Podcasts about Adenosine

Introduction Dr. Arreaza: Hello, everyone, today we continue with our series about sleep. I invite you to listen to Moira Wilson on Episodes 220 and 221 about the approach of insomnia and CBT-I in adults. Today we will discuss not only what to do, but also why it works. We frequently hear advice like ‘get more sleep,' but we need to dig deeper into the physiology behind it. So, Dr. Kim and Dr. Carlisle are here to briefly explain the physiology of sleep and what we can do to support better sleep. But before we start, let's welcome Dr. Carlisle, who recently matched to our program. He will start his residency soon, and Dr. Kim, who will soon become a PGY2, welcome doctors.  Dr. Carlisle: [Introduce yourself].  Dr. Kim: [Introduce yourself].  Dr. Arreaza: Let's start simple. Why does sleep matter clinically? Why Sleep Matters Dr. Kim: Sleep is one of the most important biological processes we have. It's not passive; it's highly active and tightly regulated. It affects cognition, metabolism, immune function, cardiovascular health, and hormonal balance. When sleep is disrupted, you see downstream effects in almost every organ system. Dr. Carlisle: Yeah, and one thing I always emphasize is that sleep deprivation isn't just about feeling tired. It actually puts you in a physiologic state that's very similar to being intoxicated. There are studies showing that being awake for about 24 hours can impair cognitive performance to a level comparable to being above the legal driving limit for alcohol. Dr. Arreaza: That's actually kind of scary when you think about it.  Dr. Carlisle: It really is. Another way to think about it is sleep deprivation doesn't just make you slower; it actually changes how you make decisions. People become more impulsive and less risky. And in medicine, we see that translates into increased medical errors, decreased attention, and poor decision-making. So, from a clinical standpoint, sleep isn't optional; it's foundational. Dr. Kim: Delay caffeine (but not too late), avoid alcohol, and focus on behavioral strategies (put away your phone 1 hour before bedtime).  Dr. Carlisle: And sleep is the foundation of performance. If sleep is off, everything else is compensating. Dr. Kim: And even beyond cognition, even one night of poor sleep can impair immune function and shift hormones that regulate hunger, which is why people tend to crave more food when they're sleep deprived. Dr. Arreaza: I think it's wise to dispel the myth of the “Russian Sleep Experiment”, have you heard about it? Dr. Carlile-Dr Kim: [reaction] Dr. Arreaza: The “Russian Sleep Experiment” is an internet horror story claiming Soviet scientists kept prisoners awake for several weeks using a gas. They developed extreme paranoia, violence, and self-mutilation. Then, the experiment got out of control, the subjects became unrecognizable, they refused to sleep, continued to deteriorate, and went insane. Even though the story went viral in 2010, it is fictional (reaction), with no real evidence that it really happened. So, it is just a made-up horror story. But there are some real studies about sleep deprivation in humans.  Dr Kim: Yes, the most famous case was Randy Gardner (1964) who stayed awake for 11 days. He developed hallucinations, memory problems, and mood changes. He recovered after sleep (no permanent “madness”). Dr. Carlisle: Sure, but as I mentioned before, even one night without sleep significantly reduces performance and accuracy. Dr. Kim: Another myth we fall into is “catching up on sleep”. It is a myth! Sleep Architecture Dr. Arreaza: Sleeping is a state when you reset your brain and your energy, but what actually happens during sleep? Dr. Carlisle: Sleep cycles between non-REM and REM stages. Non-REM sleep, especially deep, slow-wave sleep, is where physical restoration happens. That's when you get growth hormone release, tissue repair, and metabolic recovery. Dr. Kim: And one of the most fascinating things is what happens in the brain during that deep sleep. The space between brain cells actually expands, which allows cerebrospinal fluid to circulate and clear out metabolic waste. Dr. Carlisle: That's the glymphatic system. And what's interesting is that this clearance is most active during deep sleep (Stage 3, Delta waves). It clears neurotoxins like beta amyloid, which is one reason chronic sleep deprivation is linked to neurodegenerative diseases, such as Alzheimer's disease.  Dr. Arreaza: So, your brain is basically cleaning itself while you sleep. The “glymphatic system” is relatively new. It was described in 2010, and it clears substances like beta-amyloid, which is linked to Alzheimer's disease. Dr. Carlisle: Exactly. Then REM sleep is more focused on brain function. That's where memory consolidation, emotional processing, and learning really happen. Dr. Kim: And REM sleep tends to occur more in the second half of the night. So, when people cut their sleep short, they lose a lot of that REM sleep, which affects mood, focus, and overall cognitive function. What Drives Sleep Dr. Arreaza: So, what actually makes us feel sleepy? Dr. Kim: There are two main processes. The first is the homeostatic drive, where adenosine builds up in the brain the longer you're awake, creating sleep pressure.  Dr. Carlisle: And the second is your circadian rhythm, which is controlled by your brain's internal clock and influenced mainly by light exposure. Dr. Arreaza: So, in summary, one process depends on how long you've been awake, and the other process depends on your body's own timing.  Dr. Carlisle: Exactly. I think of it as pressure and timing. Adenosine builds pressure, and your circadian rhythm determines when that pressure gets released. Dr. Kim: And when those two systems are aligned, sleep happens naturally. When they're out of sync, that's when people start having issues.  Morning Routine Dr. Arreaza: Let's talk about practical tips. The morning seems to be a key element in our sleep. What can we do in the mornings to help us sleep at night? Dr. Carlisle: Morning sunlight, without a doubt. Getting light exposure within the first 30 to 60 minutes of waking helps anchor your circadian rhythm. Dr. Kim: And outdoor light is much stronger than indoor light, even on cloudy days. Dr. Carlisle: The mechanism is that light activates specialized retinal cells that signal your brain's clock. That sets the timing for cortisol release in the morning and melatonin release later at night. Dr. Kim: And it also increases dopamine early in the day, which helps with mood, motivation, and focus. Dr. Carlisle: So, you're not just waking up; you're setting up your entire day's physiology. Caffeine and Hydration Dr. Arreaza: Light exposure; I like the idea. That's why phototherapy works for any kind of depression, not only seasonal depression. What other suggestions can you give us about our morning routine?  Dr. Carlisle: Hydration first thing in the morning helps restore plasma volume and improve alertness since we're mildly dehydrated overnight. Dr. Kim: It is also a good idea to add electrolytes to the water. And caffeine timing is huge. If you drink it right when you wake up, you're interfering with your natural adenosine cycle. Dr. Carlisle: Exactly. Caffeine blocks adenosine receptors, but it doesn't remove adenosine. So later in the day, when caffeine wears off, all that built-up adenosine hits at once, and that's what causes the crash. And that's why some people feel wired but still tired because the underlying sleep pressure is still there, just being masked by the caffeine.  Dr. Arreaza: So, what should people do instead? (I say people because I personally don't drink coffee, and occasionally I drink caffeine) Dr. Kim: People should wait about 60 to 90 minutes before having caffeine.   Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week!  _____________________ References: 1. Williamson AM, Feyer AM. Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication. Occup Environ Med 2000;57(10):649-655. 2. Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342(6156):373-377. 3. Walker MP. Why We Sleep: Unlocking the Power of Sleep and Dreams. Scribner; 2017. 4. McMorris T, Harris RC, Swain J, et al. Effect of creatine supplementation and sleep deprivation on cognitive performance. J Sports Sci. 2006;24(3):305-313. 5. Turner CE, Byblow WD, Gant N. Creatine supplementation enhances corticomotor excitability and cognitive performance during sleep deprivation. J Sleep Res. 2015;24(3):307-315. 6. Gordji-Nejad A, Matusch A, et al. Creatine supplementation and brain energy metabolism during sleep deprivation. Sci Rep. 2024;14:54249. 7.  Wienecke E, Nolden C, et al. Magnesium and sleep quality: systematic review. *Med Res Arch.2021. 8. Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/. Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week!

