Podcasts about all maladies

Director of "Caregiving",Chris Durrance joins host Ron Aaron and co-host Carol Zernial to talk about the upcoming PBS series "Caregiving" on this edition of Caregiver SOS. About Chris Chris Durrance is an award-winning documentary filmmaker, who is director of the forthcoming PBS series, "Caregiving." Durrance worked on more than a dozen films for FRONTLINE, three presidential biographies and an independent documentary on gerrymandering – Slay the Dragon – which premiered at the Tribeca Film Festival. He is the winner of a Peabody, two Emmys, a duPont-Columbia silver baton and an Overseas Press Club award. Recently, Durrance directed two major PBS series on science and medicine – Cancer: The Emperor of All Maladies and The Gene. He is the founder of Seven One Eight Studios. Hosts Ron Aaron and Carol Zernial, and their guests talk about Caregiving and how to best cope with the stresses associated with it. Learn about "Caregiver SOS" and the "Teleconnection Hotline" programs.See omnystudio.com/listener for privacy information.

Tom Chiodo joins host Ron Aaron and co-host Carol Zernial to talk about "Caregiving", a documentary coming to PBS with executive producer Bradley Cooper on this edition of Caregiver SOS. About Tom Executive producer, Special Projects in National Productions at WETA, the flagship PBS station in Washington, DC. Documentaries: Ken Burns’ Hiding in Plain Sight: Youth Mental Illness; Emmy-nominated The Gene: An Intimate History; DuPont Columbia Award & Emmy-nominated Cancer: Emperor of All Maladies. Executive producer of upcoming projects: Caregiving (June 2025), Remote Chance: Health Care in Rural America, Defeating Dementia, Climate Kitchen. Held senior positions: Entertainment Industry Foundation, Rubenstein Assoc., U.S. Dept. HHS, Mass. Dept. Public Health. Co-author “Home Care for Respirator Dependent Children” New England Journal of Medicine. Contributing writer Forbes.com Hosts Ron Aaron and Carol Zernial, and their guests talk about Caregiving and how to best cope with the stresses associated with it. Learn about "Caregiver SOS" and the "Teleconnection Hotline" programs.See omnystudio.com/listener for privacy information.

Brea and Mallory tick off another box on the 2025 Reading Glasses Challenge - read a science book! Plus, they solve a problem about getting a library book signed, and recommend YA books that deal with social justice. Email us at readingglassespodcast at gmail dot com!Reading Glasses MerchRecommendations StoreSponsors -Aura Frameswww.auraframes.comCODE: GLASSESZocDocwww.zocdoc.com/GLASSESLinks -Reading Glasses Facebook GroupReading Glasses Goodreads GroupAmazon Wish ListNewsletterLibro.fmTo join our Discord channel, email us proof of your Reading-Glasses-supporting Maximum Fun membership!www.maximumfun.org/joinSpring ReadathonSunday May 18thBooks Mentioned - The Centre by Ayesha Manazir SiddiqiThe Fair Botanists by Sara SheridanEverything is Tuberculosis by John GreenThe Emperor of All Maladies by Siddhartha MukherjeeThe Hate U Give by Angie ThomasThe Attack of the Black Rectangles by A.S. King

Dr. Siddhartha Mukherjee became famous with his epic nonfiction book about cancer, “The Emperor of All Maladies.” The book shows that if there's one constant in cancer research, it's that it's always changing. On this episode of “The C-Word: Stories of Cancer,” Shirley talks to Dr. Mukherjee about how his time living and working in Boston changed him as a doctor. They discuss the hopeful progress we've made in curing cancer - and the challenges that persist. Email us at saymore@globe.com.

Jason Howell and Jeff Jarvis dive deep into AI's creative impact with Lev Manovich, author of Artificial Aesthetics, analyze the implications of DeepSeek's cost-effective AI development, and explore OpenAI's Project Operator for automated web browsing. Support the show on Patreon! http://patreon.com/aiinsideshow Subscribe to the new YouTube channel! http://www.youtube.com/@aiinsideshow Note: Time codes subject to change depending on dynamic ad insertion by the distributor. 0:01:43 - INTERVIEW Interview with Lev Manovich, professor of computer science at CUNY and co-author of "Artificial Aesthetics" Discussion of AI's impact on creativity and artistic expression Exploration of how AI tools serve as both collaborators and adversaries in artistic creation Deep dive into the concept of AI aesthetics versus traditional artistic concepts NEWS 0:39:05 - DeepSeek... the Seekening! DeepSeek reaches No. 1 on US Play Store DeepSeek displaces ChatGPT as the App Store's top app Nvidia drops nearly 17% as China's cheaper AI model DeepSeek sparks global tech sell-off OpenAI says it has evidence China's DeepSeek used its model to train competitor Viral AI company DeepSeek releases new image model family Jeff's take 0:50:02 - OpenAI launches ChatGPT Gov for U.S. government agencies 0:51:37 - OpenAI: Introducing Operator 0:58:07 - Reid Hoffman Raises $24.6 Million for AI Cancer-Research Startup with ‘The Emperor of All Maladies' author Siddhartha Mukherjee 0:59:35 - Reid Hoffman: We can make AI work for us 1:05:25 - New glowing molecule, invented by AI, would have taken 500 million years to evolve in nature, scientists say Learn more about your ad choices. Visit megaphone.fm/adchoices

In this inaugural special live episode of Parola Progetto, recorded at Salotto in Brooklyn and presented in English, we are honored to host Paola Antonelli.As the Senior Curator of the Department of Architecture and Design at The Museum of Modern Art (MoMA) and the museum's Director of Research and Development, Antonelli brings a wealth of experience and insight. During our conversation, we delve into her distinguished career at MoMA, discussing the dynamics of success and rejection, the evolving role of curating, and how museums function as research and development hubs for society. Antonelli offers her perspectives on technology, artificial intelligence, and the future of design, highlighting the critical importance of thoughtful analysis and cultural awareness in these fields.The links of this episode:Salotto, a hub for cultural research and production run by NYC-based Italian creative professionals https://salotto.nycDesign Emergency, curated by Alice Rawsthorn and Paola Antonelli https://www.instagram.com/design.emergencyMoMA R&D Salons http://momarnd.moma.org/salons“Broken Nature: Design Takes on Human Survival”, curated by Paola Antonelli at La Triennale di Milano in 2019 https://triennale.org/en/events/broken-nature “Planet City” by Liam Young https://www.moma.org/collection/works/450744 “Pirouette. Experiments and Turning Points in Design” curated by Paola Antonelli at MoMA in 2025https://www.moma.org/calendar/exhibitions/5756“ITEMS. Is Fashion Modern?”, curated by Paola Antonelli at MoMA in 2018https://www.moma.org/calendar/exhibitions/1638 "The Emperor of All Maladies: A Biography of Cancer" by Siddhartha Mukherjee https://en.wikipedia.org/wiki/The_Emperor_of_All_Maladies  

Dr. Dominic Brady, an award-winning plastic surgeon, was diagnosed with incurable Multiple Myeloma in 2017. Determined to augment his conventional treatment naturally, he did a deep dive into extensive cancer and nutrition research. As a result, Dr. Brady adopted a whole food, plant-based diet, regular exercise, and targeted supplements. His remarkable remission has surprised his oncologist, and he's now on an extremely low dose of immunomodulators, with a goal to completely eliminate medication—something previously thought impossible for myeloma patients.  In this episode, Dr. Brady shares his journey from being a cancer patient to helping others navigate their own cancer treatments. He highlights the critical role of nutrition, which is largely neglected in medical training. Inspired by Dr. Michael Gregor's book How Not to Die, Dr. Brady embraced a diverse, plant-based diet to support his microbiome, aiming for 30 different foods per week. He also discusses fasting, calorie restriction during chemotherapy, and the power of fiber and healthy fats. Dr. Brady covers various health practices like infrared saunas, detoxification, and water purification to support healing.  For more on Dr. Brady's approach and to make an appointment, visit his website.  Find Dr Dominic Brady at: Website: www.naturalinsightsintocancer.com Instagram: @cancerveggiedoc Book – Beat Back Cancer Naturally: https://a.co/d/2pJj6La  Discussed on the PODCAST: Book - How Not to Die – Dr. Michael Gregor - https://a.co/d/eSZJz4M Book - The Anti Cancer Diet – Dr. David Servan-Schreiber - https://a.co/d/iTOfqUh The American Gut Project - https://microsetta.ucsd.edu/  Book - The Starch Solution – John McDougal - https://a.co/d/1EJmnHi Book – The China Study – Dr. T. Colin Campbell - https://a.co/d/cNgReRO Fasting – Dr. Valter Longo - https://www.valterlongo.com/ Documentary - Blue Zones https://www.bluezones.com/ Simon Hill interview Resident at Loma Linda University – 14% is plant based products –  Engine 2 diet – Rip Esselstyne Recipes - https://a.co/d/3S9UBhj Lucini Olive Oil - https://www.californiaoliveranch.com/ Consumer Lab - www.consumerlab.com  Drugs Check – www.Drugs.com Book - Empire of All Maladies - https://a.co/d/ebMm9z0   Learn More: Are you a therapist, health coach, nutritionist or health care worker? Learn more about our 6-Month Training course to be a certified Metabolic Nutrition & Detox Instructor!: -  https://bit.ly/3YgNH6F   Book onto one of our Eat Real to Heal Retreats - https://bit.ly/3U3Dvfg   Watch our award winning short documentary Grounded In My Roots - https://www.groundedinmyroots.com/  Find out more about our Charity- Sea to Sky Thrivers - https://bit.ly/S2STS  Want to know more about Nicolette's Green Moustache Café's https://bit.ly/GMCafeW  Sign up for the Eat Real to Heal Online Course - https://www.richerhealth.ca/  Buy the Eat Real to Heal Book here: https://bit.ly/4b7mzLa 

Show SummaryOn today's episode, we feature Tom Chiodo, Executive Producer of Special Projects, National Productions for WETA, he flagship PBS station in Washington DC. We discuss the upcoming PBS Documentary, Caregiving, which will examine both systematic issues within the care system as well as tell personal stories of people who care for loved ones.    Provide FeedbackAs a dedicated member of the audience, we would like to hear from you about the show. Please take a few minutes to share your thoughts about the show in this short feedback survey. By doing so, you will be entered to receive a signed copy of one of our host's three books on military and veteran mental health. About Today's GuestsTom Chiodo is the executive producer of Special Projects National Productions for WETA (Washington Educational Telecommunications Association), the flagship PBS station in Washington DC. WETA develops primetime documentary films and original digital content, accompanied by national impact and engagement campaigns, across 330+ PBS stations in more than 150 markets. Recent public media projects: Ken Burns presents Hiding in Plain Sight: Youth Mental Illness, a film by Erik Ewers and Christopher Loren Ewers (2022); Emmy-nominated documentary Ken Burns presents The Gene: An Intimate History(2020); Rethinking High School with Soledad O'Brien Town Hall at Howard University (2016); DuPont Columbia Award & Emmy-nominated documentary Cancer: The Emperor of All Maladies (2015). Current documentary projects in development/production: Caregiving; Hiding in Plain Sight: Adult Mental Illness;Remote Chance: Health Care in Rural America; Defeating Dementia; and Mighty Real: Out and Proud in America. Thirty years' experience in the media, communications, television and entertainment industry. Former SVP Development Entertainment Industry Foundation creating programs and funding for national initiatives in health care, volunteerism, childhood hunger and education. Tom has held senior positions at Rubenstein Associates, U.S. Department of Health & Human Services, Massachusetts Department of Public Health & State Office for Children. Former clients: HBO; AMC; TIME, Inc.; Wenner Media; Talk Miramax Books; Columbia University; Albert Einstein College of Medicine; Major League Baseball; Dance Theater of Harlem; The Apollo Theatre; Al Roker Entertainment, Inc.; The Tony Awards; Tribeca Film Festival; ABC's Good Morning America; Stand Up to Cancer; and Chances for Children.Board memberships: Fenway Community Health Center (Boston), Professional Performing Arts High School (NYC), Heart Gallery New York. National Academy of Television Arts & Sciences judge for the 44th Annual News & Documentary Emmy Awards. Tom is a published playwright, and co-author of “Home Care for Respirator Dependent Children” New England Journal of Medicine.  Links Mentioned in this Episode Wellbeings Web SiteCaregiving Documentary WebsiteCaregiving TrailerPsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is the Military Caregiver Recognition Award and Digital Resource Binder. PsychArmor is dedicated to providing education, resources, and strategies for those who provide care for our nation's wounded, ill and injured military service members and Veterans. The caregiving journey can be challenging — we're here to provide support. Thanks to the generosity of The USAA Foundation, and in collaboration with the Elizabeth Dole Foundation, we are pleased to offer the newly digitized Military Caregiver Recognition Award Program. Upon completion of the four PsychArmor courses included in this program and registration for the Elizabeth Dole Foundation's Hidden Heroes Caregiver Community, you will receive the Military Caregiver Recognition Award and Badge. You can see find the resource here:    https://learn.psycharmor.org/courses/military-caregiver-award Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on TwitterPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

Jeff and Rebecca talk about what a dad book is, what it isn't, and what it could be. Then, they give some recommendations that best represent the Dad Book 2.0. Subscribe to the podcast via RSS, Apple Podcasts, and Spotify. For more industry news, sign up for our Today in Books daily newsletter! This content contains affiliate links. When you buy through these links, we may earn an affiliate commission. Discussed in this episode: TBR! For Father's Day! Or anyone on any day! The Book Riot Podcast Patreon Grit by Angela Duckworth Grunt by Mary Roach Assassination Vacation by Sarah Vowell The Emperor of All Maladies by Siddhartha Mukherjee The Structure of Scientific Revolutions by Thomas S. Kuhn Moneyball by Michael Lewis Attica Locke S.A. Cosby Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode Description: Elliot Hershberg, a computational biologist, writer, and investor, joins Karl and Erum to explore the fascinating intersection of technology, biology, and philosophy. ​They explore the power of technology-based newsletters, the economics of fermentation, the role of AI in biology, and the future of biotech. The conversation raises thought-provoking questions about data reliability in AI-driven platforms and the need for cautious optimism in embracing new technologies. With insights into the minds of VCs and the potential implications of building a sentient AI, this episode offers a captivating glimpse into the exciting advancements and possibilities in the world of biotech! Grow Everything brings the bioeconomy to life. Hosts Karl Schmieder and Erum Azeez Khan share stories and interview the leaders and influencers changing the world by growing everything. Biology is the oldest technology. And it can be engineered. What are we growing? Learn more at ⁠⁠⁠⁠⁠⁠⁠⁠⁠www.messaginglab.com/groweverything⁠⁠⁠⁠⁠⁠⁠⁠⁠ Chapters: 00:00:00 - Synbiobeta Week: The Pulse of Biotech Innovation 00:01:12 - Microbiome Frontiers: From Netflix Documentaries to Real-World Applications 00:04:27 - Algae Chronicles: A Dive into Nature's Ingenious Endosymbionts 00:06:18 - The ChatGPT Phenomenon in Biotech: Conversing with Elliot Hirschberg 00:08:57 - Elliot Hershberg: Penning the Path from Literature to Biotech Breakthroughs 00:11:42 - Navigating the Biotech Labyrinth: Unraveling Complexities 00:15:26 - Biotech Ethos: Pondering the Universe Through a Biological Lens 00:17:58 - Elliot's Odyssey: Crafting 'Not Boring' Narratives in Biotech Finance 00:21:07 - The Biotech Think Tank: Cultivating Ideas 00:24:18 - BioTech Crossroads: Envisioning the Fusion of Life Sciences and Tech 00:27:28 - Quantum Biology: Unveiling the Microscopic Mysteries 00:29:31 - Machine Learning: The New Catalyst in Biological Discovery 00:31:31 - Blueprint for Biotech Trailblazers: Nurturing Innovation 00:32:52 - Venture Capital Visions: Sowing Seeds in Fertile Biotech Grounds 00:35:37 - Newsletters: The DNA of Biotech Knowledge Sharing 00:37:43 - Biomanufacturing Horizons: Shaping the Fabric of Future Production 00:42:38 - AI: The New Author and Architect in Biotech 00:45:39 - Biotech Forecasts: Charting the Uncharted 00:51:06 - Biotech Chronicles: Penning the Progress and Profits Episode Links: Not Boring Capital (link) Elliot Hershberg on LinkedIn The Century of Biology (link) Atomic AI (link) The Emperor of All Maladies by Siddhartha Mukherjee  (link) The Gene: An Intimate History by Siddhartha Mukherjee (link) The Song of the Cell by Siddhartha Mukherjee (link) Genentech: The Beginnings of Biotech by Sally Smith Hughes (link) For Blood and Money: Billionaires, Biotech, and the Quest for a Blockbuster Drug by Nathan Vardi (link) Molecular Biology Of The Cell by Bruce Alberts et al (link) Get $300 off ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Synbiobeta tickets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (May 6-9 in San Jose, CA) using promo code: Grow Everything Topics Covered:  colors, textile dyes, fabrics, fashion, bioreactors, synthetic biology, synbio, bioengineering, organism engineering, microbiology Have a question or comment? Message us here: Text or Call (804) 505-5553 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Twitter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Youtube⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ / ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠GrowEverything website⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Email: groweverything@messaginglab.com Support here: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Patreon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Music by: Nihilore Production by: Amplafy Media --- Send in a voice message: https://podcasters.spotify.com/pod/show/messaginglab/message

Guest: Dave Hallett Cancer, called the “Emperor of All Maladies” has been a formidable adversary of mankind since time immemorial. With its multitude of forms and elusive nature, cancer presents a daunting challenge for drug discovery. However, AI offers a

Poisoned Ground: The Tragedy at Love Canal tells the dramatic and inspiring story of the ordinary women who fought against overwhelming odds for the health and safety of their families. In the late 1970s, residents of Love Canal, a working-class neighborhood in Niagara Falls, New York, discovered that their homes, schools and playgrounds were built on top of a former chemical waste dump, which was now leaking toxic substances and wreaking havoc on their health. Through interviews with many of the extraordinary housewives turned activists, the film shows how they effectively challenged those in power, forced America to reckon with the human cost of unregulated industry, and created a grassroots movement that galvanized the landmark Superfund Bill. Director / Producer Jamila Ephron (Cancer: The Emperor of All Maladies) joins us for a conversation on her detailed look into the incredible story of Niagara Falls, developer and con man William T. Love, hydro-electric power, Hooker Chemical, birth defects, cancer, miscarriages, Lois Gibbs, empowered woman, Griffon Manor, the taking of “hostages”, President Jimmy Carter, New York Governor Hugh Carey, establishment of the EPA and 22,000 tons of toxic chemicals under the feet of an unsuspecting community. Poisoned Ground: The Tragedy at Love Canal premieres Monday, April 22, 2024, 9:00–11:00 p.m. ET (check local listings) on American Experience on PBS, PBS.org and the PBS App. pbs.org/wgbh/americanexperience/films/poisoned-ground

