Podcasts about M1

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

It's developer conference season, and one of the themes so far has been big swings at AI apps. We've seen Gemini Spark, Microsoft Scout, and so many other attempts to figure out what people, and companies, actually want their AI to do. Nilay and David discuss their experiences with the apps, before turning to Nvidia CEO Jensen Huang's vision for the AI-filled laptop of the future. Finally, in the lightning round, it's time for the Hype Desk, Brendan Carr is a Dummy, a deeply dumb Meta hack, and the future of a favorite VR game. Further reading: ⁠Testing Google's Gemini Spark AI agent: it's incredible, and creepy ⁠ ⁠Gemini's new AI agent is about as good as Google's demo ⁠ ⁠Microsoft Scout is a new AI personal assistant built on OpenClaw ⁠ ⁠Microsoft's Project Solara is an OS for AI agent gadgets ⁠ ⁠As AI gets better, it reveals an empty promise ⁠ ⁠Let us filter AI slop, you cowards⁠ ⁠Microsoft and OpenAI broke up — now they're ready to fight ⁠ ⁠These are the first Nvidia RTX Spark laptops ⁠ ⁠This is the Microsoft Surface Laptop Ultra with Nvidia RTX Spark ⁠ ⁠A first look at Microsoft's Surface Laptop Ultra and Surface Dev Box⁠⁠ ⁠ ⁠Nvidia is already planning N2X and N3X chips — the goal is the Star Trek computer ⁠ ⁠This could be Windows' M1 moment — but expect it to cost a ton ⁠ ⁠Computex 2026: All the news and announcements ⁠ ⁠Meta's own AI was exploited to hijack Instagram accounts⁠ ⁠Apple's strategy for smart glasses is the same as for smart watches ⁠ ⁠It sure seems like the Vision Pro isn't getting upgraded for a while — if ever.⁠ Subscribe to The Verge for unlimited access to theverge.com, subscriber-exclusive newsletters, and our ad-free podcast feed.We love hearing from you! Email your questions and thoughts to vergecast@theverge.com or call us at 866-VERGE11. (Timestamps are approximate.) 00:01:00 Intro 00:03:00 New Verge Merch Drop 00:09:00 Gemini Spark Test Drive 00:13:00 Privacy Tradeoffs Debate 00:21:00 Software Brain Pushback 00:36:00 Jensen Huang Computer Future 00:39:00 Microsoft Build Reality Check 00:41:00 Nvidia Spark Recall 00:42:00 Microsoft Badge Agents 00:54:00 Escaping Apple Tax 00:57:00 Wearables Walled Gardens 01:05:00 Hype Desk 01:06:00 Bond Game Streaming 01:09:00 Summer Games Fest 01:11:00 State of Play Highlights 01:11:00 God of War 01:14:00 Wolverine Gore Talk 01:15:00 Widows Bay 01:17:00 Lightning Round 01:17:00 Brendan Carr is a Dummy 01:26:00 Apple Glasses Rumors 01:36:00 Privacy Backlash Risk 01:38:00 Meta AI Hack Fiasco 01:43:00 Supernatural Returns 01:47:00 Wrap and Next Week Learn more about your ad choices. Visit podcastchoices.com/adchoices

出演者： miko、quim 配信ペース： 隔週 番組時間：89分10秒 ♯本番組はリモート収録です。 ♯収録時環境の影響により、全体的に聴き取り辛くなっております。 　申し訳ございません。 隔週に1回お届け。mikoラジ、第398回です。 労働は害悪でおなじみの我さん。 今週もハードでデスで笑いが悪い意味で止まらない模様。 しがないさんも驚きの隈……。 チーム我等の明日はどうなる?! 最後までごゆるりとお楽しみくださいませ。 ♯途中で色々とノイズ等入りますが、収録時のものです。 　ご安心ください、お手持ちの機器は正常です。 大変な絵 https://x.com/radio_4649/status/2059720447147843593?s=20 ・おとらってRECORD 公式サイト n-remix.com/otolatte/ ↑『おとらって10thライブ KUWANA』に参加予定の方は、 　「来場予約はこちらから」からご予約を！ 開催日／2026.8.23(日) 　第一部　OP11:30　ST12:00 　第二部　OP14:40　ST15:00 //////////////////// VOICEVOX:ずんだもん VOICEVOX:四国めたん //////////////////// -------------------- ●お便り募集中！ mikoラジでは以下の内容でお便りを募集中です！ ・ふつおた 　／普通のお便り、お待ちしています！ ・mikoは大変な絵を描いていきました 　／miko画伯に描いて欲しいお題をお待ちしています！ ・メシヲコエテ 　／料理人・mikoに教えて欲しいレシピをお待ちしています！ bit.ly/2GAWjyv 投稿フォームからラジオに投稿が出来ます！ コーナー名を選び、メッセージ・ラジオネーム・お所を入力して、 どんどん送ってください！　お待ちしています！！ ------------ 本ラジオのメインパーソナリティーである「チーム我等(miko/quim)」、 それぞれ以下個人サークルにて活動中です。 ・miko：miko ・quim：SHIGANAI RECORDS（ shiganai.com/ ） 活動詳細については、上記HPの他 各人のブログ/twitter等にて随時告知しておりますので、チェックしてみてください！ ・みころぐ。(mikoのブログ)（ ameblo.jp/miko-nyu/ ） ・@ mikonyu(mikoのtwitter)（ twitter.com/mikonyu ） ・@ quim(quimのtwitter)（ twitter.com/quim ） --- その他の活動については、以下のとおりです！ -- チーム我等がメインクルーとして活動していた「アルバトロシクス（ albatrosicks.com/ ）」、 これまでリリースしたCDは、イオシスショップ（ iosys.booth.pm/ ）にて頒布しております。ご興味ある方は是非！ ---------- ☆2026年5月IOSYSはいてない.comパワープレイ楽曲 M1. One Era feat. DD"ナカタ"Metal Produced by RoughSketch Vocal by DD"ナカタ"Metal 音楽ジャンル：Hardcore 収録アルバム：NBCD-052 20 Years Of RoughSketch: Golden Best & Remixes 2026 2026・4・26 Release https://notebookrecords.net/discographyportal.php?cdno=NBCD-052 積み重ねた『ジャパニーズ・ハードコア』を貴方に クリエイター「RoughSketch」の活動20周年を記念した2枚組アルバム。 書き下ろし新曲を含めたベストアルバムに加え、ディスク2には活動の中で出会った日本全国各地のトラックメイカーによるRemixが集結！ CD特典コンテンツとして2026年3月8日に行われた6時間ライブセットの音源をフルでダウンロード可能！

In the final episode of the 2026 Boot Camp series, Paul Merriman sits down with Chris Pedersen and Daryl Bahls to tackle the last fork in the road every investor faces: how to and how much automation to use. After all the boot camp decisions — stocks versus bonds, which equity asset classes, how much fixed income, how to handle contributions and withdrawals — the final question is how much of the day-to-day management you should hand off to a tool, and which tool is right for you.Chris walks through how M1 Finance “pies” let buy-and-hold investors put their portfolios on autopilot: automated contributions, on-the-fly rebalancing as new money comes in, fractional shares, and one-button rebalancing. He explains the pre-configured Merriman portfolios — the Ultimate Buy and Hold, Worldwide and US Four-Fund, All Value, All Small Cap Value, and the Aggressive Target Date glide path in five-year increments — and an important limitation: once you grab a pie, there’s no live link back to the source, so website updates won’t change your account.Paul then makes the case for Fidelity’s Basket Portfolios as an alternative, especially for anyone uneasy about moving large sums to a younger company. He covers the flat $4.99-per-month fee regardless of account size, eligible account types, the TFLO short-term Treasury workaround for holding cash, and why Fidelity may fit investors already in the Fidelity ecosystem. The team compares trading windows, account minimums and how each firm counts the $10,000 threshold, and Daryl shares that M1 has grown from about $1 billion in 2020 to roughly $12.5 billion in assets under management.The conversation closes with practical guidance on mixing and matching Sound Investing portfolios, the question everyone’s asking — “how long do I have to wait for small cap value?” — a reminder not to flail or chase recent performance, why the 10-fund Ultimate Buy and Hold strategy still stands, and a clear explanation of the move from AVUS to AVLC and where AVSC fits.CHAPTERS00:00 - Intro03:10 - M1 Finance13:45 - Fidelity Baskets24:27 - Portfolio Combos29:55 - When to Change Allocations42:44 - AVLC vs. AVUS45:15 - OutroLINKS:Sound Investing Portfolio PiesM1 Finance Pie Tutorial (Mobile App)M1 Finance Pie Tutorial (Web Interface)

