Podcasts about silicon valley comic con

We don't forget our roots here on the show, as every year, Nerd Rage goes back to where it all started -- Silicon Valley Comic-Con, otherwise known as SiliCon. Tittymari Jothi takes the hosting reins while Marc is moving out of the dorms of Handsome Boy Modeling School, and does a fantastic job in front of a group of even more fantastic people! Mask up in public, cosplay or not, and always be ready to RAGE!Hosted By: Tittymari JothiSpecial Guests: Natasha Vinik, Ruben Escobedo, Stephen Ku, Kristee Ono, Cynthia In Public, and Ato WalkerProduced by Komedio ComedyFind more episodes of Nerd Rage! The Great Debates at NerdRagePodcast.comTo stay informed on Komedio live shows and podcasts visit http://Komed.io✉️ e-Mail us at KomedioComedy@gmail.com (put “Nerd Rage” in the subject line)Find us on Twitter at https://twitter.com/nerdragetgd or follow us on Facebook at https://www.facebook.com/nerdrageTGD for more updates.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

About AmyWith over ten years industry experience, Amy Arambulo Negrette has built web applications for a variety of industries including Yahoo! Fantasy Sports and NASA Ames Research Center. One of her projects modernized two legacy systems impacting the entire research center and won her a Certificate of Excellence from the Ames Contractor Council. More recently, she built APIs for enterprise clients for a cloud consulting firms and led a team of Cloud Software Engineers. Amy has survived acquisitions, layoffs, and balancing life with two small children. Links: The Duckbill Group: http://duckbillgroup.com/ @nerdypaws: https://twitter.com/nerdypaws TranscriptAnnouncer: Hello, and welcome to Screaming in the Cloud with your host, Chief Cloud Economist at The Duckbill Group, Corey Quinn. This weekly show features conversations with people doing interesting work in the world of cloud, thoughtful commentary on the state of the technical world, and ridiculous titles for which Corey refuses to apologize. This is Screaming in the Cloud.Corey: Your company might be stuck in the middle of a DevOps revolution without even realizing it. Lucky you! Does your company culture discourage risk? Are you willing to admit it? Does your team have clear responsibilities? Depends on who you ask. Are you struggling to get buy in on DevOps practices? Well, download the 2021 State of DevOps report brought to you annually by Puppet since 2011 to explore the trends and blockers keeping evolution firms stuck in the middle of their DevOps evolution. Because they fail to evolve or die like dinosaurs. The significance of organizational buy in, and oh it is significant indeed, and why team identities and interaction models matter. Not to mention weither the use of automation and the cloud translate to DevOps success. All that and more awaits you. Visit: www.puppet.com to download your copy of the report now!Corey: And now for something completely different!Corey: Welcome to Screaming in the Cloud. I'm Corey Quinn. I'm joined this week by my colleague, Amy Arumbulo Negrette, who's a cloud economist here at The Duckbill Group. Amy, thank you for taking the time to, basically, deal with my slings and arrows instead of the ones that clients throw your way.Amy: It's perfectly fine. It's not as if we are… not the kindest people within the Slack channels anyway. So, I am totally good. [laugh].Corey: [laugh]. So, you've been at The Duckbill Group, as of the time of this recording, which when you're releasing things in the future, it's always a question of how long will you have been here by then? No. We're playing it straight here from a perspective of, as of the time of this recording, you've been here six months, all of which, of course, have been during the global pandemic. So first, what's that been like?Amy: It has been very loud. And that's to say, I live in a house with five other people in it, so it's one thing for me to be a remote worker and just being at my desk, working quietly, but also having to manage noise that you can't really control, it's been an extra level of stress that I could possibly do without. It's fine. [laugh].Corey: One of the whole problems with the pandemic, from our perspective, has been that we've run this place as a full remote operation since it was started, and people come at this from a perspective of, “Well, this whole experience we've had with working remote is awful. It's terrible. No one likes it. I'm not productive.” Let's be very clear here. There's been a global pandemic; this is not like most years, and there are stressors and things that absolutely suck about this that don't normally impact the remote work story quite the way that they have.Amy: I totally agree. At least before, in one of my previous companies had an office in Chicago, so I would be there once a week, but effectively I was remote because that was an all meetings type of day. And the difference between that and now is that you had very explicit work hours; you had client hours; your work sometimes brought you out the house, if you had to go on travel, or on-site. This is just everything is done within the same ten feet of basically where you work, and you eat, and you sleep, if you have really unhealthy living habits like I do. And while I'm trying to get better at it, I'm also not the best at having time-based boundaries. I'm only good with physical boundaries. So, I have to turn off the work computer, to turn on the fun computer, which are physically next to each other, but I have to look in a different direction. And that is as close as I get.Corey: Yeah. It's the good screen versus the bad screen model of, “Oh, yeah, we're going to stop doing work now and just move our gaze slightly to one side and look at the fun screen and work on those things instead.” And at first, I was trying to be militant when we started the whole pandemic thing and working full remote of booting people of, “Hey, all right, it's quitting time. Go home and stop it.” The other side of that, though, is some people are, in some ways, using work to escape.So, we've modified our approach to get the work done. If you're working consistently more than 40 hours to get it done, let us know; that's a problem. But let people work when they want to work, how they want to work and be empathetic humans. And that carries surprisingly far. Now, the question, of course, becomes, does this scale to a company that has 50,000 employees? I don't know. That's never been a problem that anyone has asked me to solve. But it works for us at small scale.Amy: I find that the attitude working here has been really understanding as to, we know what our lives are like and we know what kind of work that we actually have to get done within a certain time period. And all of us make those. We don't feel the need to explain how we were able to get that work done or what time slots happen. You'll see me and Jesse—one of the other cloud economists—it's like we'll be hitting document at the same time at—for my time would be closer to later in the evening, but that's just because I spent most of the day either taking care of kids or handling house management sort of duties. So, having that flexibility on where my schedule goes without having to answer that question of, “Well, why were you working at that hour?” I feel gives me a lot more control and takes one less thing away that I have to worry about.Corey: One approach that we've always taken here has been that we treat people functionally like adults. And that's sort of an insulting way to frame it. Like, “What are you saying. That a lot of employers treat their staff like kids?” Well, basically, yes, is the short answer, where it's, “great, we're going to trust you with root in production, or a bunch of confidential customer data, but we're also not going to trust you to make a $50 purchase on the company credit card without a bunch of scrutiny because we don't trust that you're not embezzling.”The cross-incentives of different organizational structures are so twisted at that point that it's very hard to self-correct. I mean, our approach going into this was always never to go down that dark path, and so far, so good. Will it bite us someday if we continue to grow to that 50,000 person company? Undoubtedly. But I have to believe it can be done.Amy: I would also think the pressure of managing 50,000 people would break every single person in this company. Just thinking about it gives me panic.Corey: Oh, yeah. When every person becomes effectively, what, 500 people, that's divisional stuff. I don't think that anyone wants to stick around and see a small company go through those kinds of transformations because functionally, it becomes such a radically different place. For better or worse, that's not something we have to worry about, at least not anytime soon.Amy: We work really well with our fairly tight teams, I think. And it's I think it's one of the virtues of the type of work that we do. You don't need a team of 15 people looking at one document.Corey: No. And invariably, it seems like that tends to slow things down. Let's talk a little bit about something that makes you a bit of an outlier insofar as when you are only dealing with a small number of people everyone's inherently an outlier. You're the only cloud economist at The Duckbill Group with a background as a software engineer.Amy: Yeah. I did not realize that when I was joining. So, this deal with my infrastructure background is that I've only ever done enough infrastructure to support my applications. Like, Pete, I come from a startup background initially in my career, where you had to manage your application, you had to manage your own routes, you had to manage your own database connections, your own storage connections, and all of that, which, looking back on it and saying it out loud, sounds like a really bad idea now, but this was life before infrastructure as code and it was the quote-unquote, “Wild West” of San Francisco startups, where you can make a product out of basically anything. And the anything I went into was fantasy football of all things.So, I always made sure to have enough knowledge so that if I knew something broke, that I could blame it on networking, and then I would be able to show the paper trail to prove it. That was the extent of my knowledge. And then I started getting into the serverless space, where I started building things out of cloud services, instead of just spinning up more EC2 because I was young and impressionable. And that gave me a lot more understanding of what infrastructure engineering was like. But beyond that, I build APIs, I do business logic; that's really where my comfort levels are.Corey: For the rest of us, we seem to come from a background of grumpy Unix sysadmin types where we were running infrastructures, but as far as the code that was tied into it, eh, that was always the stuff we would kind of hand-wave over or we'd go diving into it as little as possible. And that does shape how you go through your career. For example, most companies are not going to wind up needing someone in that role until they've raised at least a Series B round, whereas in many cases, “Oh, you're an engineer. Great, why don't you start the company yourself?” From a software engineering perspective. It's a different philosophy in many respects, and one that I think is a little bit on the strange side if that makes sense.Amy: It is. It's extremely strange how completely dependent the two are on each other, yet the mindset to get into either and of that level of engineering is completely different. My husband and my father are both on the infrastructure side, and they've tried to explain networking to me my entire life, and I just—the minute the word subnet comes up, my brain is gone. It's like I'm replaying Star Trek episodes in my head because I can no longer handle this [laugh] conversation.Corey: That's how a lot of us feel about various code constructs at some point. For better or worse, we've made our peace with it, and let's be very direct here for a minute, we've learned to talk our way around customer questions that go too deep into the software engineering space, by and large. What's it like on the other side of that, where there's an expectation that you have a lot more in-depth infrastructure experience than perhaps you do? Or isn't there at that expectation?Amy: There is, I think a lot of that is just because of the type of industry this is. Cloud consulting is always infrastructure first because that is what the cloud is selling; they are selling managed infrastructures. They are giving you data center alternatives, but they're not giving you are full-blown apps. And whenever they do—let's say Lightsail—it's an expensive thing that you, somewhere in your mind go, “I could build that cheaper. Why am I paying for this service?”So, when I am on the phone with clients and they have a situation that is obviously going to be a software solution, where their infrastructure is growing, but it's because their software has a specific requirement, either for logging, or for surge, that they're using either Elasticsearch, or Kubernetes, or CloudWatch Metrics for, and it's turning into an expensive solution, it gives me an inside, “Well, this is the kind of engineering effort that's going to need to happen in order for you to write all of these problems and to reduce these costs. And these aren't as simple as hitting an option within AWS console to bring all of that down.” It's always going to be seen as more of an effort, but you also get a bit of empathy from the engineers you're talking to because you now are explaining to them that you understand what they built. You understand why they built it a specific way, and you're just trying to give them a path out.Corey: You mentioned the now antiquated idea of going on-site and talking to clients. I mean, before pandemic, Mike and I would head out to a lot of our clients for the final wrap-up meeting, or even in some cases kickoffs, because it made sense for us to do it and get everyone in the same room and on the same page. And over the past year, we've found ways to solve for these problems in ways that I don't necessarily know are going to go away once the pandemic is over. Is it more effective for us to travel somewhere and sit down in the same room with people, who in many cases have to travel in for wherever they live themselves? I don't know. There is going to be a higher bandwidth story there, of course, and the communication is going to be marginally more effective, but is it going to be so effective that it's worth more or less throwing a wrench into everyone's schedule for that meeting? That leaves me somewhat unconvinced.Amy: One of the strange things is that previously, I would go on-site to clients and fly out to where they are because as many startups as there are within Chicago, and the [unintelligible 00:13:10], and within Illinois, I'm always being sent to New York, or Atlanta, or Denver, for some reason because they're far and there're planes there. But we always end up having to talk to some amount of people that don't even work in that time zone, or maybe even then in this country, so we're talking to resources in Asia, resources in Europe, which meant we were flying people in to be on somebody else's phone. And I'm glad to not do that. I'm glad to not have to hang out in an airport, there is a burrito place in O'Hare that I truly enjoy, but that is the one thing I miss about traveling. I almost have my punch card done and it stopped right before then, but I'm kind of okay with that.Corey: I was chasing the brass ring of airline status and all the rest for a long time. I can't wait to finally go and hit the next tier and the rest, and where, well, the pandemic through all of that into a jumble and I take a step back and look at it and, you know, I don't miss it as much. What I do miss is that the opportunity, in my case, to get away from everyone that I spend all of my time with now, just for a day or two, and clear my head and recenter myself. But there are probably ways to do that that doesn't keep me on the road for 140,000 miles a year.Amy: I think, or at least I hope, that this will give us a chance to as an industry just reevaluate how