Siddhartha Mukherjee is a Professor at Columbia University, oncologist, and extraordinary author of Emperor of All Maladies (which was awarded a Pulitzer Prize), The Gene, and The Song of the Cell, along with outstanding pieces in the New Yorker. He is one of the top thought leaders in medicine of our era. “I have begun to imagine, think about what it would be to be a digital human..”—Sid MukherjeeEric Topol (00:06):Well, hello, this is Eric Topol with Ground Truths, and I am delighted to have my friend Sid Mukherjee, to have a conversation about all sorts of interesting things. Sid, his most recent book, SONG OF THE CELL is extraordinary. And I understand, Sid, you're working on another book that may be cell related. Is that right?Sid Mukherjee  (00:30):Eric, it's not cell related, I would say, but it's AI and death related, and it covers, broadly speaking, it covers AI, longevity and death and memory —topics that I think are universal, but also particularly medicine.Eric Topol (00:57):Well, good, and we'll get into that. I had somehow someone steered me that your next book was going to be something building on the last one, but that sounds even more interesting. You're going in another direction. You've covered cancer gene cells, so I think covering this new topic is of particularly interest. So let's get into the AI story and maybe we'll start off with your views on the healthcare side. Where do you think this is headed now?A.I. and Drug DiscoverySid Mukherjee  (01:29):So I think Eric, there are two very broad ways of dividing where AI can enter healthcare, and there may be more, I'm just going to give you two, but there may be more. One is on what I would call the deep science aspect of it, and by that I mean AI-based drug discovery, AI-based antibody discovery, AI-based modeling. All of which use AI tools but are using tools that have to do with machine learning, but may have to do less directly with the kind of large language models. These tools have been in development for a long time. You and I are familiar with them. They are tools. Very simply put, you can imagine that the docking of a drug to a protein, so imagine every drug, every medicine as a small spaceship that docks onto a large spaceship, the large spaceship being the target.(02:57):So if you think of it that way, there are fundamental rules. If anyone's watched Star Wars or any of these sci-fi films, there are fundamental rules by which that govern the way that the small spaceship in this case, a molecule like aspirin fits into a pocket of its target, and those are principles that are determined entirely by chemistry and physics, but they can be taught, you can learn what kind of spaceship or molecule is likely to fit into what kind of pocket of the mothership, in this case, the target. And if they can be learned, they're amenable to AI-based discovery.Eric Topol (03:57):Right. Well, that's, isn't that what you'd call the fancy term structure-based discovery, where you're using such tools like what AlphaFold2 for proteins and then eventually for antibodies, small molecules, et cetera, that you can really rev up the whole discovery of new molecules, right?Sid Mukherjee  (04:21):That's correct, and that's one of the efforts that I'm very heavily involved in. We have created proprietary algorithms that allow us to enable this. Ultimately, of course, there has to be a method by which you start from these AI based methods, then move to physical real chemistry, then move to real biology, then move to obviously human biology and ultimately to human studies. It's a long process, but it's an incredibly fruitful process.Eric Topol (04:57):Well, yeah, as an example that recently we had Jim Collins on the podcast and he talked about the first new drug class of antibiotics in two decades that bind to staph aureus methicillin resistant, and now in clinical trials. So it's happening. There's 20 AI drugs in clinical trials out there.Sid Mukherjee  (05:18):It's bound to happen. It is an unstoppable bound to happen systematology of drug discovery. This is just bound to happen. It is unstoppable. There are kinks in it in the road, but those will be ironed out, but it's bound to happen.(05:41):So that's on the very discovery oriented end, which is more related to learning algorithms that have to do with AI and less to do with what we see in day-to-day life, the ChatGPT kind of day-to-day life of the world. On the very other end of the spectrum, just to move along on the very other end of the spectrum are what I would call patient informatics. So by patient informatics, I mean questions like who responds to a particular drug? What genes do they have? What environment are they in? Have they had other drug interactions in the past? What is it about their medical record that will allow us to understand better why or why they're not responding to a medicine?(06:51):Those are also AI, can also be really powered by AI, but are much more dependent and much more sensitive to our understanding of these current models, the large language models. So just to give you an example, let's say you wanted to enroll a clinical trial for patients with diabetes to take a new drug. You could go into the electronic medical record, which right now is a text file, and ask the question, have they or have they not responded to the standard agents? And what has their response been? Should they be on glucose monitoring? How bad is their diabetes based on some laboratory parameters, et cetera, et cetera. So that's a very different information rich, electronic medical record rich mechanism to understand how to develop medicines. One lies, the first lies way in the discovery end of the spectrum. The second lies way in the clinical trials and human drug exposure end of the spectrum. And of course, there are things in the middle that I haven't iterated, but those are the two really broad categories where one can imagine AI making a difference and to be fair through various efforts, I'm working on both of those, the two end spectrum.A.I. and CancerEric Topol (08:34):Well, let's drill down a bit more on the person individual informatics for a moment, since you're an oncologist, and the way we screen for cancer today is completely ridiculous by age only. But if you had a person's genome sequence, polygenic risk scores for cancers and all the other known data that, for example, the integrity of their immune system response, environmental exposures, which we'll talk about in a moment more, wouldn't we do far better for being able to identify high risk people and even preventing cancer in the future?Sid Mukherjee  (09:21):So I have no doubt whatsoever that more information that we can analyze using intelligent platforms. And I'm saying all of these words are relevant, more information analyzed through intelligent platforms. More information by itself is often useless. Intelligent platforms without information by themselves are often useless, but more information with intelligent platforms, that combination can be very useful. And so, one use case of that is just to give you one example, there are several patients, women who have a family history of breast cancer, but who have no mutations in the known single monogenic breast cancer risk genes, BRCA1, BRCA2, and a couple of others. Those patients can be at a high a risk of breast cancer as patients who have BRCA1 and BRCA2. It's just that their risk is spread out through not one gene but thousands of genes. And those patients, of course have to be monitored and their risk is high, and they need to understand what the risk is and how to manage it.(10:57):And that's where AI can, and first of all, informatics and then AI can play a big difference because we can understand how to manage those patients. They used to be called, this is kind of, I don't mean this lightly, but they used to be called BRCA3 because they didn't have BRCA1, they didn't have BRCA2, but they had a constellation of genes, not one, not two, but thousands of genes that would increase their risk of breast cancer just a little bit. I often describe these as nudge genes as opposed to shove genes. BRCA1 and BRCA2 are shoved genes. They shove you into having a high risk of breast cancer. But you can imagine that there are nudge genes as well in which they, in which a constellation of not one, not two, not three, but a thousand genetic variations, give a little push each one, a little push towards having a higher risk of breast cancer.(12:09):Now, the only way to find these nudge genes is by doing very clever informatic studies, some of which have been done in breast cancer, ovarian cancer, cardiovascular diseases, other diseases where you see these nudge effects, small effects of a single gene, but accumulated across a thousand, 2000, 3000 genes, an effect that's large enough that it's meaningful. And I think that we need to understand those. And once we understand them, I think we need to understand what to do with these patients. Do we screen them more assertively? Do we recommend therapies? You can get more aggressive, less aggressive, but of course that demands clinical trials and a deeper understanding of the biology of what happens.A.I. And LongevityEric Topol (13:10):Right, so your point about the cumulative effects of small variants, hundreds and hundreds of these variants being equivalent potentially, as we've seen across many diseases, it's really important and you're absolutely right about that. And I've been pushing for trying to get these polygenic risk scores into clinical routine use, and hopefully we're getting closer to that. And that's just as you say, just one layer of this information to add to the intelligence platform. Now, the next thing that you haven't yet touched on connecting the dots is, can AI and informatics be used to promote longevity?Sid Mukherjee  (13:55):Yeah, so that's a very interesting question. Let me attack that question in two ways. One biological and one digital. The biological one is to understand, again, the biological one has to do with informatics. So we could use AI so that, imagine that there are thousands, perhaps tens of thousands of variables. You happen to live on a Mediterranean island, you happen to walk five miles a day, you happen to have a particular diet, you happen to have a particular genetic makeup, you happen to have a particular immunological makeup, et cetera, et cetera, et cetera. All of those you happen to have, you happen to have, you happen to have. Now, if we could collect all of this data across hundreds of thousands of individuals, we'd need a system to deconvolute the data and ask the question, what is it about these 750,000 individuals that predicted longevity? Was it the fact that they walked five miles a day? Was it  their genetic makeup? Was it their diet? Was it their insulin level? Was it their, so you can imagine an n-dimensional diagram, as it were, and to deconvolute that n-dimensional diagram and to figure out what was the driving force of their longevity, you would need much more than conventional information analysis. You need AI.(15:58):So that's one direction that one could use. Again, informatics to figure out longevity. A second direction, completely independent of the first is to ask the question, what are the biological determinants of longevity in other animals? Is it insulin levels? Is it chronic? Is it the immune system? Is it the lack of, and we'll come back to this question, is it as you very well know, people with extreme longevity, the so-called supercentenarians. Interestingly, the supercentenarians don't generally die of cancer and heart disease, which are the two most common killers of people in their 70s and 80s in most countries of the western world. They die typically of what I would call regenerative failure. Their immune systems collapse. Their stem cells can't make enough skin, so they get skin infections, their skin collapses, they get bone defects, and they die of fractures. They get neurological defects, they die of neurodegenerative diseases and so forth. So they die of true degenerative diseases as opposed to cancer and heart disease, which have been the plagues of human biology since the beginning of time.(17:49):Again, I'm talking about the western world, of course, a different story with infectious diseases elsewhere. So a different way to approach the problem would be to say, what are the regenerative blockades that prevent regeneration at a biological level for these patients? And ask the question whether we can overcome these regenerative blockades using, again, the systems that I described before. What are they? What are the checkpoints? What are the mechanisms? And could we encourage the body to override those mechanisms? We still have to deal with heart disease and cancer, but once we had dealt with heart disease and cancer, we would have to ask the question. Okay, now we've dealt with those two things. What are the regenerative blockades that prevent people from having longevity once we've overcome those two big humps, heart disease and cancer?Eric Topol (19:00):Yeah, no, I think you're bringing up a really fascinating topic. And as you know, there's been many different ideas for how to achieve that, whether that's the senolytic drugs or getting rid of dead cells or using the transcription factors of cells instead of going into induced pluripotent stem cells, but rather to go to a rejuvenation of cells. Are you optimistic that eventually we're going to crack this case of better approach to regeneration?Sid Mukherjee  (19:33):Oh, I'm extremely optimistic. I'm optimistic, but I'm optimistic to a point. And that brings me to the third place, which is I'm optimistic to a point, which is that you conquer in some, hopefully you conquer a major part of heart disease and cancer, and now you're up against cellular regeneration. You then conquer cellular regeneration. And I don't know what the next problem is going to be. It's going to be some new hurdle. So I think there are two solutions to that hurdle. One solution is to say, okay, there's a new hurdle. We'll solve that new hurdle and it's bit by bit extending longevity year by year, by year by year as it were. But a completely second solution occurs to me, and here I'm going completely off script, Eric, which is what I do in my life.Going Off Script: Being A Digital Human(20:45):I have begun to imagine, think about what it would be to be a digital human and by a digital human I mean, it began with my father's death. My father passed away a few years ago, and I would sometimes enter a kind of psychic space, what I would call a psychomanteum, in which I would imagine myself asking him questions about critical moments in my life, make a critical decision. I would rely on my father to make that decision for me. He would give me advice. That advice had some stereotypical qualities about it. Think about this, think about that. My experience has been this. My life has been this. My life has been that. But of course, times change. And I began to wonder whether with the use of digital technologies and digital AI technologies in particular, what could create a simulacrum of a psychomanteum?(22:06):So in other words, your physical body would pass, but somehow your digital body, all the memories, the experiences, the learning, all of that, that you had, the emotional connections that you had formed in your lifetime would somehow remain and would remain in a kind of psychomanteum in which you could go into a room. And again, I'm not talking voodoo science here. I'm talking very particular ways of extracting information from a person's decision making, extracting information about a person's ideas about the word their sort of their schema, or as psychologists describe it, the schemata. So that in some universe, if my father downloaded passively or actively the kind of decision making, not the actual decisions, the form of decision making and the form of communication that he liked, that I could go back to him eternally. My grandchildren could go back to him eternally and ask the question, great grandpa, what would you do under these circumstances? And what's amazing about it is that this is not completely science fiction.Eric Topol (23:45):Not at all.Sid Mukherjee  (23:46):It is within the realms of reality in the sense of there's no digital limitation to it. The main limitation to it is information. So Eric Topol, you make decisions I would imagine with some kind of stereotypical wisdom, you have accumulated wisdom in your life. You think about things in a particular critical way. When you read a book, you read a book in a particular way, it's whatever it might be. And Eric Topol psychomanteum would be, I would go into a space and see you and ask you a question, Eric, you read this book, what did you think about it? You found this piece of evidence. Read this scientific paper. What do you think about it? And so forth.(24:49):So again, let me just go back to my first point, which is number one, I think that regenerative medicine will have a regenerative moment itself, and we will discover new medicines, new mechanisms by which we can extend lifespan. Number two, that will involve getting over two big humps that we have right now, cancer and heart disease. Hopefully we'll get over both of those at some point of time. And number three, that in parallel, we will find a way to create digital selves that even when our physical bodies decay and die, that we will have a sense of eternal longevity based on digital selves, which is accessible or readily accessible through AI mechanisms. Yeah, this spectrum, I think will change our ideas of what longevity means.The Environmental FactorsEric Topol (26:10):Well, I think your idea about the digital human and the brain and the decision making and that sort of thing is really well founded by the progress being made in the brain machine interface, as you know, with basically the mind is being digitized and you can get cells to talk, to speak to a person, and all sorts of things that are happening right now that are basically deconvoluting brain function at the cellular, even molecular neural level. So I don't think it's farfetched at all. I'm glad you went off script, Sid. That's great. Now this, I want to get back to something you brought up earlier because there are a lot of obstacles as you will acknowledge. And one of them is that we have in our environment horrible issues about pollution, about carcinogens, the focus of your recent New Yorker piece, plastics, microplastics, nanoplastics, now found in our arteries and brains and causing more, as we just recently saw, more heart attack, strokes and death, and of course the climate crisis. So with all this great science that we've just been discussing, our environment's going to hell, and I want to get your comments because you had a very insightful piece as always in the New Yorker in December about this, and I know you've been thinking about it, that the obstacles are getting worse to override the problems that we have today, don't you think?Sid Mukherjee  (27:55):So you're absolutely right. If we go down this path, we are going to go to hell in eye baskets. What we haven't discounted for is really decades, if not possibly a century of research that shows that there are certain kinds of inflammatory agents that cause both cancer, heart disease, and inflammation that have to do with their capacity to be so foreign to the human body that they're recognized as alien objects and so alien that our immune systems can't handle them. And essentially send off what I would call a five-bell alarm, saying that here's something that the immune system can't handle. It's beyond the capacity. And that five-bell alarm, as we now know, unfortunately, causes a systemic inflammatory response. And that systemic inflammatory response can potentiate heart disease, cancer, and maybe many other diseases that we don't know about because we haven't looked.Eric Topol (29:28):Absolutely.Sid Mukherjee  (29:29):So to connect this back to climate change, pollution is one of them. Air pollution is absolutely one of them. Microplastics, undegradable sort of forever plastics are one of them, or some of them. I think that there is no way around it except to really find a systematic way of assessing them. Look, it is wonderful to have new materials in the world. I'm wearing a jacket made out of God knows what, it's not cloth. I don't know what you are wearing, Eric, but it may not be cloth. These are great materials. This keeps the rain away. But on the other hand, it may be shedding something that I don't know. We need to find scientific ways of assessing the safety and the validity of some new materials that we bring into the world. And the way that we do that is to ask the question, is it inflammatory? Is there something that we are missing? Is there something about it that we should be thinking about that we haven't thought about?Eric Topol (31:02):Well, and to that end, you've been a very, I think, astute observer about diet as it relates to cancer. And we know similarly, as we just talked about with our environment, there's the issue of ultra-processed foods, and we've got big food, we got big plastics, big tobacco. I mean, we have all these counter forces to what the science is showing.Sid Mukherjee  (31:29):Too many bigs.Eric Topol (31:31):Yeah, yeah. But I guess the net of it is, Sid, if I get it right, you think that the progress we're making in science, and that includes the things we've talked about and genome editing and accelerated drug discovery, these sorts of programs, the informatics, the AI can override this chasing of our tail with basically unchecked issues that are, whether it's from our nutrition, our air, what we ingest and breathe, these are some serious problems.Preventing DiseasesSid Mukherjee  (32:06):No, I don't think that. I don't think that cancer and cardiovascular disease prevention, as you very well know, Eric, because you've been in the forefront of it, is a pyramid. The base of the pyramid is prevention. Prevention is the most effective. It's the most difficult. It's the hardest to understand, the most difficult trials to incorporate, but it is the base of the pyramid. And so let it be said that I don't think that we're going to solve cancer, cardiovascular disease by better treatment using CRISPR. My laboratory, and one of my companies before I happened to be wearing the jacket, but was one of the first to use CRISPR and transplant CRISPR. CRISPR, human beings with or CRISPR bone marrow into human beings long before anyone else, we were actually among the first. These human beings, thankfully, and astonishingly remain completely alive. We deleted a gene from their bone marrow. They engrafted with no problem. They're still alive today, and we are treating them for cancer. Astonishing fact, there are 12 of them in the world.(33:49):And again, astonishing fact, wonderful, beautiful news, beautiful science. But there are 12, if we want to make a big change in the universe, we need to get not to 12, but to 12 million, potentially 120 million. And that's not going to happen because we're going to CRISPR their bone marrow. It's going to happen because we change their environments, their diets, their lifestyles, their exposures, we understand their risks, their genetics, et cetera, et cetera, et cetera, et cetera. It's not going to happen because we give them CRISPR bone marrow transplants that enable them to change their risk of cancer. So I'm very clear about this or clear eyed about it, I would say, which is to say that great progress in medicine is being made. There's no doubt about it. I'm happy about it. I'm happy to be part of it. I'm happy to be in the forefront of it.(35:00):We have now delivered one of the first cellular therapies for cancer in India at a price point that really challenges the price point of the west. We are now producing this commercially and or about to produce this commercially, so for lymphomas and leukemias, I'm so excited about the progress in science. But all of that said, let me be very clear, the real progress in cancer and cardiovascular disease is going to come from prevention. And if that's where we're going, we need to really rethink at a very fundamental level as you have Eric, at a very fundamental level, how do we rethink prevention, cancer prevention, cardiovascular disease prevention, and as a correlate, regenerative disease, regeneration, cancer prevention, cardiovascular disease prevention. The fundamentals are how do we find things that are in our exposome, things that we're exposed to environments, gene environment interactions that increase the risk of cancer and cardiovascular disease, and how do we take them out? And how do we do this without running 15-year trials so that we can get the results now? And that's what I'm really interested in in terms of information.Eric Topol (36:55):Yeah. Well, I'm with you there. And just to go along with those 12 patients you mentioned, as you know recently it was reported there were 15 patients with serious autoimmune diseases, and they got a therapy to knock out all their B cells. And when their B cells came back, they didn't make autoantibodies anymore. And this was dermatomyositis and lupus and systemic sclerosis, and it was pretty magical. If it can be extended, like you said, okay, 15 people, just like your 12, if you can do that in millions, well, you can get rid of autoimmune diseases, which would be a nice contribution. I mean, there's so many exciting things going on right now that we've touched on, but as you get to it, you've already approached this inequity issue by bringing potentially very expensive treatments that are exciting to costs that would be applicable in India and many countries that are not in the rich income category. So this is a unique time it seems like Sid, in our advances, in the cutting edge progress that's being made, wouldn't you say?The Why on Cancer in the YoungSid Mukherjee  (38:14):Well, I would say that the two advances have to go hand in hand. There will be patients who are recalcitrant to the standard therapies, your patients with severe lupus dermatitis, et cetera. Those patients will require cutting edge therapy, and we will find ways to deliver it to them. There are other patients, hundreds of not 12, not 15, but hundreds of thousands if not millions, who will require an understanding of why there is an increase, for instance, in asthmatics disease in India. Why is that increasing? Why is there an increase in non-smoking related lung cancer in some parts of the world? Why? What's driving that? Why is there an increase in young patients with cancers in the United States? Of all things that stand out, there is a striking increase in colorectal cancer in young men and women. There's an increase in esophageal cancer in young men and women. Why?Eric Topol (39:58):Yeah, why, why?Sid Mukherjee  (40:00):Why? And so, the answer to that question lies in understanding the science, getting deeper information informatics, and then potentially understanding the why. So again, I draw the distinction between two broad classes of spaces where information science can make a big difference. On one hand, on the very left hand of the picture, an understanding of how to make new medicines for patients who happen to have these diseases. And on the way right hand of finding out why these patients are there in the first place, and asking the question, why is it that there are more patients, young men and women with colorectal cancer, are we eating something? Is it our diet? Is it our diet plus our environment? Is it the diet plus environment plus genetics? But why? There must be a why. When you have a trend like this, there's always a why. And if there's a why, there's always an answer. Why? And we have the best tools, and this is the positive piece of this. The positive piece of this is that we now have among the best tools that we've ever had to answer that why? And that's what makes me optimistic. Not a drug, not a medicine, not a fancy program, but the collective set of tools that we have that allow us to answer the question why? Because that is of course the question that every patient with esophageal and colorectal cancer is asking why.Eric Topol (42:01):I'm with you. What you're bringing up is fundamental. We have the tools, but we've noted this increase in colon cancer in the young for several years, and we're not any closer to understanding the why yet, right?Sid Mukherjee  (42:18):Yes. We're not any closer to understanding the why yet. Part of the answer is that we haven't delved into the why properly enough. These are studies that take time. They have longitude because these are studies that have to do with prevention. They take time, they take patients. So the quick answer to your question is, I don't think we've made the effort and we haven't made the effort, especially with the technological advances that we have today. So imagine for a second that we launched a project in which, again, like the Manhattan project, the Apollo project, we advanced a project which said the colorectal cancer in young project in the United States, we brought the best science minds together and ask the question, go into a room, lock yourself up, and don't come out of the room until you have the answer to figuring out how and then why we have young men and women with colorectal cancer increasing. I would imagine you could nominate, I could nominate 10 people to that committee and they would willingly serve. They'd be willing to be locked up in a room and ask the question why? Because they want to answer that question. That why is extraordinarily important.Eric Topol (44:14):I'm with you on that too, because we have the tools, like you said, we can assess the gut microbiome, their genome, their diets, their environmental exposures and figure this out. But as you say, there hasn't been a commitment to doing it.Sid Mukherjee  (44:30):And that commitment has to come centrally, right? That commitment has to come from the NIH, that has to come from the NCI, the National Cancer Institute, the National Institute of Health. It has to come as a mechanism that says, listen, let's solve this problem. So identifying the problem, there's an increase in colorectal cancer in young people. Important. Yes. Let's, let's figure out the answer why, and let's collect all the information for the next five years, seven years, whatever it might take to answer that question.Eric Topol (45:18):And as you said, the intelligent platforms will help analyze it.Sid Mukherjee  (45:23):Yes. I mean, we have the tools. So if you have the tools and if you collect the information, the tools will analyze that information.Eric Topol (45:36):Right. Well, this has been inspiring and daunting at the same time, this discussion. What I love about you, Sid, is you're a big thinker. You're one of the great thinkers in medicine of our era, and you also of course are such an extraordinary writer. So we're going to look forward to your next book and your rejuvenation of the cancer Emperor of All Maladies book but I want to thank you. I always enjoy our discussions. They always get to areas that highlight where we're missing the opportunities that we have that we're not actualizing. That's one of the many things I really love about you and your work, so keep up the good stuff and I look forward to the next chance we get to visit and discuss all this stuff.Sid Mukherjee  (46:31):And it's been a great pleasure knowing you for so many years, Eric. And then whenever we have dinner together, the dinner always begins with my asking you why. And so, the why question is the first question. The how question is a harder question. We can always answer the how question, but the why question is the first question. So the next time I have dinner with you, wherever it might be, San Diego, New York, Los Angeles, I'm going to ask you another why question. And you're going to answer the how question, because that's what you're good at. And it's been such a pleasure interacting with you for so many years.Eric Topol (47:12):Oh, thank you so much. What a great friend.Thanks for listening/reading to this Ground Truths conversation.If you found it stimulating, please share with your colleagues and friends.All content on Ground Truths—newsletter analyses and podcasts—is free.Voluntary paid subscriptions all go to support Scripps Research.Ground Truths now has a YouTube channel for all the podcasts. Here's a list of the people I've interviewed that includes a few that will soon be posted or are scheduled. Get full access to Ground Truths at erictopol.substack.com/subscribe

