POPULARITY
5 episodes with Pemphigus
2 episodes with Pemphigus
2 episodes with Pemphigus
2 episodes with Pemphigus
It can be difficult to differentiate pemphigus foliaceus (PF) in certain cases. If there is a lot of infection or inflammation, it can be difficult to tell if the case is autoimmune or allergic. However, there are a few hints between dogs and cats that can give you an indication you are dealing with PF.In dogs, honey colored adherent crusting, facial lesions, nasal planum involvement and crust paw pads can occur with PF. In cats, purulent debris at the claw folds, crusting/erythema around the nipples and crusting/erythema to the pinna can be hints of PF.As always, check cytology and look for neutrophilic inflammation without infection and/or acantholytic keratinocytes (prematurely lifted skin cells). Learn more details on this week's episode of The Derm Vet podcast!TIMESTAMPS00:00 Intro01:53 Dogs and Pemphigus04:29 Oral Mucosa06:00 Cats and Pemphigus09:53 Cytology and Pemphigus 12:53 Summary
In this episode, we review the high-yield topic of Pemphigus Vulgaris from the Dermatology section.FollowMedbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Another grab bag episode of the podcast, you submitted questions about AUTOIMMUNE DISEASES on Instagram. Here is some information that goes through sebaceous adenitis treatment, ear margin vasculitis differentials, topicals for autoimmune diseases and more!TIMESTAMPSIntro 00:00Treatment Options For Sebaceous Adenitis 01:02Mycophenolate In Autoimmune Cases 05:35High Dose Prednisone Protocol 07:10Treating With Antibiotics Before Biopsying An Autoimmune Case 09:04Rule Outs For Ear Margin Vasculitis 11:30Topicals For Autoimmune Diseases 14:20Outro 16:36
What are things you should consider when approaching a case with an immune mediated disease?Check out this week's episode of The Derm Vet podcast!
In this insightful episode, Dr. Hannah Kopelman delves into the complex world of pemphigus and pemphigoid with Dr. Animesh Sinha, former chair of dermatology at the University of Buffalo and an accomplished researcher, Dr. Sinha shares his extensive knowledge on the intricacies of pemphigus and pemphigoid. His expertise illuminates the multifactorial and polygenic nature of these conditions, highlighting the pivotal role of genetic and environmental factors in their development. The discussion provides a deeper understanding of autoimmune diseases, their diagnosis, and the challenges faced in pinpointing their precise causes. Please SUBSCRIBE to the Derm Club Podcast wherever you like to listen whether on YouTube, Apple, or Spotify. Together, let's explore the fascinating secrets of dermatology and skincare. Connect with me across Social: Twitter: https://twitter.com/drhankopelman Instagram: https://www.instagram.com/doctor.han/ TikTok: https://www.tiktok.com/@drhankopelman Blog: https://www.hannahkopelman.com/blog/ The content of this podcast is for entertainment and educational purposes only. This content is not meant to be a substitute for medical advice or treatment for any medical condition. --- Send in a voice message: https://podcasters.spotify.com/pod/show/hannah-kopelman/message
Martine Hackett returns with a new season of “Untold Stories: Life with a Severe Autoimmune Condition.” Hear from people forging new paths after diagnosis, and learn how they build community and evolve their outlook on life. We'll learn more about life with myasthenia gravis (MG) and chronic inflammatory demyelinating polyneuropathy (CIDP), and even hear from people living with autoimmune conditions such as pemphigus. Join us starting Wednesday, December 27th.See omnystudio.com/listener for privacy information.
We often talk about pemphigus foliaceus... but did you know there are other forms of pemphigus? Learn some of the differences in distribution, pathology and species on this week's episode of The Derm Vet podcast!
