Podcasts about Sharfstein

Send us a textIn part two of our insightful conversation, Dr. Susan Sharfstein builds on our previous discussion of developability assessment to explore how AI is revolutionizing protein manufacturability predictions.As a Professor of Nanoscale Science and Engineering at the University of Albany, she shares groundbreaking insights from her collaboration with DeepSeq AI, demonstrating how artificial intelligence is transforming our ability to assess and predict protein manufacturability early in development.Key Takeaways:Discover how AI tools are enhancing traditional developability assessments by predicting protein expression and stability before entering the labLearn why integration of experimental validation with AI predictions is crucial for successful manufacturability assessment, and how industry partnerships are making this possible at unprecedented scaleUnderstand how the synergy between AI, DNA synthesis capabilities, and robotics is creating a "positive spiral" that will accelerate protein manufacturing innovationWhether you're involved in candidate selection, process development, or curious about AI's impact on developability assessment, this episode offers valuable insights into the future of protein manufacturing. Plus, Dr. Sharfstein shares invaluable career advice for emerging biotech scientists.Join us to explore how AI is reshaping developability assessment and learn why this field continues to offer life-changing possibilities for patients worldwide.Connect with Susan Sharfstein:LinkedIn: https://www.linkedin.com/in/susan-sharfstein-b7552111/College of Nanotechnology, Science, and Engineering, University at Albany: https://www.albany.edu/cnseNext Steps:Wondering how to develop cell and gene therapies with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentDevelop biologics better, faster, at a fraction of the cost with our 1:1 Strategy Call. Book your call at https://stan.store/SmartBiotech/p/book-a-11-call-with-me-j4vhuo6t

Send us a textIn this eye-opening episode, we dive deep into the critical yet often overlooked world of protein manufacturability with Dr. Susan Sharfstein, Professor of Nanoscale Science and Engineering at the University of Albany. As part of the broader developability assessment process, manufacturability evaluation helps determine whether a therapeutic candidate can be successfully produced at commercial scale.Drawing from her extensive experience in bioprocessing and cell culture technology, Dr. Sharfstein reveals why seemingly promising protein candidates can fail during manufacturing—and how to spot these issues early.Key Takeaways:Discover why efficacy isn't enough: Learn how to evaluate protein candidates beyond clinical performance to ensure manufacturing successMaster early-stage assessment: Understand the critical parameters that can make or break successful scale-up, from cell line selection to protein foldingFuture-proof your development: Gain insights into how AI is transforming protein manufacturability assessment and what this means for process developmentWhether you're selecting protein candidates or optimizing your bioprocess, this episode offers invaluable guidance for making smarter decisions earlier in development. Join us to learn how to bridge the gap between discovery and manufacturing success.Listen now to transform how you approach protein manufacturability and save valuable time and resources in your development journey.Connect with Susan Sharfstein:LinkedIn: https://www.linkedin.com/in/susan-sharfstein-b7552111/College of Nanotechnology, Science, and Engineering, University at Albany: https://www.albany.edu/cnseNext Steps:Wondering how to develop cell and gene therapies with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentDevelop biologics better, faster, at a fraction of the cost with our 1:1 Strategy Call. Book your call at https://stan.store/SmartBiotech/p/book-a-11-call-with-me-j4vhuo6t

