scalability and impact.  The new type of investors we need for educational technology. Failing as a part of the process and other founder's learnings.  About Rotem Carmely:  Rotem is the co-founder and CEO of Clustered, a startup on a mission to make learning as social as possible. Clustered offers instructors an all-in-1 platform to create and scale outstanding group-based courses. Rotem is also a Transcend Fellow. Transcend Fellowship is a highly selective programme for founders building the future of learning and work.  About Darya Kamkalova:  Darya is many things: a podcaster, a co-founder of Manifest Taproom (a craft beer bar in Berlin), an investor, a startup evaluator, and a data industry professional. In the last 10 years, she has been driving or supporting various projects empowering women. Darya is based in Berlin 

NASA released a video of a group of polar storms on Jupiter forming an octagonal shape and resembling pepperoni on pizza in an infrared image. ThePrint's Sandhya Ramesh explains how storms on Jupiter work and how they cluster at the two poles. Subscribe to the Pure Science Telegram Channel https://t.me/PureScienceWithSandhyaRamesh Supplementary reading: Pepperoni storms video https://www.instagram.com/p/CZx420aDKRM/ Imagine 34 Mount Everests stacked together — that's the depth of Jupiter's Great Red Spot https://theprint.in/science/imagine-34-mount-everests-stacked-together-thats-the-depth-of-jupiters-great-red-spot/758706/ “Baby Red Spot” May Have Met Demise on Jupiter https://www.universetoday.com/15600/baby-red-spot-may-have-met-demise-on-jupiter/

