Podcasts about pyramidal

Welcome to The Wild Card Podcast!  This is episode 294 of our attempt at this whole podcasting thing!! Today's episode features: Jared Eaton building a zoo, Jeff Curtis not caring enough, and Ron Blair singing the 80's hits!! Throughout the episode, you'll hear the three of us discuss such varied topics as: the way this podcast is about Class, a Sponsored Commercial, our favorite board game themes, the majesty of Monk, when your personalities argue, going full Family Feud, and occasionally we part from our tangents to build a Pyramid of Stupid! This week, Ron takes the guys through such challenging questions as our favorite soda flavors, animals, performances by the other guys, and so much more!!!  Thank you for joining us on this journey to wherever and we're sure that you'll never feel........too stupid as you listen to our Pyramidal podcast!Please like/subscribe and leave comments below! Let us know your thoughts on any of our Favorites pyramid questions, your favorite performances by your favorite Wild Cards, your favorite board games/board game themes, if you got to see The Producers at HCP, positivity chains (encourage one another!), any future reports you'd like us to do, and if you are interested in being an official Deckhead!P.S.  “Man fears time, yet time fears the pyramids.”~ Arab ProverbP.P.S. Stay Safe, Stay Wild, and Bite the Edge!

Today we start with why 70.3's are gaining popularity and roll that into training with more intensity. We look at how to explore higher zones and how to work that into your overall training. We talk about why it's important to remind yourself what it feels like and why you have to train it to truly know it. We get into why it can be more stressful to train alone and why it's important to swim, bike, and run with people faster than you. We talk about racing as a compass and look at how to test the boundaries and flirt with slightly unnerving workouts. Topics: 70.3's gaining popularity Underestimating your race 70.3's as training for your full There's a lot of different ways to stimulate Using racing as a compass Training to discomfort Testing boundaries Legs can't keep up If you don't train it you don't know it The importance of understanding ALL the zones In all disciplines Pyramidal training Polarized Remind yourself what it feels like Understanding All Out The top of the range The mental fatigue of hard sessions Training with faster people Applying race numbers to training? Outside vs. inside effort Group riding Higher stress when by yourself? Find slightly unnerving     Mike Tarrolly - mike@c26triathlon.com Robbie Bruce - robbie@c26triathlon.com

Check out my Tronic Radio on your favorite streaming platforms here: https://ssyncc.com/tronic-podcast Make sure to check out Pyramidal Decode's latest remix out now on Tronic: https://www.submithub.com/link/tr515 TBC This show is syndicated & distributed exclusively by Syndicast. If you are a radio station interested in airing the show or would like to distribute your podcast / radio show please register here: https://syndicast.co.uk/distribution/registration

Pour la semaine de Noël, 6 mini-épisodes, 6 pépites sur 6 espèces étonnantes, le plus souvent inconnues, emblématiques d'un milieu particulier, qui ont chacune - et chacun - besoin d'être protégées. Pourquoi et comment ? Écouter la réponse est déjà un premier pas.Dans cet épisode, l'Orchis pyramidal, une orchidée terrestre qui fait des 160 espèces d'orchidées terrestres poussant en France. Il existe 30 000 espèces d'orchidées connues, 95% sont épiphytes et vivent posées sur une autre plante, souvent un arbre. C'est la plus nombreuse famille de plante sur terre. Le mot "orchidée" vient d'uen racine grecque signifiant testicule, pourquoi ?Joyeux Noël… à nos frères et sœurs du Vivant !_______

Effizient schneller und besser werden? Mit Abwechslung im Training klappt's! Die Frage ist nur, wie man das genau angeht und wie sich das Training am besten gestalten lässt. In dieser Folge stellen wir zwei Methoden vor, die genau das zum Ziel haben: polarisiertes und pyramidales Training. Was diese beiden Ansätze ausmacht und welcher erfolgsversprechender ist, erfährst du hier.Foto: AdobeStock/standretMusik: No ExcusesChristmas-Aktion bei SHOKZ: Jetzt 30% sparen!--> 10 EUR Rabatt mit unserem Code "ACHILLES10"Hier findet ihr unsere aktuellen Gewinnspiele & Rabatt-Aktionen!Ihr wollt mehr? Dann klickt hier!Abonniert außerdem unseren Newsletter, um keine Podcastfolgen, Aktionen und Gewinnspiele mehr zu verpassen! Hosted on Acast. See acast.com/privacy for more information.

Effizient schneller und besser werden? Mit Abwechslung im Training klappts! Die Frage ist nur, wie man das genau angeht und wie sich das Training am besten gestalten lässt. In dieser Folge stellen wir zwei Methoden vor, die genau das zum Ziel haben: polarisiertes und pyramidales Training. Was diese beiden Ansätze ausmacht und welcher erfolgsversprechender ist, erfährst du hier.Foto: AdobeStock/standretMusik: No ExcusesChristmas-Aktion bei SHOKZ: Jetzt 30% sparen!--> 10 EUR Rabatt mit unserem Code "ACHILLES10"Hier findet ihr unsere aktuellen Gewinnspiele & Rabatt-Aktionen!Ihr wollt mehr? Dann klickt hier!Abonniert außerdem unseren Newsletter, um keine Podcastfolgen, Aktionen und Gewinnspiele mehr zu verpassen! Hosted on Acast. See ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

Effizient schneller und besser werden? Mit Abwechslung im Training klappts! Die Frage ist nur, wie man das genau angeht und wie sich das Training am besten gestalten lässt. In dieser Folge stellen wir zwei Methoden vor, die genau das zum Ziel haben: polarisiertes und pyramidales Training. Was diese beiden Ansätze ausmacht und welcher erfolgsversprechender ist, erfährst du hier.Foto: AdobeStock/standretMusik: No ExcusesChristmas-Aktion bei SHOKZ: Jetzt 30% sparen!--> 10 EUR Rabatt mit unserem Code "ACHILLES10"Hier findet ihr unsere aktuellen Gewinnspiele & Rabatt-Aktionen!Ihr wollt mehr? Dann klickt hier!Abonniert außerdem unseren Newsletter, um keine Podcastfolgen, Aktionen und Gewinnspiele mehr zu verpassen! Hosted on Acast. See ...Du möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude.Gern unterstützen wir dich bei deiner Podcast-Produktion.

New research suggests that the clustering of pyramids along the western desert margin of the Nile floodplain indicates that the area may once have been served by a large watercourse capable of supporting ambitious construction projects. Radar indicates the presence of a dried-up riverbed snaking through 62 miles of desert, likely for agricultural reasons. Historian Herodotus likewise documents the usage of Nile water in the importance of Pyramidal functions. Far away in Indonesia, research is also indicating that Gunung Padang is actually a 27,000 year old pyramid, dating extensively older than the Djoser pyramid in Egypt. Author Steven Myers joins us to discuss his work on the pyramid water pump theory: (http://www.thepump.org/)-FULL ARCHIVE & RSS: https://www.spreaker.com/show/the-secret-teachings Twitter: https://twitter.com/TST___Radio Facebook: https://www.facebook.com/thesecretteachings WEBSITE (BOOKS, RESUBSCRIBE for early & ad-free show access): http://thesecretteachings.info Paypal: rdgable@yahoo.com CashApp: $rdgable EMAIL: rdgable@yahoo.com / TSTRadio@protonmail.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-secret-teachings-with-ryan-gable--5328407/support.