we treat travel. A lot of clients treated it as essentially a status level that came with your engagement where we need you on-site so we can show off we have consultants coming in on-site so frequently to give us personal reports, even though we are all in a room on a conference call with other people. So hopefully, even if they're not forcing that every other week—sometimes weekly, depending on what your engagement is—type of cadence on travel, then maybe it'll just increase the quality of life for some of us. It would be nice. It would be super nice. I honestly don't see them forcing that anytime soon, but once everyone gets vaccinated, and there's a successful pediatric vaccine that comes out, it's like, I don't see them, just letting us stay at home and continue doing our job the way we have been for the past year, going on two years.Corey: So, dialing back into the mists of the distant past, it's always a question of where do cloud economists—or clouds economist, depending upon how we choose to mis-pluralize things—come from. And everyone here is a different story and there's not a whole lot of common points between those stories. You, for example, spent some time doing work with NASA. What was that about?Amy: There's a lot of misconceptions about working for NASA like you need to be a doctor. [laugh]. And trust me, you don't. I knew a lot of people who work there that they basically got their degree, and then they just did code work forever and they are lifers there. And it's such an interesting place to be because, on one hand, you have that mission of space and exploration and trying to do better by the world, but also, it's still a federal agency and there's still a lot of problems with federal agencies in that how you get paid is essentially at the beginning of the year, that's when all the budgets are done.So, you can't do the startup thing where you go, I'm going to try a bunch of things, and if one doesn't work, I'm going to pivot to something else because you're essentially answering taxpayers and they don't let you do that. No one wants their taxes going to someone who tried a thing and then found out they messed up. Which is unfortunate, but also a really hard reality of the way these work.Corey: I really love installing, upgrading, and fixing security agents in my cloud estate! Why do I say that? Because I sell things, because I sell things for a company that deploys an agent, there's no other reason. Because let's face it. Agents can be a real headache. Well, now Orca Security gives you a single tool that detects basically every risk in your cloud environment -- and that's as easy to install and maintain as a smartphone app. It is agentless, or my intro would've gotten me into trouble here, but  it can still see deep into your AWS workloads, while guaranteeing 100% coverage. With Orca Security, there are no overlooked assets, no DevOps headaches, and believe me you will hear from those people if you cause them headaches. and no performance hits on live environments. Connect your first cloud account in minutes and see for yourself at orca.security. Thats “Orca” as in whale, “dot” security as in that things you company claims to care about but doesn't until right after it really should have. Corey: I must confess that I'm somewhat disappointed that you opened with, “You don't really need to be a rocket scientist to work at NASA,” just because, honestly, I was liking the mystique of, “Oh, yeah. You need to be a rocket scientist to understand AWS billing constructs.” But I suppose if I'm being honest, that might be a slight overreach.Amy: I knew a lot of people there who had multiple PhDs, and they could barely keep their computer on, so really, I'm finding that I respect very smart people, but it also does not imply your world intelligence anywhere else outside of that very specific field. One of the really weird things about having worked there—I worked at NASA Ames as part of their IT department—one of the things we did as outreach was, we did a booth over at SiliCon Valley Comic Con once, and it was great. We had a vintage display of old electronics, like CRT monitors, and full keyboards, and all of this nonsense, and kids would go, “These are so old. Why would anyone use this? It's so boring.” [laugh].And the entire IT department showed up to volunteer. We're like, “No, you don't understand why it's interesting. It's great.” It was so, so hard to watch young people just [laugh] not be interested in what the past of digital devices were. Very sad. And on the other hand, we did get a lot of interest, but it was also having to have that conversation in real life can be a little disheartening.Corey: It really is.Amy: But it was fun because it was one of the few things that you don't really get to see NASA at a comic book convention, so that was actually a really cool thing to do. Also, we got free tickets, so that was great.Corey: So, what was your background before you got to the point of, “You know what I want to do? Work for a consultancy, whose entire mascot is a platypus, and from there, go ahead and fix AWS bills,” which sounds like, to folks who aren't steeped in it, the worst thing ever? What series of, I guess, decisions led you here?Amy: I know you don't remember this, but we actually met at Serverlessconf, and you opened your talk with, “I am a cloud economist, a title I completely made up.” Your talk was right before mine, so that's why you didn't remember I was there because I was actually on the backstage getting prepared for my talk.Corey: That's right. I would have been breathing into a paper bag right before or right after my talk, trying not to pass out. People say, “Oh, you won't be nervous once you give enough talks.” I'm still waiting.Amy: It never happens. I did finally stop having blackouts, so that's an improvement. It gets better, but it never goes away. And when you told me that, and I saw the listing, I'm like, “I don't know what this job is. There's an easy way to find out what the job is, and that's to apply.”And that is when I started going through the process of applying, and then you hired me some months afterwards. And the thing that I found out about looking through AWS billing is that I found out I have a very specific skill set, in trying to find a discount while looking through receipts. This is a thing I thought only applied to my personal life because I don't really like paying retail prices for anything, so I'm always looking for a way to squeeze out another 20, 30% out of something because 10% is really just taking taxes off of stuff. And the fact that I was able to apply that very specific skill set to an actual technical job is so much fun for me because I like being able to tell stories out of what people spend, just because it is—as we say around here—it's the sum of all of your engineering decisions. Because everything you do, there's a price tag on it. And knowing how you got there, and that you can optimize the architecture by looking through the bill is super fascinating to me.Corey: So, now that it's been six months, is the job what you expected it to be? Is it something radically different? Is it something else?Amy: The tone of our engagements have actually changed within the past six months, partially because of the way AWS has made some organizational changes internally as far as we can tell. But really, it's also what types of companies are finding out that they need a service like this. Before, when I was interviewing, and when I started, I was talking to Pete and Jesse about the types of engagements you do. It was for larger companies; they're looking for some amount of savings, and then we run some tooling and then we get back to them. And now it's turning into… some are relatively small companies, companies that wouldn't get use out of an EDP, for example, because they're spending so low.But also other companies, they don't even really want this saving specifically, they want validation on what the process is like, they want validation on their unit economics and what the cost allocation strategies are. So, it's fascinating what people actually want now that they understand that that option is out there.Corey: One thing that you mentioned a minute ago, was the idea of going and giving talks—in the before times, at Serverlessconf and things like that—how do you find that that has changed for you over the past year? And how are you viewing a slow, but effectively guaranteed in the long enough timeframe, return to normalcy?Amy: So, when everything went virtual, it was a really hard transition for a lot of communities. I'm part of AWS Chicago, I'm an organizer at a meetup group called Write/Speak/Code where our whole deal was to give women and people of underrepresented genders the opportunity to learn how to do open-source, how do you learn how to do technical speaking, we helped them with their CFPs, and all of that required a physical community in order for us to be able to give each other that type of support. Well, we can't do that anymore. The last big event we did was specifically around getting everyone set up into the organization. So, we do one big one every year where we tell you how to do slides, we tell you how to do everything, and then the rest of the year smaller meetups where we do feedback and prompts and other types of support events.Now, that we can't do that, we found that a lot of the people who ran these events, they're extroverts and they're social to begin with, so they got burnt out very quickly, which meant we not only had to find new ways of supporting them but also reaching out to members and making sure everyone could still do the types of thing we promised we'd help them to do. The other issue is that with things going virtual, there used to be clear lines on the types of events you could apply to, which were events that I could reach, that my company would pay for, what have you. But now everything's virtual, I accidentally applied to a meetup that I spoke at that was based in Australia, which meant I was talking at 10 o'clock at night, just because I explained to them the mix-up and essentially begged to get an earlier slot. And it's interesting because it presents both a wide array of opportunities, but it also means that there's now so much noise, and so much burnout and fatigue from these one direction types of conferences, which are long Zoom meetings, which is basically everyone's workday now, which is just full day's worth of Zoom meetings. And it's hard to get people interested.And really, what these events did best was give people who generally don't have that type of visibility—like me—who, I am a female engineer, and I am a person of color, so my opportunities aren't always going to be as well as they could be, but this visibility also gave me a boost. So, when we lost out on physical events, my organization personally lost out on a lot of things that we could do for those people, which is unfortunate, but it's also what was happening, really, everywhere. Now, we're gearing more towards how to do less Zoom meeting type of events, and we're now using a tool called gather.town, which lets everyone go into a space, you can walk around, you can drop in and out of conversations like you would in a hallway, and it has this cute little eight-bit kind of avatar feel to it so it looks kind of like a game, but it's also—if you go around a large group of people, it pulls up everyone's picture and then you're suddenly speaking to each other over voice without having to physically join in or wait for a breakout room or wait to be let into a different room. So, it's been difficult to try to find ways of managing it, but it's also been very interesting seeing the tools that had come out of this.Now, once we start going back to physical events and on-site events, personally, I have a lot of anxiety about that just because my allergies and everything makes it hard for me to do travel in the first place, but also, I'm not really sure how everyone's going to react being in the same space anymore, or how full they're going to be. So, to me, it does cause me a little bit of anxiety and I'm going to wait a little until things are more settled and are a little more stable than they are right now. That said, I believe AWS Midwest is doing something physical at the end of this year. But I'm not entirely positive about that.Corey: One of the things I want to avoid is going back to an old style of re:Invent, where it's only open to folks who are able to spend $2,000 on a ticket, travel to Las Vegas, and get the time off and afford the hotel stay and the rest. One thing I loved about the 2020 version of that was that everyone was coming from a baseline of its full remote. There was no VIP ticket option that got you a better experience than anyone else had. And I do worry, on some level, that as soon as they can, they're going to go running back to a story like that. I hope not.Amy: I hope not, too, because one of the great things about virtual re:Invent was everyone saw the same things at the same time. And you didn't have to give up one panel because you're too busy being in line for another panel. And I've never liked that type of convention activity where you know you're actively giving something up just because the line for the thing you want to get to is so super long. That said, they could have done better a bit on the website. The website was really hard to navigate and confusing and the schedule was weird.If they get that kind of usability fixed and a little more reasonable so that things are surprisingly searchable and easier to navigate, and they have more social type of events instead of AWS is going to—it's going to announce another service that they're calling a product, even though it's just… it's a service enhancement, and that's all it is. I would like for all of that to kind of be streamlined so it's not just more announcements. I can read announcements. I don't need to watch two hours' worth of announcements.Corey: I really hope that at some point, some of the AWS service teams learn that, “Hey. We could announce services anytime of the year,” rather than in a three-week sprint that leaves no one able to pay attention because there's just too much.Amy: And it's hard because it's hard when you have to hold a release because re:Invent's coming up. Or you have to be part of their Developer Relations Group where you have to do all of your training and all of your docs right beforehand, just so that it's prepared for this launch that people may not hear about because it gets drowned out in all the other noise.Corey: And that's sometimes part of the entire problem.Amy: Yeah.Corey: Thank you so much for taking the time to speak with me. As always, it's a pleasure. If people want to learn more about what you're up to, where can they find you?Amy: They can hire me for engagement here. [laugh] but also—Corey: Good answer.Amy: —I do technical talks. I don't have anything lined up right now, just because it's spring in my brain took a break, like everyone else did. I'm on Twitter as @nerdypaws because that was a handle I had since college and have not changed.Corey: Excellent. And we will, of course, leave a link to that in the [show notes 00:31:10], as we always do. Thank you so much for taking the time to speak with me. It's always a pleasure, and it's deeply appreciated.Amy: It's always a good time talking to you, Corey.Corey: Amy Arumbulo Negrette, cloud economist here at The Duckbill Group. I am Cloud Economist Corey Quinn, and this is Screaming in the Cloud. If you've enjoyed this podcast, please leave a five-star review on your podcast platform of choice, whereas if you've hated this podcast, please leave a five-star review on your podcast platform of choice, along with a comment telling me why you do in fact need to be a rocket surgeon in order to properly work on AWS bills.Corey: If your AWS bill keeps rising and your blood pressure is doing the same, then you need The Duckbill Group. We help companies fix their AWS bill by making it smaller and less horrifying. The Duckbill Group works for you, not AWS. We tailor recommendations to your business and we get to the point. Visit duckbillgroup.com to get started.This has been a HumblePod production. Stay humble.