In conversation with Carl H. June, MD, Director of the Center for Cellular Immunotherapies, University of Pennsylvania Siddhartha Mukherjee won the 2011 Pulitzer Prize for nonfiction for The Emperor of All Maladies, a ''meticulously researched, panoramic history'' (The Boston Globe) of humankind's fight against cancer. It was awarded the PEN/E.O. Wilson Literary Science Writing Award, was named to numerous media outlets' ''Best of the Year'' lists, and was adapted by Ken Burns into a PBS documentary. Mukherjee is also the author of the No. 1 New York Times bestseller The Gene: An Intimate History. An assistant professor of medicine at Columbia University and a staff cancer physician at the New York-Presbyterian/Columbia University Irving Medical Center, he is a physician and researcher whose laboratory focuses on discovering new cancer drugs. His articles and commentary have been published in such places as Nature, New England Journal of Medicine, The New York Times, and The New Republic. In The Song of the Cell, Mukherjee takes readers through the centuries-spanning quest to understand cells, the tiny self-contained units that make up all life. Carl June is the Richard W. Vague Professor in Immunotherapy in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania. He is also the director of the Center for Cellular Immunotherapies at the Perelman School of Medicine and director of the Parker Institute for Cancer Immunotherapy at the University of Pennsylvania. Acclaimed for his research into the treatment of leukemia, he has published more than 350 medical papers and has received numerous awards and honors. Because you love Author Events, please make a donation to keep our podcasts free for everyone. THANK YOU! (recorded 10/5/2023)

Chapter 1 What's The Emperor of All Maladies"The Emperor of All Maladies: A Biography of Cancer" is a non-fiction book written by Siddhartha Mukherjee, an Indian-American physician and researcher. Published in 2010, the book provides a comprehensive history of cancer, focusing on its origins, treatment methods, and the ongoing battle against the disease. It explores the scientific, social, and personal aspects of cancer, and delves into the stories of patients, researchers, and physicians who have shaped the fight against cancer throughout history. "The Emperor of All Maladies" won the Pulitzer Prize for General Nonfiction in 2011 and has been widely acclaimed for its narrative style and depth of research.Chapter 2 Why is The Emperor of All Maladies Worth ReadThe Emperor of All Maladies by Siddhartha Mukherjee is worth reading for several reasons:1. Comprehensive and engaging storytelling: Mukherjee tells the history of cancer in a captivating and accessible manner. He weaves together personal stories of patients and their struggles with insightful scientific explanations, making the book suitable for both lay readers and those with a scientific background.2. In-depth exploration of a complex disease: Cancer is a multifaceted and elusive disease, and Mukherjee takes the time to explore its many aspects. He discusses its origins, the various treatments developed over the years, the social and political factors surrounding cancer research, and the implications for the future.3. Humanizes the disease: By sharing personal accounts of patients and their experiences, Mukherjee puts a face to the disease. This human perspective helps readers empathize with those affected by cancer and understand the devastating impact it has on their lives.4. Explores the triumphs and failures: The book covers both breakthroughs and setbacks in cancer research, highlighting the perseverance and determination of scientists throughout history. It gives readers a deeper appreciation for the complexities involved in fighting this disease.5. Raises important questions: The Emperor of All Maladies makes readers think about the ethical dilemmas faced by doctors and researchers in the field of cancer. It prompts discussions about the balance between scientific progress and patient welfare, the cost of treatment, and the role of societal attitudes toward cancer.Overall, The Emperor of All Maladies is a thought-provoking and informative book that offers a comprehensive overview of cancer, its history, and the ongoing efforts to understand and combat it.Chapter 3 The Emperor of All Maladies SummaryThe Emperor of All Maladies: A Biography of Cancer is a non-fiction book by Siddhartha Mukherjee published in 2010. The book provides a comprehensive and engaging narrative of the history, biology, and treatment of cancer.Mukherjee begins the book by tracing the origins of cancer, exploring its appearances in ancient civilizations and his own personal encounters with patients as an oncologist. He delves into the roots of cancer research, discussing key breakthroughs such as the discovery of DNA and the first successful treatments of childhood leukemia.The author then navigates through the evolution of cancer treatment, from early surgeries and radiation therapy, to the development of chemotherapy drugs like Methotrexate and Tamoxifen. He also explores the rise of cancer organizations such as the American Cancer Society and the National Cancer Institute, highlighting their impact on research and public awareness.Mukherjee also sheds light on the various challenges and controversies surrounding cancer research and treatment. He discusses the ethical dilemmas faced by...

Halle grew up in Minneapolis, MN and went to undergrad at St. Olaf College, a small liberal arts school about an hour south of the Twin Cities. She went to Medical College of Wisconsin in Milwaukee, WI and ultimately matched out in Philadelphia at TJUH for my urology residency. She graduated summa cum laude from St. Olaf and was inducted into Phi Beta Kappa. In medical school she was in AOA. She studied abroad twice in undergrad and recently went on a pediatric urology medical mission trip to Amman, Jordan.___0:00 - Intro0:42 - Statistics About Urology3:23 - Residency Trip to Amman, Jordan7:58 - Why Urology?15:10 - What Was Urology Residency Like?21:53 - If I Give You $100 Million, What Would You Do?23:28 - Best Things About Urology26:29 - Worst Things About Urology28:56 - Good and Bad Consults30:30 - Things You Wish You Knew Before Coming Into Urology31:19 - Common Myths About Urology31:57 - Memorable Patient Encounters34:36 - Advice for Students Looking Into Urology37:28 - Maximizing Competitiveness Going Into Urology40:32 - Were You Ever Burned Out?42:53 - Advice to People to Have a Successful/Long-Term Career46:11 - What Advice Would You Give Your 18-Year-Old Self?46:53 - Common Mistakes Made by Attendings48:38 - Positive Qualities & Characteristics Seen in Attendings49:40 - Favorite Book Recommendation51:23 - Closing Message53:59 - Outro___ResourcesThe Emperor of All Maladies by Siddhartha Mukherjee - https://amzn.eu/d/5llEmiM___View the Show Notes Page for This Episode for transcript and more information: zhighley.com/podcast___Connect With ZachMain YouTube: @ZachHighley Newsletter: https://zhighley.com/newsletter/Instagram: https://www.instagram.com/zachhighley/?hl=enWebsite: https://zhighley.comTwitter: https://twitter.com/zachhighleyLinkedln: https://www.linkedin.com/in/zach-highley-gergel-44763766/Business Inquiries: zachhighley@nebula.tv___Listen for FreeSpotify: https://open.spotify.com/show/23TvJdEBAJuW5WY1QHEc6A?si=cf65ae0abbaf46a4Apple Podcast: https://podcasts.apple.com/us/podcast/the-zach-highley-show/id1666374777___Welcome to the Zach Highley Show, where we discuss personal growth and medicine to figure out how to improve our lives. My name is Zach and I'm a medical student, and soon to be physician, in Philadelphia. Throughout these episodes I'll interview top performers from around the world in business, life, and medicine in hopes of extracting the resources and techniques they use to get to the top.The best way to help the show is share episodes on any platform. If you think a friend or family member will like a certain episode, send it to them!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

On this episode of BioTech IQ, Ammon interviews Paul Lammers the CEO of Triumvira about developing autologus cell therapies using their T-Cell Antigen Coupler Platform (TAC). During this insightful discussion Paul talks about how he started in the industry, running a biotech company in today's environment, and what sets Triumvira's T-Cell therapy apart from the rest! Don't miss it!Show support for show https://www.buymeacoffee.com/biotechiqCheck out the books recommended by Paul:CEO Excellence - https://amzn.to/3OGjI3GThe Emperor of All Maladies - https://amzn.to/3IDyZ1lSupport the showCheck me out on LinkedIn https://www.linkedin.com/in/ammonr/

The fingers on my hands are not enough to enumerate the number of television shows and films I have watched since childhood where cancer is made to be the death sentence and the divider of the families of either the main or supporting character. The protagonist feels a certain pain, is shown inside the doctor's office, and the physician somberly states, "You have cancer" or "You have six months to live." There is something so draconian about cancer that a book about the disease was titled "The Emperor of All Maladies." But is cancer truly a death sentence? What is the actual definition of cancer? What makes it different from a tumor? What do the infamous four stages mean? Is there a way that we can now track cancer's origins and hopefully evade the ultimatums that most shows have set? How toxic is chemotherapy, and what other treatments do we have available in the current age?We are joined today by Dr. Sanjay Juneja (aka TheOncDoc), a board-certified hematologist and oncologist, to tackle all things about the emperor of afflictions. He received his BS in Biology, Chemistry, and Philosophy from Louisiana State University in 2009, MD from LSU School of Medicine in Shreveport in 2013, Internal Medicine Residency at LSU Health Sciences Center in 2016, and Chief Hematology & Oncology Fellowship at Feist-Weiller Cancer Center in 2019. Dr. Suneja currently stands as an attending cancer specialist at the American Oncology Network in Louisiana, the Chief of Oncology Service Line at the Baton Rouge General Medical Center, and the Assistant Medical Director of Hospice at The Carpenter Health Network. Online, he provides education on cancer and the importance of screening as the host of the Target: Cancer Podcast and has been seen in The Washington Post, Thrive Global, WebMD, and the PBS Louisiana Public Broadcasting Special.Livestream Air Date: September 7, 2022Dr. Sanjay Juneja: IG @theoncdoc, YT @TheOncDoc, TikTok @theoncdocFriends of Franz: IG @friendsoffranzpod & FB @friendsoffranzpodChristian Franz (Host): IG @chrsfranz & YT Christian FranzThankful to the season's brand partners: Clove, BETR Remedies, Eko, Lumify, RescueMD, Medical School for Kids, Your Skincare Expert, Twrl Milk Tea

In today's episode of Category Visionaries, we speak with Hala Borno, Founder and CEO of Trial Library, an evidence-based platform for improving patient recruitment and diversity in oncology clinical trials, about why a more representative candidate pool is key to the future of better health for everyone. Trial Library partners with study sponsors to recruit candidates from a wide range of backgrounds to make sure that the principles of health equity are built into the process from the bottom up. We also speak about Hala's personal experience with her mother's care choices that led her to a career in medicine, how she balances maintaining a commitment to patients with the responsibilities of being a CEO, what it means to build a public benefit company with empathy as its ‘North star,'  and why diversity in clinical trials depends largely on healthcare providers' role as the gatekeepers. Topics Discussed: How her mother's personal challenges with overcoming health barriers led Hala to a career in medicine Hala's background as a researcher in health equity, and what that term means in the context of the modern economy What it's like to found a ‘public benefit company' with empathy as its guiding principle in a highly competitive economy How Trial Library generates income by acting as a recruitment intermediary for study sponsors and helping them meet diversity targets The challenges of keeping a commitment to patient health while also taking on the responsibilities of a startup CEO Why healthcare providers remain the gatekeepers to clinical trials, and what their role in achieving health equity in the future is likely to be   Favorite book:  The Emperor of All Maladies

Happy New Year! Enjoy these interviews with some of our favorite authors from 2022: Imani Perry, professor of African American Studies at Princeton University, shares the insights she gleaned about U.S. history and culture from her travels in the South from South to America: A Journey Below the Mason-Dixon to Understand the Soul of a Nation (Ecco, 2022), winner of the National Book Award for non-fiction. Siddhartha Mukherjee, physician and author of several books including The Emperor of All Maladies, The Gene, and his latest, The Song of the Cell: An Exploration of Medicine and the New Human (Scribner, 2022), talks about his new book that explores the new world of cellular medicine. Peniel Joseph, Barbara Jordan Chair in Ethics and Political Values, founding director of the Center for the Study of Race and Democracy, professor of history at the University of Texas at Austin and the author of The Third Reconstruction: America's Struggle for Racial Justice in the Twenty-First Century (Basic Books, 2022), talks about his new book that argues that since 2008, America has been experiencing a new Reconstruction, equal to the period following the Civil War and to the mid-20th century civil rights movement. Lydia Millet, climate novelist and author of several books, including Dinosaurs: A Novel (W. W. Norton & Company, 2022), joins to talk about her new book and how to find hope amid existential dread brought on by climate change. Andy Borowitz, author, comedian, and creator of The New Yorker's “Borowitz Report,” a satirical news column, and the author of Profiles in Ignorance: How America's Politicians Got Dumb and Dumber (Avid Reader Press / Simon & Schuster, 2022), talks about his new book that skewers politicians of the past 50 years plus shares humorous insights into some current politics.   These interviews were lightly edited for timing and rebroadcast; the original web versions are available here: Imani Perry's Journey Across the American South (Feb 4, 2022) Siddhartha Mukherjee on Medicine at the Cellular Level (Oct 28, 2022) Today's Reconstruction (Sep 6, 2022) A Climate Novelist on Hope and Dread (Oct 11, 2022) Andy Borowitz's 'Profiles in Ignorance' (Oct 26, 2022)  

Do you have reading resolutions for the new year? Whether you want to focus your efforts on reading outside your comfort zone or simply want to read more, check out these suggestions from librarians Katie, Meagan and Sarah. They also talk about book discovery resources and what they're looking forward to reading next. Titles mentioned in this episode include: Empire of Pain and Say Nothing by Patrick Radden Keefe; Rust Belt Femme by Raechel Anne Jolie; Olga Dies Dreaming by by Xochitl Gonzalez; The World Record Book of Racist Stories and You'll Never Believe What Happened to Lacey by Amber Ruffin; The Sunbearer Trials by Aiden Thomas; My First Popsicle, edited by Zosia Mamet; The Song of the Cell and The Emperor of All Maladies by Siddhartha Mukherjee; The Rabbit Hutch by Tess Gunty; Grace: President Obama and Ten Days in the Battle for America by Cody Keenan; A World of Curiosities by Louise Penny; and Now Is Not the Time to Panic, The Family Fang and Nothing to See Here by Kevin Wilson. Also mentioned: Archive of Our Own Check out books and movies at countycat.mcfls.org, wplc.overdrive.com and hoopladigital.com. For more about WAPL, visit westallislibrary.org. Music: Tim Moor via Pixabay

Oncologist and Professor of Medicine at Columbia University, Dr. Siddhartha Mukherjee, a Pulitzer Prize winner in non-fiction for his book, "The Emperor of All Maladies," explores medicine and the radical new ability to manipulate cells in his new book, "The Song of the Cell."Gastroenterologist Dr. Shilpa Ravella shares a riveting investigation of inflammation―the hidden force at the heart of modern disease―and how we can prevent, treat and even reverse it. Her book is, "A Silent Fire."

Today on How on Earth, Beth talks with Dr Siddhartha Mukherjee. His first book, The Emperor of All Maladies, won the Pulitzer Prize in 2011. His new book, The Song of the Cell, explores our radical new ability to manipulate cells. Mukherjee tells the story of how scientists discovered cells, began to understand them, and … Continue reading "Song of the Cell: Siddhartha Mukherjee's New Book"

Our guest this week is Morgan Housel. Morgan was one of our first guests on The Long View back in May 2019, and we're happy to welcome him back. Morgan is a partner at The Collaborative Fund, a venture capital firm. He is also a successful author—his first book, The Psychology of Money, having sold more than 2 million copies and been translated to 49 languages. In addition to his book, Morgan frequently publishes content to The Collaborative Fund's blog and is active on social media at @MorganHousel. He is a two-time winner of the Best in Business Award from the Society of American Business Editors and Writers, winner of The New York Times Sydney Award, and a two-time finalist for the Gerald Loeb Award for Distinguished Business and Financial Journalism. He also serves on the board of directors at Markel.BackgroundBioThe Psychology of Money, by Morgan HouselCollab BlogStorytelling and Advice“What's the Curse of Knowledge, and How Can You Break It?” by Loren Soelro, Ph.D., psychologytoday.com, April 28, 2021.Cancer: The Emperor of All Maladies, Ken Burns Presents a Film by Barak GoodmanRobert A. Weinberg“Best Story Wins,” by Morgan Housel, collabfund.com, Feb. 11, 2021.“Never Saw It Coming,” by Morgan Housel, collabfund.com, April 25, 2022.“Deep Roots,” by Morgan Housel, collabfund.com, March 31, 2022.Contradictions and EnoughThe Economist“Little Rules About Big Things,” by Morgan Housel, collabfund.com, Oct. 11, 2022.“Expectations (Five Short Stories),” by Morgan Housel, collabfund.com, Oct. 6, 2022.“Good Enough,” by Morgan Housel, collabfund.com, Sept. 7, 2022.“Surprise, Shock, and Uncertainty,” by Morgan Housel, collabfund.com, March 3, 2022.Randomness, Chance, and Happiness“Tails, You Win,” by Morgan Housel, collabfund.com, July 26, 2022.The Intelligent Investor: The Classic Text on Value Investing, by Benjamin Graham“Wealth vs. Getting Wealthier,” by Morgan Housel, collabfund.com, June 28, 2022.“Low Expectations,” by Morgan Housel, collabfund.com, March 9, 2022.Behavioral and HistoryThe Great Depression: A Diary, by Benjamin Roth“We'll Get Through This,” by Morgan Housel, collabfunds.com, March 9, 2020.Daniel KahnemanJason Zweig“The Big Lessons of the Last Year,” by Morgan Housel, collabfunds.com, April 2, 2021.

Siddhartha Mukherjee, physician and author of several books including The Emperor of All Maladies, The Gene, and his latest, The Song of the Cell: An Exploration of Medicine and the New Human (Scribner, 2022), talks about his new book that explores the new world of cellular medicine.

When thinking about the innovative technologies that are contributing to the evolution of digital health, the theme of collaborative efforts between clinicians and technologists continues to be central and of high-value. This episode focuses on the evolution of personalized medicine and the devices that are on the forefront of shifting the way healthcare is practiced as well as the clinical-expertise that helps along the way. This episode's guest is Dr. Ben Green who is an SVP of Services for AliveCor. Prior to AliveCor, Dr. Green spent 4+ years at Amazon where he was Principal of Healthcare Innovation for Global Benefits and the founding Chief Medical Officer for Amazon Care. Prior to Amazon, Dr. Green was the Regional Medical Director at Landmark Health, a patient-centered, comprehensive, house-call model designed for vulnerable patients. Prior to Landmark, Dr. Green spent 8 years at Carena, Inc. of Seattle where he was the Medical Director for Clinical Innovation. While there he helped to usher in the transition from in-person house calls to telemedicine model, and built a team of medical professionals focused on this novel field of medicine. He was directly involved in building the clinical software and operational infrastructure to deliver safe, high quality, and evidence-based primary care telemedicine. Dr. Green holds a BA from Harvard University in Biological Anthropology, an MD degree from the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and completed his Family Medicine residency at the University of Pennsylvania. Other topics in the episode range from how clinical executives are contributing to innovations in healthcare to best practices on career mapping to the historical presence of home health. For more details visit TechLink Health @ https://www.techlink.health or connect with Dr. Green @ LinkedIn Profile. This episode was hosted by Justine Reiss and Dr. Rodney Samaan. The episode has several references to the connection between tech and healthcare as well as technologies that are helping to evolve the industry. See below:

Do you feel like you have a good grasp of financial markets? Think again! In this episode, we take a plunge into the world of financial markets with experts Jules van Binsbergen and Jonathan Berk. Jules is a Professor of Finance at the Wharton School of the University of Pennsylvania and Jonathan is a Professor of Finance at Stanford Graduate School of Business. They also host a popular podcast called Else Equal, which explores the science and strategy of making better financial decisions, and have written several academic papers that challenge the status quo. In our conversation, we discuss their research on the relationship between manager skill and fund performance, the best ways to measure performance, and reasons why benefits are in favour of the managers. We also explore the dogma surrounding mutual funds, the differences between active and passive management, and how to measure efficient capital markets. Listeners will also hear perspectives that challenge their understanding of capital markets and viewpoints that completely disagree with previous guests. Although we have covered this topic before in previous episodes, this conversation will fundamentally change the way you view financial markets and how to think about them.   Key Points From This Episode:   What information fund performance contains about manager skill. (0:04:04) Reasons why manager skill and performance are unrelated. (0:04:59) We learn how manager skills should be measured. (0:06:57) How to choose the appropriate benchmark to measure value added. (0:09:26) Find out if you can use factor-mimicking portfolios to measure risk-adjusted returns. (0:12:05) Whether funds that directly target risk factors can be used as an investable benchmark. (0:16:35) What the skill of active managers are when skill is measured as value-added. (0:20:52) The proportion of value-added between security selection and market timing. (0:23:20) Discussion about how persistence manifests when it is measured by value-added. (0:25:43) Find out if investors should analyze mutual fund companies as opposed to managers. (0:32:36) Discover why research has focused on individual security pricing and not on evaluating manager skill. (0:34:25) We unpack the reasons why it's a zero net alpha as opposed to a negative net alpha in equilibrium. (0:38:19) We delve into why the research took so long to apply rational expectations to fund investors as with the stock market. (0:42:46) An explanation of how equilibrium zero net alpha fits into Bill Sharpe's arithmetic of active management. (0:48:16) Who benefits from the high amount of skill available within the sector. (0:51:11) Whether the increase in millionaires around the world drives inequality. (0:56:12) Hear if it is possible to identify skilled fund managers before the benefits of their skills are absorbed by fund size. (01:01:41) The implications on efficient market hypothesis for the stock market. (01:05:36) Advice for investors, considering that the benefits of skill are in favour of managers. (01:08:37) Details about their research on how multi-factor asset pricing models are not representative of risk. (01:12:45) We end the show by learning how our guests define success in their lives. (01:19:08)    Links From Today's Episode:   Jules van Binsbergen — https://sites.google.com/view/jules-van-binsbergen/ Jules van Binsbergen on LinkedIn — https://www.linkedin.com/in/jules-van-binsbergen-a7b21a2/ Jules van Binsbergen on Google Scholar — https://scholar.google.com/citations/ Wharton School of the University of Pennsylvania — https://www.wharton.upenn.edu/ Jonathan Berk — https://www.gsb.stanford.edu/faculty-research/faculty/jonathan-b-berk Jonathan Berk on LinkedIn — https://www.linkedin.com/in/jonathan-berk-07874a3b/ Jonathan Berk on Google Scholar — https://scholar.google.com/citations/ Stanford Graduate School of Business — https://www.gsb.stanford.edu/ Else Equal: Making Better Decisions — https://www.gsb.stanford.edu/business-podcasts/all-else-equal-making-better-decisions Passive in Name Only — https://heinonline.org/HOL/LandingPage/ The Emperor of All Maladies — https://www.amazon.com/Emperor-All-Maladies-Biography-Cancer/dp/1439170916 Unsettled — https://www.amazon.com/Unsettled-Climate-Science-Doesnt-Matters/dp/1950665798 ‘Episode 200 with Prof. Eugene Fama' — https://podcasts.google.com/feed/aHR0cHM6Ly9yYXRpb25hbHJlbWluZGVyLmxpYnN5bi5jb20vcnNz/episode/MzA2MjM2OTctOTc5Yy00MDU4LWE3YzMtYTdmMGU4NGQ0Y2Jj?sa=X&ved=0CAIQuIEEahgKEwjI27ng_rH6AhUAAAAAHQAAAAAQsQQ Rational Reminder on iTunes — https://itunes.apple.com/ca/podcast/the-rational-reminder-podcast/id1426530582. Rational Reminder Website — https://rationalreminder.ca/ Rational Reminder on Instagram — https://www.instagram.com/rationalreminder/?hl=en Rational Reminder on YouTube — https://www.youtube.com/channel/ Benjamin Felix — https://www.pwlcapital.com/author/benjamin-felix/ Benjamin on Twitter — https://twitter.com/benjaminwfelix Benjamin on LinkedIn — https://www.linkedin.com/in/benjaminwfelix/ Cameron Passmore — https://www.pwlcapital.com/profile/cameron-passmore/ Cameron on Twitter — https://twitter.com/CameronPassmore Cameron on LinkedIn — https://www.linkedin.com/in/cameronpassmore/  

