Podcasts about cko

It's the holiday season so hoop-de-do and dickory dock and don't forget we're off for the next two weeks!We rewind to the art opening at the Herb and Milly Iris Gallery, the Baker Square dedication, and even more holiday preparations.We are looking forward to ribbon cuttings, a wine tasting, a tiki pop-up bar, Dickens Village, a holiday market, the Local D, Old Year's Eve, and embroidery journals.Three Things with free karate classes, the SO Elf Chase, join a Maplewood Township committee, a vintage Pop-Up, Fox and Falcon, and CKO.Our last Co-Lab Thing To Know all about the Co-Lab marketplace, a gingerbread house decorating event, and two pop-ups this weekend!Whatever you celebrate, have a great holiday everyone!LINKS:South Orange "Elf Chase Giveaway"Maplewood Township boards and committees Crash Doll Vintage Pop-Up CKO rebranding

Join us this week as we sit down with Conroy Copeland and Frank Clayton. Sensei Copeland began his karate training around the age of 15. He has been taught and trained under renowned martial arts instructors like Sensei Richard Kim, Morio Higaonna, and Professor Wally Jay, gaining valuable knowledge that he now shares with his students, some of whom run their own dojos. In 1975, Conroy met Sensei Don Warrener at a tournament and became his student, training at DWMA until the early 1990s when he began learning from Sensei Teruo Chinen, who has been his teacher for the last 20 years. As a competitor, he has represented national teams worldwide for WKO, Karate Ontario, and CKO, earning numerous championships. Sensei Copeland has been teaching since 1978 and has successfully run Copeland's Martial Arts since then. Additionally, he has hosted the Windsor Open Karate Championships for over 20 years, making it one of the region's longest-running tournaments. In 2023, Sensei Conroy Copeland was inducted into the Canadian Black Belt Hall of Fame. Sensei Clayton, born in Halifax in 1959 and raised in Montreal, began his martial arts journey with Judo and Boxing before fully immersing himself in Karate in 1971 after moving to Hamilton. He joined Don Warrener's Delta club in 1977, earning his black belt in 1980. Over the years, he has helped his students open their own dojos, mentoring them to positively impact their communities. With over 10,000 students taught and more than 300 black belts produced, Sensei Clayton has built a lasting legacy in martial arts. Renshi Clayton is a 7th dan in Okinawan Goju Ryu Karate and a 5th dan in Ryu Kyu Kobudo. Sensei Clayton continues to teach and pursue his own training, regularly traveling to Okinawa. In 2024, Sensei Frank Clayton was inducted into the Canadian Black Belt Hall of Fame. #PKCC #martialarts #karate

In dieser Sonderfolge von "Gute Besserung" erzählt Prof. Dr. Dieter Lüttje, Leiter medizinische Infrastruktur am Klinikum Osnabrück, wie sich das Klinikum auf die Bombenentschärfung in Osnabrück am 17.11. vorbereitet. Im Zuge der geplanten Bombenräumung am 17.11.2024 in Osnabrück laufen die Vorbereitungen in den Krankenhäusern in Stadt und Landkreis Osnabrück auf Hochtouren. Das Marienhospital Osnabrück (MHO) und das Christliche Kinderhospital Osnabrück (CKO) liegen im Evakuierungsgebiet. Das MHO wird am 17.11.2024 ab 7 Uhr nicht durch den Rettungsdienst angefahren und ist auch fußläufig nicht zu erreichen. Für verbleibende Patienten und Mitarbeitende greift ein umfangreiches Sicherheitskonzept. 

In this episode of Fringe Legal, recorded live from ILTACON 2024 in Nashville, Tennessee, Ab sits down with JoeySeeber, CEO of Level Legal. Joey discusses the journey and growth of Level Legal over 15 years, starting during the Great Recession. The conversation delves into various aspects of building a business for longevity, maintaining a startup mindset in a small company, and delivering services in a human-centric way. Joey shares insights on their framework and principles for doing business, client feedback, handling competition, and the role of technology in enhancing efficiency. Read the episode takeaways at: https://www.fringelegal.com/balancing-technology-and-human-connection-in-legal-services-with-joey-seeber

O Podcast Canaltech está no ar! No programa de hoje: Samsung lança Galaxy Ring, novos dobráveis (Galaxy Z Flip 6 e Galaxy Z Fold), Galaxy Watch Ultra, Galaxy Ring e novos Galaxy Buds 3 e 3 Pro; Google vai liberar relatório de dark web para todas as contas; transplante de laringe faz paciente com câncer voltar a falar; Microsoft e Apple desistem de fazer parte do conselho da OpenAI; missão da NASA que vai desvendar sinais de rádio vindos do Sol é lançada. E mais: reprise da entrevista de Gustavo Minari com Marcelo Barros, CKO da CNA, falando sobre o uso da inteligência artificial no aprendizado de idiomas. Receba notícias do Canaltech no WhatsApp Conheça o Porta 101 Entre nas redes sociais do Canaltech buscando por @Canaltech nelas todas. Entre em contato pelo nosso e-mail: podcast@canaltech.com.br Entre no Canaltech Ofertas Este episódio foi roteirizado e apresentado por Luciana Zaramela. O programa também contou com reportagens de Leo Muller, Guilherme Haas, Nathan Vieira, Bruno de Blasi e Danielle Cassita. Edição por Yuri Souza. A trilha sonora é uma criação de Guilherme Zomer e a capa deste programa foi feita por Erick Teixeira. See omnystudio.com/listener for privacy information.

Com o crescimento exponencial da Inteligência Artificial, novas abordagens para aprender e compreender idiomas estão surgindo. No entanto, a IA deve ser vista como uma ferramenta de apoio, não como uma substituição no aprendizado de idiomas ou uma ferramenta mágica que fará o trabalho por você. Para falar sobre esse assunto eu recebo hoje aqui no Podcast Canaltech o Marcelo Barros, CKO da CNA. Este é o Podcast Canaltech, publicado de terça a sábado, às 7h da manhã no nosso site e nos agregadores de podcast. Conheça o Porta 101. Entre nas redes sociais do Canaltech buscando por @Canaltech nelas todas. Entre em contato pelo nosso e-mail: podcast@canaltech.com.br Entre no Canaltech Ofertas. Este episódio foi roteirizado e apresentado por Gustavo Minari. O programa também contou com reportagens de Bruno De Blasi, Guilherme Haas, Felipe Demartini e Vinícius Moschen. Edição por Vicenzo Varin. A revisão de áudio é do Wallace Moté. A trilha sonora é uma criação de Guilherme Zomer e a capa deste programa é feita por Erick Teixeira.See omnystudio.com/listener for privacy information.

In this episode of the Fringe Legal podcast, host Ab interviews Stefan Ciesla, the co-founder and CEO of Ayora ai, a startup that focuses on helping law firms manage their revenues and improve the revenue management skills of fee earners such as attorneys and lawyers. Steven discusses the problem Ayora is solving in the legal industry and the role of lawyers as revenue managers. He explains that fee earners often have to make revenue management decisions throughout a matter's lifecycle, but they may not have the necessary skills or focus on revenue management. Ayora's smart lockup assistant helps fee earners by scanning a firm's data related to matters and providing recommendations on monitoring scope, estimates, budgets, resourcing, outside counsel guidelines, and billing. The assistant pre-drafts emails and provides relevant information to make the decision-making process easier and more efficient. Steven also addresses the challenge of balancing AI and machine learning with human control and building trust in the recommendations made. He emphasizes that Ayora prioritizes transparency and user consent and never takes any action without the attorney's knowledge. Key takeaways: Fee earners in law firms, such as attorneys and lawyers, often need to make revenue management decisions throughout a matter's lifecycle but may not have the necessary skills or focus on revenue management.Ayora's smart lockup assistant helps fee earners monitor scope, estimates, budgets, resourcing, outside counsel guidelines, and billing, providing recommendations and pre-drafting emails to make decision-making easier and more efficient.Ayora prioritizes transparency and user consent, ensuring that attorneys have control over the recommendations made by the system.Uncommon learning The legal industry may be missing out on billions of dollars of additional value due to suboptimal revenue management decisions.Podcast show notes00:02 Introduction to the Fringe Legal Podcast00:29 Guest Introduction: Stefan Ciesla, Co-founder and CEO of Ayora00:58 Steven's Background and Ayora's Founding Team02:07 The Unique Blend of Ayora's Founding Team02:55 Understanding Ayora's Mission and Purpose04:24 The Role of Lawyers as Revenue Managers04:43 The Impact of Decision-Making on Revenue Management08:28 Introducing Ayora's Smart Lockup Assistant20:20 The Role of AI and Machine Learning in Decision-Making27:05 The Impact of Fixed Fee Work on Revenue Management30:12 Conclusion and Contact Information