Contributor: Travis Barlock, MD Educational Pearls:   Caffeine Geography and Types: Caffeine is found throughout the world and has evolved independently in various plants that are not evolutionarily related through direct lineage, but rather demonstrate convergent evolution (i.e. different species evolve the same traits).  These plants use caffeine as an insecticide.  Examples of caffeine sources include coffee, tea, yerba-mate, guaraná, cacao, and yaupon holly. Roughly 85% of Americans are estimated to consume caffeine daily.   Caffeine Pharmacology in Humans:  In humans, caffeine is a nonselective competitive antagonist (blocker) of adenosine receptors (A1 and A2A).  During waking hours, neuronal metabolic activity consumes ATP, and a byproduct of ATP hydrolysis is created: adenosine.  Adenosine proceeds to build a "sleep pressure".  Acting on A1 and A2A adenosine receptors to induce sleep (on A1, it suppresses neuronal "wakefulness" and on A2A it is believed to be an inducer of sleep).  Caffeine, by blocking those receptors, blunts sleep induction and feelings of being tired.  Caffeine has a half-life of around 6 hours, and a quarter life of approximately 12 hours, which is when the caffeine will off-load and adenosine can once again occupy those receptors, potentially causing a "crash".  Thus, for shift-workers, it is important to time caffeine intake roughly 10 hours before target bed time.  Caffeine exerts other effects on the body.  It is methylxanthine similar to theophylline, which works as a bronchodilator (via phosphodiesterase and adenosine pathways). Caffeine has clinical use to promote bronchodilation in pre-term infants.  Caffeine exerts diuretic effects as well (blocking proximal renal tubule reabsorption).  Recent ingestion of caffeine may blunt therapeutic use of adenosine in patients with SVT.  Key Takeaway? Caffeine exerts a wide variety of effects beyond making us feel more awake. It has cardiovascular, pulmonary, and renal implications in its pharmacodynamics.   References    Benarroch EE. Adenosine and its receptors: multiple modulatory functions and potential therapeutic targets for neurologic disease. Neurology. 2008;70(3):231-236. doi:10.1212/01.wnl.0000297939.18236.ec Mitchell DC, Knight CA, Hockenberry J, Teplansky R, Hartman TJ. Beverage caffeine intakes in the U.S. Food Chem Toxicol. 2014;63:136-142. doi:10.1016/j.fct.2013.10.042 Bruschettini M, Brattström P, Russo C, Onland W, Davis PG, Soll R. Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity - Bruschettini, M - 2023 | Cochrane Library. Accessed May 23, 2026. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013873.pub2/full?cookiesEnabled Huang R, O'Donnell AJ, Barboline JJ, Barkman TJ. Convergent evolution of caffeine in plants by co-option of exapted ancestral enzymes. Proc Natl Acad Sci U S A. 2016;113(38):10613-10618. doi:10.1073/pnas.1602575113 Cabalag MS, Taylor DM, Knott JC, Buntine P, Smit D, Meyer A. Recent caffeine ingestion reduces adenosine efficacy in the treatment of paroxysmal supraventricular tachycardia. Acad Emerg Med. 2010;17(1):44-49. doi:10.1111/j.1553-2712.2009.00616.x  Summarized by Dan Orbidan, OMS2 | Edited by Dan Orbidan & Ahmed Abdel-Hafiz, NREMT-P   Donate: https://emergencymedicalminute.org/donate/   Join our mailing list: http://eepurl.com/c9ouHf  

You already know sleep matters. What you don't know is why you keep waking up at 2 AM, why your tracker is probably lying to you, and why the rules you've been following may not be meant for you. Dr. Michael Breus is one of the world's leading sleep doctors - not just a sleep expert, but a clinical psychologist who actually treats patients and pressure-tests every theory in real life. The difference matters. The rule saying you need a pitch-black, 65-degree room with no TV and no partner? He sleeps with two French bulldogs and a big screen on. His point isn't that sleep hygiene doesn't matter. It's that it has to work for your actual life. One thing that might reshape how you think about your body: every human on earth wakes up between 1 and 3 AM. It's biology. Your core body temperature drops to prevent hypothermia, and your body briefly surfaces. Most people roll over and go back to sleep. If you don't, the fix isn't pills - it's understanding what's happening and using tools like 4-7-8 breathing to lower your heart rate below 60 and let sleep return naturally. Your chronotype - lion, bear, wolf, or dolphin - is genetic. It shifts across your lifetime. Forcing a wolf to be a lion doesn't make them a better performer; it makes them worse. The biggest unlock, according to Dr. Breus, isn't more sleep. It's doing the right things at the right time for your specific biology. Dr. Breus has a five-step daily framework he gives every patient. It's specific, it's sequenced, and most people are violating at least three of the steps without knowing it. Dr. Breus's books: Sleep Drink Breathe: Simple Daily Habits for Profound Long-Term Health Energize!: Go from Dragging Ass to Kicking It in 30 Days The Power of When: Discover Your Chronotype and the Best Time to Eat Lunch, Ask for a Raise, Have Sex, Write a Novel, Take Your Meds, and More The Sleep Doctor's Diet Plan: Lose Weight Through Better Sleep Beauty Sleep: Look Younger, Lose Weight, and Feel Great Through Better Sleep Take The Chronotype Quiz! Dr. Breus on Instagram Dr. Breus on LinkedIn In this episode you will: Learn the five-step framework Dr. Breus uses with CEOs, elite athletes, and patients to dramatically improve sleep quality without medication Discover the 4-7-8 breathing technique developed by Dr. Andrew Weil and how it lowers your heart rate to unlock sleep when your mind won't stop Understand chronotype science - whether you're a lion, bear, wolf, or dolphin - and how aligning your schedule to your biology changes everything from performance to sex drive Uncover the truth about sleep trackers, melatonin supplements, and why eight hours is not the universal target you've been sold Master the Napa Latte protocol and non-sleep deep rest (Yoga Nidra) as emergency recovery tools when life disrupts your sleep For more information go to https://lewishowes.com/1930 For more Greatness text PODCAST to +1 (614) 350-3960 Follow The Daily Motivation for essential highlights from The School of Greatness More SOG episodes we think you'll love: Andrew Huberman Dr. Baland Jalal Shawn Stevenson TOPICS chronotype, circadian rhythm, sleep drive, adenosine, 4-7-8 breathing, Yoga Nidra, non-sleep deep rest, Napa Latte protocol, melatonin, chrono longevity, sleep anxiety, Dr. Michael Breus Get more from Lewis! Get my New York Times Bestselling book, Make Money Easy!Get The Greatness Mindset audiobook on SpotifyText Lewis AIYouTubeInstagramWebsiteTiktokFacebookX Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Show notes at pharmacyjoe.com/episode1130 In this episode, I'll discuss the use of an initial 6 mg vs 12 mg dose of adenosine for supraventricular tachycardia.

[Ep63] During this month's episode, we ask six medical questions to five different AI tools. Listen in to find out which questions were a problem. Here's What We Asked02:26 - Q1: What is a normal PR interval on an ECG?03:08 - Q2: What is the medication, Lisinopril?03:51 - Q3: How is Adenosine administered and how does it work on a person's heart?06:14 - Q4: What studies have been done, with adults, relating to adenosine administration methods?09:07 - Q5: If a patient has a crooked smile, a weak grip in their right hand, and no arm drift, what is their LAMS score?12:23 - Q6: When does the American Heart Association recommend giving epinephrine when a deceased patient starts the arrest in a shockable rhythm?Episodes Mentioned in this PodcastEp14 - Adenosine | Do you use the single or double-syringe method?Do you have ideas for future guests or topics on this podcast? Maybe you have some thoughts on how to improve the show? If that sounds like you, take a moment to answer the 3 questions on our anonymous feedback survey!Podcast artwork was made with the awesome resources from CanvaMusic and Sound FX for the show obtained from Pixabay and Pond5Email the show at hfconversations@gmail.comClosed Captioning Resources:Podnews article (for Apple/Android phones and Google Chrome browsers)Microsoft Windows article (live captions for Windows users)Apple article (live captions for Mac users)Disclaimer:The thoughts and opinions expressed in this podcast belong solely to those saying them, and do NOT represent the positions, strategies or opinions of Trinity Health or Mount Carmel Health System. This podcast is intended for educational and entertainment purposes only. Nothing in this podcast establishes a patient care relationship with you, the listener. The host(s) and guests of this show are NOT your healthcare provider and if you need medical attention, seek an appropriate and qualified professional. 

