Podcasts about energy metabolism

 Fatigue isn't just a side effect of modern life—it can be a sign of something far deeper. In this episode, Dr. Odell uncovers the complex world of Chronic Fatigue Syndrome and its surprising link to the powerhouses of our cells: the mitochondria. You'll discover how mitochondrial dysfunction may lie at the heart of the brain fog, muscle pain, and post-exertional crashes that define this debilitating condition. We explore the latest science behind energy production, how viruses and inflammation disrupt mitochondrial function, and why fatigue often lingers long after an illness. More importantly, we offer practical, evidence-based strategies for supporting your mitochondrial health—from targeted nutrients and antioxidants to lifestyle therapies and cutting-edge emerging treatments. Whether you live with chronic fatigue or are just curious about how your body makes—and loses—energy, this episode will transform the way you think about fatigue and healing.

 In this episode, we dive into the tiny but powerful molecule called NAD+ — the fuel your cells need to create energy, repair damage, and keep you feeling young and strong. As we age, NAD+ levels drop, and that can lead to low energy, slower healing, and more health problems. But here's the exciting part: science is showing that we can boost NAD+ through smart lifestyle habits and supplements — helping improve energy, brainpower, heart health, and even slow down aging. We'll break it all down in simple terms:  ✅ What NAD+ does in your body  ✅ Why it matters for your health and aging  ✅ How to naturally boost your NAD+ levels  ✅ What new research is saying about its future If you want to unlock more energy, sharper thinking, and better long-term health, this episode is for you! Tune in and learn how to help your body thrive — from the inside out.

In this episode of the Smarter Not Harder Podcast, Dr. Scott Sherr takes us on a solo deep dive into the myths, history, physiology, and media controversies surrounding methylene blue. From Blue Brains headlines to Huberman posts and clinical dosing strategies, Scott sets the record straight and unpacks why this molecule has become a lightning rod in health optimization conversations. Whether you're new to methylene blue or need clarity on the latest internet debates, this episode gives you science-backed context and a refreshingly clinical perspective. Join us as we delve into: The history of methylene blue as an antimicrobial and mitochondrial optimizer What methylene blue actually does inside your cells—and how it supports energy and detox A breakdown of viral headlines like “Blue Brains” and their flawed interpretations How Dr. Sherr uses methylene blue clinically and what most people get wrong about dosing This episode is for you if: You're hearing conflicting information about methylene blue and want clarity You want to understand how mitochondrial dysfunction impacts overall health You've wondered whether synthetic = bad (spoiler: not always) You want to know how to safely and effectively use methylene blue You can also find this episode on: YouTube: https://youtu.be/Nwe7Ap57u5Y Find more from Dr. Scott Sherr:Instagram: https://www.instagram.com/drscottsherr LinkedIn: https://www.linkedin.com/in/drsherr/ Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Get 10% Off your purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

Dr. Hoffman continues his conversation with Dr. Garth Nicolson, Founder, President, Chief Scientific Officer, and Emeritus Research Professor of Molecular Pathology at the Institute for Molecular Medicine in Huntington Beach, California, and Research Advisor for Nutritional Therapeutics, makers of NTFactor.

Unlocking the Power of Mitochondria: Dr. Garth Nicolson, a leading expert in molecular pathology, explores the critical role of mitochondria in energy production and overall health. His groundbreaking research reveals how repairing and restoring cell membranes improves health by increasing energy, decreasing fatigue, and slowing the aging process. The discussion delves into Dr. Nicolson's findings, including his influential fluid mosaic model of cell membrane structure. The focus then shifts to the importance of maintaining mitochondrial membrane integrity to combat aging and various age-related clinical conditions. Dr. Nicolson explains the benefits of membrane lipid replacement therapy using NT Factor Lipids to restore mitochondrial function, address fatigue, support recovery from chemotherapy, aid in chronic illnesses like fibromyalgia and long COVID, and assist in conditions such as schizophrenia, autism, and EMF sensitivity. The episode highlights the broad therapeutic potential of NT Factor Lipids, emphasizing their role in enhancing energy levels, promoting healing, and improving overall cellular health.

In this episode of The Art of Being Well, Dr. Will Cole sits down with Matt Maruca, founder & CEO of Ra Optics, to explore the powerful connection between light, mitochondria, and overall health. Matt shares his personal journey of overcoming chronic gut issues, allergies, and migraines by understanding circadian rhythms and the impact of blue light. They discuss why artificial light may be one of the biggest health disruptors of our time, the science behind light therapy, and practical ways to optimize your health through sunlight, meal timing, and blue light protection. For all links mentioned in this episode, visit www.drwillcole.com/podcast.Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:Head to Graza.co and use WILLCOLE to get 10% off of TRIO which includes Sizzle, Frizzle and Drizzle, and get to cookin' your next chef-quality meal.You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/WILLCOLE and using code WILLCOLE at check out. Go to lumen.me/WILLCOLE to get 20% off your Lumen.Visit www.neuromastersacadey.com to access a free masterclass on Neurohacking and start transforming your mind & as a result even your body today.Right now, you get an amazing 20% off, or if you choose their already discounted subscription, you get almost a third off the price! Only available when you visit my exclusive URL Puori.com/WILLCOLE and use my promo code WILLCOLE. Or save 20% off when you make a one-time purchase – still such great savings. Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

"Ketones Unlocked." In this episode, join host Chris Duffin as he delves into the fascinating world of ketones and their impact on metabolic health and performance optimization. Joined by guest experts Frank Llosa, founder and CEO of Ketone Aid, and Dr. Mike Debord, along with co-host Anthony Castor, they explore the biochemical magic of exogenous ketones in redefining energy, endurance, and mental clarity. Whether you're aiming for peak athletic performance, battling everyday brain fog, or seeking clarity in a chaotic world, this episode offers actionable insights into integrating these super fuels into your life. Get ready to redefine your relationship with energy and performance as the conversation unlocks the science and transformative potential of ketones.   Episode Highlights: Unlocking Energy and Clarity with Ketones: Join us as Chris Duffin and guests explore the biochemistry behind ketones, focusing on how these compounds redefine energy, endurance, and mental clarity. Frank Llosa, CEO of Ketone Aid, shares his expert insights on the power of exogenous ketones and their role in everyday life. Breaking Down the Science: Frank Llosa and Rahul Desai discuss what ketones are, how they function in the body, and the difference between endogenous and exogenous ketones. Learn how fasting and dietary adjustments can influence ketone production and the powerful benefits they bring. Beyond the Basics – Exploring Applications: Discover how ketones can be integrated into various lifestyle practices, from sports performance to cognitive enhancement and even aiding in overcoming substance dependency. Tips for Integrating Ketones into Your Life: Frank Llosa provides actionable strategies to effectively utilize ketones for diverse needs, whether that's preparing for a big race, enhancing recovery, or improving sleep. The Future of Ketones in Longevity and Health: The episode also touches upon the growing research surrounding ketones' role in longevity and maintaining cognitive function.   This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by: @marekhealth : Performance. Longevity. Optimization.

Ever feel bloated, exhausted, or like you're carrying extra weight—no matter how clean you eat or how much you work out? Your gut could be the real culprit behind your stubborn symptoms. In this solo episode, we dive deep into the gut-hormone connection and reveal:✅ Why bloating, fatigue, and weight gain are signs of poor gut health✅ How gut imbalances fuel estrogen dominance, cortisol spikes, and thyroid issues✅ Why probiotics and "gut-friendly" foods might be making things worse✅ The top hidden gut disruptors (stress, toxins, and more)✅ How to heal your gut for balanced hormones, better energy, and effortless weight lossIf you've been told “it's just stress” or “it's just your aging hormones” but still feel off—this episode is a must-listen. Tune in now to learn how fixing your gut could be the missing piece to feeling like yourself again!