https://youtu.be/sUyjA0muVgM Tom Kirkham, Founder and CEO of Kirkham IronTech, believes business should create value for everyone involved — employees, clients, vendors, and the broader community. After overcoming major personal challenges and rebuilding his perspective on leadership, Tom embraced stakeholder capitalism and built a company culture focused on long-term partnerships, trust, and continuous learning. In this conversation, Tom shares the IronTech Framework — a practical approach to modern IT management built around three core pillars: Generate ROI and Productivity, Make Cybersecurity Core, and Surround it with a Governance Layer. He explains why businesses should stop treating IT as an expense and instead view it as a strategic investment that improves productivity, protects the company from cyber threats, and aligns technology with leadership goals. Tom also dives into the massive scale of the cybercrime industry, why governance is often the missing piece in cybersecurity, and how proactive IT strategy can dramatically improve business performance. — Turn Your IT into Your Growth Engine with Tom Kirkham Good day. Steve Preda here with the Management Blueprint Podcast, and today’s guest is Tom Kirkham, the Founder and CEO of Kirkham IronTech, where he helps businesses build strong, secure IT foundations, whether fully managed, co-managed, or cybersecurity only. Tom is a keynote speaker on cybersecurity, and he’s the author of two books, Hack the Rich and The Cyber Pandemic. Tom, welcome to the show.  Oh, it’s great to be here, Steve.  Well, great to have you here. And I am curious to dive in, and would like to ask you my favorite question. What is your personal ‘Why’, and how are you manifesting it in Kirkham IronTech?  That’s a great question. So the company’s about twenty-six years old. I went through a lot of personal health problems, and then my wife was real sick, and she ended up passing away—it's been about eleven years ago now. And I was fortunate enough to put a friend of mine in the company, and he was able to take over while I was dealing with this for a couple of years. And when most of it was done, I took some time off and did a lot of traveling and a lot of thinking and a lot of reading. And I’m a lifelong reader, a lifelong learner, and I went back through my history of investing techniques, understanding what makes a good company great. If you’ve read Jim Collins, you know what I’m talking about. And so during those times, I was reflecting, studying philosophy, studying biographies of other CEOs like Elon Musk, Steve Jobs, Andy Grove—gosh, the list goes on and on. Whether you like them or hate them, it doesn’t matter, right? There’s always something you can learn. And I came upon and read a lot about stakeholder capitalism. Like Peter Drucker says, “Culture eats strategy for breakfast.” And I understood what that meant, and it was kind of weird. So when I re-engaged with the company, I identified one of the weaknesses, and I said, “Well, if we need to do marketing in this business—which we have to do in any business—I really need to master marketing.” So I spent a lot of time with marketing gurus, most of them are what I would consider household names these days, and re-engaged with the company to do marketing to establish a great culture around stakeholder capitalism. In other words, we exist as a for-profit business not just for the shareholders but for everyone—the community, vendors, employees. And I really wanted to be around people I enjoyed being around. I wanted them to enjoy coming into work.Share on X And so we’ve been trying to perfect that system in the culture for the past ten years. Of course, no one's perfect, but if you pursue perfection, you can achieve excellence. And I think we've done a really good job. We have very low turnover. Everyone seems genuinely happy to be there, and it's really fulfilling. It's more of a personal feeling because I've been a successful investor practically my whole adult life. I started investing in stocks when I was nineteen, and I'm sixty-four now. So I didn't really need the company. I could have just closed it up or sold it or whatever. But I really wanted to have my own reasons. Those are the things that drive me, and I hope they drive everyone else too.  What resonated with you with this idea of stakeholder capitalism? It just made sense. The obvious part is with employees—all of that is true. That's obvious to any good leader or manager, right? As you well know, there's a difference between leadership and management, and understanding that distinction, and the difference between sales and marketing, and understanding those things. A good example is dealing with vendors. There are all sorts of vendors that supply products and services to us, so we carefully vet these tools and vendors to see if their values align with ours, just like we do with prospects. But especially with vendors, if it's something new—a new tool that we're going to invest a lot of time, money, and energy into to make their product or service successful for us and successful for them—we make a commitment to that vendor.  So it's not about the money or how cheap I can get it. What I want is a good partnership with every stakeholder. And I want to make sure that when I'm dealing with a vendor, if it fails for us, it's not our fault—it's their fault, right? Either they oversold the product or they didn't deliver on the service component. I didn't want it to be because we failed to do the right training, or didn't communicate properly, or missed all the other things that are just part of doing business the right way. And that applies to our employees, our local community, and every stakeholder in the company.  Yeah. I like it. So you're looking for partnership-based relationships where it's win-win. And yeah, if you want people to stick around, it has to make sense for them too. You can't exploit your partners forever without consequences. So that makes a lot of sense. So Tom, let me ask you this other question. This podcast is called The Management Blueprint because I'm always looking for frameworks—something practical that helps businesses achieve results. Usually it's some kind of three-to-five-step process that helps you grow the business, get customers, improve operations, or understand something at a deeper level. So when I ask about your favorite business framework, what comes to mind?  Well, we have a thing we call the IronTech Framework.  Okay.  And it was something that we came up with many years ago and started practicing seven or eight years ago, and it's a framework. It's like the NIST Cybersecurity Framework. I looked at NIST and there's five components to it, and it's about cybersecurity. And I looked at this and I go, “None of this works without the right policies and procedures in place.” The security training—it's not enough just to throw it out there and tell all your people to take it. You've got to follow up, you've got to manage, and coach, and everything like that. And so I started adding this governance component to the way we sold it, presented it, and practiced what we do for our clients day in and day out. Help them develop the policies and procedures for all of the different things, the protocols.  If somebody accidentally fires off a ransomware attack, they need to know they're not going to be penalized for it. We need to know as soon as possible to stop it. And just little things like that, there's a lot that really improve the effectiveness of all of these tools and services that we provide to their clients. And unbeknownst to me, NIST, who has the cybersecurity framework, they added governance about three years ago to the other five things. And so that was kind of nice to know that we were exhibiting some thought leadership. And so when we go in, it's all well and good if you want to put these protections in and these particular products, but we're a best-of-breed company. Like one of our critical tools that's required for our clients to put in place, to buy it and use it every single day on every single computer, is what's known as an EDR. And it's basically an AI-based super turbo antivirus.  To even call it an antivirus is not doing it justice. So there's three legs to the IronTech Framework. We want to make sure that you're getting a return on your investment in IT, because that's why you buy it. If you treat IT as an expense, you need to kind of change the way you're thinking. You want to improve productivity and efficiency.Share on X The second leg is cybersecurity, because a bad cyberattack can put you out of business. I think the last stats I saw were something like 40 to 60% of businesses go out of business within two years of a significant cyberattack. And then finally, the third is governance. That's the three legs of our IronTech Framework. So part of governance is engaging with our clients' management and leadership—the CEO, finance, of course the CIO, the CISO or security officer, and maybe even the board sometimes. Really getting to know: what are your objectives, and how can we utilize our services to best help your company realize those objectives? Because for most companies, there's no other vendor they engage with as much as us.  We're talking to Susie every day. We're talking to Bill every day. We know that Mary's out sick and Steve's on vacation. I mean, when you're running help desk, stopping attacks, providing training, and all the support we provide along those lines, we get to know their company better than practically any other vendor by far. So it really helps if our clients treat us as a partner to help them realize their goals and objectives. And when all of that clicks into place, then it makes recommending things easier.Share on X “Okay, you need to replace these 30 laptops that are four years old. You're not getting an ROI on them.” “This server's five years old. Let's start thinking about replacing it.” “We have this new tool that's really excellent. We're recommending everybody get it.” And because we've developed that trust, those conversations become pretty easy. For the most part, everybody just says yes. But of course, we don't sell just to sell, especially when it comes to things like hardware. That's not really what we're here for. We're here for the day-in, day-out work: keeping things running, stopping breaches, and putting the policies and procedures in place to run your company as smoothly as possible.  Yeah. I love that. So when I had an IT back in the 2000s, I had an IT person who was a contractor, but he was very active in my business, and I always wanted to talk to him and pick his brain. What are the new things out there? How can we make our business more efficient, more effective, more attractive to employees? Cooler. I wanted to be cool. So I wanted everyone to have a PDA in the early 2000s with email on it—a PalmPilot. And we had multiple screens, and I was looking at, okay, how can we manage data in the cloud and on our server so we don't have to deal with it in the office? That kind of stuff. And I really thought about it as a great investment because it was much cheaper than hiring people. And if you give people good tools, they're going to be more motivated and more effective. So I thought it was a no-brainer.  Yes, but there's still a subset of people that treat IT as an expense. Then there are some companies that tend to put IT under the finance guy because the finance guy usually has a lot of IT experience, but never actually did it as a career or a job, right? And those situations are hard because I need CEO-level or owner-level approval, and I need a direct route to that person.  Yeah, that makes sense. So Tom, tell me, what drives growth in your business?  Yeah. From a growth perspective, for us, number one is maintaining our clients and reducing churn. Number two is—I don't know if you're asking about tactics or strategy—but of course we want to get new clients for the right reasons. So we prefer inbound strategies. We don't cold call people unless we've already contacted them in another way, if that's what you're asking.  Yeah. I'm asking what the real driver of growth is. I understand that you do marketing and inbound marketing, but what makes people want to have an IT service partner like you? Well, they understand those three pillars of the IronTech Framework. They may not believe in stakeholder capitalism, but they don't treat IT as an expense. And they understand—especially after talking to me—the true risk of being hacked. A lot of people don't understand the size and scale of that industry. It's a $10 to $12 trillion industry now.  Wow.  If it were a country, it would have the third-largest GDP. The US would be first, China second, and then the hacking industry. It is an industry that hacks at scale. So when these companies—maybe a small 10-person accounting firm in North Dakota in the middle of nowhere—get these ransomware emails and someone tries to hack them, and we alert on it and trap it, and nothing goes wrong, everything's fine… If they don't already understand it, they go, “Well, why are they trying to hack me?” And I say, “You don't understand. That email was one of 100,000 emails that got blasted out. They don't know who you are, nor do they care who you are.” They're playing a numbers game. And it's kind of like marketing. They're looking at conversion numbers. Yeah.  Let's say it's 100,000 emails. They got a list of all the certified public accountants in 10 different states. They set up the email, they send it all out, and let's say 1% become victims. And let's say they collect an average of $10,000 per victim. Well, that's a multi-million dollar payday for about a week or two of work. And then they rinse and repeat. It's done at scale, and it's a much bigger industry than that. That's just a taste of it. Some of our clients are targeted. In other words, hackers are investing time, money, and energy specifically into that company. We're one of them. Any law firm that does intellectual property law—especially around patents, manufacturing, and things like that—you've got China and other nation states not only trying to get into your client, but you're also a threat vector. You're a way to get into that client's patents and secrets.  So we've got to treat that differently. It's not just about the money. There are different types of threat actors, and we have to educate clients, bring them up to speed, and say, “Well, because of this case, you need this other service and tool that we're offering to prevent China from breaking in.” Or, “You need to follow this practice.” Maybe you don't publicly talk about one of your clients being Ford Motor Company or NVIDIA. You just keep that quiet. You don’t want that to be public knowledge. That's one of the things we do. You spent time on our website, and you didn't see a single client name on there. And that's just one of the small things we do to protect our clients' security and privacy, because privacy and security go hand in hand. Yeah. That is fascinating. So what is it that you’re trying to figure out in your business right now? What’s the big thing for you?  I think because of all the chaos in the United States, making a decision to do anything—everybody's kind of frozen. There are a lot of hiring freezes. I know we've got a freeze on right now because we're looking to see, well, do we really need to add somebody, or can we do this with AI? The hackers do the same thing. That's one of the challenges, is getting people over the hump. No matter what you do, if you've got an IT company doing your stuff and you only call them when things are broken, there's a much more profitable way to do that. You're spending more money.  So there are benchmarks in industries, right? Basically, the research—and these aren't numbers we made up, this is legitimate research from many independent sources—says the average professional service provider, like law firms, accounting firms, healthcare providers, and on and on, should be spending 6 to 12% of their revenue on IT and cybersecurity. And that's everything. I'm talking servers, wiring, cloud, security, defense—all of those things should be 6 to 12%. We know that. That's the way it works. So when we engage with a prospect and find out they're only spending 3 or 4%, then I already know they have gaps. I don't even have to do an assessment to see what they're not doing.  They're either not getting a return on investment, or they're not secure. That's it. If all the accounting firms are spending 6%, and you're only spending 4%, don't just pat yourself on the back. That's one of those moments where you should ask, “What am I missing?” Because I do that often. Someone on the management team will come up with an idea, and we all agree. Well, that's a red flag for me. I want to know: what are we missing? If we all agree on this, is there some gotcha or something we haven't uncovered? And those are some of the things we try to educate our clients on. They don't have to tell us their revenue. I can give them the numbers. I can do the math. I can show them the numbers for something like laptop replacement. Maybe it's $1,000 to $3,000 depending on the industry. If the employee using that laptop is making $100,000 a year, why are you trying to squeeze another year out of a $2,000 investment when it's hurting productivity by 10% or more? Yeah. That’s a no-brainer.  Yeah. It should be.  Yeah. It's not just in IT. I had a client years ago in civil engineering, and they had a rule that they would never keep equipment longer than four years. And they were selling equipment that still looked brand new. And I asked them, “Why are you doing this? It seems like this equipment still has a lot of life left in it. Why are you selling it or giving it back to the lease company?” And he said, “We did the math, and we figured out that this is the optimal time to replace it.” If they got rid of the equipment at that point, they wouldn't have to deal with fixing it. There would be less disruption. They would stay state-of-the-art all the time. And their clients would be impressed. And it actually worked for them. It was a high-margin civil engineering firm.  Precisely. I mean, we're so tuned into that that we're a Mac house. We all use Macs. We all have laptops, and we all have setups with screens at home and in the office. We spare no expense on that. If somebody wants an extra screen for their house—alright, here it is. We'll order it and get it there for you. We're so tuned into that, that we went all Mac back when they were still Intel Macs. And I don't know how much you know about Macs, but they were…  I have a couple. Okay. Yeah, we're Mac people too. Yeah, so they were running Intel processors. Well, Apple decided to build their own processor and moved to the M-chip. And so I bought an M1, and it was like, holy cow, everybody in the company has got to have one of these. And I don't think there was a single one more than two years old at that time. So we replaced them all. Now, the M-series generations themselves—M1, M2, M3, and on—those changes aren't as dramatic as going from Intel to the first M-series chip. But it's still unusual. I said two years, but there are probably people right now with a three-year-old laptop. But we definitely trade them in. That's where the sweet spot is on trade-in value. We rotate them every two to three years and they're out. I think mine is maybe a year old, but I'll probably keep this one for a couple more years.  By the way, you're the first IT company and MSP I've met that doesn't use PCs—you use Macs. Yeah. And I long had this theory that all the IT companies I worked with were always anti-Mac, and I never understood why. And when I got my first Mac, I realized I actually didn't need them anymore since I had the Mac.  Yeah, that's kind of funny because it really started with me during Covid. It may not have been seven years now, but whatever it was, it kind of started with Covid. And for years I was a PC guy. I tried Macs briefly back in the old MacBook days—you know, the white plastic ones? Whatever that was, 15 or more years ago.  Yeah. Classic. Very classic.  Yeah. But what I kept trying to do with a Windows laptop—and I like Dell, I had Dell XPSs, good Dell computers, and we're a Dell partner— What I could never get a Windows computer to do was seamlessly come off a docking station and then plug into another monitor at my house. It would always blue screen or something. So when I went back to a Mac, I was like, “Holy cow, it doesn't break. It doesn't mind being unplugged from a docking station. It just works.” Yeah.  And then all the other things—that they're generally built better, they have a longer lifespan, and they hold their resale value longer, and all of that. Even as old as I was, I forced myself to really get proficient at using a Mac. And when we sent everybody home during Covid, I said, “Well, everybody's going Mac.” And, oh, there was a revolt. And I said, “Just give it a few months.”  Yeah.  About half the office resisted it. And I said, “You gotta try it because I think you'll like it, and if you don't, then we'll deal with it then.” We had Linux people, PC people. So then I said, “Well, maybe we should open it up and let people pick what they want.” Yeah, I love it. Yeah. So our time is coming to an end, but if someone is running on Mac and they're finally talking to an IT service company that's not anti-Mac, and they want to connect with you immediately, where should they go and where can they learn more about Kirkham IronTech and maybe connect with you personally? The website is the best place to go. It's www.kirkhamirontech.com. Just give us a call, fill out a form, let us know what you're thinking, because we want to know what you're thinking and see if there's a fit with the way we do things. Macs started becoming important with executives. That's where we first started seeing it. So even though they may still have to run Windows, the owners and executives wanted to carry Macs for the very reasons I mentioned. So we're perfectly happy with that.  Yeah. Okay. Very good. So if you're listening to this and you enjoyed hearing about how to make your IT work—how to increase ROI, make sure you're doing cybersecurity right, and implement governance so you can use IT as a strategic tool to run your business better—then definitely reach out to Tom Kirkham. Or stay tuned to this show, because you're going to hear from other entrepreneurs who are very smart about business. And preferably do both. Tom, thank you for coming and sharing your wisdom, and thank you for listening.  Oh, it’s been my pleasure, Steve. Important Links: Tom's LinkedIn Tom's website

I sat down with Marco from MoveItOn at ConsenSys Miami to talk about something I hadn't seen before — a peer-to-peer delivery platform that turns everyday travelers into courier agents. Think Uber, but for shipping. Marco walks me through how they use smart contract escrow to build trust between strangers sending valuable items, how their M1 token powers cross-border payments, and why they just acquired a Web2 company called GlocalZone with 1.5 million app downloads to hit the ground running. We also get into the regulatory maze of operating across 100+ countries, the AI-powered security boxes they plan to place at airports and train stations, and why the last-mile delivery problem is one that AI agents simply cannot solve on their own. If you're interested in how blockchain and real-world logistics can come together to save people money and create new income streams while traveling, this one is for you. Disclaimer:Nothing mentioned in this podcast is investment advice and please do your own research. It would mean a lot if you can leave a review of this podcast on Apple Podcasts or Spotify and share this podcast with a friend. Be a guest on the podcast or contact us - https://www.web3pod.xyz/Connect:MoveItOn Website: https://www.moviton.com/ Key points with Timestamps • [00:00] Sam introduces Marco from MoveItOn, recorded live at ConsenSys Miami• [02:00] Marco's background — how writing a blockchain book for beginners pulled him into the industry• [04:00] He has three published books: Blockchain Millionaire, a crypto beginner lexicon, and a tokenization guide• [05:30] What MoveItOn is — a peer-to-peer delivery platform turning travelers into courier agents• [07:00] The founding story — a co-founder from Kazakhstan couldn't ship medical items via DHL but could carry them personally• [09:00] How blockchain fits in — smart contract escrow requires couriers to deposit the value of items they carry• [11:00] The M1 token powers payments and couriers earn staking rewards while funds are locked• [13:00] The GlocalZone acquisition — a Web2 peer-to-peer delivery app with 1.5 million downloads and 70,000 active users• [15:00] MoveItOn has been in development for about 18 months, Marco joined 8-9 months ago• [17:00] Biggest challenge is regulation — launching in 10 compliant countries first, using AI to track changing import laws• [20:00] Go-to-market strategy — partnerships with flight booking and car-sharing platforms, solving the last-mile problem with logistics companies• [23:00] B2B infrastructure and future plans for AI agent integration• [25:00] Blockchain and AI adoption across banking, medicine, and other industries• [27:00] Solving the marketplace chicken-and-egg problem through partnerships and acquisitions• [29:00] Current fundraising — private and pre-sale done, public sale in 4-6 months, seeking $4M in VC or angel funding• [31:00] Move It Boxes — AI-powered smart lockers at airports and transport hubs for contactless drop-off and pickup• [35:00] Vision for 2030 — 100+ countries, doubling the current 1.5 million user base• [37:00] Open to partnerships, investors, and remote team members — headquartered in Dubai

ぬるぽ放送局おたより投稿フォーム https://forms.gle/6tbmBzK6wbyavJG47 2026年5月パワープレイ M1. One Era feat. DD"ナカタ"Metal Produced by RoughSketch Vocal by DD"ナカタ"Metal 収録アルバム：NBCD-052 20 Years Of RoughSketch: Golden Best & Remixes 2026 2026・4・26 Release https://notebookrecords.net/discographyportal.php?cdno=NBCD-052 番組時間：88分33秒 出演者：夕野ヨシミ、たくや VOICEVOX:ずんだもん VOICEVOX:四国めたん ---- 2026/5/21に公開録音したものを配信いたします。 ラジオ記事はリスナーのEEチャンピオンさんが書いてくれているので楽してます。 ＜オープニング＞ ・煩悩10倍ですよ ・今回くらいはバニーの話やめますか？ ・バニーの話がないと無言ですよ ・変わらずやってます ・イオシスくんの近況報告 ・東京イベント物販ですぐ完売しちゃったラフスケッチぬいぐるみ ・売り切れる前に買ってください ・まとめ買いのチャーンス！ ・値段設定間違えちゃった？ ・楽曲提供しました！ 　『東方LostWord』「ラストワールド　～ LastWorld」 　原曲：亡き王女の為のセプテット 　編曲：ARM (IOSYS) 　作詞・ボーカル：ビートまりお 　ギター：西山昌一郎 ・コナミさんのお知らせ 　『jubeat beyond the Ave.』で2026/5/21から遊べます！ 　「スカーレット警察のゲットーパトロール24時／七条レタスグルー　プ」 ・どこにでもいるスカ警 ・ラフさんはカナダへ ・新千歳からサンフランシスコに直行便 ・時差ボケしたことあります？ ・気合では無理 ・自律神経は無に帰しました ・名古屋で味仙に行きたい ・にんにくに自律神経を支配される ・いつもまじめじゃないんですね ・イオシス事務所無くならなくてよかったね ・昼間なら警察来てますよ ・両隣がまじめな会社でよかったね ＜Aパート＞ ・ドライTシャツを着るシーズンになりました ・たくさん買ってください ・ふつおたです ・山形は寒いって ・東京はもう、40℃あります ・ブース設営で8割疲れちゃう ・最近は夏コミに行ってないので ・改修工事で空調3000倍 ・スーパー田植えタイム終了 ・設営で8割は合ってる ・2日やって、翌日30分 ・農家「いいよー」 ・15万のホイール ・今、乳首って言いました？ ・お米を作るゲームじゃないんだ ・Forza Horizon 6がおすすめ ・ゲームだから飲酒運転はどうですか？ ・バニーガールの話題出ちゃったなー ・名探偵マーニーとフランケンふらん ・巡回済みだったか ・AIぬるぽ放送局 ・これもう、はかせいらなくね？ ・しれっとAIはかせ ・やればできそう ・ずんだもんにした方が可愛くていいね ・漫才やりますか ・ちょっとだけ自己紹介を変えておきました ・だれが加護ちゃん世代だよ ・勝新世代って ・ヤニ漫画がアニメ化されてく ＜Bパート＞ ・みつをたです ・北海道の匿名の方から ・JAの仕組みとは ・わかんないまま批判するのはよくない ・バニーちゃんと遊んでるのは部分的にそう ・札幌市は人口減ってますよ ・デカ岡市 ・今、バニーガールのこと考えてたから ・そろそろ返してほしいですね ・温かくてシャケが獲れない ・ずっとバニーの話してる ・ファンティアが大変 ・強めのモザイクかけときますね〜 ・にじフェスピックアップニュース ・ケツよさん ・イチボをケツ肉とは呼ばない ・３Dちょまのカラオケが可愛かった ・ホロピックアップニュース ・大空スバルさん200万人突破おめでとうございます ・広島の花ソーセージ ・ニュースが多い ・Vピックアップニュース ・今週も新しい固有名詞を浴びました ・おっぱいを大きくしたい ・あっ、おめでとうございます ・各種お便りお待ちしてます ・ふつおたに短いメッセージを送ってみてください ・Do you like Wednesday? ＜エンディング＞ ・デカ箱イベントは大変だよー ・今年は晴れるといいなー ・なくなった裕次郎記念館 ・昭和ってやべーな ・あの頃はモザイクがかかってたね ・真田丸面白いです ・平成怖いよー ・マシュマロってやったことないな