A lot of us aren't just tired—we're worn down. In a world that keeps demanding more attention, more productivity, and more endurance, our nervous systems are struggling to keep up. This episode kicks off our season on wellness by starting at the most basic place recovery happens: sleep.You can also watch the very first Brain Blown Podcast episode on video on our YouTube channel!>> Support the Brain Blown on Patreon>> Have questions, stories, or topics you want us to cover? Email us at info@brainblownpodcast.com.>> Learn more at www.brainblownpodcast.comREFERENCES:Falup‑Pecurariu, C., Diaconu, Ș., Țînț, D., & Falup‑Pecurariu, O. — Neurobiology of Sleep (Review)National Institute of Neurological Disorders and StrokeLee, A. E., Ancoli-Israel, S., Eyler, L. T., Tu, X. M., Palmer, B. W., Irwin, M. R., & Jeste, D. V. — Sleep Disturbances and Inflammatory Biomarkers in Schizophrenia: Focus on Sex DifferencesPocivavsek, A., & Rowland, L. M. — Basic Neuroscience Illuminates Causal Relationship Between Sleep and Memory: Translating to SchizophreniaPeever, J., & Fuller, P. M. — Neuroscience: A Distributed Neural Network Controls REM SleepAulsebrook, A. E., Jones, T. M., Rattenborg, N. C., Roth II, T. C., & Lesku, J. A. — Sleep Ecophysiology: Integrating Neuroscience and EcologySimon, K. C., Nadel, L., & Payne, J. D. — The Functions of Sleep: A Cognitive Neuroscience PerspectiveUrry, E., & Landolt, H.-P. — Adenosine, Caffeine, and Performance: From Cognitive Neuroscience of Sleep to Sleep PharmacogeneticsKay, D. B., & Buysse, D. J. — Hyperarousal and Beyond: New Insights into the Pathophysiology of Insomnia Disorder through Functional Neuroimaging StudiesZielinski, M. R., McKenna, J. T., & McCarle, R. W. — Functions and Mechanisms of SleepMarques, D. R., Gomes, A. A., Caetano, G., & Castelo-Branco, M. — Insomnia Disorder and Brain's Default-Mode Network

Adenosine isn't just a drug — it's a cardiac truth serum. In this episode, we break down how it interrupts SVT circuits, exposes fake ventricular tachycardia, and helps paramedics think instead of memorize. From street-level pharmacology to real case application, learn why that momentary asystole might actually mean you saved a life

Send us a textIntegration of brain metabolism with neural signaling, highlighting how core metabolites regulate energy use and protect neurons.Topics Discussed:Brain energy efficiency: Brains are much more energy-efficient than computers for similar processing, relying on adaptive metabolic strategies evolved under energy scarcity.Metabolism vs. information processing: Core metabolites like glutamate bridge basic cellular energy production and neural signaling.Lactate as a signal: Produced during exercise, lactate diffuses from muscles to brain, modulating neuronal excitability and providing neuroprotection.BHB in ketosis: During fasting or ketogenic diets, beta-hydroxybutyrate displaces glucose as fuel, enhances antioxidant defenses, and activates protective potassium channels in neurons.Adenosine and sleep: Accumulates from ATP breakdown during wakefulness, triggering sleep and locally inhibiting overactive neural networks for energy conservation.Glial cells' role: Astrocytes and oligodendrocytes handle sophisticated metabolism, release signaling molecules like lactate, and modulate synapses, and influence diseases like Alzheimer's.Practical Takeaways:Regular exercise elevates lactate, which signals the brain to adapt metabolism and may enhance neuroprotection against stress.Intermittent fasting or ketogenic diets can induce ketosis with BHB, potentially boosting brain antioxidant defenses and preconditioning against metabolic stress.Prioritizing sleep helps clear adenosine buildup, restoring energy balance and supporting long-term neural health.About the guest: Dr. Luis Felipe Barros, MD, PhD is a Chilean neurobiologist and professor at the Universidad de Valparaíso, where he leads a lab studying brain metabolism from glucose transport to mitochondrial function.Related Episode:M&M 255 | Unlocking Energy: How Nutrition & Drugs Impact Your Mitochondria | Chris Masterjohn*Not medical advice.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Special sale Nov 10 - Dec 1: Lumen is half off ($599 → $299), and MINDMATTER gets another 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, get $100 off for AquaTru Carafe, Classic and Under the Sink Units, and $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

The use of calcium channel blocker medications for tachycardias refractory to Adenosine and to lower the blood pressure of hypertensive stroke patients.Calcium is one of the ions that move across the cellular membrane during cardiac contraction and relaxation.The primary use of calcium channel blockers in ACLS.Use of calcium channel blockers for SVT refractory to Adenosine and A-Fib or A-Flutter with RVR.Contraindications of calcium channel blockers.Nicardipine use during the treatment of ischemic strokes.For more information on ACLS medications, tachycardia, or stroke check out the pod resource page at passacls.com.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Free Prescription Discount Card - Get your free drug discount card to save money on prescription medications for you and your pets: https://nationaldrugcard.com/ndc3506/Pass ACLS Web Site - Other ACLS-related resources: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Identification of Atrial Fibrillation (A-Fib) & Atrial Flutter on the ECG and the treatment of unstable and stable SVT patients with A-Fib/Flutter.The ECG characteristics of A-Fib and A-Flutter.Recognition and treatment of unstable patients in A-Fib/Flutter with rapid ventricular response (RVR).Suggested energy settings for synchronized cardioversion of unstable patients with a narrow complex tachycardia.Team safety when cardioverting an unstable patient in A-FIB/Flutter.Adenosine's role for stable SVT patients with underlying atrial rhythms.Treatment of stable patients in A-Fib/Flutter with RVR.For other medical podcasts that cover narrow complex tachycardias, visit the pod resource page at passacls.com.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Free Prescription Discount Card - Get your free drug discount card to save money on prescription medications for you and your pets: https://nationaldrugcard.com/ndc3506/Pass ACLS Web Site - Other ACLS-related resources: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Five articles from the November 2025 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by busy readers who would prefer a brief audio summary in order to select the articles they want to read in full. The featured articles this month are, "Metformin Reduces the Incidence of Shoulder Stiffness After Arthroscopic Rotator Cuff Repair: A Randomized, Double-Blinded, Placebo-Controlled Trial," "Delayed Surgery and Adenosine, Lidocaine, and Mg2+ Immunomodulatory Therapy Improve Joint Recovery in a Sex-Specific Manner After Anterior Cruciate Ligament Reconstruction in a Rat Model," "Comparison of Anchor Hole Enlargement Between Biodegradable and All-Soft Suture Anchors After Arthroscopic Bankart Repair: Longitudinal 2-Year Follow-up Study," "Sports Participation 25 Years After Anterior Cruciate Ligament Reconstruction: A Prospective Longitudinal Study Comparing Patients With Patellar Tendon and Hamstring Tendon Grafting to Uninjured Controls," and "Risk Profile for Cyclops Syndrome Necessitating Reoperation After Anterior Cruciate Ligament Reconstruction." Click here to read the articles.

Review of vagal maneuvers and alternative treatments used in ACLS for stable patients with tachycardia at a rate over 150 bpm.Narrow complex tachycardia with a rate over 150 BPM.Unstable patients in SVT, or V-Tach with a pulse, should be cardioverted with a synchronized shock.Assessment & treatment of stable tachycardic patients.Commonly used vagal techniques.A less common technique to stimulate the vagus nerve.Indications and use of Adenosine.Possible treatments for patients found to be in A-Fib or A-Flutter with RVR after administration of Adenosine.Carotid sinus massage.Additional medical podcasts that have episodes on tachycardia can be found on the pod resources page at passacls.com. **American Cancer Society (ACS) Fundraiser This is the seventh year that I'm participating in Men Wear Pink to increase breast cancer awareness and raise money for the American Cancer Society's life-saving mission.I hope you'll consider contributing.Every donation makes a difference in the fight against breast cancer! Paul Taylor's ACS Fundraiser Page: http://main.acsevents.org/goto/paultaylorTHANK YOU for your support! Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Free Prescription Discount Card - Get your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vip/savePass ACLS Web Site - Other ACLS-related resources: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Review the indications, dosing, & administration of Adenosine for patients in supraventricular tachycardia (SVT) following ACLS's Tachycardia algorithm.Adenosine is the first IV medication given to stable patients with sustained supraventricular tachycardia (SVT) refractory to vagal maneuvers.Symptoms indicating a stable vs unstable patient.Common causes of tachycardia.Cardiac effects of Adenosine.Indications for use in the ACLS Tachycardia algorithm.Considerations and contraindications.Adenosine as a diagnostic for patients in A-Fib or A-Flutter with RVR.Dosing and administration.Other podcasts that cover common ACLS antiarrhythmics in more detail and another covering Brugata Criteria used to differentiate V-Tach from SVT with an aberrancy, can be found on the Pod Resources page at passacls.com.**American Cancer Society (ACS) Fundraiser This is the seventh year that I'm participating in Men Wear Pink to increase breast cancer awareness and raise money for the American Cancer Society's life-saving mission.I hope you'll consider contributing.Every donation makes a difference in the fight against breast cancer! Paul Taylor's ACS Fundraiser Page: http://main.acsevents.org/goto/paultaylorTHANK YOU for your support! Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Free Prescription Discount Card - Get your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vip/savePass ACLS Web Site - Other ACLS-related resources: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