Cette semaine, c'est un deep dive de geek comme on les aime. On reçoit Félix-Antoine Lapointe pour avoir sa perspective sur la différence entre la méthode d'entraînement polarisé et la méthode pyramidale.  Le Coin de Geek avec Charles Castonguay reviendra avec une plus grande fréquence à travers les épisodes plus traditionnaux du Upika Podcast. On fera des deep-dive avec ou sans invités sur des sujets très précis. Abonnez-vous, il y aura beaucoup de contenu à venir! «Upikapodcast» pour 10% de rabais sur votre première commande au https://upika.ca/ Pour suivre Charles: https://www.instagram.com/cast_charles/?hl=enPour nous suivre:https://www.instagram.com/upikasports/?hl=enhttps://www.instagram.com/upikapodcast/

Top Crew Academy is a coaching service run by Sam Dutney. He explains the differences and how they apply to masters rowing. Timestamps Different modes of training methodology are polarised and pyramidal. Most of the time people use pyramidal so the training intensity distribution is like a pyramid. It has a large base of low intensity, a moderate amount of mid intensity and a small amount of high intensity. Polarised training skips the mid intensity and has 20% at high intensity. 02:00 Percentages are 60: 30: 10% for pyramidal. Rowing training has been pyramidal for a long time - since 1930s. Polarised became popular in mid 2000s and is based on a study done on elite cyclists in endurance sports. 04:45 is HIIT influencing this change? The benefits of polarised training link well to the benefits of High Intensity Interval Training. What drives the benefits are the high intensity training - the top levels are very similar - the top level training is at or near top efforts. A huge amount of rowing performance comes from efficiency and time in the boat. Develop the skill in a polarised model in the low intensity sessions. 07:00 How to choose which mode is right for you Available time - if you can only train 3 times a week. Do a program with one low intensity and the other two as high intensity/ If doing 4-5 sessions a polarised model may be more suitable. Pyramidal training is effective in the early season and head racing. because you aren't trying to operate at maximum intensity. So pyramidal can be effective at this time of year. A 2016 paper on runners compared pyramidal and polarised training for 16 weeks; The results from pyramidal for 8 weeks and then shifting into polarised for 8 weeks was very much more effective than all the others. The polarised hard sessions have to be really hard and the easy sessions need to be really easy. As we get older you don't recovery as well that's where polarised training can help recovery for masters. Want easy live streams like this? Instant broadcasts to Facebook, YouTube, LinkedIn. Faster Masters uses StreamYard: https://streamyard.com/pal/d/5694205242376192

Sur les réseaux sociaux pullulent des influenceurs qui tentent de vous attirer vers des investissements douteux. Des formations de trading en ligne, des investissements dans des actions ou de la cryptomonnaie tout y passe. Méfiez-vous car il s'agit souvent d'arnaques pyramidales. Un système où la victime paye son adhésion et est chargée de trouver des nouvelles recrues. Cette stratégie ne fait rentrer de l'argent que lorsque le nombre de recrues augmente, car la source de revenus principale c'est justement cette adhésion. Que sont les ventes pyramidales ? Quel est le lien avec le système MLM ? Qu'est-ce qu'une pyramide de Ponzi ? Écoutez la suite de cet épisode de "Maintenant vous savez". Un podcast Bababam Originals, écrit et réalisé par Hugo de l'Estrac. À écouter aussi : Qu'est-ce que la procrastination ? Qu'est-ce que la méthode AAA, qui peut vous sauver au travail ? Quels sont les 3 conseils pour améliorer sa posture au bureau ? Retrouvez tous les épisodes de "Maintenant vous savez". Suivez Bababam sur Instagram. Learn more about your ad choices. Visit megaphone.fm/adchoices

BEST OF: New research suggests that the clustering of pyramids along the western desert margin of the Nile floodplain indicates that the area may once have been served by a large watercourse capable of supporting ambitious construction projects. Radar indicates the presence of a dried-up riverbed snaking through 62 miles of desert, likely for agricultural reasons. Historian Herodotus likewise documents the usage of Nile water in the importance of Pyramidal functions. Far away in Indonesia, research is also indicating that Gunung Padang is actually a 27,000 year old pyramid, dating extensively older than the Djoser pyramid in Egypt. Author Steven Myers joins us to discuss his work on the pyramid water pump theory: (http://www.thepump.org/)

I read from extra point to extravagant.     "The pyramidal tracts are named because they pass through the pyramids of the medulla oblongata" and the "extrapyramidal system" controls posture and muscle tone (things that are involuntary). https://en.wikipedia.org/wiki/Pyramidal_tracts https://en.wikipedia.org/wiki/Extrapyramidal_system     Extratropical Cyclones form around 30° to 60° away from the equator.  https://en.wikipedia.org/wiki/Extratropical_cyclone     Unfortunately, the fetus is unable to survive in an extrauterine (ectopic) pregnancy, except in very rare exceptions.  https://en.wikipedia.org/wiki/Ectopic_pregnancy     Here's the etymology for "extravagant". https://www.etymonline.com/word/extravagant#etymonline_v_14130     The word of the episode is "extrasensory perception".     Theme music from Jonah Kraut https://jonahkraut.bandcamp.com/     Merchandising! https://www.teepublic.com/user/spejampar     "The Dictionary - Letter A" on YouTube   "The Dictionary - Letter B" on YouTube   "The Dictionary - Letter C" on YouTube   "The Dictionary - Letter D" on YouTube   "The Dictionary - Letter E" on YouTube     Featured in a Top 10 Dictionary Podcasts list! https://blog.feedspot.com/dictionary_podcasts/     Backwards Talking on YouTube: https://www.youtube.com/playlist?list=PLmIujMwEDbgZUexyR90jaTEEVmAYcCzuq     https://linktr.ee/spejampar dictionarypod@gmail.com https://www.facebook.com/thedictionarypod/ https://www.threads.net/@dictionarypod https://twitter.com/dictionarypod https://www.instagram.com/dictionarypod/ https://www.patreon.com/spejampar https://www.tiktok.com/@spejampar 917-727-5757

Welcome to The KSL Greenhouse Show! Join hosts Maria Shilaos and Taun Beddes as they talk all things plants, tackle your toughest gardening questions, and offer tips that can help you maintain a beautiful yard. Listen every Saturday from 8am to 11am at 102.7 FM, 1160 AM, kslnewsradio.com, or on the KSL NewsRadio App. Follow us on Facebook and Instagram at @kslgreenhouse. Happy planting! #KSLGreenhouse    Guest: Brian Lloyd with Olson’s Greenhouse    9:05  Feature: How to Successfully Put Together a Container Garden  9:20  What varieties of columnar crabapples and Rose of Sharons are best for a space that’s 4 to 6 feet wide? Does the new formula for Roundup work well, or is it better to use a product with glyphosate in it? Is there anything I can plant or spray on my shrubs to prevent my dog from urinating on them?  9:35  Am I supposed to cut off all the dead internal branches of my Pyramidal Hornbeam? What are the pros and cons of painting the trunks of my peach trees or wrapping them in burlap? What do I do every year to reduce weeds in my yard?  9:50  Should I be worried about my park strip maple trees turning yellow? Where can I find Joshua trees? What do I do if earthworms caused my back lawn to be bumpy? 

// SHARE AND RATE THE PODCAST! iTunes: https://trainerroad.cc/apple2  Spotify: https://trainerroad.cc/spotify2  Google Podcasts: https://trainerroad.cc/google // TOPICS COVERED (0:00:00) Welcome! (0:01:13) Increased Training Load and overreaching (0:17:41) 16wk Pyramidal Training with average cyclists (0:42:18) Giro's CRAZY new TT helmet (0:47:23) Pro Cyclist Energy Availability during Spring Classics (1:05:16) TdF Route data from a 58yo cyclist // RESOURCES MENTIONED - Why You ACTUALLY Need a Recovery Shake (and What SHOULD Be in it) https://youtu.be/bR2y3Q2a2qA  - Science-Backed Nutrition Strategy for Cyclists https://youtu.be/z2HXE1-il_Q  - How to Lose Weight and Keep it Off with Dr. Kyle Pfaffenbach  – Ask a Cycling Coach Podcast 463 https://youtu.be/563mWgqvMZc  - Decreased energy availability during training overload is associated with non-functional overreaching and suppressed ovarian function in female runners, Schaal, et al,. 2021 https://trainerroad.cc/schaal2021  - Effects of a 16-Week Training Program with a Pyramidal Intensity Distribution on Recreational Male Cyclists https://trainerroad.cc/magalhaes2024  - Giro's new TT helmet: https://escapecollective.com/there-are-no-words/  - Alternate-Day Low Energy Availability During Spring Classics in Professional Cyclists https://trainerroad.cc/heikura2019  - The Tour de France, also possible for mortals? A comparison of a recreational and a World Tour cyclist  https://trainerroad.cc/barrancogil2024  // TRY TRAINERROAD RISK FREE FOR 30 DAYS! https://trainerroad.cc/GetFaster TrainerRoad is the #1 cycling training app. No other cycling app is more effective. Over 17,000 positive reviews, a 4.9 star App Store rating. // HELPFUL LINKS - Have a question for the podcast? Ask here: https://trainerroad.cc/3HTFXNi - Watch our latest Cycling Science Explained video now! https://youtu.be/z2HXE1-il_Q  - TrainerRoad on Instagram: https://www.instagram.com/trainerroad/ - TrainerRoad Forum: https://trainerroad.cc/3uHvLnE - TrainerRoad on Strava: https://www.strava.com/clubs/trainerroad - TrainerRoad on Facebook: https://www.facebook.com/TrainerRd - TrainerRoad on X: https://www.x.com/TrainerRoad  - Learn more about TrainerRoad: https://trainerroad.cc/3LBb5Ur - Learn more about Adaptive Training: https://trainerroad.cc/35Tqtea  - Listen to the Successful Athletes Podcast: https://trainerroad.cc/3JmKrN5 - Listen to the Science of Getting Faster Podcast: https://trainerroad.cc/3LpuIhP - Training Blog: https://trainerroad.cc/3gCdNdN