אַ כּ‫תיבֿה וחתימה טובֿה! Highlights: Avrom Novershtern (Israel) Professor Emeritus of Yiddish Literature, Hebrew University, Jerusalem. We reached him by phone on Friday, Sept. 27, 2024. Eli Sharfstein (Israel) writer and poet. We reached him by phone in Greece, where he was stranded due to cancelations of flights to Israel, on Tuesday, Oct. 1, 2024. Rabbi Itzik-Boruch Teitelbaum (Monroe, NY), known as Der Pshiskher Rov. We reached him by phone at his home in Monroe on Tuesday, Oct. 1, 2024. Greetings on behalf of the American Association of Jewish Holocaust Survivors and Descendants of Greater Boston, featuring members Tania Lefman (Treasurer), Mary Ehrlich, Rosalie Reszelbach and Miriam Modricamin. Greeting from Dovid Braun, co-host. Recorded Oct. 2, 2024, by phone. Greetings from Eli Dovek ז״ל, late proprietor of our sponsor Israel Bookshop, Brookline, MA. Greeting from Sholem Beinfeld, co-host. Recorded Sept. 18, 2024, by phone. Greeting from Lillian (Leye) Leavitt, co-host. Recorded Sept. 25, 2024, by phone. Greetings on behalf of the League for Yiddish / די ייִדיש-ליגע by Gitl Schaechter-Viswanath, Board Chair. Recorded Sept. 18, 2024. Greetings on behalf of the Hebrew Actors Foundation and CYCO Yiddish Book Center by Hy Wolfe. Recorded via Zoom Sept. 18, 2024. Music: (Partial List) Cantor Joseph Shapiro: B'Rosh Hashona Malavsky Family: Kevah Kures Sholom Katz: Zochreinu L'Chayim Intro instrumental music: DEM HELFANDS TANTS, an instrumental track from the CD Jeff Warschauer: The Singing Waltz Air date: October 2, 2024

This week we observe Yom HaAtzmaut (Israel Independence Day) talking with Mike Burstyn, Miriam Trinh, Eli Sharfstein and Avremi Zaks. Links mentioned in this episode: Beit HaLochem (Los Angeles): https://www.israeliwoundedveterans.org The Zweiflers TV series starring Mke Burstyn, home page League for Yiddish: https://leagueforyiddish.org Afn Shvel Issue #400-401 at League for Yiddish Yiddish Forward (Forverts): https://forward.com/yiddish/ Forverts Article on Interview with Tzili Venkert, grandmother of hostage Omar Venkert Yiddish Branzhe: https://yiddishbranzhe.com Kan Yiddish (כאן יידיש) archive (Avremi Zaks's Yiddish radio show) Music/recordings: Dovid Esheth: Yerusholayim Shtot fun Gold Moshe Stern: A Gezang Tzu Yisroel Barry Sisters: Vi Ahin Zol Ikh Geyn Yakov Sandler: Tel Aviv Richard Inger: Israel Leo Fuld: Vi Ahin Zol Ikh Geyn Intro instrumental music: DEM HELFANDS TANTS, an instrumental track from the CD Jeff Warschauer: The Singing Waltz Air date: May 8, 2024

Joshua Sharfstein is distinguished professor of the practice in health policy and management at the Johns Hopkins Bloomberg School of Public Health. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.M. Sharfstein and L.O. Gostin. The Public Good on the Docket — The Supreme Court's Evolving Approach to Public Health. N Engl J Med 2024;390:1637-1639.

On today's episode we hear a rebroadcast of the a 2024 Social Sciences Forum (SSF) lecture  delivered by Dr. Joshua Sharfstein. Dr. Joshua Sharfstein is Vice Dean for Public Health Practice and Community Engagement at the Johns Hopkins Bloomberg School of Public Health.  Dr. Sharfstein is also the Director of the Bloomberg American Health Initiative, and a Professor of the Practice in Health Policy and Management. Check out the following links for more information on UMBC, CS3, and our host: The UMBC Center for the Social Sciences Scholarship The University of Maryland, Baltimore County Ian G. Anson, Ph.D. Retrieving the Social Sciences is a production of the UMBC Center for Social Science Scholarship.  Our podcast host is Dr. Ian Anson, our director is Dr. Christine Mallinson, our associate director is Dr. Felipe Filomeno, and our production intern is Jean Kim.   Our theme music was composed and recorded by D'Juan Moreland.  Special thanks to Amy Barnes and Myriam Ralston for production assistance.  Make sure to follow us on LinkedIn, Twitter, Facebook, Instagram, and YouTube, where you can find full video recordings of recent UMBC events.