Tagokat cserél a Fidesz-frakció a parlamenti bizottságokban Orbán Viktor eltűnt az M1 híradójából Két elnököt is kiosztott Magyar Péter Újra beleállt Balog Zoltánba a tiszántúli református püspök Idea-felmérés: A magyarok többsége lezártnak tekinti Orbán Viktor politikai karrierjét Euróbevezetés: óriási a piaci bizalom, de hosszú utat kell még megtenni – Interjú Az Országgyűlés lecserélése az Európai Parlamentre Orbán Viktor is megszólalt a tiszaújvárosi robbanás ügyében Az Orbán-kormány elköltötte az egész évre tervezett hiány több mint 90 százalékát Wáberer György veszített Robbie Keane távozhat a Fradi éléről, sajtóhírek szerint már fel is mondott Elege lett: Hamilton megszólalt az F1-es jövőjéről A szezon első hőhullámára készülhet Európa A további adásainkat keresd a podcast.hirstart.hu oldalunkon. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Tagokat cserél a Fidesz-frakció a parlamenti bizottságokban Orbán Viktor eltűnt az M1 híradójából Két elnököt is kiosztott Magyar Péter Újra beleállt Balog Zoltánba a tiszántúli református püspök Idea-felmérés: A magyarok többsége lezártnak tekinti Orbán Viktor politikai karrierjét Euróbevezetés: óriási a piaci bizalom, de hosszú utat kell még megtenni – Interjú Az Országgyűlés lecserélése az Európai Parlamentre Orbán Viktor is megszólalt a tiszaújvárosi robbanás ügyében Az Orbán-kormány elköltötte az egész évre tervezett hiány több mint 90 százalékát Wáberer György veszített Robbie Keane távozhat a Fradi éléről, sajtóhírek szerint már fel is mondott Elege lett: Hamilton megszólalt az F1-es jövőjéről A szezon első hőhullámára készülhet Európa A további adásainkat keresd a podcast.hirstart.hu oldalunkon. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Apple has not always been known as the bargain option, but the latest Apple Silicon Macs might be changing that conversation. In this episode, the team gets into the surprising value of the M4 Mac Mini, why even a base model can be serious overkill for many voice actors, and how smaller machines like the MacBook Air and MacBook "Neo" style systems compare for remote sessions, Source Connect, Pro Tools, and travel rigs. The conversation also wanders into classic Pro Audio Suite territory, including old Macs that refuse to die, running Linux or Windows on ageing Apple hardware, right to repair, weird manufacturer lockouts, obsolete cables, Shure MV88 bargain hunting, Pro Tools archiving disasters, and why keeping your sessions self contained still matters. There is also a very important chainsaw story. Obviously. Thanks to our sponsors, Austrian Audio, making passion heard for supporting the show. 00:00 Intro and sponsor mention 00:33 Talking Macs before the show 01:20 The M4 Mac Mini and Apple's surprising value 02:29 Apple Silicon price to performance 03:38 Why older M1 machines still hold up 04:02 Using a Mac Mini as a road computer 05:22 Is the Mac Mini overkill for VO work? 06:38 MacBook Air, external monitors, and display quirks 09:04 Apple cables, chips, and control 10:04 The end of Lightning and the move to USB C 12:09 Audio interfaces on iPhone and iPad 12:30 Shure MV88 bargains for older iPhones 14:43 Right to repair 16:11 Robbo's old chainsaw story 18:21 Repair restrictions and replacement culture 19:29 Mac longevity 20:18 Running Windows on an old iMac 22:03 Linux on old Apple hardware 25:29 Old drives, CDs, DVDs, and lost archives 26:12 Mezzo and old Pro Tools backups 27:13 Missing Pro Tools audio files 28:33 Pro Tools archiving tip, sort by file path 29:54 Wrap up and credits

Damos un repaso rápido a Apple TV antes de meternos en harina. Ángel entrevistó a Kyle Andeer, vicepresidente de Apple, y explica cómo las exigencias de Bruselas para abrir el sistema operativo a terceros chocan frontalmente con las políticas de privacidad y seguridad de la compañía. Además, debatimos sobre el conflicto emergente con OpenAI, cuyos directivos estarían considerando tomar medidas legales o expresar su frustración debido a que los retrasos en la nueva versión de Siri han diluido la exclusividad y el beneficio esperado de su acuerdo inicial con Apple.Nos quedamos ojipláticos ante el nuevo Googlebook, y encajamos la verdad sobre el Macbook Neo de Álex.Por otro lado, exploramos los rumores más llamativos de cara a la próxima WWDC, destacando las novedades que podríamos ver en el ecosistema móvil, como la llegada de los "Genmojis" generados por IA, una interfaz de cámara mucho más profesional y personalizable, y un esperado botón en pantalla para deshacer acciones.erminamos comentando el sorprendente éxito en los premios de diseño de Liquid Glass, y analizamos el reciente hackeo a una fábrica de Foxconn en Estados Unidos, fantaseando con humor sobre lo que implicaría una filtración masiva de los secretos industriales y proyectos cancelados de Cupertino. Anthropic's Mythos Found Bugs in Apple's MacOS - WSJ Apple's F1 Streaming Ambitions Hit Wall as Sky Renews European Rights - MacRumors How Apple TV's Upcoming Fantasy Show Could Run for 10+ Seasons (& Might Not End Until the 2040s) - ComicBook.com MacBook Neo Processor Benchmarks: A18 Pro CPU vs M1 and M4 Apple criticises EU measures to help AI rivals access Google services Reuters Apple Project Files Allegedly Stolen in Foxconn Ransomware Attack - MacRumors EU iPhone Users Get AirPods-Like Pairing and Notification Forwarding for Third-Party Wearables in iOS 26.5 - MacRumors Googlebook: Designed for Gemini Intelligence Coming Fall 2026 - Googlebook Meet - awm-zzhz-fda Foxconn confirms cyberattack after Nitrogen claims Apple, Nvidia data theft Apple criticises EU measures to help AI rivals access Google services Reuters Apple frente a la Ley de Mercados Digitales: "Nos están obligando a dejar funciones fuera de Europa" Creadores EU iPhone Users Get AirPods-Like Pairing and Notification Forwarding for Third-Party Wearables in iOS 26.5 - MacRumors Dazn se hace con los derechos de la Fórmula 1 en España hasta 2026 Palco23 Anexo:Derechos audiovisuales de Fórmula 1 - Wikipedia, la enciclopedia libre TV Shows on Apple TV (May 2026) Rotten Tomatoes How Apple TV's Upcoming Fantasy Show Could Run for 10+ Seasons (& Might Not End Until the 2040s) - ComicBook.com Satisfacción garantizada - Apple TV Press (ES) OpenAI preparing ‘legal action' against Apple over Siri partnership: report - 9to5Mac La cámara del iPhone sería totalmente personalizable en la próxima actualización de Apple - Infobae What award did Liquid Glass win? Apple Project Files Allegedly Stolen in Foxconn Ransomware Attack - MacRumors

Could the bond market smack down the exuberant US stock market? Hosted by Michelle Martin, this episode of Market View explores whether surging US bond yields could become the biggest threat yet to richly valued equity markets ahead of a crucial earnings week featuring Nvidia, Walmart and Home Depot. Michelle unpacks what the bond market may be signalling about inflation, borrowing costs and investor confidence, while examining the widening AI ecosystem beyond Nvidia through companies like Cisco, Vertiv and Arista Networks. She also looks at what discount retailers TJX and Ross Stores may reveal about the health of the US consumer and the rise of the “trade-down economy” as shoppers hunt for value in an uncertain environment. Closer to home, Michelle breaks down the uncertainty surrounding Singapore’s telecom sector after IMDA suspended its review of Simba Telecom’s proposed S$1.43 billion acquisition of M1 amid a regulatory probe. The episode ends with a look at rising oil prices linked to tensions around Iran and the Strait of Hormuz, as well as renewed investor interest in space infrastructure plays like Rocket Lab and AST SpaceMobile.See omnystudio.com/listener for privacy information.

Singapore’s telecom landscape has taken a sharp and unexpected turn, as Simba’s proposed $1.43 billion acquisition of M1 moves close to collapse. The development follows IMDA’s decision to suspend its review amid allegations that Simba may have used unauthorized radio frequency bands, leading Keppel to confirm it will let the deal expire by May 21. With the transaction now effectively off the table, M1 returns to the market, opening the door to potential new buyers. Who might ultimately step in as the next owner of one of the country’s key mobile operators? And, what does this mean for competition, prices and trust in the sector? On The Big Story, Hongbin Jeong speaks with Manoj Menon, Founder, Twimbit, to find out more. See omnystudio.com/listener for privacy information.

出演者： miko、quim 配信ペース： 隔週 番組時間：100分55秒 ♯本番組はリモート収録です。 ♯収録時環境の影響により、全体的に聴き取り辛くなっております。 　申し訳ございません。 隔週に1回お届け。mikoラジ、第397回です。 GW、終わっちゃいましたね……次の祝日は7月です。 病み上がりのしがないさん、労働は害悪な我さんのそれぞれのGWとか、GW明けとか。 ふたつの初めての○○○○があったり、いつも通りと特別と。 最後までごゆるりとお楽しみくださいませ。 ♯途中で色々とノイズ等入りますが、収録時のものです。 　ご安心ください、お手持ちの機器は正常です。 ・おとらってRECORD 公式サイト n-remix.com/otolatte/ ↑『おとらって10thライブ KUWANA』に参加予定の方は、 　「来場予約はこちらから」からご予約を！ 開催日／2026.8.23(日) 　第一部　OP11:30　ST12:00 　第二部　OP14:40　ST15:00 //////////////////// VOICEVOX:ずんだもん VOICEVOX:四国めたん //////////////////// -------------------- ●お便り募集中！ mikoラジでは以下の内容でお便りを募集中です！ ・ふつおた 　／普通のお便り、お待ちしています！ ・mikoは大変な絵を描いていきました 　／miko画伯に描いて欲しいお題をお待ちしています！ ・メシヲコエテ 　／料理人・mikoに教えて欲しいレシピをお待ちしています！ bit.ly/2GAWjyv 投稿フォームからラジオに投稿が出来ます！ コーナー名を選び、メッセージ・ラジオネーム・お所を入力して、 どんどん送ってください！　お待ちしています！！ ------------ 本ラジオのメインパーソナリティーである「チーム我等(miko/quim)」、 それぞれ以下個人サークルにて活動中です。 ・miko：miko ・quim：SHIGANAI RECORDS（ shiganai.com/ ） 活動詳細については、上記HPの他 各人のブログ/twitter等にて随時告知しておりますので、チェックしてみてください！ ・みころぐ。(mikoのブログ)（ ameblo.jp/miko-nyu/ ） ・@ mikonyu(mikoのtwitter)（ twitter.com/mikonyu ） ・@ quim(quimのtwitter)（ twitter.com/quim ） --- その他の活動については、以下のとおりです！ -- チーム我等がメインクルーとして活動していた「アルバトロシクス（ albatrosicks.com/ ）」、 これまでリリースしたCDは、イオシスショップ（ iosys.booth.pm/ ）にて頒布しております。ご興味ある方は是非！ ---------- ☆2026年5月IOSYSはいてない.comパワープレイ楽曲 M1. One Era feat. DD"ナカタ"Metal Produced by RoughSketch Vocal by DD"ナカタ"Metal 音楽ジャンル：Hardcore 収録アルバム：NBCD-052 20 Years Of RoughSketch: Golden Best & Remixes 2026 2026・4・26 Release https://notebookrecords.net/discographyportal.php?cdno=NBCD-052 積み重ねた『ジャパニーズ・ハードコア』を貴方に クリエイター「RoughSketch」の活動20周年を記念した2枚組アルバム。 書き下ろし新曲を含めたベストアルバムに加え、ディスク2には活動の中で出会った日本全国各地のトラックメイカーによるRemixが集結！ CD特典コンテンツとして2026年3月8日に行われた6時間ライブセットの音源をフルでダウンロード可能！

W/C 11th May 2026A thought struck me as I was walking through Charles de Gaulle airport last week. I wondered how far I was standing (at that precise moment, in that exact spot) from somebody that I knew, but was unaware of.And not just that moment, maybe the last time I was in London or in Leeds, or on holiday or on the train, etc, etc.Clearly with the tech we have at our disposal we can (to an extent) answer that question with stuff such as location sharing, and snap-maps. But that only works with an engaged friendship group, and not necessarily everybody we have ever come into some form of contact with.So the question remains, how close do we pass to people we are acquainted with, but never actually bump into. Was an old school friend also passing through CDG at the same time as me last week, or taking coffee in Headingley yesterday whilst I was at the cricket, or being stuck in the same queue as me on the M1 on Tuesday evening.Answers on a postcard please.Stay safe.Honesty - Billy JoelTherapy For Me (or TFM as I now refer to it) is a bit of an audio curiosity. It started out as a mechanism for me to clear my head, with the hope that by saying stuff out loud it would act as a little bit of self-help. It's remains loose in style, fluid in terms of content and raw - it's a one take, press record and see what happens, affair.If you want to keep in touch with TFM and the other stuff I do then please follow me on Facebook, Insta, Twitter or Patreon. Thanks for getting this far.