Log this CPD with 1CPD here (00:00) John introduces today's guest - host of another veterinary dermatology podcast The Derm Vet, Ashely Bourgeois. Chapter 1: UK vs US Dermatology (02:50) Sue asks Ashley how she started out in podcasts and Ashley shares her story, wanting to stay involved in dermatology whilst also raising children and not wanting to lose that knowledge base, and helping others in that kind of position. (04:33) John asks Ashely and Sue what the difference between the UK and US in approach to dermatology. Sue says the approach is the same, but the system is slightly different and there isn't so much of a referral process in the US as here in the UK. Ashley agrees, saying often people will come direct, but that they have good relationships with first opinion practices in order that clients are aware dermatologists exist. (06:45) Sue says the board certified dermatologists exist in both regions, but in the UK we have an intermediate tier of advanced practitioners which doesn't exist in the states; therefore asking Ashley if there are any areas in the US which aren't covered well geographically with specialists. Ashley says there are areas without specialists, and there is work to see if they can develop better coverage; including the possibility of telemedicine in for example a state that doesn't have dermatologists. (08:58) Sue asks if the rules around dermatology prescribing through telemedicine differs state to state and Ashley confirms this, saying in her state for example, they must see a client at least once a year whereas in other states this is possible long term remotely. Chapter 2: UK vs US Antibiotic Use (11:30) Ashley then asks Sue if it differs in relation to staphylococcus infections in the UK and US and Sue says it really does, and also across Europe from the UK. She points out in Scandinavia they hardly use antibiotics at all and use antiseptics much more, and this seems to really correlate to having less resistance. Sue asks for example if Ashely would use vancomycin and Ashely says whilst she hasn't for this one she has had to use rifampin and chloramphenicol. She reflects there is a shift in the mindset with the use of antibiotics because of the number of times they will only have one or two choices left due to resistance. (14:45) Sue asks if it is right you can buy neomycin, polymyxin, bacitracin over the counter and Ashely says you can for topicals, and said she even had a client who had fish antibiotics they were giving to their dog whenever they felt there was an infection. Sue reflects what would be available by comparison in the UK. Chapter 3: UK vs US In Practice (17:17) John asks whether a clients expectation would differ in terms of approach to a skin case in the states than in the UK and Ashley says there is much the same issue in terms of clients not understanding the long term nature of skin management, particularly in allergy and also the multimodal approach; where often more than one therapy is going to manage the patients skin. She is always quick to point out to owners these cases will change and even when well managed, this will change and they will flare up. (20:14) John reflects that in the US the Vet nurses or Vet Techs as they are called there are still as important to case management as here in the UK and Ashely passionately agrees, saying they are critical to the solidification of a case management – instilling confidence in the owners to the treatment plan long term. They also catch mistakes and understand the cases very well. (23:05) John asks Ashely about the education side in terms of the difference with logging CPD and education. Ashley says the regulations are quite strict in terms of whether she can talk off label at lectures and online and her and Paul reflect on some of these aspects. Chapter 3: UK vs US Dermatology Top Trumps (26:27) Sue asks Ashley for most common presentations and Ashley and Sue spend some time reflecting on the differing cases and presentations seen both in the US and UK. Where Ashely is in the US the climate is similar but Sue reflects it is interesting how the diseases are so different. (33:50) John wraps the podcast by asking Sue and Ashley what their favourite and least favourite disease it. Pemphigus comes out well whilst sterile nodular panniculitis and bald Pomeranians/alopecia X and lick granulomas really don't! Visit Ashley's Website HERE Search The Derm Vet Podcast on your podcast platform, or follow the link HERE
In this episode, we review the high-yield topic of Pemphigus Vulgaris from the Dermatology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets
Clippings: The Official Podcast of the Council for Nail Disorders
"Nail changes in pemphigus and bullous pemphigoid: A single-center study in China." Cao, Shan, et al. Frontiers in Medicine 9 (2022)."Metastases to the nail unit and distal phalanx: a systematic review.” Curtis, Kaya L., and Shari R. Lipner. Archives of Dermatological Research (2022): 1-12.
Was ist eine Pemphigus vulgaris? Wie wird man Symtome der Bronchitis wieder los? Wie tun bei Pilzinfektionen? Muss man Bedenken vor einer Narkose haben? Antje Bergmann hat Ihre Fragen beantwortet.
Dr. Sergei Grando discusses his multidrug protocol shown to offer potential cure for the majority of pemphigus and pemphigoid patients.