The New York Times bestselling author, Anthony Ryan, joins the Am Writing Fantasy podcast for a discussion with Jesper about fantasy writing, publishing, and marketing books in today's publishing landscape.   Find Ryan's books here: https://anthonyryan.net/   Tune in for new episodes EVERY single Monday.  SUPPORT THE AM WRITING FANTASY PODCAST! Please tell a fellow author about the show and visit us at Apple podcast and leave a rating and review.  Join us at www.patreon.com/AmWritingFantasy. For as little as a dollar a month, you'll get awesome rewards and keep the Am Writing Fantasy podcast going.  Read the full transcript below. (Please note that it's automatically generated and while the AI is super cool, it isn't perfect. There may be misspellings or incorrect words on occasion). 0 (2s): You're listening to The Am. Writing Fantasy Podcast in today's publishing landscape, you can reach fans all over the world. Query letters are a thing of the past. You don't even need an literary agent. There is nothing standing in the way of making a living from writing. Join two best selling authors who have self published more than 20 books between them now on to the show with your hosts, Autumn Birt and Jesper Schmidt. Jesper (30s): Hello, I'm Jesper. And this is episode 154 of the Am Writing Fantasy podcast. And Autumn is putting the finishing touches on editing our next novel today. So instead I'm joined by a New York times bestselling author, Anthony Ryan. And normally when I do these interviews, I have like a massive time difference, Anthony, but not today because I think you're in the UK or something. Is that right? Anthony (58s): Yes. Almost instantaneous. Jesper (1m 4s): Yeah. And it's, and there's even light outside my window today, which I'm not used to when I do podcast recordings, but you are you're from Scotland originally. Is that right Anthony (1m 17s): Originally? Yes, I don't sound Scottish, but I was born then spent most of my childhood there. Jesper (1m 24s): I would actually love to visit Scotland one day. I've been to the London and stuff like that multiple times, but I've never been to Scotland and it's just like the scenery there. It's, it's almost a bit fantasy inspiring sometimes. Isn't it? Anthony (1m 39s): It is obviously if you, if you grow up there, you have a different view of things. You don't know you growing up in it, you know, I see landscape the, yeah. Obviously, you know, as a true Scott, I recommend everyone should go to Scotland at least one. Jesper (2m 1s): Yeah. I would really love to go one day, but perhaps before we sort of get started for real here, maybe you could just share a few words about yourself, Anthony, and just talk a bit about what you're writing and maybe how you got into writing. And so on Anthony (2m 17s): Anthony Ryan, the also the raping shadow trilogy, the cottage Memorial, Trelegy blatantly the covenant of steel, excuse my most recent work and I, which is what I'm currently working on. I got published. I self published back in 20 11, 20 12 and was persuaded to go the traditional route when my first novel blood song took off and been a full-time author since the end of 2012. So yeah, this is what I always wanted to do. Anthony (2m 57s): And I consider myself really to be able to make a living doing what I love to do. Jesper (3m 4s): Yeah, that'd be pretty cool. So you have, you have some stuff that you publish and some stuff that is traditional puppets. Is that still the case today? Anthony (3m 14s): Yes. I don't do that much self publishing these days. It's usually one or two things a year, if that, and it's usually a short work, it's a novella or short story or something like that. Full length works with pretty much always traditionally published these days. And to be honest, given the time and I'm sure, you know, better than I do the time it takes to do self publishing. Well, it's a lot of time. It's a lot of efforts to do it properly. And frankly, that was the time to do all sort of being traditionally published for the most part. Anthony (3m 55s): It suits me quite well. Jesper (3m 59s): Right. And you're with penguin IO Anthony (4m 2s): These days is mostly all wet, a little and brown, I believe, but I'm still, you know, technically published by a switch is part of a penguin. So, you know, it's a thing with traditional publishing. You can be a bit confusing with all the different contracts and everything, but I don't think meters care that much, you know, you publish your next book. So yeah. Yeah. Well, within the national publishers as well, got a lot of different contracts and things with various different publishers around the world can be a bit hard to keep track of them all. Jesper (4m 45s): Yeah. But then coming from a situation where you have experience with both the traditional side of publishing, but as well as some self publishing, what would you, sorry? Well, you touched upon this slightly there, but what would you say is the pros and cons of each of those two approaches? If somebody is sort of listening to this and debating, should I do one or the other? Anthony (5m 8s): Well, it's weird. I think the advantages of self publishing are the disadvantages of self publishing of the same things. The advantages are you have to do everything. You know, you do everything yourself. You have complete control over everything. The disadvantages are, you do everything yourself and you have complete control over everything. So, you know, it's, it's a lot of work basically to self publish. We're new at officially published. You will have an editor who works for a publisher. Who's a professional editor. You won't have to hire them yourself, which can be very, probably the most expensive part of the process for self publisher. Anthony (5m 48s): Especially if you're starting out, you know, a professional editor doesn't come cheap. And if you're writing epic fantasy, I mean, and the charge by the word, I mean, typically in the 200,000 word range, paying somebody a word by word basis to edit one of my novels. That's a lot of money would be very expensive for me. So publish as well as very time consuming. But you do, I think with self publishing, you do get control over the control you get. I know we'd be telling you attractive for a lot of people. If you know, I'm a bit of a control freak, I'm not too bad, but I can't be obsessive about details. Anthony (6m 33s): And if you're that kind of person, self publishing is probably going to see it quite well, especially when it comes to cameras and cover design and you know, book descriptions and all that kind of thing. So yes, the advantages are that say are the same as a disadvantage, it's all on you. Or you either do it all yourself or you pay people to do it when you're traditionally published. Some of the burden is taken off you because you're not paying for you are an editor, a cover designer and all of the, Jesper (7m 6s): Yeah. And I'm also thinking maybe what about reread with gods to the editing itself? I mean, of course when you are self publishing, you, as you said, you hire the editor and basically you can just decide what to ignore, what to agree to, whatever, whenever the editor tells you something, but with the traditional publishing, is it more in your experience that you have to more accept what the editor is pushing on you? Or can you still, do you still have the freedom to say like, like, no, that's not going to, I'm not going to change this or that. Anthony (7m 40s): Unfortunately, I've never got to the point where I vehemently disagreed with us in the editors have told me there is a back and forth and other things we don't, you know, sort of mindless things don't always agree with when it comes to word choice, you know, cutting smaller scenes or something like that. But there have been times when I've been asked to do more substantial rewrites and others, some books don't require a lot of work at the editing stage and others do I take the view that these are professional people who've been doing this for entire life and it would be foolish of me to ignore their advice. Anthony (8m 22s): If I ever got to the point where it is vehemently disagreed with what they were asking me to do, I would say, so we did have a discussion, but you know, as of yet, it hasn't come up where it really just completely at loggerheads and can't reach an agreement. I don't know what would happen if we got to that point, you know, contractually, you know, they can reject the book and then they want to have advanced back. We haven't asked, but yeah, that's, that's always the nuclear option, but it it's extremely, rather than the publishing world, you know, for that to happen, you know, it can happen sometimes when you get controversial figures, who've been given large Southerns to write a memoir or something. Anthony (9m 10s): And, you know, especially with the insist on not having a ghost writer. Oh yeah. I've heard stories of people submitting manuscripts that were just unreadable tripe, and then wondering why the, you want to do advance back can happen. But yeah, when it comes to professional writers, people who wrote fiction for a living, it's very, very rare. And as yet, luckily for me as it come on, hopefully no. Jesper (9m 39s): Yeah, no, I agree. And of course it's also a matter of, I mean, of course some editors could be difficult to work with, but so could some authors, right? It could also sometimes be the author who just makes a big deal out of something where the editor might be actually quite fair in what they're asking Anthony (9m 56s): And I'm never going to nitpick over commerce or, you know, stuff like the semi-colons in the wrong place of don't get excited about that. You know, when it comes to, you know, the overall arch arc of the plot and stuff like that, it's, you know, it's pretty rare for them to have a problem with it. In my book, there's been a few things about have, by my own admission, I've gone down the wrong route. I've gotten down a kind of blind alley when it comes to plus and tried to get over and being a bit too convoluted. A good editor will point that out. Anthony (10m 37s): They don't. Yeah. They don't come back and say, oh my God, this is a pile of crap. Where was wrong with you? You get what's called the compliment sandwich. The first paragraph is, oh, this is really great and so on. But the second paragraph is now here's some things I think needs some work. And then the third paragraph is once again, and this is really great novel and I look forward to publishing it. So they always bracket where they actually want to tell you, it's some nice words, sweeten the bell. Yeah. Jesper (11m 9s): But what does your actual writing process look like? Anthony (11m 14s): What I'm writing on right. Every day I rarely have days off. And my thing has to do with when life just gets in the way. So I will, if I have a doctor's appointment or something, or have to do something with family, then, then I'll, you know, I will take time off. But when I'm actually working on book, most of the time I write every day, don't actually produce a huge amount of words on a daily basis. But because I write every day because I'm consistent, you know, it looks from the outside, like I'm quite prolific and I've have reached at least one book a year for the last 10 years, which is a bad, I'm not actually that fast. Anthony (11m 58s): Right. But I haven't consistent. My average word count in these days is about 1200 words a day, but I'm doing the thing where, you know, I use Scribner as my main writing program. And it has, it tells you how many words a day you need to do to reach you or a word goal by a certain date. And these days they just tend to stick to that. And long as you're consistent, as long as you speak to it, it works. Yeah. I don't do a lot of, you know, actually sitting in front of the computer and actual time spent sitting in front of your computer. Anthony (12m 40s): Writing is relatively minimal, but I do do a lot of pacing around my living room. And you know, I remember Stephen fried at the British, you know, comedian and author. He said that writing consists mostly of making coffee for me, even though I drink tea rather than coffee, there's a certain amount of truth in that. There's a lot of things. Jesper (13m 7s): Yeah. I was, I was myself through a, maybe I could call it an experiment, but quite recently, over the last six months, I, because I I'm also at the place short of where you are. I, I, I tend to, I don't really count my word count, but I, I write half a chapter a day because I feel like that's what I can get done in maybe about two hours. And in two hours after that, I feel like my creativity really goes down. But then I heard a lot about many authors who like, are really prolific, you know, the people who write like 5,000 words a day and stuff like that. So I thought like, let me try that. And then I tried to look into all the stuff that they did to increase their word count. Jesper (13m 50s): And I really, you know, pushed myself. And I just came to the realization after a while. I probably tried it for like two, three months. And then by the end of it, I was like, I don't enjoy this anymore. You know, I want to take my time with it. I want to sort of think about what I'm writing. I don't want to just plow ahead. I don't know, for me, it just, it, it moved, removed all the enjoyment of the writing process to try to do it faster. So yeah, Anthony (14m 22s): And also just might be mundane, but I'm not getting any younger. My hands I've typed a lot of words in my life. And after a while it hurts and I don't get on well with dictation software or anything like that. I don't write long hand fast enough to write that. Well, you know, I can write 85 words a minute long hand write eight. So just say my hands are quite happy to not trying to do the 5,000 words a day saying if you can great, if you comfortable for you, good for you. Anthony (15m 5s): You know, but I think probably done photos in words once in a day when I was running up against deadline and it wasn't fun. It definitely would. Jesper (15m 18s): No, I mean, I think when speaking about writing processes, it is really about finding your own sort of what suits you. Of course. I mean, of course, if you have like physical things, like your hands are hurting, then you have to respect that. But, but more in general, I mean that some people enjoy writing fast, other peoples don't. And I think it's actually good in my view to try to experiment with different approaches when you're starting out to figure out what works for you, but then something will probably be something you prefer versus something else. Anthony (15m 48s): Definitely. I think there's no one size fits all when it comes to writing, you have to find it. Yeah. You have to experiment, find what works for you. And I think a lot of people do read whatever their favorite writing book is. Stephen King's on writing or, you know, save the cat or wherever it is and the bank, well, Stephen King writes 2000 words a day. Therefore I must write 2000 words a day. If you've never done that, it's a big ask. You know, it's a big thing to do if you're just not used to it. So, you know, my advice for novice writers is to find your comfort zone and actually embrace the comfort zone. Anthony (16m 32s): Don't try and push yourself too much because what you're doing is difficult. And a lot of the time, especially with people who have jobs, they have families, it's carving out the time. You need to write it, come easy. All you can manage your day is half an hour and you do 500 words by 500 words a day adds up to love words after a year. But yeah, find, find your own comfort zone. Embrace. Not all. We'll give you at least a benchmark to, you know, you know how to push it. You know, you know, if you need to do more, whoever reason then you'll know just how much more you need to do, but tends to be what I tell them. Anthony (17m 15s): Younger writers anyway. Jesper (17m 17s): Yeah, no, I think it's a good advice. And because of as well, the, you know, you've written for quite a while, and as you said, you've written a lot of words, but do you ever feel like when it comes to getting story ideas and so on, do you ever feel like you get stuck in the same loop with the same kind of ideas? Or how do you go about getting fresh ideas? Anthony (17m 39s): You have absolutely no problem with new ideas. To be honest, if we could turn off the idea factory in my head, I would for a while, at least, cause it was a while ago I tweeted, I had 26 books. I could probably start writing tomorrow. If I wanted to. That's probably got up to about 35 now because it just never stops. I just never stopped getting ideas. Ideas are the easy bit for me. Anyway, I'm actually coming up with stories to match the ideas. That's the hard bit, the ideas. Yeah. It's really, I don't go looking for inspiration. Anthony (18m 19s): It always finds me whether it's a television documentary or whether it's, you know, something I saw on the news or just, you know, something I'd read somewhere that I can't even remember where it all goes through my head and just comes together with ideas and they never stop. I'm probably going to shuffle off this mortal coil with a lot of books unwritten, which, and there's not a lot I can do about it. It's just the way it is. Jesper (18m 49s): No, you know, it's funny that you say that because I think when people looking to get into writing or start to write, they worry about this idea thing. But, but because I have it exactly the same way as you do. Well, you know, I have a notebook where I write down when I get ideas and just so chock-full of ideas, it's just like, I don't know. That must be 20 novels in there as well. And I will probably never get to half of them. I don't know. But, but getting ideas is like one of the favorite things that people think about a worry about in the beginning, but, and maybe don't ask some people who are finding it difficult to get ideas. I'm not saying that that doesn't happen, but I have also through this podcast, talk to a lot of different authors by now. Jesper (19m 35s): And I'm yet to hear an established author say that I don't know, I can't get ideas. You know, everybody seems to be flooded with them. Maybe that's part of what makes us writers. I don't know. Anthony (19m 48s): I think it is a thing it's probably something innate to people who do this for a living or at least have the potential to do it for a living is, you know, never running out stories. So this thinking in those terms, I guess you could probably train yourself to do it if you tried hard enough, but it does seem to be something that's just innate with