Podcasts about E26

Somewhere in Shinjuku... two homosexual Americans in Japan defy state of emergency orders to meet and to wonder before the supreme artlessness of COVID-19 and Anno Hideaki's 2016 masterwork, SHIN GODZILLA. Tortured civilians, atomic breath, the crush of the proletariat, helpless governments, silence in Shibuya Scramble, layers between people, the contemporary condition: who will know tragedy? Follow Ryan on Twitter: twitter.com/tokyohomo And follow I'm So Popular on Twitter too: twitter.com/imsopopularpod impopular.me (S2.E26)

This week's show features a panel discussion between authors Adrian Wells and Hyeon Chang Kim as they discuss their articles "Improving the Effectiveness of Psychological Interventions for Depression and Anxiety in Cardiac Rehabilitation PATHWAY—A Single-Blind, Parallel, Randomized, Controlled Trial of Group Metacognitive Therapy" and "Associations of Ideal Cardiovascular Health and Its Change During Young Adulthood With Premature Cardiovascular Events: A Nationwide Cohort Study." Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. We're your co-hosts. I'm Dr. Carolyn Lam, Associate Editor from the National Heart Center and Duke National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, also your co-host. And Associate Editor, Director of the Pauley Heart Center, VCU Health in Richmond, Virginia. Dr. Carolyn Lam: Greg, we're starting off the month with double features, and these are just so interesting. The first paper talks about psychological interventions for depression and anxiety in cardiac rehabilitation. And the next talks about ideal cardiovascular health and its change during young adulthood and how that relates to premature cardiovascular events. Cool, huh? Dr. Greg Hundley: Absolutely. Well, Carolyn. How about we grab a cup of coffee and start discussing some of the other articles in the issue? And I could go first. Carolyn, the first article that I've got is from Mrs. Elizabeth Jordan from Ohio State University Wexner Medical Center. And it really pertains to cardiomyopathies. And remember, Carolyn, classically, we categorize hypertrophic, dilated, and arrhythmogenic right ventricular cardiomyopathy. And each has a signature genetic theme. Hypertrophic cardiomyopathy and ARVC are largely understood as genetic diseases of sarcomere or desmosome proteins. But in contrast, there are over 250 genes spanning more than 10 gene ontologies that have been implicated in dilated cardiomyopathy. And therefore, it really represents a very complex and diverse genetic architecture. So to clarify this, a systematic curation of evidence to establish the relationship of genes with dilated cardiomyopathy was conducted by an international panel with clinical and scientific expertise in dilated cardiomyopathy genetics. And they evaluated evidence supporting monogenic relationships of genes with idiopathic dilated cardiomyopathy. Dr. Carolyn Lam: Oh, wow. That sounds like a lot of work. And what did they find, Greg? Dr. Greg Hundley: Right, Carolyn. So in the curation of 51 genes, 19 had high evidence. 12 are definitive strong, and seven moderate. And notably, these 19 genes only explain the minority of cases, leaving the remainder of dilated cardiomyopathy genetic architecture really incompletely addressed. And clinical genetic testing panels include most high evidence genes. However also, the panel noted that genes lacking robust evidence are very commonly observed clinically. Dr. Greg Hundley: So Carolyn, the take home message from this international panel is that while dilated cardiomyopathy genetic testing panels include an average of about 60 genes, when curating published evidence for dilated cardiomyopathy, only 19 have really emerged as high levels of evidence. And then in this study, 51 genes were evaluated. And the 19 genes appraised as high evidence were recommended to be routinely used in the genetic evaluation of dilated cardiomyopathy. And one more point. Rare variants from genes without moderate, strong, or definitive evidence should not be used in clinical practice to predict dilated cardiomyopathy risk most importantly when also you're screening at risk family members. Dr. Carolyn Lam: Wow. Very nice. Stunning numbers. Well, my paper is identifying a novel therapeutic target in pulmonary arterial hypertension. Do you want to know what that is? Dr. Greg Hundley: Ah, yes, Carolyn. Very interesting. So what is it? Dr. Carolyn Lam: It's switch-independent 3A. Which is an epigenetic modifier, which is drastically down-regulated in pulmonary arterial hypertension patients and rodent models of pulmonary arterial hypertension. And strongly associated with decreased bone morphogenic protein receptor type two, or BMPR2 expression. So this switch-independent 3A overexpression up-regulated BMPR2 expression by modulating critical epigenetic pathways and decreasing a specific transcription factor binding to the BMPR2 promoter in pulmonary vascular smooth muscle cells. Furthermore, aerosolized lung-targeted gene transfer of adeno-associated virus zero type one and containing switch-independent 3A reversed and prevented pulmonary arterial hypertension phenotype in preclinical animal models. So this beautiful study, from Dr. Hadri from Icahn School of Medicine at Mount Sinai in New York and colleagues, really suggests that switch-independent 3A can be a clinically relevant molecule for the treatment of pulmonary arterial hypertension. Dr. Greg Hundley: Wow, Carolyn. Really nice. Very intricate science for the study of pulmonary hypertension. Well, my next paper actually comes to us from Dr. Joe Hill and colleagues at UT Southwestern Medical Center. And Carolyn, as we know, cardiac hypertrophy is an independent risk factor for heart failure. Of course, the leading cause of morbidity and mortality globally. And the calcineurin NFAT, or nuclear factor of activated T-cells pathway, and the MAP kinase ERK, or extra cellular signal regulated kinase pathway, contributes to the pathogenesis of cardiac hypertrophy as an interdependent network of signaling cascades. However, Carolyn, how these pathways interact really remains unclear. And so Dr. Hill and colleagues engineered a cardiomyocyte-specific ETS2, a member of the E26 transformation specific sequence or ETS domain family knockout mouse, and investigated the role of ETS2 in cardiac hypertrophy. Primary cardiomyocytes were also used to evaluate ETS2 function in cell growth. Dr. Carolyn Lam: Wow. Okay. So what were the results, Greg? Dr. Greg Hundley: Right, Carolyn. Three main findings. First, ETS2 is activated by ERK1/2, or extracellular signal-regulated kinase 1/2, in both hypertrophied murine hearts and in human dilated cardiomyopathy. Second, ETS2 is required for both pressure overload, and calcineurin induced cardiac hypertrophy responses involving signaling cascades distinct from, but interdependent with ERK1/2 signaling. And third, this group discovered that ETS2 synergizes with NFAT to transactivate RCAN1-4, an established downstream target of NFAT, or nuclear factor of activated T-cells. And they identified an MIR-223 as a novel transcriptional target of NFAT ETS2 in cardiomyocytes. Dr. Carolyn Lam: Wow. Wow. That sounds like a lot of detailed work. Could you tell us what the clinical implications are, Greg? Dr. Greg Hundley: You bet, Carolyn. So in aggregate, these findings unveil a previously unrecognized molecular interaction between two conical hypertrophic signaling pathways, MAP kinase-driven hypertrophy, and calcineurin driven hypertrophy. And therefore, as pathological cardiac hypertrophy is an established risk factor for heart failure development, this unveiling of novel signaling mechanisms really is of potential clinical relevance. Dr. Carolyn Lam: Thanks, Greg. Well, let's round up with what else there is in this week's issue. There's a Frontiers paper by Dr. Chris Granger. And it's a big call to action to the cardiology community, to incorporate SGLT2 inhibitors and GLP-1 receptor agonists for cardiovascular and kidney disease risk reduction. There's a Joint Opinion piece from the American Heart Association, World Heart Federation, American College of Cardiology, and European Society of Cardiology on, “The Tobacco Endgame: Eradicating a Worsening Epidemic,” by Dr. Elkind. Dr. Greg Hundley: Oh great, Carolyn. Well, I've got an On My Mind piece from Professor Bhatt. And it's entitled, “Does SGLT1 inhibition Add Benefit to SGLT2 Inhibition in Type 2 Diabetes Mellitus?” And next, Dr. Viskin has an ECG Challenge entitled, “Long QT Syndrome and Torsade de Pointes Ultimately Treated With Quinidine, The Concept of Pseudo Torsade de Pointes.” And then finally, there's a Letter to the Editor by Dr. Lu regarding the article, “Association of Body Mass Index and Age with Morbidity and Mortality in Patients Hospitalized with COVID-19, Results from the American Heart Association COVID-19 Cardiovascular Disease Registry.” Well, Carolyn, I can't wait to get on to this double feature. Dr. Carolyn Lam: Me too. Let's go. Dr. Greg Hundley: Welcome, listeners, to our feature discussion today. And again, we're going to create today a forum, because we have two very interesting papers to present during this timeframe. Our first is going to come to us from Dr. Adrian Wells from University of Manchester. And our second paper will come to us from Dr. Hyeon Chang Kim from Yonsei University. I want to welcome you both, gentlemen. And Adrian, I would like to start with you. Tell us a little bit about the background related to your study. And then what was the hypothesis that you wanted to address? Dr. Adrian Wells: Okay, well thank you for inviting me to take part in this podcast. Following cardiac events, around one in three individuals will develop significant anxiety and depression symptoms. And we know that anxiety and depression can have an impact on prognosis, quality of life, future outcomes. Psychological treatment isn't routinely offered in cardiac rehabilitation for anxiety and depression, despite the fact that we identified that many of our patients felt that they would benefit from a psychological intervention to address these issues. And they felt that their needs were not really being met. So our primary question was, can we improve psychological outcomes in patients with cardiovascular disease? Dr. Greg