The ProLongevity Podcast with Graham Phillips | Episode 38 In this episode, Graham & Dr Elena Gross discuss Migraine - Triggers, Symptoms and Management Chapterisation: 00:00 Introduction 00:50: Introduction to Migraine and Personal Journey 03:10 Understanding the Impact of Chronic Migraines 05:52 The Science Behind Migraine: Genetics and Environment 09:02 Mitochondria: The Powerhouses of Our Cells 11:54 The Complex Nature of Migraine Attacks 15:03 The Role of Energy Metabolism in Migraine 17:59 Migraine Symptoms and Phases Explained 21:01 The Importance of Rest and Recovery in Migraine Management 24:06 Conclusion: Hope and Future Directions for Migraine Treatment 36:45 The Evolutionary Perspective on Migraine 39:54 Understanding Migraine as a Protective Mechanism 43:32 The Connection Between Migraine and Epilepsy 46:46 Identifying Migraine Triggers 48:30 Four Pillars to Mastering Migraine 54:31 Introducing MigraKet: A New Supplement 01:05:01 The Future of MigraKet and Beyond This podcast video is brought to you by ProLongevity, the multi-award-winning lifestyle change program that helps reverse and prevent and reverse avoidable killer diseases like Type 2 Diabetes, Strokes, and Hypertension. Founder of ProLongevity, Graham Phillips discusses the latest controversial yet scientifically proven breakthroughs in understanding how to live healthy for longer. View a range of topics that will offer a new understanding that will help improve your health. From the damage caused to public health, by Big Food and Big Pharma that costs the UK and US Billions, why you can't just simply run off extra pounds by joining the gym, the connection between the brain and gut, why certain diets don't always work and can even damage your health. In each episode, you'll meet world-renowned experts who fully support ProLongevity. After watching, feel free to reach out to Graham Phillips with any questions or for any advice by contacting him here. Graham Phillips Links: website - https://www.prolongevity.co.uk/ X/Twitter - https://twitter.com/grahamsphillips Facebook -https://www.facebook.com/Prolongevity1 Instagram - https://www.instagram.com/prolongevity_ Dr Elena Gross Links website - https://www.drelenagross.com X/Twitter - https://twitter.com/DrElenaGross Facebook - https://www.facebook.com/DrElenaGross Instagram - https://www.instagram.com/DrElenaGross More info on MigraKet - Migraine Medical Food website - https://www.brainritual.com X/Twitter - https://twitter.com/migraket Facebook - https://www.facebook.com/migraket Instagram - https://www.instagram.com/migraket For more great videos like this, make sure you've subscribed. Or why not join our private members Facebook Group for future events and webinars, packed with news, debates, educational resources, free health risk assessments, and much more; https://www.facebook.com/groups/278916313071738/

Wondering why you have trouble falling asleep, why you hit that midday slump, how to reach peak performance, and more? Learn how to optimize your circadian rhythm with science journalist Lynne Peeples. In this conversation, Lynne and Liz discuss everything from light exposure to melatonin, as well as practical tips that everyone can use to improve their circadian rhythm and overall health. Your circadian rhythm is more important than you may realize, and everything from wildfire smoke to the types of windows in your home can affect it. Luckily, there are tweaks that everyone can make to their daily lives to get better sleep at night and feel more awake during the day. 0:23 What Is A Circadian Rhythm? 4:12 Light Exposure 7:16 Timing Your Meals For Better Metabolism 10:12 Benefits Of Optimizing Circadian Rhythms 13:10 Anti-Jetlag Protocol 18:21 Uses and Misuses of Melatonin 22:14 Blue Light Exposure 23:15 Unexpected Circadian Disruptors 34:30 Chronodiversity 37:31 How To Ditch Your Alarm 44:10 SAD Lamps 46:07 Daylight Savings Time & Circadian Rhythms 56:51 Fighting The 3 PM Slump 59:54 Optimizing Sleep For Shift Workers For more from Lynne, find her on Instagram at @lynne.peeples or online at www.lynnepeeples.com. Purchase her new book, The Inner Clock: Living in Sync with Our Circadian Rhythms where books are sold. Ready to uplevel every part of your life? Order Liz's book 100 Ways to Change Your Life: The Science of Leveling Up Health, Happiness, Relationships & Success now!  To join The Liz Moody Podcast Club Facebook group, go to www.facebook.com/groups/thelizmoodypodcast. Connect with Liz on Instagram @lizmoody or online at www.lizmoody.com. Subscribe to the substack by visiting https://lizmoody.substack.com/welcome If you like this episode, check out How To Hack Your Circadian Rhythm To Increase Energy, Sleep Better, Improve Gut Health, Fight Jet Lag & More With Dr. Russell Foster. This episode is sponsored by: LMNT: go to DrinkLMNT.com/LizMoody to get a free LMNT sample pack with any order. Puori: go to puori.com/LIZMOODY and use promo code LIZMOODY for 20% sitewide. Cymbiotika: use code LIZMOODY on cymbiotika.com to get 15% off plus free shipping on subscription orders. Pique: go to piquelife.com/LIZMOODY for 15% off plus a special gift. The Liz Moody Podcast cover art by Zack. The Liz Moody Podcast music by Alex Ruimy. Formerly the Healthier Together Podcast.  This podcast and website represents the opinions of Liz Moody and her guests to the show. The content here should not be taken as medical advice. The content here is for information purposes only, and because each person is so unique, please consult your healthcare professional for any medical questions. The Liz Moody Podcast Episode 287. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Professor Sergej Ostojic discusses the research and benefits of creatine supplementation. Sergej highlights that creatine is not only beneficial for exercise performance but also for brain health, liver health, and other conditions. He mentions that creatine deficiency can be a biomarker for certain health conditions. The discussion also covers the use of guanidinoacetic acid (GAA) as a precursor to creatine and its potential benefits and side effects.Check Out My Website For Coaching, Recommended Products and Much More:https://www.boostyourbiology.com/ Sergej's LinkedIn:https://rs.linkedin.com/in/sergej-m-ostojicChapters00:00 Introduction and Background of Professor Sergej Ostojic02:16 Creatine's Role in Energy Metabolism and Exercise Performance06:09 Creatine as a Biomarker for Health Conditions18:06 Exploring Guanidinoacetic Acid (GAA) as a Precursor to Creatine24:08 Overcoming Non-Response to Creatine26:52 The Anti-Aging Potential of Creatine31:33 Challenges in Assessing Mitochondrial Function38:32 The Role of Gut Microbiota in Creatine Metabolism41:24 Timing and Dosage Recommendations for Creatine Supplementation43:53 Exploring Synergistic Effects: Creatine and Coenzyme Q10Disclaimer:The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program. Hosted on Acast. See acast.com/privacy for more information.

Are you ready to go from barely surviving to thriving and have the knowledge and personalized support to change your health for good? Join me and Autumn Enloe from Autumn Enloe Nutrition as we discuss how blood sugars can affect our energy, metabolism and hormone health. Autumn is a Registered Dietitian who is passionate about helping women with a functional nutrition approach. She won't promote traditional dietary recommendations such as fearing fat or counting calories. She believes in nourishing your body with real, wholesome food that it's designed to run on WITHOUT restriction, breaking the bank, or spending hours in the kitchen. Autumn has been in the field for 14 years and has helped hundreds of women. She is based out of Stillwater, Minnesota but offers virtual one-on-one coaching, as well as customized testing for her clients. Connect with Autumn here:Website: https://autumnenloe.com/ 1:1 coaching program: https://autumnenloe.com/nutritioncoaching/Pre-order book:Amazon: https://amzn.to/3wslpvdTarget: https://bit.ly/3ULqkPM Instagram: https://www.instagram.com/autumn.enloe.nutrition/Facebook: https://www.facebook.com/autumnenloenutritionThank you so much for listening to the Mom2Mom Podcast! This podcast is meant to empower women and bring the community together through storytelling and education. Here, you will find encouragement, support and community. We are your community. And we're so happy to have you!Join the email list to be notified when episodes go live HERE! Please also make sure to comment, share and subscribe! xoxo, Stephanie Let's Connect:Website (how2mom.com) Instagram (@how2mom)Facebook (@how2mom)TikTok (@how.2.mom)Twitter (@how_2_mom)Linkedin (@how2mom)Pinterest (@how2mom)YouTube (@how2mom)

Today's episode we're breaking down why starting your day with a protein-packed breakfast will help you boost your energy, metabolism, strength, and body composition goals as a busy mamaWork With Me:https://mailchi.mp/chloepufftraining/privatecoachingBook a free discovery callhttps://chloepufftraining.as.meJoin the FREE Bold & Fit Motherhood Community: www.facebook.com/groups/chloepufftraining Connect with me on social media: Facebook: https://www.facebook.com/chloepuff Instagram: @chloepufftraining & @musclesmotherhoodmotivation Tik Tok: @chloepuff_training WWW.CHLOEPUFFTRAINING.COM