Two identical triathletes take on a training program. The first does mostly easy training with some high-intensity sessions. The other does mostly easy training with threshold workouts and minimal high-intensity sessions. Who comes out on top? That's the question we aim to answer today. The two examples provided are polarised and pyramidal training models. And there's a huge debate about which approach is superior. As always, this episode is brought to you by our proud sponsor Giant Australia. For all your bike, training, and racing needs, ride life, ride Giant. Timestamp:00:00 - Introduction00:55 - Gratitude04:15 - Polarised vs Pyramidal15:30 - The Method To Use23:10 - Scientific Testing30:30 - Athlete Requirements Vs Scientific Studies32:00 - Different Approaches to Training36:00 - It's Never One Thing42:30 - Beginner and Intensity46:50 - Low Stress Vs High Stress If you want to learn how to TRAIN SMARTER and RACE FASTER, you can join our weekly coaching email, just go to: getfastpodcast.com Some of you might already be in there, but many of you won't be and so this is our official invitation for you to come and join our free community: www.facebook.com/groups/trivelocoaching Check us out on Instagram: https://www.instagram.com/trivelocoaching/ Disclaimer: The Content in this podcast is in no way intended to be medical advice, treatment or diagnoses. None of our Content is intended to imply that any products mentioned, remedies or information provided are intended to prevent, diagnose, cure or alleviate a disease, ailment, defect or injury or should be used for therapeutic purposes. The Content is intended to assist you with running, cycling, swimming or triathlon and should not be substituted for medical advice by your healthcare professional. We do not accept any liability for any injury, loss, or damage incurred by the use or reliance on our Content.See omnystudio.com/listener for privacy information.

BEST OF TST: New research suggests that the clustering of pyramids along the western desert margin of the Nile floodplain indicates that the area may once have been served by a large watercourse capable of supporting ambitious construction projects. Radar indicates the presence of a dried-up riverbed snaking through 62 miles of desert, likely for agricultural reasons. Historian Herodotus likewise documents the usage of Nile water in the importance of Pyramidal functions. Far away in Indonesia, research is also indicating that Gunung Padang is actually a 27,000 year old pyramid, dating extensively older than the Djoser pyramid in Egypt. Author Steven Myers joins us to discuss his work on the pyramid water pump theory: (http://www.thepump.org/)

This week's episode is a deep dive into training, David and Olav go into the details of the training process. This follows on from the fundamentals of the Norwegian system, planning and racing. (00:00) Introduction (00:51) How Should you Apportion Training Time?  (03:50) How Should an Age Groupers with Balanced Disciplines of the Triathlon Apportion Training Volume in a Week? (09:57) How do you Decide Whether to Work on Your Strengths or Weaknesses? (17:50) Volume is Multidimensional  (21:25) Power Law (24:18) How do you Apportion Intensity and Volume Between Disciplines?  (26:00) The Problem with Training Zones  (28:33) Pyramidal vs Polarized Models (33:15) Differences Between Professionals and Age Groupers in Training Intensity Distribution  (33:51) Double Threshold Training (36:14) Distributing Volume and Intensity in a Week (46:12) How to Adjust Training When not Recovering  (50:05) RPE and lack of a second dimension in it  (61:46) Intensity Control (65:40) Intensity Control in Swimming  (68:55) Key, Development and Maintenance Sessions  (82:54) How do we Build a Microcycle?  VO2Master To benefit from our unique offer for a Free Assessment Kit with the purchase of an Analyzer Kit from VO2 Master, head to www.vo2master.com and enter code: OLAVMETHOD during checkout (Available for Online Orders Only). Discount valid from January 4, 2024 – March 31, 2024 only.  Find VO2Master at: www.vo2master.com On Instagram, Facebook, Twitter/X and YouTube all @VO2master On LinkedIn @ vo2-master Maurten To benefit from the discount code and get 20% off the Maurten 1/52 Collection, simply add the 1/52 Collection to your basket at Maurten.com and enter code TheNorwegianMethod at the checkout. Note the code can only be used twice per customer. Find Maurten at: Website - www.maurten.com Instagram - @maurten_official YouTube - Maurten Official - YouTube Plasmaide To try Plasmaide go to the Plasmaide website and use code NMP25 for a 25% discount on Plasmaide products. Find plasmaide at:  www.plasmaide.co.uk and www.plasmaide.com.au  @plasmaide on Instagram, Plasmaide on LinkedIn and Facebook Graphic Design by Georgia Humphreys Introduction by Santara Studios Produced and Edited by David Lipman

Far too many of us get caught up in the details of training. 80/20. Polarized. Pyramidal. VO2. Tempo. These topics are great and really worth analyzing, but it's far from the most important part. ----- Links: ⁠⁠Video⁠⁠ ----- Want to be able to ask your own questions for this podcast? Head to the Trail and Ultra Running Nutrition group on FB:⁠⁠⁠⁠⁠https://www.facebook.com/groups/trailultratraining⁠⁠⁠⁠⁠ Thank you for listening! --- Send in a voice message: https://podcasters.spotify.com/pod/show/trailultratraining/message Support this podcast: https://podcasters.spotify.com/pod/show/trailultratraining/support

New research suggests that the clustering of pyramids along the western desert margin of the Nile floodplain indicates that the area may once have been served by a large watercourse capable of supporting ambitious construction projects. Radar indicates the presence of a dried-up riverbed snaking through 62 miles of desert, likely for agricultural reasons. Historian Herodotus likewise documents the usage of Nile water in the importance of Pyramidal functions. Far away in Indonesia, research is also indicating that Gunung Padang is actually a 27,000 year old pyramid, dating extensively older than the Djoser pyramid in Egypt. Author Steven Myers joins us to discuss his work on the pyramid water pump theory: (http://www.thepump.org/)This show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/5328407/advertisement

BashTech Radio 60 with ETHOS (IE) www.bashtechrecords.com Follow ETHOS (IE): https://soundcloud.com/ethosireland https://www.instagram.com/ethosireland https://linktr.ee/ethosireland Tracklist: IIrazu - Genesis ETHOS (IE) - UNRELEASED Notzing - Protae Kike Pravda - Reverberation CONCEPTUAL - The High Priestess VSK - Sfere a Contatto Lidvall & Pyramidal decode - Fundamental point Viels & Pyramidal Decode - Entropia Variabile CONCEPTUAL - Not An Easy One ETHOS(IE) - UNRELEASED ETHOS(IE) - UNRELEASED Lewis Fautzi - Tension Lewis Fautzi - 141021 NWHR - El Regreso Lakej - Cognitive Recall (Oliver Rosemann Remix) Spring Rolls - Une Texture Inverse Pyramidal Decode - Bliss

durée : 00:07:20 - Info médias - Dans le documentaire "Les Plages de l'embarquement", diffusé dans "Envoyé Spécial" sur France 2, le journaliste Julien Goudichaud montre les rouages mafieux du passage des candidats à l'exil par voie maritime vers le sol britannique.