In this episode of the Fringe Legal podcast, host Ab chats with Conan Hines, Director of Legal Technology at Fried Frank, about building a tech-enabled culture in law firms. Conan shares insights from his previous roles at Clifford Chance and other law firms, highlighting the importance of understanding the role of legal technology and the psychology and behavior of users when it comes to successful adoption and change management.Conan emphasizes the need for building trust with lawyers and finding those who are curious and open to tech-enabled solutions. He suggests starting small with bite-sized engagements to build trust over time. He also discusses the value of creating a foundation for tech adoption and balancing short-term impact with long-term goals.The conversation delves into the role of vendors in adoption, with Conan highlighting the need for a strong partnership and a transparent framework for success. He stresses the importance of vendors having a real adoption strategy and sharing learnings from what has worked in the past.Ab and Conan also discuss the challenge of incentives and tracking adoption. They explore the idea of integrating technology training into legal training to emphasize the value and importance of tech skills for lawyers. Ultimately, the key to successful adoption and building a tech-enabled culture in law firms lies in trust, continuous communication, and demonstrating the value of technology.Key takeaways:Building a tech-enabled culture requires understanding the role of legal technology and the psychology and behavior of users.Trust is essential for successful adoption. Lawyers need to believe that tech solutions can help them.Adoption plans should be simplified and tailored to individual users.Integration of technology training into legal training can help emphasize the value of tech skills for lawyers.Vendors should have a strong adoption strategy and share learnings from past successes.Uncommon learning:Tech adoption requires a partnership between law firms and vendors, with a focus on transparency and continuous communication.

While technology races ahead, improving legal training and education has lagged behind. Law schools excel at teaching students the law, but critical and practical skills development is often lacking. With the traditional law firm apprenticeship model fading, junior lawyers frequently lack opportunities to gain hands-on experience.Abdi Shayesteh, founder and CEO of the legal training platform AltaClaro, is on a mission to close this practical skills gap. Frustrated by the inefficiencies he experienced firsthand as a junior lawyer, Abdi has reinvented legal education and training. AltaClaro leverages experiential learning techniques rooted in education science to provide associates with hands-on practice on simulated legal matters.Show Notes [00:01:14] Abdi's early entrepreneurial experiences managing a cafe and starting a t-shirt business in college [00:08:02] Why Abdi decided to start another company after previous exits [00:10:25] Overview of what AltaClaro does [00:17:38] Issues with the traditional law firm training model [00:23:00] Explanation of the learning science principles AltaClaro leverages [00:34:59] Training trends Abdi sees law firms requesting for 2023

As part of our series of examining Generative AI in Practice, Fringe Legal spoke with Stephanie Corey, founder of legal operations consultancy UpLevel Ops, and Brandi Pack, UpLevel's Legal Tech Analyst & AI Consultant. They share how legal teams can thoughtfully leverage generative AI to transform workflows, augment human skills, and futureproof roles. With proper governance and training, we can keep pace with the evolution of AI and maximize its potential.Show notes:Show Notes:[00:02:19] Getting early access to GPT-4[00:08:00] How are the Uplevel Ops team grew adoption internally[00:11:53] People don't care about AI[00:14:51] Why to document prompts[00:18:06] How are legal teams reacting to the changing landscape[00:28:38] GenAI as a workflow tool[00:31:03] What's the future?[00:34:16] Will my role be displaced?[00:38:47] What one thing can organizations do to see immediate value from GenAI?

We sat down with Jeff Pfeifer, Chief Product Officer at LexisNexis during ILTACON 2023 to get his insights on legal AI progress, hype versus reality, increased law firm adoption, and the importance of demonstrating tangible benefits.Topics covered: Navigating the legal AI hype cycle AI's potential to enhance legal workflows Growing law firm interest and hands-on exploration Avoiding the “trough of disillusionment” Real-world benefits driving adoption over hype

In this episode of Fringe Legal, host Abhijat Saraswat interviews Nnamdi Emelifeonwu and Feargus MacDaeid, co-founders of legal tech startup Definely.Key Takeaways: Definely creates software plugins to simplify drafting, reviewing, and analyzing legal contracts in Microsoft Word using AI/ML. The idea originated from Feargus' need as a blind lawyer to access information in documents more easily. They validated demand with a scrappy prototype and early pilots despite its flaws. After leaving law firm jobs, their mission-driven approach focuses on access, efficiency, and transparency. Their blueprint for innovation includes launching an MVP, inclusive design thinking, gathering user feedback, and carefully leveraging AI. Maintaining ethics and reputation is central, not rushing new technology to market. When solving problems for underserved groups, solutions often benefit everyone. A framework for evaluating AI: accuracy and understanding real-world impacts. Connect with Nnamdi EmelifeonwuConnect with Feargus MacDaeidLearn more about Definely

ESG (environmental, social, governance) factors have become essential considerations for companies seeking to manage risk, attract investment, and operate sustainably.Yet myths and misconceptions persist around what ESG is and how best to approach it. This leads many legal teams to view ESG as an amorphous compliance exercise rather than a strategic priority.Recently on the Fringe Legal podcast, Abhijat Saraswat interviewed ESG expert Kai Gray, CEO of advisory firm Motiv, to demystify ESG and offer practical guidance for legal professionals. In this episode, learn what ESG means and how legal teams can pragmatically prioritize it. Get clarity on ESG frameworks, strategic rollout, and avoiding common pitfalls.

Summary:In this insightful episode of Fringe Legal, host Abhijat Saraswat has an in-depth discussion with India Preston, Director of Platform Solutions at legal tech startup Lupl. They delve into India's winding journey into legal project management, tactical approaches to driving adoption, and how to effectively challenge established processes.India shares learnings and advice drawn from her diverse experiences - from helping build out Linklaters' LPM function from the ground up to make the leap to an early-stage legal tech startup. She provides a rare longitudinal view of how legal project management has evolved from a little-known concept in 2013 to a widely recognized, if still poorly understood, discipline today.Key Takeaways: While LPM has gone from barely existing in 2013 to being commonly known today, there is still substantial room for education on how to apply it effectively. LPM principles empower lawyers to run matters like projects, but specialized LPM roles create incremental value on complex matters. Project management qualifications alone don't cut it for legal project managers to be successful. Soft skills to integrate smoothly with lawyers and legal teams are just as important, if not more so. Technical skills can be learned on the job. Identifying concrete problems that need solving is absolutely crucial before adopting any new solution or technology. Without an anchor in specific pain points, adoption will struggle no matter how exciting the new solution seems at first glance. Rollouts of new technology or processes should start small and be targeted before expanding more widely across a firm. The tendency may be to go big with a splashy firmwide launch, but this rarely succeeds. Resources like use case guides, template libraries, and informal user communities help drive adoption by making the novel feel familiar. However, these need to be grounded in solving real firm problems. Process mapping workshops - with the help of an unbiased external facilitator - can challenge status quo thinking and processes in extremely constructive ways. Just asking "why" repeatedly can unearth entrenched inefficiencies. Actionable Takeaway: Start Small Before Going WideExplore in detail at Fringe Legal.

Premier épisode de la troisième saison de Startup Mafia ! Cette saison est consacrée à Checkout et sera divisée en deux parties. La première mettra en avant certains des employés qui ont rejoint CKO depuis le début, ainsi que des talents issus de ProcessOut, la première acquisition de CKO réalisée en février 2020. La seconde sera l'occasion de découvrir les C-Level UK & U.S, leurs rôles et les challenges qu'ils ont depuis la dernière levée de fonds d'un milliard de janvier 2022. On commence cette saison avec Antoine Nougué, Global Head of Commercial chez Checkout, un rôle clé qu'il incarne parfaitement, ayant lui-même contribué individuellement et collectivement à toutes les étapes commerciales et la croissance vertigineuse du service de paiement depuis le début.Antoine est un pur produit Checkout. Son ambition s'est nourrie de celle de Guillaume, le fondateur de CKO, depuis qu'il a recruté sorti d'école.  On parlera bien sûr de son parcours, de sa relation très étroite avec le CEO, mais aussi des challenges à venir et de son rôle dans l'écosystème. 