The use of calcium channel blocker medications for tachycardias refractory to Adenosine and to lower the blood pressure of hypertensive stroke patients.Calcium is one of the ions that move across the cellular membrane during cardiac contraction and relaxation.The primary use of calcium channel blockers in ACLS.Use of calcium channel blockers for SVT refractory to Adenosine and A-Fib or A-Flutter with RVR.Contraindications of calcium channel blockers.Nicardipine use during the treatment of ischemic strokes.For more information on ACLS medications, tachycardia, or stroke check out the pod resource page at passacls.com.**American Cancer Society (ACS) Fundraiser This is the seventh year that I'm participating in Men Wear Pink to increase breast cancer awareness and raise money for the American Cancer Society's life-saving mission.I hope you'll consider contributing.Every donation makes a difference in the fight against breast cancer! Paul Taylor's ACS Fundraiser Page: http://main.acsevents.org/goto/paultaylorTHANK YOU for your support! Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Free Prescription Discount Card - Get your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vip/savePass ACLS Web Site - Other ACLS-related resources: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Identification of Atrial Fibrillation (A-Fib) & Atrial Flutter on the ECG and the treatment of unstable and stable SVT patients with A-Fib/Flutter.The ECG characteristics of A-Fib and A-Flutter.Recognition and treatment of unstable patients in A-Fib/Flutter with rapid ventricular response (RVR).Suggested energy settings for synchronized cardioversion of unstable patients with a narrow complex tachycardia.Team safety when cardioverting an unstable patient in A-FIB/Flutter.Adenosine's role for stable SVT patients with underlying atrial rhythms.Treatment of stable patients in A-Fib/Flutter with RVR.For other medical podcasts that cover narrow complex tachycardias, visit the pod resource page at passacls.com. **American Cancer Society (ACS) Fundraiser This is the seventh year that I'm participating in Men Wear Pink to increase breast cancer awareness and raise money for the American Cancer Society's life-saving mission.I hope you'll consider contributing.Every donation makes a difference in the fight against breast cancer! Paul Taylor's ACS Fundraiser Page: http://main.acsevents.org/goto/paultaylorTHANK YOU for your support! Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Free Prescription Discount Card - Get your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vip/savePass ACLS Web Site - Other ACLS-related resources: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

What if one enzyme could link metabolism, epigenetics, and therapy across conditions as diverse as epilepsy, cancer, and inflammation? In this episode, we dive into the fascinating world of adenosine kinase (ADK), an ancient enzyme that controls adenosine levels, energy balance, and even DNA methylation. Dr Detlev Boison join us to discuss their recent review in the Journal of Inherited Metabolic Disease, which reframes ADK not just as a metabolic regulator, but as a potential epigenetic drug target. From seizure suppression to cancer immunology, ADK sits at a crossroads, and could be a future key to metabolic and epigenetic medicine. Adenosine Kinase: An Epigenetic Modulator and Drug Target Uchenna Peter-Okaka, Detlev Boison https://doi.org/10.1002/jimd.70033

  Welcome to the Prehospital Emergency Care Journal Podcast! In this PEC Podcast Deep Dive, Rebecca Cash and Maia Dorsett interview Dr. Tony Fernandez about his recent PEC paper comparing initial prehospital adenosine doses of 6 mg versus 12 mg for presumed SVT. We explore the study's origins, dataset design, and results—including the finding that starting with 12 mg was associated with higher rates of cardioversion and fewer redoses without an increase in complications. Along the way, we discuss the quirks of EMS data, why some “standard” practices exist without strong evidence, and how retrospective studies fit into the bigger picture of protocol change. For those whose interest in study methods was piqued, here's a great short primer on odds ratios versus relative risk: https://www.youtube.com/watch?v=dWtzaKYFg00&t=175s Featured Article Fernandez, A. R., Bourn, S. S., Duncan, D., Slovis, C. M., Crowe, R. P., Treichel, A., & Myers, J. B. (2025). Comparing Prehospital Adenosine Initial Dosing of 6 mg Versus 12 mg for Presumed Paroxysmal Supraventricular Tachycardia (PSVT). Prehospital Emergency Care, 1–6. https://doi.org/10.1080/10903127.2025.2504521

Patients with a narrow complex tachycardia with a rate over 150 BPM are in SVT.Unstable patients in SVT, or V-Tach with a pulse, should be cardioverted with a synchronized shock. Assessment & treatment of stable tachycardic patients.Commonly used vagal techniques.A less common technique to stimulate the vagus nerve. Indications and use of Adenosine for stable patients in SVT refractory to vagal maneuvers.Possible treatments for patients found to be in A-Fib or A-Flutter with RVR after administration of Adenosine.Carotid sinus massage.Additional medical podcasts that have episodes on tachycardia can be found on the pod resources page at passacls.com. **American Cancer Society (ACS) Fundraiser This is the seventh year that I'm participating in Men Wear Pink to increase breast cancer awareness and raise money for the American Cancer Society's life-saving mission.I hope you'll consider contributing.Every donation makes a difference in the fight against breast cancer! Paul Taylor's ACS Fundraiser Page: http://main.acsevents.org/goto/paultaylorTHANK YOU for your support! Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Free Prescription Discount Card - Get your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vip/savePass ACLS Web Site - Other ACLS-related resources: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Adenosine is the first IV medication given to stable patients with sustained supraventricular tachycardia (SVT) refractory to vagal maneuvers.Symptoms indicating a stable vs unstable patient.Common causes of tachycardia.Cardiac effects of Adenosine. Indications for use in the ACLS Tachycardia algorithm.Considerations and contraindications. Adenosine as a diagnostic for patients in A-Fib or A-Flutter with RVR.Dosing and administration.Other podcasts that cover common ACLS antiarrhythmics in more detail and another covering Brugata Criteria used to differentiate V-Tach from SVT with an aberrancy, can be found on the Pod Resources page at passacls.com.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Free Prescription Discount Card - Get your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vip/savePass ACLS Web Site - Other ACLS-related resources: https://passacls.com@Pass-ACLS-Podcast on LinkedIn **American Cancer Society (ACS) Fundraiser This is the seventh year that I'm participating in Men Wear Pink to increase breast cancer awareness and raise money for the American Cancer Society's life-saving mission.I hope you'll consider contributing.Every donation makes a difference in the fight against breast cancer! Paul Taylor's ACS Fundraiser Page: http://main.acsevents.org/goto/paultaylorTHANK YOU for your support!

Your life literally depends on sleep, and in this eye-opening exploration of sleep science, we reveal why this nighttime process might be the most undervalued health tool in your arsenal.Sleep isn't merely a passive state where your body shuts down. It's an intricately choreographed series of stages, each with distinct physiological purposes that keep your body and mind functioning optimally. We journey through the four sleep stages that make up each 60-90 minute cycle, from light sleep transitions to the deep restorative phases where physical healing happens, and finally to REM sleep where emotional processing and memory consolidation occur.Behind this complex sleep architecture lies a fascinating hormonal dance. Adenosine builds up throughout your day creating "sleep pressure," while melatonin responds to darkness to signal bedtime. Cortisol prepares you for morning alertness, and insulin regulation depends on quality sleep. When this delicate system gets disrupted, the consequences are far more serious than just feeling tired - a single night of poor sleep can reduce immune function by 70%, temporarily induce pre-diabetic conditions, and accelerate aging biomarkers.For those struggling with sleep, I'll offer practical, evidence-based strategies you can implement tonight: creating a wind-down routine, limiting blue light exposure, establishing consistent sleep-wake times, optimizing bedroom temperature, and more. The science is clear, prioritizing sleep isn't self-indulgent; it's essential maintenance for your body and brain. Better brain function, stronger immunity, stable mood, and even weight management all depend on those precious hours of rest. Ready to transform your health? Start with better sleep.Go check out my website for tons of free resources on how to transition towards a healthier diet and lifestyle.You can download my free plant-based recipes eBook and a ton of other free resources by visiting the Digital Downloads tab of my website at https://www.plantbaseddrjules.com/shopDon't forget to check out my blog at https://www.plantbaseddrjules.com/blog You can also watch my educational videos on YouTube at https://www.youtube.com/channel/UCMpkQRXb7G-StAotV0dmahQCheck out my upcoming live events and free eCourse, where you'll learn more about how to create delicious plant-based recipes: https://www.plantbaseddrjules.com/Go follow me on social media by visiting my Facebook page and Instagram accountshttps://www.facebook.com/plantbaseddrjuleshttps://www.instagram.com/plantbased_dr_jules/Last but not least, the best way to show your support and to help me spread my message is to subscribe to my podcast and to leave a 5 star review on Apple and Spotify!Thanks so much!Peace, love, plants!Dr. Jules