me. You know, even as a kid, I was remember telling the kids go stories at playtime school and Clustered around me and I just make them up on the spot, you know, quite easily. Cause ghost stories are easy, especially when you're telling kid there was a house, it had a ghost in it. Anthony (20m 33s): But yeah, in terms of getting stuck in the same ideas occurring, I'm always keen not to repeat myself. I don't want to be writing the same book over and over again. You know, another summarize have a formula, a character and series of books and those books follow a formula. I don't think there's anything wrong with that. As long as you can keep it fresh, if you're just writing the same book over and over again and you know, rubbing the serial numbers off and making it a little bit different, you know, I think that's going to get very Dallas. It get very Del for me, nevermind the reader. Anthony (21m 14s): And I think fortunately tend to have the imagination. It doesn't get stuck in a rut too much. So it does. I do tend to think outside my own as well as not every idea I get is not for a fantasy novel science fiction. It's hard crime as well. Kind of like to get around to all of those yamas at some point, if we're going to find enough time to write. Jesper (21m 40s): Yeah. Why did you decide that it was fantasy that you wanted to write originally? Anthony (21m 48s): It's just so general. It probably appeals to me more than all others and it might be my, I thought a lot about wine. I think it might be because it's essentially limitless. You can do anything with it, depending on how you construct the world making up a yeah. There's, there's nothing limiting you. You can, you're not constrained by history. You can bowl from history. And I do all the Diana I steal shamelessly from real world history because it's presenting it in the context of fantasy. It doesn't matter so much. There's no copyright on history. You can take all you want. And also you can take away all the inconvenient, messy bits, keep the good bits. Anthony (22m 32s): You know, the realities of history. History is always messier than people think it is. And it never conforms to the myths that people can't do around it in the UK at the moment, there's a lot of people spinning the stallion myths about Britain's past and prior role. You know what we did in the second world war or as my that. And it's clearly being spun by people who don't have a real grasp of what history is or what that particular history was. It's mythmaking, it's not his, but I think from a novelist point of view, especially even if you're presenting it in a fantasy context, you have to engage with the realities of, who's not the mess. Anthony (23m 20s): Otherwise it's not going to be convincing the messiness of history. I think I'd try and reflect even on quite, you know, ruthless and cutting away on the calf and just taking the exciting birds. Still have to go thinking, reflect the messiness on. Jesper (23m 37s): Yeah. And I, I also think, I mean, of course I, you know, I, as part of fantasy, I, I do of course love all your wizards and the magic and, and all that good stuff. But the other part on a more practical level is also as a fantasy author. I feel like it's because I don't want to get bucked down into research about how does this gun work or, or, you know, all those kinds of, or this particular city that the characters now go to that I've never been to. I don't want to do all that research in fantasy. I can just make it up. And that's quite wonderful. Anthony (24m 12s): Yeah. That being said, I do, I do research. I've done because my second series, a, the draconian memoria was set in that sort of industrialized world, even though it was a fantasy world, it was industrialized and they were fighting with guns rather than salts. So the defense of research on guns for that, and here's a tip for you. If you put guns or anything related to guns in YouTube, be prepared for them to bombard you with all sorts of extremist nonsense. We looked at one gun video and within a day, YouTube had decided I was a white supremacist who hated women judging both were recommending me. Anthony (24m 52s): So it's kind of staggering out the algorithms work, Jesper (25m 1s): But yeah, it's a bit scary. Anthony (25m 3s): It is. Yeah. You can see a lesson in how people get rid of medicalized. So stop recommending this to me button quite a lot now. Jesper (25m 15s): Yeah. I can see that. Yeah. It's been a few years though, but, but I, I read the waking fires some years back the waking fire and I very much enjoyed it and it has dragons in it. So that's always good. But what I, why I'm bringing that up is because we were talking a bit about Writing Fantasy and we were talking a bit about what kind of stories to write and so on. And because you have also written and published quite a lot of books, I'm wondering if you, if you see some common tropes within fantasy, that readers seems to like more than others. Jesper (25m 55s): I mean, dragons could be an example, but how do you see the success of your different books? Like, is there like commonalities that the books that has dragons in them or something else are usually more liked by readers than others? Or do you have any views on that? Anthony (26m 10s): I think some people definitely because it requires Memorial, it was guns rather than So that steam ships, you know, air ships and stuff, some people immediately assumed it was steampunk. And it kind of is. And I don't mind if people call it that, but there are people that just won't read anything. It's got steam punk attached to it and a fantasy readers. You only want the songs, even if it has dragons in it, they just want the swords, you know, the medieval setting rather than industrialized setting, which is fine each to their own, you know, but I try not to be constrained by as a writer, readers have their preferences and that's fine. Anthony (26m 51s): But for me as a writer, I do, I do want to be able to write what I want to write, you know? Yeah. And the drugs from the lawyers didn't sell as well as my other series. So it's sold reasonably well for what it is there wasn't in his big numbers because it wasn't, I think fall into what an epic fantasy series was supposed to be. You know, you're supposed to have people riding around on horses, in air ships, you're supposed to, you know, armies fighting great battles with, you know, dragons might be part, but it also supposed to be hordes of saber wielding barbarians and all of this and kind of wasn't in there. Anthony (27m 41s): But I don't think you can, or you should be constrained by redirect expectation. You should write what you want to write because you can never really anticipate what they want. You know? So it's like apple, you know, apple as a company famously doesn't do market research. It makes the things it wants to make itself. People don't know what they want and you can do it. And there's famous examples of then Coca Cola. When they came out with new Coke, they did immense amounts of research and focus groups and market research about, yes, there's definitely a market for new Coke and people want new Coke. Anthony (28m 24s): We put out new Coke, people hated it. Nobody wanted it. It was one of the biggest flops in commercial history. You can't anticipate what they want and you can't try and give them what they want. And you can only write when you write, I think at the end of the day, if it hits it hits is not alive. So you do buy that. I don't think there's anything wrong with writing to market. If you can, don't expect everyone to be a winner just because you write to a certain market. Cause you think, you know, a few years ago it was about empires and umpire romance. Anthony (29m 4s): But just because it's invoked, it doesn't mean it's going to hit for you. You can never really, there's no such thing as a shoe. If I hated in publishing or in anything else. Jesper (29m 14s): No, I fully agree with you there. There's definitely no guarantees one way or the other. And I also agree that it is incredibly important to write something you are passionate about because yeah, like we talked about writing a novel, it takes a lot of time. It takes a lot of effort. So even a month later, you are sort of tired of the thing because it wasn't really your thing. Anyway, then you're never going to get to the end. But of course, if you can find some, some overlap between what the market or the readers want versus what you like, then that's probably a good place to focus. I would say, because at least if you look at like streaming services, Netflix and so on, they pump out the same stuff over and over and over again. Jesper (29m 59s): Right. Because readers or viewers in this case, we want what we, what we know we like, we want the same thing just in a new package. A lot of the time. I mean, when you're trying to do something that is very different. Not always, but most of the time it flops also on Netflix. Anthony (30m 19s): Yeah. I think as a creative though, you can, if you're proud of it, if you think it was good, you're, you know, you're happy with it. That's the most you can expect, you know, if it sells itself, it's great. It's really great for itself. But really from a creative point of view, you, you have to be happy with it. Otherwise what's the point for me anyway, you know, I couldn't there's certainly John was, I couldn't write in, cause I don't read them and I'm not excited about them. No. Yeah. No disrespect to romance authors, but I couldn't write a romance novel to save my life. Anthony (31m 1s): I wouldn't know what the hell I was doing. Me attempting to write a romance novel would be an insult to the young, the, you know, perhaps desperate for money. And I tried it it'd be a disaster. Yeah. So I think you have to be a fan of where the genre you're writing it. And it helps if it's a commercial yarn, you know, if it's very niche, it's going to have a hard time making a living at it. That doesn't mean you shouldn't write in it, but you know, just be aware that it's, it doesn't mean that nobody owes you a living is another thing. Nobody gonna drive a dump truck up to you for DOR and give you a load of money for no apparent reason. Jesper (31m 47s): Ah, that would be nice. But given your years in the writing business, less industry here, are there some changes that you've noticed over the years? Like is there stuff that is very different now compared to what it was when you got started? Anthony (32m 9s): Yeah. The basic publishing process, the process you go through hasn't changed that much. And the contracts are, you know, they're still using pro forma contracts that say you have to provide a written typed manuscript on double spaced paper and all that it's in the contract, but nobody ever does that. You send them an email with an attachment like everybody else. But what I have noticed is, you know, an increasing embracing of digital formats by probably they seem to be taking what I would consider a more realistic approach to pricing of, of eBooks. Anthony (32m 51s): And so obviously it's been a bit of an explosion in audio books, audio books are now much more important. And when I started, you could probably negotiate a different contract, separate contract for your audio book, as opposed to print. And e-book these days, no, none of the major publishers will allow you we'll give you a contract unless you're willing to sell them your, your audio rights. You can't take them away and sell them yourself and they won't do it. You get all the manual fallout so that they're not interested. And I think that's probably true of even the biggest names in the industry. That seems to be a bit of a hard line when the publishing industry, because they've realized that audio books are profitable. Anthony (33m 34s): They're very profitable if they're done well, you know, as a digital item to sell audio books are kind of perfect. You have a reasonably high value and a cost comparison to a print book. Don't cost that much to produce. There's a cost baggage. You have to pay an actor to do them, but you know, it's not as cost-intensive I think, as a print book. So yeah, explosion of audio is probably the biggest thing that I've noticed, but also, you know, publishers using social media for marketing and, you know, various different ways of exploring marketing in a digital age. Anthony (34m 18s): They weren't doing so much of that when I started, but they definitely aren't. Jesper (34m 24s): Yeah. And I think as well there, the audio book explosion is also very much linked to nowadays. Many people are way too busy in their life. So audio book is then like, like podcasting, you know, it's something you can listen to while you're doing other things. And I think in part that's why it has taken off in the sense that it has or to the degree that it has, because it, it just goes better with a busy lifestyle than sitting down to read a book. Nobody has that much time anymore. Unfortunately. Anthony (34m 56s): Yeah. I mean, I'm, I'm, I'm a fan of audio books or certain authors or Stephen King these days. I only do Stephen King audio books. I don't read his books. I only listen to the audio books for him. There's a few others as well. So I find this my preferred format for memoirs, you know, comedic memoirs and that kind of thing, especially when it's written, but it's read by the author. A lot of comedians do audio books a few days, which quietly. Jesper (35m 26s): Yeah, there was something else I wanted to mention here before we, before we wrap things up because I was on your website earlier today. And then I saw a menu item called map room. And that really triggered me because I absolutely love fantasy maps. And it was so wonderful to see an entire webpage on the, on the website dedicated to maps from your books. I really liked that. Anthony (35m 53s): Yeah. I'm a big map fan as well. I draw my old, my own maps for the books and you know, so there's no copyright issues with me putting them on my website. And if you are a fantasy also with maps at the front of your book, I would recommend putting you on the website because they don't show up that well on eBooks kind of fiddly, keep referring back to them when you're reading an ebook, but put them on your webpage. People have a place to go to see them, you know? Yeah. It does seem to be a thing for fantasy funds. They like a good map. Jesper (36m 28s): Yeah. I know. I know for me, myself, if I started reading a new fantasy map, even if it's on the Kindle and I do agree, it's it, the resolution of it is not the best air, but if I do open a new fantasy book and I don't find that map within the couple of first couple of pages, I'm already slightly disappointed. Anthony (36m 48s): Yeah. This is, it's become this thing that we all expect. You know, maybe one day I'll publish a fantasy novel without a mark just to be daring, but probably, yeah, Jesper (37m 1s): That's great. Anthony (37m 3s): I heard about David Gammell, loser delight, great British fantasy also, who never, that only, I think only his historical fantasies have maps in them. They were real well-matched but it's actual secondary world fantasies never had maps. And the story I had once was the, the trying to get hired a guy to do a map for him. And he said, all these characters live on the north pole because they're was going east, west, south, and all that. But it makes no sense when you try and track their movements in impossible direction. So basically impossible his roadmap, David them world. Jesper (37m 44s): Right? No, but it is a challenge because when there is a map, then of course it becomes possible to start tracking the distance and how far were, or, you know, because we have it as well in the, in our novel, when, when I need them to go to one place of the, of the world, to another place of the world, I will actually pull out the map and just sort of figure out, okay, if you were a medieval guy who needed to go this distance, how long would it actually take you? So in one, on one regard, that's good that you can make it more realistic in that sense, but another, but on another hand it also makes it difficult sometimes when you're having multiple points of view and then for one character a month passed. And for the other one, you need to take two days, that's a bit of a jealous, Anthony (38m 27s): It was it's. One of the realities of the medieval world was it took ages to get anywhere. And the average person can walk maybe 10 miles a day. You know, you know, a soldier can do 20 miles a day. Cause that's what they're trained for your average person, you know, carrying goods on that bag. He's not going to manage all in 10 miles a day. So it was a hard reality. Then you try and get rounded, maybe Busey magic or something. But if you want your world at one end of the empire Monday, and then they've made it all the way to the other end by Tuesday, you know, it's just not realistic. Jesper (39m 9s): No, no. That's where, well we love time. And also does some tricks with these. I can't remember what, what Michael or what Jordan called them, but it was this way gates or whatever it was. I can't remember the name for it anymore. Anthony (39m 23s): Yeah. Similar in Robin hops, assassin series over these Stoughton portals, people can go to yeah. It's a useful plot device. If you can get it to a Jesper (39m 36s): Yeah, definitely. All right. Well, I want to thank you, Anthony, as well for coming on the podcast and share from, from all your experience and your insights into writing and publishing. Anthony (39m 48s): I'm sorry. No problem enjoyed it. Jesper (39m 51s): And if people want to learn more about you and your writing, Anthony, where do you want them to go? Anthony (39m 58s): My website has all the links to everything. It's a Anthony Ryan dot net. You'll find links to my social media is on there and details of all my books and learn by them and so forth. Jesper (40m 10s): Excellent. I will put the link to a Anthony's website in the show notes as well. So your deal is now you can go and click directly from there. And once again, I want to thank you, Anthony, for coming on the podcast today and fill in for autumn. So I hope you've got a lot from it and enjoyed it. Narrator (40m 28s): If you like what you just heard, there's a few things you can do to SUPPORT THE AM WRITING FANTASY PODCAST. Please tell a fellow author about the show and visit us at Apple podcast and leave a rating and review. You can also join Autumn and Jesper on patreon.com/AmWritingFantasy. For as little as a dollar a month, you'll get awesome rewards and keep The Am Writing Fantasy Podcast going. Stay safe out there and see you next Monday.