Hundley: Very nice. And Adrian, what was your study population? And also, what was your study design? Dr. Adrian Wells: So we selected patients who entered cardiac rehabilitation in the UK. So these are patients with acute coronary syndrome, revascularization, stable heart failure, heart transplantation, and so on. And so, a wide group of individuals. We recruited 332 patients, all of whom had had anxiety and depression scores of eight or more. So these were people showing mild to severe levels of psychological distress. We conducted a two arm single blind randomized controlled trial, with 332 patients who were randomly allocated to one of these two conditions. And we assessed anxiety and depression symptoms before treatment at four months and at 12 months. Dr. Greg Hundley: Describe a little bit some of the specifics of your intervention. And then what did you find? Dr. Adrian Wells: We use relatively recent new treatment called metacognitive therapy. And this was delivered in a group format over six sessions. And we trained cardiac rehabilitation staff, nurse consultants, physiotherapists, in the delivery of this intervention. Metacognitive therapy works on helping patients discover unhelpful patterns of thinking, such as worrying and ruminating ,and excessive threat monitoring. And to reduce those patterns of thinking that contribute to anxiety, depression, and poor adaptation following stressful life experiences. Dr. Greg Hundley: And what did you find? Dr. Adrian Wells: Well, what we found was that the addition of metacognitive therapy to treatment to usual cardiac rehabilitation, significantly improved outcomes at four months and 12 months. What was striking about this was that our effect sizes were modest and moderate to large. They seem to be larger than those obtained in other studies or psychological treatments. And of note, the treatment seemed to impact well on both anxiety and depression symptoms. Whereas other types of intervention evaluated in the past have tended to treat the depression, but not so much the anxiety. Dr. Greg Hundley: Very good. So it sounds like a group-based intervention. And I'm assuming maybe participants interacted not only with your staff, but with one another. How would you put your results really in the context with other research that's going on in this space? Dr. Adrian Wells: Well, there have been a number of studies in the past that have looked at individual and group-based treatments, and patient preference for different types of intervention. I think this is the first study to use a clear manualized intervention that's based on the psychological theory of mechanisms that contribute to the maintenance of psychological problems. Obviously, this tended to use more prescriptive interventions like anxiety management, stress management, taking techniques from a range of different sources. So I think there's a difference of conceptual basis to this kind of intervention. And it's something that is highly manualized and structured, and in fact can be delivered by a range of different healthcare professionals. Dr. Greg Hundley: Very nice. And also during cardiovascular rehab. Correct? Dr. Adrian Wells: Absolutely, yeah. During cardiac rehab. One interesting finding... And we were a little concerned that this might adversely affect attendance at cardiac rehab. But we found that the treatment was well tolerated, and it didn't have any negative impact on attendance at these other sessions. Dr. Greg Hundley: Excellent. Well, congratulations on this new finding. Well, listeners, we're next going to turn to Dr. Hyeon Chang Kim from Yonsei University in Korea. And Yong-Chan, could you describe for us also the background related to your study, and the hypothesis that your research wanted to test? Dr. Hyeon Chang Kim: Thank you for inviting me to this wonderful discussion. South Korea is among the countries with the lowest cardiovascular mortality in the world. And the rate is even decreasing. However, cardiovascular risk factor is worsening. Especially in younger generation in Korea. So these young people may not have a very high cardiovascular risk, but I wanted to know the potential impact of worsening cardiovascular risk profile in this younger Korean generation. And furthermore, I wanted to know how much we can lead youth cardiovascular risk by improving their cardiovascular health profile. Dr. Greg Hundley: Very nice. And so tell us about your study design and what was the study population, related to your study? Dr. Hyeon Chang Kim: My study is basically based on the national health checkup program and national health insurance claim database. In Korea, adults over the age of 20 and employed workers of all ages are required to take general health checkup every two years. The participation rate is between 70 and 80%. So we identified three and a half million adults, age 20 to 39 years, who complete the health checkup. And cardiovascular health scores was calculated as the number of ideal cardiovascular health component, which include non-smoking, moderate physical activity three times a week, body mass index below 2030, normal blood pressure, normal cholesterol and normal fasting glucose. So the score can range from zero to six. And higher score meaning better cardiovascular health. Our outcomes were myocardial infarction, stroke, heart failure, and cardiovascular deaths in about 16 years. In addition, we also evaluate the risk of cardiovascular disease. According to two year change in how the vascular health score using repeated health checkup data. Dr. Greg Hundley: Very nice. So evaluating a set of behavioral patterns and risk factors in younger individuals, and then predicting what their longer term adverse cardiovascular outcomes would be. So what did you find? Dr. Hyeon Chang Kim: So even in this relatively low risk population, better cardiovascular health score was associated with significantly lower cardiovascular risk. About 20% reduction per one point higher score. And more importantly, people with improving cardiovascular score over two years showed leading toward cardiovascular risk. Even if their baseline cardiovascular health score was very low. Dr. Greg Hundley: Really unique findings. Tell us about the impact of your results relative to other studies published in this space. And was this also.... This was unique, because it's an Asian population, Dr. Hyeon Chang Kim: Asian population. And we are among the very low risk population. And even in this low risk population, cardiovascular health score was... Fear can be a good predictor of cardiovascular risk. And compared to many Western countries, we have very low cardiovascular risk. And our population was younger than most other studies. So we can provide some evidence that even in the higher risk population, they can do much better, based on our study. Another important thing, we can check the impact of a changing cardiovascular score, even in the younger generation. Dr. Greg Hundley: Very good. And just as a frame of reference for our listeners. Give us some characteristics, if you wouldn't mind, on what really constitutes practically a low risk score, versus what would constitute a high risk score Dr. Hyeon Chang Kim: In this younger Korean population, their cigarette smoking, and their obesity, and physical inactivity are the most common causes of worsening cardiovascular profile. And the behavioral risk factor also can attack the blood glucose and cholesterol blood pressure. So in this younger generation, they're keeping the good behavior. Past behavior is very important and it's beneficial in the very long-term. Dr. Greg Hundley: Very nice, well listeners. We're going to turn to our experts here. Two very interesting studies. And ask them both, what do they think is the next study that needs to be performed in their respective areas of research? So Yong-Chan, we'll start with you. Since we just discussed your paper. What do you think is the next study to be performed really in this sphere of research. Dr. Hyeon Chang Kim: Korea is a relatively low cardiovascular risk, has a very small size, and no racial diversity. But even in this country, disparity and inequality in cardiovascular health is becoming an important issue. So I want to identify subcultural relatively poor cardiovascular health among younger population. And also I want to find ways to improve their cardiovascular score. The conventional approaches, such as education and mass campaign, are less effective oppose this younger adults have a poor socioeconomic status. So, we may need to develop newer target-specific strategies to improve their cardiovascular health. Dr. Greg Hundley: Good. And Dr. Wells, our agent will turn next to you. What do you see is the next area of investigation or research study that needs to be performed in your sphere of interests? Dr. Adrian Wells: Well, I think the next step is to look at rollout of this intervention. Is that feasible, and how acceptable is this to cardiac services? In fact, the National Institute of Health Research have just awarded us some funding to examine feasibility and barriers to implementation in the healthcare system. In addition to that, we're beginning to examine the effects of metacognitive therapy with other health conditions, such as cancer in children and adolescents. Dr. Greg Hundley: Nice. Well listeners, we have had just a wonderful discussion today from both Dr. Adrian Wells from University of Manchester. Who brought to us combining a group-mediated, psychological stress-reducing, anxiety-reducing, intervention to the cardiac rehab sphere. And how impactful that was in reducing both anxiety, and overall depressive symptoms. And then also exciting research from Dr. Hyeon Chang Kim from South Korea. Identifying for us that in Asian population, as well as what we know in other races, those individuals in their twenties to thirties with favorable lifestyle habits, have reduced cardiovascular risk much later in life. Dr. Greg Hundley: Well, on behalf of both Carolyn and myself, we want to wish you a great week. And we'll catch you next week on the run. Dr. Greg Hundley: This program is copyright of the American Heart Association, 2021. The opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors, or of the American Heart Association. For more, visit ahajournals.org.  