Calcium is one of the ions that move across the cellular membrane during cardiac contraction and relaxation.The primary use of calcium channel blockers in ACLS.Use of calcium channel blockers for SVT refractory to Adenosine and A-Fib or A-Flutter with RVR.Contraindications of calcium channel blockers.Nicardipine use during the treatment of ischemic strokes.For more information on ACLS medications, tachycardia, or stroke check out the pod resource page at passacls.com.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Free Prescription Discount Card - Download your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vipPass ACLS Web Site - Episode archives & other ACLS-related podcasts: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

We just got a new paper that compares initial treatment with adenosine compared with diltiazem for the treatment of adults with SVT in the ED. Wouldn't it be great if it turned out that diltiazem was just as effective, if not more effective, as adenosine without the crappy feeling? Yeah, that'd be great, but what do we do with statistically insignificant results. Is there, perhaps, a way to save this “insignificant” paper? Fear not, Bayes is here! Yes, that's right, Dr. Jarvis is grabbing this new paper and diving straight back into that deep dark rabbit hole of Bayesian analysis. Citation:1.     Lee CA, Morrissey B, Chao K, Healy J, Ku K, Khan M, Kinteh E, Shedd A, Garrett J, Chou EH: Adenosine Versus Fixed-Dose Intravenous Bolus Diltiazem on Reversing Supraventricular Tachycardia in The Emergency Department: A Multi-Center Cohort Study. The Journal of Emergency Medicine. 2025;August 1;75:55–64. FAST25 | May 19-21, 2025 | Lexington, KY

In atrial fibrillation (A-Fib) and atrial flutter (A-Flutter) the electrical impulse for cardiac contraction is in the atria but isn't the normal pacemaker of the heart, the SA node. The ECG characteristics of A-Fib and A-Flutter. Recognition and treatment of unstable patients in A-Fib/Flutter with rapid ventricular response (RVR).Suggested energy settings for synchronized cardioversion of unstable patients with a narrow complex tachycardia. Team safety when cardioverting an unstable patient in A-FIB/Flutter.Adenosine's role for stable SVT patients with underlying atrial rhythms.Treatment of stable patients in A-Fib/Flutter with RVR.For other medical podcasts that cover narrow complex tachycardias, visit the pod resource page at passacls.com. Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Free Prescription Discount Card - Download your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vipPass ACLS Web Site - Episode archives & other ACLS-related podcasts: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Patients with a narrow complex tachycardia with a rate over 150 BPM are in SVT.Unstable patients in SVT or V-Tach with a pulse, should be cardioverted with a synchronized shock. Assessment & treatment of stable tachycardic patients.Commonly used vagal techniques.A less common technique to stimulate the vagus nerve. Indications and use of Adenosine for stable patients in SVT refractory to vagal maneuvers.Possible treatments for patients found to be in A-Fib or A-Flutter with RVR after administration of Adenosine.Carotid sinus massage.Additional medical podcasts that have episodes on tachycardia can be found on the pod resources page at passacls.com. Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Free Prescription Discount Card - Download your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vipPass ACLS Web Site - Episode archives & other ACLS-related podcasts: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Adenosine is the first IV medication given to stable patients with sustained supraventricular tachycardia (SVT) refractory to vagal maneuvers.Symptoms indicating a stable vs unstable patient.Common causes of tachycardia.Cardiac effects of Adenosine. Indications for use in the ACLS Tachycardia algorithm.Considerations and contraindications. Adenosine as a diagnostic for patients in A-Fib or A-Flutter with RVR.Dosing and administration.Other podcasts that cover common ACLS antiarrhythmics in more detail and another covering Brugata Criteria used to differentiate V-Tach from SVT with an aberrancy, can be found on the Pod Resources page at passacls.com.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Free Prescription Discount Card - Download your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vipPass ACLS Web Site - Episode archives & other ACLS-related podcasts: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Calcium is one of the ions that move across the cellular membrane during cardiac contraction and relaxation.The primary use of calcium channel blockers in ACLS is for the treatment of stable, narrow complex tachycardias refractory to Adenosine and to lower the blood pressure of ischemic stroke patients with severe hypertension.Use of calcium channel blockers for SVT refractory to Adenosine and A-Fib or A-Flutter with RVR.Contraindications of calcium channel blockers.Nicardipine use during the treatment of ischemic strokes.For more information on ACLS medications, tachycardia, or stroke check out the pod resource page at passacls.com.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Free Prescription Discount Card - Download your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vipPass ACLS Web Site - Episode archives & other ACLS-related podcasts: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

In atrial fibrillation (A-Fib) and atrial flutter (A-Flutter) the electrical impulse for cardiac contraction is in the atria but isn't the normal pacemaker of the heart, the SA node. The ECG characteristics of A-Fib and A-Flutter. Recognition and treatment of unstable patients in A-Fib/Flutter with rapid ventricular response (RVR).Suggested energy settings for synchronized cardioversion of unstable patients with a narrow complex tachycardia. Team safety when cardioverting an unstable patient in A-FIB/Flutter.Adenosine's role for stable SVT patients with underlying atrial rhythms.Treatment of stable patients in A-Fib/Flutter with RVR. For other medical podcasts that cover narrow complex tachycardias, visit the pod resource page at passacls.com. Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Free Prescription Discount Card - Download your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vip/savePass ACLS Web Site - Episode archives & other ACLS-related podcasts: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Contributor: Travis Barlock, MD Educational Pearls: Key clinical considerations when managing heart transplant patients due to their unique pathophysiology 1. Arrhythmias A transplanted heart is denervated, meaning it lacks autonomic nervous system innervation The lack of vagal tone results in an increased resting heart rate Adenosine can be used since it primarily slows conduction through the AV node  Atropine is ineffective in treating transplant bradyarrhythmia because its mechanism is to inhibit the vagus nerve - but the heart lacks vagal tone Allograft rejection can also cause tachycardia Consult transplant surgery - treatment is usually 500 mg methylprednisolone 2. Rejection Transplant patients are administered immunosuppressants Clinical presentation of acute rejection looks similar to heart failure with increased BNP, increased troponin, and pulmonary edema  Cardiac allograft vasculopathy is a form of chronic rejection Patients will not report chest pain due to denervated heart Symptoms are usually weakness and fatigue 3. High risk of infection due to immunosuppression Increased risk of infections which includes CMV, legionella, tuberculosis, etc Immunosuppressants have side effects such as acute kidney injury or pancytopenia 4. Radiographic Cardiomegaly A study found that radiographic cardiomegaly does not connote heart failure They hypothesized it is instead the result of a mismatch between the size of the transplanted heart and the space in the thoracic cavity  References Murphy JD, Mergo PJ, Taylor HM, Fields R, Mills RM Jr. Significance of radiographic cardiomegaly in orthotopic heart transplant recipients. AJR Am J Roentgenol. 1998 Aug;171(2):371-4. doi: 10.2214/ajr.171.2.9694454. PMID: 9694454. Park MH, Starling RC, Ratliff NB, McCarthy PM, Smedira NS, Pelegrin D, Young JB. Oral steroid pulse without taper for the treatment of asymptomatic moderate cardiac allograft rejection. J Heart Lung Transplant. 1999 Dec;18(12):1224-7. doi: 10.1016/s1053-2498(99)00098-4. PMID: 10612382. Pethig K, Heublein B, Wahlers T, Dannenberg O, Oppelt P, Haverich A. Mycophenolate mofetil for secondary prevention of cardiac allograft vasculopathy: influence on inflammation and progression of intimal hyperplasia. J Heart Lung Transplant. 2004 Jan;23(1):61-6. doi: 10.1016/s1053-2498(03)00097-4. PMID: 14734128. Summarized by Meg Joyce, MS1 | Edited by Meg Joyce & Jorge Chalit, OMS3 Donate: https://emergencymedicalminute.org/donate/  

Patients with a narrow complex tachycardia with a rate over 150 BPM are in SVT.Unstable patients in SVT, or V-Tach with a pulse, should be cardioverted with a synchronized shock. Assessment & treatment of stable tachycardic patients.Commonly used vagal techniques.A less common technique to stimulate the vagus nerve is the dive reflex. Indications and use of Adenosine for stable patients in SVT refractory to vagal maneuvers.Possible treatments for patients found to be in A-Fib or A-Flutter with RVR after administration of Adenosine. Carotid sinus massage.Additional medical podcasts that have episodes on tachycardia can be found on the pod resources page at passacls.com. Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Safe Meds VIP - Learn about medication safety and download a free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vipPass ACLS Web Site - Episode archives & other ACLS-related podcasts: https://passacls.com@Pass-ACLS-Podcast on LinkedIn

Adenosine is the first IV medication given to stable patients with sustained supraventricular tachycardia (SVT) refractory to vagal maneuvers. Symptoms indicating a stable vs unstable patient. Common causes of tachycardia. Cardiac effects of Adenosine. Indications for use in the ACLS Tachycardia algorithm.Considerations and contraindications. Adenosine as a diagnostic for patients in A-Fib or A-Flutter with RVR.Dosing and administration.Other podcasts that cover common ACLS antiarrhythmics in more detail and another covering Brugata Criteria used to differentiate V-Tach from SVT with an aberrancy, can be found on the Pod Resources page at passacls.com.Connect with me:Website: https://passacls.com@Pass-ACLS-Podcast on LinkedInOther Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Save money on prescription medications for you and your pets: https://nationaldrugcard.com/ndc3506*Commissions may be earned from the above links.Good luck with your ACLS class!