Join Yvonne Brandenburg, RVT, VTS SAIM and Jordan Porter RVT, LVT, VTS SAIM as we talk about: When dermatology and internal medicine collide. We are discussing the autoimmune derm issue that is Pemphigus. Question of the Week What would you like to hear us talk about? Resources We Mentioned in the Show Pemphigus 2008: Pathogenesis, Presentation, & Management ACVIM 2008 Danny W. Scott, DVM, DACVD https://www.vin.com/apputil/content/defaultadv1.aspx?pId=11262&catId=32563&id=3865432 Canine and feline pemphigus foliaceus: Improving your chances of a successful outcome https://www.dvm360.com/view/canine-and-feline-pemphigus-foliaceus-improving-your-chances-successful-outcome Tham, H.L., Linder, K.E. & Olivry, T. Deep pemphigus (pemphigus vulgaris, pemphigus vegetans and paraneoplastic pemphigus) in dogs, cats and horses: a comprehensive review. BMC Vet Res 16, 457 (2020). https://doi.org/10.1186/s12917-020-02677-w Almela, R., Chan, R. Review of Pemphigus Foliaceus in Dogs and Cats TVP Today's Veterinary Practice (2020). https://todaysveterinarypractice.com/dermatology/review-of-pemphigus-foliaceus-in-dogs-and-cats/ Thanks so much for tuning in. Join us again next week for another episode! Want to earn some RACE approved CE credits for listening to the podcast? You can earn between 0.5-1.0 hour of RACE approved CE credit for each podcast episode you listen to. Join the Internal Medicine For Vet Techs Membership to earn and keep track of your continuing education hours as you get your learn on! Join now! http://internalmedicineforvettechsmembership.com/ Get Access to the Membership Site for your RACE approved CE certificates Sign up at https://internalmedicineforvettechsmembership.com Get Access to the Technician Treasure Trove Sign up at https://imfpp.org/treasuretrove Thanks for listening! – Yvonne and Jordan
In this episode, we review the high-yield topic of Pemphigus Vulgaris from the Dermatology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://anchor.fm/medbulletsstep1/message
This week esteemed Professor Branka Marinović shares her experience as Secretary General of the EADV (2017-2021) and reflects on some significant ways how the Academy has changed in the past years. Join us as Prof. Marinovic talks about how the “Updated S2K guidelines on the management of pemphigus vulgaris and foliaceus” facilitated the everyday work of Dermatologists and improved quality of care. Finally, the importance of collaboration between the Autoimmune Blistering Diseases Task Force of the EADV and patient organizations is also highlighted. The guidelines can be read here: Updated S2K guidelines on the management of pemphigus vulgaris and foliaceus initiated by the EADV
Tagtäglich schützt das Immunsystem den Menschen vor Angriffen und Schäden durch zahllose/verschiedenste Krankheitserreger in seiner Umwelt. Doch wie genau funktioniert der biologische Schutzschild des Menschen eigentlich? Warum sind Entzündungen dabei überlebenswichtig und was hat es mit Autoimmunerkrankungen auf sich? All das gilt es in der 27. Folge des Underdocs Podcasts herauszufinden. Dabei handelt es sich nicht um eine reguläre Ausgabe, sondern um den ersten Teil unserer Doppelfolge über das Forschungskonsortium „Pegasus“, in dem nach Therapiemöglichkeiten für Pemphigus sucht, welche eine verheerende und seltene Autoimmunerkrankung der Haut ist. Um erstmal die wichtigsten Grundbegriffe zu klären und einen kleinen Einblick Mysterien des Immunsystems zu gewinnen, unterhält sich unsere Moderatorin, Paula Mörstedt, mit Herrn Prof. Dr. Michael Hertl, der sich als Direktor der Klinik für Dermatologie und Allergologie an dem Universitätsklinikum Gießen und Marburg bestens mit dem Thema auskennt.
TDC Host: Cameron Wells --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app
Listen to this episode to know more about pemphigus. Do you want to know more about oral diseases? Follow us on Instagram @doencasdeboca https://www.instagram.com/doencasdeboca/
In this episode, we discuss rare disease dermatology with Dr. Steven Chen, MD of Harvard Medical School. Pemphigus and pemphigoid are rare, auto-immune blistering diseases that affect the skin. Learn more about these two conditions at the International Pemphigus and Pemphigoid Foundation. Find out more about Dr. Chen's work in the field of dermatology here.
Cases of feline pemphigus can develop very severe lesions and be intimidating. However, recognizing the lesion distribution and performing appropriate diagnostics can provide a definitive diagnosis. This allows the veterinarian to treat or refer to a dermatologist. Appropriate management of these cases can lead to a normal quality of life (with some vet visits sprinkled in). Learn the basics regarding diagnostics and treatment of this kitty autoimmune disease!