In this episode, our guests Brad Blickstein, David Cambria, and returning guest Keith Maziarek join host Ab to discuss the findings from the 3rd Legal Pricing and Project Management (LPMM) Survey Report. They delve into the key challenges and trends shaping the legal industry, touching upon innovation, technology, client expectations, and the future of legal service delivery. Tune in to explore the data and analysis from the report, as these experts share their perspectives on the current state and future of legal operations.Key discussion points: [00:02:16] The current state of law firm investments in innovation and technology [00:10:45] Contradictions between client expectations and rewarded behaviors [00:18:50] Challenges faced by law firm and legal department executives in adopting process and collaboration improvements [00:27:12] The real threat to law firm success and how to address it [00:34:23] The impact of economic downturns on the legal industry and the potential for future transformation Don't miss this in-depth conversation that offers valuable insights for legal professionals interested in legal tech, legal project management, and legal service delivery.A more in-depth commentary is available on FringeLegal.com

Which hood do you represent and does your hood have an anthem? This is a playlist of Kenyan hood anthems. Ado Veli Podcast Season 11 Episode 19, which is episode number 279. Get Ado Veli Podcast Merchandise here: https://adovelipodcast.hustlesasa.shop/ Tracklist Juicee Mann ft CKO and Nare - Kilipesa 0:00:00 Adebo ft All Stars - TNM Remix 0:02:38 Davaji - 1000 Streets 0:09:00 Buruklyn Boyz - Location 58 0:12:18 OHMS Law Montana - Kisauni 0:15:10 Big Yasa ft Mbarish - Kibera 0:25:35 Wakadinali - Umoroto 0:28:57 Clinchy Royal ft Oluvee, Skrilla, Mwaki and Capital G - Jeshi Ya Dago 0:33:21 Muki Rai - GekoyoGekoyo 0:38:02 Tunji - Mat Za Ronga 0:40:25 D'jungle ft Ayrosh - Thika Ruiru 0:51:55 Ukoo Flani - Dandora L.O.V.E 0:55:04 Walangunzi - Eastlands Anthem 0:57:49 Reagan Dandy ft Tricks and Lavidoh - Kilifi 1:01:17 Zzero Sufuri ft Kadu - Wase Wase 1:04:06 Super Kairo - 001 (Mombasa) 1:08:00 Listen to Ado Veli Podcast on; Apple Podcast, Spotify, Boomplay, Google Podcasts, Anchor, Mixcloud, TuneIn and Stitcher https://smarturl.it/adovelipodcast Tune in, listen and share your thoughts on social media with our official hashtag #AdoVeliPodcast. Follow us on; Facebook Page: https://www.facebook.com/penninah.wanjiru.902 https://www.facebook.com/ADOVELl/ Twitter: https://twitter.com/penninahwanjir1 https://twitter.com/AdoVeliRadio Instagram: https://www.instagram.com/penninah_wanjiru/ https://www.instagram.com/adoveli/ Email: adoveli7@gmail.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.15.536995v1?rss=1 Authors: Tarusawa, E., Hasegawa, S., Noda, D., Kawamura, N., Fukazawa, Y., Watanabe, M., Hirabayashi, T., Yagi, T. Abstract: Clustered protocadherins (cPcdhs) are candidates for the neural circuit formation; however, the localization of cPcdhs in pre- and post-synaptic compartments has not been well characterized. Here we examined the localization of cPcdh{gamma} proteins in the mouse hippocampal CA1 region using light and electron microscopy. From postnatal day 7 to 21, cPcdh{gamma} immunosignals were detected in approximately 40-60% of spines of pyramidal cells. SDS-digested freeze-fracture replica labelling revealed that cPcdh{gamma} immunolabeling was found in 50% of PSD 95-positive postsynaptic profiles but only in less than 10% of vGluT1-positive pre-synaptic terminals. Interestingly, cPcdh{gamma}-positive pre-synaptic terminal was exclusively accompanied by cPcdh{gamma}-positive postsynaptic counterpart. In addition, electrophysiological investigations revealed that the miniature excitatory postsynaptic current frequency in cPcdh{gamma} cKO mice was significantly higher than that in wild-type mice. These results suggest that cPcdh{gamma} proteins are unequally distributed in the pre- and post-synaptic membrane during neural circuit development and regulate the number of excitatory synapses. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Russell All Time was two hours late and so we filled the time talking about CSW, RPW, IPW, CKO, and all the other local acronyms. When he finally arrived, we gave him hell for his questionable opinions about who the GOAT is (it's Michael Jordan, NOT Lebron James).Also, a rant about how not to be a jerk.

Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) published a new research paper in Volume 15, Issue 4, entitled, “Isoform-specific effects of neuronal repression of the AMPK catalytic subunit on cognitive function in aged mice.” AMP-activated protein kinase (AMPK) functions as a molecular sensor that plays a critical role in maintaining cellular energy homeostasis. Dysregulation of the AMPK signaling has been linked to synaptic failure and cognitive impairments. In a recent study, researchers Xueyan Zhou, Wenzhong Yang, Xin Wang, and Tao Ma from Wake Forest University School of Medicine demonstrated abnormally increased AMPK activity in the hippocampus of aged mice. The kinase catalytic subunit of AMPK exists in two isoforms α1 and α2, and their specific roles in aging-related cognitive deficits are unknown. “Taking advantage of the unique transgenic mice (AMPKα1/α2 cKO) recently developed by our group, we investigated how isoform-specific suppression of the neuronal AMPKα may contribute to the regulation of cognitive and synaptic function associated with aging.” The team found that aging-related impairment of long-term object recognition memory was improved with suppression of AMPKα1 but not AMPKα2 isoform. Moreover, aging-related spatial memory deficits were unaltered with suppression of either AMPKα isoform. Biochemical experiments showed that the phosphorylation levels of the eukaryotic initiation factor 2 α subunit (eIF2α) were specifically decreased in the hippocampus of the AMPKα1 cKO mice. They further performed large-scale unbiased proteomics analysis and revealed identities of proteins whose expression is differentially regulated with AMPKα isoform suppression. These novel findings may provide insights into the roles of AMPK signaling pathway in cognitive aging. “In summary, the current study reported that suppression of neuronal AMPKα1 isoform can improve aging-related impairments of long-term recognition memory.” Full Paper: DOI: https://doi.org/10.18632/aging.204554 Corresponding Author: Tao Ma - tma@wakehealth.edu Keywords: AMPK, aging, protein synthesis, learning and memory, proteomics Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204554 About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.05.531223v1?rss=1 Authors: Morishima, T., Fakruddin, M., Masuda, T., Wang, Y., Schoonenberg, V. A. C., Butter, F., Arima, Y., Akaike, T., Tomizawa, K., Wei, F., Suda, T., Takizawa, H. Abstract: A lack of the mitochondrial tRNA taurine modifications mediated by mitochondrial tRNA translation optimization 1 (Mto1) was recently shown to induce proteostress in embryonic stem cells. Since erythroid precursors actively synthesize the hemoglobin protein, we hypothesized that Mto1 dysfunctions may result in defective erythropoiesis. Hematopoietic-specific Mto1 conditional knockout (cKO) mice were embryonic lethal due to niche-independent defective terminal erythroid differentiation. Mechanistically, mitochondrial oxidative phosphorylation complex-I was severely defective in the Mto1 cKO fetal liver and this was followed by cytoplasmic iron accumulation. Overloaded cytoplasmic iron promoted heme biosynthesis and enhanced the expression of embryonic hemoglobin proteins, which induced an unfolded protein response via the IRE1 -Xbp1 signaling pathway in Mto1 cKO erythroblasts. An iron chelator rescued erythroid terminal differentiation in the Mto1 cKO fetal liver in vitro. The new point of view provided by this novel non-energy-related molecular mechanism may lead to a breakthrough in mitochondrial research. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.13.527949v1?rss=1 Authors: Ruan, J., Xie, H., Quan, X., Zhang, Y., Zhang, D., Wang, W., Hu, X., Tao, Y., Zhao, B., Lu, D., Jia, J.-M. Abstract: Proper brain function depends on intact neurovascular coupling (NVC). Through NVC, local cerebral blood flow (CBF) is rapidly increased in activated cerebral regions to meet the corresponding demands of neural activities. NVC has been believed to support advanced cerebral functions such as complex emotional homeostasis. However, few studies provide causal link evidence with specific molecular and cellular identities. Here, using RNAscope, cell-type specific conditional knockout (cKO) perturbation in BL6/C57 mice, laser speckle contrast imaging, and mouse behavior assays, we demonstrated that the N-methyl-D-aspartic acid (NMDA) receptor noncore subunit NR2D is only expressed in cerebral arteriole smooth muscle cells (aSMCs) but not in peripheral aSMCs. Both aSMC-NR2D cKO and aSMC-NR2D+NMDA receptor subunit 1 (NR1) double cKO mice displayed a severe decline in functional hyperemia induced by whisker stimulation. In addition, the NR2D pathway was independent of previously demonstrated COX-2-PGE2-dependent mechanism and high-fat diet (HFD)-induced impairments in NVC. Caldesmon is a potential downstream protein in the NR2D pathway for NVC regulation. Notably, we demonstrated that NVC deficits caused abnormalities in complex emotional behaviors, such as anxiety-like behaviors (exhibiting increased defecation and urine), reduced curiosity and decreased fear instinct (displaying less fear of aggressive CD1 mice). Furthermore, fear-response gene c-FOS expression in the amygdala neurons was attenuated in aSMC-NR2D knockout mice after response to acute stresses. In contrast, its expression level remained unchanged in the non-fear-related cerebral regions such as the piriform cortex and hippocampus. These findings demonstrated that inadequate functional hyperemia impaired cerebral complex emotional functions and suggested a co-existence of anxiety and fearlessness in single individuals. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.12.528175v1?rss=1 Authors: Kume, M., Ahmad, A., DeFea, K. A., Vagner, J., Dussor, G., Boitano, S., Price, T. J. Abstract: Background and Purpose: Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a common, dose-limiting side effect of cancer therapy. Protease-activated receptor 2 (PAR2) is implicated in a variety of pathologies, including CIPN. In this study, we demonstrate the role of PAR2 expressed in sensory neurons in a paclitaxel (PTX)-induced model of CIPN in mice. Experimental Approach: CIPN was induced in both PAR2 knockout/WT mice and mice with PAR2 ablated in sensory neurons via the intraperitoneal injection of paclitaxel. In vivo behavioral studies were done in mice using von Frey filaments and the Mouse Grimace Scale. We then examined immunohistochemical staining of dorsal root ganglion (DRG) and hind paw skin samples from CIPN mice to measure satellite cell gliosis and intra-epidermal nerve fiber (IENF) density. Pharmacological reversal of CIPN pain was tested with the PAR2 antagonist C781 Key Results: Mechanical allodynia caused by paclitaxel treatment was alleviated in PAR2 knockout mice of both sexes. In the PAR2 sensory neuronal conditional knockout (cKO) mice, both mechanical allodynia and facial grimacing were attenuated in mice of both sexes. In the dorsal root ganglion of the paclitaxel-treated PAR2 cKO mice, satellite glial cell activation was reduced compared to control mice. IENF density analysis of the skin showed that the paclitaxel-treated control mice have a reduction in nerve fiber density while the PAR2 cKO mice had a comparable skin innervation as the vehicle-treated animals. Similar results were seen with satellite cell gliosis in the DRG where gliosis induced by PTX was absent in PAR cKO mice. Finally, C781 was able to transiently reverse established PTX-evoked mechanical allodynia. Conclusions and Implications: Our work demonstrates that PAR2 expressed in sensory neurons plays a key role in paclitaxel-induced mechanical allodynia, spontaneous pain and signs of neuropathy, suggesting PAR2 as a possible therapeutic target in multiple aspects of paclitaxel CIPN. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Nolan Bushnell - Inventor & Entrepreneur What do the Atari company and Chuck E Cheese have in common? Well, besides offering a lot of options for entertainment, it might surprise you to learn that they were both founded by the same man–a Silicon Valley entrepreneurial legend who holds the distinction as first and only person to ever hire Steve Jobs. But rather than resting on his achievements, he's chosen to spend the autumn of his life (his words, not ours) trying to understand how gamifying the learning process could supercharge the educational experience for the next generation. He'll help us consider    How can we create the school of the future? A conversation with Nolan Bushnell, on this episode of Lead With a Question. Guest Bio: In 1972 Nolan Bushnell created an industry when he founded Atari and gave the world Pong, the first blockbuster video game. Today his design credo—that games should be “easy to learn and difficult to master”—is inspiring a new generation of developers. A prolific entrepreneur, Bushnell has started more than 20 companies, including Chuck E. Cheese's Pizza Time Theater, Catalyst Technologies, the first Silicon Valley incubator, and Etak, the first in-car navigation system. In the process, he pioneered many of the workplace innovations that have made Silicon Valley a long-standing magnet for creative talent. Bushnell was the first and only person ever to hire Steve Jobs, which he details in his 2013 book, Finding the Next Steve Jobs. He is currently Chairman of ExoDexa, a gamified education company, CKO of Moxy, a “play to earn” game and token platform, and an advisor to companies in the gaming and esports spaces. Additionally, he sits on several Boards, focusing on games, gaming and robotics. A true icon of the digital revolution, Bushnell was named one of “50 People Who Changed America” by Newsweek. A biopic about Bushnell, tentatively titled “Atari”, was acquired by Leonardo DiCaprio's production company and is in pre-production. https://www.exodexa.com/ --------- Please like, subscribe, rate, and review! Every listener interaction helps others discover the show too! Learn about the work we're doing at Bravecore by visiting our website at Home - Bravecore To drop us a line, head over to Contact - Bravecore

In a Power Hour first, we interview fans! The Lovely Intoxicated Men are the right hand of RPW's Chet Gunderson, and they make a plea for his return, offering a reward of 24 cans of Old Style (23 by episode's end).Learn the origins of this Superfan group and what they're planning next!

Professional services environments are stressful. Among the myriad of items to be juggled each day, you must manage workloads, managing the capacity of employees -  what kind of work & how frequently work is allocated.  How well this aspect is managed will impact performance, productivity, DEI, and retention. As part of our startup series, we speak with William Dougherty, Co-Founder of Capcity, a legal tech tool that looks to improve the allocation of work.In the episode, we'll discuss (numbers are time markers): What is Capacity → 1.48 How is work allocated → 3.09 Issues with the current approach to work allocation → 4.24 What if nothing changes → 5.48 Capacity management vs. work allocation → 12.31 Getting buy-in to effect change → 17.02 The business impact of attrition → 21.46