Calcium is one of the ions that move across the cellular membrane during cardiac contraction and relaxation. The primary use of calcium channel blockers in ACLS is for the treatment of stable, narrow complex tachycardias refractory to Adenosine and to lower the blood pressure of ischemic stroke patients with severe hypertension.Use of calcium channel blockers for SVT refractory to Adenosine and A-Fib or A-Flutter with RVR.Contraindications of calcium channel blockers. Nicardipine use during the treatment of ischemic strokes.For more information on ACLS medications, tachycardia, or stroke check out the pod resource page at passacls.com.Connect with me:Website: https://passacls.com@Pass-ACLS-Podcast on LinkedInGive Back & Help Others: Your support helps cover the monthly cost of software and podcast & website hosting. Donations at Buy Me a Coffee at https://buymeacoffee.com/paultaylor are appreciated and will help ensure others can benefit from these tips as well.Good luck with your ACLS class!Helpful Listener Links:Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/*FREE to anyone in the U.S. Save $$ on prescription medications for you and your pets with National Drug Card - https://nationaldrugcard.com/ndc3506 *Indicates affiliate links. I may get paid a small commission if you purchase products or memberships using my link. It doesn't affect the price you pay.

In atrial fibrillation (A-Fib) and atrial flutter (A-Flutter) the electrical impulse for cardiac contraction is in the atria but isn't the normal pacemaker of the heart, the SA node. The ECG characteristics of A-Fib and A-Flutter. Recognition and treatment of unstable patients in A-Fib/Flutter with rapid ventricular response (RVR). Suggested energy settings for synchronized cardioversion of unstable patients with a narrow complex tachycardia. Team safety when cardioverting an unstable patient in A-FIB/Flutter. Adenosine's role for stable SVT patients with underlying atrial rhythms. Treatment of stable patients in A-Fib/Flutter with RVR. For other medical podcasts that cover narrow complex tachycardias, visit the pod resource page at passacls.com. Connect with me:Website: https://passacls.com@Pass-ACLS-Podcast on LinkedInGive Back & Help Others: Your support helps cover the monthly cost of software and podcast & website hosting. Donations at Buy Me a Coffee at https://buymeacoffee.com/paultaylor are appreciated and will help ensure others can benefit from these tips as well.Good luck with your ACLS class!Helpful Listener Links:Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/*FREE to anyone in the U.S. Save $$ on prescription medications for you and your pets with National Drug Card - https://nationaldrugcard.com/ndc3506 *Indicates affiliate links. I may get paid a small commission if you purchase products or memberships using my link. It doesn't affect the price you pay.

Psychologist Maria Ruberto is back to talk about one of the most important parts of our day: sleep. Starting off with the biology of sleep, Maria takes us through how we get to sleep, what happens when we sleep, and why we desperately need to sleep for good health and longevity. With metaphors galore to make the science as relatable as possible, we discuss the role of melatonin, the impact of screens on our suprachiasmatic nucleus and whether it’s worth cutting your sleep short to exercise? In more practical terms, Maria shares what sleep hygiene actually looks like, and, to Hugh and Josh’s relief, how hormones released during parenthood act to buffer against sleep deprivation. So set your sleep alarms, get comfy, and tuck yourself in for a BIG episode! Sweet dreams x If you would like to watch this full video on YouTub, follow this link: https://bit.ly/4htdJLj If you’d like to subscribe to our Patreon, A Little More Imperfects, sign up here: Patreon.com/theimperfects

No matter how much sleep you get, do you always wake up feeling like you've been hit by a bus? Turns out, it's more common than you might think. In this episode, I share my own journey of figuring out why I was always tired and the surprising solution that had been right in front of me the whole time.For more go to: www.scottmlynch.comThis episode is brought to you by:BetterHelpLevel up your life by joining my Patreon where you'll get exclusive content every week and more badass offerings (rips t-shirt in half, Hulk Hogan style, and runs around the room). And/or…Unlock practical and tactical insights on how to master your mindset and optimize your happiness directly to your inbox.If you're a glutton for punishment and want more swift kicks in the mind follow me on social:InstagramYouTubeLeave a review and tell me how I suck so I can stop doing that or you can also tell me about things you like. I'd be okay with that, too.Produced by ya boi.Past guests on The Motivated Mind include Chris Voss, Captain Sandy, Dr. Chris Palmer, Joey Thurman, Jason Harris, Koshin Paley Ellison, Rudy Mawer, Molly Fletcher, Kristen Butler, Hasard Lee, Natasha Graziano, ⁠David Hauser⁠, Cheryl Hunter, Michael Brandt, Heather Moyse, Tim Shriver, and Alan Stein, Jr.

Patients with a narrow complex tachycardia with a rate over 150 BPM are in SVT. Unstable patients in SVT, or V-Tach with a pulse, should be cardioverted with a synchronized shock. Assessment & treatment of stable tachycardic patients.Commonly used vagal techniques.A less common technique to stimulate the vagus nerve is the dive reflex. Indications and use of Adenosine for stable patients in SVT refractory to vagal maneuvers.Possible treatments for patients found to be in A-Fib or A-Flutter with RVR after administration of Adenosine.Carotid sinus massage.Additional medical podcasts that have episodes on tachycardia can be found on the pod resources page at passacls.com. Connect with me:Website: https://passacls.com@Pass-ACLS-Podcast on LinkedInGive Back & Help Others: Your support helps cover the monthly cost of software and podcast & website hosting so that others can benefit from these ACLS tips as well. Donations via Buy Me a Coffee at https://buymeacoffee.com/paultaylor are appreciated.Good luck with your ACLS class!

Adenosine is the first IV medication given to stable patients with sustained supraventricular tachycardia (SVT) refractory to vagal maneuvers.Symptoms indicating a stable vs unstable patient. Common causes of tachycardia. Cardiac effects of Adenosine. Indications for use in the ACLS Tachycardia algorithm. Considerations and contraindications. Adenosine as a diagnostic for patients in A-Fib or A-Flutter with RVR. Dosing and administration. Other podcasts that cover common ACLS antiarrhythmics in more detail and another covering Brugata Criteria used to differentiate V-Tach from SVT with an aberrancy, can be found on the Pod Resources page at passacls.com.Connect with me:Website: https://passacls.com@Pass-ACLS-Podcast on LinkedInGive Back & Help Others: Your support helps cover the monthly cost of software and podcast & website hosting so that others can benefit from these ACLS tips as well. Donations via Buy Me a Coffee at https://buymeacoffee.com/paultaylor are appreciated.Good luck with your ACLS class!

Dr. Pui Y. Lee, a pediatric rheumatologist, leading researcher and clinician, joins us today to lend his insights on Deficiency of Adenosine Deaminase 2 or “DADA 2”. What is this disease and how common is it? What is the underlying pathophysiology, the role of genetic screening and the most useful diagnostic tools? We'll also cover treatment options for DADA 2, the prognosis most patients face, plus the future of research for this condition. 