How To Naturally Deal with Iron Deficiency in Women | Functional Medicine Approach | Podcast #426 Schedule a FREE Consult: http://www.justinhealth.com/free-consultation Schedule with Rob @: https://www.heritagehealth.life Iron Panel: https://justinhealth.com/iron-test Description: Discover the power of functional medicine with our in-depth exploration of natural strategies to fight iron deficiency in women. This video unveils the often-overlooked connection between estrogen dominance and iron absorption issues, highlighting how hormonal imbalances can impact your health. We'll also delve into the challenges of maintaining adequate iron levels on a vegetarian diet and provide practical tips for nutrient-rich food choices. Additionally, we explore how poor digestion can hinder iron absorption and share functional medicine techniques to enhance digestive health. Our expert tips will help you understand and address the root causes of low iron, ensuring a holistic approach to your well-being. Tune in to transform your health with every view! #IronDeficiency #FunctionalMedicine #WomenHealth #EstrogenDominance #VegetarianDiet #NutritionTips #HolisticHealth #DigestiveWellness #NaturalRemedies #HealthAwareness ========================= Click here for Dr. J's links: https://www.justinhealth.com/links ========================= ***Click below to SUBSCRIBE for more Videos http://www.justinhealth.com/youtube ========================= Timestamp: [00:00] - Introduction to the Podcast and Iron Discussion [03:15] - Overview of Iron's Role in the Body and Energy Metabolism [13:20] - Different Types of Iron and Absorption Issues [23:45] - Importance of Co-Factors in Iron Absorption [35:10] - Testing for Iron Deficiency and Understanding Results [48:55] - Symptoms and Causes of Low Iron in Women [59:30] - Discussing Various Treatments and Interventions for Iron Deficiency [1:12:00] - Closing Remarks and Summary of Key Points

In this episode, we delve into intracellular NAD+ testing and explore self-experimentation aimed at optimizing NAD+ synthesis. From supporting the salvage pathway, de novo synthesis, and the Preiss-Handler pathway to inhibiting the CD38 enzyme, we will uncover some key nutrients and precursors that will enhance NAD+ stores and production. Topics: 1. Importance of NAD+ - Cellular processes involving NAD+ - NAD+ as a coenzyme for numerous enzymes - Focus on energy metabolism 2. Energy Metabolism and NAD+ - Glycolysis and NAD+ - Krebs cycle and NAD+ - Electron transport chain and ATP production 3. Disruption of NAD+ to NADH Ratio - Inhibition of electron transport chain - Role of reactive oxygen species (ROS) 4. Strategies to Restore NAD+ Levels - De novo synthesis pathway of NAD+ - Preiss-Handler Pathway - Salvage pathway - Supporting pathways with supplements - CD38 Enzyme inhibition: how and why? 5. Personal Experimentation and Results Sharing - Self-experimentation to optimize intracellular NAD+ - Reporting results of experimentation Thank you to our episode sponsor: ⁠Dr. Morse's Daily Detox Kit⁠ Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

A new 'Magic Bullet' that few people know about (including your doctor!) ... The importance of Methylene Blue and how it might transform human health particularly in areas of low oxygen delivery (fatigue states, depression and neurological damage).Check out the original recording with Dr Gonalez-Lima on https://deeprootsathome.com/methylene-blue-memory-mood-parkinsons-adhd/ (see the original on rumble linked from there).See more info on dosing on that websiteSee his latest summary paper on MB + photobiomodulation with neuro-inflammation here https://pubmed.ncbi.nlm.nih.gov/36203812/ He can also be found on various podcasts here https://www.ihmc.us/stemtalk/episode-107/00:00 Oldest known drug used for emergency room cyanide poisoning02:20 Electron Transport Chain in Mitochondria - how it produces cellular energy - a series of reduction/oxidation (redox) reactions where electrons are released - reduction is loss of hydrogen ions (protons) and gain of electrons05:20 What gets in the way? Cyanide poisoning and some virus infections like HIV or covid, causing low oxygen delivery and assimilation07:50 Long history of use as an anti-viral against Ebola/HIV and anti malarial.08:25 MB structure  - electrons held in a ring structure as a chromophore (like coloured foods). 10:20 Absorbs in IR range - molecule structure is auto-oxidant as well as electron cycling12:00 Hormesis and biphasic response operates in CFS/ME - at low doses it is advantageous at higher doses can be damaging14:00 Neurological benefits in healthy people at lower doses - slow aging, dementia, Parkinson's, as well as a powerful antidepressant , etc15:14 MB is off patent so not supported by Big pharma unlike anti-depressant drugs which are less and less effective - 'treatment resistant depression'17:30 High permeability as it passes the blood brain barrier and can optimise cellular respiration with well people. So enhances metabolic production enabling better healing, memory, aging i,e is a nootropic as well as a drug for acute medicine.21:00 Also upregulates (increases) gene expression of protein (enzyme) production longer term thus increasing capacity for oxygen metabolism22:00 CFS/ME is a form of metabolic 'poisoning' driven by emotional stress and toxicity23:20 Cure for bladder infections - becomes pro-oxidant in oxidative stress  especially important with the elderly26:40 Brain function and neurological issues must be coupled to haemodynamic response between oxygen and nitrous oxide in Complex 4 (cytochrome oxidase) facilitated by MB29:00 Enhancing mental function including extinguishing trauma memories and MB in memory reconsolidation30:20 Topical application using photobiomodulation of skin tumours with MB and IR light32:30 Disclaimer. Always contact your medical provider as there are some contraindications. However be aware most doctors are unaware of MB except in emergency situations. Please refer to Dr Gonzalez-Lima's papers to educate your doctor in low grad applications.33:50 Sources - please do your own research to find *If you're suffering from Chronic pain, fatigue or anxiety, I CAN HELP*CONTACT ME: https://www.alchemytherapies.co.uk/Alchemy Therapies & Emotional MasterclassOTHER USEFUL RESOURCESGroup Healing Program: http://myemotionalaudit.comAuthor/Book site: https//patriciaworby.comPodcast: https://www.alchemytherapies.co.uk/po...121 and group therapy and training for stress related conditions like anxiety, fatigue and pain: https://alchemytherapies.co.ukSee in particular: Thrive! - an introductory mindbody connection program and The Emotional Audit for more intensive training.COMING SOON:Intensive Training Program: https://emotionalmasterclass.com

In this week's episode of the Marathon Running Podcast, we delve into the intricacies of Energy Metabolism with Dr. Patrick Davitt, PhD, shedding light on crucial aspects that impact every runner's performance. We start by exploring the fundamental definition of Energy Metabolism and the role of ATP, the energy currency of our cells. Fueling takes center stage as we discuss its paramount importance during training runs, emphasizing the need to maintain blood glucose levels and supply energy to working muscles. The intriguing question arises: Can running in a "depleted" state, without eating before a run, actually benefit our body's adaptation? Dr. Davitt unravels the complexities of liver-stored glycogen versus muscle-stored glycogen,detailing the nuances of fuel partitioning, substrate metabolism, and the burning of carbohydrates or fats. The conversation extends to the adaptation of running in a fasted state or consuming slow-absorbing foods, exploring their impact on handling the later miles in a marathon. Dr. Davitt provides insights into the prevailing trend of fueling all runs and challenges the notion, pointing out that exceeding 60g of carbohydrates per hour lacks supporting data for performance improvement. As an endurance runner, understanding the ideal fueling strategy becomes crucial, with protein playing a role in replenishment and repair, and varying macronutrient ratios based on training versus competition. The podcast delves into the peculiar phenomenon of changing tastes in energy gels mid-run, linking it to hormonal changes and attempts at maintaining homeostasis. Dr. Davitt shares his extensive research on Ucan gels, presenting a study that tested superstarch cornstarch-derived gels against other formulations. The findings highlight the importance of consistency in maintaining stable glucose levels throughout a run. The episode concludes with an exploration of the "glycogen sparing myth" and strategies to prevent the dreaded bonk during a marathon. Listeners gain valuable insights from Dr. Patrick Davitt's seven years of unbiased research on Ucan, emphasizing his dedication to understanding the science behind energy metabolism and its practical implications for marathon runners.   Free UCAN sample pack: UCAN.co/mrpUse code MRP for 20% off!   Support our podcast and check out our RunSwag Tshirts ·       Our website: ⁠www.marathonrunningpodcast.com⁠ ·       Our Instagram: ⁠@runningpodcast⁠ ·       Our Amazon Storefront: ⁠Amazon Storefront⁠ ·       Join our Facebook group: ⁠SpeedStriders Facebook Group⁠ ·       Youtube https://www.youtube.com/@RunningPodcast

Energy, like food, needs to be metabolized to become refined enough to share with the world. Not only that... Without proper metabolism, we lose vital nourishment in the form of information and inspiration. This episode explores the organic process of energy metabolism and the most common ways energy is lost prior to completing its metabolic cycle.