Pemphigus is an uncommon intraepidermal blistering disease occurring on the skin and mucous membranes. It is caused by autoantibodies to adhesion molecules expressed in the skin and mucous membranes. The cause is unknown. The bullae appear spontaneously and are tender and painful when they rupture. Drug induced pemphigus from penicillamine, captopril, and others have been reported. There are several forms of pemphigus: pemphigus vulgaris and its variant, pemphigus vegetans; and the more superficially blistering pemphigus foliaceus and its variant, pemphigus erythematosus. All forms may occur at any age, but most present in middle age. The foliaceus form is especially apt to be associated with other autoimmune diseases, or it may be drug induced. Paraneoplastic pemphigus, a unique form of the disorder, is associated with numerous types of benign and malignant neoplasms (typically non-Hodgkin lymphoma). Pemphigus is characterized by an insidious onset of flaccid bullae, crusts, and erosions in crops or waves. In pemphigus vulgaris, lesions often appear first on the oral mucous membranes. These quickly become erosive. The scalp is another site of early involvement. Practitioners can rub a cotton swab or finger laterally on the surface of uninvolved skin which may cause easy separation of the epidermis (this is Nikolsky's sign). The diagnosis is made with light microscopy and by direct and indirect immunofluorescence (IIF) microscopy. Autoantibodies to intercellular adhesion molecules can be detected with ELISA assays and have replaced the use of IIF in some centers. When the condition is severe, patients should be hospitalized at bed rest and given antibiotics/intravenous feedings. Anesthetic troches used before eating ease painful oral lesions. While pemphigus requires systemic therapy as early as possible, ironically, the main morbidity here is side effects from treatment. Initial therapy with systemic corticosteroids can consist of prednisone (60-80 mg daily). In most cases, a steroid sparing agent is added at the beginning at treatment (ex. azathioprine 100-200 mg daily, mycophenolate mofetil 1-1.5 twice daily). Treatment courses can be repeated in patients who do not achieve complete remission or relapse (ex. monthly IVIG at 2 g/kg intravenously over 3-4 days). In refractory cases, cyclophosphamide plus intravenous corticosteroids and plasmapheresis are also used. In patients who have a limited form of the disease, skin and mucous membrane lesions should be treated with topical corticosteroids. Complicating infection requires appropriate systemic and local antibiotic therapy. As far as complications are concerned, secondary infection can occur. This is a major cause of morbidity and mortality. Disturbances of fluid, electrolyte, and nutritional intake can occur as a result of painful oral ulcers. One in three patients will experience remission and, infection from S. aureus is the most frequent fatality cause. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app
I am joined by Dr. Melissa Hall, DVM, Dip ACVD from Metropolitan Animal Specialty Hospital (Los Angeles, CA) to discuss pemphigus foliaceus. This is one of the more common cutaneous autoimmune diseases diagnosed in cats and dogs. It can be an incredibly rewarding disease to manage, but also a very frustrating one.Dr. Hall and I cover the clinical signs, how to successfully diagnose with cytology and biopsy, and treatment options for dogs and cats with pemphigus foliaceus. It is a fun conversation about a disease process you may see in your clinic!
Dr Sarah Bell, a consultant Dermatologist in Lincolnshire, joins MEMcast this week to discuss the clinical features of Bullous Pemphigoid and how to distinguish it from Pemphigus.
Your daily COVID-19 LST Report: — Climate: COVID-19 brings to light the need for universal health care services and Italian authors demand further government investments in the development of such structures. The COVID-19 pandemic has created dissonance between practicality and the traditional four pillars of medical ethics: autonomy, beneficence, non-maleficence, and justice. — Epidemiology: Authors speculate that anosmia is a specific symptom that can be used as a cheap and effective screening tool for COVID-19. Coupled with the fact that olfactory mucosa has a high expression of ACE2 transcript, they speculate that anosmia is due to direct damage to neuroepithelial stem cells. — Understanding the Pathology: An author presents a possible explanation for thromboses in COVID-19 patients. They speculate that the virus could attack erythrocytes directly, resulting in antigen-antibody immune complex formation. This type III hypersensitivity reaction would release proteases that could destroy epithelium, mesothelium, and endothelium basement membrane as well as create antiphospholipid antibodies, which could lead to thrombosis. — Transmission and Prevention: A bioengineer affiliated with the Imperial College in London questions whether 2 meters (approximately 6.6 feet) is an appropriate distance for preventing droplet transmission of SARS-CoV-2 based on studies demonstrating exhalation behavior and travel of exhaled tobacco smoke (a possible surrogate for droplets) reaching a distance of up to 9 meters. — Management: Guidelines and recommendations for managing COVID-19 patients include: Post-extubation airway obstruction including laryngospasm, Triaging newborns with mothers who are COVID-19 positive, Pemphigus vulgaris patients, Osteoarthritis patients — Mental Health and Resilience: Impacts on vulnerable populations and what we can do. — Silver Lining: French patients with OSA, are now using their CPAP more. — Visit COVID19LST.org for our full report with links to the articles. — Reach out to us at: contact@covid19lst.org --- Support this podcast: https://anchor.fm/covid19lst/support
For today's episode we will be reviewing three more articles from the Jan-Feb 2020 issue of Allergy Watch, a bimonthly publication which provides research summaries to College members from the major journals in allergy and immunology. You can also earn CME credit by listening to this podcast! For information about CME credit, head over to https://college.acaai.org/allergytalk Article Links: The clinical benefit of mepolizumab replacing omalizumab in uncontrolled severe eosinophilic asthma. Altered Viscosity of Nasal Secretions in Postnasal Drip. Walnut antigens can trigger autoantibody development in patients with pemphigus vulgaris through a "hit-and-run" mechanism. Please rate our podcast on iTunes! Please give us feedback, corrections, and suggestions! Email feedback to: allergytalk@acaai.org ACAAI is presenting this podcast for educational purposes only. It is not medical advice or intended to replace the judgment of a licensed physician. The College is not responsible for any claims related to procedures, professionals, products or methods discussed in the podcast, and it does not approve or endorse any products, professionals, services or methods that might be referenced. Today's speakers have the following disclosures: Drs. Lee and Kalangara have nothing to disclose. Dr. Fineman Speaker: AstraZenca, Boehringer Ingelheim, Shire; Research: Aimmune, DBV, Shire, Regeneron.