To continue our podcast series on the topic of Building a Family, we hear from Mrs. Shifra Sharfstein as she teaches us the second half of her 2-part series on the Ma'amer P'ru Urvu, where she explains why the neshama wants us to invite it into this world. ⁠Click here⁠ for the text of the Maamer. --- Support this podcast: https://podcasters.spotify.com/pod/show/mikvah/support

To continue our podcast series on the topic of Building a Family, we hear from Mrs. Shifra Sharfstein as she teaches us the first half of her 2-part series on the Ma'amer P'ru Urvu, where she explains why the neshama wants us to invite it into this world. Click here for the text of the Maamer. --- Support this podcast: https://podcasters.spotify.com/pod/show/mikvah/support

In the last episode of 2023, Lindsay Smith Rogers talks with co-hosts Dr. Josh Sharfstein and Stephanie Desmon about 2023. This year saw a rise in non-COVID topics, including Supreme Court cases, malaria, RSV, antitrans health legislation, climate emergencies, artificial intelligence, and more. They also talk about what topics they're thinking about for 2024. Learn more about another one of our projects, the Expert Insights newsletter: http://publichealth.jhu.edu/subscribe

Dr. Ashish Jha, former White House COVID-19 response coordinator under President Biden, helped the country move out of the acute phase of the pandemic—and learned a lot in the process. Dr. Jha talks with Dr. Josh Sharfstein about what surprised and disappointed him during his federal experience, what it was like to feel responsible for the health of 300+ million people, and why he's concerned about respiratory virus season this year, and every year. Plus: listen to the end to hear a little history about Dr. Jha and Dr. Sharfstein.

‫מיר טרויערן נאָך די מער ווי 1,400 מענטשן שוידערלעך אומגעבראַכט פֿון דער טעראָר-גרופּע כאַמאַס אין ישׂראל דעם 7טן אַקטאָבער 2023. מיר זאָרגן זיך זייער וועגן די פֿאַרוווּנדעטע, זאָלן זיי אַלע האָבן אַ רפֿואה־שלמה, ווי אויך וועגן די פֿאַרכאַפּטע, זאָלן זיי אַלע צוריקקומען אַהיים בשלום.‬‬ ‫ ‫הערט אינטערוויוען מיט ישׂראלים וועגן דער טעראַר-אַטאַקע און דער איצטיקער מלחמה אין ישׂראל:‬ אלי שאַרפֿשטיין Eli Sharfstein (Spoke by WhatsApp Thursday, Oct. 26, 2023) בעלאַ בריקס-קלײַן Bella Bryks-Klein (Spoke by phone Monday, Oct. 30, 2023) וויקי שיפֿריס Viki Shifris (Spoke on Zoom Tuesday, Oct. 31, 2023) מרים טרין Miriam Trinh (Spoke on Zoom Monday, Oct. 30, 2023) ‫ We mourn the more than 1,400 people horribly murdered by the terror group Hamas in Israel on October 7, 2023. We are deeply concerned for the wounded -- may they all be restored to health, and the captives -- may they all get home safely. Hear interviews with Israelis about the terror attack and the current war in Israel. Music: Intro instrumental music: DEM HELFANDS TANTS, an instrumental track from the CD Jeff Warschauer: The Singing Waltz Air date: November 1, 2023

For many people, the idea of politics in healthcare conjures up hyperpartisanship, where power and party loyalty trump public interest. But Joshua Sharfstein, MD is passionate about politics and health care because to him, these are opportunities to bring together wide-ranging expertise and navigate seemingly irreconcilable interests to implement changes that change the lives of millions. Dr. Sharfstein has led a career reflective of this passion. He has served as the Secretary of the Maryland Department of Health, the Principal Deputy Commissioner of the US Food and Drug Administration, and the Commissioner of Health for Baltimore City, and is currently Vice Dean for Public Health Practice and Community Engagement at the Johns Hopkins Bloomberg School of Public Health. Over the course of our conversation, Dr. Sharfstein discusses why public health matters, how he handles partisanship in politics, and his career highs and lows and lessons learned on effective crisis management.In this episode we discuss:2:16 - How medicine and politics ended up being a twin focus of Dr. Sharfstein's career5:07 - The milestones of Dr. Sharfstein's career in healthcare leadership8:39 - Why healthcare arouses such intense partisan political feelings13:51 - How public health's messaging and communication must change in light of current advancements in information technology18:42 - The formative public health crises that Dr. Sharfstein has dealt with throughout his career26:33 - Ideas for strengthening the US's weak public health system29:28 - How COVID-19 revealed the flaws of our public health system33:55 - Dr. Sharfstein's advice for clinicians who are interested in working in public health38:00 - Sustaining drive and momentum amid bureaucracy in public health41:56 - A sampling of the unsafe products that Dr. Sharfstein has successfully gotten taken off of the market Dr. Sharfstein is the author of The Public Health Crisis Survival Guide: Leadership and Management in Trying Times.You can follow Dr. Joshua Sharfstein on Twitter @DrJoshS.Visit our website www.TheDoctorsArt.com where you can find transcripts of all episodes.If you enjoyed this episode, please subscribe, rate, and review our show, available for free on Spotify, Apple Podcasts, or wherever you get your podcasts. If you know of a doctor, patient, or anyone working in health care who would love to explore meaning in medicine with us on the show, feel free to leave a suggestion in the comments or send an email to info@thedoctorsart.com.Copyright The Doctor's Art Podcast 2023