The Two Marks with Attitude, Bimbo Jimbo and Baby Huey are back with the latest episode of In the Kliq! This week: The guys recapped Stone Cold Steve Austin's panel at Silicon Valley Comic Con, NXT is moving to USA Network in a move that many feel is to counter All Elite Wrestling, Jon Moxley is forced to withdraw from All Out, the King Of The Ring Tournament has begun and more! --- Support this podcast: https://anchor.fm/inthekliq/support

In this episode, Bob & Kevin talk all things CRISPR - basically the REGEX of DNA editing... and guess what? Apparently you can do it at home... soak in the transcript below (from our friends at https://otter.ai/) and feel free to ping us on social media with your thoughts on this episode or any of our others - Follow us on twitter at https://twitter.com/bobandkevinshow.  Kevin 0:00 So Bob, is this a safe place for discourse? Bob 0:06 I hope so Kevin 0:07 good. Because Bob 0:09 I've been pretending it is for quite some Kevin 0:11 as we have the normal show disclaimer, but rather than disclaim, I mean, we'll do the normal disclaimer. But rather than just do the normal disclaimer, I'm going to go ahead and say it right now. I'm probably going to piss off the science folks. And I'm probably going to piss off the religious folks. Bob 0:27 Why are you going to piss off the science folks? That doesn't seem like something you would do? Kevin 0:31 2020 outrage culture was born. Not that long ago and people disliked we pissed. Bob 0:38 So what do scientists play that game? Because they're pretty factual. Kevin 0:42 There's there's different kinds of scientists, right? There's, there's Yes, there's just I mean, they're humans, right? So it depends. Bob 0:51 I guess I just don't see Neil deGrasse Tyson getting outraged. Kevin 0:54 So something number scientists so something happened in 1984 Bob, do you know what happened? Bob 1:02 George Orwell wrote a book. Kevin 1:05 Now he actually wrote that in 1948 but you know about the year 1984 I probably got the year you write it wrong, but as a long time ago anyway, know what you meant to say, but you didn't say is gozer that goes arion asks the Ghostbusters if they're gods. And Bob, do you remember what they say? Bob 1:26 Oh, how did I How did I misquote that? Right? Unknown Speaker 1:31 You? Kevin 1:33 So do you remember what the Ghostbusters replied? Who you gonna call? Oh, in fact, they said no. I said, you know when gozer says are you a god? And they're like, no. And then she like tries to destroy them. So how does this okay, I am I'm a bastion of useless pop culture references. Okay, so Bob, would you like to play God unearth, Bob 2:01 Kevin. I think I have since I have children, doesn't that qualify? Kevin 2:06 Yeah, maybe I guess he kind of brought life into this world and the common thing is I brought you in this world. take you out, take you out. At least that's what I was told when I was a child. Okay, so playing God, Bob 2:21 I don't really know if I have God like playing God like tendencies. Like I'm a floater. I just kind of go where the wind takes me for the most part. Kevin 2:29 All right, so Unknown Speaker 2:32 would you Kevin 2:33 consider saving or manipuri manipulating populations of species of animals on earth a bit of kind of messing with how things work kind of kind of godlike a little bit. Bob 2:51 I know where this is going. I know where you're taking me. Oh boy. Um all right no but we do well let's naturally or not Kevin 3:06 we let's develop it a little further. So there is like an article and I think his name was Diego or something the turtle maybe maybe you know his actual name. He He's been tasked he's a giant turtle has been tasked with making babies making more giant turtles. Bob 3:22 I think he succeeded and they set him free. Yeah, he made like 2000 Kevin 3:25 babies so there is at once you know a very small number. Now there's 2000 thanks to his sexual prowess as a giant turtle right? Did they I didn't read the article. Did they do it naturally or did they do it extraction and implantation? I'm pretty sure he did it the old fashioned way, Bob. Good. No, yeah. So if you listen to Joe Rogan, which I know we both do, sometimes I'll mention, wolves are being reintroduced to curb like elk populations, or do population and things like that. And other things that we kind of play God as humans is genetically modified organisms. And you and I have talked a little like three sentences, maybe on the pod and maybe a little more off about where we are with genetically modified organisms. And for the lay user, a GMO is basically vegetables that produce bigger fruit. It's going to be chickens. Well, actually, before we get the chickens, Bob 4:32 it's gonna be basically but since the dawn of, but hang on since the dawn of time we've been genetically modifying just by breeding. Kevin 4:41 Yeah, and like, just like the turtle the good old I was trying to come up with what what do we call that as humans because we took corn because like the original corn was like really nice. You know, small Meeker looking and we use I guess, expedited natural selection to make the corn super fat and feed population. Bob 5:01 Well, you brought up apparently something similar has happened to bananas as well, because apparently the bananas of old don't taste like the bananas today. Well, Kevin 5:09 how long have bananas tastes? They don't exist? Bob 5:12 What? I don't think the bananas of old actually exist anymore. Kevin 5:17 All right. I mean, there's those things called playing pains or whatever they kind of look like. But I Bob 5:22 think that there's I'll have to find the article and maybe put it in the show notes. But there's definitely some discussions about how bananas have been genetically re engineered, you know, but through breed, you know, Kevin 5:34 bananas are like the number one selling thing at Walmart. I believe. Yeah. And I used to work at a Walmart distribution center, grocery one. And bananas were like the first class citizen and products in the warehouse. I mean, you want to get in trouble. Go mess with the bananas. There's a whole team of people that will like take you down, if you can try to mess with the bananas. It's amazing. Bob 5:58 All right. So we've we've crossbred corn Well, it's just it's very popular in the plant world to cross pollinate species to create a new plant, whether it'd be more suited to feed more people or visual appearance plants, you know, like flowering plants are pretty common there. Kevin 6:20 So there's a lot of people who are against GMOs because I guess they ignore the idea of natural expedite and natural selection because that's air quotes nature. There's also the laboratory version where they're kind of doing gene editing and then you there's no shortage of labeling. If you go you'll see gluten free and then you also see non GMO on the on the box too. Bob 6:42 But do you think so, as far as that classification goes, they're talking about laboratory genetically modified, not classic, just cross pollinate, and I saw a tweet and I'm not gonna be able to give the person credit, Kevin 6:55 but basically, it came down to the difference between laborat And natural selection is basically this human emotional laden burden that you put upon yourself because at the end, they both won't kill you. They both taste good, and they both will feed you. So who cares whether it was in the lab or natural selection, right. Bob 7:16 But I think in this is probably getting to the crux of we're going to anyway, I think that the general fear is if we're doing this artificially, in even so far as the artificially not encouraging the crossbreeding of species, those kind of things. But if we're doing it in a scientific lab, underneath microscopes with, you know, syringes and centrifuges, and things like that, I think the inherent fear is that that's going to cause a domino effect of negative consequence. Right. Kevin 7:49 And if we stick with food for a moment, and I told you, you know, what, here's corn, I'm not going to tell you whether it was modified by the laboratory whether it was not modified at all or was we just had many, many, many generations of expedited natural selection. Here you go. Would you eat it or not? Or would you care? Bob 8:10 I probably wouldn't care. I definitely wouldn't know. Although like supernatural stuffs tends to be a little bit different flavor, profile, texture, all that kind of stuff. But I mean, yeah, the, it really makes no difference to that the Kevin 8:24 other buzzword in food is organic, which if you look at the rules, basically there's as long as you check back to two or three of these boxes, you can use the word organic, but it's totally in my opinion, non GMO and organic is totally a marketing term. It's totally just some hipster way of saying we're better than you and it's just the new marketing. What do you think? Yeah, Bob 8:46 organic is more of a organic is definitely more of a an encouragement to follow a specific set of standards is outlined by some organization where the GMO is almost like a confession or not confession, like you know, so we're just letting you know this product has been genetically modified and I probably should have looked up for that. So what the true definition of genetic genetically modified is while I news on this next topic, maybe if you want to ask Mr. Google or so the next part is and so we talked about plants, and you mentioned the word breeding. So we breed plants we also breed animals so we have dogs right we I own two labradoodles that's unnatural for the most part, unless you have a Labrador now poodle, who are like friends lab thinking uh, you know, tootles can keep asking rato day Yeah, they use Kevin 9:42 like doggy Tinder, it's really weird, but you know, to, to labradoodles. So bark, left bark. And then we also have so we don't eat dogs. Well, unfortunately. But we have cattle, pig, sheep, you know, that sort of thing. We do have like the Bacon's and the stakes of the world. And we've also done a an expedited natural selection of those. We also have things like this is antibiotic free, we have free range chickens, things like that. So we definitely, I don't know that that rises to the level of God, but it definitely rises to the level of manipulation. And hopefully I've got enough time for you to tell us what GMO is defined as, Bob 10:28 Oh, totally GMO, or genetically modified organism is a plant, animal micro or micro organism or other organism whose genetic makeup has been modified in a laboratory using genetic engineering or transgenic technology. Kevin 10:46 A couple couple $5 word. That's right. We'll just go with it. Some science involved, right? Bob 10:51 Well, I think the I think the important part is laboratory. Okay. So if there's two different crops in a field and they cross pollinate, and it makes a crop that more suitable for fill in the blank that is not genetically modified that is just good old fashioned farming. Unknown Speaker 11:08 You are listening to the Bob and Kevin show with Bob Baty bar and Kevin chesky. Each week we cover relevant tech and social issues related to technology. Our website is Bob and Kevin dot show. And our episodes can be found virtually on any Podcast Network. Be sure to follow us on Twitter, Instagram and Facebook. Just search for Bob and Kevin show. Kevin 11:46 Just to take it to the extreme because that's what we do here. So if I now build four walls and a roof around your field, and they're making babies under the roof, and I stick a sign on that says, Kevin's laboratory farm is that now GMO Bob 12:03 Would you be using genetic engineering or transgenic technology? I think the operative words in their engineering and technology Kevin 12:15 i don't know i don't think Bob 12:16 i don't think you would. I think if you put a house over your plants that we're doing it with people don't the plants that weren't there species I think Kevin 12:25 you're I was gonna ask you then if the tomatoes that are growing in a window at grandma's house is she, you know, practicing GMO so I guess we're saying no, Bob 12:34 so well, it's funny that you bring that up because I'm sure we'll touch on this later. Well, I'll save that. Okay, where are you taking this next? Kevin 12:43 Alright, so manipulating, breeding, growth of vegetables laboratory, things like that takes me to, you know, like, when when when an animal is going to be extinct like the turtle or loner like the black rhino or pick pick some sort of an Dangerous species as humans, and this is where I'm going to piss off probably, I don't know, maybe everybody I look at that and go, maybe we maybe we should let them all die. You know, please don't ask me. But I'm Bob 13:14 asking No, but I think there's a definite, I don't think it's just you. I think there's a whole camp of people who believe that the natural consequences of all of our actions are those natural consequences, and we should let those play out. I think there's obviously another group camp of people who believe that we should do everything within our power. I'm doing everything in air quotes, by the way, right, everything in our power to stop that destruction based on our natural consequences. But then, however, some people in that camp would be appalled if quote unquote, unnatural methods were used to course correct, even though unnatural methods probably put us on the course in the first place. Kevin 13:56 Right. So to recap, I on one hand, we introduced Wolves to bounce an ecosystem. On the other hand, we take an ecosystem that is favoring the extinction of obsolete potentially animals. And we we artificially prop them up as Bob 14:13 well. But I think in a lot of those cases, those are reintroductions. So, let's say especially as it relates to the wolf, the wolf used to roam free across many a continent. And then due to expansion, technology, and probably very specific measures to remove wolf populations from an area. Now, we're finding that they did serve a purpose in the conservation effort and management of wild animals. So now we're reintroducing species back into areas where they used to be but aren't any longer Kevin 14:57 and I get the whole idea that ecosystems can collapse and you have to possibly recognize it and make adjustments. But let's take it to the extreme of Bob and Kevin show favorite. So the Tyrannosaurus Rex was not completely extinct by a meteor. In fact, they lasted until the early 20th century. And the final ones were placing the captivity. Do we need to keep them alive? Is what I'm getting. Bob 15:25 Yeah, I'm sorry. Wait, wait, this is fake. Oh, Kevin 15:29 totally. Yeah. So okay. Bob 15:32 I was like, what books are you reading? Kevin 15:34 No, I am definitely at risk of sounding like weird flat earther. guy. I completely hypothetical. What if the T rex lived to modern times? Would there be people out there going we need to save the T Rex. Meanwhile, we haven't heard from that person in a while after the after they tried to feed it, you know? Bob 15:52 Oh, without a doubt. There would be the save the T rex people. All right. Kevin 15:58 All right. So now we've kind of set the table here. So, imagine me, Bob 16:03 I'm smoking. Kevin 16:04 Where is this going? So imagine you had the ability to bring back the T Rex, kind of like Jurassic Park. But your scientists were so preoccupied with whether or not they could they didn't stop to think of a shot. Or more likely, you had the ability to prevent or cure people of genetic diseases such as I don't know. I don't know, bad stuff. There's a whole list of bad things. Bob 16:30 Hold tight hold total list and imagine Kevin 16:33 that there's a technology allows you to cut and paste DNA like it. We're a frickin Word document, and just change the genetic code. And the recap. DNA is the double helix thing and it's got four sets of possible letters, I forget the four letters, it's like TCGA or something like that. And those are the only depending on how you combine these that's that's basically what defines Bob you as person me as person. And then everyone else. So sometimes there's errors in those. And those errors give rise to diseases. So there's a technology called CRISPR. Bob, do you know what CRISPR stands for? It's an acronym. Bob 17:15 I do have a tab open somewhere that tells me what CRISPR means. All right. Kevin 17:23 clustered regularly interspaced short palindromic repeats, wow, say that 10 times fast. So we're just going to call it CRISPR moving