The spaces in between galaxies may be unimaginably vast, but within galactic clusters, they are far from empty. Rather, these expanses are home to a wide range of interplaying, often violent plasma dynamics. In his research, Dr Tom Jones at the University of Minnesota plans to use cutting-edge computer techniques to simulate these processes – shedding new light on physical properties that have eluded astronomers so far. His team's research will not only give crucial insights into some of the largest structures in the known universe, but will also capture the public imagination, and inspire a diverse new generation of astronomers.

In Clustered Injustice and The Level Green (Legal Action Group, 2020), Professor Luke Clements tackles the problem of the way in which "our legal system generates and exacerbates disadvantage." Examining the interconnectedness of disadvantage faced by many minorities - such as people who are homeless, Roma, Gypsies and Travelling people, disabled people, those within the criminal justice system, people who are chronically poor and more - he makes an argument that law segregates individuals' problems into isolated incidences, but rather than solving problems, this segregation exacerbates disadvantage. Injustice is clustered, it is interconnected and law, policy and bureaucracies'  failure to recognise this keeps people in positions of relative disadvantage and limits their opportunities to flourish in their own conception of the good life.  However, it is not all bad news. building on a wealth of professional experience and theoretical insight, Luke offers a roadmap for reform. He seeks to imagine a better system which would be better not just for those who face disadvantage, but for all members of the community.  Luke is the Cerebra Professor of Law and Social Justice at the School of Law, Leeds University. He practised as a solicitor between 1981 and 2021 and in that capacity had conduct of a number of cases before the European Commission and Court of Human Rights. In 1996 he was the solicitor who took the first Roma case to reach the Strasbourg Court Buckley v. UK (1996) Jane Richards is a doctoral student at the University of Hong Kong. You can find her on twitter where she follows all things related to human rights and Hong Kong politics @JaneRichardsHK Learn more about your ad choices. Visit megaphone.fm/adchoices