In part one of this ASCO Education Podcast episode, director of the U.S. Food and Drug Administration's Oncology Center of Excellence Dr. Richard Pazdur talks with hosts Dr. David Johnson and Dr. Patrick Loehrer about his upbringing in Indiana, his family, and his circuitous route to oncology. If you liked this episode, please subscribe. Learn more at https://education.asco.org, or email us at education@asco.org.   TRANSCRIPT Dr. Pat Loehrer: Hi, I'm Pat Loehrer. I'm the director of the Center of Global Oncology and Health Equity at Indiana University. Dr. David Johnson: I'm Dave Johnson at UT Southwestern in Dallas, Texas. Pat, great to be back with another episode of Oncology, Etc, an ASCO educational podcast. We have a very special guest today, Dr. Richard Pazdur, from the FDA Oncology Center of Excellence. I'm really looking forward to this conversation. Dr. Pat Loehrer: This will be terrific. Dr. David Johnson: Yeah. You were telling me before we got started about a little event that occurred this week, maybe you want to elaborate on that for us. Dr. Pat Loehrer: Yeah, we always start out this by talking about books, and one of the books I'm drawn to today is a book called, The Emperor of All Maladies, which was written by Dr. Mukherjee several years ago. I want to read a little bit from this because it has pertinence. This is about a guy named John Cleveland. Dr. Mukherjee writes, he goes, ‘In 1973 Cleveland was a 22-year-old veterinary student in Indiana. In August that year, two months after his marriage, he discovered a rapidly enlarging lump in his right testis. He was whisked off to the operating room for surgery and returned with a scar and he was diagnosed with metastatic testis cancer. This was right around the time that Larry Einhorn came to Indiana University where he was treated with a three-drug cocktail of actinomycin-D, bleomycin, and oncovin ABO. And then he had a brief remission progressing and was treated with mithramycin mithrymicin. And then in October of 1974, he once again developed progressive disease, and Larry approached him about a new cocktail with the drug cisplatin, that had never been used before in combination, and Larry's thought was to put it together with another couple of drugs.” So, I'll just finish reading this. “In October 7, 1974, Cleveland took the gamble, he enrolled as patient zero for BVP, an acronym for the new regimen containing Bleomycin, Vinblastine and cisplatin. 10 days later, he returned for routine scans and the tumors in his lungs had vanished. He was ecstatic and mystified. He called his wife from the hospital phone. I can't remember what he said, but I told her the results. So, John was the first one cured of testis cancer. Back then it was a 5% cure rate. Today, it's 95%. He is really the hero of heroes. Last week, at this time, John had asked me to come to his hospital room because he was diagnosed with metastatic cancer of a different type. He knew that this was basically the final hours of it. And so he wanted to say goodbye to me, and it was the most touching reunion I had. Two days ago, John passed away. So, my thoughts are with him, especially his family. But also, when we think about heroes, John was one of them, and if it wasn't for him, and his first treatment, Larry might not have gone on and treated other patients with this regimen. This drug cisplatin was experimental back then it caused a lot of nausea and vomiting and didn't work in many tumors, but this was a drug that was really highlighted and approved for the treatment of bladder cancer so Hubert Humphrey could get treated, and then in testis cancer, and it's really one the really success stories of all success stories in terms of oncology, and it started out with this experimental drug from the NCI that was approved by the FDA.” So, this leads us to our guest today, Rick Pazdur who I've known for many years. He grew up in Calumet City, Illinois, which is famous as the home of the Blues Brothers and Rick Pazdur. He got his bachelor's degree from Northwestern, his medical degree from Loyola Stritch Medicine, and then did his hematology-oncology fellowship, initially his oncology fellowship at Rush Presbyterian St. Luke's, where I first met Rick, and then later finished his Heme-Onc fellowship at the University of Chicago. From there, he went to Wayne State, served on the faculty there for about five or six years, and then joined the faculty at MD Anderson. He was there from 1988 to 1999. Then, we'd like to hear about this, but for some reason, it got in his head that he wanted to go to the FDA and so he moved to the FDA where he was Director of the Division of Oncology Drug Products, from 1999 to 2005, when they created the Office of Hematology Oncology Products, and he became the Director of this. More recently, he's been made the director of the FDA's Oncology Center of Excellence. He still serves as the acting director for this OHOP. Rick is an extraordinary individual. He's been awarded a number of awards. From ASCO, he got the Service Recognition Award and the Public Service Award in 2013. And the AACR also awarded him the Public Service Award in 2015. He's received numerous awards and he is probably one of the most respected oncologists that I know in this society. It's such a great pleasure to have you here today, Rick. Dr. Richard Pazdur: My pleasure, Pat. My pleasure entirely. I look forward to the conversation. Dr. David Johnson: Pat, you left out one award. He got so many awards that you can't list them all, but I was impressed that he got this award for the Massachusetts General Hospital Cancer Center's – The 100 list. Dr. Pat Loehrer: Yeah, we made the cut-off. Dr. David Johnson: I have no idea what that is. Dr. Pat Loehrer: We were on the 1001 list. We made that one. The only thing I want to throw into is that when I first met Rick, when I was a resident or an intern, I think, he was on the service with Phil Bonomi, who is very important for me for my thymoma research, but there was an oncology nurse on the service, Mary Lind, who was a terrific oncology nurse as they all are. But it turned out there was more chemistry that went on. So, Rick ended up marrying Mary, and I'm sure he'll tell some stories. We'll come back to that in a little bit, too. Dr. David Johnson: Yeah, this is really exciting. So, let's get started. Rick, maybe you could tell us a little bit about your background and what got you into medicine in the early part of your career. Dr. Richard Pazdur: I had an interesting story. Pat had mentioned Calumet City home as a Blues Brothers. That was the orphanage in the movie. It was located in Calumet City. But what you don't know about Calumet City is that the real kind of nickname for Calumet City in the 50s 60s 40s was 'Sin City'. It has the honor of having the greatest number of liquor licenses in the United States. And in Calumet City, which was on the border of Hammond, Indiana, and Calumet City, they're kind of Sister Cities. They're one in Illinois, Calumet City. And Hammond is in Indiana, obviously, there was this strip, and it was called ‘The Strip' and it had all of these bars and floor shows with Sally Rand and gambling. If you walk down there, which I never did as a kid, but drove down there with my father some time just traversing the city, those lights were so bright, it was just like Las Vegas, basically. So, you had that Strip and that went on for maybe three, four, or five blocks. And then you have the rest of the city that I grew up in, which was primarily a Polish Catholic city, which I am kind of a representative of being 100% polish. There were scattered bars throughout the city. In fact, my fondest memory is sleeping in bed at 3 o'clock in the morning or 2 o'clock in the morning, awakening to people running out of a bar, which was 50 feet or 100 feet from my bedroom window. They were screaming and yelling and cursing and everything and throwing beer bottles at each other. And in those days, obviously, as you remember, in the 60s, there was no air conditioning. So, the bar was called The Tropical Inn. Let me tell you this, there was nothing tropical about it and there was nothing 'in' about it. Dr. David Johnson: That background might have driven…. Dr. Richard Pazdur: That was not what I would call a highbrow area, but I enjoyed it. It was a fabulous childhood that I had. Most people don't know this. So, I will share this with you because it really had an indelible mark on my life and something that really transformed my childhood and my high school years and my college years, and my medical school years. When I was about in seventh or eighth grade, my father who was basically a blue-collar factory worker, developed glaucoma, and he went blind at a very early age. And that threw the family into not only emotional turmoil but also economic turmoil. I survived basically by getting Social Security dependent income and had to work at a very early age. I started as a dishwasher. My mother lied about my age so I could start working at a crummy restaurant in Calumet City as a dishwasher and I worked throughout school, but that experience really made me grow up really fast if I could say so. You didn't have a childhood, you had to be responsible because there was really no security blanket to fall back on. Although my parents didn't have a lot of money, they really had very good emotional support for me and both my father and my mother came from very large, Polish families. My mother had nine children in her family. She was right in the middle. And so, I had many cousins and many aunts and uncles and my father had seven children in his family and he was the oldest boy. So, there was a lot of support there, but obviously not a lot of financial support. So, it really made me grow up relatively quickly and really come to some of life's lessons, relatively fast like discrimination against disabled people, which I will always remember. When I was a boy, I remember going with my father walking and obviously he had a white cane, but walking down the street, people would actually cross the street to avoid us. They just didn't want to confront that anxiety. I don't know if it was discrimination or if they just felt uncomfortable dealing with it. When you go to a restaurant, people raise their voices, like the man was mentally impaired and that wasn't the case. Dr. Pat Loehrer: I'm sorry to interrupt you just for a second because I read this somewhere and I think it's important to throw in. So, you graduated from high school in three years? Dr. Richard Pazdur: Yes, that's what I was gonna say. I graduated and I worked during that time also. These jobs were not like jobs that kids have now as consultants or internships, these were like real jobs as a janitor, a gardener, or a packer in a grocery store. You had to do it and you had to compartmentalize your life to get things done, basically. But you were driven to do things and I'm thankful for that experience really. I even use it now when I'm facing turmoil in my life. I look back at that time and say to myself, Rick, if you did it then as a 12-year-old kid, a 14-year-old kid, you could do anything. So, it really fostered a sense of responsibility, self-awareness, and the need to do things for yourself and get going on yourself. because nobody's going to help you in a sense. I'm very grateful for that. Dr. David Johnson: Rick, at what point did you decide to become a physician? How did that experience really drive you into that field? Dr. Richard Pazdur: Well, I spent a great deal of time in the lobby of the University of Chicago hospital with my father. I was the primary caregiver and went with him to his doctor's appointments. I can't tell you the number of hours I spent in the lobby of that hospital. I was very interested in science. I was very interested in really helping people because of that background. I really had a great deal of clarity, though. I remember, when I was maybe a freshman or sophomore in high school, I wrote for the Northwestern Medical School catalog, because I thought I would be going to Northwestern undergraduate, I already decided in my own mind that that's where I wanted to go. I just got their medical school catalog and I was thumbing through it, and I remember this vividly sitting on my bedroom floor next to the window that was 50 feet away from the bar, basically, and was looking through the medical school catalog and seeing all these names of this doctor, head of neurology, assistant professor, associate professor. I said, “Hell, if I'm going to be a doctor, I want to be one of these people. I want to be the best doctor. I want to be teaching the physician here and doing research.” So, unlike most kids today that have to find themselves, like, ‘I'm going to take 8 years to complete college or something like that and take a year off to find myself.' I had to be very, very focused on what I wanted to do. So, I really worked very hard during it through time. I don't regret it, as I say. I went to Northwestern undergraduate and had a fantastic experience there. I graduated in three years as I mentioned. I had a special interest there that most people don't know about. The people at the FDA know about it. I did these pre-med courses but I had a really special interest in the field of sociology, and actually was toying with the idea if I didn't get into medical school to pursue a Ph.D. in Sociology and become an academic sociologist. If you remember and both of you are of this age. Dr. Pat Loehrer: David is, not me. Dr. Richard Pazdur: Okay. David might know of the Vietnam War. This was right around the time of Kent State and closing down the schools, I'm sure you remember that, for the colleges, etc. Nobody went into business or anything like that. It was a sociology, psychology, and anthropology type of things people were interested in. My love was this field, and I did a lot of research on it. I remember one of the professors that probably had the most influence on me, a woman called Zena Smith Blau, who was a sociologist, and I did multiple research projects and independent studies. The first thing when I took her first course, she assigned us a paper and she said, write about yourself, ‘What makes you unique? I went to see her and I said, ‘I really don't know exactly what you mean by this.' She said, ‘Well, how different are you?' And I said, ‘Well, my parents are children of Polish immigrants, and I really know the Polish community in Chicago fairly well.' She said, ‘That's it Rick, that's what your specialty will be.' I did multiple research projects on this area with her. Some of them were like the assimilation of Polish immigrants with regard to urban-rural origin. Another one was working-class youth in Chicago, and mobility based on education and high school part-time employment. So, that was a fantastic experience that is totally outside of what I did in my future. Dr. David Johnson: We asked our listeners to submit questions because we knew you were coming on. We did get a question that perhaps is appropriate to ask at this time. It comes from a younger trainee, who wants to know what advice you would give to a trainee aspiring to have a clinical investigative career in oncology? What sort of preparation should they have? Obviously, you've got to learn all of the techniques of clinical trial designs, statistics, etc. But what other advice would you give a trainee hoping to pursue a career in clinical investigation? Dr. Richard Pazdur: I think one's career always has to go back to the basics and have a patient focus. So, what is your interest in the patient, so to speak? And that is what advice I would give them. Are you interested in a supportive care issue? Are you interested in a specific disease? I think you have to follow a passion and that is what is most important to me. What is your passion in life? Because as physicians, we spend a great deal of time preparing for our careers and then subsequently afterward, in our designated careers, and you really can't approach this as a job. It has to be a passion. So, if you do have this, what are the questions that you really want to answer? What is the field that you want to go into and make an indelible mark in? So, that's what I come from, and that's something that I tell our staff is: what do you really want to do? What makes you happy? What would make you a success in your mind? Not defining yourself by somebody else. Dr. Pat Loehrer: Finish the story a little bit. Was it a patient then that turned you on to oncology? What brought you into oncology? Dr. Richard Pazdur: I had a very circuitous circular route to oncology. Oh my God! I don't know if you have enough time to hear this story, but let me start though. I originally went to medical school because of my background in sociology. I wanted to become a psychiatrist because here again, I thought psychiatry, sociology, and psychology, these are kinds of things I was interested in until I took my first rotation in psychiatry. It was nothing like I thought it was going to be. I saw my first patient that got ECT (Electroconvulsive Therapy) and I said, 'I ain't doing this.' So, I was then interested in cardiology. Loyola at that time where I was going to medical school and where I did my internship and residency, had a huge cardiology program that was like CAST city, USA. Everybody was just coming into the hospital getting CAST and going out of the hospital. Dr. Pat Loehrer: [Unintelligible 18:13] was there, right? Dr. Richard Puzdar: Yes. Mary Kate [Unintelligible 18:18]'s father was the head of medicine there. And it had a huge cardiology program and an excellent cardiology program. I really did like Clinical Oncology, and I was all signed up for a cardiology fellowship, the Ts were crossed, the dots were placed, the contract signed, and everything. And somebody said, ‘Rick, why don't you take a rotation while you're a resident in the cath lab? We have an opening and this would be a great time and opportunity for you to jumpstart your fellowship. So, you can come and work for us in the middle of your third year of residency for about two or three months.' So, I did that and I hated it. I just dreaded it. I couldn't stand it. It was the most boring thing. I would think of every opportunity to escape the Cath lab. It was the same thing over and over and over again, inject the dye, turn on the [Unintelligible19:16] machine, and follow the coronary arteries. So, I happened to go to a community hospital, St. Francis in Evanston, Illinois, and I met an oncologist there that had just finished her fellowship. I really was very impressed by her clinical skills. She had finished her fellowship at the University of Chicago and worked with her there and was just amazed by really the quality of care that the oncologist gave patients with cancer. Previous to that, I had an interest also in oncology. At Loyola at that time, we had an oncologist his name was Ketty Badrinath, and he was an excellent clinical teacher. Now that I decided that I'm not going into cardiology, the first problem I have is to find a job and to find a fellowship in oncology. So, I started investigating oncology programs at St. Francis Hospital there. I went down to the gift shop and I said, I want $10 worth of quarters. I went to a payphone, closed the door of the payphone, dialed information, and got every oncology program that I could think of from Mayo Clinic to all of the programs in Chicago. One of my last phone calls was to Rush Presbyterian. I found that program director, Jules Harris, I don't know if you remember him, and he said, “We have an opening.” So, I accepted the position. At the end of June, whatever it was, June 27, 1979. I started my oncology fellowship program. Now Oncology at that time in Chicago, to give you a picture of it, the largest program in oncology was at Rush. It had a total of 12 people. And the therapy started at Rush around solid tumors really in the endocrine therapies of prostate cancer and breast cancer. So, it was a different program than most programs throughout the United States that were offshoots of Hematology programs and the treatment of acute leukemia and lymphomas. So, it had a really kind of different orientation. So, I started my fellowship. And on the first day, I met Phil Bonomi, who had a tremendous influence and still has an influence over me. I know no doctor that I respect most more than Phil. I think the greatest compliment that one could give a doctor is to refer your own family to him. And I've done it on numerous occasions with various cousins and aunts and uncles, etc. But as you mentioned, Pat, I also had the opportunity to meet my wife. And I met her and at first, we were very good friends and there was no romantic relationship. And then, as time proceeded, we knew that there was something special there. My wife was just a wonderful person. Like myself, my wife was pretty much a self-made person. She was one of eight children, the oldest daughter. As the oldest daughter, she had to assume a lot of childcare responsibilities, cooking, etc, for all of her brothers and sisters and took care of the younger children. But she was an excellent student. She graduated first in her class. She was a national merit finalist. I often asked my wife, ‘Mary, you're a nurse, are you interested in going into medicine? I'll be happy to work with you to get you into medical school.' And she said, ‘No, you want to go into medicine, I want to go into nursing.' That was her orientation toward other people. It wasn't about the buck. It wasn't about the title. It was about the work of helping other people. I really have to honor her mother and father who gave her that orientation. Of interest, all of her sisters are nurses. Her mother was actually a school nurse, and an original graduate of Rush. She went to Rush Nursing School in the 50s but had to leave because at that time in the 1950s, if you got married, you can't be in nursing school, they kicked you out. So, it shows you how times have changed.   Dr. Pat Loehrer: Well, this concludes part one of our interview with Dr. Richard Pazdur who is the director of the US Food and Drug Administration's Oncology Center of Excellence. Stay tuned for part two of this conversation where we'll hear how cancer has touched his life personally and will explore the initiatives and programs, he started to improve patient care globally.   Thank you to all of our listeners for tuning into Oncology, Etc. This is an ASCO education podcast where we'll talk about just about everything and anything. If you have an idea for a topic or guests you'd like to see on the show, please email us at education@asco.org. Have a good week.   Unknown Speaker: Thank you for listening to the ASCO Education podcast. To stay up to date with the latest episodes. Please click subscribe. Let us know what you think by leaving a review. For more information, visit the comprehensive education center at education.asco.org.   The purpose of this podcast is to educate and inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.    