forward, Bob 17:34 and it's also typically grouped with a Unknown Speaker 17:39 protein called cast Kevin 17:41 nine, but there are more than one. So there's technology and it's I don't want to call old technology, but it's emerging technology, but it's been around for at least five years or so. And it allows this cut and paste of somebody's DNA. So the first question I had for myself was this Wait a second, you can cut and paste so DNA but DNA is per cell, right? So each cell has the same DNA, but if I want to cut and paste, you know, a skin cell, great, but what about the other cells in my body? How do I, you know, make it propagate through my body or whatnot. So I looked this up. And there's two ways to do this. They can either take cells out of your body, cut and paste and then put them back in. Or they can add at at the sperm egg level at the embryo stage, you know, right when it combined get the first cell they can edit that one cell, and they subdivide, now it's in every cell in your body sounds awesome, doesn't about we can just cure every disease, the end. Bob 18:44 Highly unlikely that that's the short. All right, well, Kevin 18:46 let's let's look some more at kind of how it works. So I watched the, I guess, the equivalent of TED talks and stuff on this in different videos on YouTube. So essentially, what CRISPR is is a molecular scalpel. It's actually according to them, Well, actually, it's very accurate, easy, quick and inexpensive. Those are usually things you don't associate with like new modern cutting edge tech technology, right? Bob 19:13 Yeah, I think like legit machine is only like Kevin 19:16 10 grand. And so there's a you can you can buy kits online for about $200 and you can do biohacking on yourself. And the way it works is in your cells, you have RNA, and they they program these proteins to look for a certain sequence of genes or nucleate proteins, if you will, in your body. And once it finds a match, it will then cut and paste the take the old one out, or I guess it'll be cut and recut. Yeah, it'd be cut and paste. Bob 19:50 Yeah, it can remove completely, it can replace or it can repair and repair would just be realigning the CGS T's and the is to put it in the desired sequence. Kevin 20:04 So the programmer amigos, ah, so this is pretty much a regex. So based on this pattern and kind Bob 20:11 of it kind of is Kevin 20:12 and Bob, when you if you have 99 problems totally. Okay. Yeah. So, because imagine what would happen and this happens all the time programming, hey, I think I got the the pattern to match and then you apply in it, either a doesn't match or B. What's worse is it matches a bunch of stuff you didn't intend it to match. So that's, that's kind of, Bob 20:36 if I have trouble with a regex for a phone number, for instance, right? You're telling me that scientists have figured out the regex for all DNA sequences or Well, I guess I haven't figured out for all of them. But they the literature says it's relatively simple. I believe that's a quote to pretty much decode anywhere they want to Kevin 20:59 so We can't so phone numbers, tough emails even more like controversial because there's like, hey, I need to read it. If you Google the regex for email, you will get so many answers that all of them say are right. And then there's the well, actually guy who always puts a little comments that go for it. Well, actually, it doesn't cover this cares. Okay, whatever. I got it. Okay. So, what's what's this best for? Well, apparently, if you have a single gene that's jacked up, this is the best thing so far that they've got. And one other delivery method that they have for this. And the idea here is this is going to cure some disease, that one delivery method that they're trying to use is create a virus that attacks every cell in your body, and it performs the cut and paste everywhere in your body. So the virus becomes Yeah, the transport mechanism, if you will. Bob 21:53 That's basically the process they were outlining in NPR. episode of radiolab that I listened to a couple years ago. I think they actually just revisited it not too long ago so Kevin 22:08 one of my kids has to get monthly infusions at the hospital and we have to do that for his foreseeable future for life as far as you know cuz he got a jacked up immune system. So there's a bit of an appeal here that hey, you know, we can do this here. If you know somebody with cancer, I guess that's one application to they can program. Things to, you know, attack cancer. But what, what is kind of weird when people kind of go to the Black Mirror episodes are you know, could you create a super soldier? Could you create a designer child or whatnot, right, so that's where it starts getting weird. Bob 22:46 Well, I think that's the slippery slope for most technology. Even that Netflix, limited series, I guess is what they're calling it that you had recommended even in episode one. That the practical uses versus the I would say cosmetic uses that Joe user biohacking in their basement. Like it was almost three to one cosmetic type. Kevin 23:14 Wow, that's an awesome transition because I got a list of things here that well, if this were possible, what what could people use this for? Well, obesity would be one of them, right? Hey, I want to be able to eat whatever I want. And I want my body to be able to just whatever, you know, that's, that's what I want Oreos every day and I still look amazing. So that's, that's one thing that people would use for vanity, right? Bob 23:39 Yes, so you got that metabolic and then also, like the muscle tissue, like the ability to multiply muscle tissue at a faster and Kevin 23:47 just to make things weird. Breast augmentation, right. Right now, it's very popular for women to do breast augmentation or reduction, if you will, some sort of body modification there and for men I don't have to lead you very far to tell you what men might want to do. Bob 24:05 If we say male enhancement, can we put that in the show title and get that click Yes. Kevin 24:10 Let's say one more time male, enhance male and there we go. So it'll definitely be in the transcript. Now, the SEC to me would be the next thing. Wouldn't it be great if you didn't have to do anything other than take an injection and now you're just Bob 24:25 shooting blanks. They almost have that down to an injection at this point. Anyway, it's such microsurgery so Kevin 24:32 and along these lines, what what if we perfect this so much, and I'm just going I like going to the black near end of the spectrum, sometimes what if we no longer procreate the old way air quotes, everyone becomes sterile through an injection, and then you just order your baby online Bob 24:51 you from the central repository. Kevin 24:53 You've heard this story before, except this time, you're going to take a swab of your mouth and then your potential mate And he sent both q tips in and Eddie that sounds high and for Box Tops from your favorite cereal and it goes to the central repository they engineer your child from an embryo they basically go the freezer and you know do their thing and you know drop in your whatever it is they do and then your kid shows up the woman doesn't even have to go through the pain of childbirth anymore they everything is custom ordered. It's your kid there's hopefully knows no swapping of DNA with the wrong donor you know? Yeah, whatever. What do you think? Bob 25:37 Let's let's take it back a half stuck, because I think the one of the original like sales jobs part of this would be we can eliminate x and x in this instance the sales job part of it would be something awful that is taking lives at a at a high rate at this time. current state in our you know our our global community of people so let's say that that works like without without a large dollar payment because it seems like this would be in the best interest of mankind so why would it be expensive first of all that would never go down like that it would be super expensive to start but let's say that they could fix something that that affected a lot of people the the immediate cascade effect is that of that is we have people starving all over the world now anyway, they do. So why would we want to artificially inflate our population that's already growing at an extreme rate? Kevin 26:40 And oh, so one of the specials that I was watching brought up immortality sounds great, right? We can live forever that's a shitty idea. It is a shitty idea and be even if you double the life of humans 200 years imagine the food requirements and the just the Annette air the the The actual cleaning of the human population numbers won't happen at the same rate. I mean, you want to talk about overpopulation now, Bob 27:08 right? The only thing I could think of that would be worse than being 100 would be being 200. Ah, Kevin 27:14 well, okay because of aging, but did you know that the common lobster does not age? Bob 27:22 Okay, by what standard? Kevin 27:25 I don't know I they were talking about how lobsters don't age and I guess squids, there's like different things that don't they still die. They're not immortal. But they don't age. They're the same, like, age wise. I don't know how you determine age of a lobster. But Bob 27:40 you asked him, Hey, Kevin 27:44 I'm 32 but I feel like I'm six months or whatever. Bob 27:49 I'm calling so much bullshit on that statement. The lobster doesn't Google it. Kevin 27:54 Check it, look into it, look into it. Bob 27:57 Alright, but the simplest Like ourselves age, like that's a known thing, cells age and die, right? And they're not they're not the same as the day that they were formed. So how do we have organisms swimming around our oceans don't age? Well, Kevin 28:13 I we'd have to look up the definition of aging. But the implication here is if humans can take lobster DNA and put it into humans, perhaps we don't age either or we can even reverse the effects of aging. Bob 28:26 Or we end up with a hard outer shell and well, okay, Kevin 28:31 see, I love I love your we didn't plan this. But you have another bullet point I have on here. Bob 28:37 Also, we never plan anything just in case. Well, we don't we do plan Kevin 28:42 separately, just not collaboratively. So right. But imagine, we're like, Hey, we got this figured out. You can go on Amazon. Order your crisper kit. You're like, Hey, you know what, instead of those tacky wild eyes for Halloween, I want real red eyes this year. So you go on Amazon you buy a crisper kit suddenly have red eyes You're like I'm getting tired of the red eyes. Let me go back to blue. Oh, you should make them like glow bioluminescent eyes when that be cool, you know kind of like the night King from Game of Thrones. Yeah, yeah. Add that to cart to Yeah, get one for me get one for me right what could go wrong? Bob 29:17 Yeah, but have you ever cut a piece of paper and then pasted it back together and then cut it again and pasted it back together. Eventually, eventually the ship gets shorter. And eventually it just breaks Kevin 29:28 kind of like if you take a JPEG and just keep receiving 1000 times it turns into this. So what I'm getting at here is, are we risking creating bio disasters by making this super easy and convenient? I would say yes, we're going to have that exoskeleton that we didn't mean to get from the lobster because we thought we're getting a no aging but now we have these freaks of nature, right? Bob 29:53 Yes. And did you see that panel is like the Silicon Valley Comic Con, which I imagine that's probably like the biggest freak shows of everything. But in the first episode of that Netflix special, they had that panel. And the one guy, I get what he was lobbying for, you know, this CRISPR technology is being highly regulated with good cause. But we won't know what the implications of it are if we can't test it on healthy people. So I get with the guys coming from but I just feel like you're just asking for shit ton of negative consequences. Kevin 30:35 Yeah, so like anything. So okay, let's let's take the invention of the atom bomb, which was preceded by the splitting of the atom. So when they split the atom, they probably will that the Manhattan Project was built for war purposes. And but I think it's Oppenheimer who ran the project was like, Fuck, you know, basically the cats out of the bag at this point, you know, we A new era is Dawn. And that's absolutely happened. And so the atomic bomb had some noble consequences, which is energy, nuclear submarines more military. So we had nuclear power and things like that. But it came at the consequence of having created the most destructive weapon ever. And so I look at this crisper stuff is going, Hey, this is cool. It has some good here, but it also has the consequence of having potential bio disasters, we could create some sort of biological weapon that can actually annihilate all of us overnight, you know, some virus or something Bob 31:35 almost seamlessly and silently, right. And I think you brought up you brought up Game of Thrones, and I was just thinking about, you know, the, what was that army? The unfallen Kevin 31:48 was this insanely, I believe, on Unix. Bob 31:54 Right, so they could in theory, speaking of the bioengineering Not just like chemical warfare but they could bio engineer people without remorse without you know, appendages that aren't necessarily needed or, or appendages that would tempt them. So or make it so Kevin 32:14 tons or make it so humans are not hermaphrodites and you can actually reproduce asexually and you don't need a mate anymore. He just divide or whatever boy, Bob 32:25 I'm pretty sure the republicans will never let that like I said, we're gonna piss off everybody here today. So Kevin 32:33 hey, if we really want to get this off people abortion, I'm gonna bring up a portion. So you're probably wondering, how does this mix in Well, in a lot of countries and a lot of places, there's pre, there's early pregnancy testing, and some people choose to abort their pregnancies or terminate the pregnancies, whatever the PC version of that is, based on that and so you could look at this as go hey, we Prevent abortions of the that variety. If we can fix it, you know, hey, we say there's a hole in the heart. Let's fix that. We don't have to abort the fetus, right. So there is, you know, I could see people coming. Where am I going with this Can I can see people from both sides of the aisle, you took my Bob 33:19 line. Kevin 33:21 Damn it, I could see people on both sides arguing for and against this is what I'm saying when I say both sides it's the tip. It's the two sides in America people spoiler alert. So I'm not sure how this will come down. Do you see this going any particular way. Bob 33:38 I think that the in womb, genetic defect repair is definitely another one of their sales tactics for this type of technology. But also to go back to your blue I read I you know, cutting that piece of paper so many times that it just shreds I could see that same technique being used for fertility like an on and off bit for fertility. Oh yeah. So you mentioned it with the vasectomy, you know, it could obviously be used for women's reproduction as well. So you basically could go in and instead of being on birth control pills get your DNA edited over a six week course or whatever it is to turn off your reproductive organs and then when you get to a point in your life where you think you're ready to settle down and have a family just go back and get it turned back on the new birth control right hey, I'm young I don't need It's the new everything control unfortunately I that gives rise Kevin 34:35 to Hey, I'm going to take my children down to the clinic turn hit the off button because they get born with it on so I'm gonna hit the off button. Hey kids, you just go be promiscuous as you want to learn about everything. Hey, we've even taken care of HIV. That's not a thing. We turn that off too. So you resistant just go for it. Man. This is getting really weird. Bob 34:56 But I think when you like in going back to the doctor Come again or whatever that is the limited series. It's called Netflix Kevin 35:03 called unnatural selection because I don't think we've set on Bob 35:06 natural selection. Okay, sorry, I meant to name it the first time. But you can go back to unnatural selection. This whole discussion of putting these kits are the ability for these kids to exist in a quote unquote, home lab. I mean, basically, you could start to, you know, there's the people there that were biohacking themselves, but you could most certainly biohack your kids without their consent, though. Kevin 35:31 Really. That'll be the next thing because we already have let's see, it's the HPV virus vaccine that you can give to a tweener. 