Dr. Joshua M. Sharfstein is a professor of the practice of health policy and management at the Bloomberg School of Public Health at Johns Hopkins. According to Wikipedia, he is an “ardent supporter of vaccines as an essential part of public health” and was appointed by President Obama as principal deputy commissioner of the Food and Drug Administration from 2009 to 2011.   Learn more at Joshua Sharfstein | Johns Hopkins (jhu.edu) Connect with Dr. Sharfstein on Twitter @drJoshS Follow our podcast on Facebook @TheOptimalLifePodcast If you enjoyed this episode, you might also like: Ep. 260 - Wayne Rohde :: Vaccine Injuries and the Flawed Vaccine Court Ep. 242 - HEATED Abortion Debate with Thomas Connick and Ashlie Sletvold  

Jill Sharfstein interviews her friend Nancy Fisher about the aftermath of the 1998 fire,  Central's embrace of Avery Fisher Hall, and Nancy's enduring connection to Central even while hospitalized. 

“What Matters” is a collaborative initiative by New York Jewish institutions enabling individuals to have conversations about — and document — end-of-life preferences … and engage Jewish values along the way. Rabbi Nicole Auerbach, Dir. of Congregational Engagement at Central Synagogue in New York, and Howard Sharfstein, Honorary President at Central, describe the program and […] The post “What Matters”: Rabbi Nicole Auerbach and Howard Sharfstein of Central Synagogue appeared first on Plaza Jewish Community Chapel.

Dr. Johnathon Ehsani is an expert in traffic safety at the Johns Hopkins Bloomberg School of Public Health. He speaks with Dr. Sharfstein about the safety of autonomous vehicles today and what might be possible in the future. He also shares what he thinks of the potential benefits of this technology.

In this bonus episode, Johns Hopkins Professor Thomas Burke joins Dr. Sharfstein to talk about  the risk to residents following the train derailment and toxic release of chemicals in East Palestine, Ohio— the knowns, the unknowns, and where to go from here. Dr. Burke is a former environmental official for the state of New Jersey and a former science adviser of the Environmental Protection Agency

Howard Sklamberg, a former deputy commissioner of the U.S. Food and Drug Administration, talks to Dr. Sharfstein about legislation passed at the end of 2022 to improve the safety of cosmetics. On the agenda for discussion: inspections, manufacturing standards, recalls, and the answer to the trivia question of whether a combination of antiperspirant and deodorant is considered a cosmetic or a drug.

Dr. Roger Mitchell, the former chief medical examiner of the District of Columbia, and current chief of pathology at Howard University speaks with Dr. Sharfstein about how deaths in custody are classified. Dr. Mitchell has observed that when it comes to understanding the reasons for these deaths, the usual rules of autopsies and death investigations don't always seem to apply. He's leading the charge to understand more about what's happening. 

Our guest is Judge David Tatel, who recently took senior status on the U.S. court of appeals for the DC circuit after joining the court in 1994. He was appointed to fill the seat created by the appointment of Justice Ruth Bader Ginsburg to the Supreme Court. Judge Tatel speaks with Dr. Sharfstein about West Virginia v. EPA, in which the Supreme Court announced a major new doctrine for judging actions by health agencies to protect the public.