In Clustered Injustice and The Level Green (Legal Action Group, 2020), Professor Luke Clements tackles the problem of the way in which "our legal system generates and exacerbates disadvantage." Examining the interconnectedness of disadvantage faced by many minorities - such as people who are homeless, Roma, Gypsies and Travelling people, disabled people, those within the criminal justice system, people who are chronically poor and more - he makes an argument that law segregates individuals' problems into isolated incidences, but rather than solving problems, this segregation exacerbates disadvantage. Injustice is clustered, it is interconnected and law, policy and bureaucracies'  failure to recognise this keeps people in positions of relative disadvantage and limits their opportunities to flourish in their own conception of the good life.  However, it is not all bad news. building on a wealth of professional experience and theoretical insight, Luke offers a roadmap for reform. He seeks to imagine a better system which would be better not just for those who face disadvantage, but for all members of the community.  Luke is the Cerebra Professor of Law and Social Justice at the School of Law, Leeds University. He practised as a solicitor between 1981 and 2021 and in that capacity had conduct of a number of cases before the European Commission and Court of Human Rights. In 1996 he was the solicitor who took the first Roma case to reach the Strasbourg Court Buckley v. UK (1996) Jane Richards is a doctoral student at the University of Hong Kong. You can find her on twitter where she follows all things related to human rights and Hong Kong politics @JaneRichardsHK Learn more about your ad choices. Visit megaphone.fm/adchoices