Fábio Dominski (@fabiodominski) • Fotos e vídeos do Instagram Fonte: Enes, A., Oneda, G., Leonel, D. F., Ramos, R. A., Kvas-Cabral, V. C., Bernardo, M. F., ... & Souza-Junior, T. P. (2023). Drop-Set Resistance Training versus Pyramidal and Traditional Sets Elicits Greater Psychophysiological Responses in Men. Perceptual and Motor Skills, 00315125231176729. --- Support this podcast: https://podcasters.spotify.com/pod/show/fabiodominski/support

Artist: Pyramidal Decode Label: Immaterial.Archives Title: Indefinite Reason CAT: IA021 Format: Digital Release Date: 19.05.2023 TRACKLIST: 01. Subterranean 02. Contorsione 03. Alterazione 04. Feelings 05. Solitudine Buy the EP here: Bandcamp: https://immaterialarchives.bandcamp.com/album/ia021-indefinite-reason Follow IMMATERIAL.ARCHIVES here: Facebook: https://www.facebook.com/Immaterial.Archives/ Instagram: https://www.instagram.com/immaterial.arc/ Soundcloud: https://soundcloud.com/immaterialarchives Follow PYRAMIDAL DECODE here: Facebook: https://www.facebook.com/PyramidalDecode Instagram: https://www.facebook.com/pyramidal_decode Soundcloud: https://soundcloud.com/pyramidal-track

TECH CLUBBERS PODCAST W/ PYRAMIDAL DECODE Born and raised in Italy since '98, Pyramidal Decode is the pseudonym of a techno polyhedral producer. He started DJing as a young teenager and has recently released some outstanding projects in labels such as Modularz, Edit Select, Dead Cert. Records, Warm Up Recordings, MORD, Immaterial Archives and Axis. Follow PYRAMIDAL DECODE here: Facebook: https://www.facebook.com/PyramidalDecode Instagram: https://www.instagram.com/pyramidal_decode Soundcloud: https://soundcloud.com/pyramidal-track

Dr Glenn McConell chats with Professor Stephen Seiler from the University of Agder in Norway. He is American who started his career in USA before moving to Norway almost 30 years ago. He points out that most exercise training research is based around university semesters with mainly untrained to trained transitions which is very different to what athletes do. Stephen coined the term polarized training in 2004 and makes the argument that this is the best way to train and that most world class endurance athletes train this way. This discussion is interesting to compare and contrast with recent episodes with A/Prof Andrew Coggan and Prof Michael Joyner who tend to say all roads lead to Rome. Twitter: @StephenSeiler 0:00. Introduction and welcome 2:09. Stephen's excellent sports science website from back in 1995/6 4:30. How Stephen got into exercise research 7:12. David Costill 8:23. Stephens early heart research in rats then move to Norway 11:37. His time at the University of Texas in Austin 13:50. Debates about the best ways to train for endurance 17:20. Ex training research is based around university semesters 21:45. Norway: “Threshold training to much pain due too little gain” 22:50. Stephen coined the term polarized training in 2004. 23:45. Most endurance athletes do most training below LT1 24:20. Three zone and five zone exercise training models 29:10. Pyramidal training 30:45. Sharpening/tapering before races (more polarized) 32:43. Exercise training: signal versus stress 39:30. Manipulating training frequency, duration and intensity 41:03.Overtraining: maximum heart rate (parasympathetic hypersensitivity) etc 48:13. People starting out,  get them out the door and develop habit 53:20. Zones as VO2 max goes up 55:35. How know zones?, lactate?, HR, power (Andy Coggan), RPE, talking test 59:33. Hilly running/intervals, metallic taste in mouth, coughing 1:02:50. Do swimmers do polarized training though? David Costill 1:05:02. Polarized training. Approx 80/20 based on sessions, 90/10 based on time 1:08:30. Black hole intensity. Not really easy and not really hard 1:10;46. Threshold training pace, Importance of duration (intensity x duration). HRV 1:17:12.  Agrees with Andy Coggans points that lactic acid does not inhibit fat oxidation 1:19:32. Zone 2 and Inigo San Milan 1:22:50. Mitochondrial biogenesis, AMPK and calcium. Intensity vs volume 1:27:48. Cardiovascular drift/ uncoupling 1:30:35. But don't most athletes do pyramidal training?    1:33:40. Race pace specificity 1:34:08. Isn't it logical that the larger the training volume the lower the average intensity? 1:38:40. Pro cyclists training averages only 65% of max HR 1:43:10. Lab evidence vs data from athletes Strava etc 1:44:25. Doing lots of threshold training causes stagnation/functional over reaching 1:48:06. Take the emotion / religion out re the importance of Zone 2. Importance of duration. 1:54:59. Outro (9 seconds) Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise's effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all. The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research. Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: glenn.mcconell@gmail.comSubscribe to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218 Not medical advice