ぬるぽ放送局おたより投稿フォーム https://forms.gle/6tbmBzK6wbyavJG47 2026年5月パワープレイ M1. One Era feat. DD"ナカタ"Metal Produced by RoughSketch Vocal by DD"ナカタ"Metal 収録アルバム：NBCD-052 20 Years Of RoughSketch: Golden Best & Remixes 2026 2026・4・26 Release https://notebookrecords.net/discographyportal.php?cdno=NBCD-052 番組時間：79分35秒 出演者：夕野ヨシミ、たくや VOICEVOX:ずんだもん VOICEVOX:四国めたん ---- 2026/5/14に公開録音したものを配信いたします。 ラジオ記事はリスナーのEEチャンピオンさんが書いてくれているので楽してます。 ＜オープニング＞ ・ガンプラを積んでる人とゲームを積んでる人と本を積んでる人 ・脳みそが３ついる ・もう、1週間経ちました？ ・気象予報士の資格を取りましょう ・バカの天気予報 ・夕野ヨシミ宅の天気予報 ・すすきのの夜の天気予報 ・高校の部活は何に入ってましたか？ ・30年前にPCってあったんですか？ ・イオシスくんの活動報告 ・母の日に700万再生ウイマーマサーガ ・楽曲提供しました！ 　「ガチマジ☆デスゲーム／一条莉々華(hololive DEV_IS ReGLOSS)」 　作詞・作編曲：uno(IOSYS) 　Guitar：NUE ・​​Nothing But Requiem は略するとNBRになっちゃう ・わざとなんですけど弊害が生まれた ・有馬わい​「ロバパンだ！」 ・たまに食べるパンはなんだ？ ・紐パン？ ・新装版3種を2026/5/31の東方名華祭で新規リリースします！ ・カラー印刷でよかった ・次の即売会参加のお知らせ 　2026/5/31 東方名華祭 　■IOSYS L-11/12 ・お品書きがイラストレーターファイルになりました ・Ctrl+7以上の思い出はないんですか？ ・YouTube IOSYS musicチャンネルにて 　IO-0336 TOHO BOOTLGES 6 　全トラックフルバージョン公開しました。たくさん聴いてね！ ・今月はラフさん無双だね ・やはり7人いるな ・ぴちぴちのジャージはBOOTHで買いました ・おすすめのラフスケッチぬいぐるみ ・イッパイカッテクレナイトイオシスツブレチャイマス ・カナダ現地時間0時は日本時間何時なのかな？ ・アメリカで東方のイベント ・2026/10/24 トークライブやります（阿佐ヶ谷） ・アリキラに夕野さんがゲスト出演します ＜Aパート＞ ・有馬わいさんは5文字しか打てないのかな？ ・ふつおたです ・リアルバニーもかわいいよね ・北海道は冬日&夏日 ・田植え２デイズ ・長靴を履かない農家になりたい ・農家は朝が早い ・播種とは ・直播のフローチャート ・三ちゃん農業 ・ばあちゃんは出稼ぎですすきのでバニーを ・イオシス農園早くやらないと ・アマプラ無料枠のおすすめのアニメ映画 ・アンジェラちゃん 検索しといてください ・令和の水野晴郎めざしましょう ・ハイボールならロックだね ・いやあ、映画って本当にいい感じですね ・焼肉とバニーガール ・行くなら最後のチャンス ・サラダバーいいですよね ・牛柄ビキニの焼肉屋さん ・☆５はやり過ぎなのでは？ ・初老の飲み会の報告 ・偏見のテクノ曲 ・GWに仕事が入らなかったはかせ ・あだ名が鬼だったので芸名はオニー ・人間シャンパンタワーやってましたね ・資本主義感じるねー ＜Bパート＞ ・尿管結石が割れそうな重低音 ・みつをたです ・暮らしのライフハック 　TwitterのGIF検索でU149って入力すると幸せになれます ・すみぺさんはTwitterがうまい ・人間みなロリかショタだったからね ・創作おとぎ話　赤穂忠臣蔵　最終回十三夜　エピソード ・かけないんですけどね ・大作お疲れさまでした ・ファンアート欲しいな ・あいだみつをさんをご存じない？ ・最後に確認するのは人間なんだよ ・にじさんじピックアップニュース ・ジョー力一さん濃い味なのでご覧ください ・角煮教 ・にじさんじフェス気になりますね ・アサミ閣下ドストライク ・ホロピックアップニュース ・さくらみこでもわかる参考書 ・Vピックアップニュース ・新しい固有名詞がいっぱいある ・直播を直播 ・ちふたんさんもグループなのでは？ ・通信料はお客様負担ですが無料でお便りが送れます ＜エンディング＞ ・一瞬だけ聞こえるはかせの声 ・大人になると誰も怒ってくれない ・五月病の具合はどうですか？ ・錬金病です ・我々は五月病になる機会がない ・見たことのないI ・コラボのカラムを比較的上に

Help Stop The Genocide In American Ghettos Podcast is a platform for ordinary law abiding citizens from Emmanuel Barbee friends list and from his social groups who are Black Artists, African Artists, Allied Healthcare professionals, Church Leaders, and Black Entrepreneurs, African Entrepreneurs who want to promote their products and services to our listeners from the global community. This no holds-barred talk show focuses on promoting Grassroots Community Advocacy, Business, Finance, Health, Community-Based Solutions, Employment, Social Issues, Political Issues, Black Issues, African Issues and Christianity which speaks to the interests of our listeners. Broadcasting on multiple social networks throughout the United States and around the globe. This show will provide insight on how our creative abilities can be used to create economic tangibles in our communities, neighborhoods and in Black countries. The Grass Roots Community Activist Movement is about uniting the low income Black Community with the African Immigrant Community starting in Chicago and eventually throughout the Diaspora. Emmanuel is not just online to sell his Revised Book and items from his Virtual Store or just trying to get donations for his Film Project but rather his aim is to recruit like minded Black Americans, like minded African Immigrants from 10 African nations within in the United States of America to assist him in building the best Black Christian Business within the United States called the Grass Roots Community Activist Institute of Chicago. Our objective is for us to build our own network, our own Community Grocery Store, Community Healthcare Clinic and Community Housing. #NotAnother34Years, #M1, #DAS-FM, #JoinGRCAM

(00:00) — Welcome and setup: from premed dropout to med student(00:47) — Corporate grind sparks the spreadsheets vs patients question(01:30) — Rewinding to undergrad premed and the 495 MCAT during COVID(03:15) — Finances and first-gen pressure push him off the path(04:35) — Articles, AI, and volunteering rekindle interest in medicine(06:10) — Leadership draw: why physician responsibility appealed to him(07:10) — Timeline: research job, 2018 grad, 2020 MCAT, business analytics at Fordham(09:05) — Undergrad habits, no planner, and managing ADHD with better tools(11:05) — Corporate wins build confidence (Big Four, Wall Street, AVP)(12:50) — Planning the leap: savings, living at home, loans, and side investments(14:10) — Bridge/SMP at Toro Harlem: structure and guaranteed-seat criteria(16:25) — Working at Citibank while starting the master's; then going all in(17:55) — Confirming fit: brief shadowing, almost passing out, but more intrigued(18:55) — Harlem community events as a student doctor and seeing disparities(19:52) — MCAT retake to 501–502; Kaplan and official full-lengths(21:27) — SMP mirrored M1 exams; Z-score cutoff and comprehensive exam(22:45) — M1 transition is easier after the SMP run-through(23:35) — Logistics: 3.45 GPA + comp exam = seat; could apply elsewhere(24:25) — Starting a tea franchise in Astoria with partners during M1(25:35) — Brick-and-mortar stress, construction, and opening mid-semester(26:50) — Hardest part: letting go of a six-figure salary(28:05) — Would he change his path? Choosing experience over speed(29:20) — Exploring passions helps future practice and options(30:52) — Keeping doors open: medicine, consulting, and business(31:28) — Parents' reaction: skepticism to tears of pride(32:34) — Final advice: build confidence and believe in yourselfZarak shares how he walked away from premed after a 495 MCAT and an average undergrad GPA, chased a thriving corporate career, and then found his way back to medicine. A first-gen student, he talks openly about family expectations, finances, and why spreadsheets and commutes couldn't replace patient impact. He explains the planning that made his return possible: saving while living at home, using loans wisely, and enrolling in a one-year bridge/SMP at Toro Harlem that mirrored M1 exams and offered a guaranteed seat with a 3.45 GPA plus a comprehensive exam. He retook the MCAT to around 501–502 using Kaplan and official full-lengths, and found confidence through improved study systems and corporate-built habits. Now an M1, he's volunteering in Harlem, reflecting on health disparities, and even launching a brick-and-mortar tea franchise in Astoria with partners—while keeping med school first. Dr. Gray and Zarak dig into letting go of a six-figure salary, rebuilding confidence, managing ADHD with better tools, and why exploring interests outside of medicine can strengthen your future as a physician.What You'll Learn:- How a low MCAT and average GPA didn't end his med school goals- What a guaranteed-seat bridge/SMP at Toro Harlem required- How he planned the leap: savings, loans, and timing while working- MCAT retake resources he used the second time around- Balancing M1 demands with launching a brick-and-mortar business

Dave and his M1 co-hosts Lily Schmidt, Melia Patrick, Jonah Albrecht, and Anna Royer, take a field trip to Reddit's AITA sub— because self-reflection is not usually how people figure out if they're the problem. Four posts, four verdicts, and get genuinely sidetracked in the best way: there's a chlamydia anecdote Dave shares, a philosophical debate about whether watching movies at 2.5x speed makes you a bad partner, and a surprisingly earnest conversation about what med students actually owe their families when they become the designated "medical person" in the room. And (med school parents, take note) a doctor-mom posts about telling her struggling pre-med daughter she isn't cut out for medicine--and Reddit tears her a ne...helps her understand why that's not the best approach.

ぬるぽ放送局おたより投稿フォーム https://forms.gle/6tbmBzK6wbyavJG47 2026年5月パワープレイ M1. One Era feat. DD"ナカタ"Metal Produced by RoughSketch Vocal by DD"ナカタ"Metal 収録アルバム：NBCD-052 20 Years Of RoughSketch: Golden Best & Remixes 2026 2026・4・26 Release https://notebookrecords.net/discographyportal.php?cdno=NBCD-052 番組時間：88分52秒 出演者：夕野ヨシミ、たくや VOICEVOX:ずんだもん VOICEVOX:四国めたん ---- 2026/5/7に公開録音したものを配信いたします。 ラジオ記事はリスナーのEEチャンピオンさんが書いてくれているので楽してます。 ＜オープニング＞ ・1000回もやってるこっちはいかれてるな ・サバを読むをテキトーに解説 ・昔はMDに吹き込んでいたのかな？ ・ミキサーから何に繋いでたんだ？ ・MDの回転音 ・最近のコンピューター部はすごいな ・イオシスくんの活動報告 ・GWなのでイベントがたくさんありました ・ちゃんと服を着てた夕野さん ・スタバのくしゃくしゃの紙を持ってた ・D.wattは、ちゃんと財布を持ってきてました ・元気だったイノキーさん ・エモかった例大祭 ・20年ずっと出てるなー ・焼きそばとタコ焼きはありませんでした ・結局小麦粉 ・ねぎしのハンバーグをポローン ・創作昔話「がんバくん」 ・YouTube 500万再生！ 　【東方MV】患部で止まってすぐ溶ける～狂気の優曇華院【IOSYS】 ・YouTube 100万再生！ 　「電波的妄想美少女Q」 　歌唱：KOTOKO 　作詞・作編曲：MARON ・ウイマーマサーガ700万再生 ・今の中国語は嘘です ・もっと！孕ませ！炎のおっぱい異世界 おっぱいスパイ学園！ ・タイトルがイカれとるな ・CG監修がミニョンさん ・トロントはカナダのどっちなんだい ・ミニョンさんのページ見てたからイベント情報がまったく頭に入ってこなかった ＜Aパート＞ ・ふつおたです ・GWはけものフレンズ ・金ビキニはいつ着てもいいからね ・おかゆんさんの金ビキニ放送 ・妄想するっていいですよね ・久々にマイクラやりたい ・プレイヤーキャラはおじさんばかり ・海は整えなくても平らでしょ ・ミリオンは合計6カ所です ・ブルアカ横浜中華街コラボ ・チーパオとチャイナ服の違い ・餃子とシューマイの違い？ ・漫才やりますか ・漫才やって体温上げていこう ・ちょっとだけアレンジしました ・シン正月とは ・人類お正月化計画 ・カオスだったな ・片玉で守られた部分ってどこ？ ・映像があってよかった ・あれはリツコさんだからね ・​​タイピング補完計画 ・なんで真矢みきなんでしょうか？ ・ハイコンテクスト ＜Bパート＞ ・みつをたです ・エヴァが繋がった ・今すぐ病院に行ってください ・創作昔話　ごんきつね ・ゴールデンボールじゃないか ・1週間出っぱなしだったか ・7つもいらないでしょ1個で十分 ・創作おとぎ話　赤穂忠臣蔵　第十三夜　第二部 ・エピローグに続く ・大石が斬っちゃった ・明坂聡美さん、ご結婚おめでとうございます！ ・ナイフを持った女性声優の画像 ・にじさんじピックアップニュース ・サメは哺乳類 ・資格は若いうちに取れ ・子供たちに伝えたいことが大人に刺さる ・鼠径部だと思ってた ・ぬるぽ放送局の切り抜き動画 ・やはり、mixi2ですか？ ・ホロピックアップニュース ・栃木未来大使とは ・買った覚えのないガンプラがうちに届く ・Vピックアップニュース ・VJ KOO ・そろそろAI MOC出来そう ・AIはかせは出来そう ・サンプラーでよかった ・さすがイオシス早いなー ・AIはかせ「一旦、CMで～す」 ＜エンディング＞ ・VJ KOOもサンプラーなのでは？ ・安く済ませたい方お待ちしてます ・バニーガーデン２に新衣装が ・ご奉仕バニーとは ・はかせがXでスペースやってます

ลองจินตนาการถึงภาพที่แปลกประหลาดที่สุดในโลกเทคโนโลยีดูครับ วันที่ 3 ยักษ์ใหญ่ที่เกลียดกันเข้าไส้อย่าง Apple, IBM และ Motorola ยอมจับมือกันเพื่อสร้างสุดยอดชิปประมวลผล “PowerPC” ที่หวังจะฆ่า Intel ให้ตายคาสนามรบ ตอนแรกมันคือโปรเจกต์แห่งความหวัง ชิปแรงทะลุปรอทจนช่วยกู้ชีพ Apple ในยุคตกต่ำได้สำเร็จ แต่ใครจะไปคิดครับว่า อภิมหาโปรเจกต์นี้จะจบลงด้วยความล้มเหลวแบบพังพินาศ ชิปร้อนจัดจนแทบหลอมละลาย และบีบให้ Apple ต้องยอมกลืนน้ำลายตัวเอง เดินไปซบศัตรูตลอดกาลอย่าง Intel แต่ความตลกร้ายของประวัติศาสตร์ก็คือ ความพ่ายแพ้ที่เจ็บปวดในวันนั้น กลับกลายเป็นจิ๊กซอว์ชิ้นสำคัญที่ทำให้ Apple ก้าวขึ้นมาเป็นจ้าวแห่งชิปประมวลผลของโลกด้วยตระกูล M-Series ในปัจจุบันได้อย่างไร ไปหาคำตอบกันครับ เลือกฟังกันได้เลยนะครับ อย่าลืมกด Follow ติดตาม PodCast ช่อง Geek Forever's Podcast ของผมกันด้วยนะครับ #ประวัติApple #ชิปPowerPC #AppleSilicon #สงครามชิป #สตีฟจอบส์ #กรณีศึกษาธุรกิจ #ประวัติศาสตร์เทคโนโลยี #คอมพิวเตอร์ #ธุรกิจเทคโนโลยี #ชิปM1 #เรื่องเล่าธุรกิจ #ความรู้ธุรกิจ #geekstory #geekforeverpodcast