In Clustered Injustice and The Level Green (Legal Action Group, 2020), Professor Luke Clements tackles the problem of the way in which "our legal system generates and exacerbates disadvantage." Examining the interconnectedness of disadvantage faced by many minorities - such as people who are homeless, Roma, Gypsies and Travelling people, disabled people, those within the criminal justice system, people who are chronically poor and more - he makes an argument that law segregates individuals' problems into isolated incidences, but rather than solving problems, this segregation exacerbates disadvantage. Injustice is clustered, it is interconnected and law, policy and bureaucracies'  failure to recognise this keeps people in positions of relative disadvantage and limits their opportunities to flourish in their own conception of the good life.  However, it is not all bad news. building on a wealth of professional experience and theoretical insight, Luke offers a roadmap for reform. He seeks to imagine a better system which would be better not just for those who face disadvantage, but for all members of the community.  Luke is the Cerebra Professor of Law and Social Justice at the School of Law, Leeds University. He practised as a solicitor between 1981 and 2021 and in that capacity had conduct of a number of cases before the European Commission and Court of Human Rights. In 1996 he was the solicitor who took the first Roma case to reach the Strasbourg Court Buckley v. UK (1996) Jane Richards is a doctoral student at the University of Hong Kong. You can find her on twitter where she follows all things related to human rights and Hong Kong politics @JaneRichardsHK Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/public-policy

In Clustered Injustice and The Level Green (Legal Action Group, 2020), Professor Luke Clements tackles the problem of the way in which "our legal system generates and exacerbates disadvantage." Examining the interconnectedness of disadvantage faced by many minorities - such as people who are homeless, Roma, Gypsies and Travelling people, disabled people, those within the criminal justice system, people who are chronically poor and more - he makes an argument that law segregates individuals' problems into isolated incidences, but rather than solving problems, this segregation exacerbates disadvantage. Injustice is clustered, it is interconnected and law, policy and bureaucracies'  failure to recognise this keeps people in positions of relative disadvantage and limits their opportunities to flourish in their own conception of the good life.  However, it is not all bad news. building on a wealth of professional experience and theoretical insight, Luke offers a roadmap for reform. He seeks to imagine a better system which would be better not just for those who face disadvantage, but for all members of the community.  Luke is the Cerebra Professor of Law and Social Justice at the School of Law, Leeds University. He practised as a solicitor between 1981 and 2021 and in that capacity had conduct of a number of cases before the European Commission and Court of Human Rights. In 1996 he was the solicitor who took the first Roma case to reach the Strasbourg Court Buckley v. UK (1996) Jane Richards is a doctoral student at the University of Hong Kong. You can find her on twitter where she follows all things related to human rights and Hong Kong politics @JaneRichardsHK Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/critical-theory

In Clustered Injustice and The Level Green (Legal Action Group, 2020), Professor Luke Clements tackles the problem of the way in which "our legal system generates and exacerbates disadvantage." Examining the interconnectedness of disadvantage faced by many minorities - such as people who are homeless, Roma, Gypsies and Travelling people, disabled people, those within the criminal justice system, people who are chronically poor and more - he makes an argument that law segregates individuals' problems into isolated incidences, but rather than solving problems, this segregation exacerbates disadvantage. Injustice is clustered, it is interconnected and law, policy and bureaucracies'  failure to recognise this keeps people in positions of relative disadvantage and limits their opportunities to flourish in their own conception of the good life.  However, it is not all bad news. building on a wealth of professional experience and theoretical insight, Luke offers a roadmap for reform. He seeks to imagine a better system which would be better not just for those who face disadvantage, but for all members of the community.  Luke is the Cerebra Professor of Law and Social Justice at the School of Law, Leeds University. He practised as a solicitor between 1981 and 2021 and in that capacity had conduct of a number of cases before the European Commission and Court of Human Rights. In 1996 he was the solicitor who took the first Roma case to reach the Strasbourg Court Buckley v. UK (1996) Jane Richards is a doctoral student at the University of Hong Kong. You can find her on twitter where she follows all things related to human rights and Hong Kong politics @JaneRichardsHK Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/sociology

In Clustered Injustice and The Level Green (Legal Action Group, 2020), Professor Luke Clements tackles the problem of the way in which "our legal system generates and exacerbates disadvantage." Examining the interconnectedness of disadvantage faced by many minorities - such as people who are homeless, Roma, Gypsies and Travelling people, disabled people, those within the criminal justice system, people who are chronically poor and more - he makes an argument that law segregates individuals' problems into isolated incidences, but rather than solving problems, this segregation exacerbates disadvantage. Injustice is clustered, it is interconnected and law, policy and bureaucracies'  failure to recognise this keeps people in positions of relative disadvantage and limits their opportunities to flourish in their own conception of the good life.  However, it is not all bad news. building on a wealth of professional experience and theoretical insight, Luke offers a roadmap for reform. He seeks to imagine a better system which would be better not just for those who face disadvantage, but for all members of the community.  Luke is the Cerebra Professor of Law and Social Justice at the School of Law, Leeds University. He practised as a solicitor between 1981 and 2021 and in that capacity had conduct of a number of cases before the European Commission and Court of Human Rights. In 1996 he was the solicitor who took the first Roma case to reach the Strasbourg Court Buckley v. UK (1996) Jane Richards is a doctoral student at the University of Hong Kong. You can find her on twitter where she follows all things related to human rights and Hong Kong politics @JaneRichardsHK Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/law

In Clustered Injustice and The Level Green (Legal Action Group, 2020), Professor Luke Clements tackles the problem of the way in which "our legal system generates and exacerbates disadvantage." Examining the interconnectedness of disadvantage faced by many minorities - such as people who are homeless, Roma, Gypsies and Travelling people, disabled people, those within the criminal justice system, people who are chronically poor and more - he makes an argument that law segregates individuals' problems into isolated incidences, but rather than solving problems, this segregation exacerbates disadvantage. Injustice is clustered, it is interconnected and law, policy and bureaucracies'  failure to recognise this keeps people in positions of relative disadvantage and limits their opportunities to flourish in their own conception of the good life.  However, it is not all bad news. building on a wealth of professional experience and theoretical insight, Luke offers a roadmap for reform. He seeks to imagine a better system which would be better not just for those who face disadvantage, but for all members of the community.  Luke is the Cerebra Professor of Law and Social Justice at the School of Law, Leeds University. He practised as a solicitor between 1981 and 2021 and in that capacity had conduct of a number of cases before the European Commission and Court of Human Rights. In 1996 he was the solicitor who took the first Roma case to reach the Strasbourg Court Buckley v. UK (1996) Jane Richards is a doctoral student at the University of Hong Kong. You can find her on twitter where she follows all things related to human rights and Hong Kong politics @JaneRichardsHK Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

As much as 16 percent of the population suffers from trypophobia, which makes them uneasy at the sight of holes clustered together, as in a honeycomb. Two experts and a sufferer discuss this phobia, which can be remarkably debilitating.