In this episode of Run with Fitpage, we had the pleasure of hosting Dr. Luca Filipas, a researcher and coach with expertise in different training models - both - practical and theoretical. Vikas and Dr. Filipas discuss how periodization works along with his extensive research on the topic of the Pyramidal vs Polarised training model. Dr. Luca Filipas is an endurance coach and Sports Scientist with over a decade of experience working with both amateur and professional athletes. He has a wide-ranging academic background, having earned a bachelor's degree in Physical Education and Sports Science, a master's degree in Exercise Physiology, and a Ph.D. in Biomechanics and Motor Control. Dr. Filipas' passion for endurance sports began with running, and he has since worked with athletes in a variety of disciplines, including triathlon, cycling, and skiing.Dr. Filipas is known for his unique coaching approach, which blends the art and science of training to help his athletes achieve their goals. He is particularly interested in the pyramidal and polarized training models and has conducted research on the effects of each on endurance performance. His study found that both models can be effective, but that the pyramidal model may be better suited for certain types of athletes. Dr. Filipas' coaching methodology is based on a thorough understanding of the individual athlete's needs, and he uses a variety of tools to help his athletes optimize their performance, including periodization, intensity measurement, and other techniques.Link to the research: Effects of 16 weeks of pyramidal and polarized training intensity distributions in well-trained endurance runnersKnow more about Dr. Filipas' works and coaching at lucafilipas.comAbout Vikas Singh:Vikas Singh, an MBA from Chicago Booth, worked at Goldman Sachs, Morgan Stanley, APGlobale, and Reliance before coming up with the idea of democratizing fitness knowledge and helping beginners get on a fitness journey. Vikas is an avid long-distance runner, building fitpage to help people learn, train, and move better.For more information on Vikas, or to leave any feedback and requests, you can reach out to him via the channels below:Instagram: @vikas_singhhLinkedIn: Vikas SinghGmail: vikas@fitpage.inTwitter: @vikashsingh1010Subscribe To Our Newsletter For Weekly Nuggets of Knowledge!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.25.538286v1?rss=1 Authors: Taxidis, J., Madruga, B., Melin, M. D., Lin, M., Golshani, P. Abstract: Hippocampal spiking sequences encode and link behavioral information across time. How inhibition sculpts these sequences remains unknown. We performed longitudinal voltage imaging of CA1 parvalbumin- and somatostatin- expressing interneurons in mice during an odor-cued working memory task, before and after training. During this task, pyramidal odor-specific sequences encode the cue throughout a delay period. In contrast, most interneurons encoded odor delivery, but not odor identity, nor delay time. Population inhibition was stable across days, with constant field turnover, though some cells retained odor-responses for days. At odor onset, a brief, synchronous burst of parvalbumin cells was followed by widespread membrane hyperpolarization and then rebound theta-paced spiking, synchronized across cells. Two-photon calcium imaging revealed that most pyramidal cells were suppressed throughout the odor. Positive pyramidal odor-responses coincided with interneuronal rebound spiking; otherwise, they had weak odor-selectivity. Therefore, inhibition increases the signal-to-noise ratio of cue representations, which is crucial for entraining downstream targets. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.18.537149v1?rss=1 Authors: Saghafi, S., Rumbell, T. H., Gurev, V., Kozloski, J. C., Tamagnini, F., Wedgwood, K. C., Diekman, C. O. Abstract: Alzheimer's disease (AD) is believed to occur when abnormal amounts of the proteins amyloid beta and tau aggregate in the brain, resulting in a progressive loss of neuronal function. Hippocampal neurons in transgenic mice with amyloidopathy or tauopathy exhibit altered intrinsic excitability properties. We introduce a novel parameter inference technique, deep hybrid modeling (DeepHM), that combines deep learning with biophysical modeling to map experimental data recorded from hippocampal CA1 neurons in transgenic AD mice and age-matched wildtype littermate controls to the parameter space of a conductance-based CA1 model. Although mechanistic modeling and machine learning methods are by themselves powerful tools for approximating biological systems and making accurate predictions from data, when used in isolation these approaches suffer from distinct shortcomings: model and parameter uncertainty limit mechanistic modeling, whereas machine learning methods disregard the underlying biophysical mechanisms. DeepHM addresses these shortcomings by using conditional generative adversarial networks (cGANs) to provide an inverse mapping of data to mechanistic models that identifies the distributions of mechanistic modeling parameters coherent to the data. Here, we demonstrate that DeepHM accurately infers parameter distributions of the conductance-based model and outperforms a Markov chain Monte Carlo method on several test cases using synthetic data. We then use DeepHM to estimate parameter distributions corresponding to the experimental data and infer which ion channels are altered in the Alzheimer's mouse models compared to their wildtype controls at 12 and 24 months. We find that the conductances most disrupted by tauopathy, amyloidopathy, and aging are delayed rectifier potassium, transient sodium, and hyperpolarization-activated potassium, respectively. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.18.537377v1?rss=1 Authors: Xiao, K., Li, Y., Chitwood, R. A., Magee, J. C. Abstract: Behavioral timescale synaptic plasticity (BTSP) is a type of non-Hebbian synaptic plasticity reported to underlie place field formation in the hippocampal CA1 neurons. Despite this important function, the molecular mechanisms underlying BTSP are poorly understood. The Calcium-calmodulin-dependent protein kinase II (CaMKII) is activated by synaptic transmission-mediated calcium influx and its subsequent phosphorylation is central to synaptic plasticity. Because the activity of CaMKII is known to outlast the event triggering phosphorylation, we hypothesized it could be involved in the extended timescale of the BTSP process. To examine the role of CaMKII in BTSP, we performed whole-cell in-vivo and in-vitro recordings in CA1 pyramidal neurons from mice engineered to have a point mutation at the autophosphorylation site (T286A) causing accelerated signaling kinetics. Here we demonstrate a profound deficit in synaptic plasticity, strongly suggesting that CaMKII signaling is required for BTSP. This study elucidates part of the molecular mechanism of BTSP and provides insight into the function of CaMKII in place cell formation and ultimately learning and memory. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Nachdem wir in der letzten Ausgabe die Basics zur Trainingsintensitätsverteiung (TID) geklärt haben, widmen wir uns diesmal den richtig spannenden Fragen zur Evidenz: - Welche TID ist "die beste"? UND: - Was muss man dabei (noch) beachten? Den Rahmen dieser Episode bildet der "Schlagabtausch" zwischen zwei verschiedenen Arbeitsgruppen, die das für und wider polarisierten Trainings diskutieren. Wer am Ende die Oberhand behält und wie ihr die individuell "beste" TID findet, erfahrt ihr in dieser Folge. Link zum Videopodcast auf YouTube: https://youtube.com/playlist?list=PLGrWhjV7T1HabXM9m-UvepBHn36iFphEX 0:00:00 Intro 0:01:54 Recap zu den Basics 0:05:37 Welche TID ist optimal? 0:07:39 PRO polarisierte TID 0:08:39 Korrelationsanalysen 0:13:14 Meta-Analyse 0:18:28 Interventionsstudien 0:23:15 CONTRA polarisierte TID 0:25:08 pyramidale TIDs 0:28:34 fehlende Evidenz 0:37:10 Response von Foster et al. 0:45:56 Response von Burnley et al. 0:50:38 Was sollte man beachten? 1:02:20 alternative Konzepte 1:04:31 Konzentrationsprofile 1:06:53 Zusammenfassung 1:09:43 Outro Literatur: Bourgois et al. (2019). Int J Sports Physiol Perform: https://pubmed.ncbi.nlm.nih.gov/31484159/ Burnley et al. (2022). Med Sci Sports Exerc: https://pubmed.ncbi.nlm.nih.gov/35135998/ Burnley et al. (2022). Response to Forster et al.: https://pubmed.ncbi.nlm.nih.gov/35576139/ Casado et al. (2021). J Strength Cond Res: https://pubmed.ncbi.nlm.nih.gov/31045681/ Esteve-Lanao et al. (2007). J Strength Cond Res: https://pubmed.ncbi.nlm.nih.gov/17685689/ Filipas et al. (2022). Scand J Med Sci Sports: https://pubmed.ncbi.nlm.nih.gov/34792817/ Foster et al. (2022) Med Sci Sports Exerc: https://pubmed.ncbi.nlm.nih.gov/35136001/ Forster et al. (2022). Response to Burnley et al.: https://pubmed.ncbi.nlm.nih.gov/35576138/ Henritze et al. (1985). Eur J Appl Physiol: https://pubmed.ncbi.nlm.nih.gov/4018061/ Hydren & Cohen (2015). J Strength Cond Res: https://pubmed.ncbi.nlm.nih.gov/26595137/ Muñoz et al. (2014a). Int J Sports Physiol Perform: https://pubmed.ncbi.nlm.nih.gov/23921084/ Muñoz et al. (2014b). Int J Sports Physiol Perform: https://pubmed.ncbi.nlm.nih.gov/23752040/ Neal et al. (1985). J Appl Physiol:https://pubmed.ncbi.nlm.nih.gov/23264537/ Passfield & Hopker (2017). Int J Sports Physiol Perfrom: https://pubmed.ncbi.nlm.nih.gov/27967295/ Röhrken et al (2020). Front Physiol: https://pubmed.ncbi.nlm.nih.gov/33281607/ Rosenblat et al. (2019). J Strength Cond Res: https://pubmed.ncbi.nlm.nih.gov/29863593/ Seiler & Kjerland (2006). Sand J Med Sci Sports: https://pubmed.ncbi.nlm.nih.gov/16430681/ Sjödin et al. (1982). Eur J Appl Physiol: https://pubmed.ncbi.nlm.nih.gov/6213407/ Sperlich et al. (2022). Med Sci Sports Exerc: https://pubmed.ncbi.nlm.nih.gov/35704443/ Stöggl & Sperlich (2014). Front Physiol: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912323/ Stöggl & Sperlich (2019). Front Physiol: https://pubmed.ncbi.nlm.nih.gov/31178747/ Zinner et al. (2018). Med Sci Sports Exerc: https://pubmed.ncbi.nlm.nih.gov/29509644

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.15.536995v1?rss=1 Authors: Tarusawa, E., Hasegawa, S., Noda, D., Kawamura, N., Fukazawa, Y., Watanabe, M., Hirabayashi, T., Yagi, T. Abstract: Clustered protocadherins (cPcdhs) are candidates for the neural circuit formation; however, the localization of cPcdhs in pre- and post-synaptic compartments has not been well characterized. Here we examined the localization of cPcdh{gamma} proteins in the mouse hippocampal CA1 region using light and electron microscopy. From postnatal day 7 to 21, cPcdh{gamma} immunosignals were detected in approximately 40-60% of spines of pyramidal cells. SDS-digested freeze-fracture replica labelling revealed that cPcdh{gamma} immunolabeling was found in 50% of PSD 95-positive postsynaptic profiles but only in less than 10% of vGluT1-positive pre-synaptic terminals. Interestingly, cPcdh{gamma}-positive pre-synaptic terminal was exclusively accompanied by cPcdh{gamma}-positive postsynaptic counterpart. In addition, electrophysiological investigations revealed that the miniature excitatory postsynaptic current frequency in cPcdh{gamma} cKO mice was significantly higher than that in wild-type mice. These results suggest that cPcdh{gamma} proteins are unequally distributed in the pre- and post-synaptic membrane during neural circuit development and regulate the number of excitatory synapses. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.10.536291v1?rss=1 Authors: Patel, A. V., Nguyen, A., Paletta, P., Choleris, E., Bailey, C. D. C. Abstract: Pyramidal neurons located within layer V of the medial prefrontal cortex drive cognitive circuits by integrating afferent signals and sending efferent projections to cortical and subcortical targets. This role is supported by cholinergic neurotransmission, which modulates pyramidal neuron excitability via postsynaptic nicotinic receptors. We employed whole-cell electrophysiology with neuron reconstruction in brain slices from mice of both sexes to demonstrate that medial prefrontal layer V pyramidal neurons comprise three subtypes that have distinct electrophysiological properties, receptor isoform-specific nicotinic responses, and projection targets. Burst-firing neurons may be sub-divided into subtypes having (i) 7 isoform nicotinic responses and projections to the contralateral cortex, or (ii) 7 and {beta}2 isoform nicotinic responses and projections to the nucleus accumbens. Regular-firing neurons have {beta}2 isoform nicotinic responses and projections to the ventromedial thalamus. These findings provide new insight into an isoform-specific mechanism by which cholinergic neurotransmission modulates distinct efferent projections from this cognitive brain region. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