In the last episode of Season 6, Lindsay Smith Rogers talks with co-hosts Dr. Josh Sharfstein and Stephanie Desmon about 2022: how it started, what happened, and how it's going now. They reflect on the changing COVID response, listener feedback, standout episodes, notable guests, looking ahead to topics for 2023 and more. This episode was recorded in person as a video and can be viewed on the @johnshopkinssph YouTube channel. Please vote for the podcast in the Signal Listener's Choice Awards! Info here: https://bit.ly/PHPodVoting 

In this episode, we are joined by Sarah Sharfstein, Vice President of Category Development and Strategy at Aspen Dental, to discuss incremental growth through aligners and the flexibility of Motto aligners to consumers.This podcast is sponsored by Aspen Dental.

Dr. Mauda Monger is a lifelong resident of Jackson, Mississippi. She is also a community advocate and public health professional. She talks with Dr. Sharfstein about how the water crisis is the most visible sign of a profound decline in her hometown and perhaps could help bring about a brighter future. Dr. Monger runs an initiative for young women of color in Jackson called the S-H-E Project. Learn more  

Dr. Carolyn Sufrin joins the podcast to talk with Dr. Sharfstein about the implication of overturning Roe vs Wade for a special population—people who are incarcerated. Dr. Sufrin is an obstetrician/gynecologist and a researcher on reproductive health at Johns Hopkins. 

Howard and Jill Sharfstein speak about their marriage, and their 40 years as congregants of Central Synagogue. Together they reflect on how Central became increasingly more important through Howard's illness and their growing involvement after his recovery, including Howard's position, in 2006, as Chair of the Central Board of trustees.

On this episode of Built on Regen, a community voices series of the Planetary Regeneration podcast, host Gregory Landua chats with Howard Sharfstein, co-founder and Board President of Kulshan Carbon Trust: a non-profit that promotes and enables regenerative natural climate solutions. Tune in to learn about carbon trusts, and what it means to take a multistakeholder approach to regenerative agriculture. Learn more at kulshuncarbontrust.org. Find the transcript for this episode here: https://tinyurl.com/047-kulshanct

In April, Dr. Josh Sharfstein appeared on the Washington Journal segment of C-SPAN to talk about the podcast and answer questions from callers live on TV. Many of the questions stemmed from misinformation that's proliferated online, but all COVID questions deserve answers. In this bonus episode, we share some of those questions and Dr. Sharfstein's responses—live and unscripted.

This is a special edition Contagious Conversations podcast in conjunction with Public Health On Call, a podcast from the Johns Hopkins Bloomberg School of Public Health. This special edition features a discussion between CDC Foundation President and CEO Judy Monroe, MD, and Joshua Sharfstein, MD, vice dean for public health practice and community engagement at Johns Hopkins Bloomberg School of Public Health. Dr. Sharfstein and Dr. Monroe discuss the importance of state public health and the future of public health in our nation.   For a full episode transcript, visit cdcfoundation.org/conversations.   Key Takeaways: [1:10] Dr. Monroe provides information about her background. [2:15] Dr. Monroe was asked by Indiana Gov. Eric Holcomb to co-chair a commission looking at the public health system in the state of Indiana and making recommendations for future policies. [4:46] Dr. Monroe discusses how this public health commission is structured in Indiana and what they are tasked with. [7:00] Dr. Sharfstein asks about the state of the public health workforce in Indiana. [9:48] Dr. Monroe explains that we need to get to people in ways that they will be receptive to information about public health. [11:40] Dr. Sharfstein asks Dr. Monroe if anything has surprised her with this public health commission process. [14:04] How do we assess the challenge of the future of public health in America? [14:21] Dr. Monroe discusses the Lights, Camera, Action National Summit Series. [18: 40] One challenge with public health is that it is often invisible. [19:22] Dr. Monroe asks Dr. Sharfstein about the role of public health schools in this landscape. [20:12] Dr. Monroe says it is incumbent on all of us to give our best in this moment and to work together.     Mentioned in This Episode: CDC Foundation Johns Hopkins University Bloomberg School of Public Health Contagious Conversations Public Health On Call

Early in the pandemic, the National Institutes of Health launched a response against the new virus that has expanded to include basic and clinical research, and research into vaccines and treatments. Dr. Emily Erbelding, director of the Division of Microbiology and Infectious Diseases, talks with Dr. Josh Sharfstein about NIH's role in supporting the scientific community, what treatments are currently gaining attention and scrutiny, and how the race to produce a vaccine needs multiple contenders.