Succes I Veterinær Praksis Podcast - Sammen om at blive bedre
Noter og links på: SIVP.dk/124 Dyrlæge Nanna Enemark arbejder på Anicura Aarhus Dyrehospital, hvor hun modtager medicinske henvisningspatienter, herunder hud- og mavetarmpatienter. I denne podcast deler Nanna ud af sin erfaring og fortæller om, hvordan vi diagnosticerer og behandler pemphigus foliaceus.
This educational activity will discuss treatment strategies for patients with pemphigus vulgaris.
This educational activity will provide insight into making a timely and accurate diagnosis of pemphigus vulgaris.
Skin appearance is a sign of internal health, and patients who have appropriate vitamin levels naturally have healthier skin. Dr. Vincent DeLeo talks with Dr. Gary Goldenberg about the data on vitamins and supplements that have been shown to improve the skin’s appearance and health. Dr. Goldenberg discusses the controversies surrounding the quality of products and the need for dermatologists to remain up-to-date on products their patients may be taking already. “A discussion of nutrition and supplements really is a part of any dermatologic evaluation, just like skin care should be part of every dermatologic evaluation,” advises Dr. Goldenberg. * * * Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 * * * We bring you the latest in dermatology news and research: 1. Rituximab bests mycophenolate in pemphigus vulgaris Rituximab showed a superior overall benefit/risk profile, compared with mycophenolate mofetil. 2. Once-daily oral JAK inhibitor for atopic dermatitis effective in phase 3 study Abrocitinib may have taken a step closer to becoming the first once-daily oral Janus kinase 1 inhibitor to be approved for atopic dermatitis. 3. Online resources influencing cosmetic treatment choices Rate and review websites affect almost 70% of consumers seeking providers for cosmetic procedures. * * * Things you will learn in this episode: Patients who have good nutrition also will have appropriate vitamin levels, which contributes to having healthier skin. Dr. Goldberg explains, “Patients who have really low vitamin D levels will not be as healthy and cannot have as healthy skin as those who have more normal vitamin D levels.” Studies have shown that internal vitamin C levels reduce oxidative stress and help with the appearance of fine wrinkles, lines, and pigmentation. “As far as topical vitamin C goes, I think that there [are] good data showing that vitamin C improves the appearance of skin. But the issue with vitamin C is the delivery of the product into the skin,” advises Dr. Goldenberg. Vitamin E is one of the best antioxidants, according to Dr. Goldenberg, and is especially helpful for UV-induced oxidative stress. Carotenoids, which are derived from vitamin A, can help reduce oxidative stress associated with UV-induced radiation and UV-induced erythema. “We also know that carotenoids actually improve UV-damaged cells such as for patients with a history of skin cancer,” says Dr. Goldenberg. Studies have reported that oral collagen supplements can improve skin health and appearance. However, Dr. Goldenberg remains skeptical: “It’s still unclear to me if the improvement is due to the actual collagen or to the water that patients may be taking the collagen in, especially if it’s a powder.” Hydration is very important for skin appearance and health, he adds. Imedeen supplementation has some data that show antioxidant properties. Although it’s too early to say that Imedeen is completely effective, studies report efficacy for skin appearance and health. In terms of side effects associated with vitamins and supplements, Dr. Goldenberg advises that not all supplements have the same quality, and patients should consult a nutritionist for advice on which vitamins and supplements are needed. “Not all supplements are going to have the same quality. So if you’re going with the least expensive ones, they may have the least absorption. Now the most expensive ones may have the prettiest packaging and not necessarily be the highest quality of the vitamin.” Dermatologists, as skin experts, need to be aware of the data on vitamins and supplements because diet or nutrition is a common question among patients. For example, patients with acne, psoriasis, eczema, or rosacea may inquire if their condition is caused by a supplement they take or by the lack of supplements. “[We] have to be aware of all of the positive and negative data that’s out there and what I call ‘pseudo’ data, which is blogging, Instagram influencers, etc.,” Dr. Goldenberg says. Guests: Gary Goldenberg, MD (Icahn School of Medicine at Mount Sinai, New York, and Goldenberg Dermatology, PC, New York) Show notes by: Jason Orszt, Melissa Sears, Elizabeth Mechcatie For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgeDerm Gary Goldenberg on Twitter: @Goldenberg_Derm
JAMA Dermatology Author Interviews: Covering research on the skin, its diseases, and their treatment
Interview with Aimee S. Payne, MD, PhD, author of Factors Associated With Complete Remission After Rituximab Therapy for Pemphigus
Interview with Aimee S. Payne, MD, PhD, author of Factors Associated With Complete Remission After Rituximab Therapy for Pemphigus
20 March 2018: Erin Foster interviews Aimee Payne on precision medicine for pemphigus therapy
26 February 2013: Join presenter Dr. Robert Dellavalle as he speaks with Dr. John R. Stanley from the University of Pennsylvania about desmoglein as a target for pemphigus and other skin disease therapies, which has illuminated the pathophysiology of seemingly unrelated diseases.