12 1314 ish. And that's controversial. I mean, heck people by getting the measles vaccine controversy. So, you know, I have Yeah, I have. I have a hard time thinking that this will get very far. However. I think some of the aims of these biohackers is to make it so simple that if it's not legalized There'll be a black market of biohacking out there, kids. You're worried about marijuana worry about people getting genetically modified at this point? Bob 36:09 No, I think that the biohacking movement is well underway. And I mean, body modifications have really transitioned into biohacking to be more permanent in nature. And it comes up and sci fi shows all the time. Oh, so I mean, it's definitely part of culture. And this technology, like I said that one article I found, I think the base regular machine that scientists uses only 10 grand for crisper, and now they've found a way to replicate it for literally pennies. So do you ever watch crime shows like the last 48 or? I try really hard not to Kevin 36:47 so I'll binge watch some of those and just think less of humanity. But a common theme during those shows is the DNA match the results? Well, guess what I do. You know, let's say you murder someone I didn't wanna say I murder someone. Let's say someone murdered somebody. And I bought one of these kippy if you're listening, Bob 37:08 I'm sure Kevin murdered someone. Kevin 37:12 Oh, man, it's weird. Bob 37:13 Let me finish my thought took off his game. Kevin 37:16 So, could you modify your DNA after the crime, and it suddenly no longer match? And now I am able to say, Well, I'm only an 8% match versus the 99.99% match. I didn't By the way, you're not the father. Well, Maury Povich for you. Bob 37:38 Yeah, it's totally gonna mess up the Maury show. Um, but no, I, first of all, huge personal disclaimer here. I've never killed anyone unlike my co Hey, hey, wait, wait, wait, wait. That's not what I meant to say. I don't know from the research that I've read. So I think it's very, very realistic to say, yeah, you could tweak something in be that not 99, nine match. But I don't know how long the course is to make a genetic correction to that. Kevin 38:10 I don't either. Of course, that's during a lot of these talks. And one of the the, I don't know, she's a co founder, but she's one of the names. Her name's Jennifer Doudna. Bob 38:23 Yeah, that actually sounds right. She was, Kevin 38:26 you know, she was on this panel. And she was very upfront and said, hey, look, we can change one gene, we can maybe change a few sequences. And then when the panelists were being asked about these black media type things, well, not yet, but she didn't rule it out. She's like in the future, maybe. But she kind of threw a dose of reality. I think on some of that. I did have another sort of use for this. Imagine your Russia, North Korea, or even maybe United States is they're known to do some door during our Let's say no let's say you had a detainee or a dissident political dissident like China, you know, if you're not part of the party, you're against the party. Could you modify he send them to a, let's just say, we'll just Bob 39:15 go China? Okay. It if Kevin 39:18 could you modify them in a way that would mark them or alter their behavior or some sort of or even like, you know, your truth serum? Hey, turn on these jeans and they will tell a lie, you know, during the interrogation. I mean, there's so many bad things. I think they're gonna come out of this. Bob 39:39 Oh, no doubt. No. Kevin 39:42 All right. I have a question for you, Bob. Okay, if it were safe. And if you had some sort of debilitating thing, hypothetically, would you do it to yourself or would you consult a professional who could perform so Sort of modification to you. Bob 40:03 I think that begs such bigger questions Kevin 40:09 you're so responsible by that's such a responsible answer. Bob 40:14 I think about this all the time, because, you know, I think you and I both do because we're parents, you know, our kids, they're unique and ourselves personally, we're unique because of who we are and in what our circumstances and how we deal with that circumstance. And just like you wouldn't want to say you're defined by fill in the blank. It's still part of who you are. Um, Kevin 40:41 I just don't know. I think I would fear the downside. Like the unknown downside. Yeah. Try to undo something that's already been done for whatever reason, or no, really so but it's done if I were to have surgery, and I've had minor surgery, but you know, I've known people have major surgeries. That's a physical manipulation of the layers above the stack, if you will of DNA, that's a higher order modification, getting your ears pierced getting a tattoo, those are all body modifications to different, you know, extense. So I could see a rash now that DNA modification is just a modification of the body at a different stage of the the diagram, if you will. And if I were dying, and there were a certain cure, and there was, I guess the chances of it working or not, or high or low, but you're saying there's a chance, you know, I might consider it Bob 41:43 right, but that's life or death. I think that there's so many situations where in betweens, right or out of convenience, Kevin 41:52 like being paralyzed, or Bob 41:55 Well, maybe parallel because I think parallel ization definitely contributes to a life or death situation. So there's a saying an injury Kevin 42:04 that is based on life, limb or eyesight. So I think one of those three would definitely rise the level of Hell yeah. Let's try it. However, vanity things such as I have got this freckle right here on my butt or whatever. Can you make it go away but don't use a knife but can you just make it no longer part of my genome and you know stuff like that? I don't think obviously it's worth the risk. But I'm I know people who have you know, those giant where they call it gaged earrings a man. He got frickin coffee cups saucers, his gauges, there you go, man. You go. I'm not that but you that guy would get his freckle removed off his ass. Bob 42:54 Yeah, I wonder if that would work. I don't know. There's just so much you don't know about but he There's one thing that I wanted to make sure that I got to before too long. One of the things that freaked me out in doing this research and I don't know if you saw it, or notice it if you're doing any of the research online, but there are freaking ads. Like I'm staring at one right now. It's in the middle of one of the articles that I pulled up. It's about the the lab that found a way to basically make crisper tools for pennies. There's an ad on the page, it says stop doing crisper for yourself. Order your knockout cell lines. So there are companies that you can pay to fabricate your knockout cells for you. Because apparently that many people are doing at home. There's advertising for it. There's a Kevin 43:46 there's a market for this. Wow. Yeah, well, I wonder if this is kind of looked at by the FDA as like a supplement. This hasn't been tested. This statement has not been tested by the FDA. Good luck Bob 43:58 but I think one of the channels Is that they talk about all the time, is that China? Or maybe it's because it's only regulated at the upper levels and not at the personal level? I don't know. But, you know, one of the arguments is, well, China's way ahead of us in this technology, because it's not as regulated as it is here. The old we gotta get ahead of them. The bad guys, right? Seems to be a very common theme. Unknown Speaker 44:23 So Kevin 44:25 I just want to ponder another potential use of this. So life is very fragile. As far as we know, you need oxygen, you need water. You need you know, place here or you need a space suit. Imagine going to Mars without a space suit. We can genetically modify our astronauts to breathe a very thin atmosphere or we could genetically modify them to breathe methane on one of the moons of Jupiter or Saturn. Of course, there's other problems like pressure suits. I get that don't don't that me but man In, we can modify, you know, humans to travel through the cosmos. Bob 45:06 But all that would require an extreme amount of experimentation, which is the problem right now, Kevin 45:12 like takes me relax. All right click the aliens. What? What? Why? So they're aliens. Okay, so imagine aliens have already had this problem. They want to go visit Earth, but we can't get there because of these biological issues. So what if they've evolved to the point where they now can do their own DNA splicing and editing and they've modified their bodies so that they got big, black guys and their small bodies and they're gray and they're very smart, and they can travel across the cosmos? Maybe maybe aliens already doing this Bob? What do you think? Bob 46:00 I'm going to guess they probably have better genetic code to start out with. That's what I'm going to guess. All right, so they live in a society where the genetic modification of their organism is an accepted norm. And they bioengineer themselves to suit whatever Next, you know, Global Mission they have. Kevin 46:27 All right, so we've always heard of things like intelligent design versus evolution, right, tell Joe is gonna piss off everyone. Right? So, so intelligent design is basically the idea that humans started out as humans, they did not evolve to humans were evolutions. Basically. We started it in a petri dish, you know, a little swamp and then eventually became humans over millennia. So what if humans were actually designed by a And I keep bringing this back. I'm sounding really like tinfoil hat. I apologize to everyone. But what if humans were dropped here as an experiment, or monkeys, or apes or chimps, if you will, we're here. And then they're like, hey, let's take our own DNA and take these bipedal organisms with arms, and let's combine it with our own DNA and just leave them here. And we're some lab experiment that they're checking in on us every now and then. Bob 47:28 Well, I think that's a definitely a common argument for a lot of technological advance. It's either the simulation argument or that, you know, we're the experiment of an alien race. But I don't know if that addresses or solves just because can does that mean we should kind of I think, which is the original premise of you know why we're talking about this, right? Kevin 47:56 Right. Oh, for sure. Because for me, this sounds like a James Bond. Movie plot at this point where you got the evil you know, the the antagonist is totally like building this genetically enhanced army or building a bio weapon, or God knows what the thing is, is I think this crisper thing is flirting with the hubris of humanity. And I think it's this innate thing that we have, especially as parents that we want to create life and you know, programmers want to create artificial intelligence, and you got the whole gamut of things. And it always comes back to what you said which is just because we can should we and I am on the fence at this point because I can see the potential good for it but I am right now the bad luck so overwhelming. How do you feel about it? Bob 48:48 Well, I think the bad looks so unknown, which makes it overwhelming, but I'm also super intrigued that I didn't think of this and you brought it up with the the AI the machine learning And then we can even tie this back to bad bias to, I can see it going toward analysis of data, ai determining what the perfect gene sequence looks like. And then the system of splice is done with crisper to get some one person to that point. And, you know, depending on the garbage that goes into that, ai analysis, the output could be terrible. Yeah, Kevin 49:33 we can end up with nothing but zombies, a bio weapon that just inadvertently kills everyone. Or we could end up with a great future. But the thing is, it's like, it's like counter terrorism, you have to account for the 99 things that they can do to hurt you and they only have to be successful once, right? So I look at this as going for the one thing or the few things that it looks like it could be good for. I also see that Listen, the downside of this and that I don't know if it really scares me yet because it's it's more academic papers and there's a couple cases out there at this point. But as they mentioned in one documentary in the 70s, they had okay computers, but they knew they would have better computers one day. Well, right. I think the same thing applies here. They have pretty okay technology with gene editing. Now, we know in the future, it'll probably only get better. Bob 50:31 Okay. Unknown Speaker 50:33 What do we forget? Bob 50:35 Well, I think it'd probably be a little bit remiss to not mention that I think we're both in agreement here that regardless of the outcome, I think the the technology itself, in the research that's, you know, been put into this, this problem that needs to be solved, apparently of, you know, splicing genes in figuring out that you could use a Protein x is a virus to basically do the work. It's pretty impressive. I mean, it's a very impressive Oh, Unknown Speaker 51:07 it like who who thinks of this shit. Kevin 51:08 I was reading some of the Wikipedia articles and trying to make sense of it. And I just said, I'm glad I'm a programmer. I'm not a biologist, because I don't know what's going on here. Bob 51:19 It feels like it crosses over into programming a little bit, though, with the, you know, the sequence and the wirings. And the knowing how do I like developing a technique for identification of the bad sequence, and then the replacement or the reorganization or removal of that sequence? It's just crazy. Kevin 51:38 Yeah, it's kind of like the chemical version of Find and Replace. Bob 51:43 Yeah, it's, Kevin 51:45 like you said, and that's and and for non programmers, programmers out there. regex is stands for regular expressions, and there's nothing regular about them. It's just a fancy way of pattern matching. Bob 51:55 No way. You could totally find the pattern in anything. So Kevin 52:00 I'm going to watch more of unnatural selection on Netflix because it's a little short series I haven't made it through all the way there's some good videos on YouTube regarding crisper and whatnot. I've probably pissed off science people can conservationist religious types, but I just wanted to do a kind of throw out there all the angles and definitely got in some chops for aliens are probably Bob 52:28 probably not putting that in the title but hey, and for anyone that's still listening, if you've got thoughts on this, interestingly, we got well Kevin because of course he puts all of his good tweets on his own Twitter account. Got some pretty good engagement on talking about that we were going to be talking about this on the show today. So if you did listen, obviously we gave this a 30,000 foot cuz Hey, we're not biologist be we're not scientists, but it's a technology topic that I think is There's gonna be more and more Unknown Speaker 53:02 brought to the forefront as these days tick by so let us know what you think on it, for sure. Kevin 53:09 All right, Bob, I think we're good to go. This is good, good, good stuff. I'm sure we'll have more to follow as the technology develops Unknown Speaker 53:17 and or as zombies approach my front door. Bob 53:22 Just Just remember kids don't give your DNA to any of the online stores for DNA and maybe don't modify it with it at home crisper kit. Unknown Speaker 53:33 Yeah, just say no kids. Unknown Speaker 53:38 Hey, have you ever wondered how you can get in touch with us at the Bob and Kevin show? Well, first, you can try us via email and comments at Bob and Kevin show calm or are you more into social? If so you can find us on Twitter at Bob and Kevin show or on Instagram, as Bob e Kevin show. That's Bob. The letter M Show Unknown Speaker 54:00 and if you're still on Facebook, you can even find Unknown Speaker 54:03 us@facebook.com slash Bob and Kevin show and for the serious business fans, you can even find us on linkedin@linkedin.com slash company slash the dash Bob dash Kevin dash show. How's that for a handle? Let's connect Transcribed by https://otter.ai