Episode 26 of Season 4 is the high point of the year as far as I am concerned, it aired at 7 pm on 1 July 2021.  E26 marks the halfway mark of the year and the joyous news of our ex-president's impending incarceration.  It is also the only show so far to clock in at exactly 3 hours (and 15 seconds) and causing the most perfect switch over between me and the going 'back to the studio'. switchover.  We kicked off with Megadeth and their Rust in Peace classic 'Hanger 18'.  It made sense to stay with the trash heavyweights of the world and we followed with Metallica and 'Creeping Death'.  Next up The Raven Age off their album Darkness Will Rise and this led to a brief discussion of a slight glimmer of hope for SA as Jacob Zuma goes to jail for 15 months for contempt.  We celebrated with Prison Bound by Social Distortion and some optimism in the form of Bon Jovi's 'Keep The Faith'.  There were plenty of big names, we heard from Van Halen, ACDC, W.A.S.P.,  Scorpions, Iron Maiden, and Judas Priest.  The highlight for me, other than all the Zuma jibes, was Skid Row with a track off  United World Rebellion- Chapter One called  'This is Killing Me'.  It is an incredibly good song made all the more poignant by the sad passing of Johnny Solinger, the vocalist on the track earlier this week.  Largely ignored, these last two Skid Row albums shine, RIP Johnny.  We checked out a band I have just discovered this week, Seven Thorns out of Denmark, and their track 'Black Fortress'.  Check out the guitar work about 3 minutes in.  We also got a dose of what would happen if Marilyn Manson replaced Till Lindemann in Rammstein by listening to his vocals on Emigrate's second album Silent So Long.  New stuff from Buckcherry, SA stuff from The Burning and Prime Circle, Punk from Sham 69 and The Jam, and oldies from Python Lee Jackson with 'In a Broken Dream'.  There were lots of dedications to listeners and as I said a huge celebration about Zuma's impending incarceration.  I let The Boss, Bruce Springsteen, have the final word for Zuma with When You're Alone.  It may well be the most perfect radio show I have ever done :-).   Artists featured:  Megadeth, Metallica, The Raven Age, Social Distortion, Van Halen, Cinderella, Python Lee Jackson, W.A.S.P., ACDC, The Burning, We Are Harlot, Bon Jovi, Prime Circle, Oasis, Clutch, Thin Lizzy Emigrate, Seven Thorns, Children of Bodom, Skid Row, Scorpions, Tom Petty, Buckcherry, Danko Jones, Dirty Honey, Iron Maiden, Judas Priest, Hollywood, Vampires, Sham 69, The Jam, Type O Negative, Avenged Sevenfold, Nickelback, Papa Roach, Airbourne, Bruce Springsteen