These are the new kids on the block as far as Shrap is concerned. Ado Veli Podcast Season 10 Episode 22, which is episode number 256. Get Ado Veli Podcast Merchandise here: https://adovelipodcast.hustlesasa.shop/ Tracklist Juicee Mann ft Nare - Safi 0:00:00 Juicee Mann ft CKO and Nare - Kilipesa 0:02:37 Bigg Friz ft CKO - Mfanyikazi 0:05:12 Groovy Jo - Straight 0:07:40 Munyax ft CKO and Juicee Mann - CAP 0:09:45 Bigg Friz ft CKO - Alfajiri 0:13:48 DJ Mawinch ft Jovie Jovv, Jodye Faneto and Skinny Gean - DHL 0:16:11 CKO - Marangapi 0:19:24 DJ Mawinch ft Jovie Jovv, Jodye Faneto and Skinny Gean - No Hook 0:21:40 Jodye Faneto ft Groovy Jo - Gang 0:23:28 Jodye Faneto - WYKAT 0:26:11 Bigg Friz ft Kelmah and CKO - Everything 0:29:00 Juicee Mann ft Munyax. Nare and Boutross - Keja 0:31:50 Boutross ft CKO - Peter Marangi 0:34:41 Thayu Mwas and Dez - Bado 0:37:21 Skinny Gean ft Jodye Faneto - Keys 0:39:05 Thayu Mwas ft Groovy Jo - Dent 0:42:23 Boutross ft Jovie Jovv and Bigg Friz - Mteja 0:44:13 Juicee Mann ft Nare - Unanimaliza 0:47:55 Munyax ft Nare and Juicee Mann -Toa Form 0:51:54 Munyax ft CKO, Arif and Wamz - Besha 0:55:44 Boutross ft Ndovu Kuu and CKO - Sweety 0:58:22 Boutross ft Munyax - Mwanangu 1:01:36 Groovy Jo - Feelin' It 1:04:35 Skinny Gean - Mang'aa 1:07:00 Listen to Ado Veli Podcast on; Apple Music, iTunes, Spotify, Boomplay, Google Podcasts, Mixcloud, TuneIn and Stitcher https://smarturl.it/adovelipodcast Tune in, listen and share your thoughts on social media with our official hashtag #AdoVeliPodcast. Follow us on; Facebook Page: https://www.facebook.com/penninah.wanjiru.902 https://www.facebook.com/ADOVELl/ Twitter: https://twitter.com/penninahwanjir1 https://twitter.com/AdoVeliRadio Instagram: https://www.instagram.com/penninah_wanjiru/ https://www.instagram.com/adoveli/ Email: adoveli7@gmail.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.08.515614v1?rss=1 Authors: Looser, Z. J., Ravotto, L., Jung, R. B., Werner, H. B., Ruhwedel, T., Moebius, W., Bergles, D. E., Barros, L. F., Nave, K.-A., Weber, B., Saab, A. S. Abstract: The integrity of myelinated axons relies on homeostatic support from oligodendrocytes (OLs), which is essential for brain function. However, the mechanisms by which OLs detect axonal spiking and rapidly control axon-OL metabolic coupling are largely unknown. Here, we combine optic nerve electrophysiology and two-photon imaging to study activity-dependent calcium (Ca2+) dynamics in OLs and metabolite fluxes in myelinated axons. Both high-frequency axonal firing and extracellular potassium (K+) elevations trigger a fast Ca2+ response in OLs that is facilitated by barium-sensitive, inwardly rectifying K+ channels. Using OL-specific Kir4.1 knockout mice (Kir4.1 cKO) we now demonstrate that, in addition to being crucial for K+ clearance, oligodendroglial Kir4.1 regulates axonal energy metabolism and long-term axonal integrity. Before the manifestation of axonal damage, we observed reduced glucose transporter GLUT1 and monocarboxylate transporter MCT1 expression in myelin of young Kir4.1 cKO mice, suggesting early deficits in metabolite supply to axons. Strikingly, we found lower resting lactate levels and activity-induced lactate surges in optic nerve axons of young Kir4.1 cKO mice. Moreover, both axonal glucose uptake and consumption were hampered in the absence of oligodendroglial Kir4.1, uncovering a new role of OLs in regulating axonal glucose metabolism. Our findings reveal a novel model of axon-OL signaling and metabolic coupling in which OLs detect high-frequency axonal activity through K+ signaling, which is critical in adjusting the axon-OL metabolic unit and in preserving long-term axonal health. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.30.514412v1?rss=1 Authors: Fain, C. E., Zheng, J., Jin, F., Ayasoufi, K., Wu, Y., Lilley, M. T., Dropik, A. R., Wolf, D. M., Rodriguez, R. C., Aibaidula, A., Tritz, Z. P., Bouchal, S. M., Pewe, L. L., Urban, S. L., Chen, Y., Chang, S.-Y., Hansen, M. J., Kachergus, J. M., Shi, J., Thompson, A. A., Harty, J. T., Parney, I. F., Sun, J., Wu, L.-J., Johnson, A. J. Abstract: CD8 T cells are implicated in the neuropathology of human cerebral malaria. Using human data as well as the Plasmodium berghei ANKA (PbA) model of experimental cerebral malaria (ECM), we sought to define contributions of brain endothelial cell MHC class I antigen (Ag) presentation to CD8 T cells in this pathology. We crossed novel H-2Kb and H-2Db LoxP mice to Cdh5-Cre mice to achieve targeted deletion of discrete class I molecules on endothelium. RNA transcriptomes of brains during PbA infection are differential between H-2Kb and H-2Db expressing mice, highlighting differential regulation of neuropathogenesis. Distinct patterns of disease onset, CD8 T cell infiltration, targeted cell death, and regional BBB disruption and vascular leakage are observed. Strikingly, ablation of H-2Kb or H-2Db from brain endothelial cells resulted in diminished interactions of T cells with brain vasculature and lessened infiltration of activated CD8 T cells, resulting in prevention of blood-brain barrier (BBB) disruption, CNS vascular leakage and death. Overall, endothelium-specific conditional knockout (cKO) mice were protected from development of ECM resulting in survival of the mice. These data show the first in vivo evidence that interactions of CD8 T cells and cognate peptide:MHC on brain endothelium regulate development of ECM neuropathology. Therefore, targeting MHC class I interactions therapeutically may hold potential for treatment of cases of severe malaria. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Time for another rendition of everyone's favorite CKO classic — a GRWM! For the makeup look, I did a double brown-toned look focused on the eyes and lips. Head over to my Instagram to see the finished look and the video (it should be up by 11:00 A.M. EST on Oct 13, 2022)! Visit the landing page for more information here: https://bit.ly/cutekindof PRODUCT LIST (All Affiliate Links): Marc Jacobs Under(cover) Blurring Coconut Face Primer: Discontinued Elizabeth Mott Thank Me Later Eye Shadow Primer: https://shopstyle.it/l/bMRPa Merit The Minimalist Perfecting Complexion Foundation and Concealer Stick: https://shopstyle.it/l/bMRPe Pat McGrath Labs Skin Fetish: Sublime Perfection Concealer: https://shopstyle.it/l/bGp5L Kosas Revealer Super Creamy + Brightening Concealer: https://shopstyle.it/l/bMRPh Charlotte Tilbury Instant Eye Palette - Pillow Talk: https://shopstyle.it/l/bKemN KISS Looks So Natural False Eyelashes in “Sultry”: https://shopstyle.it/l/bMRPt L'Oreal True Match Lumi Glotion: https://shopstyle.it/l/bMROw NARS Climax Mascara: https://shopstyle.it/l/bMRQe TheBalm Bahama Mama Bronzer: https://shopstyle.it/l/bMRQl Hourglass Ambient Lighting Powders in “Diffused Light, Dim Light and Iridescent Light”: https://shopstyle.it/l/bMRPL Hourglass Ambient Lighting Blush in "Mood Exposure" : https://shopstyle.it/l/bMRQv Makeup By Mario MoistureGlow Plumping Lip Serum in “Mocha Glow”: https://shopstyle.it/l/bMRQx Half Magic Sculptitude Lip Liner in “I Have Needs and I'll Pray For You”: https://bit.ly/3ECaDE4 Let's Be Friends! Instagram: @cutekindofpodcast Pinterest: @cutekindofpodcast MORE OF CUTE, KIND OF: #99: Product Reviews and Recommendations V (HAIR); Apple Podcasts, Spotify, Anchor #107: My favorite photo editing apps!; Apple Podcasts, Spotify, Anchor

The guest this week are co-founders of New York-based Priori Legal.  Basha Rubin, the company's Chief Executive Officer, and Mirra Levitt, the Chief Product Officer, met as classmates at Yale Law School and found Priori. Earlier this year, they announced a funding round of $15 million.  Priori works with in-house legal teams to connect legal departments with the right outside counsel for projects globally, saving them time and money. We discuss Legal Tech trends, their origin story, raising funds a Women Founders, and the secret sauce for successful legal teams.

Legal operation teams have been increasing in popularity. In this episode, Liz Lugones and Sumi Trombley from Uplevel Opsshare why Legal Ops teams matter, why you should care, and how to leverage them to level up your legal team (in-house and at firms). Uplevel Ops are offering a complimentary 30-minute consultation, you can find more here.  In the episode, we discuss: (03:12) Why should you care about legal operations (LegalOps)? (04:21) Law school vs. practice (08:12) Enabling fail-fast thinking in legal teams (11:11) It's not just about technology  (16:32) Embedded in the organization (21:25) Creating space for creativity and ideas (28:38) Celebrating success (30:49) Gaining trust (34:25) Shifts in legal operations Article referencedStriving for Imperfection: The Complicated Relationship of Lawyers and Project Management by Sumi Trombley & Liz LugonesKey quotes(edited for a better reading experience)People and lawyers want to be able to solve the problems of their clients, but in doing so, and what's the best way to do it doesn't always mean here's the legal answer. Maybe they're looking for optionality, a strategic partner, or they are looking to reduce the risk. Whatever the answer is,  you have to talk to your business counterparts to be able to figure that out.The thing that Liz hit on was 'the therapy' - that aspect of legal operations is the bridge from getting to, I know the legal answer, to how do I deliver it to my client in a way that makes them happy and feel like they have the best result. Sometimes you're not likely to go to the person who's giving you the advice and say, "I don't like the way you're giving me the advice." You need a buffer, and that's the legal operations buffer. With that in place, you can express the problem. The legal ops professional can go share it as the buffer: "I'm generally hearing from these people, And here's what I suggest we start to do to help facilitate."Often, I believe people in the profession think that legal operations are putting technology in, right? Or you're putting a process in. And I feel like the conduit that legal offspring is legal ops is not all those things. Legal ops is a mindset that needs to happen in the culture of the org, for the department to get better. The buffer is the data coming out of the technology you put in there.About the guestsElizabeth "Liz" Lugones, COO/Senior Advisor, UpLevel OpsLiz has built and managed Legal Operations teams in various industries in both public and private companies over her 20+ year career. She excels in global project management and business reengineering, with particular expertise in process improvement, change management, cross-functional collaboration and team building, but her true passion is helping others find their own strengths and talents and harness them for the value of all.Before joining UpLevel, Liz served as the Senior Director of Legal Operations at WeWork. Prior to WeWork, Liz served as Director of Legal Operations at a diverse range of companies, including UnitedLex, DXC Technology, Becton Dickinson, and MetLife. She also worked at Citigroup as Manager, Strategy and M&A.Liz holds a BA in Political Science and Journalism from Rutgers University, is certified in Lean Six Sigma and fluent in Spanish. She is based in New Jersey.Sumi Trombley, Senior Advisor, UpLevel OpsSumi Trombley practiced in law firms and in-house legal departments for more than a decade before coming to UpLevel Ops. Sumi previously served as Director, Legal at enterprise legal services provider Marshall Denning, LLC, where she managed and trained a team of junior and senior attorneys and developed and implemented resource optimizing processes for RFPs and pre-litigation disputes. She is known for her ability to provide strategic guidance and cost-effective solutions.Prior to joining Marshall Denning, Sumi was Legal Counsel at Hewlett Packard Enterprise, serving as a de facto general counsel to top enterprise IT outsourcing accounts. She started her legal career at the law firms of Paul Hastings LLP in New York and Latham & Watkins LLP in DC, practicing corporate finance and securities law.Sumi holds a JD from Northwestern University Pritzker School of Law, and a BA in Political Economy from Georgetown University. She is based in Maryland.