This week's episode of The Sunday Shakeout features an informative guide to a heavy topic - training intensity distribution, or TID. Your TID could make or break your training depending on how you distribute your intensity. Therefore, it is crucial that you get it right off the bat. For this episode, I welcome note just runners, but endurance athletes of all abilities, whether you are a cyclist, swimmer, cross-country skier, or triathlete, this episode in many ways applies to you. I hope you enjoy this episode of The Sunday Shakeout. Thank you so much to all of my listeners! Summary: -Three distinguishable intensity zones: Zone 1 (low-intensity), Zone 2 (moderate intensity), Zone 3 (high-intensity) -Training Intensity Distribution (TID): How much of the time we spend in different physiologically-based training intensity zones -Polarized and Pyramidal training models are proven to be the most effective -Approximately 80% of your training should be spent in Zone 1 and the other 20% should be spent in Zones 2 and 3 -Periodization and training personalization plays a great role in TID Helpful resources: -80/20 Running by Matt Fitzgerald https://www.amazon.com/80-20-Running-Stronger-Training/dp/0451470885 -Article: Training intensity distributions: From Polarized to Pyramidal models, specificity is key in Long Distance Triathlon https://www.trizone.com.au/training-intensity-distributions-from-polarized-to-pyramidal-models-specificity-is-key-in-long-distance-triathlon/ -Video: How "normal people" can train like the world's best endurance athletes | Stephen Seiler | TEDxArendal https://youtu.be/MALsI0mJ09I -Video: The Most Effective Endurance Training Method - The Science Explained https://www.youtube.com/watch?v=6KBBPOlyMWw