Judge Stan Boone, Angela Storey, Stephen Tollafield, and Josh Gilliland conduct their legal review of what goes bump in the night. Recorded live at SVCC 2019, this panel discussed Frankenstein's Creature, lynch mobs, the Mummy, cruel and unusual punishment, endangered species with the Creature from the Black Lagoon, and peeping toms with the Wolfman. Support the show (https://www.patreon.com/thelegalgeeks)

What is up everyone! Happy October, and we are back with another episode of your favorite podcast, Mind.Erase.MediaCast aka M.E.MCast. In this episode, Ray (@rayhomdotcom) sits with Vince Mostajo (@vmostajo09) from 'Keeping It Nerd' (@keepingitnerd). They discuss the beginnings of 'Keeping It Nerd', how Ray still can't catch up to Kevin Smith, getting to podcast at Silicon Valley Comic Con, and collecting toys, even until today...as grown adults. #DontJudgeUs As always, hit up MindEraseMedia.com for all the latest and greatest that Mind.Erase.Media has to offer, and don't forget to rate, comment, and subscribe on the Apple Podcasts and wherever you get your podcasts. Tell erryone about dis right here! And Here...We...GO!!! Music - Introduction: Smith the Mister - Ohayo (https://soundcloud.com/smiththemister) Main Theme: Take/Five - Breakaway (https://soundcloud.com/takefivemusic/)

Stone Cold Steve Austin is a WWE Hall of Famer that main evented several WrestleManias, Summer Slams and so much more. He truly is an icon of professional wrestling. Hear his panel from Silicon Valley Comic Con on today's show!

We debuted this show 3 years ago at a brand new convention, with no idea how this would go. Well now we're back, and we're ragier than ever! Find out if Ant-Man going through Thanos's exhaust port is a good idea, which Star Trek crew would make the best D&D party and more! Taking it back to where it all began! It's our third year at Silicon Valley Comic Con, the birthplace of Nerd Rage! Catch "Nerd Rage: LIVE" at the Oakland Comedy Festival, October 19th! Produced by Komedio Comedy Find more episodes of Nerd Rage! The Great Debates at NerdRagePodcast.com (http://nerdragepodcast.com/) To stay informed on Komedio live shows and podcasts visit Komed.io (http://komed.io/) ✉️ e-Mail us at KomedioComedy@gmail.com (put “Nerd Rage” in the subject line) Find us @NerdRageTGD (https://twitter.com/nerdragetgd) on Twitter or follow us on Facebook (https://www.facebook.com/nerdrageTGD/) for more updates. Special Guests: Alexandria Love, Becca Henry, Hayden Greif-Neill, Imran G, Kristee Ono, Stephen Ku, and Tirumari Jothi. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The guys took over Silicon Valley Comic Con 2019. Vince (@vmostaj09) & Jeremiah (xjdempseyx) were all over the place and in this episode they go over their experience. The  show was able to participate in Podcastpalooza ( a battle of the bands of sorts ), conduct interviews with the founders of Legion M, (Jeff Annison & Paul Scanlan), the director of "Memory: The Origin of Alien", Alexandre Philippe and manage to navigate through the convention floor checking out the sights and sounds of what this years SVCC was able to offer. Special Thanks to: Silicon Valley Comic Con, Westwood One, Subnation for having us on stage for the podcastpalooza Jeff Annison, Paul Scanlan and Alexandre Philippe for lending us their time to share with us their passions and projects Gameboy Jones and Caliberbeats for the official song of this podcast. (@gameboyjones on Instagram and www.caliberbeats.com) Please like, rate, comment, subscribe on Apple Podcasts, Google Play Music, Stitcher Radio and Spotify.

It's a Brand New Week and that means a New Episode of Nerd Rage Weekly is here! This week's show has a lot to discuss. Ryan and Brad talk Obi-Wan returning for a new series, rumors about upcoming Disney/Marvel shows, Titans returning for Season 2, and and a whole mess of trailers to discuss! This week's The Big Talk is all about the drama between Sony and Disney over the rights to the Spider-man character and where we go from here. Thanks to those of you that met us at Silicon Valley Comic Con! We hope you enjoy this episode, and be sure to watch our social media streams for updates on more new episodes! The News: 00:00 - 109:54 The Big Talk: 109:55 - 135:06 Rage On!

Clint, Steve and Skip back again! After catching up, they talk Skip's trip to Silicon Valley Comic Con, everything D23 and Disney+, Marvel Land, Moana, Epcot, Frozen 2, Raya and the Last Dragon, Soul, WandaVision, The Mandalorian, Lady & The Tramp, The Muppet Show, Moon Knight, She-Hulk, Ms. Marvel, Obi-Wan series, Black Widow wears white, Matrix 4, Joker's R-rating and our hopes, AHS 1984, GameStop lays off 120+, Final Fantasy 8 Remastered, closings & plugs, and much more!

On this episode: - Rob and Mike recap their recent appearance at Podcast Palooza at the Silicon Valley Comic Con      - Lessons learned from professional COS Players and Mike gets a memorable surprise from someone dressed as "Slave Leia" - Cell phones and their effects on your kids      - What do they actually do to your kids?      - Cell phones in the classroom?      - A sensible approach to getting a cell phone for your kid when it's the right time - Rob thinks that Mike is addicted to his cell phone and wants to stage an intervention... - Bad Dad this week is actually doing the right thing and we're torn on the subject   Have comments, suggestions or just want to say, "Hi!"?  Have an embarrassing fact that you want to learn about Mike?  Email us at thestandupdads@gmail.com  Find us at https://standupdads.podbean.com/ or on facebook @standupdadspod Find Mike's site at https://pencilforhire.myportfolio.com/ Find Big Nick's Gag on This Podcast at https://gagonthis.podbean.com/   Links to the videos and articles mentioned in the show are below: https://sanfrancisco.cbslocal.com/2019/08/19/locked-pouches-keep-cellphones-out-of-students-hands-at-san-mateo-high-school/ https://www.nbc26.com/news/national/stunning-results-after-researchers-look-at-effects-of-cell-phones-on-kids-national https://education.cu-portland.edu/blog/classroom-resources/pros-and-cons-of-allowing-digital-devices-in-the-classroom/ https://childmind.org/article/when-should-you-get-your-kid-a-phone/ https://www.yahoo.com/news/dad-arrested-for-taking-daughters-phone-as-171354368.html https://www.youtube.com/watch?v=MGhYSKqrcdo https://www.facebook.com/watch/?v=1590464244413119 http://www.cc.com/video-clips/v0m2s9/comedy-central-presents-guy-on-a-cell-phone https://vimeo.com/69662330   Thanks for listening!

Tune in as the nerdy boys catch up, talk about podcasting live at Silicon Valley Comic Con, and break down the latest nerdy news including the latest from D23 Expo and the Sony/Disney Spider-Man deal debacle.  Facebook: Facebook.com/NerdyBoysReviews Instagram: @nerdyboysreviews Twitter: @NerdyBoysReview Youtube: UChpqtJ4n27PHX8G3rjZ-jZA Website: Nerdyboys.weebly.com

The Comic Bookies took a week off, but for good reason. Listen in to our review of our podcasting experience at Silicon Valley Comic Con. We also hit on House/Powers of X and the horrible Spider-Man news. On the sports side, two more NFL divisions and college conferences to preview, as well as a little EPL. 

The Nerds head to San Jose California to check out Silicon Valley Comic-Con. We sit down with the Legion M co-founder and president Jeff Annison and VP of Development David Baxter and discuss how Legion M is changing the way movies are made. We also get to talk with Luke Gygax, son of D&D creator Gary Gygax, and discuss how Dungeons and Dragons changed the nerd world forever. Big thanks to Legion M and Luke Gygax for taking the time to sit down with us. Enjoy the show!

In this episode, we recap Silicon Valley Comic Con 2019. We discuss the highs and lows of its 4th year, and our impressions of the San Jose convention. Help support Panel to Panel: www.patreon.com/paneltopanelpodcast www.ko-fi.com/paneltopanel Hit up the Panel to Panel team at: paneltopanelpodcast@gmail.com  Twitter @paneltopanelpod Instagram @paneltopanelpodcast

This week your heroes welcome back the one, the only ParmAlarm James Navarro. They give you an inside look at their experience at Silicon Valley Comic Con and the amazing organization Project Wish Upon A Star. Buddy and Shmee get heated about the Disney/Sony Spider-man news, and they also sing way too much for anybody's comfort.