In today's episode, we are diving into NAD+ and exploring how it is a critical component for breaking down fuel, such as glucose, and ultimately converting that fuel to ATP. We will explore various factors that deplete NAD+ or decrease the NAD+/NADH ratio as well as 6 proven strategies to increase NAD+ within the body. Lastly, we wrap up the episode with a conversation pertaining to the use of NAD+ therapy for CIRS/Biotoxin illness, specifically Mold Illness. Thanks so much for tuning it! Topics: 1. Understanding NAD+ and Its Role - Definition of NAD+ and NADH - Explanation of coenzymes in chemical reactions - NAD+ and NADH as coenzymes for electron transfer - Role in glucose metabolism and energy production - Importance of NAD+ for various cellular functions 2. Glycolysis and NAD+ - Illustration of glucose metabolism and insulin release - Role of GLUT4 transporters in glucose entry into cells - Introduction to glycolysis and its steps - Role of NAD+ as a coenzyme in glycolysis - Generation of NADH during glycolysis 3. TCA (Krebs) Cycle and NAD+ - Transition of pyruvate to acetyl-coA - Overview of the krebs cycle and its steps - NAD+ as a coenzyme in the krebs cycle - Accumulation of NADH during the cycle 4. Electron Transport Chain and NADH - Movement of pyruvate into the mitochondria - Role of NADH as an electron donor in the electron transport chain (ETC) - ATP production through the ETC 5. Factors Disrupting NAD+ Balance - Impact of toxins and pesticides on the ETC - Role of drugs, like NSAIDs, in inhibiting the ETC - Generation of reactive oxygen species (ROS) - Role of ROS in mitochondrial damage and NAD+ depletion - Link between NAD+ decline and aging 6. Consequences of NAD+ Depletion - Effect of NAD+ reduction on metabolism - Connection between NAD+ and metabolic diseases - Therapeutic potential of NAD+ in age-related diseases 7. 6 Strategies for NAD+ Restoration - Which supplemental NAD+ precursors are more effective - Inhibition of the CD38 enzyme using dietary nutrients - NAD+ IVs and patches: cost and quality - Intermittent fasting - Exercise and NAD+ - Other less well-known lifestyle factors that have a big impact on NAD+ 8. NAD+ Therapies to Support Recovery from Mold Illness - Link between NAD+ depletion and mold illness - Thoughts on and logic behind the use of NAD+ therapies for CIRS recovery Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit ⁠synthesisofwellness.com⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠linktr.ee/synthesisofwellness⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

I am thrilled to have Dr. Ana Andreazza, a distinguished professor at the University of Toronto, where she holds esteemed positions within the departments of Pharmacology and Toxicology, as well as Psychiatry. As the holder of a prestigious Canada Research Chair in Molecular Pharmacology of Mood Disorders, Dr. Andreazza's expertise delves into the intricate interplay between molecular pharmacology and mental health.At the forefront of groundbreaking research, Dr. Andreazza wears another significant hat as the Scientific Director of the Mitochondrial Innovation Initiative (Mito2i). Her remarkable contributions extend to the publication of over 150 research articles, garnering an impressive 9,000 citations. Dr. Andreazza's exceptional influence in the realm of mitochondrial research is particularly notable in its application to mental health, specifically mood disorders.Through her unwavering commitment to unraveling the mysteries of mitochondria and their profound impact on mental well-being, Dr. Andreazza's work revolves around comprehending how mitochondrial function intersects with neurotransmission. With an overarching focus on mood disorders, her efforts are dedicated to enhancing the lives of individuals grappling with these challenges.Join us in this enlightening episode as we delve into the world of mitochondrial research and its potential to transform our understanding of mental health, guided by the remarkable insights and expertise of Dr. Ana Andreazza.On this Episode: Introduction to Dr. Ana Andreazza2:40 Dr. Ana Andreazza's Exploration Through Mitochondria, Energy, and Mental Health8:18 Journey from studying Oxidative Stress to Redefining Mental Well-being18:17 Mitochondrial Health and Overall Well-Being26:28 Diverse origins of Psychiatric disorders 30:36 Dr. Ana's Vision for Mitochondrial Medicine and Mito2i38:57 The Vital Connection Between Ketones and Brain Health Show Links:Link to Dr. Ana Andreazza's website links: https://mito2i.ca My website is: Call to action for listeners: Follow ketones and Coffee Podcast on Instagram ( https://www.instagram.com/keton.esncoffee ), Youtube ( https://www.youtube.com/channel/UCsZZmBEenvZnU8tA1npAODA ), and Twitter ( https://twitter.com/KetonesP ) for updates and new episodes.~~~~~~Estrella by Audiorezout is licensed under a Attribution-NonCommercial-ShareAlike 4.0 International License.~~~~~~ Save yourself that trip to the market — Instacart delivers groceries in as fast as 1 hour! They connect you with Personal Shoppers in your area to shop and deliver groceries from your favorite stores.Instacart - Groceries delivered in as little as 1 hour. Free delivery on your first order over $35. Go to ketocoachlorenz.com and use the contact form to get your Free Consultation!Support the show

I am thrilled to have Dr. Ana Andreazza, a distinguished professor at the University of Toronto, where she holds esteemed positions within the departments of Pharmacology and Toxicology, as well as Psychiatry. As the holder of a prestigious Canada Research Chair in Molecular Pharmacology of Mood Disorders, Dr. Andreazza's expertise delves into the intricate interplay between molecular pharmacology and mental health.At the forefront of groundbreaking research, Dr. Andreazza wears another significant hat as the Scientific Director of the Mitochondrial Innovation Initiative (Mito2i). Her remarkable contributions extend to the publication of over 150 research articles, garnering an impressive 9,000 citations. Dr. Andreazza's exceptional influence in the realm of mitochondrial research is particularly notable in its application to mental health, specifically mood disorders.Through her unwavering commitment to unraveling the mysteries of mitochondria and their profound impact on mental well-being, Dr. Andreazza's work revolves around comprehending how mitochondrial function intersects with neurotransmission. With an overarching focus on mood disorders, her efforts are dedicated to enhancing the lives of individuals grappling with these challenges.Join us in this enlightening episode as we delve into the world of mitochondrial research and its potential to transform our understanding of mental health, guided by the remarkable insights and expertise of Dr. Ana Andreazza.On this Episode: Introduction to Dr. Ana Andreazza2:40 Dr. Ana Andreazza's Exploration Through Mitochondria, Energy, and Mental Health8:18 Journey from studying Oxidative Stress to Redefining Mental Well-being18:17 Mitochondrial Health and Overall Well-Being26:28 Diverse origins of Psychiatric disorders 30:36 Dr. Ana's Vision for Mitochondrial Medicine and Mito2i38:57 The Vital Connection Between Ketones and Brain Health Show Links:Link to Dr. Ana Andreazza's website links: https://mito2i.ca My website is: Call to action for listeners: Follow ketones and Coffee Podcast on Instagram ( https://www.instagram.com/keton.esncoffee ), Youtube ( https://www.youtube.com/channel/UCsZZmBEenvZnU8tA1npAODA ), and Twitter ( https://twitter.com/KetonesP ) for updates and new episodes.~~~~~~Estrella by Audiorezout is licensed under a Attribution-NonCommercial-ShareAlike 4.0 International License.~~~~~~ Save yourself that trip to the market — Instacart delivers groceries in as fast as 1 hour! They connect you with Personal Shoppers in your area to shop and deliver groceries from your favorite stores.Instacart - Groceries delivered in as little as 1 hour. Free delivery on your first order over $35. Go to ketocoachlorenz.com and use the contact form to get your Free Consultation!Support the show

Andrea Borghini is Associate Professor in the Philosophy Department at the University of Milan, Italy, and Director of Culinary Mind, an international center promoting philosophical thinking on food with a multi-disciplinary and cross-disciplinary approach. His research develops theoretical tools to rethink how we speak, structure, sense, and feel about food, eating, and culinary cultures.  Born and raised in two small towns of central Tuscany, he professionally trained and worked in New York City and the Boston area for over 15 years. His recent articles include:  ‘Seven Philosophical Questions About Recipes' (Bloomsbury, 2022);  ‘Cooking and Dining as Forms of Public Art' (Food, Culture, and Society, 2021, with Andrea Baldini); 'Hot Grapes: How to Locally Redesign Geographical Indications to Address the Impact of Climate Change' (with Nicola Piras and Beatrice Serini), World Development Sustainability, Volume 2 (2023); 'The Justice and Ontology of Gastrospaces' (with Matteo Bonotti, Nicola Piras, and Beatrice Serini), Ethical Theory and Moral Practice (2023). ‘Defective Food Concepts' (Synthese, 2021, with Nicola Piras and Beatrice Serini); ‘Eating Local: A Philosophical Toolbox' (Philosophical Quarterly, 2021, with Nicola Piras and Beatrice Serini); ‘From Obesity to Energy Metabolism. Ontological Perspectives on the Metrics of Human Bodies' (Topoi, 2021, with DavideSerpico); Andrea co-edited the collection of essays: A Philosophy of Recipes: Making, Experiencing, and Valuing (Bloomsbury, 2022, co-curated with Patrik Engisch). On this episode, Andrea joins host Mitchell Davis and discusses the philosophical implications of cooking, deriving meaning through food, and the question of who really owns a recipe. For more on Andrea, visit: https://sites.unimi.it/borghini/ and https://www.culinarymind.org/  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.12.548688v1?rss=1 Authors: Wang, S., Cheng, H., Li, M., Wu, H., Zhang, S., Gao, D., Huang, Y., Guo, K. Abstract: Although increasing studies has demonstrated that cell competition widely involved in the growth and homeostasis of multicellular organisms is closely linked to tumorigenesis and development, the mechanistic contributions to the association between tumor cell competition-driven heterogeneity and drug resistance remains ill-defined. In our study, lenvitinib-resistant hepatocellular carcinoma (HCC) cells display obviously competitive growth dominance against sensitive cells through reprogramming energy metabolism. Mechanistically, when BCL2 interacting protein3 (BNIP3) overexpression activates mitophagy activity in lenvatinib-resistant HCC cells, energy imbalance signal caused by reduced mitochondrial oxidative phosphorylation levels provokes the phosphorylation of AMP-activated protein kinase (AMPK) sensor; subsequently, enabled AMPK specifically targets enolase 2 (ENO2) to enhance glycolysis and eventually promots the competitive capacity and dominant growth. Of note, BNIP3 deficiency shows certain inhibition of cell competition outcome. Our findings emphasize a vital role for BNIP3-AMPK-ENO2 signaling in maintaining the competitive outcome of lenvitinib-resistant HCC cells via regulating energy metabolism; meanwhile this work recognaizes BNIP3 as a promising target to overcome HCC drug resistance. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