In this edition of the JDD Podcast “Ask an Investigator,” host Dr. Adam Friedman speaks with Dr. Animesh Sinha, the Rita M. & Ralph T. Behling Professor and Chair of...
Succes I Veterinær Praksis Podcast - Sammen om at blive bedre
Se noter og links på sivp.dk/9 Leishmania hos hunde Eva fortæller at Leishmania præsenterer sig næsten altid med hudproblemer om symmestrisk alopeci og noduli. Der kan også ses vægttab, nedstemt humør, tegn på begyndende nyresvigt og nogle gange øget blødningstendens. Promastigoter udvikles i sandfluen. Disse injiceres i værten når sandfluen bider. Her optages promastigoterne af makrofager og spredes i kroppen. Inkubationstiden er 1 måned op til 7 år. Intracellulære amastogoter (non-flagellat-form) giver kutane læsion hvorfra sandfluer re-inficeres. Den intracellulære form kan desuden inducere et kraftigt immunrespons der resulterer i glomerulonefritis og polyartritis på grund af udviklingen af immunkomplekser. Anamnesen Indeholder næsten altid information om udlandsrejse inden for 7 år eller om oprindelse af Syd- og mellemeuropa. Cases er set i Mellemeuropa (bl.a. Tyskland) hos hunde, der ikke har været ude og rejse. Klinisk undersøgelse Eva forklarer at vi klassisk vil se hudproblemer og tegn på systemiske lidelse. For en stor del af patienterne vil det være lymadenopati og forstørret milt og evt. forstørret lever Paraklinisk undersøgelse Antistof kan måles i serum med høj specificitet og sensitivitet. Amastigote kan ses ved direkte mikroskopi af lymfeknude- og knoglemarvsaspirat og ved direkte hudaftryk. Dette giver en definitiv diagnose. Eva beskriver at paraklinisk ses ofte: Azotæmi (øget crea og urea) og polyclonal hyperglobulinæmi (altså fra forskellelige celleliner) Proteinuri kan forekomme i en ren urinprøve uden aktivt sediment og Urin/Protein-Creatin-ratio vil ofte være større end 0,5. Differentialdiagnoser Immunmedierede sygdomme som Pemphigus foliaceus og SLE er differentialdiagnoser. Det er neoplasi som Lymfoma Multipelt myelom. Behandling I følgelige Eva kan Leishmania behandles med Allopurinol, der er det mest effektive pt. Forebyggelse af infektion ved at forhindre sandfluers bid er eneste medicinske mulighed for forebyggelse. Til dette bruges rappellerende medicin som Permethrin (Bayvantic Vet eller Effitix) Desuden bør hunde holdes inde og under flue-/myggenet om natten. Hunde med nyresvigt bør monitoreres herfor.
In 1996, Francesca Tenconi was diagnosed with Pemphigus Foliaceous, a life-threatening auto-immune based skin disease. She and the other children she met while receiving medical care felt isolated and had no organization focusing on the unique challenges faced by children with such visual diseases. On her 16th birthday in 2000, Tenconi established the Children's Skin Disease Foundation to raise funds for research for the treatment and potential cure of several skin diseases that affect children. In 2001 Tenconi established Camp Wonder as a summer camp for children who suffer from skin diseases in order to give them the sense of normalcy and the normal experiences that children have during the summer.
Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 06/06
Desmosomen sind spezialisierte Haftstrukturen, die die Stabilisierung des Zellverbundes gegenüber Zug- und Scherkräften gewährleisten. Dazu binden desmosomale Cadherine extrazellulär an Haftmoleküle benachbarter Zellen und sind intrazellulär unter anderem über Desmoplakin (DP) und Plakoglobin (PG) an Keratinfilamenten verankert. Insbesondere für das desmosomale Cadherin Desmoglein 3 (Dsg3), das sowohl innerhalb als auch außerhalb der Desmosomen vorkommt, wurde eine wichtige Bedeutung als Adhäsionsprotein in Keratinozyten nachgewiesen. Trotz ihrer Funktion, Widerstand gegen hohe mechanische Belastungen zu vermitteln, sind Desmosomen dynamische Strukturen, die einem stetigen Umbau unterliegen. Die Notwendigkeit einer genauen Regulierung des desmosomalen Auf- und Abbaus wird durch das Vorkommen zahlreicher vererbbarer und autoimmuner Erkrankungen unterstrichen. In der vorliegenden Arbeit wurden Mechanismen, die der geordneten Assemblierung der Desmosomen und der Disassemblierung nach Störung der desmosomalen Zell-Zell-Haftung unterliegen, untersucht. Im ersten Teil der vorliegenden Studien standen die Vorgänge der Desmosomenbildung in humanen Keratinozyten im Fokus. Adhärenskontakte und deren Zusammenwirken mit Actinfilamenten spielen eine wichtige Rolle in der Ausbildung der Desmosomen. Für die Actin-Bindeproteine Adducin und Cortactin wurde durch siRNA-Interferenzstudien eine essentielle Funktion für die Vermittlung der desmosomalen Zell-Zell-Haftung nachgewiesen. Die siRNA-induzierte Depletion von Adducin verursachte eine Reduktion der zytoskelettal-gebundenen Dsg3-Moleküle, was mit einer reduzierten Membranmobiltät korrelierte. Für Cortactin wurde eine direkte Interaktion mit Dsg3 mittels zweier unabhängiger molekularbiologischer Methoden nachgewiesen. Dies deutet auf eine direkte Rolle des Cortactins in der Regulierung der Desmosomen hin. Die siRNA-induzierte Depletion von E-Cadherin führte zum Verlust der membranständigen Lokalisation von Dsg3 und zu einer verminderten Verankerung der Dsg3-Moleküle innerhalb der zytoskelettalen Proteinfraktion. Es wurde ein Signalkomplex aus extradesmosomalen Dsg3, E-Cadherin und der Tyrosinkinase Src identifiziert, dessen Stabilität durch Src reguliert wurde. Hierbei wurden Dsg3 und E-Cadherin an Tyrosinresten durch Src phosphoryliert, deren Aktivität sowohl für die Inkorporation von Dsg3 in die Desmosomen als auch für die Reifung der Desmosomen zu stabilen Haftkontakten essentiell war. Im zweiten Teil der vorliegenden Arbeit wurden die Prozesse der desmosomalen Disassemblierung nach Inkubation mit Pemphigus vulgaris-Autoantikörpern (PV-IgG) analysiert.PV ist eine etablierte Modellerkrankung zur Untersuchung der Desmosomen-vermittelten Zelladhäsion in Keratinozyten. Die Bindung der gegen Dsg1 und Dsg3 gerichteten PV-IgGs induziert eine Reduktion der Dsg3-Proteinmengen und eine Aktivierung verschiedener Signalwege, u.a. von RhoA und PKC. Da diese Signalwege ebenfalls Adducin regulieren und PV-IgGs eine Umorganisierung des Actin-Zytoskeletts verursachen, die durch exogene Aktivierung von RhoA verhindert wird, wurde das Zusammenspiel von PV-IgGs, RhoA und Adducin untersucht. Die protektive Wirkung der RhoA-Aktivierung auf die Zell-Zell-Haftung und die Verteilung von Dsg3 nach Applikation der PV-IgGs war sowohl von der Expression als auch von der Phosphorylierung von Adducin an Serin726 abhängig. Interessanterweise verursachten PV-IgGs über den Ca2+-Einstrom und über PKC, unabhangig von RhoA, eine schnelle Phosphorylierung von Adducin an Serin726. Die durch den Ca2+-Einstrom- und PKC-vermittelte Phosphorylierung von Adducin könnte somit einen Rettungsmechanismus der Keratinozyten darstellen, der in Reaktion auf die PV-IgG-Bindung einsetzt und die desmosomale Assemblierung induziert. Ferner wurde die reduzierte Verankerung der Keratinfilamente an Desmosomen, ein weiteres Merkmal der PV-Pathogenese, mit der Aktivität von PKC korreliert. Keratinfilamente, die einer dynamischen Regulierung durch p38MAPK unterliegen, lösen sich in Reaktion auf PV-IgGs von den Desmosomen und akkumulieren perinukleär. Dieses Phänomen der Zytokeratin-Retraktion wurde durch Inkubation mit Tandempeptid (TP), das die Transinteraktion von Desmogleinen stärkt, verhindert. Zusammenfassend liefern die in dieser Arbeit gewonnenen Daten neue Erkenntnisse über die Mechanismen des desmosomalen Umsatzes. Adducin und E-Cadherin nehmen eine essentielle Rolle in der Ausbildung und Aufrechterhaltung der desmosomalen Haftstrukturen ein. Untersuchungen der pathogenen Effekte der PV-IgGs unterstreichen die hohe Relevanz eines intakten Actin- und Keratin-Stützgerüsts für die interzelluläre Haftung von Keratinozyten. Diese Befunde könnten in Zukunft auch von medizinischer Relevanz für die Therapie von Pemphigus-Patienten sein.