This episode was recorded on May 19th and 23rd, 2021. — Discussed (part 1): Our initial positions and experiences with the show; whether or not Will Smith is participating in minstrelsy; Cosby’s “Poundcake” diatribe; the Cosby Show, but with hip hop; black shows at the time; hood representation; Living Single; charisma; early 90s sitcoms v. late 90s sitcoms; Family Matters; who’s laughing at who?; final thesis. — Episodes watched: Pilot (S1.E1); Mistaken Identity (S1.E6); The Ethnic Tip (S1.E17); 72 Hours (S1.E23); Winner Takes Off (S3.E15); Six Degrees of Graduation (S3.E24); Blood is Thicker Than Mud (S4.E8); Poppa’s Gotta Brand New Excuse (S4.E24); The Philadelphia Story (S4.E26); Viva Lost Wages (S6.E8) — Discussed (part 2): A full 160; 72 Hours; Mistaken Identity; the story of a misfit; Blood is Thicker Than Mud; the importance of Carlton’s character; what does it mean to be a black man?; Poppa’s Gotta Brand New Excuse; Will Smith’s background; The Philadelphia Story; intended age demographics for The Fresh Prince of Bel-Air; high school level racial dialogue; black people and the entertainment industry; Paul Mooney (R.I.P.); art’s subjectivity vs. sports’ objectivity; “Doing something great is overrated.”; typecasting; and more! — Email us your thoughts, questions, and suggestions at bostonnj@racetraderpodcast.com. Discuss the show with the #racetraderpodcast hashtag on Twitter and everywhere else. Please don’t forget to rate, review and listen on Apple Podcasts, Stitcher or wherever you get your podcasts. --- Send in a voice message: https://anchor.fm/racetraderpodcast/message

Welcome to E26 which finds me whispering the introduction to this fabulous podcast in the box room and trying not to wake a sleeping toddler. my guest today is Megan Clifton. Megan is an F23 director (so we've organised a few events together), a musician, performer and immersive theatre company director and we talk about all these things, and some magic too, in this wonderful conversation. she's just bursting with the fire of creative energy and beware this might just make your device burst into flames!!!Find Megan;https://www.meganclifton.com/https://www.wizardsagainstlizards.com/https://picturesofgwen.com/Find Jamie;Twitter: @JimthdiamondTheme tune by Tom Baker & Daisy Eris Cmapbell

(00:00) Grab your milk & cookies, sit back & enjoy E26 (1:51) best #26 in pro sports discussion (5:27) Mailbag features listeners’ feedback from E24 (7:22) discussion on confidence/ego in sports TV (9:45) After The Pod tackles the subject of “fake live” playbacks in sports TV production (13:06) the boys explain the theme of the episode (14:55) Steve tells an entertaining story involving former NHL goaltender & current broadcaster John Garrett at the old Cap Center in Landover, Maryland (18:12) Paul recounts a humorous NHL on TSN segment involving former NHL goalie & broadcaster Glenn Healy (22:50) Steve details a story about former NHL head coach & broadcaster Harry Neale involving Hockey Hall of Famer Gordie Howe (26:25) Paul chronicles a awkward moment involving himself & Pierre McGuire on their first road trip together at TSN (34:30) Steve tells a priceless story involving former NHL goalie, broadcaster & executive John Davidson’s very first game at Madison Square Garden in New York City (38:45) Conquest Hockey’s Q&A segment spotlights the difference between NHL regular season & Stanley Cup Playoffs broadcasts (45:24) Inside the Truck social media promotion (45:55) as we conclude Season One, special thanks to some of our devoted listeners & brand partners (SummerSkates, Conquest Hockey)

Thank you for Listening Please Share In Season 6 E26 of The Fix Sports Podcast, Joseph shines his HBCU Spotlight on the Florida A&M University Golf team for their appearance in the Tallahassee Regionals, Joseph also shines his light on the HBCU football players who signed as non-drafted free agents with NFL and Canadian football teams. May is Black Women's Celebration Month for the Freedom Train Network. In honor of BWC month, Joseph is highlighting Kelsey Koelzer. Kelsey is th [...]