O "Ulrich Responde" é uma série de vídeos onde respondo perguntas enviadas por membros do canal e seguidores, abordando temas de economia, finanças e investimentos. Oferecemos uma análise profunda, trazendo informações para quem quer entender melhor a economia e tomar decisões financeiras mais informadas.00:00 – Começou00:25 - A rejeição de Messias e desdobramentos na eleição06:07 - Decisão do Copom sobre a queda da Selic09:15 - Conflitos no Oriente Médio e bloqueio de Ormuz12:55 - Saída dos Emirados Árabes da OPEP15:57 - Resiliência da Rússia frente às sanções17:42 - Possível interferência dos EUA na política brasileira20:12 - Financiamento de IPOs e sinais de topo de mercado22:21 - Intervenção do Japão para defender o Iene25:50 - Recomendação e diversificação em fundos imobiliários FII27:07 - Concentração de portfólio por fator (Bitcoin)28:33 - Riscos subestimados pelo mercado30:50 - O que fazer com a queda do dólar32:10 - Próxima indicação ao STF32:42 - Impacto da guerra no preço dos alimentos33:38 - Novidades sobre a OranjeBTC (OBTC3)35:19 - Como é criada a moeda bancária (M1)36:23 - Economics dos tokens e futuro da IA39:15 - Existe inflação cultural de preços?41:22 - Inflação do Milei não caiu por que?43:07 - Imigração para China vs. Estados Unidos43:54 - O ouro perderá valor para o Bitcoin no futuro?45:22 - Opinião sobre o livro "A Revolta de Atlas"47:13 - Principais teóricos sobre ciclos de mercado

Help Stop The Genocide In American Ghettos Podcast is a platform for ordinary law abiding citizens from Emmanuel Barbee friends list and from his social groups who are Black Artists, African Artists, Allied Healthcare professionals, Church Leaders, and Black Entrepreneurs, African Entrepreneurs who want to promote their products and services to our listeners from the global community. This no holds-barred talk show focuses on promoting Grassroots Community Advocacy, Business, Finance, Health, Community-Based Solutions, Employment, Social Issues, Political Issues, Black Issues, African Issues and Christianity which speaks to the interests of our listeners. Broadcasting on multiple social networks throughout the United States and around the globe. This show will provide insight on how our creative abilities can be used to create economic tangibles in our communities, neighborhoods and in Black countries. The Grass Roots Community Activist Movement is about uniting the low income Black Community with the African Immigrant Community starting in Chicago and eventually throughout the Diaspora. Emmanuel is not just online to sell his Revised Book and items from his Virtual Store or just trying to get donations for his Film Project but rather his aim is to recruit like minded Black Americans, like minded African Immigrants from 10 African nations within in the United States of America to assist him in building the best Black Christian Business within the United States called the Grass Roots Community Activist Institute of Chicago. Our objective is for us to build our own network, our own Community Grocery Store, Community Healthcare Clinic and Community Housing. #NotAnother34Years, #M1, #DAS-FM, #JoinGRCAM

ぬるぽ放送局おたより投稿フォーム https://forms.gle/6tbmBzK6wbyavJG47 2026年5月パワープレイ M1. One Era feat. DD"ナカタ"Metal Produced by RoughSketch Vocal by DD"ナカタ"Metal 収録アルバム：NBCD-052 20 Years Of RoughSketch: Golden Best & Remixes 2026 2026・4・26 Release https://notebookrecords.net/discographyportal.php?cdno=NBCD-052 番組時間：98分27秒 出演者：夕野ヨシミ、たくや VOICEVOX:ずんだもん VOICEVOX:四国めたん ---- 2026/4/30に公開録音したものを配信いたします。 ラジオ記事はリスナーのEEチャンピオンさんが書いてくれているので楽してます。 ＜オープニング＞ ・ぬるぽは野球中継のため開始時間を延長しています ・阪神園芸？？何？誰？ ・すすきのストリップバーって言っちゃったよ ・M3行ってきましたね ・今日は夕野さんいないんですねって3人に言われたよ ・中身は46歳のおじさんなんだよね ・サコッシュ完売 ・みんなが求めていたのはサコッシュ ・MP3ならだいぶ入ります ・モノラルMP3 ・10倍でステレオだよ ・5.1倍じゃないの？ ・0.1はマラカスの妖精さん ・トラクターにはハードコア ・M3があったり祝日があったりで曜日感覚がなくなってる ・イオシスくんの最新情報 ・ゲーム『ゆんゆん電波シンドローム』2026/4/24 Steamにてリリー　ス！ 　書き下ろし楽曲 　・YUNYUN HARDCORE 　・幸福絶頂!! りむ・で・らてんと☆ 　・電波的妄想美少女Q 　DLC収録曲 　・お願い！コンコンお稲荷さま 　・ウサテイ 　・スカ警24時 　・お嫁にしなさいっ！ 　・わかさぎ姫の～寿司 ・D.wattの「クラブ怖い」は怖い ・2026/5/4 令和八年（第二十三回）博麗神社例大祭 　at 東京ビッグサイト　東ホール 　■IOSYS え28ab 　「魔理沙は大変なものを盗んでいきました」20周年！新装版5タイトル 　M3では完売した「ぬるぽ18」「謎の名刺」も搬入します ・タコ焼きケータリングの前にいます ・飲食物の差し入れはご遠慮していますのでご注意ください ・親のジャケットより見てる ・霊夢のケツはDLして見てください ・ごっすんリミックスの１・２がぼやーっとしてるのは正解です ・20個全部買ってください！ ・さようならDVD-R ・全部で300万円用意してください ・お品書きは無料配布します ・よくわからなくてたまごいっぱい買っちゃうやつだ ・山に入るときは蛍光色を着ていこう ・たまご5点買ったらどうなります？ ・おつりは4万円あります ・前日のイベントが22時終わりのD.wattは現れるのか ・「東方LostWord」 　提供曲が『JOYSOUND』で2026/4/30カラオケ配信されました！ 　「祭月夜／東方LostWord feat.成瀬瑛美+恋汐りんご from バンドじゃないもん!MAXX NAKAYOSHI × IOSYS」 　「(TT)プレシャスワード／東方LostWord feat.桃井はるこ × IOSYS」 ・「天才マイクロモラトリアム」MV公開中！ ・100回でいいので見てください ・白と肌色ご覧ください ・IOSYSブースに敷いてある布が新しくなりました ・らふさんの特典ポストカードはなくなりました ＜Aパート＞ ・ふつおたです ・どんなGWをお過ごしですか？ ・26年ぶりの真狩温泉 ・実家のたかし？ ・ネコは例大祭の戦いに付いていけないので実家に置いてきた ・最近見ましたか細川たかしさんのMV ・スマホと靴と体にまく新聞紙があれば例大祭は大丈夫 ・夕野ヨシミ約20周年 ・魔心（まごころ）サリーさんの転売ヤーVS思想の強い店長さんシリーズ ・ファンボックスで、ぬるぽの補足をしたらいいのでは？ ・イオシスロードショーのおすすめの映画 ・マーシーAI裁判 ・みんなでマーシーを見ましょう ・え？1割合ってるの？ ・チャンネル登録者は1000人になりました ・ショート動画いいよね ・あやめさんのショート動画 ・「さすがです」と「こわ」 ・だいたいフォローしてる夕野さん ・イオシスブルアカ放送局 ・はじめるきっかけのスバルさんは？ ・コトリちゃん可愛いですよね ・ゲームの話 ・PUKEY GODDESS SHOT TRICK ・これも夕野さん巡回済みなんだ ・バックショットルーレットはウィッシュリストには入ってないか ・アルケミーファクトリーが楽しすぎて ・作詞家から作塩家に ・例大祭で塩を売ろう ＜Bパート＞ ・ハードですねー ・両極端すぎるな ・みつをたです ・デレマスくんのサイバーウィッチの衣装 ・センシティブファルダをまとめてzipでうｐ ・プラグマタのディアナちゃん ・でも、今アルケミーファクトリーやってるから ・にじさんじピックアップニュース ・角煮EDM ・ラジオ巌流島の話始めていいの？ ・あらゆるジャンルの男の娘のふり ・ジョー力一さん ・夕野ヨシミ巡回済みじゃない選手権やるか ・ホロピックアップニュース ・まつり「じゃあ、今脱いで！」 ・Vピックアップニュース ・あおぎり高校もきましたよ ・まばたきも睡眠もできない ・若手芸人ピックアップニュースもやるかな ・赤穂忠臣蔵は休載です ・ごんぎつねもお休みです ＜エンディング＞ ・GW明けまでギブアップせずポローンしましょう ・今回は長めの東京出張 ・東京行くとR-1を飲む ・ねぎしの新作のハンバーグみたいなやつが美味いらしい ・ねぎしに行きたいと思います ・ねぎしのトップページに怪文書？ ・体調を崩すといけないので220gにしよう ・GWがんばっていこう！

Help Stop The Genocide In American Ghettos Podcast is a platform for ordinary law abiding citizens from Emmanuel Barbee friends list and from his social groups who are Black Artists, African Artists, Allied Healthcare professionals, Church Leaders, and Black Entrepreneurs, African Entrepreneurs who want to promote their products and services to our listeners from the global community. This no holds-barred talk show focuses on promoting Grassroots Community Advocacy, Business, Finance, Health, Community-Based Solutions, Employment, Social Issues, Political Issues, Black Issues, African Issues and Christianity which speaks to the interests of our listeners. Broadcasting on multiple social networks throughout the United States and around the globe. This show will provide insight on how our creative abilities can be used to create economic tangibles in our communities, neighborhoods and in Black countries. The Grass Roots Community Activist Movement is about uniting the low income Black Community with the African Immigrant Community starting in Chicago and eventually throughout the Diaspora. Emmanuel is not just online to sell his Revised Book and items from his Virtual Store or just trying to get donations for his Film Project but rather his aim is to recruit like minded Black Americans, like minded African Immigrants from 10 African nations within in the United States of America to assist him in building the best Black Christian Business within the United States called the Grass Roots Community Activist Institute of Chicago. Our objective is for us to build our own network, our own Community Grocery Store, Community Healthcare Clinic and Community Housing. #NotAnother34Years, #M1, #DAS-FM, #JoinGRCAM

Empire of Lies: Making an Indie Thriller on a Shoestring with Matthew Hope & Joseph Millson What happens when an established action director strips everything away to make a micro-budget thriller in just 8 days? This week on The Filmmakers Podcast, Giles Alderson sits down with director Matthew Hope (The Veteran, All the Devil's Men) and returning champion, actor/producer Joseph Millson (Casino Royale, Signs of Life), to discuss their tense new two-hander, Empire of Lies. Matthew and Joseph pull back the curtain on true guerrilla filmmaking. They break down what it is actually like to shoot a feature film in under 10 days with a crew of just 4 to 5 people, the realities of self-financing (including how Matthew pitched the investment to his wife!), and how an epiphany on the M1 motorway finally cracked the script. We also do a massive deep dive into the business side of indie film, exploring how they utilized data analytics, Instagram, and targeted ads to independently distribute a sub-£100k movie into cinemas. If you are waiting for permission or a massive budget to make your first feature, this episode will give you the kickstart you need to just go out and shoot it!

OsteoBites welcomes Caroline Maloney, MD, PhD, from the Medical College of Wisconsin, who will discuss her research on surgery-accelerated metastasis and developing perioperative therapies.Pulmonary metastasis remains the major cause of death in osteosarcoma. The timing of metastatic relapse defines clinically meaningful subgroups in osteosarcoma with patients who relapse within 6–12 months of surgical removal of their primary tumor having markedly worse survival (10-20%) than those who relapse after completion of therapy (40-50%). While surgical removal of the primary tumor is a fundamental component of the clinical care of solid tumors, surgery induces transient but profound changes in immune and inflammatory responses that can paradoxically accelerate the growth of metastatic disease. Dr. Maloney has demonstrated that surgical removal of the primary tumor accelerates the growth of pre-existing pulmonary metastatic disease and promotes expansion of M2‐like macrophages in the lung microenvironment. Strikingly, short term perioperative treatment with a RIPK2 inhibitor blocks this effect and reprograms macrophages toward an M1-like phenotype, implicating the NOD2–RIPK2 innate immune pathway as a key mediator of post‐surgical immune reprogramming. In contrast, the NOD2 agonist Mifamurtide has shown clinical efficacy when administered as adjuvant therapy to metastatic osteosarcoma patients after primary tumor resection. This data suggests that NOD/RIPK2 signaling may exert context-dependent effects, promoting either pro- or anti-tumor myeloid responses depending on the timing of activation relative to surgery. Understanding how surgical tumor removal alters systemic innate immunity and how RIPK2 signaling orchestrates these responses could identify new strategies to prevent early pulmonary relapse after surgery.

Ak si chce podnikateľ pri kúpe nového auta odpočítať DPH, od januára nastali zmeny. Pribudli nové obmedzenia a povinnosti, ktoré však môžu pôsobiť zmätočne. Platí, že sto percent DPH si môže odpočítať len ten podnikateľ, ktorý auto využíva výlučne na podnikateľské účely a zároveň vedie elektronickú knihu jázd. Daňová expertka Ľubomíra Murgašová zo spoločnosti Grant Thornton v rozhovore upozorňuje, že ak podnikateľ spraví chybu pri vedení knihy jázd, stratí nárok na celý odpočet DPH. Treba myslieť na to, že táto evidencia už musí byť elektronická a nie papierová. „Najviac sa to podobá GPS. Treba tam napísať VIN číslo vozidla, meno šoféra, stav kilometrov na začiatku a konci každej jazdy i mesiaca a účel cesty,“ vysvetľuje expertka. Elektronickú knihu jázd treba viesť presne, pretože daňová kontrola ju môže porovnávať so záznamami napríklad z diaľničných kamier. Taktiež si môže overiť účel stretnutia u druhej strany a všetko musí sedieť. Podľa Murgašovej budú daňové kontroly naozaj detailné, pretože štát môže vďaka týmto zmenám získať významné zdroje do štátneho rozpočtu. Správca dane vie, ktorí podnikatelia si uplatňujú stopercentný odpočet DPH, pretože mu to musia nahlásiť. Zároveň je ich menej ako tých, ktorí sa rozhodnú len pre polovičný odpočet. Podľa expertky však takto nastavené obmedzenie plného odpočtu DPH porušuje zásadu daňovej neutrality. Ak totiž podnikateľ využíva služobné auto na 90 percent na podnikanie a iba desať percent na súkromné jazdy, stále si môže odpočítať len 50% DPH. Zákon v tejto súvislosti tiež rozlišuje medzi konateľom a zamestnancom. Zatiaľ čo konateľ si môže vykázať jazdu z domu do práce ako služobnú, pri zamestnancovi to neplatí. Ak má čisto služobné auto slúžiť zamestnancovi, v noci musí byť zaparkované pri pracovisku. Systém je pomerne komplikovaný a väčšina podnikateľov sa rozhodla pre režim len polovičného odpočtu DPH. „Ak sa niekto nechce stresovať s tým, že nemôže na služobnom aute ani dieťa zaviesť do školy, tak si vyberie režim polovičnej DPH a pri účtovaní pohonných látok pre účely dane z príjmu zasa systém 80:20. Je to pohodlnejšie.“ V zákone je zároveň priestor, ktorý sa dá označiť ako diera v prospech majiteľov veľkých vozidiel, na ktorých sa vozia aj súkromne. Obmedzenie odpočtu DPH sa totiž vzťahuje len na kategórie M1, L1e a L3e — teda osobné autá a niektoré motocykle. Na nákladné vozidlá v kategórii N1 si však podnikateľ stále môže odpočítať plnú výšku DPH tak ako doteraz. Do tejto kategórie však patria aj modely, ktoré mnoho ľudí využíva na bežné súkromné jazdy. Sú to značky ako Ford Ranger, Toyota Hilux, alebo Nissan Navara, či Volkswagen Amarok. Niektorí výrobcovia ponúkajú osobné modely následne upravené a preklasifikované do kategórie N1 — napríklad SUV modely ako Kia Sportage či Sorento, alebo kombíky doplnené o predpísanú priečku medzi nákladovým a osobným priestorom. Aj pre tých platí starý režim odpočtu DPH. Počas používania auta vo firme sa jeho účel môže meniť zo služobného na súkromné a naopak. Ľubomíra Murgašová odpovedá, ako v tom prípade postupovať pri účtovaní DPH. Moderuje Eva Mihočková.See omnystudio.com/listener for privacy information.