In this episode of Out of the Clouds, host Anne Muhlethaler reconnects with Archana Jain, an accomplished PR and communications professional, and the founder of PR Pundit, one of India's top integrated communications firms. Archana has been at the forefront of her industry since her early days in the field and is widely recognised as a leading personality in PR, communication and media. She has been acknowledged as India's top 100 PR communications professionals, as well as among India's 50 Most Influential Women in Indian Media, Marketing & Advertising (2019, 2020 & 2021) and featured in the “Top 100 Influential Game Changers List.”Anne and Archana collaborated a few years ago, and got to know each other, back when Anne was heading global communications for French shoe designer Christian Louboutin. Over the course of this conversation, Archana tells the story of her beginnings in PR, how she went from consulting into working towards consumer-focused communication, to building her company and creating meaningful programs for the right audiences. She talks to Anne about why public relations still matters today, how it's imperative for brands to be telling authentic stories and why PR is a long game - not a quick win, and current challenges given that it's not an age-old profession. They also discuss changes in the media landscape and the rise of purpose-driven communications and community advocacy, in the age of social media. Archana also offers her thoughts on what it's been like to be a woman at the head of her own business, how the landscape changed in the past twenty years, but also how she chose to  integrate flexibility and WFH capabilities for her team since 2004 - and how satisfying it's been for her to be able to help women balance their personal and professional commitments. You'll probably notice a loud peacock (or two) in the background, as some were roaming behind Archana's home office during the interview. A good way to set the scene for this warm and in-depth interview with this influential entrepreneur. Happy listening!  ***Selected links from the episode:You can find Archana on IG @AJPundit and on Twitter @AJPunditOn LinkedIn Archana Jain Find out more about PR Pundit on their website http://www.prpundit.com/ - or on IG https://www.instagram.com/PRPundit/The origin and meaning of the word Pundit - https://en.wikipedia.org/wiki/PunditTripundra - https://en.wikipedia.org/wiki/TripundraVogue India - https://www.vogue.in/Adidas Run for the Oceans campaign - https://thecsrjournal.in/adidas-run-for-the-oceans-unites-over-87k-runners-across-india/Archana's interview on CommSpeak with Amith Prashu - https://youtu.be/1Zn2uWJARo0The German tampon PR campaign by Female Company via The GuardianThe exceptional Kate Winslet for L'Oréal campaign - https://www.youtube.com/watch?v=mjcd6Xu4MYUParvati Valley - https://en.wikipedia.org/wiki/Parvati_ValleyKashmir Shaivism - https://en.wikipedia.org/wiki/Kashmir_ShaivismThe Hungry Tide, book by Amitav Ghosh https://www.goodreads.com/book/show/4950.The_Hungry_TideA suitable boy, the book by Vikram Seth https://www.goodreads.com/book/show/50365.A_Suitable_BoyThe Emperor of All Maladies, a biography of cancer, the book by Siddhartha Mukherjee https://www.goodreads.com/book/show/7170627-the-emperor-of-all-maladies***f you enjoyed this episode, click subscribe for more, and consider writing a review of the show on Apple Podcasts, it helps people find us and also helps to secure future guests. Thank you  so much for listening! For all notes and transcripts, please visit Out Of The Clouds on Simplecast - https://out-of-the-clouds.simplecast.com/  Sign up for Anne's email newsletter for more from Out of the Clouds at https://annevmuhlethaler.com. Follow Anne: Twitter: @annvi  IG: @_outoftheclouds 

Tom is an Executive Producer for WETA, the flagship PBS station in the nation's capital, developing programming for 330 stations in 150 markets throughout U.S. Recent projects include Ken Burns Presents The Gene: An Intimate History, Rethinking High School with Soledad O'Brien at Howard University / XQ Super Schools Project, the DuPont Columbia Award winning / Emmy nominated documentary series Cancer: The Emperor of All Maladies. In production/development: Hiding In Plain Sight: Our Mental Health Crisis; The Caregiving Project; Life, Unexpected; Critical Condition: Rural Health In America; and LGBTQ in America. Recent projects include Emmy nominated documentary series Ken Burns Presents The Gene: An Intimate History (2020); Rethinking High School with Soledad O'Brien - Town Hall at Howard University / XQ Super Schools Project (2016); and DuPont Columbia Award & Emmy nominated documentary series Ken Burns Presents Cancer: The Emperor of All Maladies (2015). Documentaries in production and development (2022 through 2025): Hiding In Plain Sight: Youth Mental Illness; Remote Chance: Rural Health Care In America; Caregiving; Life, Unexpected; Mighty Real: Out & Proud In America, GERMS, among other projects. Thirty years' experience in the media, communications, television and entertainment industry, Tom was formerly SVP business development at Entertainment Industry Foundation - creating programs and funding key national initiatives in health care, volunteerism, childhood hunger and education, including Stand Up To Cancer (US & Canada), iParticipate, Rise and Honor, Hunger Is and ThinkItUp. Tom has held senior positions at Rubenstein Associates; U.S. Department of Health and Human Services, Massachusetts State Office for Children & Department of Public Health, and Manhattan Repertory Company. Former clients include HBO, AMC; TIME, Inc.; Wenner Media; Columbia University Humanities Festival; Major League Baseball; (RED); Al Roker Entertainment, Inc.; The Tony Awards; ABC's Good Morning America; Chances for Children; and The Apollo Theatre. Tom is a published playwright, and co-author of “Home Care for Respirator Dependent Children” New England Journal of Medicine. Check out That Pop Culture Show via their YouTube Channel Youtube.com/Thatpopcultureshow with new episodes debuting on Fridays. That Pop Culture Show is around table talk show with celebrity guests, collectors and experts talking about and celebrating pop culture. Join hosts Kody Frederick and Jason DeBord with guests from the world of pop culture, including film, television, rock 'n' roll, sports, contemporary and street art, comic books, geek culture and more. Each episode features a profile of the guest, a discussion of current pop culture topics, and a close look at an artifact of collectable the guest has brought in to share. This includes in-depth looks at prized pieces of memorabilia, works related to their careers, or any other interesting artifact that has meaning to them in their lives. Please like and subscribe to support our efforts to celebrate pop culture.Follow us on www.ThatPopCultureShow.com

“The older I get, the more I realize how skateboarding shaped who I am.” Ian Rogers definitely knows how to get out of his comfort zone to land a trick. The switch from innovative music streaming services (Apple Music) to taking luxury brands online (LVMH Group) was a bold one. A strong believer in growing from discomfort, Ian definitely sees opportunity rather than risk. One thing is sure, the man knows how to roll with the times without ever losing sight of his passions, from working with The Beastie Boys to collecting NFTs. Even though he'll tell you that “being early is the same as being wrong”, Ian is always on the edge of things with a unique sense of timing. The key to it all? Doing things with conviction and focusing on the future. Faster, better, stronger would be a good soundtrack! In this episode, Ian shares a few lessons from mentors and his time at Apple Music and LVMH: Get really good at saying no to good ideas, so you can get the important things done. (Apple Music) Focus on three things that will move the needle. (Tony Belloni, LVMH) Back creativity with operational efficiency. (Bernard Arnault, LVMH) Tailor your communication strategy to whoever you are trying to reach. Obsessed with what's next, Ian is way ahead of us and practically longs for the day his passport will be an NFT. In this conversation he tries to catch us up on what we're missing out on, and his latest big leap: Ledger. If “living in the future is cheating”, as the man himself claims, then he is damn good at it! TIMELINE: 00:15:49 : A career lived on the edge of things at the right moment 00:32:28 : Cryptocurrency and digital innovation into a household name like LVMH 01:15:43 : NFTs, building ecosystems and their own economy 01:53:50 : Using data for big groups 02:02:45 : Beats, Apple, LVMH and Ledger 02:22:50 : Being online, quitting social media (except for Twitter) Episodes of GDIY we talked about with Ian: #228 - Nicolas Julia - Sorare - Le tsunami français du WEB 3.0 : créer, posséder et échanger du virtuel #229 - Frédéric Montagnon - Arianee - Le WEB3 pour se réapproprier Internet #243 - Eric Larchevêque - Ledger - Le club secret des crypto millionnaires : bitcoin, transmission, savoir et slowlife Ian's reading recommendations: The Company, A Short History of a Revolutionary Idea, Adrian Wooldridge and John Micklethwait The KLF: Chaos, Magic and the Band who Burned a Million Pounds, John Higgs Stranger than we can imagine, John Higgs Please Kill Me: The Uncensored Oral History of Punk, Legs McNeil This is How They Tell me the World Ends, Nicole Perlroth The Emperor of All Maladies, Siddharta Mukherjee Show notes: Episode #86 - La Martingale with John Karp on NFTs Episode #100 - La Martingale with Jean-Michel Pailhon on NFTs “The Solitary Arts” Geoff McFetridge The Beastie Boys Book, Michael Diamond & Adam Horowitz, 2018 CU-SeeMe Twitter account : Web3 is going just great A Mashiro The World According to Punk 6529 - Raoul Pal Bright Moments exhibition Bandcamp PROOF - Kevin Rose Podcast with Matt Kane (Gazers) PROOF - Kevin Rose Podcast with Derek Edward Shloss (art collector) VeeCon Web3 conference The Defiant Ones, 2017 Supreme skateboard case by LVMH David Golberg at Yahoo & Sheryl Sandberg's late husband The Knowledge Project podcast- episode 68 Daniel Kahneman Bernard Arnault, LVMH Tim Cook, Apple CEO Jake Phelps, Thrasher Magazine Editor Nicolas Julia, founder of Sorare Éric Larchevêque, cofounder of Ledger Darius Rucker, Hootie and the Blowfish Ian Rogers NFT gallery Like the music credits? They are composed by Morgan Prudhomme! Contact him at: https://studio-module.com. Do you want to sponsor Génération Do It Yourself or partner with us? Contact my label Orso Media via this form. Special thanks to Olivier Le Garlantezec for connecting me with Ian. If you too want to protect your crypto assets, there is nothing better than a Ledger. Order yours now by clicking here. You can follow Ian on Twitter : @iancr

"Plus je vieillis, plus je réalise à quel point le skateboard a façonné qui je suis." Ian Rogers sait comment sortir de sa zone de confort, sa vie étant une quête infinie d'apprentissages et d'aventures. Passer d'un service de streaming (Apple Music) à la digitalisation de marques de luxe pour LVMH n'était pas un pivot évident. Ian fait partie de ceux qui voient l'opportunité plutôt que le risque et est convaincu que l'inconfort élève les gens. Une chose est sûre, il sait évoluer avec son temps sans jamais perdre de vue ses passions, qu'il s'agisse de sa collaboration avec les Beastie Boys à son addiction quasi maladive aux NFTs. Même s'il vous dira qu'"être en avance, c'est avoir tort", Ian est toujours à la pointe de l'actualité et possède un sens unique du timing. Son conseil pour réussir ? Faire les choses avec conviction et se concentrer sur l'avenir. Dans cet épisode, Ian partage les tips que lui ont appris ses mentors et ses passages successifs chez Apple Music puis LVMH : Il faut savoir dire non aux bonnes idées pour pouvoir faire ce qui est important (Apple Music) Il faut se concentrer sur les trois points qui vont faire bouger les choses (Tony Belloni, LVMH) La créativité ne suffit pas, il faut aussi être efficace opérationnellement (Bernard Arnault, LVMH) Il faut adapter sa stratégie de communication à la personne que l'on essaye d'atteindre Obsédé par l'avenir, Ian a toujours une longueur d'avance et attend avec impatience le jour où son passeport sera enfin un NFT. Si "vivre dans le futur, c'est tricher", comme il le prétend lui-même, alors il est sacrément doué pour cela ! TIMELINE: 00:15:49 : La carrière de Ian 00:32:28 : Les crypto-monnaies et l'innovation numérique 01:15:43 : L'écosystème et l'économie des NFTs 01:53:50 : L'utilisation des données pour les grands groupes 02:02:45 : Beats, Apple, LVMH et Ledger 02:22:50 : Quitter les réseaux sociaux (sauf Twitter) On a cité avec Ian Rogers plusieurs anciens épisodes de GDIY : #228 - Nicolas Julia - Sorare - Le tsunami français du WEB 3.0 : créer, posséder et échanger du virtuel #229 - Frédéric Montagnon - Arianee - Le WEB3 pour se réapproprier Internet #243 - Eric Larchevêque - Ledger - Le club secret des crypto millionnaires : bitcoin, transmission, savoir et slowlife Ian Rogers vous recommande de lire : The Company, A Short History of a Revolutionary Idea, Adrian Wooldridge and John Micklethwait The KLF: Chaos, Magic and the Band who Burned a Million Pounds, John Higgs Stranger than we can imagine, John Higgs Please Kill Me: The Uncensored Oral History of Punk, Legs McNeil (traduit en français) This is How They Tell me the World Ends, Nicole Perlroth The Emperor of All Maladies, Siddharta Mukherjee (traduit en français) Avec Ian Rogers, on a parlé de : L'épisode #86 de la Martingale avec John Karp sur les NFTs L'épisode #100 de la Martingale avec Jean-Michel Pailhon sur les NFTs “The Solitary Arts” Geoff McFetridge The Beastie Boys Book, Michael Diamond & Adam Horowitz, 2018 CU-SeeMe Compte Twitter : Web3 is going just great A Mashiro The World According to Punk 6529 - Raoul Pal L'exposition Bright Moments Bandcamp PROOF - Kevin Rose Podcast with Matt Kane PROOF - Kevin Rose Podcast with Derek Edward Shloss La conference VeeCon sur le Web3.0 Documentaire The Defiant Ones, 2017 Malle pour skateboard Louis Vuitton x Supreme David Golberg de Yahoo & ex-mari de Sheryl Sandberg The Knowledge Project podcast - episode 68 - Daniel Kahneman Bernard Arnault, LVMH Tim Cook, CEO d'Apple Jake Phelps, Thrasher Magazine Editor Nicolas Julia, fondateur of Sorare Éric Larchevêque, co-fondateur of Ledger Darius Rucker du groupe Hootie and the Blowfish Ian Rogers NFT gallery La musique du générique vous plaît ? C'est à Morgan Prudhomme que je la dois ! Contactez-le sur : https://studio-module.com. Vous souhaitez sponsoriser Génération Do It Yourself ou nous proposer un partenariat ? Contactez mon label Orso Media via ce formulaire. Merci à Olivier Le Garlantezec (Global Digital & Tech Partnerships Director chez LVMH) de nous avoir mis en relation. Si vous aussi vous souhaitez protéger vos cryptoactifs, il n'y a rien de tel qu'un Ledger. Commandez le vôtre dès maintenant en cliquant ici. Pour contacter Ian : Twitter

As a species, we're obsessed with names. They're one of the first labels we get as kids. We name and rename absolutely everything around us. And these names carry our histories, they can open and close our eyes to the world around us, and they drag the weight of expectation and even irony along with them. This week on Radiolab, we've got six stories all about names. Horse names, the names of diseases, names for the beginning, and names for the end. Listen to “Hello, My Name Is” on Radiolab, wherever you find podcasts.  Special thanks to Jim Wright, author of “The Real James Bond” (Bond segment), Tad Davis (reporting help for The Other Robert E. Lee), Cole delCharco (“del-CHAR-ko”) (tape syncer for Horse Names), Peter Frick-Wright, Alexa Rose Miller, Katherine De La Cruz, and Fahima Haque.Members of The Lab, watch for an audio extra on your exclusive feeds, a poem written and read by Mary Szybist, whom Molly Webster interviewed for her story in this episode about endlings. It is titled “We Think We Do Not Have Medieval Eyes.” If you are not yet a member and would like to listen to it, you can join here. Radiolab is on YouTube! Catch up with new episodes and hear classics from our archive. Plus, find other cool things we did in the past — like miniseries, music videos, short films and animations, behind-the-scenes features, Radiolab live shows, and more. Take a look, explore and subscribe!Citations: The Emperor of All Maladies by Siddhartha Mukherjee Warhorse: Cavalry in Ancient Warfare by Philip SidnellCheck out ArtsPractica.com, a site focused on medical uncertainty. Alexa Rose Miller.

Pulitzer-winning physician Siddhartha Mukherjee referred to cancer as “The Emperor of All Maladies.” Now, Mukherjee is one of many contributors to “A New Deal for Cancer – Lessons From A 50 Year War.” This hour on Where We Live, we talk about the legacy and shortcomings of this war, including the lack of access to cancer care for some populations, a byzantine drug reimbursement system, the lack of incentives for preventive testing, and corporatization of physician-owned clinics. We also discuss the promise of President Joe Biden's newly relaunched Cancer Moonshot program, and barriers to its liftoff. The science of cancer has advanced significantly since the National Cancer Act was first signed in 1971. How will the country work towards fewer deaths and equitable treatment for all Americans over the next 50 years? GUESTS:  Abbe R. Gluck: Alfred M. Rankin Professor of Law and Faculty Director, Solomon Center for Health Law and Policy, Yale Law School. Professor of Medicine, Yale School of Medicine. Editor of “A New Deal for Cancer – Lessons From A 50 Year War” Dr. Charles S. Fuchs: Senior Vice President – Global Head of Hematology and Oncology Product Development, Genentech & Roche. Editor of “A New Deal for Cancer – Lessons From A 50 Year War” Giselle Carlotta MacDonald: Executive Director, Project Access-New Haven Support the show: http://wnpr.org/donate See omnystudio.com/listener for privacy information.

Courtney is back and before we jump into discussion of books we've read and liked recently, we discuss how our reading has changed over time.  Download or listen via this link: Reading Envy 238: Inanimate Objects Subscribe to the podcast via this link: FeedburnerOr subscribe via Apple Podcasts by clicking: SubscribeOr listen through TuneIn Or listen on Google Play Or listen via StitcherOr listen through Spotify Or listen through Google Podcasts Books discussed:The Witch's Heart by Genevieve GornichecThe Island of Missing Trees by Elif Shafak The Orchid Thief by Susan OrleanThe Book of Form and Emptiness by Ruth OzekiApple Island: Or the Truth about Teachers by Douglas EvansOther mentions: Washington Black by Esi EdugyanThe Starless Sea by Erin MorgensternPicnic in the Ruins by Todd Robert PetersonThe Gene: An Intimate History by Siddhartha MukherjeeThe Emperor of All Maladies by Siddhartha MukherjeeFive Days at Memorial: Life and Death in a Storm-Ravaged Hospital by Sheri FinkRagnarokNorse Mythology by Neil Gaiman, read by Neil GaimanThe Library Book by Susan OrleanThe Food Explorer by Daniel StoneSeeds of Blood and Beauty by Ann LindsayA Tale for the Time Being by Ruth OzekiThe Bear and the Nightingale by Katherine ArdenAriadne by Jennifer SaintThe Emotional Life of the Toddler by Alicia F. LiebermanThe Anna Karenina Fix: Life Lessons from Russian Literatureby Viv Groskop Related episodes: Episode 179 - Think of the Bees with Courtney BursonEpisode 222 - Minty Fresh with CourtneyStalk us online:Courtney at GoodreadsCourtney is @conservio on LitsyJenny at GoodreadsJenny on TwitterJenny is @readingenvy on Instagram and Litsy All links to books are through Bookshop.org, where I am an affiliate. I wanted more money to go to the actual publishers and authors. I link to Amazon when a book is not listed with Bookshop.

This week, Maureen Taylor, The Photo Detective, is joined by Becca Bender, the Curator, and Archivist of Moving Image and Audio Collections at the Rhode Island Historical Society. The two discuss the necessity of preserving home movies for genealogists, and how movie preservation gives insight into the lives of individuals in the past. Related Episodes:Episode 75: One Man's World War I JourneyEpisode 65: Lost Films Needs Your Help! with Eli SavadaLinks:Sign up for my newsletter.Watch my YouTube Channel.Like the Photo Detective Facebook Page so you get notified of my Facebook Live videos.Need help organizing your photos? Check out the Essential Photo Organizing Video Course.Need help identifying family photos? Check out the Identifying Family Photographs Online Course.Have a photo you need help identifying? Sign up for photo consultation.About My Guest:Becca Bender is the Curator and Archivist of Moving Image and Audio Collections at the Rhode Island Historical Society. She's a deep believer that archives should engage collaboratively with the communities they represent, and that through partnerships we can all work toward creating a more equitable and inclusive historical record. She holds a master's degree from NYU's Moving Image Archiving and Preservation Program and studied Film Production and Africana Studies as an undergraduate at Vassar College. She's an active member of the International Association of Moving Image Archivists and part of a core group of professionals working to improve the preservation of local television news collections across the United States. Prior to becoming an archivist, Becca worked for many years as a documentary archival producer on projects such as the Emmy-nominated PBS series “Black America Since MLK: And Still I Rise” and “Cancer: The Emperor of All Maladies.”About Maureen Taylor:Maureen is a frequent keynote speaker on photo identification, photograph preservation, and family history at historical and genealogical societies, museums, conferences, libraries, and other organizations across the U.S., London and Canada.  She's the author of several books and hundreds of articles and her television appearances include The View and The Today Show (where she researched and presented a complete family tree for host Meredith Vieira).  She's been featured in The Wall Street Journal, Better Homes and Gardens, The Boston Globe, Martha Stewart Living, Germany's top newspaper Der Spiegel, American Spirit, and The New York Times. Maureen was recently a spokesperson and photograph expert for MyHeritage.com, an internationally known family history website and also writes guidebooks, scholarly articles and online columns for such media as Smithsonian.com. Learn more at Maureentaylor.comDid you enjoy this episode? Please leave a review on Apple Podcasts

The World Health Assembly held a Special Session to kickstart a process to draft a global treaty geared towards pandemic management. Priyal Lyncia D'Almeida and Ruturaj Gowaikar discuss the need, scope, and history of such international instruments.Follow Priyal on Twitter: https://twitter.com/lynciapriyalFollow Ruturaj on Twitter: https://twitter.com/ruturajgowaikarListen to our episode on Digital Monitoring of Global Public Health Suggested readings:1. How the world failed to curb COVID 2. Book: Emperor of All Maladies by Siddhartha MukherjeeCheck out Takshashila's courses: https://school.takshashila.org.in/You can listen to this show and other awesome shows on the new and improved IVM Podcast App on Android: https://ivm.today/android or iOS: https://ivm.today/iosYou can check out our website at https://www.ivmpodcasts.com

Least Favorite: Wesley the Owl by Stacey O'brien - Amazon - Goodreads Most Proud of Finishing: The Agony and the Ecstasy by Irving Stone - Amazon - Goodreads Stuck With Me the Most: The Emperor of All Maladies by Siddhartha Mukherjee - Amazon - Goodreads Favorites: A Man Called Ove by Fredrick Backman - Amazon - Goodreads Airborne by Kenneth Oppel - Amazon - Goodreads Atomic Habits by James Clear - Amazon - Goodreads Salt to the Sea by Ruta Sepetys - Amazon - Goodreads

Jeff and Rebecca continue their annual tradition of responding to listener recommendation requests. Follow the podcast via RSS, Apple Podcasts, and Spotify. The show can also be found on Stitcher. This content contains affiliate links. When you buy through these links, we may earn an affiliate commission. Discussed in this episode: How We Got to Now by Steven Johnson Alchemy of Us by Ainissa Ramirez for science history, The Emperor of All Maladies by Siddhartha Mukherjee I Contain Multitudes by Ed Yong Crossroads by Jonathan Franzen The Topeka School by Ben Lerner A Brief History of Nearly Everything by Bill Bryson The Man From the Future by Ananyo Bhattacharya A Small Charred Face by Kazuki Sakuraba The Cheffe by Marie NDiaye Bibliolepsy by Gina Apostol Thursday Murder Club by Richard Osman The Woman Next Door by Yewande Omotoso A Study in Scarlet by Sherry Thomas The Storied Life of AJ Fikry by Gabrielle Zevin A Man Called Ove by Frederick Backman Lillian Boxfish Takes a Walk by Kathleen Rooney Wake Siren by Nina MacLaughlin The Storytelling Animal by Jonathan Gottschall Women Who Run With the Wolves by Clarissa Pinkola Estes The Heroine with 1001 Faces by Maria Tatar Crazy Rich Asians by Kevin Kwan Best American Short Stories City of Girls by Elizabeth Gilbert Such a Fun Age by Kiley Reid The Martian by Andy Weir A Good Walk Spoiled by John Feinstein Harvey Penick's Little Red Book See omnystudio.com/listener for privacy information.