One of the more awaited episodes of the week is the Thursday show because Alex Calleja makes his way to GTWM and he and Mo are ready to take your stories about love, life, sex -- and we find a way to have a hearty laugh about them. It's E26 and we have two Manila based callers lined up to share some sex related issues. Caller #1 is Bam who is 32yrs old from Manila. Recently, Bam wife asked if they can have a threesome with another guy involved. Bam didn't know how to react to the request so he is looking for some insight on what to do regarding this situation. Caller #2 is Elle who is 22yrs old from Manila. Elle says she has an addiction to watch porn and jumping on Reddit so she can find guys who will jack off to her video stream. The guys arent too convinced that Elle is exactly who she says she is. Powered by Anchor.fm , we will see you on another episode of GTWM tomorrow. Thanks for the download and please support the podcast by donating as little as $0.99 cents via Anchor at: anchor.fm/djmotwister --- Send in a voice message: https://anchor.fm/djmotwister/message Support this podcast: https://anchor.fm/djmotwister/support

咖啡灌腸是通過肛門注射咖啡以清潔直腸和大腸的灌腸相關程序。沒有醫學和科學證據支持咖啡灌腸的任何積極健康聲明。該過程可導致敗血症，嚴重的電解質紊亂，結腸炎，直腸結腸炎，內部灼熱，直腸穿孔，甚至腦膿腫或心力衰竭。 咖啡灌腸的歷史 History 雖然直腸清潔的想法可以追溯到古埃及人，但咖啡作為灌腸相關物質的概念並不新鮮。它於1917年構思出來。1920年，德國科學家研究了咖啡因對膽管和小腸的影響。 Max Gerson提出咖啡灌腸對胃腸道有積極作用。 Gerson說咖啡灌腸具有積極的排毒作用，有助於恢復患者的健康。他聲稱，與鹽水灌腸不同，灌腸中的咖啡通過小腸的平滑肌進入肝臟。他說，這可以刺激自主神經系統，就像咖啡因口服時一樣，激活肝臟中膽汁的釋放，清除更多的胃腸道並排出比正常灌腸更多的毒素。他經常告訴他的病人，“咖啡灌腸不是為了腸道的功能，而是為了刺激肝臟。” 結腸清潔的實踐經歷了20世紀90年代的復興，此時，咖啡灌腸被用作替代癌症治療。 效用和風險 一些替代醫學的支持者聲稱咖啡灌腸通過“解毒”腫瘤的代謝產物而具有快速解毒作用。但是，目前沒有醫學科學證據支持咖啡灌腸的任何解毒或抗癌作用。咖啡灌腸可能引起嚴重的副作用（一些常見於其他類型的灌腸），包括感染，敗血症，嚴重的電解質紊亂，結腸炎，直腸結腸炎，沙門氏菌，腦膿腫和心力衰竭。 如果咖啡灌入太快或太熱 ，它可能導致內部燒傷或直腸穿孔。 每兩小時給藥一次，由於嚴重的電解質紊亂，低鈉血症，脫水和胸膜和心包積液，咖啡灌腸已經顯示與兩例死亡病例有關。美國食品和藥物管理局（FDA）已經裁定提供咖啡灌腸者必須警告使用者有關咖啡灌腸死亡的風險。 參考資料： Teekachunhatean S, Tosri N, Sangdee C, et al. Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers. Hum Exp Toxicol. 2012 Jul;31(7):643-51. Jones LE, Norris WE. Rectal burn induced by hot coffee enema. Endoscopy. 2010;42 Suppl 2:E26. Sashiyama H, Hamahata Y, Matsuo K, et al. Rectal burn caused by hot-water coffee enema. Gastrointest Endosc. 2008 Nov;68(5):1008; Ernst, E. "Colonic irrigation and the theory of autointoxication: a triumph of ignorance over science". Journal of Clinical Gastroenterology. 1997 Jun; 24 (4): 196–198. Lee C, Song S, Jeon J, et al. "Coffee enema induced acute colitis". The Korean Journal of Gastroenterology. 2008; 52 (4): 251–254. Shils ME, Hermann MG (April 1982). "Unproved dietary claims in the treatment of patients with cancer". Bull N y Acad Med. 1982 Apr; 58 (3): 323. Cassileth B. "Gerson regimen". Oncology 2010 Feb;24 (2): 201. Margolin, K.; Green, M. "Polymicrobial enteric septicemia from coffee enemas". The Western Journal of Medicine. 1984;140 (3): 460. Eisele J, Reay D. "Deaths related to coffee enemas". JAMA: The Journal of the American Medical Association. 1980; 244 (14): 1608–1609. Keum B, Jeen YT, Park SC, et al. "Proctocolitis Caused by Coffee Enemas". The American Journal of Gastroenterology. 2010; 105 (1): 229–230. Sashiyama H, Hamahata, Y, Matsuo K, et al.”Rectal burn caused by hot-water coffee enema". Gastrointestinal Endoscopy. 2008; 68 (5): 1008–1009. Paran H, Butnaru G, Neufeld D, et al. "Enema-induced perforation of the rectum in chronically constipated patients". Diseases of the Colon and Rectum. 1999; 42 (12): 1609–1612. Teekachunhatean S, Tosri N, Rojanasthien N, et al. Pharmacokinetics of Caffeine following a Single Administration of Coffee Enema versus Oral Coffee Consumption in Healthy Male Subjects. ISRN Pharmacol. 2013;2013:147238. 咖啡灌腸的風險： 1. 電解質不平衡 2. 腸粘膜燙傷 3. 腸穿孔 4. 腸炎、感染

1M podcast E26 by SilasBeats

Arnoux (are-know) Goran grew up in hell with 2 deaf crack addicts, who left him destroyed physically, emotionally, mentally, and spiritually. As an adult, he found himself repeating his childhood patterns of starvation, loneliness and depression, until he invented the 7 Steps To Reprogramming Yourself…the first ever way to erase repeating negative thoughts and old emotions permanently. He completely changed his life, and has successfully taught it to thousands of people of all ages, who have had incredible results in their finances, relationships, and health. It’s been studied by the University of California Irvine, showing 100% of the participants erased their negative emotions and could do it on their own after the training. Arnoux has appeared on TV, Radio and been a guest speaker for Universities and Fortune 500 Companies.