That was not an exaggeration. Everything. In this podcast I cover why riboflavin abolished my allergies, why a respiratory chain disorder could cause an autoimmune condition, and why a hypothetical athlete who went keto to take home the silver might be able to use thiamin to take home the gold. Most importantly, I cover why these are idiosyncratic needs, not general rules. The generalizable principle is that nothing is more central to life and health than energy. Read the written version with links here: https://chrismasterjohnphd.substack.com/p/energy-metabolism-governs-everything Get the methylation protocol here:  https://chrismasterjohnphd.substack.com/p/mthfr-protocol Check out my course on energy metabolism here: https://chrismasterjohnphd.substack.com/p/masterclass-with-masterjohn-energy

I veckans avsnitt pratar vi om tre olika studier:    Energy Expenditure of Adolescents During Overground Walking and Running   The Effects of Ground and Treadmill Running on Energy Metabolism and Muscle Contractile Properties: A Randomized Cross-Over Study   Caffeine Modifies the Immune and Anti-inflammatory Responses to Short Incremental Cycling Exercise Until Exhaustion in Humans: A Pilot Study   Mycket matnyttigt i detta avsnitt.   Tidsschema:    05:50 Studie nr 1: Löpning och gång, olika metabolism?  15:50 Studie nr 2: Vad förbrukar mest löpning utomhus eller på löpband?  26:02  Studie nr 3: Koffein till utmattning Mer poddar och artiklar hittar du på Prestera Mera   Värdar  Tommy Ivarsson, Fil.mag Biomedicin (M.Sc.)–Specialisering mot mänsklig prestation. tommy@umara.se   Simon Gustavsson, Fil.kand Biomedicin (B.Sc.)–Specialisering mot områdena kost och träning. simon@umara.se  

Good Idea BCAA sparkling water: https://www.goodidea.us/discount/JODELLE10 Promo code: JODELLE10 Eryn Knight, Vice President of GOOD IDEA has joined me today and we have a good idea to share with you that will be an easy fix to your blood sugar as well as a wealth of information as to the importance of building a better metabolism through blood sugar. You have some natural energy waiting to be harnessed, but it has to be harnessed by the right resources, and that's why I've invited back on Eryn Knight because she has a Good Idea she wants to enhance with! Thanks to our show sponsors: Buffalo Gal Shampoo & Conditioning Bar for Thinning Hair and Other Grass-Fed Beef Tallow products: https://tallowskincare.idevaffiliate.com/161.html use promo code: JODELLE for 15% off Spero EMF Protective gear: 15% off with this link! https://spero-protection-clothing-co.myshopify.com/jodelle Swanwick Sleep https://www.bn10strk.com/FITFOR10/ Promo code: FITFOR10 Purity coffee - my favorite coffee: https://puritycoffee.com/?rfsn=6403738.7488c or https://bit.ly/3oK8woT JODELLE10 to save 10% LIFEBLUD METHYLENE BLUE & Mag+ https://lifeblud.co/?ref=cGFWJ1 PROMO CODE: JODELLE

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.24.538169v1?rss=1 Authors: Onaolapo, A. Y., Okunola, O. B., Onaolapo, O. Abstract: Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Today I am joined by my friend Dr. Sarah Purcell. Sarah is an Assistant Professor at the University of British Columbia in Kelowna. Her research focuses primarily on metabolism and energy balance, and how various physiological, psychological and behavioural characteristics can impact appetite and energy requirements. We chat about: • How Sarah discovered her love for nutrition and her journey to becoming an assistant professor and researcher • What energy metabolism is: how much we burn and how much we need • Factors that contribute to appetite and energy expenditure • The "Calories in vs. Calories Out" concept and the dangers of being in a significant caloric deficit • Weight loss: how to approach it sustainably & how it plays a role in cancer treatment • Where to find FACTUAL nutrition information Sarah is a WEALTH of knowledge, and she is sure to spark some curiosity about what beliefs you currently have, and what may be true based on the nutrition research. If you want to hear more from Sarah, she will be presenting a Metabolism Masterclass in my Food & Body Freedom Course starting April 19th! This is going to be a life changing experience, and the most incredible investment you could make in yourself, for a future without food & body insecurities. Resources for you: • Learn more about the Food & Body Freedom Course to help support you on your intuitive eating journey:               https://www.bloombodycollective.com/food-freedom-course Connect With Sarah: Sarah's Instagram: @healthnut_sarah Sarah's email: sarah.purcell@ubc.ca Connect With Chelsea: • Chelsea's Instagram: @chelseaglubish • Bloombody Collective Website: https://www.bloombodycollective.com/ • Email: bloombodycolletive@gmail.com