The Emperor of All Maladies by Siddhartha Mukherjee - Amazon - Goodreads Jackie, Ethel, Joan: Women of Camelot by J. Randy Taraborelli - Amazon - Goodreads A Bookshop in Berlin by Francoise Frenkel - Amazon - Goodreads

Ken Burns is an American filmmaker, known for his style of using archival footage and photographs in documentary films. His widely known documentary series include The Civil War (1990), Baseball (1994), Jazz (2001), The War (2007), The National Parks: America's Best Idea (2009), Prohibition (2011), The Roosevelts (2014), The Vietnam War (2017), and Country Music (2019). He was also executive producer of both The West (1996), and Cancer: The Emperor of All Maladies (2015). Burns's documentaries have earned two Academy Award nominations (for 1981's Brooklyn Bridge and 1985's The Statue of Liberty) and have won several Emmy Awards, among other honors.

Enjoy this Curbsiders classic and stay tuned this Wednesday, August 25, 2021 for a brand new CBC Abnormalities Triple Distilled episode. Take a deep dive into common CBC abnormalities. We recorded LIVE at joint grand rounds between Walter Reed NMMC and Uniformed Services University with hematologist, Dr. Mary Kwok MD. Topics include: which parts of the complete blood count (CBC) are most important, interpreting the differential, when to order flow cytometry, who needs a hematology consult and simplified approaches to patients with leukocytosis, leukopenia, erythrocytosis and thrombocytopenia. Episodes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com Credits Written, Produced and Edited by: Matthew Watto MD, FACP Cover Art and Infographic by: Matthew Watto MD, FACP Hosts: Stuart Brigham MD; Matthew Watto MD, FACP; Paul Williams MD, FACP Guest: Mary Kwok MD Sponsor: American College of Physicians acponline.org/100curb ACP CME 100 virtual video package includes 75 hours of practice-changing updates by expert faculty from Internal Medicine Meeting 2021 acponline.org/100CURB. Plus enjoy an exclusive: 25 bonus CME sessions and access until June 1, 2024! Sponsor: Birch by Helix birchliving.com/curb Birch is giving $200 dollars off ALL mattresses and 2 free eco-rest pillows at birchliving.com/curb   Time Stamps* Time Stamps refer to ad-free version 00:00 Intro; Paul shame's the audience; Guest bio 03:17 Guest one-liner, book recommendation* –Emperor of All Maladies (book) by Siddhartha Mukherjee, When Breath Becomes Air (book) by Paul Kalanithi; Career advice -set goals for whatever you're learning. 08:43 Picks of the week: John Wick 3 (film); The Movies That Made Me (podcast) by Joe Dante; The Tim Ferriss Podcast with Julie Rice of Soul Cycle; Infinity Chamber (film) by Travis Milloy 11:50 A case of asymptomatic leukocytosis; Red flags; Repeat the CBC until it's normal 17:30 The peripheral smear; Leukemoid reaction 20:00 The physical exam; When to send flow cytometry? 22:18 A case of lymphopenia; benign ethnic neutropenia; What to look for in the history 27:10 A case of erythrocytosis; Checking EPO levels; JAK2 mutation; Differential Diagnosis; Therapeutic Phlebotomy; Physical findings of Polycythemia Vera 36:53 A case of thrombocytopenia; Lab workup; Differential diagnosis; Pathophysiology; Culprit meds 45:35 Advice for internists 46:36 Take Home Points 47:46 Dr. Kwok's disclaimer 48:10 Outro and post credit scene

The problem with the past is that it's over. How can we enter distant history and understand what happened? Language is one way. Peggy Mohan joins Amit Varma in episode 232 of The Seen and the Unseen to share her insights on what the evolution of our languages reveals about how we got here.  Also check out: 1. Wanderers, Kings, Merchants: The Story of India through Its Languages -- Peggy Mohan. 2. Peggy Mohan's books on Amazon. 3. Amit Varma's Twitter thread on episodes of The Seen and the Unseen about India. 4. Early Indians -- Episode 112 of The Seen and the Unseen (w Tony Joseph). 5. India = Migration -- Episode 128 of The Seen and the Unseen (w Chinmay Tumbe). 6. The Art of Translation -- Episode 168 of The Seen and the Unseen (w Arunava Sinha). 7. The Indianness of Indian Food -- Episode 95 of The Seen and the Unseen (w Vikram Doctor). 8. One Hundred Years of Solitude (Spanish) (English) -- Gabriel García Márquez. 9. Songs of Kabir -- Translated by Arvind Krishna Mehrotra. 10. Essential Kabir -- Translated by Arvind Krishna Mehrotra. 11. I, Lalla: The Poems of Lal Dĕd -- Translated by Ranjit Hoskote. 12. On Language -- Noam Chomsky. 13. The Language Instinct: How the Mind Creates Language -- Steven Pinker. 14. The Baburnama: Memoirs of Babur, Prince and Emperor -- Translated by WM Thackston Jr. 15. Guns, Germs and Steel: Jared Diamond. 16. Punctuated equilibria: an alternative to phyletic gradualism -- Niles Eldredge & Steven Jay Gould. (Also, criticism of it.) 17. Genesis of Ṛgvedic Retroflexion -- Madhav Deshpande. 18. Linguistics, Style and Writing in the 21st Century -- A talk by Steven Pinker. 19. Hindi Nationalism -- Alok Rai. 20. A House Divided: Origin and Development of Hindi/Hindavi -- Amrit Rai. 21. Hindustani Musalmaan - Hussain Haidry. 22. Hum Kagaz Nahin Dikhayenge -- Varun Grover. 23. The Emperor of All Maladies -- Siddhartha Mukherjee. 24. The Song of the Dodo -- David Quammen. 25. The Tangled Tree -- David Quammen. 26. Spillover -- David Quammen. 27. Romila Thapar and Irfan Habib on Amazon. This episode is sponsored by Wondrium. Check out their series, The Story of Human Language. For free unlimited access for 14 days, click here. Please subscribe to The India Uncut Newsletter. It's free! And check out Amit's online course, The Art of Clear Writing.

Nation, welcome back and thank you for tuning in for Episode #071 with our guest Dr. Alan Goldhamer, this is THE episode to share with as many people as you possibly can! There is so much life changing information packed into this podcast, we are calling it the body's “Great Reset”. If you haven't visited us on YouTube please do so, by typing in “Healthcare 360 with Scott E. Burgess” in the search bar, this is where you can view this full episode as well as short deep dives on various topic points pulled from today’s episode. To date, we have over 250 videos posted with valuable content - check it out and remember to give us a thumbs up, hit that subscribe button, share and add a comment to the discussion. Your support and sharing this episode really helps the Nation grow. If you’re an Apple podcast listener, it would mean a lot to the Healthcare360 team if you could take a moment and write us a review, as it really helps out the show! Have a topic to bring to the nation? Head on over to scotteburgess.com and schedule a meeting with me personally, if Instagram is more convenient, you can reach me at my Instagram handle @ScottEBurgess. Now...Let’s jump into our conversation with Dr. Goldhamer! Thank you for listening, and thank you for being a part of the 360Nation. Healthcare360 Host: Scott E. Burgess www.ScottEBurgess.com @ScottEBurgess Burgess@ScottEBurgess.com youtube.com/healthcare360withscotteburgess Healthcare360 Magic Maker: Michelle Burgess MagicMaker@ScottEBurgess.com Guest Contact: Dr. Alan Goldhammer True North Health Center https://www.healthpromoting.com/ Referenced Links: Netflix Series (Un)Well https://www.netflix.com/title/81044208 HC360 #058 Geoffrey Woo https://youtu.be/zHnUesbtKWM HC360 #045 Ben Azadi https://youtu.be/9PputvLIWJk SOS = Salt Oil Sugar Medically Supervised Water Only Fasting and the treatment of hypertension https://www.healthpromoting.com/learning-center/case-studies Rich Roll Podcast: The crazy benefits of fasting interview https://www.richroll.com/podcast/alan-goldhamer-541/ Dr. Shawn Baker on Joe Rogan Experience #1050 https://youtu.be/qnWLUObfPfU The Game Changers (2018) https://gamechangersmovie.com/ HC360 #068 Dr. Tom Cowan https://youtu.be/9NB3e8dfvEU The Contagion Myth by Thomas S. Cowan, M.D. https://drtomcowan.com/products/the-contagion-myth/ The China Study by T. Colin Hamilton Whole by T. Colin Hamilton The Future of Nutrition by T. Colin Hamilton https://www.amazon.com/T.-Colin-Campbell/e/B001K7QPBA?ref_=dbs_p_pbk_r00_abau_000000 HC360 #018 Dr. Chris Davis https://www.scotteburgess.com/podcast-episodes/a-cardiologists-transition-from-reactive-medicine-to-prevention-medicine-with-heather-wright-and-dr-christopher-davis Body Composition changes during fasting https://www.healthpromoting.com/learning-center The Pleasure Trap by Douglas J. Lisle, Alan Goldhamer https://www.amazon.com/The-Pleasure-Trap-audiobook/dp/B07FB6VFF6 Dr. Valter Longo https://www.valterlongo.com/ TrueNorth Health TV https://www.healthpromoting.com/tnhtv/landing True North Foundation 5013C Non Profit https://www.healthpromoting.com/training-for-doctors British Medical Journal https://www.healthpromoting.com/learning-center/article-learning-centers/british-medical-journal-follow-water-only-fasting-and Emperor of All Maladies by Siddhartha Mukherjee https://www.amazon.com/Emperor-All-Maladies-Biography-Cancer/dp/1439170916 Dr. Michael Greger https://nutritionfacts.org/video/the-worlds-largest-fasting-study/ Dr. Tashia Myers https://www.healthpromoting.com/clinic-services/staff/toshia-myers-phd Chef AJ https://www.chefajwebsite.com/index.html Music provided by: IMMEX - Blue Shark https://www.youtube.com/watch?v=r1pmz9IJ1CA Graphic Design by: Waqar Mughal waqarstudio92@gmail.com

Brea and Mallory talk about their 2021 reading resolutions. Email us at readingglassespodcast at gmail dot com!Reading Glasses MerchRecommendations StoreSponsors - Skout’s HonorBabbelCode - GLASSES Links -Reading Glasses Facebook GroupReading Glasses Goodreads GroupAmazon Wish ListNewsletter Libro.fm12 Hour Shift - Where to Watch Books Mentioned - Forget This Ever Happened by Cassandra Rose ClarkeThe Marrow Thieves by Cherie DimalineA Dark and Starless Forest by Sarah HollowellA Black Women’s History of the United States by Daina Ramey Berry and Kali Nicole GrossThe Emperor of All Maladies by Siddhartha MukherjeeI Contain Multitudes by Ed Yong 

For more about Azra, see her website: https://azraraza.com/ The First Cell: And the Human Costs of Pursuing Cancer to the Last is available here: https://www.amazon.com/First-Cell-Human-Pursuing-Cancer/dp/1541699521 Her book with Sara Suleri Goodyear, Ghalib and the Epistemologies of Elegance is available here: https://www.goodreads.com/book/show/7502220-ghalib Her physician profile can be found here: https://cancer.columbia.edu/azra-raza-md Follow Azra on Twitter: @AzraRazaMD Further References George Eliot, Middlemarch: A Story of Provincial Life (1871–2) The complete poems of Emily Dickinson (first published 1890) are available online here: https://www.gutenberg.org/files/12242/12242-h/12242-h.htm Rebecca Skloot, The Immortal Life of Henrietta Lacks (2011) Oscar Wilde, The Ballad of Reading Gaol (1897) Samuel Johnson, The Rambler (1750): https://www.johnsonessays.com/category/the-rambler/ The Crown, “Aberfan” (BBC) Siddhartha Mukherjee, The Gene (2016) and The Emperor of All Maladies (2010) Timestamps Beginning: introduction and Azra reads from The First Cell 6:15 How Azra became interested in medicine and in oncology in particular 14:32 The evolutionary model of cancer’s development in the body 23:50 Cancer and critical systems; the MIST of aging 31:54 Peto’s paradox 41:45 Why cell culture and animal testing methods don’t work 47:41 The immune system, CAR-T treatments, B cells, checkpoint inhibitors 1:00:50 Azra’s personalised approach and how she came to develop it 1:05:59 New, more radical earlier detection methods 1:21:37 The oncology think tank 1:22:48 Monitoring technologies 1:29:32 Azra’s relationship with literature

“Kanker adalah maharaja segala penyakit, raja terror,” demikian kata dr. Siddharta Mukherjee , dokter spesialis dan peneliti kanker terkemuka di dalam bukunya yang terkenal “The Emperor of All Maladies”. Buku ini sudah diterjemahkan ke dalam bahasa Indonesia oleh Rahmat Purwono menjadi “Kanker, Biografi Suatu Penyakit” (Kepustakaan Populer Gramedia, 2020). Yang menarik, bukan saja dr.Mukherjee mengutip berbagai dokter di abad lalu, atau Shakespeare dan Susan Sontag sehingga kanker dikisahkan tak hanya dari sisi medis belaka, tetapi buku setebal 657 halaman ini bercerita dengan naratif tentang sejarah bagaimana manusia mengungkap kanker sejak 4000 tahun silam. Dengan bahasa yang asyik, dan bahasa populer, dr.Mukherjee tetapi juga baga menyatakan bahwakita harus memahami bahwa kanker “bukan satu penyakit, melainkan banyak penyakit.” Menurutnya kesamaan setiap kanker pada organ adalah terjadinya pertumbuhan sel abnormal, tetapi selain itu ‘ada tema-tema budaya dan politis yang mendalam yang meliputi berbagai wujud kanker..” Siapa lagi yang layak membahas buku ini kalau bukan dr.Sp.PD. KHOM Aru Wisaksono Sudoyo. Pengalamannya selama 34 tahun sebagai Hematologist Oncologist ini mengakui betapa buku karya dr Mukherjee tersebut bukan hanya untuk kalangan medis tetapi untuk masyarakat umum untuk memahami apa yang disebut ‘the emperor of all maladies itu. “Buku ini memang sangat layak memperoleh Hadiah Pulitzer tahun 2011 lalu,” demikian dr.Aru. Prof dr @arusudoyo akan membahas buku “Kanker: Biografi Suatu Penyakit” karya Siddhartha Mukherjee ini sekaligus bercerita bagaimana Indonesia menghadapi kanker di masa pandemi di Spotify Rabu 16 September 2020

Harry Paul is a first-year MD-PhD student at Johns Hopkins University. We discuss making medicine a more inclusive environment for all. He can be found on Twitter @_HarryPaul_. Harry's 3 books:1) Educated by Tara Westover2) Between the World and Me by Ta-Nehisi Coates3) The Emperor of All Maladies by Siddhartha Mukherjee

These are very interesting times in which we're living.  I feel the need to leave a record of this behind for my descendants and maybe you do too. Thankfully my two guests are busy collecting and documenting our experiences in a project for the State of Rhode Island. If you live here you can participate. Anyone of any age can add material to the new RI Covid-19 archive. Pictures, stories and video are all being collected.  Link is in the show notes.  In this episode we talk about the roots of this type of digital archive. There is a term for it–Rapid Response archive and one that saves our lived experiences.  It's not new. There have been other rapid response archives for events that have happened in the last several years.You might have a Covid-19 archive in your area. These digital archives are being built by libraries and archives all over the world.Links:Rhode Island Covid-19 archiveSign up for my newsletter.Watch my YouTube Channel.Like the Photo Detective Facebook Page so you get notified of my Facebook Live videos.Need help organizing your photos? Check out the Essential Photo Organizing Video Course.Need help identifying family photos? Check out the Identifying Family Photographs Online Course.Have a photo you need help identifying? Sign up for photo consultation.About My Guests:Kate Wells has served as the Curator of Rhode Island Collections at the Providence Public Library since 2013 after over a decade as an archivist and librarian in university libraries, municipal record collections, and state historical societies across the country. She holds a Master of Arts in History and Master of Library and Information Science from Simmons College. In her current role, she focuses on demystifying the experience of collecting and accessing historic materials through supporting community archives, outreach for creative use of archival collections and utilizing metadata and semantics in access models. Her mission is to facilitate communication, inclusion, and connections to history in order to catalyze social justice and empowerment in communities and cultural heritage organizations.  Becca Bender is the Film Archivist & Curator of Recorded Media at the Rhode Island Historical Society. She holds a master's degree from NYU's Moving Image Archiving and Preservation program, and studied Film Production and Africana Studies as an undergraduate at Vassar College. She's an active member of the international Association of Moving Image Archivists and part of a core group of professionals working to improve preservation of local television news collections across the United States. Prior to becoming an archivist, Becca worked for many years as a documentary archival producer on projects such as the Emmy-nominated PBS series' Black America Since MLK: And Still I Rise and Cancer: The Emperor of All Maladies.  About Maureen Taylor:Maureen is a frequent keynote speaker on photo identification, photograph preservation, and family history at historical and genealogical societies, museums, conferences, libraries, and other organizations across the U.S., London and Canada.  She's the author of several books and hundreds of articles and her television appearances include The View and The Today Show (where she researched and presented a complete family tree for host Meredith Vieira).  She's been featured in The Wall Street Journal, Better Homes and Gardens, The Boston Globe, Martha Stewart Living, Germany's top newspaper Der Spiegel, American Spirit, and The New York Times. Maureen was recently a spokesperson and photograph expert for MyHeritage.com, an internationally known family history website and also writes guidebooks, scholarly articles and online columns for such media as Smithsonian.com. Learn more at Maureentaylor.comDid you enjoy this episode? Please leave a review on Apple Podcasts.

When someone mention cancer, presumably nobody will ask them to introduce the word! Cancer is a term for an aggressive, hard-to-cure disease. People with cancer face not only a huge financial burden but also the fear of looming death. In the United States, 1 in 3 women and 1 in 2 men will develop cancer in their lifetime. Therefore, what exactly is cancer? Can cancer be completely cured? This book, The Emperor of All Maladies, shall reveal these mysteries for you. 

Groundbreaking treatments will improve the lives of millions of people — potentially treating diseases like sickle cell — but there are worries that scientists will take gene-editing technology too far, using it to modify germline DNA in order to enhance certain traits deemed “preferable.” As THE GENE demonstrates, those fears have already been realized: in November 2018, Chinese researcher He Jiankui stunned and horrified the scientific community with an announcement: he had created the first genetically edited babies, twin girls born in China — a medically unnecessary procedure accomplished well before scientists had fully considered the consequences of altering the human genome. “These revolutionary discoveries highlight the awesome responsibility we have to make wise decisions, not just for people alive today, but for generations to come,” says Dr. Mukherjee. “At this pivotal moment when scientists find themselves in a new era in which they’re able to control and change the human genome, THE GENE offers a nuanced understanding of how we arrived at this point and how genetics will continue to influence our fates.” Co-executive produced by filmmaker Ken Burns, the two-part, four hour documentary weaves together science, history and personal stories for a historical biography of the human genome. THE GENE includes interviews with pioneers in the field along with compelling, emotional stories of contemporary patients and their families who find themselves in a desperate race against time to find cures for their genetic diseases, while documenting the thorny ethical questions some of these new treatments raise. Dr. Siddhartha Mukherjee is assistant professor of medicine at the Department of Medicine (Oncology), Columbia University and staff cancer physician at Columbia University Irving Medical Center. He’s also the Pulitzer Prize winning author of Emperor of All Maladies, the definitive work on the history and science of cancer.

Groundbreaking treatments will improve the lives of millions of people — potentially treating diseases like sickle cell — but there are worries that scientists will take gene-editing technology too far, using it to modify germline DNA in order to enhance certain traits deemed “preferable.” As THE GENE demonstrates, those fears have already been realized: in November 2018, Chinese researcher He Jiankui stunned and horrified the scientific community with an announcement: he had created the first genetically edited babies, twin girls born in China — a medically unnecessary procedure accomplished well before scientists had fully considered the consequences of altering the human genome. “These revolutionary discoveries highlight the awesome responsibility we have to make wise decisions, not just for people alive today, but for generations to come,” says Dr. Mukherjee. “At this pivotal moment when scientists find themselves in a new era in which they’re able to control and change the human genome, THE GENE offers a nuanced understanding of how we arrived at this point and how genetics will continue to influence our fates.” Co-executive produced by filmmaker Ken Burns, the two-part, four hour documentary weaves together science, history and personal stories for a historical biography of the human genome. THE GENE includes interviews with pioneers in the field along with compelling, emotional stories of contemporary patients and their families who find themselves in a desperate race against time to find cures for their genetic diseases, while documenting the thorny ethical questions some of these new treatments raise. Dr. Siddhartha Mukherjee is assistant professor of medicine at the Department of Medicine (Oncology), Columbia University and staff cancer physician at Columbia University Irving Medical Center. He’s also the Pulitzer Prize winning author of Emperor of All Maladies, the definitive work on the history and science of cancer.