Halo!Welcome to E26, we are keeping the lessons coming, this Episode is a 2-fer! Uncle Mike will teach Tony D & DJ MOE how to say some of our favorite sports in Croatian. You'll also learn along with the boys, how to count from 11 to 20!This Episodes Super Slatko Report will cover a traditional Croatian Sword Dance. DJ MOE will break it down for you and where to see it for yourself.Laugh and Learn with us!Enjoy!

Ben Herrington is a professional route setter and likely Washington’s most prolific boulderer. We talked about why Ben performs best as a “weekend warrior”, his three go-to training sessions, mistakes he sees other boulderers making, climbing vs. skateboarding, his history with drug abuse and addiction, the path to sobriety, some of his most meaningful FAs, and V15 potential in Washington.  Support on Patreon:patreon.com/thenuggetclimbing  Show Notes:  http://thenuggetclimbing.com/episodes/ben-herrington  Nuggets:  1:56 – Feeling aimless without work, missing purpose, and the subtle curse of being a full-time climber  4:09 – Skatingboarding vs. climbing: mastering, achieving, and style  7:37 – Ben’s three climbing categories (strength, technique, and try hard) and which one holds him back  9:31 – Practicing “try hard” with a three-try limit  10:31 – Skateboard culture, proving your right to be there, and “success days” vs. “training days”  12:30 – Why Ben feels like he performs best as a weekend warrior  13:38 – Ben’s three go-to indoor sessions  14:52 – The Sharma philosophy: flash or limit  15:42 – Ben’s “Strength Day”  17:24 – Why Ben prefers climbing other people’s hard boulders, wanting to be good at every style, the ego beatdown of changing styles, and The Red vs. Smith  21:21 – Why hard climbing isn’t type-1 fun, and why the variety in climbing appealed to Ben so much after skating  22:40 – Ben’s strength/power bouldering session length, gym climbing vs. outdoor climbing in terms of weight lifting, and gym climbing because it’s fun  25:54 – “Medium Day”, “Endurance Day”, and the benefits of down climbing for fitness  27:44 – Transfering sport climbing fitness back to bouldering, and climbing ‘The Reckoning’  29:11 – St. George bouldering vs. sport climbing, and expanding your horizons to have more 5-star lines to do  31:09 – Ben’s interest in trad/mixed climbing, and the routes that pull at him most  33:03 – The fun vs. suffering spectrum, and “everybody knows what it takes, they just have to be willing to do it.”  34:51 – What motivated Ben when he was younger vs. now  37:04 – Ben’s oppositional strength training routine,  training front levers once every two weeks, and the evolution of Ben’s core training  39:48 – How Ben can tell if a climber has good core strength, and the importance of core strength for hard climbing  40:38 – Training Front Levers, plank variations, and the feeling of being wrecked  42:37 – Lack of training consistency due to COVID, the approach of summer, and missing the climbing gym  44:55 – Ben’s weekly climbing schedule, and always taking Friday off  45:26 – 14 years sober, addiction to pain pills, and how Ben got started in climbing  49:19 – Obsessive-compulsive behavior, losing friends and his dad to drugs, moving to WA to get sober, and early bouldering in Leavenworth  55:27 – The obsessed bug  57:04 – Exploring for new routes, and bolting ‘Imagine’  1:03:41 – Cleaning and climbing ‘Imagine’ during quarantine  1:06:31 – John Lennon’s ‘Imagine’, the setting, the rock, and everything you’d want in a route  1:07:53 – The story behind ‘Inception’ (Ben’s favorite FA)  1:11:00 – Ben’s early progression in climbing, the “spurge and plateau”, and filling out the repertoire  1:12:54 – Some of the best hard boulders in WA, Newhalem bouldering, and endangered moss  1:15:58 – V15 potential in WA  1:17:45 – Ben’s ideal boulder condition for NW granite, giving credit to “the cracking” of a sequence or boulder problem, and the challenge of grading FAs  1:19:33 – What holds back climbers in the gym  1:21:38 – What holds back climbers when projecting outdoors  1:23:26 – How Ben decides whether to keep trying a climb, optimism vs. pessimism, and ‘Singularity’  1:26:52 – Gratitude  1:27:30 – Missing the gym  1:28:25 – Ben’s plans for the summer, and chasing conditions  1:32:24 – Ben’s Instagram, his recent Squamish video (that you should all watch—see show notes), and not knowing where to post climbing content  1:34:46 – Ben’s latest skate trick project, and influencing kids at the skate park  