Travis left behind his wife and two young children who can really use all of our help, which is why we are holding this telethon. To donate to the family please follow this link to the GoFundMe campaign. August 12th, 2013 the US lost a devoted father, inspired technology developer, teacher, husband, friend, entrepreneur and highly decorated United States Marine to a battle with an illness he brought back with him from his tour in Gulf War I but that lay dormant until last year when it turned his own immune system against him and developed into the flesh eating disease 'Pemphigus.' Although it appeared that recent treatments might have had him on the road to recovery, he had been out of the VA hospital for just a few weeks when the strain the illness had had on his body led to a sudden and fatal heart attack that claimed his life at 42. Travis' story is devastating to his friends and his family, but surprisingly perhaps more so even for the country that he fought and eventually died for. Travis was an innovator. He was an inventor, a self-styled computer 'ninja' who worked with some of the brightest minds in internet technologies and automated marketing to develop tools and concepts that are still years ahead of the market. The loss of inspired innovation to the country right now during our time of economic crisis is particularly poignant. On today's show we are going to celebrate the life of a man whose sense of humour was second only to his sense of family and of country, and we'll do so by sharing the memories of his friends and family and anyone who has a fond rememberance. We also hope to have some doctors on who can talk about Pemphigus, the illness that took Travis and several other veterans from us, to see what can be done to advance and improve out treatment of this ghastly disease.
Travis left behind his wife and two young children who can really use all of our help, which is why we are holding this telethon. To donate to the family please follow this link to the GoFundMe campaign. August 12th, 2013 the US lost a devoted father, inspired technology developer, teacher, husband, friend, entrepreneur and highly decorated United States Marine to a battle with an illness he brought back with him from his tour in Gulf War I but that lay dormant until last year when it turned his own immune system against him and developed into the flesh eating disease 'Pemphigus.' Although it appeared that recent treatments might have had him on the road to recovery, he had been out of the VA hospital for just a few weeks when the strain the illness had had on his body led to a sudden and fatal heart attack that claimed his life at 42. Travis' story is devastating to his friends and his family, but surprisingly perhaps more so even for the country that he fought and eventually died for. Travis was an innovator. He was an inventor, a self-styled computer 'ninja' who worked with some of the brightest minds in internet technologies and automated marketing to develop tools and concepts that are still years ahead of the market. The loss of inspired innovation to the country right now during our time of economic crisis is particularly poignant. On today's show we are going to celebrate the life of a man whose sense of humour was second only to his sense of family and of country, and we'll do so by sharing the memories of his friends and family and anyone who has a fond rememberance. We also hope to have some doctors on who can talk about Pemphigus, the illness that took Travis and several other veterans from us, to see what can be done to advance and improve out treatment of this ghastly disease.
Wed, 09 May 2012 14:32:36 GMT http://saveyourskin.ch/podcast/EN/1.2.5.Pemphigus_vulgaris.mp4 Prof. Dr. Dr. h. c. Günter Burg, MD Zürich & Prof. Dr. Walter Burgdorf, MD 2013-03-10T14:32:37Z Prof. Dr. Dr. h. c. Günter Burg, MD Zürich & Prof. Dr. Walter Burgdorf, MD no
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 08/19
Thu, 3 Apr 2008 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/8334/ https://edoc.ub.uni-muenchen.de/8334/1/Martin_Stefanie_E.pdf Martin, Stefanie Elisabeth
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