To supplement the release of the Fringe Legal no-code report, which provides 100s of hours of market research in 6-min, we speak with Jackson Liu, Chief Commercial Officer at Neota, about the state of no-code in legal. During the conversation, we discuss: How firms are using no-code tools Leveraging no-code tools as a competitive advantage Focusing on the customer journey and adoption for long-term success No-code challenges Future of no-code You can read the full No-code report at www.fringelegal.com/no-code-report/

On this episode with speak with Kai Jacob  - Partner at KPMG and Co-founder of Liquid Legal Institute - about digital transformation and designing the future of law. In the episode we cover (min.seconds): Introduction -> 0.20 Enthusiasm vs adoption of technology -> 1.56 Founding the think thank -> 3.24 Facilitating cross collaboration -> 5.06 Distributing projects equitably -> 6.04 Designing the future -> 10.14 Mental wellbeing -> 13.52 Skills for future lawyers -> 21.54 Being embedded with customers -> 27.12 Highlights from the episode What is Liquid Legal InstituteWe consider ourselves a collaboration community of doers. So we like to do stuff, everything that we tackle and that we focus on should lead very fast to a result. Not just talking, doing.Lack of collaboration in the legal market...they helped us really to nail down the question of 'why is the legal market not collaborating'? That was a very interesting question because we are all sharing, we all do this together. We even have this concept of Co-opetition. Then why not work with competitors on something like setting standards? Why should we, in the legal market, cooperate? We are all making good money with this private wisdom that we have and built up over time. So why should we share? We also believe that without sharing, without creating true standards in the market, it will take ages to go through this digital transformation.Struggling with digital transformationWe see that people are really struggling with digital transformation. They first don't understand why all this is happening. They're missing the digital mindset.The idea that digital transformation is something positive. They do not get the link back to legal because, they are thinking that what we do is something that's handcrafted; it's something that relies on very special knowledge.We do a perfect job of creating the perfect, beautiful contract that nobody else understands. We see beauty. And we see our role in protecting our company and defending our companies, defending our client's interests. It's just that the other side doesn't understand it.So the digital aspect is that we need to get more out of this dormant contract that's archived in the file cabinet somewhere. To make it valuable information, accessible for the digital company that we are working in.The whole idea of digital transformation is to make information that sits somewhere in an unstructured format, deep in contracts, more accessibleWe miss a huge opportunity for our profession to sit at the C-suite table and contribute to the overall goals of the enterprise. Second, everything moves so fast. We are overwhelmed with the speed of change. And we need to understand that change is constant and it will never go back to a slow motion mode. It will not happen. It will be fast. So we need to learn how to become adaptable, call it agile, call it whatever, but we need to adapt fast to a changing world. We need first to understand what is digital, and second how to deal with that in an agile working model.About Liquid Legal InstitueThe Liquid Legal Institute is an open and interdisciplinary platform for promoting a new way of thinking in the legal sector. Digitalization, new business models and technological innovations are currently changing all major industries worldwide. However, the legal sector has not yet benefited sufficiently from these trends. The Liquid Legal Institute was founded by seven experts from legal and business practice, design thinking, and computer science to close this gap.

Besties, we are celebrating 100 episodes of CKO today! This episode was a pain to edit and get up, but I am low-key feeling sentimental rn. If you are a fellow podcaster, writer, influencer, civilian, idk — please do this challenge and tag me (I wrote the questions below)!! I would love to see/hear/read your answers :) Also, a huge thank you to everyone who listens to this podcast. I started it for fun to stop myself from mentally spiraling, so I appreciate everyone who listens to me ramble every week. Link to Desi's video here Questions: Self-image then vs self-image now. X Social life then vs social life now. X Who you idolized then vs who you idolized now. X Personality then vs personality now. X Priorities then vs priorities now. X Goals then vs goals now. X Makeup game then vs makeup game now. X Fashion sense then vs fashion sense now. X Your obsessions then vs your obsessions now. X Handling hardships in life then vs handling it now. X Define yourself in three words then vs three words now. X Relationship status then vs. relationship now. X Visit the landing page for more information here Let's Be Friends! Instagram: @cutekindofpodcast TikTok: @cutekindof Pinterest: @cutekindofpodcast --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Lawyers and firms have long struggled to find the right way to price their services.The hourly billing model focuses on the amount of time spent on a matter, project, or case. This can often lead to inefficiencies and frustration for the lawyer and the client. Value based pricing is an alternative that takes into account the value of the service being provided rather than simply the time spent. It means that lawyers and firms are paid based on the results they achieve for their clients.The incentive becomes focused on getting better results. Value-based pricing can also help build trust and improve communication between lawyers and clients.However, that doesn't make pricing or pricing conversations any easier. In this episode, we go into the rabbit hole of pricing.  SUBSCRIBE AND REVIEW:  iTunes // Spotify // Pocket Casts // StitcherSpecial thanks to Paul Stroka of LexFusion for making the introduction to Keith.Episode content Introduction and summary ➡ 1.24 Power of buyer ➡ 4.30 Power of supplier ➡ 7.34 Elastic economic market ➡ 9.42 Price discrimination ➡ 13.14 Client sophistication ➡ 17.08 Inflation and pricing for specialized services ➡ 23.46 The next service delivery model ➡ 31.04 Here are some of our favorite takeaways from the episode (edited to be reading-friendly).Value of workOne of the things that get ignored in discussions with clients or in the clients' calculus and how they determine what they're getting for the bills they're paying is that there's never a very accurate way of measuring the value that was captured from the services, and what the outcome was.It's always what was that bill? That bill is high. Maybe you bought a company, in an M&A scenario, that had subsidiaries or locations in highly regulated, highly risky territories - where there's a ton more work to be done. It's not an apples-to-apples kind of company. So you don't look at what I got for the price I paid? You're just saying the bills are higher now.Price discriminationAb: How do you demonstrate that we're going to charge you X, and it's worth more than X to you as an outcome?Keith: Price discrimination is the short answer to that. Not everything is worth the same amount. By nature, and this is not any judgment or me trying to take a position on the actual value or the value of the practitioners doing this kind of work. But by nature, there's a spectrum of complexity, and the stuff that's really complex on the highly complex side tends to be more scarce. There is a more scarce supply of people who can do it.On the opposite side, on a more commoditized side or the more routine side - it's not as complex, and there are more options to avail yourself of to do that work.Client sophistication - apply the scalpel, not the hatchetMy particular role is to ensure that the firm is as profitable as possible and that we're making our clients as happy as possible in terms of service delivery models and getting the outcomes they want.The conversation with the client depends on the level of sophistication:I'd say architecting and implementing some of those solutions depends on the sophistication that the client or the person on the buy-side has. There are only so many levers in this business in terms of what I can do. It's all about service delivery models and the underlying economics. This isn't astrophysics. There are not huge, massively complex data jobs in most cases (there are some benefits to that in different scenarios).There are a couple of levers on who's going to do the work and how much they have to do, what's the cheapest way to do it, and what the outcome will be. How do those things correlate (the price to the product)? Having those conversations with people that understand that better is important.I've worked with several legal operations groups where they have the knowledge, the understanding, and the sophistication. Still, there's a gap in the level of influence they have over the in-house attorneys...Different sides of the table, same challenges:We have very similar challenges - in-house and the law firm side - as it relates to getting the lawyers to understand the economics, the process, and to engage attorneys with it - to really adopt it. As opposed to, 'Yeah, but I'm skeptical of that because I don't understand it. So let's just do it the old way.'Next service delivery modelWhere can I get efficiencies out of technology? Which is a hugely growing market, that's going to be the new paradigm shift. It's going to be a much more dynamic service delivery model...Given that we've got a shortage of supply of people with the requisite skills to do a lot of this work and that's why we have to charge more. They [the attorneys] also have been working ridiculous man hours, and that's why we have to pay more for that. On top of that, there are obviously the mental health and quality of life concerns which is why a lot of people leave the workforce.I've been trying to make the case, and we work with our innovation group a lot, too, with several different teams internally to say: 'if you don't want people burnt out, you want them to have a better level of work-life balance and job satisfaction. Don't force them to brute force their way through everything all the time.'If you can get 30% more productivity out of the same people and let them sign off at seven or eight at night and use some tool that scales their productivity and delivers efficiencies then do it. You still get the same outcome, you just don't have to have as much input to have the same output.Resources mentioned Off The Clock Podcast Porter's Five Forces and a deeper look at Buyer Power