This episode is brought to you by InsideTracker, Pendulum, and Levels. Today on The Dhru Purohit Podcast, Dhru sits down with Dr. Susanna Søberg to talk about her groundbreaking research on deliberate cold exposure and brown fat metabolism. Dhru and Dr. Søberg discuss the benefits of cold exposure for supporting mental and metabolic health as well as enhancing mood and energy in the short and long term. Dr. Susanna Søberg is one of the world's leading researchers and experts in cold and heat therapy and functional breathing. She is also the founder of the Soeberg Institute. Dr. Søberg obtained her PhD in metabolism at the University of Copenhagen. Dr. Søberg is the author of the international bestseller Winter Swimming, which has been translated into 13 languages. Her new book, Thermalist, is available in Danish and hopefully soon in English.In this episode, Dhru and Dr. Søberg dive into:-The short-term benefits of cold therapy (3:07)-How cold therapy boosts dopamine and norepinephrine levels for better mood and energy (6:14)-The long-term benefits of cold therapy (20:42)-The evolutionary history behind the benefits of cold exposure (23:59)-Brown fat's history and purpose and how to activate it (46:15)-Cold exposure improves insulin sensitivity (58:18)-Dr. Søberg's research watching winter swimmers in Denmark (1:10:26)-Psychological improvements for cold exposure (1:22:00)-Minimal viable dose for the benefits of cold exposure (1:37:00)-Cold showers and other means of cold exposure (1:39:14)-The research on heat exposure (1:57:21)-Future research on cold exposure (2:35:35)Also mentioned in this episode:-Winter Swimming-The Thermalist (in Danish)-The Soeberg Institute's course catalog (use code TRY THIS for 10% off)For more on Dr. Susanna Søberg, follow her on Instagram @susanna_soeberg, or through her website, https://www.soeberginstitute.com. InsideTracker provides detailed nutrition and lifestyle guidance based on your individual needs. Right now, they're offering my podcast community 20% off. Just go to https://www.insidetracker.com/DHRU to get your discount and try it out yourself.Pendulum is the first company to figure out how to harness the amazing benefits of Akkermansia in a probiotic capsule. To receive 20% off your first purchase of Pendulum's Akkermansia probiotic supplement, go to https://www.Pendulumlife.com and use code DHRU20.Levels is an app that pairs with continuous glucose monitors and sends real-time feedback straight to your phone. Right now, Levels is offering my listeners two free months of their Levels Membership. Head on over to https://www.levels.link/DHRU to learn more. Hosted on Acast. See acast.com/privacy for more information.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.23.529728v1?rss=1 Authors: Liu, H., Zhai, L., Liu, Y., Lu, D., VanderArk, A., Yang, T., Krawczyk, C. M. Abstract: Women experience osteoporosis at higher rates than men. Aside from hormones, the mechanisms driving sex-dependent bone mass regulation are not well-understood. Here, we demonstrate that the X-linked H3K4me2/3 demethylase KDM5C regulates sex-specific bone mass. Loss of KDM5C in hematopoietic stem cells or bone marrow monocytes (BMM) increases bone mass in female but not male mice. Mechanistically, loss of KDM5C impairs the bioenergetic metabolism resulting in impaired osteoclastogenesis. Treatment with the KDM5 inhibitor reduces osteoclastogenesis and energy metabolism of both female mice and human monocytes. Our report details a novel sex-dependent mechanism for bone homeostasis, connecting epigenetic regulation to osteoclast metabolism, and positions KDM5C as a target for future treatment of osteoporosis in women. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.21.529425v1?rss=1 Authors: Driesen, N. R., Herman, P., Rowland, M. A., Thompson, G., Qiu, M., He, G., Fineberg, S. K., Barron, D. S., Helgeson, L., Lacadie, C., Chow, R., Gueorguieva, R., Straun, T.-C., Krystal, J. H., Hyder, F. Abstract: Working memory (WM) is a crucial resource for temporary memory storage and the guiding of ongoing behavior. N-methyl-D-aspartate glutamate receptors (NMDARs) are thought to support the neural underpinnings of WM. Ketamine is an NMDAR antagonist that has cognitive and behavioral effects at subanesthetic doses. To shed light on subanesthetic ketamine effects on brain function, we employed a multimodal imaging design, combining gas-free calibrated functional magnetic resonance imaging (fMRI) measurement of oxidative metabolism (CMRO2), resting-state cortical functional connectivity assessed with fMRI, and WM-related fMRI. Healthy subjects participated in two scan sessions in a randomized, double-blind, placebo-controlled design. Ketamine increased CMRO2 and cerebral blood flow (CBF) in prefrontal cortex (PFC) and other cortical regions. However, resting-state cortical functional connectivity was not affected. Ketamine did not alter CBF-CMRO2 coupling brain-wide. Higher levels of basal CMRO2 were associated with lower task-related PFC activation and WM accuracy impairment under both saline and ketamine conditions. These observations suggest that CMRO2 and resting-state functional connectivity index distinct dimensions of neural activity. Ketamine's impairment of WM-related neural activity and performance appears to be related to its ability to produce cortical metabolic activation. This work illustrates the utility of direct measurement of CMRO2 via calibrated fMRI in studies of drugs that potentially affect neurovascular and neurometabolic coupling. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.02.526754v1?rss=1 Authors: Sharma, R. K., Chafik, A., Bertolin, G. Abstract: Cancer cells often hijack metabolic pathways to obtain the energy required to sustain their proliferation. Understanding the molecular mechanisms underlying cancer cell metabolism is key to fine-tune the metabolic preference of specific tumors, and potentially offer new therapeutic strategies. Here, we show that the pharmacological inhibition of mitochondrial Complex V delays the cell cycle by arresting breast cancer cell models in the G0/G1 phase. Under these conditions, the abundance of the multifunctional protein Aurora kinase A/AURKA is specifically lowered. We then demonstrate that AURKA directly interacts with the mitochondrial Complex V core subunits ATP5F1A and ATP5F1B. Altering the AURKA/ATPF1A/ATPF1B nexus is sufficient to trigger G0/G1 arrest, and this is accompanied by decreased glycolysis and mitochondrial respiration rates. Last, we discover that the roles of the AURKA/ATPF1A/ATPF1B nexus depend on the specific metabolic propensity of triple-negative breast cancer cell lines, where they correlate with cell fate. On one hand, the nexus induces G0/G1 arrest in cells relying on oxidative phosphorylation as the main source of energy. On the other hand, it allows to bypass cell cycle arrest and it triggers cell death in cells with a glycolytic metabolism. Altogether, we provide evidence that AURKA and mitochondrial Complex V subunits cooperate to maintain cell metabolism in breast cancer cells. Our work paves the way to novel anti-cancer therapies targeting the AURKA/ATPF1A/ATPF1B nexus to lower cancer cell metabolism and proliferation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

On today's episode of The Metabolic Link podcast, we're sitting down with Harvard Psychiatrist, Christopher Palmer, MD, to explore the common thread between brain energy metabolism and mental health. In this intimate interview, we dive into how Dr. Palmer became a pioneer in the field of metabolic psychiatry, the role of metabolic therapy in mental health and how its impacted the lives of his patients, and much more. Dr. Palmer is a psychiatrist and researcher working at the interface of metabolism and mental health who has been advocating the use of the medical ketogenic diet in the treatment of psychiatric disorders. This interview was recorded at Metabolic Health Summit in partnership with The Charlie Foundation in May of 2022.In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel, Apple, Google, Spotify, Amazon Music, and Buzzsprout.Thanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

One of the biggest realizations I've had over the past few years is that we are just NOT talking enough about perimenopause. It's that 5 to 15-year window of life where our bodies can really start to struggle with things like weight gain, extreme fatigue, insomnia, hot flashes ,migraines, anxiety, and more!  It feels like you got hit by a truck with no end in sight… Know what I mean? Catch today's show for a comprehensive look at perimenopause, as well as 7 simple lifestyle changes that could give you your best life back–and learn: The perimenopause puzzle Treatments to avoid  Signs and symptoms to look out for The best hacks for energy, metabolism, and brain power What to eat (and not to eat!)  7 ways to heal your hormones and feel GREAT Mentioned in this Episode:  NEW! Hormone Quiz – Check for imbalance and get personalized solutions!  Additional Resources: 8 Common Perimenopause Symptoms and How to Get Relief Naturally   #363: The Three Phases of Perimenopause and How to Navigate Each Phase with Grace Why Birth Control Pills Aren't Your Best Option in Perimenopause Top 5 Ways to Address Heavy Bleeding in Perimenopause

In this episode, we delve into the DUTCH Test.  What is it and how will it assist our energy and wellness? DUTCH stands for Dried Urine Test for Comprehensive Hormones.  This functional testing dives deeper into identifying imbalances and using nutrition and lifestyle to restore clients' health. Tune in to learn how to support your clients to build their energy levels, by encouraging patients to use these functional tests to identify imbalances. By using nutrition and lifestyle to restore your patients' health, you will empower your clients to achieve their health and wellness goals.    IN THIS EPISODE:     [03:00] Some doctors will test blood cortisol levels, usually in the morning. That doesn't give you an idea of how well cortisol levels are faring throughout the day.  [10:00] The DUTCH test website, and the videos to assist you to understand the benefits of taking the test.  [13:00] On the male side, we need to review the alpha reductase activity.  [16:00] The sex hormone report and methylation.  [22:00] Oxidative stress is tiring as the body spends a lot of liver energy to try to detox.  [24:00] Once you empower patients to use these tests, to restore their health the more success you'll have in your practice.     KEY TAKEAWAYS:    The DUTCH Test is beneficial as it has the advantage of the dried urine where you can measure the metabolites, and the cortisol awakening response allows us to see very precise measurements of when the cortisol's going up.      By digging deeper into each individual's health and by supporting the mitochondria, will further support your clients to build and maintain their energy levels.     Encouraging patients to use these functional tests to identify imbalances and using nutrition and lifestyle to restore their health, will empower your clients to achieve their health and wellness goals.     RESOURCES:    DUTCH Test Website    Strategies For Enhancing Energy Metabolism 