Help Stop The Genocide In American Ghettos Podcast is a platform for ordinary law abiding citizens from Emmanuel Barbee friends list and from his social groups who are Black Artists, African Artists, Allied Healthcare professionals, Church Leaders, and Black Entrepreneurs, African Entrepreneurs who want to promote their products and services to our listeners from the global community. This no holds-barred talk show focuses on promoting Grassroots Community Advocacy, Business, Finance, Health, Community-Based Solutions, Employment, Social Issues, Political Issues, Black Issues, African Issues and Christianity which speaks to the interests of our listeners. Broadcasting on multiple social networks throughout the United States and around the globe. This show will provide insight on how our creative abilities can be used to create economic tangibles in our communities, neighborhoods and in Black countries. The Grass Roots Community Activist Movement is about uniting the low income Black Community with the African Immigrant Community starting in Chicago and eventually throughout the Diaspora. Emmanuel is not just online to sell his Revised Book and items from his Virtual Store or just trying to get donations for his Film Project but rather his aim is to recruit like minded Black Americans, like minded African Immigrants from 10 African nations within in the United States of America to assist him in building the best Black Christian Business within the United States called the Grass Roots Community Activist Institute of Chicago. Our objective is for us to build our own network, our own Community Grocery Store, Community Healthcare Clinic and Community Housing. #NotAnother34Years, #M1, #DAS-FM, #JoinGRCAM

This episode explores the current state and future of electric vehicle charging infrastructure along the UK strategic road network, focusing on the M1 corridor in particular.Gary discusses charging patterns, infrastructure growth, and strategic considerations for EV drivers.Key topics- Growth of EV charging infrastructure on the M1 and strategic road network- Charging patterns and peak times for EVs along the M1- Current gaps and future opportunities for charging hubs outside motorway service areasResourcesZapMap - https://zapmap.com/Fastned - https://fastned.co.uk/Ionity - https://ionity.eu/Shell Recharge - https://shellrecharge.com/The EV Musings Podcast is sponsored by Zapmap, the go-to app for EV drivers, helping you find and pay for public charging with confidence.Episode produced by Arran Sheppard at Urban Podcasts: https://www.urbanpodcasts.co.uk(C) 2019-2026 Gary ComerfordSupport me: Patreon Link: http://www.patreon.com/evmusingsKo-fi Link: http://www.ko-fi.com/evmusingsThe Books:'So, you've gone electric?' on Amazon : https://www.amazon.co.uk/dp/B07Q5JVF1X'So, you've gone renewable?' on Amazon : https://amzn.to/3LXvIckSocial Media:EVMusings: Twitter https://twitter.com/MusingsEvInstagram: @EVmusingsOctopus Energy referral code (Click this link to get started) https://share.octopus.energy/neat-star-460Upgrade to smarter EV driving with a free week's trial of Zapmap Premium, find out more here https://evmusings.com/zapmap-premiumMentioned in this episode:ZapmapThe EV Musings Podcast is sponsored by Zapmap, the go-to app for EV drivers, helping you find and pay for public charging with confidence. Zapmap is free to download and use, with subscription plans for enhanced features such as using Zapmap in-car on CarPlay or Android Auto, and discounted charging across thousands of charge points. Download the app from the Apple App Store or Google Play Store or find out more at www.zapmap.com.Zapmap EV GuideZap Map Trial

Magyar Péter a tegnap reggelt a Kossuth Rádióban kezdte, majd az M1-nél folytatta, az MTVA épületének egyik aulájában több dolgozó megtapsolta. A HVG megtudta, szerda délután állománygyűlést tartott a csak Pitbullként emlegetett M1-es hírigazgató, Németh Zsolt. Sulyok Tamás köztársasági elnök Magyar Pétert javasolja miniszterelnöknek. Trump is elmondta a véleményét a Tisza Párt elnökéről. A honvédség elkezdte visszavonni azokat a katonákat, akiket a különböző energetikai létesítményekhez rendeltek korábban. Kezdje a napot a HVG hírpodcastjával!

On Wednesday, as fuel protests over the Government's response to rising petrol and diesel prices entered their third day it became clear the demands of the protesters showed no signs of being met.Taoiseach Micheál Martin said fuel protesters blocking cities and towns around Ireland are “wrong” and those breaking the law will be penalised.Several distinct but co-ordinated protests took place over the past three days, involving slow-moving convoys on motorways, such as the M1 and M50, as well as the blocking of main roads in Dublin.Those taking part include hauliers and agricultural contractors using large trucks and tractors to disrupt traffic.Irish Times political editor Pat Leahy analyses the political reaction to the protesters and Colm Keena explains who the protesters are and what they want.Presented by Bernice Harrison. Produced by Suzanne Brennan. Hosted on Acast. See acast.com/privacy for more information.

The fuel protests have entered a new phase — Gardaí say they're now “blockades”, not protests, and the Defence Forces could be brought in to clear key routes and fuel depots. With the M1 and even the M50 being shut down, are the protesters after going too far… or is this the only way to get the government to listen? Adrian and Jeremy take live callers from both sides: small business owners being “crucified” by costs, families missing flights, and one caller saying her child's medication is being delayed. Tempers flare, opinions split, and the debate turns to how long public support will really last.

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia. Often overlooked, microglial cells are the brain's immune system and play a central role in determining whether the brain thrives or degenerates over time. Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer's, Parkinson's, and more. Most importantly, this episode highlights how everyday lifestyle choices — from diet and exercise to metabolic health — directly influence brain function and long-term cognitive resilience. Join us as we delve into: What microglia are and why they control brain health The difference between M1 (destructive) and M2 (protective) states How metabolism shapes the brain's immune response Why conditions like Alzheimer's are rooted in immune dysfunction The connection between blood sugar, insulin, and brain degeneration This episode is for you if: You want to protect your brain and prevent cognitive decline You're interested in the science of Alzheimer's and neurodegeneration You want actionable strategies to improve brain health You're curious about the future of brain optimization and longevity You can also find this episode on… Youtube: https://youtu.be/EMrlchMOZKk Find more from Dr. David Perlmutter Website: https://www.drperlmutter.com Book: https://braindefenders.com LinkedIn: https://www.linkedin.com/in/david-perlmutter-md/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMd/ Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Herbie Farnworth joins us for a game It's Fish Doorbell Season Matt's hurt his back.. Abby knows how to fix The M1! See omnystudio.com/listener for privacy information.

Get the full episode here: https://www.10percenttrue.com/pricing-plans/list10PCT EP86 P1 – Benji PrefontaineChapters0:00 Intro Teaser – M1.3 Corner Speed, Avoiding the Merge, Low Level3:00 Welcome, Benji4:15 Subscriber Question (T-Stoff) – Super Étendard Carrier Ops10:35 The Hardest Flying of His Career?13:44 Route to the Air Force16:15 Initial Flying & Training Curriculum19:04 Early Impressions & Developing Mission Focus23:48 Choosing a Platform & Mission27:10 Explaining Career Choices29:15 The Mirage 2000N Mission31:32 Revisiting the Training Accident & Its Repercussions36:14 Ready for That Conversation?38:44 The Reward for That Risk40:22 Alpha Jet46:36 Air-to-Air Phase – How Formative?49:18 Armée de l'Air Culture56:00 Parents' Opinions57:37 Mirage F1CT – Introduction, Impressions & Capabilities1:06:05 Electronic Warfare Suite1:07:40 MATRA 530 – Fox 1 Capability1:13:53 Were Export F1 Variants Better?1:17:00 Diving Deeper into EW Capabilities1:20:42 M1.3 Corner Speed – Avoiding the Merge at Low Level1:23:34 “Cheating” in the F1?1:26:10 DACT Opportunities1:27:57 Taking on the Mirage 20001:30:48 Recce & Air-to-Ground Role1:36:45 ELINT System Autonomy & Mission Planning1:40:26 Datalink1:41:50 Flying Qualities (and Vices) of the F11:46:04 Bird Strikes1:48:20 Experience on the F1CT & Close Calls1:50:58 Air-to-Air Refuelling – Tankers, Techniques & Night Ops2:02:15 Geeking Out & Previewing the Next Episode

Bienvenidos a un repaso profundo por una de las rivalidades más apasionantes de la historia del automovilismo. Hoy en Garaje Hermético analizamos dos coches que nacieron de una carambola del destino. Ni BMW ni Mercedes-Benz tenían planeado crear estas berlinas deportivas tal y como las conocemos, pero la competición los obligó a superar todos los límites de la ingeniería de los años 80. El origen: De los rallies al asfalto La historia del Mercedes 190E 2.3-16 comienza con una obsesión: demostrar que el chasis W201 era el mejor del mundo. Mercedes quería volver a los rallies y encargó a Cosworth el desarrollo de una culata de 16 válvulas para su bloque M102. El resultado fue brillante, pero la irrupción de la tracción total de Audi cambió las reglas del juego. Mercedes, entendiendo que la propulsión trasera no podría competir en el barro, pivotó hacia el DTM (Campeonato Alemán de Turismos). BMW, al ver el despliegue técnico de Stuttgart, no se quedó atrás. Bajo la dirección de Paul Rosche —apodado "Paul Árboles de Levas"—, BMW Motorsport desarrolló el motor del M3 en un tiempo récord de dos semanas, adaptando la arquitectura del motor del M1 para encajarla en el vano del E30. Mercedes 190E 2.3-16: Sobre-ingeniería alemana Mercedes invirtió una cifra astronómica para la época en el desarrollo del "Baby Benz". Querían un coche indestructible. Para demostrarlo, antes de su lanzamiento, llevaron tres unidades a Nardò (Italia), donde rodaron 50.000 kilómetros sin parar a una media de casi 248 km/h. En la pista, el 190E destaca por su innovadora suspensión trasera multibrazo de cinco brazos. Es un coche que "pisa" de forma impecable, filtrando las irregularidades pero permitiendo ritmos inconfesables con una nobleza absoluta. Su motor Cosworth de 185 CV es elástico y lineal, ideal para cruzar continentes con total confianza. BMW M3 E30: El purasangre de Múnich Si el Mercedes es un guante de seda, el M3 es un bisturí. A diferencia del 190E, el M3 cambió casi todos sus paneles exteriores respecto al Serie 3 convencional por motivos aerodinámicos (solo comparte capó y techo). Su motor S14 de 4 cilindros y 2.3 litros entrega 200 CV con un carácter puramente de carreras. Es un coche más ligero y directo; su tren delantero muerde el vértice de las curvas con una agresividad que el Mercedes no busca. Es un vehículo que exige más del conductor, pidiendo trabajar constantemente con el cambio Getrag de primera hacia atrás para mantener el motor en la zona alta del cuentavueltas, donde el aullido metálico de su admisión se vuelve adictivo. La escalada de los Evolution La rivalidad no se detuvo en los modelos base. Para ganar en el DTM, ambas marcas lanzaron ediciones especiales cada vez más radicales. Desde el Mercedes 2.5-16 hasta el imponente Evo II con su alerón masivo, y desde los primeros Evolution de BMW hasta el Sport Evolution (Evo III) de 238 CV. Fue una lucha por la supremacía técnica que nos dejó algunos de los mejores coches de calle jamás fabricados. Conclusión: ¿Cuál interesa más hoy? Ambos son historia viva del motor. El BMW M3 E30 se ha convertido en el estándar de lo que debe ser un coche deportivo: ligero, comunicativo y rabioso. Sin embargo, en el mercado actual de clásicos, el Mercedes 190E 2.3-16 (o el posterior 2.5) se presenta como la compra más inteligente. Ofrece una calidad de construcción legendaria, una fiabilidad superior para el uso real y una experiencia de conducción que combina la sofisticación de Mercedes con el picante de Cosworth, todo ello a un precio que todavía no ha alcanzado las cotas prohibitivas del M3. Sin la existencia de uno, el otro no habría llegado a ser tan perfecto. Son dos formas distintas de entender la velocidad que nacieron para batirse en duelo y terminaron convirtiéndose en leyendas inseparables.

ぬるぽ放送局おたより投稿フォーム https://forms.gle/6tbmBzK6wbyavJG47 2026年3月パワープレイ 「ウィマーマ・サーガ」 歌：しぐれうい (9) vs. しぐれうい (16) 作編曲：D.watt 作詞：まろん 2026・1・4 Release https://linkco.re/H71G5cG0 https://www.youtube.com/watch?v=SNM7Rl8F1QU 番組時間：88分53秒 出演者：夕野ヨシミ、たくや、はかせ VOICEVOX:ずんだもん VOICEVOX:四国めたん ---- 2026/3/19に公開録音したものを配信いたします。 ラジオ記事はリスナーのEEチャンピオンさんが書いてくれているので楽してます。 ＜オープニング＞ ・はかせだかんーな ・かんなさん、ふっくらしました？ ・イオシスくんの活動報告 ・大事な話は最初がいい ・コラボイベントBGMを制作しました！ 　『 #東方幻想エクリプス 』×『 #ゴシックは魔法乙女 』 　「Especial Magic」 　原曲：恋色マスタースパーク 　編曲：コバヤシユウヤ(IOSYS) 　ギター：三浦公紀 ・そういう感じの番組だっけ？ ・弊老舗サークル ・あーマイクが ・離席する演者 ・映りこみに行く夕野ヨシミ ・提供楽曲にMVがついたぞのお知らせ 　「KP all the way／亞生うぱる・雨庭やえ・音門るき(VEE)」 　作詞：七条レタス 　作編曲：D.watt ・楽曲提供のお知らせ 　「New World, New Era／PASTEL RADIO」 　作編曲：uno(IOSYS) 　作詞：オミ織葉 　ギター：NUE ・Log Ridersが面白い ・我々はリモート慣れしてるから ・本日はリモートレスでお送りしてます ・アルコールは飲んじゃった ・YouTube 100万再生おめでとうございます！ 　【original MV】お嫁♡HOLIC【hololive/ネリッサ】 　ボーカルと英語作詞 : ネリッサ・レイヴンクロフト 　作詞 : かたほとり 　作曲・編曲 : ARM ・はかせ、マイク、マイク ・真実はいつもツムツム ・YouTube 1500万再生おめでとうございます！ 　【original anime MV】A Horny Money World ~伝説の夜~【hololive/　宝鐘マリン】 　作詞：まろん 　作編曲：D.watt ・1再生1円にならないかな？ ・土日はUDXでイベントだったわ ・コアックマ・アックマの放送は明日の14時です ・チャンネルはそのままで ・チャンネルを回すとは？ ＜Aパート＞ ・はかせ、今何食べたいですか？ ・豚丼じゃないんだ ・あのCMは10年前 ・500円のために毎回出てほしい ・今からCM撮っちゃお ・低予算って言わない ・いつの「なるほどねー」なの？ ・え？飲みに行きます？ ・15年前は平成じゃん ・クイズ収録は10年後 ・ふつおたです ・山形は梅は咲いてます ・ネタはないのはまずいじゃん ・宦官では話題が広がらない ・また玉の話してる ・ミュート助からないの逆 ・誰か杉切って来いよ ・ギャバンのおすすめポイント ・よろしく勇気 ・マクロスFは昭和ではない ・メカトキにニチアサは、まだ早い ・アンパンマンのハードなストーリーとは ・体だけのアンパンマンが怖い ・後のマミさんである ・アンパンマンは雇用契約なんだ ・上坂すみれプロレスデビューの話 ・無機物でもチャンピオンに ・詳細な情報ありがとうございます ・確認待ちのコメントが大量に ・相撲やりに国技館に？ ・ドキッ親方だらけの両国国技館 ・イオシスのウィキペディアの話 ・写真しかないはかせのプロフィール ・イベント出演の半分はロフト ・zepp羽田の行きにくさ ・最近流行りの漫才のコーナー ・はかせと漫才やります ・ラーメン畑とは ・週に2回も食べてるのにラーメンの歴史を知らない？ ・1回も合わせてないのにちゃんと出来た ・二郎系に行くほど若くない ・隠れて違法ラーメンを食べてるんですね ・ラーメンの味を覚えてしまったイノシシ ・イオシスライブやってみては？ ・M1締め切り当日はさすがに出ない ・2分でウケるネタはむずかしい ・結局ラーメン畑ってなんなの？ ＜Bパート＞ ・どうなんっすか ・新鮮なウイマーマ畑から採ったウイマーマ ・みつをたです ・クラークって何した人だっけ？ ・クラーク「ラッキーピエロはあっちやで」 ・フワワちゃんのふわわがたわわに ・髪が貫通はあるよね ・このコーナーは自由です ・慎ましいお胸の横乳 ・創作おとぎ話　赤穂忠臣蔵　第八夜 ・江戸で同人活動はおかしい ・浅野も吉良も生きている ・作者の名前も残ってるんだね ・最終回はOVA ・ホロピックアップニュース ・おかゆさんは世界ランカー ・ラムベガス遊べるんだ ・あれ？夕野さんの世界線違う？ ・2連覇ならなかったね ・日本は実質2位なのでは？ ・はかせの窓をChatGPTで作ってみては？ ・EDは虚無なので、はかせにまかせます ＜エンディング＞ ・あのMOCさんも10年前 ・抗えないんかーんな ・久しぶりのはかせゲスト回でした ・HAHAHA！世間話だこれ！ ・今日は無遅延 ・後枠に行こう