Dnes sa rozprávam s filozofom a aktivistom Fedorom Blaščákom a tu je malá ochutnávka z tém a otázok, o ktorých sme hovorili.----more----   Čo je to filozofia a dokázala by nejakým spôsobom pomôcť populizmom zmietanému Slovensku? Kedy sa Slovensko rozdelilo na konzervatívny a liberálny tábor, ako z toho von a prečo by nemal byť konzervativizmus výhradne kresťanský? Prečo dnes každému odporúča prečítať si Huntingtonovu knihu The Clash of Civilisations a prečo je správne nazývať vojnu v Ukrajine kultúrnou vojnou? A neprevzal sa seba sekulárny štát náboženskú úlohu garantovať ľudskú dôstojnosť?   Pred samotným rozhovorom mi dovoľte môjho hosťa predstaviť.   „Fedor Blaščák je nezávislý konzultant, publicista a aktivista. Vyštudoval filozofiu na Univerzite Komenského v Bratislave. Zaoberá sa súčasnými dejinami a politikou pamäti, filozofiou, vzdelávaním a kultúrou. Samostatne zostavil knihy Engerau (2005, CKO) a Amnestie. Sloboda ako hrubá čiara za minulosťou (2019, Slovart).“ (Zdroj: SME) Súvisiace dávky:   PD#159: Rozhovor s Rastislavom Káčerkom, http://bit.ly/davka159 PD#146: Je interrupcia vždy vražda?, http://bit.ly/davka146 PD#39: Ako vznikla filozofia?, http://bit.ly/davka38 PD#28: Ľudská dôstojnosť, http://bit.ly/davka28     Použitá a odporúčaná literatúra: rozhovor s Fedorom Blaščákom na podcaste Ľudskosť, https://bit.ly/391cJAa Huntington, The Clash of Civilisations (2002), https://bit.ly/3aMpwqG Fukuyama, Identita (2019), https://bit.ly/3zp5FYY   ***   Baví ťa s nami rozmýšľať? Získaj extra obsah cez Patreon (https://bit.ly/PDtreon), podpor náš  ľubovoľným darom (https://bit.ly/PDdar) a čo tak štýlový merč? (https://bit.ly/mercPD) Ďakujeme!    

Leading teams during times of crisis presents a unique challenge. Many of which are multiplied when you are a startup and the team was only formed months ago. And then, overnight, everyone suddenly felt very fragile. It's a unique feeling and unique in a bad way because suddenly you have no idea what to do. And the feeling is that you're very lost.Yet, that is exactly the challenge that faced Alex Tsepko, CEO of Lawrina - a website that provides useful content and productivity tools for lawyers. The entire team for Lawrina was in Ukraine, and things changed overnight as the country was invaded. Lawrina CEO, Alex Tsepko, speaks about his experience leading a newly formed team through a sudden crisis - the invasion of Ukraine - and finding growth through a shared vision. In this episode, we cover (timestamps in parenthesis): Introduction (0:20) Ukraine as a hub for IT innovation (1:38) Experiencing unexpected crisis as a young organization (3:22) Leading through a crisis (6:08) Finding growth through a shared vision (11:57) Recognizing that it wasn't possible to continue doing anything the old way, Alex ensured that his team was safe and pivoted to continue working to execute their vision. The business went from a domestic play to having an international group with traffic growing 35%+ each month.As Alex shares, "it was not easy," but the team came together during a time when they felt fragile to build something they believed in.Alex Tsepko is the CEO of Lawrina.com. You can connect with Alex on LinkedIn.If you like the show, then I know you'll love the Fringe Legal newsletter which is full of interviews, articles, and reports to help Legal innovators like yourself learn how to put ideas into practice and find success. You can sign up for free at FringeLegal.com. 

It's a long road to build a successful knowledge management program, but it helps to hear what other organizations have done and their lessons learned along the way. This podcasts highlights advice on developing, optimizing, and sustaining a KM program from: Juanita Coyle, CT1 KMSO, U.S. Navy Ian Pfaff, CKO, U.S. Army Training and Doctrine Command Michael Prevou, Deputy CKO, U.S. Army Training and Doctrine Command Kelly Souders, CT1 Program Director, U.S. Navy Carrier Team One Allison Wilkins, Knowledge Management Director, Prudential Subscribe to us on iTunes or wherever you get your podcasts!

In this week's episode, we have curated a playlist featuring songs in late December and the month of January. Ado Veli Podcast season 09 episode 05, which is episode number 213. Tracklist Rkeii ft Kabuga And Mervyn Obiero - Keep Remix 0:00:00 Ekumbo ft Swahili Papi And B.Hobs - Genuine 0:03:30 LB (El Presidente) ft by a - Nasty 0:05:38 HR The Messenger - It Is What It Is 0:07:40 Tokyo Sauce ft Swahili And Jovie Jovv - Hio Bash 0:09:24 Iduzeer ft Mbogi Genje And Mr. Right Buruklyn Boyz - Mrazi Bulls#!t Remix 0:11:52 Ajay Buruklyn Boyz ft Big Yasa And Silverstone Barz - Bae 0:15:18 Natty - Yola 0:18:07 Majessty ft Groovy Jo - Spooky Season 0:19:57 Slimmkhalif - Cheki 0:22:11 Mbuzi Gang ft Katapilla And Silverstone Barz - Wah Wah 0:24:00 Chepkosgei - Bad News 0:28:33 Wakadinali - Eye Contact 0:30:33 Earlwin - Kakamega 0:34:56 Prxnce ft Boutross - Omoka 0:36:42 Sir Bwoy - Social Media 0:39:26 Asum Garvey ft Dez - Napata 0:42:55 Serro ft Mutoriah - Hold On To The Faith 0:45:40 Ethan Muziki - Tempted 0:47:54 Chris Kaiga ft Dai And Scar Mkadinali - Ongeza Debe 0:50:35 Munyax ft CKO, Arif And Wamz - Besha 0:53:09 Apesi ft Scar Mkadinali - Tema 0:55:43 Muhanjii ft Yo Alex And Josh Xtra - Horera 0:57:48 Mars Maasai - Too Strong 1:00:03 Danytox Intronix ft HR The Messenger - Legacy 1:02:24 Scar Mkadinali - Should Be 1:04:27 Chupee ft Domani Mkadinali - Vile Iko 1:06:36 Nu Fvnk - Fair Game 1:09:22 Elisha Elai - Mfalme 1:11:13 Wendy Kay ft Steph And Scar Mkadinali - My Way Remix 1:14:40 Listen to Ado Veli Podcast on; Apple Music, iTunes, Spotify, Boomplay, Google Podcasts, Mixcloud, TuneIn, Stitcher, Hearthis.at, audiomack and SoundCloud here; https://smarturl.it/adovelipodcast Tune in, listen and share your thoughts on social media with our official hashtag #AdoVeliPodcast. Follow us on; Facebook Page: https://www.facebook.com/penninah.wanjiru.902 https://www.facebook.com/ADOVELl/ Twitter: https://twitter.com/penninahwanjir1 https://twitter.com/AdoVeliRadio Instagram: https://www.instagram.com/penninah_wanjiru/ https://www.instagram.com/adoveli/ Email: adoveli7@gmail.com Host: Pesh And Ado Veli