In this episode, we'll go over the best ways to determine whether our client's medications are impacting their energy levels.  Our special guest is Dr. Mihaela Gruita, a clinical pharmacist with extensive experience in hospital and research pharmacy. We'll discuss the fact that we're not trained as pharmacists, and we may not completely understand the impact of common medications and antibiotics on our client's energy. Tune in to learn how you can teach your clients to build their energy levels and support their mitochondrial function.    IN THIS EPISODE:   [03:00] Drug nutrient interactions and how they can impact energy production. [10:00] The side effects of beta blockers and tiredness in some clients. [13:00] Current resources to ascertain certain drug side effects. [16:00] The two things we should do with clients who are on a plethora of medications. [22:00] Mihaela's history and what prompted her to join the nutritional endocrinology program. [30:00] A new app for drug nutrient interaction via naturopathicpharmacist.com   KEY TAKEAWAYS:   Many drugs and medications may have side effects causing energy loss. We should review drug interactions to see how they affect the mitochondria and then assist people to replenish the nutrients via food. There are current and new resources to assess drug interactions including Mihaela's new app.   LINKS MENTIONED:    Dr. Mihaela Gruita's Website   Strategies For Enhancing Energy Metabolism   Get her free eBook on over-the-counter meds induced nutrient deficiencies @ www.drugnutrients.com   GUEST BIO:   Mihaela Gruita, PharmD, CFMP. Mihaela is a clinical pharmacist with extensive experience in hospital and research pharmacy. Over the years she began questioning the high amounts of drugs prescribed. She realized that few of the drugs were prescribed for the original symptoms and the rest were prescribed to cover side effects from the original few. Her focus is on medication-induced nutrient deficiencies, therefore she evaluates the patient's medication and supplement list to assess nutritional deficiencies, potential overdoses, drug-drug, supplement-supplement and drug-supplement interactions. Her ultimate approach is to find the root cause of their original problem. Toward this goal, she incorporates common and advanced lab evaluations, including genetic testing. Mihaela's education and training includes: • BS in pharmacological chemistry from UC San Diego • Doctor of Pharmacy from University of Southern California • Certified Functional Medicine Provider from Functional Medicine University • Certified Nutritional Endocrinology Practitioner from Institute of Nutritional Endocrinology • Certified in Medication Therapy Management and Diabetes Medication Therapy Management through the American Society of Hospital Pharmacists • Certified in Applied Pharmacogenomics through American College of Clinical Pharmacists

Former coworker and good friend Sean joins us to discuss his fitness background including research in Energy Metabolism and Muscle Biophysics! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Nick talks to Dr. Martin Picard, a biologist at Columbia University whose lab studies mitochondrial psychobiology, linking together molecular processes within mitochondria with human experience. They discussed; what mitochondria are and where they came from: their role in energy & metabolism; the mitochondrial genome; the importance of mitochondria in stress & aging; how exercise, diet, and genetics influence mitochondria biology; hair graying and whether it's reversible; the mind-mitochondria connection.USEFUL LINKSSign up for the weekly Mind & Matter newsletter[https://mindandmatter.substack.com/?sort=top]Follow Nick's work through Linktree:[https://linktr.ee/trikomes]Elysium Health, a life sciences company focused on aging research. Use code MIND for 10% off first purchase of any of their supplement products. Valid until 6/22/2022.[https://www.elysiumhealth.com/discount/MIND]DoubleBlind Magazine, a leading source of news, information, and education about psychedelics. Use code MINDMATTER for 20% site-wide. [https://www.doubleblindmag.com/mindmatter]Athletic Greens, comprehensive daily nutrition (Free 1-year supply Vitamin D w/ purchase)[https://www.athleticgreens.com/mindandmatter]Organize your digital highlights & notes w/ Readwise (2 months free w/ sub)[https://readwise.io/nickjikomes/]Download the podcast & follow Nick at his website[https://www.nickjikomes.com]Try Levels Health to monitor your blood sugar & optimize your diet[https://www.levelshealth.com/join?partner=MINDANDMATTER]Support the show

สรุปงานวิจัย “The energy balance model of obesity: beyond calories in, calories out” Kevin D Hall, I Sadaf Farooqi, Jeffery M Friedman, Samuel Klein, Ruth J F Loos, David J Mangelsdorf, Stephen O'Rahilly, Eric Ravussin, Leanne M Redman, Donna H Ryan, John R Speakman, Deirdre K Tobias ตีพิมพ์ใน : The American Journal of Clinical Nutrition วันที่ตีพิมพ์ : 4 กุมภาพันธ์ 2565

มาทำความเข้าใจ 3 เรื่องสำคัญ 1. Fat burn = Actual Fat loss?? 2. คาร์โบไฮเดรตสำคัญต่อร่างกายอย่างไร แบบที่ไขมันทำไม่ได้ 3. อินซูลินหรืออะไรกันแน่ที่ทำให้อ้วน??

If you're starting to feel the effects of aging—weight gain, loss of energy or mental clarity, irritability, and even loss of libido—you'll want to tune in for today's expert, Dr. Christopher Asandra. Dr. Asandra is a revered physician based in Beverly Hills, focusing on hormone replacement therapy and other anti-aging treatments.  Countless men and women worldwide have benefited from his cutting-edge therapies, achieving their own optimal health, balance, and vitality.  In today's episode, you'll learn: How our hormones change as we age What Bioidentical Hormone Replacement Therapy (HRT) is—and how it's evolved over the last decade How to know if you're a candidate for HRT What benefits you can expect from HRT Natural methods to boost declining hormones  Learn More: asandramd.com Instagram: @asandramd Sponsored by Kayo Body Care www.KayoBodyCare.com Use Code KISS20 20% Off first purchase Questions? Text Christine at 1-310-361-8697

ANNOUNCEMENT! Dissolve-It-All - breaking down scar tissue, inflammation and calcification PUFA Protect - Eliminating a lifetime of a high PUFA diet Use discount code EHR15! Today we had Josh Rubin on the show from East West Healing. We were going to have his wife Jeanne on the show as well but there was a scheduling conflict, so we'll have her on next time! I really like Josh's approach to healing and removing the stress on the body through proper sleep, lifestyle, sugar and more. After talking to him I could tell that they're really putting all the pieces of health together. There's more to health than just food. Because the body is always healing and returning to homeostasis, it's our job to simply remove the things that are preventing that from happening. On Last Thing! As always your support via your donations and bookmarking our Amazon link to use each time you purchase is how we keep our show going. Thank you for bookmarking our Amazon link even if you're not buying anything right now! :) Thank you all! Sponsors For This Episode: Extreme Health Academy Use code EHR14 for a free 2 week trial! Greenwave Dirty Electricity Filters Relax FAR Infrared Sauna Colostrum Joovv Red Light Therapy Featured Products For This Episode: Bellicon Rebounders Aloe Vera Blue Blockers Rapid Release Technology Pro 2 Barf World Raw Dog Food The Biomat Chemical Free Organic Skincare! Activation Products - Ocean's Alive & Magnesium Show Guest: Josh Rubin Guest Info Josh has a Bachelors in Occupational Therapy, studied TCM for 3 years and is almost done with his 5th year at Canadian College of Osteopathy. He is a CHEK Level 4, HCL 3, CNMT, RCP and CN. Jeanne is a Certified Clinical Nutritionist, CHEK 2, HLC 3, RCP and skilled Biodynamic Craniosacral Therapist. Show Topic: Pro metabolic diet, Energy, ATP, mitochondria, thyroid, hormones Guest Website(s): http://www.eastwesthealing Please Support Us If You Are Able: (Opens in a new window - Every bit helps us to keep delivering even better shows that help you heal & thrive!) [spp-transcript]

More information about this and other health topics can be found in my books "Low Dose Medicine" and "Cure Without Side effects" by following these links: ►►►https://amzn.to/3Bbx8fd ►►►https://amzn.to/36iaqDU To check the Low dose Medicine health kit follow this link: ►►►https://kit.co/cureswithoutsideffect/low-dose-medicine This episode is also available as a blog post: https://cureswithoutsideffects.wordpress.com/2021/11/12/cytokines-series-interleukin-10-the-master-anti-inflammatory-cytokine/ DISCLAIMER: Nothing contained in this video is intended nor can be taken to diagnose, treat, or cure any disease. It is for informational purposes only. This episode is also available as a blog post: https://cureswithoutsideffects.wordpress.com/2021/07/14/energy-metabolism-and-the-citric-acid-cycle-catalysts/ --- Send in a voice message: https://anchor.fm/cureswithoutsideeffects/message

Guests: Dr. Paul Kononoff, University of Nebraska-Lincoln and Dr. Logan Morris, Perdue AgriBusiness. Co-host is Dr. Clay Zimmerman.As we move into the fall and new silage is going into the bunkers, we wanted to take a closer look at energy metabolism and the mechanics of feed efficiency. Let's talk about heat production and metabolism. Dr. Paul Kononoff joined us for a webinar on August 4th, 2021, to review the basics of energetics and new science that will help feed cows better. If you want to watch the webinar, go to Balchem.com/realscience.To kick things off, Dr. Paul Kononoff answers Scott's question about how our understanding of energetics changed over the last 60 years. He explained the animals have changed dramatically as well as how we view energy when it is supplied to the cows. Feed characterization has changed since the sixties as well as NRC requirements of dairy cattle and how we measure it. (7:00) Dr. Logan Morris discussed their study on factors that influence heat production. They found the two biggest factors were dry matter and body weight. Bodyweight represents the maintenance energy expenditure, which keeps the cow alive and functioning. Dry matter intake drives the rest of heat production. Higher dietary protein leads to more heat production and generates more milk protein which leads to more heat production. (15:04)Dr. Logan Morris discusses the change in the industry over the past four or five years and how producers now face production caps and quota systems. He discussed his research on starch and fat and how higher starch increased milk yield. To produce a concentrated product for lowest milk volume, with maximum components, the study suggested feeding a lower dietary starch to prevent an increase in milk yield. (28:56)Dr. Paul Kononoff discussed the effect energy mobilization of tissue has on feed efficiency. When looking at dairy cattle there are different physiological stages, different ages and different lactation stages. Feed efficiency can be extremely valuable and a useful proxy but can be misleading so you have to understand the conditions around it. (34:46)Dr. Logan Morris discusses his research that shows starch and fat act differently when influencing milk protein production. (49:43)Dr. Paul Kononoff is also participating in the new NRC release. You can view the five-webinar series from Balchem on the NRC at Balchem.com/RealScience.If you want one of our new Real Science Exchange t-shirts, make sure to screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll get a shirt in the mail to you.Please subscribe and share with your industry friends to bring more people to join us around the Real Science Exchange virtual pub table.This podcast is sponsored by Balchem Animal Nutrition and Health.