Louisiana was hit early and hard by COVID-19 but, over the past three months, the statewide response has strengthened. Now, Louisiana health officials are using the lessons they learned from the outbreak's early days to ensure that they are prepared to weather the surge in cases throughout the American South. Dr. Alexander Billioux, assistant secretary of health for the Louisiana Department of Health's Office of Public Health, joins Dr. Josh Sharfstein to discuss the strategies that have worked, the underlying realities the pandemic has exposed, and the vast amount of work that's still left to be done.

Why has the US had a harder time with the virus than Europe? Why does contact tracing seem to be working in some places but not others? Does it make sense to wear face coverings outside? Can COVID-19 be killed in the freezer? Can I get COVID-19 from a pool? What about in an elevator? Dr. Tom Inglesby of the Center for Health Security and Dr. Josh Sharfstein address your questions submitted to publichealthquestion@jhu.edu

COVID-19 has seen unprecedented harassment of state and local health officials. In a bonus episode, Dr. Georges Benjamin, executive director of the American Public Health Association, talks with Dr. Josh Sharfstein about the threats facing public health officials in the pandemic.

Several Latin American countries are seeing a wave of COVID-19 cases and deaths. Dr. Carlos Castillo-Salgado, who has trained hundreds of epidemiologists in Latin America, talks with Dr. Josh Sharfstein about what's going wrong, what's going right, and what needs to change fast on the continent to save lives.

A year ago, the American Academy of Pediatrics released a landmark statement about the impact of racism on child and adolescent health. Dr. Maria Trent, the lead author of this statement, talks with Dr. Josh Sharfstein about the many ways that racism undermines health over a lifetime. Trent also discusses how to give pediatricians, teachers, parents, and caregivers the language and tools they need to address racism's impacts on children's safety and wellbeing.

Early in the US outbreak of COVID-19, New Orleans was struck hard. At one point, the city of about 400,000 people was seeing up to 450 cases diagnosed per day. Today, it has reduced cases 95% from that peak. Dr. Jennifer Avegno, director of the Health Department in New Orleans, said this is due in no small part to New Orleans's history of disaster and the infrastructure and partnerships that were put in place following Hurricane Katrina. Avegno talks with Dr. Josh Sharfstein about how New Orleans pulled out of the tailspin, what the city continues to do to keep cases down, and why protesting is an “essential” activity.

The protests following the homicide of George Floyd reflect serious questions about the legitimacy of the police. Law professor and philosopher Ekow Yankah talks with Dr. Josh Sharfstein about the nature of legitimacy and the longstanding double standard that has led the nation to a moment of reckoning on race. He explains, “We can no longer have an America where white problems are social problems and black problems are policing problems.”

A special episode today as Dr. Josh Sharfstein discusses Albert Camus's The Plague with Dr. Mark Christian Thompson, chair of the English department at Johns Hopkins. The Plague, which was written in 1947, is immediately relevant to our experiences with COVID-19 and so much more. Thompson and Sharfstein discuss the book's relevance to current events including racial and social inequality. (Don't worry: You do not have to have read The Plague before listening to the podcast!)

Until now, the focus of this podcast has been on COVID-19. Today, we are broadening the podcast to cover other urgent public health issues starting with racism, police violence, and the national protests over the homicide of George Floyd. Dr. Josh Sharfstein talks with Baltimore author, artist, and activist Chris Wilson about his experiences both in and out of the prison system, his reflections on “unstacking the deck” against people of color, and the role of art in healing, documenting, and storytelling during galvanizing moments.

What can people do to reduce their risk of contracting COVID-19 during a protest? Do higher-risk patients ever have mild novel coronavirus or do they always get very sick? When is it ok to resume routine medical and dental care? Will people who have had COVID-19 be eligible for a vaccine when it's available? Are gloves necessary like masks?

Dr. Julie Gerberding was director of the CDC during the 2003 SARS outbreak and lessons learned from that response are now informing her work overseeing some 65,000 employees around the world as executive vice president of Merck. Gerberding talks with Dr. Josh Sharfstein about the US's response, how Merck is keeping things moving, why emerging infectious diseases may be a new normal, and how the pandemic is contributing to the threat of antimicrobial resistance.