Cynthia Li, MD, is a physician, author, and speaker. Currently, she has a private practice in integrative and functional medicine, and serves as faculty for the Healer’s Art program at the University of California San Francisco Medical School.  She is author of a new book, Brave New Medicine: A Doctor's Unconventional Path to Healing Her Autoimmune Illness. Dr. Li's first calling was to underserved communities, in settings as diverse as Kaiser Permanente Medical Center's HIV/AIDS division, San Francisco General Hospital, St. Anthony’s Medical Clinic for the homeless, and Doctors Without Borders in rural China. She became interested in evolutionary biology, ancestral health, functional medicine, and the art of intuition while on her own personal health journey -- involving a decade-long "dark night of the soul," in which she developed complex, debilitating conditions that, despite being an expert in chronic diseases, she didn't know how to treat. She was housebound for 2 years. Beyond this physical crisis, there was an existential one: she hadn't believed these kinds of conditions to be real.  She explored, both scientifically and experientially, a wide variety of complementary approaches to Western medicine, including traditional Chinese medicine, mind-body medicine, cranial osteopathy, and whole foods-based nutrition. About 15 years ago, Dr. Li learned she had Hashimoto’s disease, an autoimmune thyroid condition. Following a year of treatment and recurring extreme fatigue, she diagnosed herself with chronic fatigue syndrome and dysautonomia, a dysfunction of the autonomic nervous system, before going to a psychiatrist who recommended (to her dismay) that she see an immunologist.  Dr. Li found herself in the group of patients that either (a) was not recognized or validated by the health community, and/or (b) was not help-able. With no one to decipher her symptoms, Dr. Li became housebound and “went back to basics” to began reading about how chronic disease develops. She recognized that diseases are not defined by a set of criteria but exist instead on a continuum, and she realized that she'd had underlying imbalances for many years, starting out as subtle symptoms that she had either disregarded or pushed beyond. Feeling increasingly motivated, she started exploring the fundamental connection between nourishment and health, including our inextricable spiritual and physical connectedness to our outer world as well as the mysterious inner world of the microbiome-gut microorganisms, with which we have co-evolved for millennia. She dove deeper into how gene expression is affected by what we eat, drink, breathe, think, believe, and how we move our bodies, and experimented with integrative medicine, acupuncture, herbs, and mind-body medicine. Dr. Li later learned about functional medicine, which she describes as an important turning point, giving her hope both as a patient and as a doctor.  Yet even then, she had such little energy that it was easy for her to have “hope fatigue.” Instead of trying to think positively or be optimistic all the time, she learned to release the tremendous grief and shame she was carrying through attending a grief ritual. “As a side effect, what ends up filling up that space is health,” she says.  She eventually returned to clinical practice, but with a very different set of eyes: one that saw the beautiful complexity of the body, mind, and spirit; and what it looks like when that wholesome balance is disturbed. In her memoir, Brave New Medicine, Dr. Li details the disabling autoimmune illness that forced her to question her medical training, embrace the principles of integrative and functional medicine, and unlock her body’s innate potential to heal. Challenging contemporary medical norms and drawing upon cutting-edge science, ancient healing arts, and the power of intuition to offer a fresh, new perspective for doctors and patients alike, she also explores what healthcare might look like if doctors had an immersion in wellness: “Would we have that experience to be able to translate to our patients?” Experiencing “autoimmunity changed my practice of medicine,” she says. Dr. Siddhartha Mukherjee, doctor and Pulitzer Prize–winning author of The Emperor of All Maladies, says that “Li’s writing is so intimate — and so exacting — that it cuts like a knife. She raises fundamental questions about the future of medicine, her own future, and about being a doctor and a patient at the same time. The result is a beautiful book that will be read and remembered for years to come.”  Anne Lamott, New York Times bestselling author of Bird by Bird, and Almost Everything: Notes on Hope, describes Brave New Medicine as “a harrowing and somehow also charming account by a brilliant doctor of how she healed her body, mind, spirit and soul from a debilitating autoimmune disease. After her doctors had given up on her, with a husband and two little children at home, she broke out of the constraints of Western medicine, and found her way home to health, renewal, and her own true self. This beautifully written prescriptive book is going to change and even save people’s lives.”  Dr. Michael Lerner describes the book as a “memoir for our time.” Dr. Li a member of the American Board of Internal Medicine, the Institute for Functional Medicine, and Integrative Medicine for the Underserved (IM4US). She is a contributor to Huffington Post’s Thrive Global and Psychology Today.  She lives in Berkeley, CA with her husband, 2 daughters, their dog, a hamster, and 50,000 honeybees. She enjoys gardening, urban farming, traditional cooking, playing the piano and ukulele, reading, hiking, and camping. To stay grounded and balanced, she practices Wisdom Healing Qigong every day. Join us in conversation with this gifted scientist and healer!

Leah discusses one of her favorite books, "The Ghost Map" by Steven Johnson. Also included are read-alikes, TV shows, and movies with a similar theme. Here's everything we talked about in the episode: Books mentioned: "The Ghost Map" by Steven Johnson. "The Emperor of All Maladies" and "The Gene" by Siddhartha Mukherjee. "Rabid" by Bill Wasik. "Pale Rider" by Laura Spinney. "Dr. Mütter's Marvels" by Cristin O'keefe Aptowicz. "Hospital Sketches" by Louisa May Alcott. TV shows and movies mentioned: Botched, E! Entertainment Nip/Tuck, FX Scrubs, NBC / ABC Grey’s Anatomy, ABC The Good Doctor, ABC Chicago Med, NBC Carriers (2009), Director David Pastor Contagion (2011), Director Steven Sonderbergh 12 Monkeys (1995), Director Terry Gilliam Pandemic (2016), Director John Suits Outbreak (1995), Director Wolfgang Petersen Check out books, movies, and other materials through the Milwaukee County Federated Library System: countycat.mcfls.org www.hoopladigital.com wplc.overdrive.com oakcreeklibrary.org

Siddhartha Mukherjee, physician, researcher, and author of the 2011 Pulitzer-Prize winning book The Emperor of All Maladies, discusses what we know about how coronavirus spreads and what we don’t know. Plus, he offers advice on canceling travel plans.  Learn more about your ad choices. Visit podcastchoices.com/adchoices

This week Alice and Kim highlight 50 awesome nonfiction books to celebrate their 50th episode! This episode is sponsored by Get Booked from Book Riot, Me and White Supremacy from Sourcebooks, and Book Riot Insiders. Subscribe to For Real using RSS, Apple Podcasts, Spotify, or Stitcher. For more nonfiction recommendations, sign up for our True Story newsletter, edited by Alice Burton. Books Mentioned Bad Blood by John Carreyrou Building a Life Worth Living by Marsha M. Linehan The Boys in the Boat by Daniel James Brown Unfollow by Megan Roper Phelps The Art of Choosing  by Sheena Iyengar A Woman’s Crusade by Mary Walton The Great Beanie Baby Bubble by Zac Bissonnette  Meaty by Samantha Irby The Poisoner’s Handbook by Deborah Blum Moonbound by Jonathan Fetter-Vorm Without You There Is No Us by Suki Kim Men Explain Things to Me by Rebecca Solnit Stiff by Mary Roach Spare Parts by Joshua Davis Word Freak by Stefan Fatsis  King Mob by Christopher Hibbert When Breath Becomes Air by Paul Kalanithi The Orchid Thief by Susan Orlean Educated by Tara Westover My Squirrel Days by Ellie Kemper Assassination Vacation by Sarah Vowell Portage by Sue Leaf  White Fragility by Robin DiAngelo My Own Devices by Dessa  All You Can Ever Know by Nicole Chung The Distraction Addiction by Alex Soojung-Kim Pang Crash Override by Zoe Quinn How Star Wars Conquered the Universe by Chris Taylor The Last Black Unicorn by Tiffany Haddish The Power of Meaning by Emily Esfahani Smith Never Caught by Erica Armstrong Dunbar The Emperor of All Maladies by Siddhartha Mukherjee  They Can’t Kill Us All by Wesley Lowery From the Corner of the Oval by Beck Dorey-Stein American Heiress by Jeffrey Toobin Good Talk by Mira Jacob Political Tribes by Amy Chua The Empathy Exams by Leslie Jamison Amateur by Thomas Page McBee Knocking on Heaven’s Door by Katy Butler We Should All Be Feminists by Chimamanda Ngozi Adichie Leaving Orbit by Margaret Lazarus Dean The Ridiculous Race by Steve Hely and Vali Chandrasekaran Five Days at Memorial by Sheri Fink Mayflower by Nathaniel Philbrick Another Day in the Death of America by Gary Younge I’ll Be Gone in the Dark by Michelle McNamara This Life is In Your Hands by Melissa Coleman The Sixth Extinction by Elizabeth Kolbert Reset by Ellen Pao

Cold Outreach - Seriously... is there anything worse than that feeling when you’re about to send an unsolicited message to someone you admire or want to connect with to find work? “I’m probably bothering them.” “They’re too busy to pay attention to me.” “I feel weird asking strangers for help.” “I probably sound desperate.” “Why even bother? Nobody ever responds anyway.” There’s no question that if done wrong, outreach messages can be a surefire path to rejection, isolation, complete lack of confidence, and feeling like you have no way to connect to the right people that can potentially become your mentors, colleagues, or collaborators. But when done correctly, A well-written outreach message can change your entire career. In today’s interview I chat with Scott Davis who considers himself to be a “hopeless introvert.” As someone who recently made the major career transition from working in documentaries in New York City to working in scripted features in Los Angeles, Scott will be the first to tell you how overwhelming it can feel to have to rebuild your network from the ground up. But with the right mindset, the right strategies, and a little support, Scott’s new career in Los Angeles is not only surviving but thriving. Want to Hear More Episodes Like This One? » Click here to subscribe and never miss another episode Here's What You'll Learn: Scott’s ‘origin story’ from New York to Hollywood with no connections and ‘no idea what to do’ (sound familiar?) The terrifying feeling of trying to get into this ‘fortress of opportunity’ in Hollywood where the only way in seems to be from people inside who are working & too busy to help you. The dilemma of just 'finding the next gig to pay the bills' vs. ‘playing the long game’ to pursue the career path you really want. The counter-intuitive shift in focus that makes that effectively eliminates that so-called ’dilemma’. (Listen for this key takeaway!) Why there’s no more important skill than networking in this industry and the step-by-step path to networking for introverts. Discover the ’secrets’ to “cold emailing” / “cold outreach” and how Scott boosted his response rate from 5% to 75%. The REAL goal of sending an outreach email. (HINT: It sounds so easy it couldn’t possibly work.) How to ‘crawl inside the brain’ of the person you send an outreach email to and see it from their perspective. How to get people to OPEN your approach email and why doing a few minutes of research goes a LONG way. Why the idea of “nobody wants to help me” is just wrong and right way to tap into people’s natural tendency to WANT share their wisdom & experience with you. Connecting the dots: Scott’s story of turning rejections into opportunities. What it really means to “lead with value” and the power of ‘validation’. The momentum that builds when you invest in building relationships over time. If you’re inspired by Scott’s journey today and you’d like to up your networking game, specifically your outreach emails, then you’re in luck. Because I’m just finishing up something brand new called ‘The Insider’s Guide to Writing Great Outreach Emails’ and as a loyal listener you’ll get first dibs. In this guide I’m going to break down the process of writing outreach emails so you understand EXACTLY what will get you a response. I’ll teach you why cold outreach is the most important soft skill you must develop if you want to advance your career, I’ll show you the 5 most common mistakes people make when writing their outreach messages, and then I’ll break down step-by-step how to write an amazing outreach message that will actually get a response so you can seek advice, connect with a potential mentor, set up lunch meetings, and possibly even land your next gig. Download this brand new guide for FREE And for those of you interested in working with me for the next 12 weeks and beyond in my coaching & mentorship program, enrollment is open until January 26th. If you’d like to learn more and apply please visit https://optimizeyourself.me/optimizer Useful Resources Mentioned: ‘The Insider’s Guide to Writing Great Outreach Emails’ My Coaching & Mentorship Program Scott's Website Scott on IMDB Contact Scott Our Generous Sponsors: This episode is made possible for you by Ergodriven, the makers of the Topo Mat, my #1 recommendation for anyone who stands at their workstation. The Topo is super comfortable, an awesome conversation starter, and it’s also scientifically proven to help you move more throughout the day which helps reduce discomfort and also increase your focus and productivity. Click here to learn more and get your Topo Mat. Guest Bio: J. Scott Davis is an editor, assistant editor, outdoorsman, hopeless introvert and constant seeker of knowledge. "I lived and worked in NYC for over 10 years working with some of the greatest documentarians on some really great films like: “Makers: The Women Who Make America”, “Cancer: The Emperor of All Maladies”, “Wagner’s Dream” and “Outside the Bubble”. In the fall of 2018 I headed west to Los Angeles to escape bad weather, lack of sunlight, and 5th floor walk ups. The lifestyle change is glorious but the true joy is I am now pursuing a long held dream of working in scripted features and series." Scott's Website Scott on IMDB Contact Scott Show Credits: This episode was edited by Curtis Fritsch, and the show notes were prepared and published by Glen McNiel. The original music in the opening and closing of the show is courtesy of Joe Trapanese (who is quite possibly one of the most talented composers on the face of the planet). Note: I believe in 100% transparency, so please note that I receive a small commission if you purchase products from some of the links on this page (at no additional cost to you). Your support is what helps keep this program alive. If you have any questions, please don’t hesitate to contact me.

This week Alice and Kim take a trip down memory lane to talk about books that appeared on best of the decade lists.  This episode is sponsored by Book Riot's Read Harder Journal, Book Riot's Read Harder 2020 Challenge, and Book Riot's Tailored Book Recommendations. Subscribe to For Real using RSS, Apple Podcasts, Spotify, or Stitcher. For more nonfiction recommendations, sign up for our True Story newsletter, edited by Kim Ukura. Follow Up In the Dream House by Carmen Maria Machado New Books A Crisis of Peace: George Washington, the Newburgh Conspiracy, and the Fate of the American Revolution by David Head America for Americans: A History of Xenophobia in the United States by Erika Lee Best Books of the Decade Paste Magazine: The 25 Best Memoirs of the 2010s LitHub: The 20 Best Works of Nonfiction of the Decade Time: The 10 Best Nonfiction Books of the 2010s Entertainment Weekly: Here are EW's top 10 nonfiction books of the decade The Immortal Life of Henrietta Lacks by Rebecca Skloot When Breath Becomes Air by Paul Kalanithi The Sixth Extinction by Elizabeth Kolbert The Emperor of All Maladies by Sidhartha Mukherjee All the Single Ladies by Rebecca Traister The Warmth of Other Suns by Isabel Wilkerson The New Jim Crow by Michelle Alexander Men We Reaped by Jesmyn Ward I’ll Be Gone in the Dark by Michelle McNamara Dark Money by Jane Mayer Reading Now Guest House for Young Widows by Azadeh Moaveni 

In 2017, opioid addiction claimed nearly 50,000 American lives—that’s as many Americans as were lost in the entire Vietnam War, and more than were lost to gun-shots and automobile accidents combined.  Dr. John Halpern and David Blistein explore the history of opium—from antiquity to the modern world—and describe a solution to the opioid crisis that blends an understanding of what works and what has failed, previously.  Halpern and Blistein are the coauthors of “Opium: How an Ancient Flower Shaped and Poisoned Our World,” which details the history of opium and its evolution to the opioid crisis that ravages our nation today.  Halpern is a private-practice psychiatrist who previously served as medical director of the Boston Center for Addiction Treatment, the largest substance-use disorder hospital in New England.  He completed his residency and fellowship in addiction research at Harvard Medical School programs and taught at Harvard Medical School for over 20 years. Blistein is the author of the award-winning PBS documentary “The Mayo Clinic: Faith–Hope–Science” and is currently writing a comprehensive, three-part series on brain disorders and mental health.  He co-wrote “Cancer: The Emperor of All Maladies” and “The Gene” for PBS and authored “David’s Inferno,” which combines personal anecdotes with insights into the diagnosis and treatment of manic-depression.

امپراطور همه‌ی بیماری‌ها (The Emperor of All Maladies) سرطان برای خیلی‌ها تلخ‌ترین کلمه‌ی این دنیاست. این کتاب اما اصلا کتاب تلخی نیست. پیشرفت‌هایمان را نشان می‌دهد درباره‌ی شناخت و درمان سرطان.            نویسنده: سیدارتا موکرجی متن: عباس سیدین | روایت: علی بندری | تدوین: امید صدیق‌فر کتاب‌های بی‌پلاس را از اینجا  بخرید. پشتیبان بی‌پلاس شوید. موزیک‌ها : حسین نجفی| Lee Rosevere اسپانسر‌ها:  لست سکند | اینستاگرام لست سکند | کانال تلگرام لست سکند پچ‌پچ | اینستاگرام پچ پچ ثبت‌نام در اپلیکیشن خلاصه‌ی کتاب بلینکیست عضویت در خبرنامه  

All Access is taking you back to Chicago and is bringing you the Admissions Team from the University of Chicago Pritzker School of Medicine.  The Associate Dean AND Director of Admissions get in on the conversation along with a current medical student.  You will hear the student perspective along with some insight into the value of medical students in the admissions process.  We touch on a lot of issues and advice that can be applicable to a lot of medical school admissions processes.  Have a question for the show? Send it to allaccess@case.edu Visit https://case.edu/medicine/allaccess for more information on this episode and others. Resources: University of Chicago Pritzker School of Medicine Scholarship & Discovery Student-Run Free Clinics Their Recommendations: Dr. Carter's:  Read books about the patients they are serving in their communities! The Warmth of Other Suns by Isabel Wilkerson In this epic, beautifully written masterwork, Pulitzer Prize–winning author Isabel Wilkerson chronicles one of the great untold stories of American history: the decades-long migration of black citizens who fled the South for northern and western cities, in search of a better life. Emily's: The Emperor of All Maladies by Siddhartha Mukherjee   Winner of the Pulitzer Prize, and now a documentary from Ken Burns on PBS, The Emperor of All Maladies is a magnificent, profoundly humane “biography” of cancer. Balaji's:  Educated by Tara Westover Educated is an account of the struggle for self-invention. It is a tale of fierce family loyalty and of the grief that comes with severing the closest of ties. Podcast:  Revisionist History by Malcolm Gladwell.   Contact:  pritzkeradmissions@bsd.uchicago.edu

Alex is a prolific composer whose film scores have premiered at festivals around the world including Sundance, Berlinale, Venice, and Slamdance. Alex recently scored Lulu Wang's acclaimed The Farewell, the suspenseful drama, The Last Supper for David Wexler, and H. for Daniel Garcia and Rania Attieh. Alex's music has also been featured on projects including Jane Fonda in Five Acts for HBO, and the documentary Cancer: The Emperor of All Maladies for PBS.

Dr. Renee Marinelli has Dr. Sahil Mehta on the line today to discuss an interventional radiology case that he has experienced. It teaches us about medicine, its implications, and how we treat patients throughout the years. [0:57] The start of the case. Dr. Mehta came across this case as an intern before he knew anything about interventional radiology. He was presented with a woman who had dyspnea on exertion. [2:39] Dr. Mehta’s evaluation. She had been progressively losing her breath over the course of three weeks, prompting her to finally seek care. Her medical history was really interesting; she had been diagnosed with Hodgkin's lymphoma at seventeen-years-old and was around fifty years older now. She had gotten radiation therapy to treat this, which caused several complications later in life. [8:26] Going through her records. The patient brought all of her medical records with her, and Dr. Mehta had to sort through them for necessary information. It was a lot of work and took a few days. [10:21] Narrowing down the causes of her current issue. Like anything else in medicine, there was a checklist that had to be gone through. The doctors initially believed that may have had pneumonia, but antibiotics did not help so they had to dig deeper. Eventually, a CT scan was ordered, and SVC syndrome was discovered. [14:33] Takeaways from this case. Dr. Mehta says the real takeaway is the consequences of medical treatment that we don’t know about. There are things we can look back on from decades ago that we think are crazy but were tested and accepted at the time. The same thing might happen decades from now. [16:48] Dealing with public distrust of medicine. Stay humble and realize that we don’t have all the answers. We work with the best of our knowledge and capabilities. [21:58] Weighing risks and benefits. There is always a weighing of risks and benefits in medicine. Radiation therapy was quite new when this patient had received it, but we still use it today to treat cancer. [25:08] Closing thoughts. It’s important to remember that we can learn something from every single patient we meet. The Emperor of All Maladies: https://www.amazon.com/Emperor-All-Maladies-Biography-Cancer/dp/1439170916

Take a deep dive into common CBC abnormalities. We recorded LIVE at joint grand rounds between Walter Reed NMMC and Uniformed Services University with hematologist, Dr. Mary Kwok MD. Topics include: which parts of the complete blood count (CBC) are most important, interpreting the differential, when to order flow cytometry, who needs a hematology consult and simplified approaches to patients with leukocytosis, leukopenia, erythrocytosis and thrombocytopenia.  Full show notes at https://thecurbsiders.com/podcast. Join our mailing list and receive a PDF copy of our show notes every Monday. Rate us on iTunes, recommend a guest or topic and give feedback at thecurbsiders@gmail.com. Credits Written, Produced and Edited by: Matthew Watto MD, FACP Cover Art and Infographic by: Matthew Watto MD, FACP Hosts: Stuart Brigham MD; Matthew Watto MD, FACP; Paul Williams MD, FACP Guest: Mary Kwok MD   Sign Up for a course w/our Chief of POCUS, Dr. Renee Dversdal! ACP - acponline.org/pocus AIUM - Check out https://aium.org for upcoming events.  TRUST (Train the Ultrasound Trainers) https://www.ultrasoundtraining.com.au/courses/category/train-the-ultrasound-trainer-trust Time Stamps 00:00 Intro; Paul shame’s the audience; Guest bio 03:17 Guest one-liner, book recommendation* -Emperor of All Maladies (book) by Siddhartha Mukherjee, When Breath Becomes Air (book) by Paul Kalanithi; Career advice -set goals for whatever you’re learning. 08:43 Picks of the week: John Wick 3 (film); The Movies That Made Me (podcast) by Joe Dante; The Tim Ferriss Podcast with Julie Rice of Soul Cycle; Infinity Chamber (film) by Travis Milloy 11:50 A case of asymptomatic leukocytosis; Red flags; Repeat the CBC until it’s normal 17:30 The peripheral smear; Leukemoid reaction 20:00 The physical exam; When to send flow cytometry? 22:18 A case of lymphopenia; benign ethnic neutropenia; What to look for in the history 27:10 A case of erythrocytosis; Checking EPO levels; JAK2 mutation; Differential Diagnosis; Therapeutic Phlebotomy; Physical findings of Polycythemia Vera 36:53 A case of thrombocytopenia; Lab workup; Differential diagnosis; Pathophysiology; Culprit meds 45:35 Advice for internists 46:36 Take Home Points 47:46 Dr. Kwok’s disclaimer 48:10 Outro and post credit scene

Notes from the Show: -Rehan Choudhry's website | instagram -Emerge Festival -His wife Jessica Moore -The Killers: Land of The Free -A Beautiful Perspective -Devotion by Dani Shapiro -How Democracies Die by Steven Levitsky -Educated by Tara Westover -The Emperor of All Maladies by Siddhartha Mukherjee Emerge Artists Mentioned: -Brandon Flowers (The Killers) performed Land of The Free -Jose Antonio Vargas -Big Freedia -Laura Jane Grace -Jonathan and Paula Williams -Yoke Lore - Good Pain -Gerard Way -Rob Cavallo Likes & Learns: -Pop Rocket Podcast  -Busy Tonight  -Glowing Up Podcast -Wear Sunscreen (Learn) All original music composed by Carolyn Pennypacker Riggs Album art by Zoie Harman Cool Things to Check-Out: -Read my latest piece for The Fullest Is Self-Care Draining Your Bank Account? -Previous podcast guest Clara Artschwager and I are hosting an event July 17th from 7-9pm at The Hoxton in Williamsburg. I will be teaching a yoga class and Clara will talk us through her approach to dating and relationships. Tickets are $15 and you can get them here. -My journaling class with Bluprint is now live and I am so excited to share it with you guys! I love Bluprint and their commitment to creative education. They're actually hosting a Blupruint Cruise (!!!) next year that sounds like SO MUCH FUN. Click here to learn more about the cruise. -Sign-up for my newsletter to get updates on where I’ll be and what I’m loving. –Join the listener Facebook Group. -Get my book Let It Out: A Journey Through Journaling. If you Liked This Episode Try Out: -Episode 222 with Trevor Hall -Episode 160 with Misty Boyce This week’s episode is sponsored by Ned. Ned offers wonderful hemp products made from organic materials in small batches to help with anxiety and insomnia relief, natural pain relief, as an anti-inflammatory, and so much more . I have tried so many CBD products but Ned is one of the best! They extract their oils from hemp flowers using a slow and mindful process, and infuse each batch with binaural beats and happy loving energy. I love that on their dosage instructions on the bottle it reminds me to take 3 deep breaths before using. It’s such a grounding process and I’m so excited to share their wonderful products with Let It Out Listeners. Ned is offering 15% off and FREE SHIPPING with our link and by entering code LETITOUT at checkout

In this episode, Siddhartha Mukherjee, oncologist, researcher, and author of the Pulitzer Prize-winning book “The Emperor of All Maladies: A Biography of Cancer,” discusses his writing process, his thoughts about medicine, cancer, immunotherapy, and his recent collaboration on a study combining a ketogenic diet with a drug in mice that provided remarkable and encouraging results. We discuss: Sid’s background [5:00]; How Sid and Peter met [6:00]; Sid’s Pulitzer Prize-winning book: The Emperor of All Maladies [8:00]; Sid’s writing process: the tenets of writing [12:30]; Our struggle to find preventable, human, chemical carcinogens of substantial impact [23:30]; The three laws of medicine — Law #1: A strong intuition is much more powerful than a weak test [26:30]; Law #2 of medicine: “Normals” teach us rules; “outliers” teach us laws [32:00]; Law #3 of medicine: For every perfect medical experiment, there is a perfect human bias [35:00]; The excitement around immunotherapy [38:15]; The story of Gleevec [46:00]; How does the body's metabolic state affect cancer? [49:30]; Can a nutritional state be exploited and/or a drug sensitivity be exploited through a nutritional intervention? [52:00]; How does Sid balance his family, writing, research, laboratory, and patients? [1:00:30]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.