Understanding why we have no energy. We discuss how inflammation steals from your energy, the problem with lectins, the truth on fiber, and energy metabolism. As well as, the microbiome, metabolic flexibility, insulin resistance, and the biggest energy disrupters.  Thank you to our sponsors: Athletic Greens - athleticgreens.com/stephanieOrion Red Light Therapy - Use promo code STEPHANIE10 for 10% off - https://www.orionrlt.ca/?ref=StephanieLumen - Use promo code DRSTEPHANIE25 for $25 Dollars off - https://www.lumen.me/LMNT Electrolytes - FREE 7 flavor sample pack at http://drinklmnt.com/DrEstimaPRIMADINE - Code DRSTEPHANIE10 for 10% off -https://oxfordhealthspan.com/discount/DRSTEPHANIE10Ancestral Supplements - Use Promo code ASA10 takes 10% off any purchase - https://ancestral-supplements.myshopify.com/?rfsn=5900205.652074&utm_source=refersion&utm_medium=affiliate&utm_campaign=5900205.652074Some of the links above are affiliate links. Making a purchase through these links won't cost you anything (and in many cases give you a discount), but we will receive a small commission. This is an easy, free way of supporting the podcast. Thank you! Social: https://www.instagram.com/dr.stephanie.estimahttps://www.facebook.com/groups/betterwithdrstephanie Membership Site:https://hellobetty.club/ Episode Overview: 12:56 Dr. Gundry's Origin Story23:05 Why We Have No Energy26:49 Inflammation Is An Energy Vampire31:45 The Problem With Lectins34:36 Lipopolysaccharides37:31 The Truth On Fiber43:27 Gas and Microbiome48:14 Mitochondria53:24 Metabolic Flexibility56:54 Insulin Resistance1:04:53 Some Of The Biggest Energy Disruptors Betty Hormones Sign-up: https://hellobetty.club/betty-hormones/More information about the book at The Betty Body Book Join the Betty Booty ChallengeJoin the Hello Betty Community here! 

More information about this and other health topics can be found in my books "Low Dose Medicine" and "Cure Without Side effects" by following these links: ►►►https://amzn.to/3Bbx8fd ►►►https://amzn.to/36iaqDU To check the Low dose Medicine health kit follow this link: ►►►https://kit.co/cureswithoutsideffect/low-dose-medicine This episode is also available as a blog post: https://cureswithoutsideffects.wordpress.com/2017/10/03/migraine-and-headaches/ DISCLAIMER: Nothing contained in this audio is intended nor can be taken to diagnose, treat, or cure any disease. It is for informational purposes only. This episode is also available as a blog post: https://cureswithoutsideffects.wordpress.com/2017/10/02/detoxification-drainage-and-energy-metabolism/ --- Send in a voice message: https://anchor.fm/cureswithoutsideeffects/message

Understanding the changes in the brain before, during, and after menopause. Discussing the structural and metabolic changes that happen during menopause. As well as what you can do to protect your brain.  Referenced Article - https://www.nature.com/articles/s41598-021-90084-y.pdf Chronic Cardio - https://better-with-dr-stephanie.simplecast.com/episodes/geeky-magic-chronic-cardio-PfBmncuA Thank you to our sponsors: Athletic Greens - athleticgreens.com/stephanieOrion Red Light Therapy - Use promo code STEPHANIE10 for 10% off - https://www.orionrlt.ca/?ref=Stephanie Episode Overview: 0:30 Introduction5:12 Discussing The Paper8:12 Structural Changes10:48 Metabolic Changes12:45 Grey Matter Volume17:14 White Matter Volume18:30 Energy Metabolism20:30 Brain Health22:36 Methods for BDNF Growth - Fasting, Sleep, Ketosis24:00 Metabolic Health and Ketogenic Diet26:17 Keto Flu28:58 What Can You Do? Social: https://www.instagram.com/dr.stephanie.estimahttps://www.facebook.com/groups/betterwithdrstephanie Membership Site:https://hellobetty.club/ More information about the book at The Betty Body Book Join the Betty Booty ChallengeJoin the Hello Betty Community here! 

For the most part, the brain relies on glucose as its main energy source. In fact, we say the brain preferentially uses glucose. In times of low glucose levels such as fasting or starvation, the brain can use ketones, lactate, and amino acids (worth noting: the brain does not use fatty acids to generate energy). Circulating glucose molecules are recruited into neurons via GLUT transporters (specifically GLUT3 on neuronal cell membranes). Neuronal hexokinase phosphorylates the glucose to form glucose-6-phosphate. This phosphorylation prevents the glucose molecules from leaving the cell. The inward glucose gradient is maintained, and the molecule is committed to an energy-producing pathway. Glucose-6-phosphate can be processed via a handful of pathways in the brain, including glycolysis, the pentose phosphate pathway, and glycogenesis. The first two of these pathways occur in the neurons. Glycogenesis only happens in the brain astrocytes. After listening to this AudioBrick, you should be able to: List and briefly describe the major pathways for energy metabolism in the brain, and explain the role of astrocytes in these pathways. Describe the role of glycogen in brain metabolism and the regulation of this process. Explain the mechanism and function of the lactate shuttle. Describe how metabolism is altered in pathological conditions (including hypoxia, ischemia, hypoglycemia, and depression). You can also check out the original brick on Brain Energy Metabolism from our Neurology and Special Senses collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com You will get 5 days of full access to our Rx360+ program, including nearly 800 Rx Bricks.  After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology. *** If you enjoyed this episode, we'd love for you to leave a review on Apple Podcasts.  It helps with our visibility, and the more med students (or future med students) listen to the podcast, the more we can provide to the future physicians of the world. Follow USMLE-Rx at: Facebook: www.facebook.com/usmlerx Blog: www.firstaidteam.com Twitter: https://twitter.com/firstaidteam Instagram: https://www.instagram.com/firstaidteam/ YouTube: www.youtube.com/USMLERX Learn how you can access over 150 of our bricks for FREE: https://usmlerx.wpengine.com/free-bricks/ from our Musculoskeletal, Skin, and Connective Tissue collection, which is available for free. Learn more about Rx Bricks by signing up for a free USMLE-Rx account: www.usmle-rx.com You will get 5 days of full access to our Rx360+ program, including nearly 800 Rx Bricks.  After the 5-day period, you will still be able to access over 150 free bricks, including the entire collections for General Microbiology and Cellular and Molecular Biology.

In this episode, I'm joined by Josh and Jeanne from East West Healing. Josh has a Bachelors in Occupational Therapy, studied TCM for 3 years and is almost done with his 5th year at Canadien College of Osteopathy. He is a CHEK Level 4, HCL 3, CNMT, and CN. Jeanne is a Certified Nutritionist, CHEK 2, HLC 3 and skilled BioDynamic Therapist. They have spent the last 20 years not only educating themselves through self research, courses and certifications, but also working 1:1 clients all over the world. We chat about: their different upbringings + how it affected their outlook on nutrition how they landed in the metabolism sphere why it's important to get vitamins + minerals from food rather than supplements the role that the thyroid plays in our bodily functions You can find more information about Josh and Jeanne on their website, or by reaching out directly via email!

Question: Can protein replete glycogen on a low-carb diet?Yes, it's possible. And I don't know exactly what the dosing is, but I think it's totally possible. It comes at the risk, I don't want to say risk, but at the downside of creating a lot more ammonia. But I think it's quite possible. I think it was Master Nutrition, Energy Metabolism, Lesson 17, it was the one on the evidence around low-carb and athletic performance. And if you look at the studies suggesting low-carb does not compromise athletic performance, the diets are much higher protein than the diets that suggest that it does compromise athletic performance for glycogen levels. And so, I think on a low-carb diet protein is going to probably be a very critical determinant of glycogen levels.If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. For the remainder of 2020, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.