Ruben just talks about Silicon Valley Comic Con for a while. Merch: www.teepublic.com/user/ktmashow Discord: discord.gg/s5PGttd Wanna suggest a theme? Wanna have your business talked about on the show? Do people even read the descriptions? - ktmashow@gmail.com We have a Patreon! www.patreon.com/KTMAshow Follow us on Facebook and Twitter! www.facebook.com/ktmashow www.twitter.com/ktmashow Music and Logo by Brandon Gross of Better Promises

This weekend I tried to take a trip to SVCC 2019 in San Jose, CA. However, I was unable to spend all three days there, actually - not even one full day - as I had to B-line to my sister's house for babysitting duty while she gave birth to my beautiful new niece! All-in-all an amazing weekend! So, in this shortened episode (recorded Sunday night at midnight), we'll go over my brief time at SVCC which was awesome while it lasted. There I hung out with Dave of GeekFineArt and author of "The Chronicles of Royal High: The Lost Noble" Rachel Litfin! We also go over some nerd news, watch a couple trailers, and announce a big weekly giveaway!Thanks for listening! Give us a follow and a review on any podcast app! If you liked our content, we'd love to hear from you. You can comment on one of our YouTube videos/ IG posts, or even DM us! Thank you all!!QUESTION OF THE DAY — What's your next Comic Con going to be?Support the show (https://www.youtube.com/c/downrightnerdypodcast)

It was Me! This week Chris and Daniel discuss JLA: Tower of Babel by Mark Waid, Howard Porter, and Steve Scott. We also talk about Ewan McGregor's return as Obi-Wan Kenobi, new Marvel shows on Hulu, and a recap of our live show at Silicon Valley Comic Con. Visit us online: https://thereadercopypodcast.libsyn.com/ ( Check out The Reader Copy Podcast website)   Our iTunes page: https://goo.gl/MikhDd ( Listen to more episodes)   Even More Stuff: https://goo.gl/4iDTXn ( Check out our Instagram) https://goo.gl/cVFw7r ( Follow us on Twitter) https://goo.gl/RsnXc1 ( Like us on Facebook)   Show music provided by MDK - Hyper Beam

It's a New Week and that means a New Episode of Nerd Rage Weekly! This week's show has something for everyone! Ryan and Brad discuss the future of Superman, rumors regarding The Eternals, John Wick getting a spinoff, and so many trailers it'll make your head spin! Be sure to come our to Silicon Valley Comic Con this weekend if you're in the Northern California area, as Ryan will be doing interviews and handing out merchandise for any of our fans in attendance. We hope you enjoy the show, and be sure to watch our social media streams for updates on more new episodes! The News: 00:00 - 76:00 The Big Talk: 76:01 - 95:58 Rage On!

What's Up Everybody!? We're currently enjoying Silicon Valley Comic Con this weekend, but we thought we'd share our thoughts on another big comic con reveal, Marvel's "What If" series! Before the new series appears on Disney's new Disney+ streaming service, Brad and Ryan thought they'd share their ideas from both live action and the comics as to what "What If" episodes they'd like to see when the show premieres. Enjoy our nonsense and let us know what stories you'd like to see from Marvel's What If. We have a lot of great episodes and new material coming for Underwear On The Outside and we can't wait to share it all with you! Have an awesome weekend!

We jump through a wide-range of topics this week, including favorite movie analysis videos, deaging effects, and the details on the North Bergen High School drama class Alien spacesuit. Plus, Will recommends the glass blowing competition show Blown Away and we talk about what kinds of competition shows we like. Next weekend we'll be at Silicon Valley Comic Con!

We discuss Silicon Valley Comic Con 2017 Con Highlights, Celebs, Cosplay and Comedy. I'm joined by a roundtable including Scott Sebring, Vickie Sebring, Kelly Delcambre, Valerie Perez and Alex Murphy.

Off the heels of a successful debut at San Francisco's PianoFight, Nerd Rage: TGD is celebrating with another hilarious compiliation of live show highlights from Marc Abrigo, himself. In this episode, we go back to Komedio's Silicon Valley Comic-Con debut for Nerd Rage's FIRST-EVER debate where we tackle being a Pokemon trainer versus having a 9-5 day job. We then take a stroll down memory lane with Nerd Rage's first time in Indianapolis' GenCon 50 for a PC/console kerfuffle, and finally, witness a no-holds-barred free-for-fall between EIGHT ragers at San Francisco Comic-Con 2018. Guess who's back... back again... Marc is back... with no friends... so let's get ready to RAGE! Produced by Will Scovill & Komedio Comedy Find more episodes of Nerd Rage! The Great Debates at NerdRagePodcast.com (http://nerdragepodcast.com/) Stay informed on Komedio live shows and podcasts visit Komed.io (http://komed.io/) ✉️ e-Mail us at KomedioComedy@gmail.com (put “Nerd Rage” in the subject line) Find us @NerdRageTGD (https://twitter.com/nerdragetgd) on Twitter or follow us on Facebook (https://www.facebook.com/nerdrageTGD/) for more updates. Special Guests: Alexandria Love, Anica Cihla, Austin Blaylock, Jordan Ranft, Kristee Ono, Mike Drucker, Stephen Ku, Tirumari Jothi, and Wonder Dave. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

It's been two months of craziness in Stan's life since our last video covering the strange things happening to this 95 year-old Marvel legend. This is an update on things happening since, that include the following: Fraud charges, elder abuse, heist, bribery and now an arrest followed by a restraining order. Join us in the discussion. Keya Morgan is Mephisto. Sign up for the Mystery Mail Call: Geekstreet101.com Social Media - INSTAGRAM: @comictom101 TWITTER: @comictom101 FACEBOOK: @comictom101 SNAPCHAT: @comictom101 Need a Local Comic Shop? Contact Russ: MillGeekComics@gmail.com Follow Russ on IG @millgeekcomics Editing, Producing, Animation Credit (Logo & Outro): Slava Shatilov https://www.facebook.com/slava.shatilov Logo Credit: Adam English canalsidecaricatures.com Outro Beat Credit: https://www.facebook.com/waveworksmusic/ DISCLAIMER THIS VIDEO IS FOR ENTERTAINMENT PURPOSES AND THE INFORMATION PRESENTED IS IN A COMEDIC AND INFORMATIVE FASHION. THIS INFORMATION PRESENTED DOESN’T REFLECT THE INDIVIDUALS BEING DISCUSSED. PLEASE DO NOT SEND NEGATIVE REMARKS TO ANY BUSINESS AND/OR PEOPLE DISCUSSED. THANK YOU Category People & Blogs License Standard YouTube License SOURCES: Kiss & Stan Blood: https://www.youtube.com/watch?v=V-Wpjcv-MqQ Kia Restraining Order/Elder Abuse: https://www.bleedingcool.com/2018/06/14/stan-lee-restraining-orders-keya-morgan-swatted-police-elder-abuse/ Fan’s express concern at Silicon Valley Comic Con, @comicbooks22 pictures and video: https://www.bleedingcool.com/2018/04/08/concern-stan-lee-silicon-valley-comic-con/ Stan Lee Sexul Assult Alligations: Dailey Mail 01-09-2018 http://www.dailymail.co.uk/news/article-5250513/Marvel-creator-Stan-Lee-95-accused-groping-nurses.html 300,000 Check Forged, TMZ Breaking News: http://www.tmz.com/2017/12/29/stan-lee-forged-check-police-report/ Stan Lee Fires Max Anderson, Nurse and others. 1.4 Million goes missing http://www.dailymail.co.uk/news/article-5428459/Stan-Lees-longtime-manager-fired-honeytrap-claims.html Hollywood Reporter, Elder Abuse? Declaration and up to date (04/11) https://www.hollywoodreporter.com/features/stan-lee-needs-a-hero-elder-abuse-claims-a-battle-aging-marvel-creator-1101229 Todd visits Stan https://www.cbr.com/mcfarlane-stan-lee-story/

Talking about Silicon Valley Comic Con!!!

Part 2 - Welcome to Episode 16 of Bags and Boards! I sit down with Ryan Sargeant and discuss an incident that happened at Silicon Valley Comic Con in early April 2018 with Stan Lee, his team and a fan getting things signed! An Amazing Spider-Man #14 gets damaged and Stan Lee ended up paying for it! After getting the story from the IGCOMICFAMILY member and seeing his experience showcased in Bleedingcool’s recent article (all sources below) on fan’s being concerned about Stan’s well-being, we decided to compile as much information as we can to get an understanding of what is going on. It’s incredibly alarming, strange and concerning. Thank you @Comicbooks22 for giving us permission to share your video and photos, he’s got a great IG, go check him out! Social Media - INSTAGRAM: @comictom101 TWITTER: @comictom101 Facebook: @comictom101 Snapchat: @comictom101 Animation Credit (Logo & Outro) Editing, Producing: Slava Shatilov https://www.facebook.com/slava.shatilov Editing, Producing: Ryan Sargeant @sirsargeant Logo Credit: Adam English canalsidecaricatures.com Outro Beat Credit: https://www.facebook.com/waveworksmusic/ SOURCES: Fan’s express concern at Silicon Valley Comic Con, @comicbooks22 pictures and video: https://www.bleedingcool.com/2018/04/08/concern-stan-lee-silicon-valley-comic-con/ Stan Lee Sexul Assult Alligations - Dailey Mail 01-09-2018 http://www.dailymail.co.uk/news/article-5250513/Marvel-creator-Stan-Lee-95-accused-groping-nurses.html 300,000 Check Forged, TMZ Breaking News: http://www.tmz.com/2017/12/29/stan-lee-forged-check-police-report/ Stan Lee Fires Max Anderson, Nurse and others. 1.4 Million goes missing http://www.dailymail.co.uk/news/article-5428459/Stan-Lees-longtime-manager-fired-honeytrap-claims.html Hollywood Reporter, Elder Abuse? Declaration and up to date (04/11) https://www.hollywoodreporter.com/features/stan-lee-needs-a-hero-elder-abuse-claims-a-battle-aging-marvel-creator-1101229 Todd visits Stan https://www.cbr.com/mcfarlane-stan-lee-story/ DISCLAIMER THIS VIDEO IS FOR ENTERTAINMENT PURPOSES AND THE INFORMATION PRESENTED IS IN A COMEDIC AND INFORMATIVE FASHION. THIS INFORMATION PRESENTED DOESN’T REFLECT THE INDIVIDUALS BEING DISCUSSED. PLEASE DO NOT SEND NEGATIVE REMARKS TO ANY BUSINESS AND/OR PEOPLE DISCUSSED. THANK YOU

Part 1 - Welcome to Episode 16 of Bags and Boards! I sit down with Ryan Sargeant and discuss an incident that happened at Silicon Valley Comic Con in early April 2018 with Stan Lee, his team and a fan getting things signed! An Amazing Spider-Man #14 gets damaged and Stan Lee ended up paying for it! After getting the story from the IGCOMICFAMILY member and seeing his experience showcased in Bleedingcool’s recent article (all sources below) on fan’s being concerned about Stan’s well-being, we decided to compile as much information as we can to get an understanding of what is going on. It’s incredibly alarming, strange and concerning. Thank you @Comicbooks22 for giving us permission to share your video and photos, he’s got a great IG, go check him out! Social Media - INSTAGRAM: @comictom101 TWITTER: @comictom101 Facebook: @comictom101 Snapchat: @comictom101 Animation Credit (Logo & Outro) Editing, Producing: Slava Shatilov https://www.facebook.com/slava.shatilov Editing, Producing: Ryan Sargeant @sirsargeant Logo Credit: Adam English canalsidecaricatures.com Outro Beat Credit: https://www.facebook.com/waveworksmusic/ SOURCES: Fan’s express concern at Silicon Valley Comic Con, @comicbooks22 pictures and video: https://www.bleedingcool.com/2018/04/08/concern-stan-lee-silicon-valley-comic-con/ Stan Lee Sexul Assult Alligations - Dailey Mail 01-09-2018 http://www.dailymail.co.uk/news/article-5250513/Marvel-creator-Stan-Lee-95-accused-groping-nurses.html 300,000 Check Forged, TMZ Breaking News: http://www.tmz.com/2017/12/29/stan-lee-forged-check-police-report/ Stan Lee Fires Max Anderson, Nurse and others. 1.4 Million goes missing http://www.dailymail.co.uk/news/article-5428459/Stan-Lees-longtime-manager-fired-honeytrap-claims.html Hollywood Reporter, Elder Abuse? Declaration and up to date (04/11) https://www.hollywoodreporter.com/features/stan-lee-needs-a-hero-elder-abuse-claims-a-battle-aging-marvel-creator-1101229 Todd visits Stan https://www.cbr.com/mcfarlane-stan-lee-story/ DISCLAIMER THIS VIDEO IS FOR ENTERTAINMENT PURPOSES AND THE INFORMATION PRESENTED IS IN A COMEDIC AND INFORMATIVE FASHION. THIS INFORMATION PRESENTED DOESN’T REFLECT THE INDIVIDUALS BEING DISCUSSED. PLEASE DO NOT SEND NEGATIVE REMARKS TO ANY BUSINESS AND/OR PEOPLE DISCUSSED. THANK YOU

#31 Jerry Mathers (Leave It to Beaver) talks about his career and what he's been up to, Silicon Valley Comic Con, Infinity War, Spider Man PlayStation his new suit that he wears is awesome, Disney New Movies we have the list for 2018.