E26 – The Role of Learning and Development: Interview With Lorna Gamman, Head of L&D for Krispy Kreme UK With over 15 years of L&D experience, Lorna Gamman comes with a wealth of experiences including her current role as head of L&D for Krispy Kreme. We ask, What is the role of learning and development? What is L&D strategy? Where does L&D strategy fall down? What does L&D need to do to overcome this? We also look at where Lorna’s career is headed to next and her role in supporting SME’s with her experiences. You Can Read the Transcript of Our Interview Below: Nathan Simmonds: Welcome to Sticky Interviews. I’m Nathan Simmonds, senior leadership coach and trainer for MBM, Making Business Matter, the home of Sticky Learning. We are the provider of leadership development and soft skills training to the grocery and manufacturing industry. The idea of these interviews is to share great ideas, great concepts, and great ways these skills are being used to help you be the best version of you in the work that you do. Welcome to the show. Nathan Simmonds: Welcome to another Sticky Interview with me, Nathan Simmonds, senior leadership coach and trainer for MBM, Making Business Matter, the home of Sticky Learning. Idea with these interviews is help you be the best version of you. I feel like I rushed that, but that’s because I’m really enthused, energized, and kind of really, really enjoying this conversation that’s been happening before this recording and what we’ve had before. Today, I have the privilege of speaking to Lorna Gamman, the head of L&D from Krispy Kreme Doughnuts, which in itself is prestigious enough for such a large company that’s been around for nearly 100 years now. Lorna will correct me on that in just a minute. She has a phenomenal history with just over 15 years of L&D skills, hands-on practical skills, and is through this current situation, transitioning from this environment to a new world, potentially HR consultancy, L&D consultancy. Taking all those wonderful experiences that she’s got from these incredible people and these incredible spaces, and helping to package that, and giving it to new people that need that support in a different way. So it’s an exciting venture that I’ve been having a conversation, an exciting new venture ahead of Lorna as she moves into this space. Welcome to Sticky Interviews, Lorna. Thank you for being here. Lorna Gamman: No worries. Thank you for having me. Nathan Simmonds: Look, I want to dive in because I want people to hear as much of what’s going on in your head. I love asking you questions because, and I say this with absolute love and respect, you’ve got a lot to say on these things. You bring an enthusiasm and energy with it that is infectious and I want you to share that with people. For me, the first question is always why do you do what you do? Lorna Gamman: Yeah. I think for me, I love people and enabling people to be the best version of themselves. I love the selfish part of knowing that I’ve had even a teeny, little part to play in that because I think gives you the best feeling. That might be a simple conversation that changes the way th

E26 – The Role of Learning and Development: Interview With Lorna Gamman, Head of L&D for Krispy Kreme UK With over 15 years of L&D experience, Lorna Gamman comes with a wealth of experiences including her current role as head of L&D for Krispy Kreme. We ask, What is the role of learning and development?...

As Y rejoins the group with a new friend, Balnay, the Obsidian Souls proceed deeper into the volcanic chambers. Will freeform singing sooth the angry elemental forces at play? Not when forces are working against them to bring back the Dragon Empire by destabilizing the elements. Thank you for bearing with us as we adaptContinue reading "Edge of Desolation: E26"

H.A.P.P.Y Squad is full of loss. They have lost their quary and they have lost a companion. A fitting tribute and an unexpected memorial party may not allow the Squad to get their emotional bearings before they have to finally make their way back to the encampment. Thank you for bearing with us during theContinue reading "Adventures in Gebrecan: E26"

Choosing the best candidate to fill a management position in your company is one of the most crucial and challenging things. Working with the right talent can put you and the employee on the path to success, while hiring the wrong person can unavoidably hurt your business. Don’t miss Ralph Peterson’s tips on how to master the art of filling leadership roles in this OBT newest episode.

This week the entire complement of the Shuttle Pod crew look back on how Star Trek looks forward. Many fans are drawn to Trek due to its positive outlook on the future of humanity and the way in which the show handles the exploration of the human condition. In these tumultuous times, we could all use a bit of positive escapism, and so Brian, Matt, Kayla, and Jared offer up some of their favorite examples of aspiration in Trek (plus some just plain feel-good eps that you’re sure to enjoy). Come on a new kind of journey with us this week, as we dive into the philosophical and the inspirational, after some stirring words from John Kennedy, some of our on-screen heroes, and the Great Bird of the Galaxy himself. Looking for some Star Trek to make you feel warm and fuzzy inside? Try these episodes and movies: The Original Series TOS S1 E02 “The Corbomite Maneuver” TOS S1 E19 “Arena” TOS S1 E23 “A Taste of Armageddon” TOS S1 E26 “Devil in the Dark” TOS S1 E27 “Errand of Mercy” TOS S2 E21 “By Any Other Name” TOS S1 E28 “City on the Edge of Forever” The Next Generation TNG S2 E12 “The Royale” TNG S4 E13 “Devil’s Due” TNG S5 E02 “Darmok” TNG S5 E26 & E27 “Time’s Arrow” Parts 1 and 2 TNG S7 E25 & E26 “All Good Things…” Parts 1 & 2 Deep Space Nine DS9 S1 E01 “Emissary” DS9 S4 E08 “Little Green Men” Voyager VOY S6 E12 “Blink of an Eye” Enterprise ENT S2 E02 “Carbon Creek” ENT S4 E21 “Terra Prime” Movies “Star Trek IV: The Voyage Home” “Star Trek: First Contact” …and so many more! Tell us your favorites in the comments!

This week the entire complement of the Shuttle Pod crew look back on how Star Trek looks forward. Many fans are drawn to Trek due to its positive outlook on the future of humanity and the way in which the show handles the exploration of the human condition. In these tumultuous times, we could all use a bit of positive escapism, and so Brian, Matt, Kayla, and Jared offer up some of their favorite examples of aspiration in Trek (plus some just plain feel-good eps that you’re sure to enjoy). Come on a new kind of journey with us this week, as we dive into the philosophical and the inspirational, after some stirring words from John Kennedy, some of our on-screen heroes, and the Great Bird of the Galaxy himself. Looking for some Star Trek to make you feel warm and fuzzy inside? Try these episodes and movies: The Original Series TOS S1 E02 “The Corbomite Maneuver” TOS S1 E19 “Arena” TOS S1 E23 “A Taste of Armageddon” TOS S1 E26 “Devil in the Dark” TOS S1 E27 “Errand of Mercy” TOS S2 E21 “By Any Other Name” TOS S1 E28 “City on the Edge of Forever” The Next Generation TNG S2 E12 “The Royale” TNG S4 E13 “Devil’s Due” TNG S5 E02 “Darmok” TNG S5 E26 & E27 “Time’s Arrow” Parts 1 and 2 TNG S7 E25 & E26 “All Good Things…” Parts 1 & 2 Deep Space Nine DS9 S1 E01 “Emissary” DS9 S4 E08 “Little Green Men” Voyager VOY S6 E12 “Blink of an Eye” Enterprise ENT S2 E02 “Carbon Creek” ENT S4 E21 “Terra Prime” Movies “Star Trek IV: The Voyage Home” “Star Trek: First Contact” …and so many more! Tell us your favorites in the comments!