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.09.536148v1?rss=1 Authors: Wei, S., Chang, J., Jiang, J., Zhang, J., Wang, D., Li, Y., Chang, S., Li, H., Li, N. Abstract: Social novelty impairment is a hallmark feature of autism spectrum disorder associated with synaptic dysfunction. While G-protein coupled receptor 158 (GPR158) has been shown to be essential for synaptic neurotransmission, its role in modulating social novelty remains unknown. Here, we investigated the impact of GPR158 on social behavior in mice and observed that both constitutive and cell/tissue-specific knockout of Gpr158 in pyramidal neurons or the medial prefrontal cortex (mPFC) result in impaired novelty preference, but not sociability. Notably, we found a significant decline in excitatory synaptic transmission and glutamate vesicles in the mPFC synapses of global Gpr158 knockouts. Mechanistically, we identified that constitutive loss of Gpr158 led to suppressed Vglut1 distribution, possibly resulting from altered expression of vesicular V-ATPases and SNAREs by Gpr158 ablation in pyramidal neurons. Our findings suggest that GPR158 in pyramidal neurons specifically modulates social novelty and may be a potential therapeutic target for treating social disorders. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.03.535350v1?rss=1 Authors: Marasco, A., Tribuzi, C., Iuorio, A., Migliore, M. Abstract: Efficient and accurate large-scale networks are a fundamental tool in modelling brain areas, to advance our understanding of neuronal dynamics. However, their implementation faces two key issues: computational efficiency and heterogeneity. Computational efficiency is achieved using simplified neurons, whereas there are no practical solutions available to solve the problem of reproducing in a large-scale network the experimentally observed heterogeneity of the intrinsic properties of neurons. This is important, because the use of identical nodes in a network can generate artifacts which can hinder an adequate representation of the properties of a real network. To this aim, we introduce a mathematical procedure to generate an arbitrary large number of copies of simplified hippocampal CA1 pyramidal neurons and interneurons models, which exhibit the full range of firing dynamics observed in these cells - including adapting, nonadapting and bursting. For this purpose, we rely on a recently published adaptive generalized leaky integrate-and-fire (A-GLIF) modeling approach, leveraging on its ability to reproduce the rich set of electrophysiological behaviours of these types of neurons under a variety of different stimulation currents. The generation procedure is based on a perturbation of model's parameters related to the initial data, firing block, and internal dynamics, and suitably validated against experimental data to ensure that the firing dynamics of any given cell copy remains within the experimental range. This allows to obtain heterogeneous copies with mathematically controlled firing properties. A full set of heterogeneous neurons composing the CA1 region of a rat hippocampus (approximately 500K neurons), are provided in a database freely available in the live paper section of the EBRAINS platform. By adapting the underlying A-GLIF framework, it will be possible to extend the numerical approach presented here to create, in a mathematically controlled manner, an arbitrarily large number of non-identical copies of cell populations with firing properties related to other brain areas. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.29.534692v1?rss=1 Authors: Eom, K., Kim, Y., Baek, S., Park, A. J., Ho, W.-K., Lee, S.-H. Abstract: Neuronal excitability is a key determinant for recruitment of a neuron to an ensemble. High-frequency mossy fiber (MF) inputs induce prolonged increases in the excitability of a CA3 pyramidal cell (long-term potentiation of intrinsic excitability, LTP-IE), which primes the cell such that weak perforant pathway (PP) inputs can induce long-term potentiation at PP synapses (PP-LTP). However, sustained hyperexcitability can be detrimental, and a mechanism to reverse this state is necessary. Here, we show that burst firings of CA3 pyramidal cells elicited by PP or recurrent inputs reverse the MF-induced LTP-IE. Moreover, the high-frequency PP inputs to CA3-PCs already primed by MF inputs induced not only PP-LTP but also restored the high excitability state. Labeling neuronal ensemble using c-fos promoter in animals exposed to a novel context, we found most CA3 ensemble cells exhibited increased excitability, indicative of LTP-IE. Moreover, when the animals experienced novel contexts twice with a 30 min interval, a substantial subset of putative twice-activated CA3 ensemble cells exhibited reduced excitability, implying depotentiation of LTP-IE. We developed an in silico model based on the experimental results and found that MF-induced LTP-IE and its depotentiation are critical for the association of neuronal ensembles representing temporally spaced events. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.25.534233v1?rss=1 Authors: Virga, D. M., Hamilton, S., Osei, B., Morgan, A., Zamponi, E., Park, N. J., Hewitt, V. L., Zhang, D., Gonzalez, K. C., Bloss, E., Polleux, F., Lewis, T. L. Abstract: Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake, and therefore have instructive roles in synaptic function and neuronal response properties. Mitochondrial morphology differs significantly in the axon and dendrites of a given neuronal subtype, but in CA1 pyramidal neurons (PNs) of the hippocampus, mitochondria within the dendritic arbor also display a remarkable degree of subcellular, layer-specific compartmentalization. In the dendrites of these neurons, mitochondria morphology ranges from highly fused and elongated in the apical tuft, to more fragmented in the apical oblique and basal dendritic compartments, and thus occupy a smaller fraction of dendritic volume than in the apical tuft. However, the molecular mechanisms underlying this striking degree of subcellular compartmentalization of mitochondria morphology are unknown, precluding the assessment of its impact on neuronal function. Here, we demonstrate that this compartment-specific morphology of dendritic mitochondria requires activity-dependent, Camkk2-dependent activation of AMPK and its ability to phosphorylate two direct effectors: the pro-fission Drp1 receptor Mff and the recently identified anti-fusion, Opa1-inhibiting protein, Mtfr1l. Our study uncovers a new activity-dependent molecular mechanism underlying the extreme subcellular compartmentalization of mitochondrial morphology in dendrites of neurons in vivo through spatially precise regulation of mitochondria fission/fusion balance. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.04.529157v1?rss=1 Authors: Wu, J., El-Hassar, L., Datta, D., Thomas, M., Zhang, Y., Jenkins, D. P., DeLuca, N. J., Chatterjee, M., Gribkoff, V. K., Arnsten, A. F. T., Kaczmarek, L. K. Abstract: The ability of monkeys and rats to carry out spatial working memory tasks has been shown to depend on the persistent firing of pyramidal cells in the prefrontal cortex (PFC), arising from recurrent excitatory connections on dendritic spines. These spines express hyperpolarization-activated cyclic nucleotide-gated (HCN) channels whose open state is increased by cAMP signaling, and which markedly alter PFC network connectivity and neuronal firing. In traditional neural circuits, activation of these non-selective cation channels leads to neuronal depolarization and increased firing rate. Paradoxically, cAMP activation of HCN channels in PFC pyramidal cells reduces working memory-related neuronal firing. This suggests that activation of HCN channels may hyperpolarize rather than depolarize these neurons. The current study tested the hypothesis that Na+ influx through HCN channels activates Na+-activated K+ (KNa or Slack) channels to hyperpolarize the membrane. We have found that HCN and Slack KNa channels co-immunoprecipitate in cortical extracts and that, by immunoelectron microscopy, they colocalize at postsynaptic spines of PFC pyramidal neurons. A specific blocker of HCN channels, ZD7288, reduces KNa current in pyramidal cells that express both HCN and Slack channels, indicating that blockade of HCN channels reduced K+ current indirectly by lowering Na+ influx. In contrast, ZD7288 has no effect on KNa currents in an HEK cell line stably expressing this Slack channels but no HCN channels, demonstrating that ZD7288 does not block Slack channels directly. Activation of HCN channels by cAMP in a cell line expressing a Ca2+ reporter results in elevation of cytoplasmic Ca2+, but the effect of cAMP is completely reversed if the HCN channels are co-expressed with Slack channels. Finally, we have used a novel pharmacological blocker of Slack channels to show that inhibition of either Slack or HCN channels in rat PFC improves working memory performance, and that the actions of Slack and HCN channel blockers occlude each other in the memory task. Our results suggest that the regulation of working memory by HCN channels in PFC pyramidal neurons is mediated by an HCN-Slack channel complex that links activation HCN channels to suppression of neuronal excitability. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.13.528352v1?rss=1 Authors: Inibhunu, H., Chameh, H. M., Skinner, F., Rich, S., Valiante, T. A. Abstract: Discerning the contribution of specific ionic currents to complex neuronal dynamics is a difficult, but important, task. This challenge is exacerbated in the human setting, although the widely-characterized uniqueness of the human brain as compared to preclinical models necessitates the direct study of human neurons. Neuronal spiking frequency preference is of particular interest given its role in rhythm generation and signal transmission in cortical circuits. Here, we combine the frequency-dependent gain (FDG), a measure of spiking frequency preference, and novel in silico analyses to dissect the contributions of individual ionic currents to key FDG features of human L5 neurons. We confirm that a contemporary model of such a neuron, primarily constrained to capture subthreshold activity driven by the hyperpolarization-activated cyclic nucleotide gated (h-) current, replicates key features of the in vitro FDG both with and without h-current activity. With the model confirmed as a viable approximation of the biophysical features of interest, we applied new analysis techniques to quantify the activity of each modeled ionic current in the moments prior to spiking, revealing unique dynamics of the h-current. These findings motivated patch-clamp recordings in analogous rodent neurons to characterize their FDG, which confirmed that a biophysically-detailed model of these neurons captures key inter-species differences in the FDG. These differences are correlated with distinct contributions of the h-current to neuronal activity. Together, this interdisciplinary and multi-species study provides new insights directly relating the dynamics of the h-current to neuronal spiking frequency preference in human L5 neurons. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.14.528554v1?rss=1 Authors: Jin, S., Chen, X., Tian, Y., Jarvis, R., Promes, V., Yang, Y. Abstract: Developing astroglia play important roles in regulating synaptogenesis through secreted and contact signals. Whether they regulate postnatal axon growth is unknown. By selectively isolating exosomes using size-exclusion chromatography (SEC) and employing cell-type specific exosome reporter mice, our current results define a secreted astroglial exosome pathway that can spread long-range in vivo and stimulate axon growth of cortical pyramidal neurons. Subsequent biochemical and genetic studies found that surface expression of glial HepaCAM protein essentially and sufficiently mediates the axon-stimulating effect of astroglial exosomes. Interestingly, apolipoprotein E (ApoE), a major astroglia-secreted cholesterol carrier to promote synaptogenesis, strongly inhibits the stimulatory effect of astroglial exosomes on axon growth. Developmental ApoE deficiency also significantly reduces spine density of cortical pyramidal neurons. Together, our study suggests a surface contact mechanism of astroglial exosomes in regulating axon growth and its antagonization by ApoE, which collectively coordinates early postnatal pyramidal neuronal axon growth and dendritic spine formation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.07.527321v1?rss=1 Authors: Moore, T. L., Medalla, M., Ibanez, S., Wimmer, K., Mojica, C., Killiany, R. J., Moss, M. B., Luebke, J. I., Rosene, D. L. Abstract: Age-related declines in cognitive abilities occur as early as middle-age in humans and rhesus monkeys. Specifically, performance by aged individuals on tasks of executive function (EF) and working memory (WM) is characterized by greater frequency of errors, shorter memory spans, increased frequency of perseverative responses, impaired use of feedback and reduced speed of processing. However, how aging precisely differentially impacts specific aspects of these cognitive functions and the distinct brain areas mediating cognition are not well understood. The prefrontal cortex (PFC) is known to mediate EF and WM and is an area that shows a vulnerability to age- related alterations in neuronal morphology. In the current study, we show that performance on EF and WM tasks exhibited significant changes with age and these impairments correlate with changes in biophysical properties of L3 pyramidal neurons in lateral LPFC (LPFC). Specifically, there was a significant age-related increase in excitability of Layer 3 LPFC pyramidal neurons, consistent with previous studies. Further, this age-related hyperexcitability of LPFC neurons was significantly correlated with age- related decline on a task of WM, but not an EF task. The current study characterizes age- related performance on tasks of WM and EF and provides insight into the neural substrates that may underlie changes in both WM and EF with age. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this episode, Tony walks Lee and Craig through the mythos and history of the band TOOL. == WHAT WE'RE LISTENING TO & RECOMMEND == CRAIG Listening to & Recommends Doug Gertner on AfterFM.com LEE Listening to Riverside - ID.Entity TONY Listening to Rick Wakeman - A Gallery of the Imagination Listening to Peter Gabriel - Panopticom Recommends TOOL - Flood Recommends (Maynard) Puscifer - Momma Sed Recommends (Danny) Pigmy Love Circus - Pistolero Sleep == UNHEARD OF == The Flying Caravan (Spain / España) The idea of The Flying Caravan arose in Antonio Valiente´s mind, a musician from Alicante, born in 1970. Antonio began playing the guitar at age 13 having Mark Knopfler as his main musical influence and using fingerpicking as his preferred style. Since he was 18, he has learned technique and modern harmony with different teachers. From 2000, Antonio has been focusing on the idea of developing his own compositions, and after four years of work Juanjo Sánchez (keyboard} and Keeng {The Satellites) joined the project that would finally take shape as The Flying Caravan. However, it was when Izaga Plata (vocals–Head Over Hell) entered back in 2014 that she and Antonio developed the melodies and lyrics that would make up the album. With the arrival of Pedro Pablo Molina (bass player-El Interior), Lluís Mas (drummer-Pyramidal, Adam Giles Levy) and Juanjo´s return to the band, the project got established. The band recorded “I Just Wanna Break Even” at the Facultad de Bellas Artes of the UMH in Altea (Alicante) between May and August 2017 with Daniel Montiel as a recording engineer and Lluís Mas and Antonio Valiente as producers, after several recording sessions and a two-year production period. The audio mixing and mastering were carried out at Lluís Mas (Oriental Desert Studio Audio). The album features the extraordinary collaborations of Manolo Salido (sax-M Clan, Loquillo), Juan Carlos Aracil (flute- El Bicho, Tino di Geraldo) and Jorge Aniorte (voice-Liverpool Band). Web Facebook Instagram Twitter BandCamp YouTube Spotify == SUPPORT THE SHOW ==  Help support UP3Show financially at: patreon.com/up3show NOW FEATURES BONUS CONTENT AND EXTRAS! Check out our new homepage at up3show.com! Follow us on Twitter: UP3Show: @up3show