#31 Jerry Mathers (Leave It to Beaver) talks about his career and what he's been up to, Silicon Valley Comic Con, Infinity War, Spider Man PlayStation his new suit that he wears is awesome, Disney New Movies we have the list for 2018.

Over the past few months, as part of our coverage of a number of conventions (such as Silicon Valley Comic Con and Wonder Con Anaheim), we have been lucky enough to have had the chance to participate in the promotion for the upcoming film BAD SAMARITAN, starring David Tennant (Cale) as a privileged and preening socialite with the darkest of secrets and Robert Sheenan as the restaurant valet who, through the act stealing from Cale, finds himself on a collision course of sheer will and violence. Directed by Dean Devlin and written by Brandon Boyce, we have been most intrigued by the funding and distribution of the film, based on the innovative model put forward by Legion M, a crowd-sourced collective in which the investors into the pot are all , effectively, the eventual producers of the final product and can claim ownership for the films existence - it's an exciting business model, allowing for films, TV series, comic books and all kinds of content to belong outside of the conventional Hollywood distribution model. A 'brave new world', indeed. AESID Correspondent Dan Berry has been our man on the ground at these events and, as a consequence of that, was invited along to the London West Hollywood Hotel at Beverly Hills to take part in a press conference for BAD SAMARITAN with Devlin, Boyce, Tennant and Sheehan in attendance. Dan recorded the session, along with taking a couple of cracking shots for posterity - enjoy!

Hear Mads Mikkelsen talk about his time playing the iconic Hannibal Lecture as well as villains in Dr. Strange and Casino Royale in this conversation from Silicon Valley Comic Con! Also, Mads touches on working on Rogue One and if there will ever be a conclusion to the Hannibal Story.

In our final pop-up podcast recording from Silicon Valley Comic Con, we welcome Evan Narcisse, senior writer at io9 and writer of the current Marvel mini-series Rise of the Black Panther! Evan talks about how he went from being a fan to writing comics, his take on the origin story of Black Panther, and collaborating with artists to tell this new story.

This week, Dave and Jeff take you to Silicon Valley Comic Con 2018 for an in-depth report. Marvel legend Stan Lee made a three-day appearance that was painful to witness, and we discuss the fallout. Celebrities pose, scientists expound and vendors vend all weekend, and Mousetalgia shares some highlights. Margaret Kerry flew in to meet her Tinker Bell fans, the 501st looked for recruits for the Empire, and everybody was just "Wookie-ing for the Weekend" as the event kicked off with a Star Wars panel with Mads Mikkelsen, Daniel Logan, Temuera Morrison and Ray Park. Plus - a listener review of art exhibits in the OC, and we choose our own super powers.

In this Mini Episode, Steve & Izzy talk about their three-day weekend in San Jose at Silicon Valley Comic Con 2018!!! Who did they meet? Who did they touch? Who's going to be on a future podcast? What were the nachos like? Find out all this & more!!!

Bryan, Bill Z and Steve are back on the mic to offer up to you a solid hour and a half of comic book and comic related talk.  We cover recent comic culture news such as the concerns for Stan Lee after his appearance at the Silicon Valley Comic Con and the controversies over the recent 99 cents Marvel sales on Comixology.  We then turn on the tube and talk about what is happening with Legion, Legends of Tomorrow, SHIELD and Krypton. Finally we lope on over to the spinner rack and talk about Dark Knights: Metal, Brilliant Trash, Snagglepuss, The Terrifics, Lockjaw and more!

SVCC 2018: In Conversation with Fanbase Press (Bryant Dillon), Silicon Valley Comic Con April 2018 In the weekend of April 6th-8th in San Jose, Silicon Valley Comic Con took over the Convention Center of the city to bring a show that fuses both pop culture with the best of science and technology. Attending the show was our 'man on the ground', Dan Berry who got to speak to a host of incredible creatives and exhibitors. Here, Dan speaks to Top Cow Press' CCO Matt Hawkins about what makes Top Cow stand out from the herd in 2018, as well as his current line-up of book,s what Top Cow have got planned down the line, and what is in store for Matt as he takes Top Cow across the globe... Thanks to Matt for his time at the show, and thanks to Dylan Gray of Top Cow and to Dan for bringing us this interview.

We welcome author Andy Weir back on Tested, as we catch up with him in this pop-up podcast recording at Silicon Valley Comic Con. Andy talks about the research behind his most recent book Artemis, the best way to build cities on the moon, and why he prefers post-apocalpyse to dystopia.

In this episode, we recap Silicon Valley Comic Con 2018, and some of the new elements and issues that came along with this third year event.. Help support Panel to Panel: www.patreon.com/paneltopanelpodcast www.ko-fi.com/paneltopanel Hit up the Panel to Panel team at: paneltopanelpodcast@gmail.com Twitter @paneltopanelpod Instagram @paneltopanelpodcast

This week Chris and Skip talk about our experience at Silicon Valley Comic Con, discuss the proper manner to viewing moose, and mull over the new Xbox One backward compatible titles. Thanks for listening! Enjoy. Deficit Picks of the Week: Jaws III We rate and review: Wild, Wild Country (Cock) Blockers A Quiet Place Atlanta We smoke: Black Jack Gorilla Glue We open with Dog Eat Dog by Adam Ant, have an interlude with I’m a Telly Addict by Toy Dolls and close with by. Follow us on Twitter @adoradio0 or @M_ADOradio or @Skip_ADO_Radio. We're a proud member of the BAT SQUAD network (www.batsquadnetwork.com). Make sure to check out the other great shows! What?

In this episode, the gang discusses Silicon Valley Comic Con 2018, and make predictions for the upcoming Blockbuster event INFINITY WAR

Welcome to Episode 16 of Bags and Boards! I sit down with Ryan Sargeant and discuss an incident that happened at Silicon Valley Comic Con in early April 2018 with Stan Lee, his team and a fan getting things signed! An Amazing Spider-Man #14 gets damaged and Stan Lee ended up paying for it! After getting the story from the IGCOMICFAMILY member and seeing his experience showcased in Bleedingcool’s recent article (all sources below) on fan’s being concerned about Stan’s well-being, we decided to compile as much information as we can to get an understanding of what is going on. It’s incredibly alarming, strange and concerning. Thank you @Comicbooks22 for giving us permission to share your video and photos, he’s got a great IG, go check him out! Social Media - INSTAGRAM: @comictom101 TWITTER: @comictom101 Facebook: @comictom101 Snapchat: @comictom101 Animation Credit (Logo & Outro) Editing, Producing: Slava Shatilov https://www.facebook.com/slava.shatilov Editing, Producing: Ryan Sargeant @sirsargeant Logo Credit: Adam English canalsidecaricatures.com Outro Beat Credit: https://www.facebook.com/waveworksmusic/ SOURCES: Fan’s express concern at Silicon Valley Comic Con, @comicbooks22 pictures and video: https://www.bleedingcool.com/2018/04/08/concern-stan-lee-silicon-valley-comic-con/ Stan Lee Sexul Assult Alligations - Dailey Mail 01-09-2018 http://www.dailymail.co.uk/news/article-5250513/Marvel-creator-Stan-Lee-95-accused-groping-nurses.html 300,000 Check Forged, TMZ Breaking News: http://www.tmz.com/2017/12/29/stan-lee-forged-check-police-report/ Stan Lee Fires Max Anderson, Nurse and others. 1.4 Million goes missing http://www.dailymail.co.uk/news/article-5428459/Stan-Lees-longtime-manager-fired-honeytrap-claims.html Hollywood Reporter, Elder Abuse? Declaration and up to date (04/11) https://www.hollywoodreporter.com/features/stan-lee-needs-a-hero-elder-abuse-claims-a-battle-aging-marvel-creator-1101229 Todd visits Stan https://www.cbr.com/mcfarlane-stan-lee-story/ DISCLAIMER THIS VIDEO IS FOR ENTERTAINMENT PURPOSES AND THE INFORMATION PRESENTED IS IN A COMEDIC AND INFORMATIVE FASHION. THIS INFORMATION PRESENTED DOESN’T REFLECT THE INDIVIDUALS BEING DISCUSSED. PLEASE DO NOT SEND NEGATIVE REMARKS TO ANY BUSINESS AND/OR PEOPLE DISCUSSED. THANK YOU

As Mark Zuckerberg testifies to congress, we get together to talk about Facebook privacy concerns, this past weekend's Silicon Valley Comic Con, the new Solo trailer, and more! Plus, a moment of science and the VR minute!

Keeping It Nerd rocked the house during Silicon Valley Comic Con at Caffe Frascati on April 7, 2018. Our heroes, Vince (@vmostajo09), with help from Anthony (@murseant), hosted the all-star panel this past weekend in a little cafe down the street from the San Jose Convention Center. Our panelists included artist and actress Lauren Garcia (@lasandrei), filmmaker and podcaster Ray Hom (@rayhomdotcom), comic artist Glen Canlas (@glencanlas), and personal trainer and cosplayer Saul Cervantes (@spideyfit). They each brought their awesome energy and their intelligent insights on all things pop culture and geek related. They all go into depth about what they like in the pop and geek culture, why we will always see the 80s style in modern times, and what superpowers each of the panelists have. We were also treated to a dramatic reading of everyone’s least favorite Marvel Netflix series, ‘Iron Fist.’ Special Thanks: – Roger and Caroline from Caffe Frascati. Go check them out at 315 S. 1st St., San Jose, CA. – Each of the panelists! Lauren, Ray, Glen, and Saul. – Edwin Fabian aka Marty McFLY **buzz buzz** for the promo – Alec Rivera for taking the pictures – As always, Evan King (http://evanking.bandcamp.com) for “Alpha Channels”, the official theme of ‘Keeping It Nerd’ heard on this and almost every episode of this very fine podcast. Please rate, comment, and subscribe on Apple Podcasts, Google Play Music, and on STITCHER Radio. Email: keepingitnerdpodcast@gmail.com Socials: @keepingitnerd Web: keepingitnerd.com Music: Nicolai Heidlas – “Good Times” Topher Mohr & Alex Elena – “Festival”

Our heroes enter the ancient city of San Jose, California for Silicon Valley Comic-Con. On this episode minus Anthony (for the actual Comic Con), Vince (@vmostajo09) and Reyna (@reynax81) discuss why the Bay Area doesn’t need WonderCon, the amount of merchandise that one can find at one of these conventions, and Instagram cosplayer stalking. And the heroes encounter one of the Guardians of the Galaxy and a Rick and Morty Szechuan Sauce (@edwinfabian). The adventurers also make a Booker T reference (sorta). Special thanks to Reyna for filling in this episode, shout out to MK2 for the song “Drive Away” at the beginning of the episode, and Evan King for the official theme of KIN, “Alpha Channels”. Rate, comment and subscribe on Apple Podcasts, and spread the word peeps! 1:11 – Intro section with Anthony and Vince 28:01 – SVCC section with Vince and Reyna

April 21st-23rd, 2017, two women took to the road in a Toyota Corolla with a mission: to do as much badass stuff as possible at Silicon Valley Comic Con in San Jose, California. They saw the likes of John Cusack and Buzz Aldrin, learned about NASA and SETI, interviewed professional cosplayers Wasteland Exports, Abby Darkstar, and Kit Quinn, laughed at the tales of Robert Englund's villainous exploits, revisted the skies with Gina Torres, and creepily fangirled over Nichelle Nichols from a safe distance. We were those two women. Boost your Con Karma by listening to this episode of The Ladies of Nerditude.

This is our recording of the Silicon Valley Comic Con 2017 costume contest and awards presentation in San Jose, California. Our complete coverage of Silicon Valley Comic Con 2017 can be seen on AnimeCons TV.

This is our recording of the Silicon Valley Comic Con 2017 costume contest and awards presentation in San Jose, California. Our complete coverage of Silicon Valley Comic Con 2017 can be seen on AnimeCons TV.

SNN is back and just in time for the weekend! This week Pete and Sarah are joined by Orie Enav and he's telling us and YOU all about DragonFruit. A new dating app designed for Geeks to meet other fellow Geeks. After that Orie hangs out and the gang discusses the Game of Thrones trailer, the most recent episode of The Walking Dead and The People vs OJ Simpson. Then they wrap things up with some quick thoughts on Batman v Superman, the release of Daredevil, season 2 and Pete talks a little about SNN and The GWW covering Silicon Valley Comic Con in San Jose. So much geekyness, because its so SCENE N NERD!