Tom and Jeff are back with a packed episode that wanders from Apple hardware to Apple history to Apple TV+ sports to, well, a scientific fart study. If that sounds like a lot, it is.Topics covered this episode:MacBook Neo hands-on — Tom got a brief look at the new $599 MacBook Neo at an IT conference. Build quality impressions, the Indigo color, and why the "it's just an iPhone chip" skepticism sounds a lot like what people said about the original M1 with 8GB of RAM. (Spoiler: they were wrong then too.) David Pogue's Apple: The First 50 Years — Tom pre-ordered it, it arrived while he was out of town, and he's had exactly 15 minutes with it. It's a 600-page textbook-style history (not a glossy coffee table book), and he's planning a more thorough read over the summer. A history tangent worth taking — The origin story of the PowerBook's palm rest design — and how one engineer's persistence against resistance accidentally shaped every laptop keyboard layout that followed.Jeff discovers F1 — Apple TV+ now carries every F1 race, and Jeff is in. The tech angle (real-time telemetry, PlayStation-style steering wheels, hybrid power transitions) makes it surprisingly interesting.The Human Flatus Atlas — Jeff has enrolled in a legitimate University of Maryland research study on human flatulence. Smart underwear device incoming. Butt tag update promised for next episode.Links from the showTom's Photos of the MacBook NeoApple: The First 50 Years – David PogueHuman Flatus Atlas ProjectF1 on Apple TV+Question or Comment? Send us a Text Message!Contact Us Drop us a line at feedback@basicafshow.com You'll find Jeff at @reyespoint on Threads and reyespoint.bsky.social on Bluesky Find Tom at @tomanderson on Threads Join Tom's newsletter, Apple Talk, for more Apple coverage and tips & tricks. Tom has a new YouTube channel Show artwork by the great Randall Martin Design Enjoy Basic AF? Leave a review or rating! Review on Apple Podcasts Rate on Spotify Recommend in Overcast Intro Music: Psychokinetics - The Chosen Apple Music Spotify Transcripts and some images are AI generated and may contain errors and general silliness....

Do nagrania tego odcinka skłonił mnie poprzedni tydzień, wyrażenia w naszej technologicznej bańce i mail od Patrycji. Posłuchaj, dlaczego czasem warto wcisnąć hamulec. #BoCzemuNie ? POBIERZ ODCINEK Partnerzy technologiczni: > iDream – Apple Premium Reseller, Apple Premium Service Provider > Pancernik – Akcesoria do telefonów i nie tylko Linki: Zadaj pytanie w odcinku lub zgłoś temat! Newsletter podcastu Myślisz o podcaście? Sprawdź warsztat „Poznaj podcasting” Przedwczoraj Apple pokazał nowego MacBooka Air M5, więc wymieniłem baterię w starym M1 #301 – Daily journaling, czyli siła retrospekcji Papier nie przyjmie wszystkiego Post z telefonem HMD 1104G Bądźmy w kontakcie: X | Facebook | Instagram | kontakt@boczemunie.pl > Prowadzący: Krzysztof Kołacz Mam prośbę: Oceń ten podcast w Apple Podcasts oraz na Spotify i YouTube. Zostaw tyle gwiazdek, ile uznasz. Twoja opinia ma znaczenie! Zainteresowany współpracą? Pogadajmy. > Liczby znajdziesz na boczemunie.pl/partner/ Słuchaj, gdzie chcesz: YouTube | Apple Podcasts | Spotify | Overcast FM i przez RSS Dobrego odbioru! Bo czemu nie? Rozdziały: (00:00:00) PARTNERZY (00:00:01) INTRO (00:00:36) Wstępniak (00:03:19) Być sobą (00:25:02) Hygge, czyli oddech

(00:00) — Welcome and origin story: Kyle's path into med ed without being a physician(00:46) — Early admissions work and philosophy: get students into—and out of—med school(02:58) — What AACOM's VP of UME Services does: support across 71 DO locations(04:48) — Admitted-to-M1 is hard: student services and reps supporting the transition(05:12) — Time in the DO space: Marian start and osteopathic focus since 2018(06:38) — Biggest shift: single match and what's improved (and what hasn't)(10:07) — USMLE vs COMLEX: bias, requirements, and what applicants should weigh(12:33) — Data points: general surgery study, plus primary care ~55% context(16:51) — Advocacy update: the FAIR Act and reporting for federally funded programs(20:17) — The DO deposit debate: amounts, rationale, and potential changes(25:32) — Should you apply to DO schools? Choose by fit, curriculum, and support(31:01) — AACOMAS streamlining: 700-character experiences and tech to cut tedium(33:56) — Personal statements: copy/paste and when to add DO-specific experience(38:03) — Financial aid shift: Grad PLUS elimination and new student resources(40:19) — School-backed loans and lender partnerships: protecting students(43:40) — Final takeaways: faculty support, fit, and thriving as a DO or MDDr. Ryan Gray welcomes Kyle Hattenberg, AACOM's VP of Undergraduate Medical Education Services, for a practical look at DO admissions, advocacy, and student support. Kyle explains his new role supporting 71 osteopathic locations, including work on AACOMAS and student services to smooth the admitted-to-M1 transition. They unpack the single match era, persistent USMLE/COMLEX bias, and how AACOM is pushing for equal consideration—highlighting the FAIR Act, which would require federally funded programs to report on accepting and reviewing both DO and MD applicants.They tackle hot-button issues like nonrefundable deposits ($1,500–$3,000), why schools use them, and ongoing conversations about change—plus Kyle's advice to contact schools for hardship considerations. Kyle previews AACOMAS streamlining, including aligning the experience section to 700 characters and leveraging technology to reduce tedious data entry. He clarifies personal statement strategy and when DO-specific experiences belong. Finally, they address the elimination of the Grad PLUS loan, with AACOM building financial wellness resources, hiring dedicated support, and exploring partnerships, while noting that some schools already offer school-backed loans. The episode closes with guidance to choose schools based on fit, curriculum, and support—because thriving in medical school comes first.What You'll Learn:- How AACOM supports applicants and 71 osteopathic locations- What the single match means for DOs and where bias persists- FAIR Act goals and what programs may need to report- Upcoming AACOMAS tweaks, including 700-character activities- Deposit realities, Grad PLUS changes, and funding options

Ricky-Bobby and Dustin returns to talk GP's in portugal. Bulega fresh from WorldSBK joins GP as a fill-in rider for the gigantic alien shoes of MM93! Bez gets another W! Toprak gets to test the M1!Get signed up for your next TrackDaz event:http://trackdaz.trackrabbit.com**Want a deal on some boxo tools? Use the following link, and save 10% while also helping us get a bit of a commish! Its Win-Win!https://boxousa.com/TrackDazOr the code TrackDaz10*PIRELLI TIRES!! **You can get your Pirelli rubber from us directly on our registration site. Follow us on Facebook: / trackdaz Follow us on Instagram: @trackdazFollow the TrackDaz Crew:@chili144@jimmyz853@phen2210@gil823@formula_r@chili144@lgbrown_@dkm60@canea121@g_offsims@ricardo.abueg@trackdazkaren@fharo3@modbaez@m39023@dreek46@bubblesrides @r6_krissy_@shaunsummers62

Dave Ginsburg is joined by Mike Potter, Chuck Joiner, Marty Jencius, Jill McKinley, and Eric Bolden to break down a big week of Apple news. The panel discusses visionOS 26.4 beta updates, iOS 26.4 beta, the new iPhone 17e, M4 iPad Air, and refreshed MacBook Air and MacBook Pro models with M5 chips. The biggest debate centers around Apple's brand-new MacBook Neo, a $599 MacBook designed to compete with Chromebooks in education. Is it a smart gateway device for new users or an underpowered compromise? The panel shares strong opinions while also discussing Apple's strategy for expanding the Mac ecosystem. The show notes are at InTouchwithiOS.com  Direct Link to Audio  Links to our Show Give us a review on Apple Podcasts! CLICK HERE we would really appreciate it! Click this link Buy me a Coffee to support the show we would really appreciate it. intouchwithios.com/coffee  Another way to support the show is to become a Patreon member patreon.com/intouchwithios Website: In Touch With iOS YouTube Channel In Touch with iOS Magazine on Flipboard Facebook Page BlueSky Mastodon X Instagram Threads Summary In episode 411 of In Touch With iOS, host Dave Ginsburg is joined by Mike Potter, Chuck Joiner, Marty Jencius, Jill McKinley, and Eric Bolden to break down a week packed with Apple news, software updates, and new hardware announcements. The discussion begins with updates across Apple's platforms, including visionOS 26.4 beta 3, which appears to focus mainly on bug fixes and stability improvements as Apple prepares the platform for a future release. The panel shares their early impressions of the update process and discusses how developers are continuing to explore new possibilities around XR streaming and immersive experiences on Vision Pro. The group then moves into Apple's latest software updates, including iOS 26.3.1 and iOS 26.4 beta 3, along with updates for iPadOS, tvOS, and watchOS. While many of the updates are minor, Apple continues refining features such as Apple Music's Playlist Playground and preparing Apple Podcasts for native video podcast support. The panel also notes Apple's continued improvements to system security and stability while reminding listeners that beta software should still be used cautiously on primary devices. A major part of the episode focuses on Apple's latest hardware announcements. The panel begins with the iPhone 17e, Apple's new entry-level iPhone that includes the A19 chip, improved portrait photography, MagSafe support, and a 256GB base storage configuration while maintaining a competitive $599 starting price. The group discusses how this model could become the ideal recommendation for many users who want a reliable iPhone without paying for a higher-end Pro model. They also explore how the device could work well as a travel phone, a secondary phone, or a practical upgrade for family members who want simplicity and value. Next, the panel examines the newly refreshed iPad Air with the M4 chip, which now includes 12GB of RAM, Wi-Fi 7, and Apple's N1 wireless networking chip. The panel largely agrees that the iPad Air continues to be the "sweet spot" in Apple's tablet lineup, offering powerful performance without the premium cost of an iPad Pro. They discuss how the Air remains the most common recommendation for everyday users who want a capable iPad for productivity, media consumption, and general use. The conversation then shifts to the Mac side of Apple's announcements. Apple updated the Studio Display with Thunderbolt 5 support and upgraded internals, though the panel debates whether the premium pricing makes sense compared to other high-quality displays on the market. The discussion continues with Apple's updates to the MacBook Air with the M5 chip and the MacBook Pro with M5 Pro and M5 Max chips, which bring major performance gains, increased base storage, and improved graphics capabilities. Dave shares that he plans to upgrade his own MacBook Pro to an M5 Pro model, while the panel reflects on how dramatically Apple Silicon has improved Mac performance since the M1 era. The biggest debate of the episode centers around Apple's surprising announcement of the MacBook Neo, a brand-new entry-level MacBook starting at $599 and powered by an A18 Pro chip. Designed to compete directly with Chromebooks in education markets, the Neo introduces a new tier in Apple's laptop lineup. The panel dives into a lively discussion about whether the Neo represents a smart strategy to expand Apple's reach or a compromise that may struggle with longevity due to its limited memory and ports. Mike Potter delivers a passionate critique, arguing that the device feels like a disposable computer aimed primarily at schools, while other panelists see it as a secure, well-built, and affordable entry point for students, travelers, and users who need a simple Mac for basic tasks. The conversation also explores how the Neo might introduce a new generation of users to macOS while potentially competing with low-cost Windows laptops and Chromebooks. Some panelists see it as a gateway device that could lead users to upgrade to more powerful Macs later, while others question whether a refurbished MacBook Air might be a better long-term option. To close the show, Mike Potter shares updates on MacStock 10, including expanded programming, the addition of Ecamm's Creator Camp, and a new Saturday evening event that will be announced soon. The panel reflects on how MacStock continues to grow each year as an important gathering for Apple enthusiasts and creators. Topics and Links In Touch With Vision Pro this week.  BETA 26.4 beta 3 - 9.5 GB update but runs fast Mostly bug fixes and stability improvements Developers testing NVIDIA CloudXR support for streaming high-resolution XR content Focus on refining features added earlier in the 26.4 cycle rather than big UI changes.  Beta this week. iOS 26.4 Beta 3 was released this week Apple Releases iOS 26.3.1 and iPadOS 26.3.1 With Bug Fixes and Studio Display Support Apple Seeds Revised Third Betas of iOS 26.4 and iPadOS 26.4 to Developers, New Public Betas Apple Seeds Third Betas of iOS 26.4 and iPadOS 26.4 to Developers  Apple Releases Third watchOS 26.4, tvOS 26.4, and visionOS 26.4 Betas  Product Announcements This Week Apple's Biggest Week of 2026: Details on Every New Product Announced Apple Unveiled These Seven New Products This Week iPhone 17e Apple Announces iPhone 17e With A19 Chip, MagSafe, and More iPhone 17e Now Features 256GB Base Storage IPhone 16e vs. iPhone 17e Buyer's Guide: All Upgrades Compared  iPad Air M4 Apple Unveils iPad Air With M4 Chip, Increased RAM, Wi-Fi 7, and More First M4 iPad Air Benchmarks Surface M3 vs. M4 iPad Air Buyer's Guide: All Differences Compared - MacRumors Studio Display Apple's Two New Studio Display Models Feature Different A19 Chips New Studio Display and Studio Display XDR Will Have Day One Firmware Update Apple Updates Studio Display With Thunderbolt 5 and More Apple discontinues the Pro Display XDR Apple Discontinues Pro Display XDR and $999 Stand New Apple Studio Display and Studio Display XDR Don't Work With Intel Macs These Macs Can't Run the Studio Display XDR at 120Hz In Touch With Mac this week Apple Releases macOS Tahoe 26.3.1 With Support for Studio Display and Studio Display XDR Third macOS Tahoe 26.4 Beta Now Available for Developers Apple Removes 512GB Storage Option From M5 MacBook Pro, Drops SSD Upgrade Prices Macbook Neo macOS Will Alert You to MacBook Neo's USB-C Port Limitation MacBook Neo Features Two Different USB-C Ports 20+ MacBook Neo Compromises: What You Give Up for Apple's Cheapest Mac MacBook Neo Can Only Drive One External Display at 4K 60Hz MacBook Neo Starts at Just $499 for Students MacBook Neo Has Just 8GB RAM With No Upgrade Option Walmart will continue selling Macs after proving market for MacBook Neo Announcements Macstock X is here celebrating its 10th anniversary! With Three Full Days of expert-led Presentations and Workshops, Macstock's sessions are crammed full of productivity-enhancing content. NEW this year is a partnership with sponsor Ecamm. Ecamm Creator Camp: Mac Edition on July 9, 2026 there are only 100 tickets available for the bundle. There are 2 passes available: Macstock weekend pass July 10,11,12, 2026 or the Macstock Ecamm Bundle starting July 9 (only 100 tickets available)  Come join us. Register HERE Our Host Dave Ginsburg is an IT professional supporting Mac, iOS and Windows users and shares his wealth of knowledge of iPhone, iPad, Apple Watch, Apple TV and related technologies. Visit the YouTube channel https://youtube.com/intouchwithios follow him on Mastodon @daveg65, , BlueSky @daveg65  and the show @intouchwithios   Our Regular Contributors Jeff Gamet is a podcaster, technology blogger, artist, and author. Previously, he was The Mac Observer's managing editor, and Smile's TextExpander Evangelist. You can find him on Mastadon @jgamet Pixelfed @jgamet@pixelfed.social and Bluesky @jgamet.bsky.social‬ Podcasts The Context Machine Podcast  Retro Rewatch Retro Rewatch His YouTube channel https://youtube.com/jgamet Marty Jencius, Ph.D., is a professor of counselor education at Kent State University, where he researches, writes, and trains about using technology in teaching and mental health practice. His podcasts include Vision Pro Files, The Tech Savvy Professor and Circular Firing Squad Podcast. Find him at jencius@mastodon.social  https://thepodtalk.net  Eric Bolden is into macOS, plants, sci-fi, food, and is a rural internet supporter. You can connect with him by email at eabolden@mac.com, on Mastodon at @eabolden@techhub.social, on his blog, Trending At Work, and as co-host on The Vision ProFiles podcast.   Jill McKinley works in enterprise software, server administration, and IT A lifelong tech enthusiast, she started her career with Windows but is now an avid Apple fan. Beyond technology, she shares her insights on nature, faith, and personal growth through her podcasts—Buzz Blossom & Squeak, Start with Small Steps, and The Bible in Small Steps. Watch her content on YouTube at @startwithsmallsteps and follow her on X @schmern. Find all her work at http://jillfromthenorthwoods.com  Chuck Joiner is the host of MacVoices and hosts video podcasts with influential members of the Apple community. Make sure to visit macvoices.com and subscribe to his podcast. You can follow him on Twitter @chuckjoiner and join his MacVoices Facebook group. Guy Serle is one of the hosts of the new The Gmen Show along with GazMaz and email GMenshow@icloud.com  @MacParrot and @VertShark on X  Vertshark on YouTube, Google Voice +1 Area code  703-828-4677