A8M #797 - Lo mejor de lo mejor Recibo mucho feedback y preguntas sobre muchos de los productos de los que hablo en el podcast, hoy hago una selección de los mejores de ellos con las mejores ofertas del BlackFriday de los productos de los que más me habéis preguntado. Perfumia.es: Código APSSMAC1 - 1 Frasco de regalo por cada perfume comprado. Perfumia en Amazón: Código APPSMAC1 - 2€ de descuento en cada frasco. Altavoces Sonos: Sonos Beam - 339€ en Macnificos Sonos One - 164€ en Macnificos Redes Mesh Orbi RBK20 - 199€ Orbi RBK23 - 259€ Philips Hue Kit inicio 3 bombillas, interruptor y puente - 84€ Kit inicio 3 bombillas E26 - 96€ en Macnificos Netatmo Termostato Netatmo - 119,99€ Estación meteorológica Netatmo - 109,99€

This week John and Luke are talking about a system to get more out of you conference investment. https://www.virtualleadershipacademy.com/blog/E26

On this episode, E26 of #thepozcat, I bring you a master of the art of LinkedIN, tactics, tactics and more tactics. He is a digital marketing Vet who has fully capitalized on LI to grow is own business and teach others with his blueprint course.Joe Apfelbaum is the CEO of Ajax Union, a B2B digital marketing agency based in Brooklyn, NY. Joe is a business strategist, marketing expert and certified Google trainer. Joe is the Author of his new book High Energy Secrets, How he lost 95 pounds and has more energy than ever. When he is not Mojovating entrepreneurs at events and on social media he chills in Brooklyn with his Wife and 5 kids, which is his greatest accomplishment.If he is not all over your feed, by design, then you must not be doing something right. Also, he is known to bust out a freestyle rap (stay tuned till the end) I have been connected to Joe for a while and we have some close mutual friends and colleagues. We have had a couple of great chats and I knew I had to have him on to spit some knowledge. Joe is a content machine, a constant source of energy and drive and I am thrilled to have him on today!I appreciate you listening, commenting, sharing and subscribing!ThanksAdam 

Are you excited about the return of Captain Picard?!?!  We are!!  Do you have a friend/spouse/pet who might need a little refresher course on who this Picard guy is and what the heck is going on with these Borg people?  Well, we put together a list of episodes to watch while you're waiting.  Think of it as a little Star Trek Picard primer based on what we know so far about the show. You have a few months to get ready but if you don’t want to marathon all of TNG & Voyager, this watch list should help. :) First-- the basics. You’ll be introduced to Captain Picard, Data, and the Borg.  - Star Trek TNG - S1. E13. Datalore - Star Trek TNG - S2. E9. Measure of a Man.  - Star Trek TNG - S3. E26. & S4. E1. Best of Both Worlds (parts 1 & 2) - Star Trek TNG - S4. E2. Family - Star Trek TNG - S4. E3. Brothers - Star Trek TNG - S5. E23. I Borg - Star Trek TNG - S5. E25. The Inner Light - Star Trek TNG - S6. E15. Tapestry  - Star Trek TNG - S6. E26. & S7. E1. Descent (parts 1 & 2) - Star Trek TNG- S7. E25 & 26. All Good Things (parts 1 & 2) - Star Trek: Generations  - Star Trek: First Contact Then you’ll want to know who Seven on Nine is!  - Star Trek VOY - S3. E26. & S4. E1. Scorpion (parts 1 & 2) - Star Trek VOY - S4. E2. The Gift - Star Trek VOY - S6. E16. Collective  - Star Trek VOY - S7. E18 Human Error  - Star Trek VOY - S7. E 25 & 26. Endgame (pats 1 & 2) Then wrap up the Picard & Data story - Star Trek: Nemesis Finally, I think the 24th-century events in this film will matter a lot-- specifically what happens to the planet Romulus.  - Star Trek (2009)

E26 features Jim Ryan, great conversation about happiness and how it can improve your life and business life. At end of the podcast, Jim explains what his favorite purchase was, hint, don’t die with your music still in you.3 of the takeaways from this conversation are:1- it is my life, I am responsible2- You have to be grateful 3- Take a chance, step out of your comfort zone.http://JimRyanTalks.com (631) 754-7636 Motivational Speaker Author of "Simple Happiness" and "Aha Moments 1 & 2" - available at JimRyanTalks.com and Amazon.com Watch Jim at http://www.jimryantalks.com/media_videos.html Learn more by watching https://www.youtube.com/watch?v=M4pt_rsGdLs 

E26 features Jim Ryan, great conversation about happiness and how it can improve your life and business life. At end of the podcast, Jim explains what his favorite purchase was, hint, don’t die with your music still in you.3 of the takeaways from this conversation are:1- it is my life, I am responsible2- You have to be grateful 3- Take a chance, step out of your comfort zone.http://JimRyanTalks.com (631) 754-7636 Motivational Speaker Author of "Simple Happiness" and "Aha Moments 1 & 2" - available at JimRyanTalks.com and Amazon.com Watch Jim at http://www.jimryantalks.com/media_videos.html Learn more by watching https://www.youtube.com/watch?v=M4pt_rsGdLs 

It's our wildcard episode! We're doing "Q-Who?", giving Sarge her first taste of The Borg, and a Q episode that isn't garbage. Topics include  include whether Wesley is a child soldier, Picard's wrecklessness, and Starfleet PTSD. Join us!