Join Colm in a unique ‘live' episode to celebrate World Alzheimer's Day and  Dementia Action Week.  This episode allows us to join part of the discussion on the 'Stronger Together'   webinar that launched HammondCare and it's Dementia Centre ‘s  partnership with Topaz , a leading Dutch aged care provider.  This conversation centres around the importance of international partnership and knowledge exchange to raise awareness and increase learnings in the field of dementia care and research.  Colm gets out of the host seat and joins the panel, as we join our host Marie Alford, Head of Dementia Services at the Dementia Centre. Marie is joined by Topaz CEO Lia de Jongh, Professor Wilco Achterberg, Leiden University Professor of Institutional Care and Elderly Care Medicine and Professor Susan Kurrle, University of Sydney Curran Chair of Health in Older People.  Don't forget to click on the full webinar link in the show notes to hear,  as the Dutch General Counsel to Australia, Frank van Beuningen and Australian Ambassador to the Netherlands, Matthew Neuhaus help launch this new initiative.   The research paper 'Clustered domestic residential aged care in Australia: fewer hospitalisations and better quality of life' is an example of the work that HammondCare's Dementia Centre will be sharing with Topaz in their knowledge exhange partnership.   Here are some examples of the work that Professor Wilco Achterberg has completed and Topaz will share with HammondCare's Dementia Centre in return.For all feedback please email hello@dementiacente.com.au

En el episodio de hoy, hablo de la mielopatía cervical, y en concreto de la mielopatía cervical degenerativa. Para hablar de este tema, me he basado principalmente en un artículo revisión publicado en Nature en 2020, bajo la autoría de Badhiwala y colaboradores. En esta revisión se realiza una síntesis de información útil para diferentes profesionales que participan en el diagnóstico, evaluación y tratamiento, sobre todo para tener fundamentos para saber cuándo el tratamiento quirúrgico está indicado. Referencias del episodio: (1) Badhiwala (2020). Degenerative cervical myelopathy - update and future directions (https://pubmed.ncbi.nlm.nih.gov/31974455/). (2) Fehlings (2017). Change in Functional Impairment, Disability, and Quality of Life Following Operative Treatment for Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis (https://pubmed.ncbi.nlm.nih.gov/29164033/). (3) Davies (2019). RE-CODE DCM ( RE search Objectives and C ommon D ata E lements for D egenerative C ervical M yelopathy): A Consensus Process to Improve Research Efficiency in DCM, Through Establishment of a Standardized Dataset for Clinical Research and the Definition of the Research Priorities (https://pubmed.ncbi.nlm.nih.gov/31157148/). (4) Cook (2010). Clustered clinical findings for diagnosis of cervical spine myelopathy (https://pubmed.ncbi.nlm.nih.gov/22131790/). Pueden seguirme en: · Twitter→https://twitter.com/JSanchez_PT · Instagram→ https://instagram.com/jsanchez_pt

Sara Zeff Geber wrote the book on Solo Aging—literally! The author of Essential Retirement Planning for Solo Agers: A Retirement and Aging Roadmap for Single and Childless Adults shares what concepts will appeal to this growing market and how senior living operators can satisfy their needs. About Sara Dr. Sara Zeff Geber, 2018 recipient of the “Influencers in Aging” designation by PBS' Next Avenue, is an author, certified retirement coach, and professional speaker on retirement and aging. She has developed a niche specialty working with “Solo Agers,” people who have no children or who are aging alone. Dr. Geber is the author of Essential Retirement Planning for Solo Agers: A Retirement and Aging Roadmap for Single and Childless Adults (Mango Press, 2018) which was selected that year as a “best book on aging well” by the Wall Street Journal. With her speaking and writing, Sara has been raising awareness of Solo Agers for the past 10 years. She believes Solo Agers have unique needs in later life that warrant greater foresight and a more robust approach to planning. Sara is a regular contributor to Forbes.comon the topics of aging and retirement and is a fellow at Nexus Insights, a think tank and incubator for revolutionary concepts in senior living and aging. A sought-after speaker at conferences on retirement and aging, Sara is active in the Retirement Coaches Association, the American Society on Aging, the Life Planning Network, the Transition Network, the Sonoma County Section on Aging, and the Gerontological Society of America. Key Takeaways Twenty percent of baby boomer women did not give birth—half of previous generations. Clustered living environments with a neighborhood feel and communities that develop out of common interests will appeal to solo agers. (see Cozy Home Community) Senior Living operators will need to fill the gap for solo agers with no family support by partnering with service providers.

A rare blend of eloquent lyrical craft and explorative musicianship, the songs of Tiny Ruins have been treasured by crowds and critics for over a decade. Via an eclectic raft of influences, the musical world of Hollie Fullbrook and band spans delicate folk, lustrous dream pop and ebullient psychedelia. Born in Bristol and raised in West Auckland, songwriter & multi-instrumentalist Fullbrook's debut LP Some Were Meant For Sea (2011) features her alone, and was quickly celebrated by radio playlists and blogs worldwide. The album’s clutch of “gorgeous vignettes” (BBC) put the artist on the map, and she took to the road from her home in New Zealand to tour extensively through the UK, Europe and North America – often accompanied by her friend Cass Basil on bass. Following the tape-recorded EP Haunts (2013), produced by Jon Pearce (The Beths), and with the addition of drummer Alex Freer, the then-trio began work on second album Brightly Painted One with producer Tom Healy, who later joined the band on electric guitar. Brightly Painted One (2014) was championed by the New York Times, NPR and David Lynch, & won Best Alternative Album at the New Zealand Music Awards - “…an album of quiet, devastating beauty,” wrote Pop Matters. “...an album that both bruises the heart and lifts the soul...songwriting that demonstrates a novelist’s eye for detail.”— Uncut review of 'Brightly Painted One' In between touring, Fullbrook became a sought after collaborator. A New York recording session culminated in the EP Hurtling Through (2015) with indie-rock legend Hamish Kilgour (The Clean), while single Dream Wave (2016) was recorded and produced by award-winning cult filmmaker and musician David Lynch - “A tranquil, pared-back track [with] a gradually rising sense of the macabre… very special indeed.”— The Line of Best Fit Building on the sparse minimalism and intricate songwriting of earlier releases, the band’s third album Olympic Girls comprises a taut and agile quiver of songs, dancing with explorative instrumentation and a pop sensibility that springs with life. “How much would you be willing to give?” Fullbrook asks point-blank in first single ‘How Much’, ahead of woozily discordant strings and a stomping neo-psychedelic rhythm. The lyric brims with imagery of supermarket breakdowns, lilos, snarks and silos while an anthemic guitar hook soars throughout. Not content to leave the song at a stable conclusion, a thumping ‘I am the Walrus’-esque bass outro propels the track boomerang-style back to a space of adroit experimentation. “I've heard Olympic Girls, and I had to pick my jaw up off the floor”, wrote https://www.stuff.co.nz/auckland/108148664/Tiny-Ruins-Hollie-Fullbrooks-new-album-jaw-dropping (Grant Smithies). “Clustered around more introspective passages typical of confessional singer-songwriters are gnarlier phrases that give her work its buzzy voltage: arresting visual images, weird associations, daisy-chains of telling detail.” See https://www.tinyruins.com/shows (Tour Dates.) MOJO Review of Olympic Girls - ★★★★ UNCUT Review of Olympic Girls - 8/10 "Part of the charm of Olympic Girls lies in the layers of mystery in each song. Inspired by literature, science, nature and human experience, these mysteries lie waiting to be carefully unfolded…” God Is In the TV - 9/10 "An album confident in its vulnerability and luxuriating in a bigger sound." Loud & Quiet Review of Olympic Girls - 8/10 "… songs that change sound and mood during their duration, never meandering and always captivating.” BUST Review of Olympic Girls - 5/5 “… a deeper listen to these eleven tracks exposes a breadth of influences that spans decades.” - The Wire Review of Olympic Girls “She is always looking uneasily toward the next line, or moving toward mysticism. In sentimental contexts, she generates lines of wicked ambition.”— The New York Times “Fullbrook’s hushed yet forceful songs, packed with obsessives and...