Apple ha lanzado el MacBook Neo a 599 dólares con el chip A18 Pro y ya se ha montado el circo de siempre: que si chip de móvil, que si 8GB son una broma, que si el Geekbench sale igual que el M1 de 2020. En este episodio lo desmontamos todo con datos reales y contexto real. El A18 Pro no es "el chip del iPhone". Es Apple Silicon de cuarta generación, fabricado en el mismo proceso de 3nm que el M4, con la misma arquitectura ARMv9.2, ray tracing acelerado por hardware, 35 TOPS de Neural Engine —tres veces más que el M1— y memoria LPDDR5X. Todo eso en un portátil de 600 euros. En este episodio explicamos por qué el multi-core de Geekbench es el número equivocado para juzgar este equipo, cómo el A18 Pro supera al M1 en un 47% en single-core —que es lo que importa para el uso real de este Mac—, qué hace exactamente la gente con un portátil de este precio y para qué tipo de usuario está pensado el Neo, el Air M5 y el Pro M5.Ni fanboys ni haters: solo contexto técnico para entender lo que Apple ha hecho aquí y si tiene sentido para ti. Todo el contenido de Apple Coding Daily, junto con podcasts, vídeos, masterclasses y artículos, está disponible en la app Be Native (benative.dev). El desarrollo ha cambiado para siempre con la llegada de los agentes de IA, y para poder sacarle el mayor provecho y ser un desarrollador de los que buscan las empresas por su ultra-productividad, tienes que ser un Maestro: consígue la Maestría con el Swift Mastery Program 2026. Descárgala ya desde el App Store: Be Native y escúchanos desde ahí. Suscríbete a nuestro canal de Youtube: Apple Coding en YouTube Descubre nuestro canal de Twitch: Apple Coding en Twitch. Descubre nuestras ofertas para oyentes: - Cursos en Udemy (con código de oferta) - Apple Coding Academy - Suscríbete a Apple Coding en nuestro Patreon. - Canal de Telegram de Swift. Acceso al canal. --------------- Consigue las camisetas oficiales de Apple Coding con los logos de Swift y Apple Coding así como todo tipo de merchadising como tazas o fundas. - Tienda de merchandising de Apple Coding.

Prioritize Fun! What should you do with the time between getting accepted to medical school and orientation week? Fallon Jung, Anna Royer, Jonah Albrecht, and Charis Edwards tell their stories about finding out they got in (including one bathroom cry session and a Colorado NICU celebration), what they actually did to prepare, and why you absolutely shouldn’t pre-study. If you’re headed to medical school next year, this episode is basically your older sibling giving you the honest advice nobody else will—like why floor time in windowless study rooms is underrated, how to fill your cup before classes start, and the surprising truth about how much fun you can still have during M1 year. You’ll hear why these students think the admissions committee already believes you can do this, practical tips on setting up your study space without buying every resource known to humankind, and honest talk about mental health, sleep, and remembering why you wanted to be a doctor in the first place. The crew plus show photographer David Lee also debuts a med school edition of “That Escalated Quickly,” a party game that somehow involves electrocuting your brain’s pleasure centers, peppermint ice cream debates, and the very specific hell of planning to study instead of actually studying. Whether you’re pre-med, pre-PA, or just curious what actually happens before med school starts, hang out with your SCP friends who genuinely want you to succeed—and who aren’t afraid to laugh at themselves along the way. Episode credits: Producer: Anna Royer Co-hosts: Charis Edwards, Jonah Albrecht, Fallon Jung, David Lee The views and opinions expressed on this podcast belong solely to the individuals who share them. They do not represent the positions of the University of Iowa, the Carver College of Medicine, or the State of Iowa. All discussions are intended for entertainment purposes only and should not be taken as professional, legal, financial, or medical advice. Nothing said on this podcast should be used to diagnose, treat, or prevent any medical condition. Always seek qualified professional guidance for personal decisions. We Want to Hear From You: YOUR VOICE MATTERS! We welcome your feedback, listener questions, and shower thoughts. Do you agree or disagree with something we said today? Did you hear something really helpful? Can we answer a question for you? Are we delivering a podcast you want to keep listening to? Let us know at https://theshortcoat.com/tellus and we'll put your message in a future episode. Or email theshortcoats@gmail.com. We need to know more about you! https://surveys.blubrry.com/theshortcoat (email a screenshot of the confirmation screen to theshortcoats@gmail.com with your mailing address and Dave will mail you a thank you package!) The Short Coat Podcast is FeedSpot’s Top Iowa Student Podcast, and its Top Iowa Medical Podcast! Thanks for listening! We do more things on… Instagram: https://www.instagram.com/theshortcoat YouTube: https://www.youtube.com/theshortcoat You deserve to be happy and healthy. If you’re struggling with racism, harassment, hate, your mental health, or some other crisis, visit http://theshortcoat.com/help, and send additions to the resources there to theshortcoats@gmail.com. We love you.

Apple lo ha vuelto a hacer. Pero esta vez no ha sido un "más de lo mismo con mejor nota". El 3 de marzo de 2026 presentó los chips M5 Pro y M5 Max integrados en los nuevos MacBook Pro, y lo que hay dentro es el cambio de arquitectura más importante desde que llegó el M1. No hablamos de más núcleos ni de un proceso de fabricación más fino. Hablamos de repensar desde cero cómo se construye un chip. En este episodio desmontamos la Fusion Architecture pieza a pieza: qué es un die, por qué dividirlo en dos cambia las reglas del juego, qué implica para la disipación térmica, para la fabricación y para el futuro de Apple Silicon. Hablamos de los Neural Accelerators integrados en cada núcleo GPU, del aumento del ancho de banda del Neural Engine, de los 614 GB/s de memoria del M5 Max y de por qué eso importa más que los GHz cuando hablamos de inteligencia artificial en local. Y hacemos la comparativa con NVIDIA que todo el mundo hace pero casi nadie hace bien: CUDA vs MLX, H100 vs M5 Max, datacenter vs mochila. Sin banderas. Con números reales.

Ryan Dilks and Justin Peach react off the back of Middlesbrough's 3-1 win away at Birmingham.First win in 4 for Kim Hellberg's boys!Is that a corner turned for Boro?Are Birmingham's play-off hopes fading?Is it time running out for Chris Davies?Did George Michael fall out of his car on the M1?It's the Second Tier.Sign up to our Patreon here for ad-free episodes, bonus content and access to the Discord for $4 a month.You can also join our brand new YouTube Membership here!Watch this episode on YouTube here!Follow us on X, Instagram and email us secondtierpod@gmail.com.**Please rate and review us on Apple, Spotify or wherever you get your pods. It means a lot and makes it easy for other people to find us. Thank you!** Hosted on Acast. See acast.com/privacy for more information.

This week on The Broski Report, Fearless Leader Brittany Broski (finally) reacts to Heated Rival, reviews fidget toys, and discusses what's in her travel bag.ICE OUT OF OUR CITY / PROTEST RESOURCES:Script to Contact Your Representatives –  5calls.org ACLU – https://www.aclu.org/know-your-rights/protesters-rights Immigrant Defense Project – https://www.immigrantdefenseproject.org/raids-toolkit Freedom for Immigrants – https://www.freedomforimmigrants.org/resourcesImmigrants Legal Resource Center – https://www.ilrc.org/community-resources/know-your-rights Immigration Justice Campaign – https://immigrationjustice.us/ National Immigrant Justice Center – https://immigrantjustice.org/ MINNESOTA SPECIFIC RESOURCES:Stand With Minnesota Vetted Resource Hub – https://www.standwithminnesota.com/ MPLS Mutual Aid – https://linktr.ee/mplsmutualaid Immigrant Law Center of Minnesota – https://www.ilcm.org/ International Institute of Minnesota – https://iimn.org/ ICE OUT / Mutual Aid – https://linktr.ee/ICEOUTmutualaid  Watch The Broski Report AD FREE: https://patreon.com/broskireport The OFFICIAL Songs of The Week Playlist: https://open.spotify.com/playlist/3ULrcEqO2JafGZPeonyuje?si=061c5c0dd4664f01 

Unbox comfort at https://rovelab.com/Wanshow and check out their flash sale for a limited time. Sit back, relax, and enjoy M1. Visit https://www.squarespace.com/WAN and use offer code WAN for 10% off Go to http://factormeals.com/wan50off and use code wan50off to get 50% off your first Factor box PLUS free breakfast for 1 year Get a free 15-day trial of Odoo's all-in-one business solution and see how it can make your life easier! Check it out at https://www.odoo.com/wan Get a Circuit Board skin for your device so dbrand can keep messing with Linus at https://dbrand.com/pcb Check out the Razer Blade series of laptops; perfect for work or pleasure: https://lmg.gg/wanrazerblade The Razer Iskur V2 is on sale NOW, save 38% on a new gaming chair: https://lmg.gg/wanrazeriskur Get a special deal on Private Internet Access VPN today at https://www.piavpn.com/LinusWan Purchases made through some store links may provide some compensation to Linus Media Group. Learn more about your ad choices. Visit megaphone.fm/adchoices

Most brain decline, mood instability, and impulsive behavior start with a breakdown in how the brain's immune cells produce and use energy. This episode shows how mitochondrial health inside microglia influences cognition, emotion, and long-term brain resilience, and how everyday inputs quietly push those systems toward damage or repair. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, metabolism, and brain health. A Fellow of the American College of Nutrition and member of the Editorial Board of the Journal of Alzheimer's Disease, Dr. Perlmutter brings decades of clinical and research experience to this conversation on how inflammation and mitochondrial function shape the brain across the lifespan. Together, they explore how microglial cells shift their behavior based on metabolic conditions, and how those shifts influence neurodegeneration, emotional regulation, impulse control, and cognitive performance. The discussion covers real-world inputs that shape these systems, including sleep optimization, fasting, ketosis, glucose regulation, gut signaling, environmental toxins, and tools referenced in the episode such as red and infrared light, 40 Hz light and sound, hyperbaric oxygen, lithium, nicotine, supplements, nootropics, GLP-1 agonists, and dietary approaches like carnivore and ketosis. The conversation connects brain biology to lived experience, showing how metabolism influences behavior, decision making, and long-term human performance through a Smarter Not Harder lens. You'll Learn: • How microglia shift between supportive and destructive states and why metabolism drives that change • How mitochondrial function inside immune cells influences inflammation and brain resilience • How inflammation affects the prefrontal cortex, impulse control, and reward-driven behavior • What the episode says about GLP-1 agonists and behavior changes like reduced cravings and gambling • How gut-derived signaling and short-chain fatty acid balance (butyrate vs propionate) relates to brain function • How tools like red and infrared light, hyperbaric oxygen, and 40 Hz light and sound connect to microglia • The lifestyle levers discussed in the episode: sleep optimization, fasting, ketosis, glucose control, and toxin reduction • The compounds mentioned, including lithium, nicotine, urolithin A, CoQ10, rosmarinic acid, and dihydromyricetin Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: microglia brain health, brain immune system mitochondria, neuroinflammation podcast, mitochondrial dysfunction brain, david perlmutter podcast, dr david perlmutterneurologist, grain brain author podcast, alzheimers brain metabolism, parkinsons microglia, autism brain inflammation, gut brain immune signaling, short chain fatty acids brain, butyrate propionate brain, glp-1 brain behavior, glp-1 addiction research, red light therapy brain, infrared light mitochondria brain, 40 hz light sound brain, hyperbaric oxygen brain health, lithium microglia brain Resources: • Learn More About Dr. Perlmutter at: https://drperlmutter.com/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 - Introduction 1:45 - Autism Spectrum 4:38 - Alzheimer's & Beta Amyloid 7:02 - Brain Immune Cells 8:06 - GLP-1 & Parkinson's 10:44 - M1 vs M2 Microglia 13:08 - Pharmaceutical Microdosing 15:51 - Gene Therapy 19:09 - Mold & Toxins 21:58 - Environmental Pollution 26:05 - MPTP Discovery 29:07 - Healing Interventions 31:39 - Light & Sound Therapy 36:35 - Mitochondrial Function 44:57 - Inflammation & Prefrontal Cortex 48:00 - GLP-1 Global Impact 52:11 - Mitochondrial Community 56:05 - Consciousness & The Field 1:00:00 - Psychedelics 1:01:59 - Love & Judgment 1:06:35 - Death & Knowing 1:09:06 - Heart-Brain Connection 1:11:06 - Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.