Jeff and Rebecca wrap up their 2018 holiday recommendations. This episode is sponsored by: Fight Like a Girl by Clementine Ford Wizard Pins Penguin Random House Audio's Holiday Guide Books recommended in this episode: The Broken Earth Trilogy by N.K. Jemisin Pere Giorot by Balzac Incarceration Nations by Baz Dreisinger The Emperor of All Maladies or The Gene Naked at Lunch The Noble Hustle by Colson Whitehead The Feather Thief by Kirk Wallace Johnson Josh and Hazel’s Guide to Not Dating by Christina Lauren The Kiss Quotient by Helen Hoang Fit by Rebekah Weatherspoon The Nest by Cynthia d'Aprix Sweeny Pachinko by Min Jin Lee Beverly Jenkins romances The Killer Angels by Michael Shaara SPQR by Mary Beard Long Division by Kiese Laymon The Shining Girls by Lauren Beukes Music for Wartime Time and Again by Jack Finney The Night Circus by Erin Morgenstern Silver Sparrow by Tayari Jones Wedding Toasts I’ll Never Give How to Be Married The H-Spot by Jill Filopvic Educated by Tara Westover Heavy by Kiese Laymon Killing It by Camas Davis Negroland by Margo Jefferson Sapiens by Yonah Nuval Harari Saga by Vaughn and Staples Gridiron Genius by Mike Lombard The Console Wars

In Episode 34, Quinn & Brian discuss: Electrocuting the S#!t Out of Cancer. Our guest is Theo Roth, an MB/PhD student candidate at UCSF who spends his days running experiments in the Marson Lab, and contributing to kick-ass research like the development of new tools for efficient CRISPR genome engineering in human cells. The topic of this episode is extremely close to us and particularly relevant right now because September is Childhood Cancer Awareness Month. Childhood cancer, unfortunately, only receives 5% of the total federal research funding, which means we need more people like us supporting cancer researchers and hospitals that are working to help children with cancer. So our goal with this episode is to not only explain all of the awesome work that Theo does and how in the hell he electrocutes cancer cells – although we definitely get all up in that – but also to identify some steps you can take RIGHT NOW to support people like Theo who are fighting the good fight and working to eliminate cancer. On that note: f#$k cancer in the face. Want to send us feedback? Tweet us, email us, or leave us a voice message! Trump’s Book Club: The 8th Day of Creation by Horace Freeland Judson Links: Support Sloan Kettering Cancer Center Support Alex’s Lemonade Stand Learn more about Marson Lab: marsonlab.ucsf.edu The Emperor of All Maladies by by Siddhartha Mukherjee Seven Brief Lessons on Physics by Carlo Rovelli Watch: The Knick Sign up for Nature’s email newsletter Sign up for STAT’s newsletters Read: "Why Daydreaming is Good for Us" Connect with us: Support this podcast

For our first Narrative Medicine Rounds for Fall 2018, we welcome Dr. Haider Warraich, whose book Modern Death deepens and enriches the conversation about death and dying that’s been growing since Dr. Sherwin Nuland’s classic How We Die: Reflections on Life’s Final Chapter and Atul Guwande’s Being Mortal: Medicine and What Matters in the End. About the book, which was published last year by St. Martin’s Press, Siddhartha Mukherjee, who is the author of The Emperor of All Maladies and The Gene, and an assistant professor of medicine at Columbia University, writes: “Haider Warraich’s elegant and poignant book takes us on an unforgettable journey. A caring and thoughtful doctor, he also writes beautifully. He succeeds in humanizing a complex topic and gives us remarkable insights about the changing nature of ‘modern death.’” Dr. Warraich, who graduated from medical school in Pakistan in 2009, did his residency in internal medicine at one of Harvard Medical School's main teaching hospitals, Beth Israel Deaconess Medical Center. He is currently a fellow in cardiology at Duke University Medical Center. His medical and Op Ed pieces have appeared in many media outlets including the New York Times, The Atlantic, the Wall Street Journal, Slate, and the LA Times among others.

This week, Liberty discusses The Black Count, The Noble Hustle, Autobiography of a Face, and more great older books. Sign up for the weekly New Books! newsletter for even more new book news. Books discussed on the show: I'll Be Gone in the Dark by Michelle McNamara The Cadaver King and The Country Dentist by Radley Balko and Tucker Carrington Five-Finger Discount by Helene Stapinski The Black Count by Tom Reiss The Noble Hustle by Colson Whitehead Autobiography of a Face by Lucy Grealy Truth and Beauty by Ann Patchett Full-Body Burden by Kristen Iversen Emperor of All Maladies by Siddhartha Mukherjee Another Bullshit Night in Suck City by Nick Flynn James Tiptree Jr.: The Double Life of Alice B. Sheldon by Julia Phillips Hammer Head by Nina MacLaughlin Clandestine in Chile by Gabriel Garcia Marquez The Skies Belong to Us by Brendan Koerner Dipper and Mabel's Guide to Mystery by Rob Renzetti and Shane Houghton

Siddhartha Mukherjee is a cancer specialist. His biography of the disease, The Emperor of All Maladies, won the Pulitzer Prize in 2010. A haematologist and oncologist by training, his research focuses on cancer therapy and gene functions related to blood cells. His latest book, The Gene, goes in search of normality, identity, variation and heredity. Born in India in 1970 he grew up with his extended family in Delhi. In his youth he trained as an Indian classical singer before travelling to the US to study biology at Stanford. At Oxford he was a Rhodes scholar before enrolling at Harvard to study medicine. He is currently Assistant Professor of Medicine at the Columbia University Medical Centre.Presenter: Kirsty Young Producer: Cathy Drysdale.

Siddhartha Mukherjee is a cancer specialist. His biography of the disease, The Emperor of All Maladies, won the Pulitzer Prize in 2010. A haematologist and oncologist by training, his research focuses on cancer therapy and gene functions related to blood cells. His latest book, The Gene, goes in search of normality, identity, variation and heredity. Born in India in 1970 he grew up with his extended family in Delhi. In his youth he trained as an Indian classical singer before travelling to the US to study biology at Stanford. At Oxford he was a Rhodes scholar before enrolling at Harvard to study medicine. He is currently Assistant Professor of Medicine at the Columbia University Medical Centre. Presenter: Kirsty Young Producer: Cathy Drysdale.

On today's episode, Jill is joined by newcomer Kristi as they discuss some of their favorite nonfiction titles. They dive into some fascinating conversations about travel, science and much more while also providing some helpful "introductory" titles for people looking to get into nonfiction books for the first time. All titles discussed can be sampled and borrowed by clicking on them in the list below. Nonfiction Reads   Romantic Outlaws by Charlotte Gordon   This is Not My Life by Diane Schoemperlen   Dreamland by Sam Quinones   Cracking the Cube by Ian Scheffler   The Paradox of Choice by Barry Schwartz   A Walk in the Woods by Bill Bryson   In a Sunburned Country by Bill Bryson   At Home by Bill Bryson   Lady Almina and the Real Downton Abbey by The Countess of Carnarvon   The Devil in the White City by Erik Larson   Thunderstruck by Erik Larson   Dead Wake by Erik Larson   The Six Wives of Henry VIII by Alison Weir   The Gene by Siddhartha Mukherjee   The Emperor of All Maladies by Siddhartha Mukherjee   Stiff by Mary Roach   Grunt by Mary Roach   The Best American Science and Nature Writing 2016 by Amy Stewart and Tim Folger   The Cabaret of Plants by Richard Mabey   Surely You're Joking, Mr. Feynman! By Richard Feynman   The Immortal Life of Henrietta Lacks by Rebecca Skloot   Blood in the Water by Heather Ann Thompson   Patient H.M. by Luke Dittrich   Pistols at Dawn by John Campbell   Say Hello! Find OverDrive on Facebook at OverDriveforLibraries and Twitter at @OverDriveLibs. Email us directly at feedback@overdrive.com    Music "Buddy" provided royalty free from www.bensound.com   Podcast Overview We're not just book nerds: we're professional book nerds and the staff librarians who work at OverDrive, the leading app for eBooks and audiobooks available through public libraries and schools. Hear about the best books we've read, get personalized recommendations, and learn about the hottest books coming out that we can't wait to dive into. For more great reads, find OverDrive on Facebook and Twitter.  

Cancer is like a computer program gone wrong, the kernel panic of the human body. Unfortunately, we have no reboot button, and so cancer is the most serious of diseases. This year, almost six hundred thousand Americans will die from cancer. Despite the fact that cancer receives more NIH funding than any other illness, the death rates remain the same as in the 1950s. Tripping Over the Truth: The Return of the Metabolic Theory of Cancer tells the story of molecular biologist and science writer Travis Christofferson’s journey to discover why cancer has remained so elusive. The central theme of the book is that we’ve fundamentally mischaracterized the origin of cancer. Most scientists hold to the belief that cancer is a genetic disease, Travis explores the idea that cancer is, in fact, a disease of damaged metabolism. The metabolic theory of cancer stems from Nobel laureate Otto Warburg’s observation in 1924 that cancer cells lack the ability to produce energy using anything other than an ancient and inefficient process of fermentation. Warburg’s idea failed to gain critical mass, and by the 1960s had largely faded into oblivion. In 2012, Thomas Siegfried, Ph.D., released his book Cancer as a Metabolic Disease where he expanded on Warburg’s original hypothesis. In his book, Siegfried described how all cancer cells have damaged mitochondria, the organelle responsible for creating energy with oxygen. Inspired by The Emperor of All Maladies by Siddhartha Mukherjee, Travis has done a excellent job of telling the rich story behind the metabolic theory of cancer. In this interview, Travis and I discuss some of the potential benefits and mechanisms of a ketogenic diet, hyperbaric oxygen, gluconeogenesis inhibitors and ketone supplements as possible cancer therapy. I would like to thank Dr. Tommy Wood for some of the questions asked in this interview, especially those about glioblastoma and women with the BRCA1 mutation and breast cancer. Here’s the outline of this interview with Travis Christofferson: 0:00:15    Book: Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure 0:00:34    How Travis became in terested in biology. 0:00:54    Travis has a fundamental curiosity. 0:01:10    The best doctors are the ones that do experiments on themselves. 0:01:22    Book: Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer by Tom Siegfried. 0:01:38    Book: The Emperor of All Maladies: A Biography of Cancer by Siddhartha Mukherjee. 0:02:16    Travis wanted to tell the rich story behind the science in Tom's book. 0:03:01    Podcast: Dominic D'Agostino on the Tim Ferriss show. 0:03:30    The Emperor is gene centric. 0:03:46    The difference between the genetic and metabolic theories of cancer. 0:04:08    Radiation, cell repair. 0:04:09    In the genetic theory, cancer arises through lesions on DNA. 0:04:43    The genetic theory is still the dominant theory. 0:04:55    In the metabolic theory, cancer is proliferated by damage to the mitochondria. 0:05:07    Cancer resorts to less efficient fermentation. 0:05:25    This less efficient metabolism sends a message to the DNA. 0:05:42    This new theory makes cancer look like a disease of order. 0:06:02    Everything that causes cancer damages mitochondria. 0:06:39    Paul Davies, cosmologist. 0:07:07    Worked with Stephen Hawking. 0:07:33    Video: Anna Barker at TEDMED 2010. 0:07:53    Cancer is incredibly complex compared to other diseases. 0:08:19    In 2008 atavistic model 0:08:48    Three million studies on cancer on PubMed. 0:09:20    In the beginning, there was single celled organisms. 0:09:26    With multicellular life, the rules changed. 0:09:43    The foetal genes are reexpressed in cancer. 0:10:03    This new understanding gives hope. 0:10:17    What can we do with this new knowledge. 0:10:28    Look after our mitochondria. 0:10:38    A ketogenic diet is a great way to achieve this. 0:10:48    Also intermittent fasting. 0:10:57    Metformin as an oncology drug. 0:11:20    Exploiting the express of early genes. 0:11:44    The Warburg Effect. 0:11:53    Hyperbaric oxygen. 0:12:01    Cancer cells decouple of the adaptive immune system. 0:12:07    Cancer patients with high fever then spontaneous remission. 0:12:25    Cancer cannot withstand infection. 0:12:56    How does the ketogenic diet work against cancer? 0:13:04    Lowering blood glucose. 0:13:11    Glucose is the preferred fuel of cancer. 0:13:25    Some cancers can utilise ketones. 0:13:45    But there's promise in all cancers. 0:14:05    There's some kind of signalling mechanism. 0:14:27    Less side-effects with chemo after fasting. 0:15:05    Dr. Tommy Wood pointed me at some studies showing that certain breast cancers can use ketones as fuel. One study of women with the BRCA1 mutation showed that those with upregulated ketone metabolism did worse, which suggests that a cancer can develop metabolic flexibility too, and would be able to avoid death on a ketogenic diet. 0:15:27    Everybody is different and your results therefore will vary. 0:15:51    The brain can obtain up to 80% of its energy requirenents from ketones. 0:16:09    Some neurons are too small to include a mitochondria. 0:16:21    There is a trial going on in Arizona with glioblastoma. 0:16:25    Dr. Adrienne C. Scheck. 0:16:29    Results by April. 0:16:41    Kid in Norway, prognosis is 8 months, that was 3 years ago. 0:17:12    Tumor has shrunk and remained stable now for 3 years. 0:17:31    Metabolic therapies are good at managing cancer, but may not be the cure. 0:17:55    The studies are all done from the same line of glioblastoma. 0:18:17    Glioblastoma is where the research started, but the principle is sound 0:18:41    Will glioblastoma be the first cancer that we see a cure for? 0:18:48    Glioblastoma is usually about a year from the time of diagnosis to death. 0:19:17    How do cancers show up in a PET scanner? 0:19:24    PET scanners detect radiolabeled glucose. 0:19:43    The tumour outcompetes normal cells for glucose and show they show up in the scanner. 0:20:25    If the tumours have been lighting up in scanners for a long time, why has it taken so long for anyone to think of this? 0:20:41    Dr. Scheck’s study is using a standard ketogenic diet. 0:20:43    In some people that doesn't drive down glucose very far. 0:21:06    You can drive blood glucose very low. 0:21:21    In extended fasts, blood glucose would go down in the 60s (mg/dL). 0:21:24    Now we have exogenous ketone supplementation. 0:21:27    And gluconeogenesis inhibitors. 0:22:50    What were gluconeogenesis inhibitors originally designed for? 0:23:05    We're only just starting to appreciate Metformin. 0:23:06    25-30% reduction in the chances of getting cancer on Metformin. 0:23:07    Nobody really knows how is works. 0:23:31    Phenylbutyrate. 0:23:55    Metformin also inhibits complex 1 of the ETC. 0:24:07    ROS are bad, but also signalling molecules. 0:24:23    Another line of research has shown that Metformin works through altering the gut microbiome. 0:24:44    Podcast: Exercise is an antioxidant. 0:25:02    Podcast: Tommy and me on the Robb Wolf podcast. 0:25:11    Podcast: Insulin resistance. 0:25:15    Podcast: Iron overload. 0:25:46    In biology, you focus on one thing. One protein, one pathway. 0:25:55    Dr. Coe? in Travis's book. 0:25:56    ATPase. 0:26:15    You need someone to do the detailed work, but then you need someone to step back. 0:26:30    Physics already has a mechanism in place to do that. 0:27:05    In physics, you can come up with an idea and there's more than enough data to test it out. 0:27:31    Worse, in nutrition the data conflicts each other. 0:27:33    The NCI said that 80% of the basic research in cancer biology were not reproducible. 0:27:56    Sorting through the studies is an art form. 0:28:08    Warren Buffett. 0:28:22    What do you think of the meta-analysis? 0:28:53    This is the Gold Standard of science! 0:29:11    Book: Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health by Gary Taubes 0:30:36    Ketone supplements are not currently be used in cancer therapy. 0:31:09    Dominic D'Agostino specialises in ketone supplementation. 0:31:34    Ketones are far more than a macronutrient. 0:31:49    Ketones are anti-inflammatory. 0:32:08    Seasonal ketosis. 0:32:22    Dr. Veech at the NIH: "it's not normal to have a McDonald’s on every street corner". 0:32:30    It's normal to starve periodically. 0:32:53    Alzheimer's is now being called type 3 diabetes. 0:33:41    Is it a good idea to be constantly in ketosis? 0:33:58    Dr. Peter Attia. 0:34:32    Two studies, one at the National Institute of Aging, one at the University of Wisconson 0:34:37    Caloric restriction in monkeys. 0:34:49    Caloric restriction doesn't help as much as we thought. 0:35:02    The monkeys fed a high-sugar diet did worse. 0:35:27    When is all this going to be more widely know, or even the standard of care? 0:35:40    Things move slowly, it's easy to get depressed. 0:35:57    The trial in Arizona could be groundbreaking. 0:36:34    3-Bromopyruvate (3BP) could be the final piece for the metabolic therapy. 0:37:05    Heroin as the treatment for cocaine addiction. 0:37:47    Radical mastectomy. 0:38:25    This went on for 80 years. 0:38:37    In the end, we discovered that a local lumpectomy was as effective. 0:38:58    The trials are so slow and expensive. 0:39:16    You have to eat something, why not this?. 0:39:42    Travis talked at Paleo f(x). 0:39:57    Anecdotally, word is getting out there. 0:40:24    The ketogenic diet to treat recurrence. 0:40:37    The ketogenic diet is empowering. 0:41:11    Travis wrote an article about recurrence on his website. 0:41:20    It's not about always about a single cell that got left behind. 0:41:36    20% of cases are new, i.e. the environment for cancer is still there. 0:42:09    The same is true of bacteria, if you create the environment, it will grow. 0:42:25    Nobody wants to take high-fat diets seriously for weight loss until we're talking about cancer. 0:42:48    Cachexia is the the worst case scenario. 0:43:40    Valter Longo, PhD. 0:44:21    The state of ketosis doesn't say anything about weight loss, and may even be protective against muscle wasting. 0:44:42    Travis and Dominic's articles on Robb Wolf's website. 0:45:41    The Charlie Foundation. 0:46:04    Travis's new blog with podcast, Metabolic Optimization. 0:46:43    Dominic holds the Guinness World record for the most weight squatted in 24 hours (he broke the record in six). 0:47:15    Travis is a fulltime author.

Immunotherapy has been a popular topic ranging from its involvement in this year’s Emperor of All Maladies to recent groundbreaking presentations at ASCO. Dr. Glen Weiss, Director of Clinical Research at Cancer Treatment Centers of America at Western Regional Medical Center, will explain how immunotherapy can help a silenced immune system and how it can be part of an effective cancer treatment regimen.

Weekly JourneywithJesus.net postings, read by Debie Thomas. Essay by Debie Thomas: *Just Wondering* for Sunday, 26 April 2015; book review by Dan Clendenin: *Soul Whispers* by Edwina Gateley (2015); film review by Dan Clendenin: *Cancer: The Emperor of All Maladies* (2015); poem selected by Dan Clendenin: *I Wandered Lonely As a Cloud* by William Wordsworth.