Interneurons from Embryonic Development to Cell -Based Therapy, Embryonic Origin of Postnatal Neural Stem Cells, Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults, Maintenance of neural stem cell positional identity by mixed-lineage leukemia, and Clustered gamma-protocadherins regulate cortical interneuron programmed cell death Prof. Arturo Alvarez-Buylla is Professor, Neurological Surgery at UCSF. His laboratory studies the mechanisms of adult neurogenesis and neuronal replacement. --- Send in a voice message: https://anchor.fm/scientificsense/message Support this podcast: https://anchor.fm/scientificsense/support

¡Hola, jugadores! Volvemos con un segundo volumen de uno de los programas que mejor sabor de boca nos ha dejado. Vuelve a visitarnos Jorge Nieva para escarbar en sus estanterías y traernos algunos juegos que no han tenido el foco mediático sobre ellos pero que merecen ser rescatados. Tendremos nuestras secciones habituales: - Cápsula de escape: 00:05:21      Nuestro particular cajón de sastre donde comentamos lo que ha despertado nuestro interés últimamente. - Campo de asteroides: 00:35:29      Hacemos la segunda parte de "Juegos que no conoces" un programa que nos dejó un estupendo sabor de boca. Los juegos comentados por Jorge en el programa son estos: Funny Friends, OffBoard, Lex in Lemniscate, Clustered, Too many cinderellas, El osito curioso, Candy Chaser, Diamonster, Say bye to the villlains, The new science., Consumption, food and choices y Bear valley.  - Torre de control: 01:30:03     Os contamos a qué hemos jugado últimamente: -Warp's edge. 01:31:51 -Under falling skies.  01:39:34 -Forgotten Waters. 01:45:20 -Hallertau. 02:04:00 -Fossilis.  02:14:13 -Lost ruins of Arnak.  02:21:04 -Sala de comunicaciones: 02:28:14 Con vuestros comentarios del último programa. ¡Que lo disfrutéis!

¡Hola, jugadores! Volvemos con un segundo volumen de uno de los programas que mejor sabor de boca nos ha dejado. Vuelve a visitarnos Jorge Nieva para escarbar en sus estanterías y traernos algunos juegos que no han tenido el foco mediático sobre ellos pero que merecen ser rescatados. Tendremos nuestras secciones habituales: - Cápsula de escape: 00:05:21      Nuestro particular cajón de sastre donde comentamos lo que ha despertado nuestro interés últimamente. - Campo de asteroides: 00:35:29      Hacemos la segunda parte de "Juegos que no conoces" un programa que nos dejó un estupendo sabor de boca. Los juegos comentados por Jorge en el programa son estos: Funny Friends, OffBoard, Lex in Lenmiscate, Clustered, Too many cinderellas, El osito curioso, Candy Chaser, Diamonster, Say bye to the villlains, The new science., Consumption, food and choices y Bear valley.  - Torre de control: 01:30:03     Os contamos a qué hemos jugado últimamente: -Warp's edge. 01:31:51 -Under falling skies.  01:39:34 -Forgotten Waters. 01:45:20 -Hallertau. 02:04:00 -Fossilis.  02:14:13 -Lost ruins of Arnak.  02:21:04 -Sala de comunicaciones: 02:28:14 Con vuestros comentarios del último programa. ¡Que lo disfrutéis!

Are there too many underutilised qualifications in the Australian VET system? Are some qualifications past their expiration date?  One method of reducing qualifications involves grouping them into vocational clusters so individuals can train for several jobs at once. This approach also creates greater transferability of skills in the labour market.  Do we have the appetite for such transformative change? Is there a role for good quality training that may sit outside the formal national training system?Steve Davis talks to Professor John Buchanan, Business School, University of Sydney, David Morgan, CEO, Artibus Innovation and Simon Walker, Managing Director, NCVER about the notion of ‘clustering’ qualifications into vocational streams for a range of occupations and how it could be achieved. 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.08.363200v1?rss=1 Authors: Kim, N., Bahn, S., Choi, J. H., Kim, J. S., Rah, J.-C. Abstract: The posterior medial nucleus of the thalamus (POm) and vibrissal primary motor cortex (vM1) convey a set of critical information regarding whisker position and movement to the barrel cortex (S1BF), and integration of these inputs is essential for whisker-based object localization. A considerable portion of these inputs locates on the distal tuft dendrites of layer (L) 5 pyramidal neurons, where regenerative dendritic activity determines the successful activity propagation. Therefore, understanding the relative spatial relationship and distribution of the inputs are critical prerequisites to acquire insight into how S1 synthesizes information to understand the location of an object. Using array tomography (AT), a high-resolution wide-field microscopy imaging technique that can accurately resolve synapses, we detected the locations of synapses from vM1 and POm on 18 distal tuft dendrites of L5 pyramidal neurons. We found that synapses from M1 and POm impinge on the dendrites with unusually high density and spatial clustering judged by various independent clustering analysis. We believe the exhaustively high density of synaptic inputs, as well as spatial clustering, could enhance the chance of successful dendritic spikes to mitigate the electrotonic disadvantages of the distal inputs. Furthermore, we found that the synaptic clusters of vM1 and POm locate close to each other on the same set of branches, suggesting that synaptic clusters but not dendritic branches, act as functional units cooperatively contribute to the nonlinear dendritic responses. Copy rights belong to original authors. Visit the link for more info

This week on the podcast, Dan and Kyle talk about running PeopleSoft applications in a cluster and with federated approval and push notifications. We discuss some of the configurations needed for federations and our lessons learned. Show Notes Presence of IT Cloud White Paper @ 1:00 Fluid Home Button URL @ 5:30 Federated Push Notifications Bug @ 11:00 Clustered Application Concerns and Testing @ 17:00 Federated Approvals @ 21:45