Luca Filipas a PhD researcher and coach out of Milan, Italy. Re-Release episode from January 2022.You can find Luca's work here- https://www.lucafilipas.com/Luca on Instagram- https://www.instagram.com/lucafilipasLuca on Twitter- https://twitter.com/LucaFilipasPaper discussed- Effects of 16 weeks of pyramidal and polarized training intensity distributions in well-trained endurance runnersBuy Koop's new book on Amazon or Audible.Information on coaching-www.trainright.comKoop's Social MediaTwitter/Instagram- @jasonkoop

Welcome to Live From Progzilla Towers Edition 421. In this edition we heard music by Supertramp, Jadis, Abel Marton Nagy's Cosmos Band, Enochian Theory, Fufluns, Hedvig Mollestad Trio, Camel, Clearlight, Karmamoi, Panzerpappa, Pyramidal, Hydravion, Bland Bladen, Jean-Michel Jarre, King Crimson, Nad Sylvan, Pesky Gee!, Hostsonaten, Cyril, Vienna Circle, The Deep Freeze Mice & 10CC.

Luca Filipas, PhD, is a researcher at the University of Milan and an endurance sports coach of professional and amateur runners, cyclists, and triathletes. In this interview, we discuss his recent study comparing polarised, pyramidal, and combined POL-PYR or PYR-POL training intensity distributions, and the applications of this research in planning a periodised endurance training plan.  IN THIS EPISODE YOU'LL LEARN ABOUT: -How combining pyramidal and polarised training blocks (in that specific order) may be a more effective periodisation scheme to optimise endurance performance -How the goal event (e.g. 5k vs. marathon running) might influence and change these findings -The alignment of a pyramidal-polarised periodisation with classic tapering and peaking research -Periodisation across a season: the importance of downtime and careful race planning -Luca's coaching methodology and top tips for endurance athletes SHOWNOTES: https://scientifictriathlon.com/tts328/ SCIENTIFIC TRIATHLON AND THAT TRIATHLON SHOW WEBPAGE: www.scientifictriathlon.com/podcast/ SPONSORS: ROKA - Exceptional quality triathlon wetsuits, trisuits, swimskins, goggles, performance sunglasses as well as prescription eyeglasses and sunglasses.  Online vision test for prescription updates and home try-on options available for eyeglasses. Ships from  the US, UK and EU. Trusted by world-leading athletes such as  Lucy Charles-Barclay, Javier Gómez Noya, Flora Duffy, Morgan Pearson, Summer Rappaport and others in triathlon, cycling, speed skating, and many more. Visit roka.com/tts for 20% off your order. ZEN8 - The ZEN8 Indoor Swim Trainer is a one of a kind swim bench for time-crunched triathletes looking to improve their swim technique, power and propulsion, and consistency of swim training. It is very affordable, about the price of a pair of running shoes, and Zen8 offer free shipping in the US and the UK. Best of all, you can try it risk-free. If you don't love it after two weeks, send it back and get a full refund. Get 20% off your order at zen8swimtrainer.com/tts. LINKS AND RESOURCES: Luca's website, Instagram, Twitter and Research Gate Effects of 16 weeks of pyramidal and polarized training intensity distributions in well-trained endurance runners - Filipas et al. 2021 The training intensity distribution among well-trained and elite endurance athletes - Stöggl and Sperlich 2015 The integration of training and off-training activities substantially alters training volume and load analysis in elite rowers - Treff et al. 2021 Tapering, periodisation and recovery with Iñigo Mujika, PhD | EP#256 Scientific Training for Endurance Athletes with Dr. Philip Skiba | EP#311 RATE AND REVIEW: If you enjoy the show, please help me out by subscribing, rating and reviewing: www.scientifictriathlon.com/rate/ CONTACT: Want to send feedback, questions or just chat? Email me at mikael@scientifictriathlon.com or connect on Instagram, Facebook, or Twitter.

Should you be doing pyramidal training only, pyramidal training only, or a mix of both? Which format is most effective? This is a controversial topic and one we're going to dive deep into today in this episode of the FasCat Coaching podcast. More specifically, there have been a few recent studies released, as well as debates happening, within the scientific community that we will dissect, followed by Coach Christian and myself sharing our thoughts and experience on the subject. What we discuss: - A recent study was done on the “Effects of 16 weeks of pyramidal and polarized training intensity distributions in well-trained endurance runners”. The study compares 4 different groups: 16 weeks of polarized, 16 weeks of pyramidal, 8 weeks of polarized then 8 weeks of pyramidal, and 8 weeks of pyramidal then 8 weeks of polarized. - Sports Science journal series of debate articles titled “Polarized Training is Not Optimal for Endurance Athletes” and “Polarized Training is Optimal for Endurance Athletes.” The author and columnist for Outside Magazine, Alex Hutchinson, wrote an excellent summation (and to an extent, take-down) of these arguments in his column Sweat Science.  - Olympic Speedskater Nils van der Poel's 60 page PDF directing his training plan for the Olympics. Van der Poel is a speedskater from Sweden who recently won Olympic gold in the 5,000 and 10,000 meters, setting world records in the process. You can check out his pdf here: e11bfe_b783631375f543248e271f440bcd45c5.pdf (howtoskate.se) Sources: 1.  Polarized Training is Not Optimal for Endurance Athletes Burnley, Mark; Bearden, Shawn; Jones, Andrew Medicine & Science in Sports & Exercise AN: 00005768-900000000-95869 February 2022 2.  Polarized Training is Optimal for Endurance Athletes Foster, Carl; Casado, Arturo; Esteve-Lanao, Jonathan; Haugen, Thomas; Seiler, Stephen Medicine & Science in Sports & Exercise AN: 00005768-900000000-95872 February 2022 Get started with FasCat: www.fascatcoaching.com

Der (sport-)wissenschaftliche Mob tobt; die Diskussion zu polarisiertem Training spaltet die Gesellschaft. Die Aussage, dass polarisiertes Training „optimal for endurance athletes“ sei, löst in der Wissenschaft eine spannende Diskussion über Periodisierung, Polarisierung und Pyramiden aus. In der 50. Folge des HYCYS Podcasts „Junkmiles“ nehmen sich Daniel Beck (Journalist) und Björn Geesmann (Sportwissenschaftler) der Diskussion über polarisiertes Training an und erläutern, warum der Kern der Diskussion vielleicht am eigentlichen Trainingsgedanken vorbei geht; warum aber polarisiertes Training durchaus Sinn machen kann. Polar oder Pyramide – alles in der neuen Junkmiles-Folge!

In this episode, Coach Frank Overton and Coach Christian Parrett discuss what pyramidal training is, research studies from world tour athletes that support its use, real-world examples of how pyramidal training differs from polarized training, and why the 'Polarized versus Sweet Spot Training' is a false debate. 

Podcast put out by the faculty at WCU LA for students with an aim at sharing NCLEX tips, testing tips, topic explanation, and any questions WCU grads and current students may have! To contact Joan Wheeler about ATI/VATI/Board Vital resources or to do your weekly check-in, email her at jwheeler@westcoatuniversity.edu To request particular topics to be discussed in our podcasts email me at dreid@westcoastuniversity.edu or message me on Remind --- Send in a voice message: https://anchor.fm/wculaoperationpassnclex/message