Calcium is one of the ions that move across the cellular membrane during cardiac contraction and relaxation. The primary use of calcium channel blockers in ACLS is for the treatment of stable, narrow complex tachycardias refractory to Adenosine and to lower the blood pressure of ischemic stroke patients with severe hypertension.Use of calcium channel blockers for SVT refractory to Adenosine and A-Fib or A-Flutter with RVR.Contraindications of calcium channel blockers. Nicardipine use during the treatment of ischemic strokes. For more information on ACLS medications, tachycardia, or stroke check out the pod resource page at passacls.com.Connect with me:Website: https://passacls.com@Pass-ACLS-Podcast on LinkedInGive Back & Help Others: Your support helps cover the monthly cost of software and podcast & website hosting so that others can benefit from these ACLS tips as well. Donations via Buy Me a Coffee at https://buymeacoffee.com/paultaylor are appreciated.Good luck with your ACLS class!

This is the second episode of Huberman Lab Essentials — short episodes (approximately 30 minutes) focused on essential science and protocol takeaways from past Huberman Lab episodes. This Essentials episode offers insights into what makes us sleepy, helps us sleep soundly, and feel awake and alert. It covers a wide range of tools for anyone looking to improve their sleep and wakefulness, with the science and reasoning behind each tool explained. Essentials will be released every Thursday, and our full-length episodes will still be released every Monday. Access the full show notes for this episode at hubermanlab.com.  Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman ROKA: https://roka.com/huberman Timestamps 00:00:00 Introduction to Huberman Lab Essentials 00:00:18 Understanding Sleep & Wakefulness 00:01:11 The Role of Adenosine & Caffeine 00:03:45 Circadian Rhythms & the Importance of Light 00:04:54 Morning Light Exposure & Cortisol 00:06:27 Sponsor: AG1 00:16:14 Evening Light Exposure & Melatonin 00:18:08: Sponsor: Eight Sleep 00:19:47 Managing Light Exposure for Better Sleep 00:28:03 The Benefits of Naps & Yoga Nidra 00:29:06 Sponsor: ROKA 00:34:38 Supplements for Sleep & Wakefulness 00:38:42 Conclusion & Final Thoughts Disclaimer & Disclosures

Patients with a narrow complex tachycardia with a rate over 150 BPM are in SVT. Unstable patients in SVT, or V-Tach with a pulse, should be cardioverted with a synchronized shock. Assessment & treatment of stable tachycardic patients. Commonly used vagal techniques. A less common technique to stimulate the vagus nerve is the dive reflex. Indications and use of Adenosine for stable patients in SVT refractory to vagal maneuvers. Possible treatments for patients found to be in A-Fib or A-Flutter with RVR after administration of Adenosine. Carotid sinus massage. Additional medical podcasts that have episodes on tachycardia can be found on the pod resources page at passacls.com. Connect with me:Website: https://passacls.com@Pass-ACLS-Podcast on LinkedInGive Back & Help Others: Your support helps cover the monthly cost of software and podcast & website hosting so that others can benefit from these ACLS tips as well. Donations made via Buy Me a Coffee at https://buymeacoffee.com/paultaylor are appreciated.Make a difference in the fight against breast cancer by donating to my Men Wear Pink fundraiser for the American Cancer Society (ACS) at http://main.acsevents.org/goto/paultaylor Every dollar helps in the battle with breast cancer.Good luck with your ACLS class!

Adenosine is the first IV medication given to stable patients with sustained supraventricular tachycardia (SVT) refractory to vagal maneuvers. Symptoms indicating a stable vs unstable patient. Common causes of tachycardia. Cardiac effects of Adenosine. Indications for use in the ACLS Tachycardia algorithm. Considerations and contraindications. Adenosine as a diagnostic for patients in A-Fib or A-Flutter with RVR. Dosing and administration.Other podcasts that cover common ACLS antiarrhythmics in more detail and another covering Brugata Criteria used to differentiate V-Tach from SVT with an aberrancy, can be found on the Pod Resources page at passacls.com.Connect with me:Website: https://passacls.com@Pass-ACLS-Podcast on LinkedInGive Back & Help Others: Your support helps cover the monthly cost of software and podcast & website hosting so that others can benefit from these ACLS tips as well. Donations made via Buy Me a Coffee at https://buymeacoffee.com/paultaylor are appreciated.Make a difference in the fight against breast cancer by donating to my Men Wear Pink fundraiser for the American Cancer Society (ACS) at http://main.acsevents.org/goto/paultaylor Every dollar helps in the battle with breast cancer.Good luck with your ACLS class!

Enjoy this re-release of one my top listened to episodes with my guest, Chris Winter,Today, we're diving deep into the intricacies of sleep with renowned sleep expert and neurologist, Chris Winter. With over 10,000 patients under his care, including elite athletes, Chris has transformed lives through improved sleep. We'll explore fascinating topics such as the role of adenosine in sleepiness, the impact of caffeine, and the controversial concept of sleep debt. Chris will share practical advice on maintaining a consistent wake-up routine, optimizing your sleep environment, and debunking common sleep myths. Whether you're a college student, a high-powered professional, or just someone seeking better sleep, you'll find actionable insights in this episode. Plus, we'll touch on the cognitive effects of sleep deprivation, the significance of circadian rhythms, and how genetics play into our sleep needs. [06:29] The Glymphatic System and its Impact on Alzheimer's Disease: How Sleep Can Help Delay the Onset of the Disease.[10:26] Sleep Deprivation: The Connection Between Sleep Deprivation, Brain Fog, and Increased Risk for Accidents and Dementia.[25:53] Finding Your Optimal Sleep Duration: The Minimum Hours of Sleep Required for Optimal Health and Productivity.[36:13] The Drive Reduction Theory: How Your Body Forces You to Get Better Sleep.[41:26] The Science Behind Sleep: Homeostasis, Circadian Rhythm, Adenosine, Melatonin, and Caffeine.[46:11] The Truth About Caffeine: How Caffeine Tolerance Affects Your Brain and Sleep? [51:12] Understanding Sleep Debt: Can We Really Make Up for Lost Sleep?[56:11] Expert Insights: The Importance of Consistent Wake-Up Times for Better Sleep.[01:01:25] Optimizing Your Sleep: The Importance of Sleep Hygiene and Creating Your Hibernation Lair.[01:13:06] The Power of a Bedtime Routine: Tips for a Consistent and Healthy Sleep Schedule.Resources:Connect with Chris:Website: wchriswinter.com/Youtube: https://www.youtube.com/@SleepUnpluggedPodcastInstagram: instagram.com/drchriswintervTwitter: https://twitter.com/drchriswinterPodcast: Sleep Unplugged with Dr. Chris Winter: podcasts.apple.com/us/podcast/sleep-unplugged-with-dr-chris-winter/id1631914841Books by Dr. Chris Winter:The Sleep Solution: Why Your Sleep is Broken and How to Fix ItThe Rested Child: Why Your Tired, Wired or Irritable Child May have a Sleep Disorder -- and How to HelpBooks Mentioned in the Podcast:Book by Samuel Shem: The House of GodBook by Joseph Heller: Catch-22

Calcium is one of the ions that move across the cellular membrane during cardiac contraction and relaxation. The primary use of calcium channel blockers in ACLS is for the treatment of stable, narrow complex tachycardias refractory to Adenosine and to lower the blood pressure of ischemic stroke patients with severe hypertension.Use of calcium channel blockers for SVT refractory to Adenosine and A-Fib or A-Flutter with RVR.Contraindications of calcium channel blockers. Nicardipine use during the treatment of ischemic strokes.For more information on ACLS medications, tachycardia, or stroke check out the pod resource page at passacls.com.Connect with me:Website: https://passacls.com@Pass-ACLS-Podcast on LinkedInGive Back & Help Others: Your support helps cover the monthly cost of software and podcast & website hosting so that others can benefit from these ACLS tips as well. Donations made via Buy Me a Coffee at https://buymeacoffee.com/paultaylor are appreciated.Make a difference in the fight against breast cancer by donating to my Men Wear Pink fundraiser for the American Cancer Society (ACS) at http://main.acsevents.org/goto/paultaylor Every dollar helps in the battle with breast cancer.Good luck with your ACLS class!

In atrial fibrillation (A-Fib) and atrial flutter (A-Flutter) the electrical impulse for cardiac contraction is in the atria but isn't the normal pacemaker of the heart, the SA node. The ECG characteristics of A-Fib and A-Flutter. Recognition and treatment of unstable patients in A-Fib/Flutter with rapid ventricular response (RVR).Suggested energy settings for synchronized cardioversion of unstable patients with a narrow complex tachycardia. Team safety when cardioverting an unstable patient in A-FIB/Flutter.Adenosine's role for stable SVT patients with underlying atrial rhythms. Treatment of stable patients in A-Fib/Flutter with RVR.For other medical podcasts that cover narrow complex tachycardias, visit the pod resource page at passacls.com. Connect with me:Website: https://passacls.com@Pass-ACLS-Podcast on LinkedInGive Back & Help Others: Your support helps cover the monthly cost of software and podcast & website hosting so that others can benefit from these ACLS tips as well. Donations made via Buy Me a Coffee at https://buymeacoffee.com/paultaylor are appreciated.Make a difference in the fight against breast cancer by donating to my Men Wear Pink fundraiser for the American Cancer Society (ACS) at http://main.acsevents.org/goto/paultaylor Every dollar helps in the battle with breast cancer.Good luck with your ACLS class!