Like many countries, Canada recognized the pandemic in stages, but unlike some, Canada used advanced warning to their benefit with swift mandates. Dr. Brian Goldman, host of CBC's “The Dose” podcast, talks with Dr. Josh Sharfstein about how although Canada's response has differed from the US's, the country faces many of the same challenges with testing, outbreaks in vulnerable populations, and a patchwork approach of mandates across provinces.

The use of investigational drugs during a public health crisis is not new. In 2014, Dr. Linda Mobula had experience administering an untested drug during the Ebola response in West Africa. Mobula talks to Dr. Josh Sharfstein about how the technical framework that came out of that process could have been used to provide guidance for investigational drugs in COVID-19, and how political figures created a global push for hydroxychloroquine.

Responses to COVID-19 such as school closures and shelter-at-home orders may inadvertently raise the risks of child sexual abuse. Dr. Elizabeth Letourneau, director of the Moore Center for the Prevention of Child Sexual Abuse, talks with Dr. Josh Sharfstein about risks, prevention strategies, and a new online resource for parents, caregivers, and people at risk of offending. Warning: This episode covers difficult topics directly.

Dr. Panagis Galiatsatos spends 12-16 hour days attending to COVID-19 patients in the ICU at Johns Hopkins Hospital. When he's not at the hospital, he's on duty in the community working with faith based organizations, schools, and housing units to help leaders protect their community members from getting sick. Galiatsatos talks with Dr. Josh Sharfstein about these dual roles of being on both the last and first lines of defense—caring for patients in the ICU and helping to prevent them from getting there in the first place.

Dr. Arturo Casadevall—head of the convalescent plasma research project at Johns Hopkins—talks through the WHO's recent statement that there's no evidence of COVID-19 infection leading to short- or long-term immunity. Casadevall and Dr. Josh Sharfstein also discuss how COVID-19 is not like HIV or pneumonia, and what we currently know about new strains of the novel coronavirus.

Schools are scrambling to figure out education during the COVID-19 pandemic. Matt Hornbeck, principal of the top-rated Hampstead Hill Academy—a Pre-k-8 public school in southeast Baltimore city—says instruction is only part of the challenge: technology gaps, trying to reach vulnerable students, and the trauma of a sudden separation from friends and teachers are unprecedented issues to address. Hornbeck talks to Dr. Josh Sharfstein about how Hampstead Hill is trying to take care of its school community, and how they're preparing for the next period of uncertainty.

Homelessness is already a public health emergency in the US. COVID-19 now adds to the unique challenges facing individuals without homes. So how are the homeless and their caregivers responding? Kevin Lindamood and Dr. Adrienne Trustman of Baltimore's Health Care for the Homeless, and Barbara DiPietro of the National Health Care for the Homeless Council talk with Dr. Josh Sharfstein about homelessness amid a pandemic.

What makes this virus different from hundreds of other similar viruses? What happens if parents don't take their children for routine immunizations? Does prone body positioning help ICU patients? Does coronavirus spread best in wet or dry environments? What are randomized control trials and why is everyone talking about them? Is it possible to give someone a tattoo from six feet away? Lauren Sauer, director of Operations with the Johns Hopkins Office of Critical Event Preparedness and Response (CEPAR) and Assistant Professor of Emergency Medicine at Johns Hopkins Medicine, addresses questions submitted to publichealthquestion@jhu.edu

In March, Johns Hopkins Hospital began making its own COVID-19 tests. The lab now has the capacity to run 600 tests per day, but is limited by shortages in the supply of reagents: the chemicals needed to process the tests. Dr. Karen Carroll, director of the Division of Medical Microbiology at Johns Hopkins Hospital talks with Dr. Josh Sharfstein about what it takes to develop a working COVID-19 test, why labs across the US are struggling with shortages, and what needs to happen to fix access to testing.

Since the COVID-19 pandemic began, the opioid epidemic disappeared from headlines but not from reality. Dr. Josh Sharfstein talks to Dr. Yngvild Olsen, the medical director of an addiction treatment program in Baltimore and the Vice President of the American Society of Addiction Medicine, about how her clinic had to pivot to stay open while protecting both patients and staff, how federal regulations have shifted, and what the status of the epidemic is and might be post-COVID-19. Disclosure: Medical school classmates, Dr. Sharfstein and Dr. Olsen are married.