In this week's episode, Pesh and Ado Veli have picked 10 songs each from 2021, which they felt made a mark in 2021. On top of the 20 songs, they added 2 songs each from Kenyan musicians to watch out for in the year 2022. Ado Veli Podcast season 09 episode 02, which is episode number 210. Tracklist Mi$taK ft Oukoseason - Vile Na Bang 0:00:00 Double Trouble - Smoke 0:02:30 Asum Garvey ft Trabolee - Pongeza 0:04:47 Danytox Intronix ft Malia, Donn J & Katapilla - Kanyagia 0:07:15 Maandy - Hivi Na Hivo 0:11:49 Wakadinali ft Sir Bwoy - Geri Inegi 0:22:33 Brandy Maina - Maryjane 0:26:59 Breeder LW ft Ndovu Kuu & Trio Mio - Pattern 0:29:13 Steph - On Demand 0:33:10 Vallerie Muthoni ft Silverstone Barz - Take It Over Der 0:34:35 Chepkosgei ft Khaligraph Jones - Okas Iit 0:47:55 Silverstone Barz ft Boutross - If Its On 0:51:32 Jakk Quill ft Steph Kapela - Gone 0:54:21 Boutross - Shrap Over The Rest 0:56:35 Natty - Iraq 0:58:51 Groovy Jo - Ego 1:10:50 Da Vaji - Big Dawgs 1:12:24 Jovie Jovv ft Swahili Papi & Prxnce - Shrill Freestyle 1:15:04 Big Yasa - Cold 1:17:34 Buruklyn Boyz - Dream Ya Kutoka Kwa Block 1:20:00 Munyax ft CKO and Juicee Mann - Cap 1:37:34 Young NC - Mbele Yao 1:41:38 Musa Kiama - Imani 1:43:30 Wanavokali - Nitangoja 1:45:47 Listen to Ado Veli Podcast on; Apple Music, iTunes, Spotify, Boomplay, Google Podcasts, Mixcloud, TuneIn, Stitcher, Hearthis.at, audiomack and SoundCloud here; https://smarturl.it/adovelipodcast Tune in, listen and share your thoughts on social media with our official hashtag #AdoVeliPodcast. Follow us on; Facebook Page: https://www.facebook.com/penninah.wanjiru.902 https://www.facebook.com/ADOVELl/ Twitter: https://twitter.com/penninahwanjir1 https://twitter.com/AdoVeliRadio Instagram: https://www.instagram.com/penninah_wanjiru/ https://www.instagram.com/adoveli/ Email: adoveli7@gmail.com Host: Pesh And Ado Veli

Owner of CKO Newark, Tanya Serrano shares how her personal journey inspired her to open a CKO location in Newark, how fitness and therapy connect, trusting the process, getting #thickfit and more!

Vishal Agnihotri is the Chief Knowledge Officer at Hinshaw & Culbertson LLP, a national law firm with over 400 lawyers. Hinshaw & Culbertson LLP delivers a sophisticated legal practice with emphasis in litigation, consumer financial services, environmental law, and much more. As the CKO, Vishal oversees the firm's knowledge management, legal product management, and research services.  Before joining Hinshaw & Culbertson LLP, Vishal held a variety of executive leadership positions, including Chief Knowledge Officer at Akerman LLP and Associate Director of Global Knowledge at KPMG. She has also served as an Advisory Board Member for Rutgers Business School and Bloomberg BNA. In this episode… Why does knowledge management matter in the legal industry? How can legal professionals effectively navigate the spread and growth of technology in 2021 and beyond? As Vishal Agnihotri says, it's all about wielding the right information at the right time.  As a Chief Knowledge Officer in the legal field, Vishal has seen technology grow exponentially in the past two decades. She explains that information is power — as long as you know how to wade through the excess to find the right data. Now, she's here to share her expertise on knowledge management and explain how you can leverage the information explosion happening at this very moment. On this exciting episode of The Lawyer's Edge, Elise Holtzman talks with Vishal Agnihotri, the Chief Knowledge Officer at Hinshaw & Culbertson LLP, about how to navigate the spread of technology and information overload in the legal field. They discuss why knowledge management is essential for lawyers, how to adapt to ever-evolving technology, and her tips for leveraging data to gain a competitive advantage in your field. Stay tuned! 

Rich Rosso he's been an entrepreneur and an intrepreneur in varied industries, finding a home in fitness and weight loss 20 years ago. Rich has served as the COO of CKO, the popular kickboxing franchise for the last 10 years. For more info on The Business Side of Fitness visit: www.vanessaseveriano.com/podcast Connect with Vanessa on LinkedIn: https://www.linkedin.com/in/vanessaseveriano/ Want to be a guest or have a question about your business? Drop us a line hello@vanessaseveriano.com

Joseph's story is one of determination, hard work and taking chances. CKO Kickboxing was originally formed in Hoboken, NJ as “Take It To The Max” in November, 1997 by Joseph Andreula. Joseph designed and created the intense workout, which was the first of its kind. CKO became so popular in Hoboken, that by 2004, nine additional locations opened throughout NJ and NY. In the summer of 2005, CKO opened the doors to its second Hoboken gym. CKO has a massive army of devoted followers and has been recognized in countless national fitness magazines and television programs such as NBC's The Today Show. For any entrepreneur who has had doubts you need to hear this story! https://www.ckokickboxing.com/

We have one of our low back pain patients, Juliana Magnifico shared with us her story.Juliana is a CKO kickboxing coach as well as a nutrition coach. She truly understands the field of fitness and has been part of it for the past 8 years. She came to us in April to address the nagging low back pain and sciatica that prevented her from coaching, working out, and living her life.We talked about - her journey into the fitness world- her injury and recovery- how her injury affected her mental wellbeing and her sense of self- how she was able to stay focused and positive- what she would like to change about the healthcare field and her negative experience with MRI and x-ray- her experience with Dr. Matt Fung at MyokinetixWe hope you guys enjoy this episode.Get connectedwww.myokinetix.comFacebookInstagramTwitterJoin Our Tribe on Facebook to grow together and ask questionsMusicDanger Storm by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/4985-danger-stormLicense: http://creativecommons.org/licenses/by/4.0/

We Dive into the everyday operation of CKO, we talk clients, decoy spreads, different views and opinions about this sport and overall just a couple guys talking about waterfowl hunting. We also throw in a couple good stories too!

Charlie, owner of CKO Jersey City, CKO Bayonne, and Prosper Private Training joins us to talk about how to stay motivated to workout and how exercise helps reduce stress. Connect further with Charlie: Instagram: https://instagram.com/charlie.ko Website: https://www.charliekofitness.com If you're in NJ check out his CKO gyms: CKO Jersey City: 150 Bay St, Jersey City, NJ CKO Bayonne: 744 Broadway, Bayonne, NJ Prosper Training: 150 Bay St 2nd Flr, Jersey City, NJ --- Support this podcast: https://anchor.fm/blissfully-balanced-life/support

Welcome to Evolving KM, a podcast where we discuss how Knowledge Management is progressing and the impact that's having on KM professionals. In each episode, we interview people who have either worked in or on the periphery of Knowledge Management We get their perspective on how this profession is evolving to meet the shifting demands of legal service delivery. We hope you enjoy this episode! Guest: In this episode, we speak with three partners from Fireman & Company, a premier legal knowledge management consulting firm: Joshua Fireman is the founder and president of Fireman & Company. He is a former practicing lawyer and advises law firms on knowledge management, change management and firm strategies. In addition to consulting, Joshua is a frequent speaker on these topics.   Ron Friedmann is a pioneer in practice support, legal process improvement and knowledge management. He is also a leader in alternative sourcing models. Ron is a prolific writer and tweeter, and we recommend following him at Prism Legal and on Twitter. During the podcast, we reference his article on multidisciplinary teams, which you can find here.   Tom Baldwin brings a focus on team building, user experience and attorney working practices to drive practice efficiencies and profitability. Before becoming a consultant, Tom has large law firm experience as both CIO and CKO. Joshua, Ron and Tom collectively have decades of wide-ranging experience in the legal industry, and we always love listening to their thoughts. Join us as we discuss with them the changes in the legal industry, particularly challenges and opportunities for knowledge management programs. They review the evolution of KM from 1.0 to 2.0 to 3.0, from a cost center to a revenue driver, and from being useful to being critical. They also give advice for those looking to enter the profession or to develop their skills. Hosts: Gwyn McAlpine oversees the knowledge management program at Perkins Coie LLP, an international law firm with 1,000 lawyers in 19 offices. Gwyn's focus is on creating value for clients by enabling attorneys to practice law more efficiently and collaboratively. In addition to more traditional KM initiatives, KM at Perkins Coie includes library and research services, internal and external collaboration, and AI and expert systems. Gwyn practiced corporate law for 10 years before fully transitioning to knowledge management.   Amy Monaghan is the Practice Innovations Manager within the knowledge management group at Perkins Coie LLP. She works side-by-side with practice groups to further KM initiatives, particularly those involving artificial intelligence systems and other advanced technologies, such as document assembly, logic systems, workflow tools and contract analysis tools. Previously, Amy was in a similar role at Chapman and Cutler LLP.

When Scott Rechtschaffen thinks “there has to be a better way,” he creates that better way. As a shareholder and later CKO at Littler, Scott has implemented outside-the-box solutions to a number of long-standing problems in legal practice. Find out how he eliminated the annoyance of firmwide RFI emails, made training on workplace regulations actually fun, and more.