Contributor: Travis Barlock, MD Educational Pearls: SVT: supraventricular tachycardia Pharmacotherapy for SVT includes drugs that block the AV node, such as adenosine EKG criteria before adenosine administration in SVT Regular rhythm Monomorphic: ​​all QRS complexes are identical If the EKG is polymorphic, with QRS complexes displaying changing morphologies, it is unsafe to administer adenosine  Adenosine can worsen polymorphic VTach and lead to VFib References Ganz, Leonard I., and Peter L. Friedman. “Supraventricular Tachycardia.” New England Journal of Medicine, vol. 332, no. 3, 19 Jan. 1995, pp. 162–173, https://doi.org/10.1056/nejm199501193320307. Smith JR, Goldberger JJ, Kadish AH. Adenosine induced polymorphic ventricular tachycardia in adults without structural heart disease. Pacing Clin Electrophysiol. 1997;20(3 Pt 1):743-745. doi:10.1111/j.1540-8159.1997.tb03897.x Viskin, Sami, et al. “Polymorphic Ventricular Tachycardia: Terminology, Mechanism, Diagnosis, and Emergency Therapy.” Circulation, vol. 144, no. 10, 7 Sept. 2021, pp. 823–839, https://doi.org/10.1161/circulationaha.121.055783. Summarized by Meg Joyce, MS1 | Edited by Meg Joyce & Jorge Chalit, OMS3  

Patients with a narrow complex tachycardia with a rate over 150 BPM are in SVT. Unstable patients in SVT, or V-Tach with a pulse, should be cardioverted with a synchronized shock. Assessment & treatment of stable tachycardic patients. Commonly used vagal techniques. A less common technique to stimulate the vagus nerve is the dive reflex. Indications and use of Adenosine for stable patients in SVT refractory to vagal maneuvers.Possible treatments for patients found to be in A-Fib or A-Flutter with RVR after administration of Adenosine. Carotid sinus massage. Additional medical podcasts that have episodes on tachycardia can be found on the pod resources page at passacls.com. Connect with me:Website: https://passacls.com@Pass-ACLS-Podcast on LinkedInGive Back & Help Others: Your support helps cover the monthly cost of software and podcast & website hosting so that others can benefit from these ACLS tips as well. Donations made via Buy Me a Coffee at https://buymeacoffee.com/paultaylor are appreciated.Make a difference in the fight against breast cancer by donating to my Men Wear Pink fundraiser for the American Cancer Society (ACS) at http://main.acsevents.org/goto/paultaylor Every dollar helps in the battle with breast cancer.Good luck with your ACLS class!

Adenosine is the first IV medication given to stable patients with sustained supraventricular tachycardia (SVT) refractory to vagal maneuvers.Symptoms indicating a stable vs unstable patient.Common causes of tachycardia. Cardiac effects of Adenosine. Indications for use in the ACLS Tachycardia algorithm. Considerations and contraindications. Adenosine as a diagnostic for patients in A-Fib or A-Flutter with RVR.Dosing and administration. Other podcasts that cover common ACLS antiarrhythmics in more detail and another covering Brugata Criteria used to differentiate V-Tach from SVT with an aberrancy, can be found on the Pod Resources page at passacls.com.Connect with me:Website: https://passacls.com@PassACLS on X (formally known as Twitter)@Pass-ACLS-Podcast on LinkedInGive back & help others. Your support will help cover the monthly cost of software and podcast & website hosting. Donations made via Buy Me a Coffee at https://buymeacoffee.com/paultaylor are appreciated.Good luck with your ACLS class!

We've recently had several challenging, wide-complex tachycardia cases here at MCHD, so the podcast crew decided to bring forth some VT vs. SVT with aberrancy knowledge. Learn the V-Tach FACT, and you'll feel more comfortable with your next wide rhythm at a rate of 185. REFERENCES 1. https://litfl.com/vt-versus-svt-ecg-library/ 2. https://www.youtube.com/watch?v=UXh8PS9dtmo 3. Marill KA, Wolfram S, Desouza IS, Nishijima DK, Kay D, Setnik GS, Stair TO, Ellinor PT. Adenosine for wide-complex tachycardia: efficacy and safety. Crit Care Med. 2009 Sep;37(9):2512-8.

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 2682: Ana Gotter, in partnership with Healthline.com, demystifies the caffeine withdrawal process, providing a comprehensive look at its duration, symptoms, and management strategies. Gotter's insights into the physiological and psychological effects of caffeine withdrawal, backed by scientific studies, offer valuable guidance for those contemplating a break from caffeine, emphasizing genetic influences on our coffee cravings and how to navigate withdrawal with minimal discomfort. Read along with the original article(s) here: https://www.healthline.com/health/how-long-does-caffeine-withdrawal-last Quotes to ponder: "The duration of caffeine withdrawal symptoms vary from person to person, but caffeine withdrawal usually lasts at least two to nine days." "Caffeine is a psychoactive stimulant that decreases drowsiness by blocking adenosine receptors. Adenosine is a neurotransmitter connected to the body's sleep-wake processes." "If you decide you want to decrease or quit caffeine, try these things to work through your withdrawal symptoms: Taper consumption instead of going cold turkey." Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode 1 of a 6-part special series on sleep with Dr. Matthew Walker, Ph.D., professor of neuroscience and psychology and founder of the Center for Human Sleep Science at the University of California, Berkeley, and the author of the book “Why We Sleep” discusses the essential role that sleep plays in our health. We cover how sleep affects our hormones, immune system, learning and memory, mood, appetite, and weight regulation. We also discuss what causes the urge to sleep, how sleep is structured throughout the night, and the biology of the different phases of sleep. We also teach you how to determine your individualized sleep needs, including your chronotype (best waking and to-bed time), tips for combat snoring and insomnia, and your QQRT (Quality, Quantity, Regularity, and Timing)—a key framework for optimizing your sleep and therefore daytime energy and focus, and overall health. The next episode in this special series explores how to improve one's sleep. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman  BetterHelp: https://betterhelp.com/huberman  LMNT: https://drinklmnt.com/huberman  InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Importance of Sleep (00:02:24) Sponsors: Eight Sleep, BetterHelp & LMNT (00:06:00) Sleep; Non-REM & REM Sleep (00:11:40) Sleep Cycles, Individuality, Women vs. Men (00:14:49) Tool: Wakefulness in Bed, Insomnia (00:19:08) Non-REM Stages of Sleep (00:27:05) Role of Deep Sleep (00:34:02) Sponsor: AG1 (00:35:15) Light Sleep Stages, Hypnogogic Jerks (00:42:00) REM Sleep, Paralysis & Bizarre Dreams; “Falling” Asleep (00:49:09) Tools: Body Position & Sleep; Snoring & Sleep Apnea (00:57:43) Yawning & Theories, Contagion (01:04:03) Nodding Off, Afternoon & Postprandial Dip (01:08:46) Sponsor: InsideTracker (01:09:51) Sleep, Animals & Evolution (01:14:09) Poor Sleep & Health Consequences, Sleep Deprivation (01:27:13) Positive Effects of Good Sleep, Health Improvements (01:31:56) Sleep & Mood; Appetite & Weight Management (01:42:55) Sleep Deprivation & Looking Tired, “Beauty Sleep” (01:47:57) Tool: Getting Good Sleep, QQRT Macros, Quantity & Quality (01:56:45) Tool: Sleep Regularity, Mortality Risk (02:03:15) Tool: Sleep Timing, Chronotypes (02:14:21) Chronotypes & Insomnia, Circadian Rhythm, Shift Work (02:20:31) Tool: Sleep Tests, Alarm Clock, Micro-Sleeps (02:27:27) Sleep Inertia & Waking; Afternoon Dip, Optimum Performance (02:34:19) Causes of Sleep: Circadian Rhythm, Sleep Pressure (02:43:02) Adenosine & Sleepiness (02:46:13) Tool: Growth Hormone & Deep Sleep (02:50:47) Cortisol & Circadian Rhythm, “Tired But Wired” (02:57:24) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer