Podcasts about Lactate

After 40, building and keeping muscle gets harder, joints take longer to recover, and the training volume that used to work starts costing more than it returns.I sit down with Jesse Salas, movement coach and Foundation Training specialist, and Steve Munatones, co-creator of KAATSU Global, to break down how KAATSU actually works, who it's for, and how to use it to build muscle, support recovery, and extend the years you stay physically capable.What we explore:- How blood flow restriction training builds muscle with less load and less joint stress, especially after 40.- Why vascular health is trainable, and how daily KAATSU use improves circulation, recovery, and energy over time.- What the 12-minute post-KAATSU growth hormone window is and how to use it for performance or physical therapy.- How KAATSU supports nervous system recovery and why it's being used for stress, sleep, and PTSD protocols.- Who KAATSU is actually for: aging adults, injured athletes, sedentary beginners, and everyone in between.Chapters:00:00 Intro 03:48 KAATSU Origins: Dr. Sato and the Aging Population 07:37 How Blood Flow Restriction Actually Works 09:32 Muscle Quality vs. Heavy Lifting 13:19 Daily KAATSU Use and Cumulative Benefits 17:29 Lactate, Healing Hormones, and Pain Relief 20:16 Steve's 13 Years Training Under Dr. Sato 25:20 KAATSU for Weight Loss and Pre-Diabetes 49:50 KAATSU and Barbell Training: Strength Protocols 57:22 Vascular Elasticity and Metabolic Longevity 01:05:14 The 12-Minute Growth Hormone Window 01:08:56 Nervous System Recovery: PTSD and Stress 01:13:09 Habit Design: Getting the Bands On Daily 01:40:48 Hydration and Fueling for KAATSU Training 01:47:25 Core, Posture, and Foundation Training 01:48:57 How to Get Started with KAATSUAbout Jesse Salas:Movement coach, former firefighter, and Foundation Training specialist. Jesse integrates KAATSU with breathwork and movement fundamentals to help athletes and everyday people train smarter, recover faster, and stay injury-free.Instagram: https://www.instagram.com/coachsalas/About Steve Munatones:Co-founder of KAATSU Global and the person who brought Dr. Yoshiaki Sato's research from Japan to the world. After 13 years of direct training under Dr. Sato, Munatones has applied the technology across Olympic athletes, rehab patients, and aging populations on every level.Website: https://www.kaatsu.com/Instagram: https://www.instagram.com/kaatsu_global/–This episode is sponsored by:AX3: Clean supplements, real standards.

The cause and cure for feeling low in energy during racing. A 5k race burns only about 350 calories. Timestamps 00:45 Mid-race low energy Most rowers think they've run out of energy half way through a race. Most races aren't energy-depletion events (porridge is 350 calories; banana is 95 calories). You likely aren't running out of fuel. 02:00 The misconception The feeling of distress in sprint racing comes in two places - about 40 seconds after the start and again just after the midway point. It feels like exhaustion but your body uses the same "alarm signal" for multiple problems. Believing you're out of energy gives you mental permission to slow down. But you haven't yet earned the right to slow down. 03:00 What's actually happening? Lactate - that burn feeling is your body accumulating lactate faster than your body can clear it. It's a signal that you are working really hard. Not that you're out of energy. Pacing and mental focus can help you get beyond that feeling of pain. Rebecca and her doubles partner adjusted their race plan to give a focus at the point the pain kicked in. 04:45 What to do at mid-race Do not back off on your rate and pressure. That instinct is probably wrong. You have fuel - you have to let lactate clearance catch up with output. A fractional reduction in output can allow lactate clearance to get ahead. - breathing - if it's chaotic - focus breathing out at the finish for 3 strokes. To stabilise your breathing - pressure - if something has to give, let the pressure drop fractionally. Hold the rate if you can (it's harder to rebuild than pressure). Make a 1% change in your pressure. - check your legs are still driving and you're using the right technique Practice the 1% drop in pressure in training. Push for 10 strokes - power strokes; then do another 10 strokes dropping the pressure 1% and keeping the rate the same; then do a third 10 strokes back onto full pressure. It's a tiny step down and then a deliberate step up. You can repeat this set of 30 again if you need. The mental reframing is necessary as well. Tell yourself "this is lactate" and I have got fuel to continue. Once you know what it feels like you can choose your response.

The World Cup is here, and while we watch some of the world's greatest athletes competing on a global stage, it's fascinating to consider what effect this intense activity may have on the human body. With that in mind, we're re-releasing our conversation with Stanford biochemist Jonathan Long on the future of exercise. Jonathan studies the chemistry of what happens inside your body when you move, and his findings are pointing toward some genuinely surprising possibilities — including treatments for obesity, diabetes, and even, someday, an exercise pill. If the athleticism on the pitch has you feeling inspired, this one is well worth another listen. Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu. Episode Reference Links: Stanford Profile: Jonathan Long Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / Facebook Chapters: (00:00:00) Introduction Russ Altman introduces guest Jonathan Long, a professor of pathology from Stanford University. (00:02:02) Effective Weight Loss Drugs The history and development of GLP-1 receptor agonists. (00:04:04) Understanding Metabolism and Exercise Why Long's lab starts with molecules to understand metabolism and physical activity. (00:05:10) Animal Models in Exercise Studies The use of animal models in exercise studies and the discovery of Lac-Phe. (00:06:47) Psychological Preparation for Exercise The psychological aspects of exercise and the involvement of endocannabinoids in exercise motivation. (00:09:00) Lac-Phe's Role and Mechanism The role of Lac-Phe and its production in the gut. (00:12:08) Differences in Exercise Response Differences in exercise response between trained athletes and untrained individuals. (00:12:57) Diabetes and Metabolic Diseases The relationship between diabetes, exercise, and metabolic diseases. (00:15:01) Lac-Phe as a Potential Therapeutic The potential of Lac-Phe as a weight loss drug, and parallels to GLP-1 drug development. (00:16:21) Importance of How Weight is Lost Whether the method of weight loss matters, and the importance of preserving lean muscle mass. (00:18:37) Exercise as Medicine The concept of exercise as medicine, and defining physical activity at the same resolution as modern medicines. (00:22:11) Metformin and Exercise Pathways The unexpected connection between metformin and the Lac-Phe pathway. (00:24:01) Prospects of an Exercise Pill The future of an exercise pill, and the challenges associated with its development. (00:27:05) Conclusion Final thoughts on the future of exercise. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

For decades, lactate was viewed as a waste product associated with fatigue and declining performance. Today, a growing body of research paints a very different picture.In this episode, sports scientist and researcher Aitor Viribay Morales explores the evolving science of lactate, from its role as a critical fuel source to its emerging importance as a signaling molecule that influences performance, recovery, and adaptation.The conversation dives into the lactate shuttle theory, the relationship between lactate and endurance performance, the interaction between lactate and the nervous system, and the growing interest in exogenous lactate as a potential tool for athletes. Aitor also shares insights from his work in exercise metabolism and sports nutrition, highlighting how our understanding of lactate continues to evolve beyond traditional models of fatigue.Whether you're a coach, athlete, researcher, or endurance enthusiast, this episode offers a fascinating look at one of the most misunderstood molecules in sports science.Interested in learning more about the latest developments in endurance performance and sports science? Subscribe to the HIIT Science email list for updates on new research, courses, and educational opportunities.Today's speakers:Prof Paul Laursen https://www.paullaursen.com/Dr Aitor Viribay Morales: https://www.linkedin.com/in/aitor-viribay-598336155https://glut4science.com/

Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients.

This week we speak with 2 pioneers in the field of pediatric cardiac critical care, Dr. Anthony Rossi and Dr. Gil Wernovsky. Both were present at the very start of the field of cardiac critical care for children. What was it like in an era before transesophageal echocardiography or even postoperative echo? Why was the advent of the bidirectional cavo-pulmonary anastomosis such a game changer in the care of children with heart disease? What do Drs. Rossi and Wernovsky think were the most important improvements to care for children with heart disease in their 35+ year careers? What about care today troubles these intensive care gurus? This is a rare opportunity to speak with two who have seen and done it all in cardiac critical care for children.For those interested to hear Dr. Rossi speak about goal directed therapy, take a listen to episode 21 and episode 200 of this podcast!

In this episode of the Flex Diet Podcast, I sit down with Dr. Nathan Jenkins to discuss how to improve performance, body composition, and long-term health through the lens of aerobic development and metabolic flexibility. Nathan shares his journey from exercise physiology and coaching CrossFit athletes to his new role teaching physiology at the University of Georgia School of Medicine. We discuss why metabolic flexibility is such a powerful framework for understanding everything from biochemistry and exercise performance to metabolic disease. We also dive into interpreting maximal exercise testing data, including VO₂ measurements, EKG analysis, and near-infrared spectroscopy (NIRS), along with how different energy systems work together during training and competition. Nathan explains why building an aerobic base is critical for repeated high-intensity performance, how pacing impacts outcomes, and why the ability to "suffer" is actually a trainable skill. To wrap up, we cover practical strategies you can apply right away, including prioritizing protein and carbohydrates, improving sleep quality, and addressing common micronutrient deficiencies through blood work, such as magnesium, vitamin D, and omega-3 status. Sponsors: Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8 Available now: Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here. Episode chapters: 02:47 Meet Dr Nathan Jenkins 04:38 CrossFit Nutrition Reality Check 07:09 Leaving Tenure for Family 09:21 Back to Academia and Med Ed 11:29 Why Exercise Physiology Matters 14:36 Stress Tests Reveal Pathology 18:19 Max Testing and NIRS Setup 22:42 Raw Data Over Machine Outputs 24:18 Bohr Effect and Oxygen Delivery 28:09 Energy Systems in the Real World 33:05 Coaching Basics That Matter 35:40 Teaching Cardio From First Principles 36:36 Aerobic Base Reality Check 37:19 Cardio for Meatheads Pitch 39:13 CrossFit Endurance Breakthroughs 41:49 Fixing Time Domain Weakness 45:46 Pacing Like Froning Fraser 48:42 RAAM Gamesmanship Story 51:45 Pain Management Truths 53:23 VO2 Max Feels the Same 55:54 Suffering as a Skill 59:09 Cold Plunge Mindset Study 01:00:52 Caffeine Placebo and Belief 01:03:22 Heat Acclimation and 10K Prep 01:04:36 Metabolic Flexibility Lens 01:08:16 Teaching Diabetes Integration 01:10:56 Bloodwork Meets Flexibility 01:12:37 Where Fat Goes Wrong 01:15:07 Sustainable Deficit Strategy 01:16:34 Four Priorities Blueprint 01:17:21 Protein and Carb Targets 01:21:08 Sleep and Micronutrients 01:27:06 Omega-3 Testing Nuance 01:29:36 Wrap Up and Next Steps 01:31:52 Newsletter and Flex Diet Cert 01:33:20 Final Thanks and Subscribe Flex Diet Podcasts you may enjoy: Episode 344: Metabolic Adaptations, Lactate, and Training Smarter with Dr. Phil Batterson YouTube: https://youtu.be/PPZyO1nxSPA Episode 383: Body Composition, Strength Training, and Sustainable Habits with Martin Silva YouTube: https://youtu.be/p8oM0gW488U Connect with Dr. Jenkins: Website: https://www.drnathanjenkins.com/ Instagram: https://www.instagram.com/drnathanjenkins Get In Touch with Dr Mike: Instagram: Drmiketnelson YouTube: @flexdietcert Email: Miketnelson.com/contact-us Get the Daily Fitness Insider newsletter (free): https://www.miketnelson.com/newsletter

CardioNerds (Dr. Billy-Joe Mullinax, Dr. Dinu Balanescu, and Dr. Jane Ehret) discuss risk stratification in acute pulmonary embolism with Dr. Stavros Konstantinides, Chair of the 2019 ESC Pulmonary Embolism Guidelines. Using a real-world case, this episode explores how modern PE care has moved beyond “massive” and “submassive” labels toward a dynamic, physiology-based approach. The discussion highlights the limitations of static risk scores, the importance of right ventricular dysfunction and biomarkers, and why normotension does not imply stability. Special emphasis is placed on intermediate-high risk PE, early identification of impending hemodynamic collapse, and the role of lactate, serial reassessment, and PERT teams in guiding escalation of care. Audio editing by CardioNerds intern, Joshua Khorsandi.The 2026 American multi-society PE guidelines were published after this episode was recorded. Dr. Dinu Balanescu and Dr. Billy-Joe Mullinax are Co-chairs for the CardioNerds PE Series, developed in collaboration with the PERT Consortium.   Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. CardioNerds Pulmonary Embolism PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls Stable blood pressure does not mean low risk in PEHypotension is a late finding. Patients may have severe RV failure, hypoxia, and tissue hypoperfusion while remaining normotensive — a key concept behind “normotensive shock.” Risk stratification in PE must be dynamic, not staticLegacy scores like PESI and Bova provide a snapshot and predict 30-day mortality, but they do not capture short-term trajectory or impending hemodynamic collapse. Intermediate-high risk PE is a dangerous and heterogeneous groupPatients with RV dysfunction, positive biomarkers, tachycardia, hypoxemia, and elevated lactate may have in-hospital mortality approaching 15%, rivaling STEMI. Lactate is a critical but underutilized marker in PEElevated lactate reflects tissue hypoxia and early circulatory failure and may identify patients at risk for collapse before blood pressure declines. PERT enables physiology-driven, patient-centered PE carePERT teams operationalize continuous reassessment, integrate imaging, labs, and clinical trajectory, and allow timely escalation — shifting PE management from rigid categories to real-time decision-making. Notes Drafted by Dr. Jane Ehret. 1. What is the contemporary framework for risk stratification in acute pulmonary embolism? Modern PE risk stratification prioritizes hemodynamics and right ventricular (RV) function rather than clot burden. The 2019 ESC Guidelines classify PE into high risk, intermediate risk (low vs high), and low risk, based on: Hemodynamic status, RV dysfunction on imaging, and Cardiac biomarkers. This framework emphasizes early mortality risk but requires clinical context to guide escalation decisions. 2. Why is normotension insufficient to define “stability” in PE? Blood pressure is a late marker of circulatory failure in PE. Patients can maintain normal BP through Tachycardia, Increased sympathetic tone, and RV compensation. Many patients with preserved BP may already have shock physiology, including hypoxemia, elevated lactate, and RV failure — sometimes referred to as “normotensive shock.” 3. How should intermediate-risk PE be conceptualized clinically? Intermediate-risk PE is heterogeneous, ranging from patients who do well on anticoagulation to those who deteriorate rapidly. Intermediate-high risk PE is defined by RV dysfunction on imaging and positive cardiac biomarkers. Clinical features such as tachycardia, increasing oxygen requirement, and elevated lactate identify patients at highest risk within this group. 4. What are the strengths and limitations of commonly used PE risk scores? Legacy scores are useful for initial risk categorization but are static and limited in predicting short-term deterioration. Most scores were developed to predict mortality or complications at fixed time points rather than dynamic clinical trajectory. 5. What are the commonly used risk scores and clinical tools in PE, and what is each designed to predict? ESC Risk Stratification Algorithm: Identifies high-risk PE by hemodynamics. Uses PESI or sPESI in normotensive patients to distinguish low-risk from non–low-risk PE. Uses RV dysfunction and biomarkers to differentiate intermediate-low from intermediate-high risk. Forms the basis of many institutional PE pathways. PESI and sPESI: Validated to predict 30-day mortality. Widely used to identify low-risk patients appropriate for outpatient management. Heavily influenced by age and comorbidities. Bova Score: Predicts 30-day PE-related complications in normotensive patients. Composite PE Shock Score (CPES): Predicts normotensive shock in hemodynamically stable PE patients. Pulmonary Embolism Progression (PEP) Score: Predicts progression from intermediate-risk to high-risk PE within 72 hours of diagnosis. PE Short-term Clinical Outcomes Risk Estimation (PE-SCORE): Predicts clinical deterioration or death within 5 days of PE diagnosis. Hestia Criteria: Identifies low-risk PE patients safe for outpatient treatment. Wells' Criteria and Revised Geneva Score: Determine pretest probability for diagnostic triage. PERC Score: Rules out PE in very low-risk patients. 6. What is the role of biomarkers in PE risk stratification? Troponin and natriuretic peptides reflect RV myocardial injury and strain. Current guidelines treat biomarkers as binary (positive vs negative), despite risk being continuous. Biomarkers are most helpful for: Initial risk classification. They are less useful for: Short-interval monitoring and Detecting rapid clinical deterioration. 7. Why is lactate an important physiologic marker in PE? Lactate reflects global tissue hypoxia and impaired perfusion. Elevated lactate may identify patients with: Early circulatory failure and Increased risk of imminent hemodynamic collapse. Lactate is not currently included in ESC risk algorithms but may add important prognostic information in intermediate-risk patients. 8. How does trajectory influence decision-making in PE management? Risk stratification should be viewed as a dynamic process, not a one-time label. Worsening clinical trajectory may include: Rising heart rate, Increasing oxygen needs, Rising lactate, and Progressive RV dysfunction. Serial reassessment is essential for timely escalation of care. 9. What role do Pulmonary Embolism Response Teams (PERT) play in risk stratification? PERT facilitates: Multidisciplinary decision-making and Integration of imaging, biomarkers, and clinical physiology. PERT is most valuable for: Intermediate-risk and high-risk PE and Patients with complex comorbidities or uncertain trajectory. PERT enables a shift from category-based to physiology-driven PE care. References 1. Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J. 2019;54(3):1901647. Published 2019 Oct 9. doi:10.1183/13993003.01647-2019 2. Leidi A, Bex S, Righini M, Berner A, Grosgurin O, Marti C. Risk Stratification in Patients with Acute Pulmonary Embolism: Current Evidence and Perspectives. J Clin Med. 2022;11(9):2533. Published 2022 Apr 30. doi:10.3390/jcm11092533 3. Choi WH, Kwon SU, Jwa YJ, et al. The pulmonary embolism severity index in predicting the prognosis of patients with pulmonary embolism. Korean J Intern Med. 2009;24(2):123-127. doi:10.3904/kjim.2009.24.2.123 4. Jiménez D, Aujesky D, Moores L, et al. Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism. Arch Intern Med. 2010;170(15):1383-1389. doi:10.1001/archinternmed.2010.199 5. Chen X, Shao X, Zhang Y, et al. Assessment of the Bova score for risk stratification of acute normotensive pulmonary embolism: A systematic review and meta-analysis. Thromb Res. 2020;193:99-106. doi:10.1016/j.thromres.2020.05.047 6. Zhang RS, Yuriditsky E, Zhang P, et al. Composite Pulmonary Embolism Shock Score and Risk of Adverse Outcomes in Patients With Pulmonary Embolism. Circ Cardiovasc Interv. 2024;17(8):e014088. doi:10.1161/CIRCINTERVENTIONS.124.014088 7. Zhang RS, Alam U, Sharp ASP, et al. Validating the Composite Pulmonary Embolism Shock Score for Predicting Normotensive Shock in Intermediate-Risk Pulmonary Embolism. Circ Cardiovasc Interv. 2024;17(2):e013399. doi:10.1161/CIRCINTERVENTIONS.123.013399 8. Ehret J, Wakefield D, Badlam J, Antkowiak M, Erdreich B. Development of the Pulmonary Embolism Progression (PEP) score for predicting short-term clinical deterioration in intermediate-risk pulmonary embolism: a single-center retrospective study. J Thromb Thrombolysis. 2025;58(2):243-253. doi:10.1007/s11239-024-03051-5 9. Weekes AJ, Raper JD, Lupez K, et al. Development and validation of a prognostic tool: Pulmonary embolism short-term clinical outcomes risk estimation (PE-SCORE). PLoS One. 2021;16(11):e0260036. Published 2021 Nov 18. doi:10.1371/journal.pone.0260036 10. Zondag W, Hiddinga BI, Crobach MJ, et al. Hestia criteria can discriminate high- from low-risk patients with pulmonary embolism. Eur Respir J. 2013;41(3):588-592. doi:10.1183/09031936.00030412 11. Wells PS, Anderson DR, Rodger M, et al. Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer. Ann Intern Med. 2001;135(2):98-107. doi:10.7326/0003-4819-135-2-200107170-00010 12. Wolf SJ, McCubbin TR, Feldhaus KM, Faragher JP, Adcock DM. Prospective validation of Wells Criteria in the evaluation of patients with suspected pulmonary embolism. Ann Emerg Med. 2004;44(5):503-510. doi:10.1016/j.annemergmed.2004.04.002 13. Le Gal G, Righini M, Roy PM, et al. Prediction of pulmonary embolism in the emergency department: the revised Geneva score. Ann Intern Med. 2006;144(3):165-171. doi:10.7326/0003-4819-144-3-200602070-00004 14. Kline JA, Mitchell AM, Kabrhel C, Richman PB, Courtney DM. Clinical criteria to prevent unnecessary diagnostic testing in emergency department patients with suspected pulmonary embolism. J Thromb Haemost. 2004;2(8):1247-1255. doi:10.1111/j.1538-7836.2004.00790.x 15. Kline JA, Courtney DM, Kabrhel C, et al. Prospective multicenter evaluation of the pulmonary embolism rule-out criteria. J Thromb Haemost. 2008;6(5):772-780. doi:10.1111/j.1538-7836.2008.02944.x

We basked in some amazing news before this great episode! The main topic was a breakdown of one of the most important elements of performance and health: blood volume. Studies show that blood volume can seem to act as a synonym for fitness, with one finding that 6 weeks of training gains can be reversed with a phlebotomy that returns blood volume to baseline levels. Positive adaptations can happen in a few days, and it clearly matters for performance. If any other intervention worked like that, you'd assume everyone would be talking about it all the time. But blood volume is not discussed often! We pull back the curtain on the science.We also talked about a new review article on exogenous lactate supplementation. It might be a brave new world in the next 5 years, but right now there are more questions than answers. We speculate!And this one was full of cool topics! Other topics: the shockingly good news Megan has received in recent heart tests, our disdain for the Enhanced Games, recent age group doping news, the Satisfy Circle Pit, the true GOAT of endurance, running v. biking, uphill treadmill workouts, and lots more.Yes, David actually hit himself for a joke on this episode. Podcasts are definitely the medium for physical and visual comedy.We love you all! HUZZAH!-David and MeganClick "Get 40% Off" button for 40% off at The Feed here: thefeed.com/swapBuy Janji's amazing gear: https://janji.com (code "SWAP")The Wahoo KICKR Run is the best treadmill on the market: https://www.wahoofitness.com/devices/running/treadmills/kickr-run-buy (code “SWAP”)For training plans, weekly bonus podcasts, heart rate zones, articles, and videos: patreon.com/swap

We host Olympian and Norwegian-method innovator Marius Bakken and talk bout the history and principles behind double-threshold training, lactate testing, and “muscle tone” as a key limiter of recovery and performance. Bakken contrasts lessons from coaches like Joe Newton, Peter Coe, and others, emphasizing long-term progression and balancing load with precision rather than uncontrolled intensity.…

Dr. Stephanie Estima gives a masterclass on the often-overlooked role of lactate in how our bodies work during exercise. She's redefining lactate as a key metabolic signal that can help us get stronger, age better and think sharper. In this solo episode, Dr. Stephanie gets into how lactate is made, how it fuels our energy and why it's so important when we push ourselves hard. Dr. Stephanie is a big fan of sprinting because it helps us build metabolic power and stay strong, and she'll also talk about how to use it right and how to recover well. Episode Overview: (0:00) Introduction — Lactate Is Not the Enemy (2:15) Welcome & Episode Roadmap (4:30) The Myth: How We Got Lactate Wrong (7:00) What Lactate Actually Is (The Biochemistry) (9:30) Why Lactate Forms Even With Oxygen (15:00) The Gear Analogy — Don't Be Metabolically Polite (18:00) Metabolic Flexibility & Why HIIT Matters (22:00) How to Dose Your Sprints (Beginner to Advanced) (24:30) The Lactate Shuttle — Redistribution, Not Waste (28:30) Mitochondrial Biogenesis & Longevity Signals (32:00) Lactate and Your Brain — BDNF, Fog & Cognitive Edge (38:30) Dosing, Recovery Rules & Programming (46:00) Closing — You Are Remodelling Yourself Resources mentioned in this episode: https://drstephanieestima.com/podcasts/ep469 We couldn't do it without our sponsors: BON CHARGE - Achieve glowing skin, gain more energy, and uplevel your recovery practice with a suite of red light products. Get 15% off at https://boncharge.com/better with code BETTER. MUSE - Train your nervous system with feedback, the same way you'd train muscles with resistance. If you are ready to unlock your brain's potential, go to https://choosemuse.com/BETTER or use code BETTER at checkout to get started. PIQUE LIFE - If you want to redefine your afternoon and evening rituals and still feel like yourself the next day, you can get 10% off at https://piquelife.com/better TIMELINE   - Timeline's clinically proven formula is now available at a new, lower price . Mitopure now starts at $79, when you go to https://timelinenutrition.com/better with code BETTER. ****************************P.S. When you're ready, here are two ways Dr. Stephanie can help you:Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dans cet épisode, on plonge dans un sujet aussi fascinant que mal compris : les lactates.Souvent perçus comme un outil réservé aux professionnels ou comme un concept complexe de laboratoire, les lactates sont en réalité l'un des indicateurs les plus puissants pour comprendre ce qui se passe réellement dans ton corps à l'entraînement.Pourquoi certains athlètes parlent-ils aujourd'hui de “révolution lactate” ?Pourquoi les Norvégiens ont-ils remis cette mesure au centre de la performance ?Et surtout, comment utiliser concrètement cet outil sans tomber dans l'excès technologique ?Pour répondre à ces questions, je reçois Bastien Kerangoff, fondateur de TRI LAB, expert en physiologie de l'effort et en suivi de performance.Ensemble, on démystifie les lactates et on les replace dans leur vrai rôle : un outil pour devenir un athlète plus précis, plus intelligent et plus durable.AU PROGRAMME- Pourquoi les lactates sont revenus au centre de la performance- Ce que mesure réellement un test lactate- La plus grande incompréhension autour des lactates- Le lien entre lactates, intensité, oxygénation et filières énergétiques- Comment définir précisément ses zones d'intensité- Pourquoi un test terrain peut être plus utile qu'un test en laboratoire- Comment suivre sa progression grâce aux données internes- Les erreurs les plus fréquentes dans l'utilisation des lactates- Jusqu'où un amateur doit aller dans la mesureUn épisode clair, pédagogique et exigeant, destiné aux triathlètes amateurs comme confirmés, aux coachs et à tous ceux qui veulent mettre de la science au service d'une progression durable, sans tomber dans le gadget ou la sur-analyse.Deal NordVPN EXCLUSIF ➼ https://nordvpn.com/loop Profitez de la garantie satisfait ou remboursé de 30 jours de Nord !Cet épisode et cette série sont rendus possibles grâce à mon partenaire nutrition 2026 MNSTRY.Chez MNSTRY, la performance repose sur une approche scientifique, exigeante et durable, avec des produits développés à partir des besoins des athlètes, sans compromis entre performance et santé sur le long terme.Pour découvrir l'ensemble des produits → https://swll.to/MNSTRYPour découvrir Bastien → https://swll.to/bastien-kerangoffPour découvrir Trilab → https://swll.to/trilabBonne écoute.

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Broadcast from KSQD, Santa Cruz on 4-23-2026: Dr. Dawn highlights ARPA-H-funded breakthroughs: Duke researchers created injections enabling cartilage cells to divide and remodel bone, UC Boulder developed intermittent-burst delivery of a repurposed drug that reversed rabbit arthritis in 4-8 weeks, and Columbia printed a living 3D knee using stem cells on biodegradable scaffolding. She notes the agency's budget was cut by $945 million despite requiring human trials within 18 months of funding. A cord blood study across 200 countries links phthalates—found in food packaging, vinyl flooring, shampoos, and toys—to placental disruption and premature birth. Dr. Dawn warns that removing specific chemicals just leads to untested replacements, and urges avoiding microwaving in plastic. An emailer asks about microbiome and exercise motivation. Dr. Dawn describes research showing Veillonella atypica bacteria eat lactate produced during exercise and trigger dopamine production via the vagus nerve, creating a reward loop. Bred "super-runner" mice ran three times longer than average, but antibiotics reduced their running by 21%, implicating microbiome involvement. Dr. Dawn expands on cortisol dynamics: levels should rise gradually from 3 a.m., spike threefold at waking to synchronize hormones, then decline throughout the day. Chronic stress keeps cortisol elevated, while burnout from sustained overproduction eventually exhausts the adrenals and disrupts circadian rhythm, requiring 6-12 months to restore. An emailer asks about food-based detoxification for skin and inflammation. Dr. Dawn explains that plant bioflavonoids—originally insecticides—trigger enzyme production that also breaks down synthetic pollutants, with sulfur-containing vegetables (crucifers, onions, garlic) particularly important. Colorful fruits and vegetables scavenge free radicals that damage DNA and collagen. Dr. Dawn explores red and near-infrared light therapy (600-1100nm), which boosts ATP production by energizing cytochrome c oxidase in mitochondria. The FDA approved a device for dry macular degeneration, and red light is recommended for chemotherapy-induced oral mucositis. She notes modern buildings filter these wavelengths, potentially starving us of light our bodies evolved to need. Dr. Dawn shares research on unsupervised childhood play, citing psychologist Peter Gray's finding that independent play develops internal locus of control—the belief you can influence outcomes. such as youth anxiety and depression, as children no longer learn to self-soothe through tolerating boredom.

This week we welcome Max Swindells. To discuss evidence based training. Max provides his view of what evidence based training means to him and what evidence we can look to in HYROX. Max also provides details of the precise detail he looks to when trying to evaluate athletes prior to their first 12 weeks of training. We also deep dive into the world of Lactate threshold training and VO2 Max to consider how this may guide your training. Finally we consider some of the common tropes in HYROX training and look at what could be reduced or removed to improve training efficiency. Follow Max on Instagram - @maxswindells_fitness   Todays Podcast is sponsored byRowalong - Free indoor rowing workouts for you to RowAlong to - with a friendly voice in your ear. If you have any questions about the show or are interested in advertising with us then please contact admin@ukocr.com Find out more about us by clicking Here Support us on Patreon Here for as little as £2 per month and get all your podcasts Early or Buy us a beer if you like what we do

In case you missed it - one of our favourite episodes from the archives. *Interview starts at 21:45*It was a privilege to chat to Nick Jankovskis, Sport and Exercise Scientist with a Master of High Performance Sport. Nick has an extensive background working with elite athletes across a variety of sports, and currently specialises in performance testing for endurance athletes. Nick shares his expertise on blood lactate and VO2 max analysis for optimal athlete training prescription and output. We chat all about how blood analysis can give us an insight into areas of weakness and strength, allowing a more specific approach to training and recovery. Nick simplifies some complex topics such as lactate threshold, ventilatory threshold and fraction of expired oxygen (FE02). There's so much in the conversation and we know you're going to take so much value.You can find Nick on Instagram @nj_sportscience Need some nutrition or hydration for your endurance training? Use the code TAILWINDSTRONG at www.tailwindnutrition.com.au  You can also use our code STRONGERSTRIDE for 15% off Vivobarefoot shoes at www.solemechanics.com.au  Thanks for all of your support!Dont forget to rate the podcast, leave a review and follow us on instagram @strongerstride to stay up to date. TSSP x

In this episode of the Flex Diet Podcast, I sit down with Dr. Scott Sherr to take a deep dive into methylene blue, mitochondrial function, and where the truth lies between online hype and fear. We talk through how methylene blue acts as a redox cycler in the mitochondria, how dosing differs for mitochondrial support versus antimicrobial use, and why high doses or poorly labeled liquid droppers can cause problems.  Dr. Sherr also shares how he's used methylene blue with athletes for recovery and endurance, including timing, half-life, and practical ranges he sees most often. We cover how mitochondrial health connects to energy, mood, focus, stress physiology, and recovery, plus resources from Transcriptions and the Health Optimization Medicine and Practice (HOMe/HOPe) framework. Sponsors: TROScriptions TX: https://troscriptions.com/?rfsn=9054607.066ddde&utm_source=refersion&utm_medium=affiliate&utm_campaign=9054607.066ddde CODE: DRMIKE Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8 Coming up: ISSN 2026: https://www.sportsnutritionsociety.org/ Available now: Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here. Episode Chapters: 03:11 Why Methylene Blue Now 04:29 Scott Cher Origin Story 05:05 Health Optimization Framework 07:08 Transcriptions and Safe Sourcing 08:46 Natural vs Synthetic Debate 11:49 How Methylene Blue Works 17:42 Who Benefits Most 22:13 Athletic Performance and Recovery 29:41 Dosing Timing and MAOI Effects 32:13 Mitochondria and Fertility 32:28 Energy Anxiety and Brain Fog 33:13 Depression Beyond Serotonin 35:30 Stress Pathways and Cell Danger 37:00 ADHD or Sympathetic Overdrive 38:50 Recovery Metrics and Downregulation 42:21 GABA Support and BBB Clues 47:50 Building Mitochondrial Capacity First 51:35 Methylene Blue Dosing Guide 57:54 Where to Learn More 01:00:24 Podcast Wrap and Disclaimer  Flex Diet Podcasts you may enjoy: Episode 344: Metabolic Adaptations, Lactate, and Training Smarter with Dr. Phil Batterson YouTube: https://www.youtube.com/watch?v=PPZyO1nxSPA Episode 320: Unlocking Mitochondrial Secrets with Dr. Hemal Patel YouTube: https://www.youtube.com/watch?v=lQGXtZjJtQw Connect with Dr Sherr: Instagram: https://www.instagram.com/drscottsherr/ Website: https://drscottsherr.com/ YouTube: https://www.youtube.com/@drscottsherr Get In Touch with Dr Mike: Instagram: Drmiketnelson YouTube: @flexdietcert Email: Miketnelson.com/contact-us

Nutrition debates today often feel more ideological than scientific. One of the biggest examples is the ongoing controversy around seed oils, where strong opinions exist on both sides but clear understanding is often missing.  In this episode, Ted speaks with nutrition scientist Christopher Masterjohn to explore the history and research behind seed oils, cholesterol, fatty liver disease, and oxidative stress. They also discuss why nutrition debates become polarized, how choline intake influences liver health, and why metabolic markers like glucose and lactate can offer useful insights into personal metabolism.   If you want a deeper, more nuanced understanding of one of the most debated topics in nutrition—and practical ways to think about your own diet—this conversation will challenge assumptions and expand your perspective. Listen now.  Today's Guest  Christopher Masterjohn  Christopher Masterjohn is a nutrition scientist with a PhD in Nutritional Sciences. His work focuses on metabolism, micronutrients, and the biochemical mechanisms that influence long-term health. Through his research, writing, and educational platforms, he helps people understand how diet, metabolism, and lifestyle interact to shape metabolic health.    Connect to Christopher Masterjohn  Website: https://www.chrismasterjohn-phd.com   Instagram: @chrismasterjohn   X: @ChrisMasterjohn   Substack: Harnessing the Power of Nutrients   YouTube: @chrismasterjohn  Podcast: Mastering Nutrition Podcast    You'll learn:  Why seed oils became widely promoted—and why the science remains controversial  How polyunsaturated fats influence oxidative stress and long-term disease risk  The overlooked role of choline in preventing fatty liver and supporting metabolic health  How tracking glucose and lactate can provide deeper insight into metabolic function    Chapters:  00:00 Introduction  02:43 Seed Oils Defined  04:20 PUFAs Oxidation Risks  05:53 Heart Disease History  07:51 Trials Cancer Concerns  10:49 Null Hypothesis Debate  18:34 Choline Fatty Liver  33:50 Added Oils and Real Life  39:40 Muscle Over Fat Loss  44:24 Accidental Deficits Example  46:14 Coaching Psychology Nuance  50:59 Lactate and Mitochondria  56:11 Wrap Up and Where to Find 

Neuroscientist Dr. Tommy Wood breaks down what it actually takes to keep your brain sharp as you age. Drawing from his new book The Stimulated Mind, Tommy makes the case that movement is non-negotiable for brain health — and that even small amounts make a meaningful difference. From walking and resistance training to dancing and pickleball, different types of exercise protect different parts of the brain in ways that compound over time. The bottom line? You don't need a perfect plan. You just need to start. Episode Overview: (0:00) Intro/Teaser (7:00) The Exercise Framework: From Snacks to Sprints (11:00) The Norwegian 4x4 Study (14:00) Lactate, BDNF & Why HIIT Is Good for Your Brain (15:00) Resistance Training, White Matter & Decision-Making Speed (17:00) Why Pickleball Beats the Recumbent Bike (24:00) Stress, Cortisol & Inflammation (31:00) Muscle as a Proxy for Brain Health (40:00) Nutrition for Brain Health (53:00) The Female Brain (1:09:00) Brain Training: Languages, Video Games & the Power of Failing (1:23:00) The After-Party with Dr. Stephanie Resources mentioned in this episode: https://drstephanieestima.com/podcasts/ep460 We couldn't do it without our sponsors: PIQUE - Designed to deeply hydrate, enhance skin elasticity & firmness and support sustained energy—exactly what we need during this stage of life. Start your daily ritual today with 20% off for life—plus a free gift to elevate your routine. Head to https://piquelife.com/drestima. COZY EARTH  - Cozy Earth helps you feel better by keeping your temperature perfect overnight to facilitate deep restorative sleep. Head to https://cozyearth.com and use my code BETTER for up to 20% off. KENETIK - You think carefully about how you fuel your body but are you fueling your brain? Learn more about Kenetik and try it for yourself by going to https://drinkkenetik.com/BETTER and use code BETTER for 15% off your purchase. HIGHER DOSE - If you're noticing thinning, shedding, or simply want to support scalp and hair health proactively, this is a powerful addition to your routine. Get 15% off the Red Light Hat at https://higherdose.com with code BETTER at checkout. MINI PAUSE - Join my weekly roundup of the BEST actionable steps for women 40+ who want to gain control of their hormones during perimenopause and menopause. Head over to https://drstephanieestima.com/newsletter/ to sign up now! ****************************P.S. When you're ready, here are two ways Dr. Stephanie can help you:Subscribe: The Mini Pause — My weekly newsletter packed with the most actionable, evidence-based tools for women 40+ to thrive in midlife.Build Muscle: LIFT — My progressive strength training program designed for women in midlife. Form-focused, joint-friendly, and built for real results. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Register for a live Q&A with Dr. Tommy Wood on Wednesday, March 25th.Decreased glucose uptake in the brain is often considered a hallmark of Alzheimer's disease. But Dr. Tommy Wood asks whether part of that metabolic signature may reflect how little cognitive demand we place on the brain.He sits down with Dr. Dominic D'Agostino for a nuanced conversation on metabolic health and cognitive function.. Dr. Wood is a neuroscientist, neonatal brain injury researcher, and author of The Stimulated Mind.This episode follows the metabolic thread through every stage of brain health. Pre-diabetes and type 2 diabetes as predictors of cognitive decline. Neurovascular coupling as the reason heart disease risk factors double as brain disease risk factors. Lactate crossing the blood-brain barrier to drive BDNF production where it actually matters. Creatine as a brain energy distributor that most people still only associate with muscle. Dr. Wood lays out his Three S Model — Stimulus, Supply, Support — and makes the case that cognitive demand drives glucose uptake into the brain the same way muscular contraction drives it into skeletal muscle.Questions Answered in This Episode:Does the brain respond to energy demand the same way skeletal muscle does?What role does creatine play in brain energy distribution, and what do the clinical trials show?Can heavy resistance training produce the same brain-relevant lactate response as HIIT?How should exercise be dosed after a concussion or traumatic brain injury?Is cognitive decline in your 50s, 60s, and 70s actually inevitable, or is that a statistical artifact?Why are pre-diabetes and metabolic syndrome among the strongest predictors of dementia?The mechanistic throughline here is demand-driven metabolism. Dr. Wood makes the case that the same principles governing glucose uptake in skeletal muscle apply to the brain — and the conversation gets into what that means for how we interpret FDG-PET data, design lifestyle interventions, and think about neurodegeneration itself.Find more at DrTommyWood.comSpecial thanks to the sponsors of this episode:✅ Fatty15 – Get 15% off a 90-day Starter Kit with code METABOLICLINK here✅ Troscriptions – Get 10% off your first order with code METABOLICLINK here✅ Toups and Co – Get 15% off your first order with code METABOLIC here✅ ZocDoc - Find and instantly book a top-rated doctor hereIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Episode Summary: In this episode of the Garage Gym Athlete podcast, Jerred Moon and Dave break down how to run longer without fatigue. They unpack five proven strategies that improve endurance and delay exhaustion: High Intensity Interval Training (HIIT) Strength Training Lactate Threshold Training Smart Pacing Hydration and Nutrition Backed by scientific research and real-world experience, this episode emphasizes a balanced training approach that blends intensity, recovery, and intelligent programming. Keywords: running, endurance, HIIT, strength training, lactate threshold, pacing, hydration, carbohydrates, fatigue, performance Key Takeaways: High Intensity Interval Training (HIIT) improves endurance and running economy. Heavy strength training enhances performance and reduces fatigue. Lactate threshold training improves metabolic efficiency. Smart pacing strategies like negative splits conserve energy. Hydration and nutrition delay fatigue during prolonged efforts. Recovery is often the missing piece in endurance training. Combining modalities leads to better overall performance. Understanding your limits is key to improvement. Nutrition is a 24-hour strategy, not just pre-workout. Mental toughness plays a major role in endurance success. Sound Bites: "Run longer without getting tired." "Smart pacing reduces early fatigue." "Nutrition is a 24-hour window." Chapters: 00:00 – Introduction to Running Longer Without Fatigue 08:23 – The Role of Strength Training in Running 14:40 – Understanding Lactate Threshold Training 21:49 – Smart Pacing Strategies for Runners 30:51 – The Importance of Hydration and Nutrition

Dr. Tommy Wood (@DrRagnar) is an associate professor of pediatrics and neuroscience at the University of Washington, where his research focuses on brain health across the lifespan. This includes therapies for brain injury in newborns, prevention and treatment of adult brain trauma, and the factors that contribute to long-term cognitive function and cognitive decline. He is the author of the forthcoming book The Stimulated Mind.This episode is brought to you by:Circle complete community platform for your community, events, and courses — all under your own brand: https://circle.so/tim ($1,000 off when you demo Circle Plus)Monarch track, budget, plan, and do more with your money: Monarch.com/Tim (50% off your first year at monarchmoney.com with code TIM)Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $350 off your very own Pod 5 Ultra.)Cresset family office services for CEOs, founders, and entrepreneurs: CressetCapital.com/Tim*TIMESTAMPS:[00:00:00] Start[00:02:30] The cognition conversation commences.[00:03:11] Why human babies are chubby little brain-fuel tanks.[00:05:16] Brain injury in newborns: Cooling, caffeine, and coming home.[00:09:07] Adult concussion protocol: Fever management, ketones, and why you shouldn't chug Powerade.[00:18:59] Washington's 2nd Strongest Man talks omega-3s, methylation, and why your brain needs the whole orchestra.[00:29:34] Auguste Deter, Alzheimer's mystery patient, and the 45-70% dementia prevention sweet spot.[00:39:22] From CGM monitoring to the “use it or lose it” glucose paradox.[00:55:54] VO2 max training as cardio insurance against dementia.[01:01:32] Jiu-jitsu, sleds, and the Norwegian torture method (4×4 intervals).[01:03:37] Lactate training: Forget the finger prick, embrace the misery.[01:06:40] Announcing The Stimulated Mind: Tommy's brain-saving book.[01:07:35] Foundation supplements: Omega-3s, B vitamins, vitamin D, iron, and magnesium.[01:08:58] Polyphenols, choline, and the case for eating more liver.[01:10:40] Creatine: Tommy's 10-gram cognitive stimulant ritual.[01:11:58] Cheap creatine temptation leads to lavatory lamentation.[01:14:16] Blood flow restriction training: High lactate, low load, maximum travel convenience.[01:21:45] Language learning, music, StarCraft, and why your brain needs to fail.[01:38:04] Sleep anxiety, air pollution, and gum disease: the overlooked dementia risk factors.[01:45:32] Air purifiers, CO2 levels, and sleep optimization hacks.[01:51:52] DORAs for sleep quality: when cognitive stimulation isn't enough.[01:54:55] The thesis behind The Stimulated Mind: Practical, referenced, and sustainable.[01:56:32] Kelly and Juliet Starrett's stamp of approval.[01:57:44] The beautiful compounding effect of fixing just one thing.[01:58:59] Who is Dr. Ragnar, and does he make housecalls to Valhalla?[02:01:06] Tommy's open invitation for complaints and scientific debates.[02:02:21] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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In this episode of the Flex Diet Podcast, I sit down with Dr. Cas Fuchs from Maastricht University to dive into the science behind cold water immersion. We discuss its impact on muscle recovery, protein synthesis, and overall performance. Dr. Fuchs shares his latest research findings, debunking common myths and providing actionable insights for athletes and fitness enthusiasts.Plus, we touch on the effects of different carbohydrates on glycogen resynthesis and liver function. Whether you're a gym-goer or a seasoned athlete, this episode is packed with valuable information to optimize your training and recovery strategies.Sponsors:Fitness Insider Newsletter: https://miketnelson.com/Available now:Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.Episode Chapters:02:15 Starting the Discussion with Dr. Fuchs03:05 Research on Cold Water Immersion04:39 Mechanisms and Effects of Cooling on Muscle Recovery12:08 Long-Term Effects of Cold Water Immersion24:01 Comparing Cooling and Heating Protocols32:35 Placebo Effects and Practical Applications37:57 Debunking Cold Water Immersion for Fat Loss41:01 Exploring the Effects of Cold Water Immersion on Endurance41:50 The Role of Temperature in Muscle Physiology42:40 Practical Applications of Cold Water Immersion44:43 The Myth of Cooling Devices for Performance Enhancement48:37 Pre-Exercise Cold Water Immersion: Benefits and Drawbacks50:58 Glycogen Resynthesis and Carbohydrate Types01:02:50 Recent Research on Breakfast and Liver Glycogen01:06:13 Upcoming Studies and Bodybuilder Research01:09:10 Cold Water Immersion Tips for Gym Goers01:10:40 Conclusion and Contact Information Flex Diet Podcast Episodes You May Enjoy:Episode 202: Cold water immersion and the body's regulation systems: An interview with Dr. Dwayne JacksonYouTube: https://youtu.be/3UfPcOJdmIA?si=Vu4FT12Z5gd4JXkxEpisode 344: Metabolic Adaptations, Lactate, and Training Smarter with Dr. Phil BattersonYouTube: https://youtu.be/PPZyO1nxSPA?si=7BjCBIQBbs7srclyConnect with Cas:Instagram: https://www.instagram.com/casfuchsLinkedIn: https://www.linkedin.com/in/casfuchsGet In Touch with Dr Mike:Instagram: DrmiketnelsonYouTube: @flexdietcertEmail: Miketnelson.com/contact-us

It's a controversial topic, fasting, especially for women. Dr. Mindy Pelz was teaching women to fast primarily because they wanted to lose weight, but what she was witnessing was women saying things like, "I lost weight, but my hair's falling out. I don't have a period anymore. I sat down with Dr. Mindy Pelz, New York Times bestselling author of Age Like a Girl, hormone expert, and the voice redefining fasting for women - because doing it wrong can wreck your health. We explore why fasting affects women differently, how ketones can restore brain function during menopause, and why understanding your hormonal cycle is critical for metabolic health, cognitive performance, and longevity. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro 01:50 What put Dr. Mindy Pelz on the map 03:14 The truth about fasting vs intermittent fasting 05:13 How the brain uses glucose vs ketones 07:25 Why the brain "eats itself" during menopause 10:14 What is mitophagy and cellular autophagy 13:11 Why autophagy is the body's repair system 15:24 The 12-hour vs 17-hour vs 72-hour fast 17:23 Why women's cycles are disrupted by fasting 19:59 The fasting cycle for women 21:05 Lactate as a fuel source for the brain 23:01 Hemoglobin A1C and insulin resistance 27:36 Understanding CGM data correctly 30:13 Where women should start at 48 32:01 HRT: personal decision or necessity? 34:15 The nervous system shift during perimenopause 38:48 The grandmother hypothesis and evolutionary sensitivity 41:09 The "menopause divorce" phenomenon 44:18 Dementia, Alzheimer's, and women46:17 Dopamine, novelty, and neuroplasticity47:23 Cold water immersion and trauma rewiring51:19 Cold water and cortisol for women53:51 Exercise, BDNF, and brain health55:21 Serotonin, light exposure, and sleep58:00 Glycine, bone broth, and longevity01:02:26 Preparing for perimenopause and menopause 01:04:24 Acetylcholine, storytelling, and memory 01:08:38 Why eggs and cholesterol matter for the brain _______ A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: Ketone-IQ: Mental clarity that lasts - without the crash. Visit https://ketone.com/NEURO for 30% OFF your subscription order - PLUS receive a free gift with your second shipment or find Ketone-IQ at Target stores nationwide and get your first shot free! IQBAR: The New Year gives us all a chance to reset. Maximize your brain and body's potential with IQBAR's protein bars, hydration mixes, and mushroom coffees. Text NEURO to 64000 to get 20% off all IQBAR products, plus FREE shipping. Caraway: Visit Carawayhome.com/neuro10 or use code neuro10 at checkout to take an additional 10% off your next purchase. Caraway. Non-Toxic cookware made modern. Cure Hydration: For The Neuro Experience listeners, you can get 20% off your first order at curehydration.com/NEURO with code NEURO. Cure is FSA/HSA approved, so you can use your FSA or HSA funds to stay hydrated the smart way. Jones Road Beauty: Use code NEURO at jonesroadbeauty.com to get a Free Cool Gloss with your first purchase! _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

We got our big juicy pumps for this amazing episode! We started by talking about a couple pieces of personal news, including a shockingly cool number 4 ranking in the Ultra Runner of the Year voting... and some tough health findings from an MRI. The newest shoe review is a medical boot. It's still better than most trail shoes.The big science discussion was on a pair of studies on advanced female runners, with both finding low carbohydrate intake on training days. One of the studies on elite athletes found that 94.3% had low energy availability! We broaden out the discussion into nutritional approaches generally. And David tries to broaden it out into a thinkpiece about the food pyramid. At a certain point, maybe your thinkpiece is so wrong that you eventually loop around and become right? Don't answer that.And this one was full of great topics! Other topics: our approach to training and health with the foot, a study on using heat training to substitute for other types of training, what we'd spend with $200 a month, how we are making money off AI, the Burrito League, some quick thoughts on continuous lactate monitors, Shelby Houlihan and Molly Seidel setting records at trail races, Raya for trail and ultra runners, sleep and FKTs, blood tests and training for downhills in a flat place.We love you all! HUZZAH!-David and MeganClick "Claim Your Sponsorship" for $40 free credit at The Feed here: thefeed.com/swapBuy Janji's amazing gear: https://janji.com (code "SWAP")The Wahoo KICKR Run is the best treadmill on the market: https://www.wahoofitness.com/devices/running/treadmills/kickr-run-buy (code “SWAP”)Athlete Blood Test (code "SWAP"): https://www.athletebloodtest.com/shop/For training plans, weekly bonus podcasts, articles, and videos: patreon.com/swap

In this episode of the Training Science Podcast, Prof Paul Laursen is joined by Stephan Nüsser, performance physiologist and founder of a performance diagnostics lab in Germany, for a deep and practical discussion on lactate testing and endurance performance. Drawing from decades of applied work with cyclists, endurance athletes, and motocross professionals, Stephan explains how lactate can be used to individualize training, define true Zone 2 intensity, and guide long-term athlete development.The conversation explores why lactate is often misunderstood, how production and clearance reflect underlying metabolism, and why longer step protocols can provide clearer insight than fixed threshold formulas. They also discuss carb-optimized nutrition, metabolic flexibility, and why training and fueling should be viewed as a single integrated system rather than separate decisions.References:https://sndc.de/_____________________ Today's speakers:Prof Paul Laursen  https://www.paullaursen.com/   Stephan Nüsser: https://www.instagram.com/sndcde/_____________________ 

This week on the WHOOP Podcast, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes sits down with dual-sport national team athlete and exercise physiologist Dr. Heather Logan-Sprenger. The two take a deep dive into one of the most underrated and often forgotten about habits for human performance: hydration.Dr. Logan-Sprenger shares how growing up in Northern Ontario, watching her dad water flowers and her cat grow winter fur, quietly planted the seeds for a lifelong fascination with physiology, stress, and adaptation. From competing for Team Canada in both ice hockey and road cycling to suffering from heat stroke mid–PhD on hydration, her experience and education show just how fragile — and adaptable — the human body really is.Dr. Holmes and Dr. Logan-Sprenger identify what mild dehydration does to your metabolism, brain, and overall performance, and how hydration needs shift across the menstrual cycle. This episode will teach you the simple hydration strategies, how to calculate your sweat rate at home, and when electrolytes actually matter.(01:07) Dr. Heather Logan-Sprenger Intro: Background in Sport & Physiology(01:49) Training, Nutrition, & Hydration: Unpacking Your Body's Needs(08:06) National-Level Athlete to PhD(10:51) WHOOP Podcast Rapid Fire Questions(13:08) Training At Altitude: Hydration Dos and Don'ts (14:49) The Physiology of Heat Stroke(20:33) Correlation Between Hydration and Carbs While Training(24:51) How The Menstrual Cycle Affects Hydration (31:19) Mechanisms of Dehydration: What Happens To The Body(36:52) Cognitive Disadvantages Of Dehydration(38:56) Dehydration's Effects On The Cardiovascular & Thermoregulatory System(40:35) Dehydration's Effects On The Brain (41:29) Measuring Your Sweat Rate As An Athlete(45:39) Essential Habits To Teach Kids and Athletes About Hydration(49:20) Overhydrating and Mineral Loss with Hydration(53:45) Debunking Hydration Myths(55:54) Heart Rate, Lactate, and Power Output's Relationships to Hydration(59:48) Dr. Logan-Sprenger's Ideal Hydration Study: Mitochondrial Hypoxia and Metabolism(01:05:23) OutroFollow Dr. Heather Logan-SprengerLinkedInInstagramPeakgenicsSupport the showFollow WHOOP: Sign up for WHOOP Advanced Labs Trial WHOOP for Free www.whoop.com Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn

What if thousands of steps of gentle walking aren't giving you the brain protection you think they are? In this solo episode, I break down one of the most important exercise studies published in Nature Communications and what it means for your brain, longevity, and Alzheimer's risk. Tracking over 73,000 people for eight years using wearables, the findings are shocking: one minute of vigorous exercise is worth up to 10 minutes of moderate activity — not the outdated 2-to-1 rule. For diabetes prevention, it's nearly 10-to-1. For cardiovascular mortality, it's 8-to-1. And here's what no one is saying: every outcome measured — heart disease, diabetes, metabolic dysfunction — is an independent risk factor for Alzheimer's and dementia. I explain why vigorous exercise is so powerful for your brain: shear stress that strengthens blood vessels, lactate that triggers BDNF, muscle fiber recruitment that protects against falls and cognitive decline, and glucose regulation that defends against insulin resistance — a driver of neurodegeneration. Think vigorous exercise is out of reach? Good news: the study defines it as brisk stairs, carrying groceries, or playing actively with your kids. No gym required — just effort. Just 3–4 minutes of vigorous bursts per day can reduce all-cause mortality by 40% and cardiovascular events by nearly 50%. For women over 40, this is critical. Two-thirds of Alzheimer's cases are women, and perimenopause is a vulnerability window for the brain. Vigorous exercise can partially compensate for declining estrogen by improving glucose regulation, reducing inflammation, and protecting the brain in ways gentle movement cannot. *** Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/brain-code-yt Subscribe to The Neuro Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey. *** A huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts: Rho NutritionYou can get 20% off with the code NEURO at https://rhonutrition.com Function HealthVisit https://functionhealth.com/louisa or use gift code NEURO100 at sign-up to own your health. AquaTruGo to https://AquaTru.com now for 20% off using promo code NEURO. TimelineHead to https://www.timeline.com/neuro to get 20% off. Cure HydrationGet 20% off your first order at https://curehydration.com/neuro with code NEURO. *** I'm Louisa Nicola — clinical neurophysiologist — Alzheimer's prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain — reducing Alzheimer's risk — and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Topics discussed:00:00:00 Introduction: The Exercise Intensity Revolution 00:01:02 The Study That Changes Everything 00:04:50 The Flawed Foundation: Why Guidelines Were Wrong 00:06:50 The Real Numbers: 4 to 10 Times More Powerful 00:08:53 The Brain Connection No One Is Talking About 00:15:32 Mechanism 1: Shear Stress and Cerebral Blood Flow 00:17:38 Mechanism 2: Lactate and BDNF Production 00:19:25 Mechanism 3: Type 2 Muscle Fibers and Myokines 00:24:30 Mechanism 4: Glucose Regulation and Mitochondrial Health 00:28:18 VILPA: The 3-Minute Daily Game Changer 00:32:16 Women and Menopause: The Critical Window 00:35:19 Practical Protocols: What to Do Starting Today Learn more about your ad choices. Visit megaphone.fm/adchoices

Shannon is the Founder & CEO of MyBya.com and the MyBya App, the author of The Lactate Revolution and a 4-time World Championships Triathlon top-10 finisher. This speed-focused talk is the third in a series that Shannon has prepared for us on using lactate data to improve training and performance.If you've got a topic to share, contact David Mitchell to learn more.

Find out more about Coach Steve HERE https://insidethebigring.org www.madisonmultisport.com   ---- Check out Coach Steve's Youtube https://www.youtube.com/@StevenBrandesTRI ---- If you are looking at a consultation with Coach Steve to talk training, racing, aero set ups, and nutrition book here! www.insidethebigring.org/coaching ---- Check out Coach Steve's IRONMAN and 70.3 Training Plans you can BUY! https://shorturl.at/w4kmv ---- If you are into MORE PODCASTS, CLICK HERE!!! https://insidethebigring.org/podcast   Submit Podcast Questions https://insidethebigring.org/podcast-questions   Look into Coaching Consultations https://insidethebigring.org/coaching

My new book Running Breakthroughs is available now as audiobook, authographed book and eBook at https://florisgierman.com. It's a summary of 10 years podcasting lessons, takeaways from coaching thousands of athletes and my own breakthroughs in running and life.     Today Round 5 with Dr. Maffetone on The Extramilest Show. Overtraining is one of the most common reasons runners plateau, burn out, or get slower despite training harder. Dr. Maffetone breaks down how hidden stress, poor recovery, and misunderstood nutrition can quietly sabotage performance + tools to build health first so speed and consistency can follow.   Watch this full video on YouTube: https://youtu.be/NO6GBkODkR4      CHAPTERS: 0:00 - Low Heart Rate Training + Overtraining + Recovery 1:43 - Running Breakthroughs signed copies 2:42 - My favorite running apparel Path Projects 3:22 - Round 5 with Dr. Phil 4:41 - What creates athlete breakthroughs 10:16 - How stress slows you down 14:28 - The "gray zone" & low heart rate training 20:29 - Lactate shuttles & aerobic speed 27:44 - Why low HR training doesn't work for some 32:47 - Refined carbs & brain health 36:07 - Common carbs & better alternatives 39:16 - Are there better bread options? 42:45 - What athletes should eat 44:45 - Potatoes, rice, and carbs explained 47:22 - Cholesterol & fat myths 52:47 - Testing nutrition instead of guessing 54:37 - Why enjoyment matters 56:40 - Common training misconceptions 58:17 - Overtraining warning signs 1:02:15 - Resting heart rate & hidden stress 1:09:48 - Strength training and why it matters 1:14:05 - Recovering from burnout 1:18:55 - Where to find Dr. Phil's study 1:19:38 - How to be a healthier, stronger, happier athlete   FIND DR. MAFFETONE: ► Website: https://maffetonemusic.com/  ► Frontiers Full Paper by Dr Maffetone: https://tinyurl.com/frontiers-maffetone  ► Press Release Brain Research: https://maffetonemusic.com/press-release-brain-research    LINKS & TOOLS MENTIONED ► My new book Running Breakthroughs: https://florisgierman.com/ ► More options to buy the book worldwide on Amazon: https://geni.us/running-breakthroughs  ► Path Projects: https://pathprojects.com/flo    ► Dr. Phil's Study: https://maffetonemusic.com/  ► Episode with Brent Cunningham: https://youtu.be/L3vsBmqelq4  ► Episode with Dr. Marco Guazzelli: https://youtu.be/C8rxNRDPMCI  ► Episode with Dr. Rangan Chatterjee: https://youtu.be/mF0CCpy3Dzo  ► Episode with Kilian Jornet: https://youtu.be/cU7cNo7ZwUk  ► Episode with Mark Allen: https://youtu.be/YlBUJTIggyA      YOU CAN FIND ME, COACH FLORIS GIERMAN HERE:  ► My book Running Breakthroughs as Audio book, Printed Book & eBook: https://geni.us/runningbreakthroughs  ► Our Personal Best Coaching Program: https://www.pbprogram.com/  ► YouTube: https://www.youtube.com/florisgierman ► Strava: https://www.strava.com/athletes/1329785  ► Instagram: https://www.instagram.com/florisgierman  ► Extramilest: https://extramilest.com/  ► Path Projects: https://pathprojects.com/flo ► Podcast: https://extramilest.com/podcast/    Affiliate Disclosure: I may earn commissions if you purchase items via my affiliate links. "As an affiliate I earn from qualifying purchases." Affiliate links do not increase cost to you. Also, you do not need to use these links. You can also search for these same items in Amazon or on any search engine/shopping site of your choice and buy/research them that way.     ABOUT THE EXTRAMILEST SHOW: A podcast and YouTube channel where host Floris Gierman interviews world class athletes, coaches and health experts on the topic of how to become a stronger, healthier and happier athlete.     More info about our Personal Best Running Coaching Program can be found at https://www.pbprogram.com.      SUBSCRIBE and hit the bell to see new videos: https://bit.ly/Flo-YT

Olav joins David again to answer a series of listener questions.  (00:00) Introduction(01:00) What Changes for Olav at UNO-X Now That the Men are a World Tour Team? (07:00) Lactate and Expiring Lactate Strips(09:13) The Impact of Caffeine on Lactate Readings (16:24) The Impact of Altitude and Heat on Lactate Readings (21:24) Periodising Supplements like Bicarb and Plasmaide (24:39) SmO2 and Training Prescription (34:40) Getting Reliable Data when Using SmO2 During Running(38:17) The Biggest Myth Olav Wants to Dispel (41:32) How Does Olav Motivate His Athletes (58:44) What is the Next Big Thing in Triathlon? (1:08:00) What Role Would Olav Add to a High Performance Organisation? Thanks to the sponsors of this podcast series:VO2Master To book your 1 on 1 call head to https://vo2master.com/norwegian-method/Website: https://vo2master.com/ Instagram: @vo2masterYouTube: https://www.youtube.com/c/VO2Master MaurtenTo benefit from the one-time code and get 20% off your next purchase on Maurten.com, simply enter the code “TNMS1” at checkout. The code is applicable once per customer, on all products except the Maurten Bicarb System, valid until 31/12/2025.Maurten WebsiteInstagram: @maurten_officialYouTube: https://www.youtube.com/c/MaurtenOfficialHosted, edited and produced by Dr David LipmanEditing, video and introduction by Roj Ferman

Send us a textIntegration of brain metabolism with neural signaling, highlighting how core metabolites regulate energy use and protect neurons.Topics Discussed:Brain energy efficiency: Brains are much more energy-efficient than computers for similar processing, relying on adaptive metabolic strategies evolved under energy scarcity.Metabolism vs. information processing: Core metabolites like glutamate bridge basic cellular energy production and neural signaling.Lactate as a signal: Produced during exercise, lactate diffuses from muscles to brain, modulating neuronal excitability and providing neuroprotection.BHB in ketosis: During fasting or ketogenic diets, beta-hydroxybutyrate displaces glucose as fuel, enhances antioxidant defenses, and activates protective potassium channels in neurons.Adenosine and sleep: Accumulates from ATP breakdown during wakefulness, triggering sleep and locally inhibiting overactive neural networks for energy conservation.Glial cells' role: Astrocytes and oligodendrocytes handle sophisticated metabolism, release signaling molecules like lactate, and modulate synapses, and influence diseases like Alzheimer's.Practical Takeaways:Regular exercise elevates lactate, which signals the brain to adapt metabolism and may enhance neuroprotection against stress.Intermittent fasting or ketogenic diets can induce ketosis with BHB, potentially boosting brain antioxidant defenses and preconditioning against metabolic stress.Prioritizing sleep helps clear adenosine buildup, restoring energy balance and supporting long-term neural health.About the guest: Dr. Luis Felipe Barros, MD, PhD is a Chilean neurobiologist and professor at the Universidad de Valparaíso, where he leads a lab studying brain metabolism from glucose transport to mitochondrial function.Related Episode:M&M 255 | Unlocking Energy: How Nutrition & Drugs Impact Your Mitochondria | Chris Masterjohn*Not medical advice.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Special sale Nov 10 - Dec 1: Lumen is half off ($599 → $299), and MINDMATTER gets another 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, get $100 off for AquaTru Carafe, Classic and Under the Sink Units, and $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

In this episode of the Flex Diet Podcast, I sit down with my good friend Dr. Tommy Wood to dig into his upcoming book, The Stimulated Mind — a ridiculously practical guide to building a better brain.We get into all kinds of fun rabbit holes: how technology is changing fitness, why lactate (yes, the same stuff you curse during hard intervals) is actually rocket fuel for your brain, and why a solid dose of cardio is one of the most underrated cognitive enhancers out there.We also tackle resistance training, neuroplasticity as you age, and which sports and drills actually move the needle for cognition. And because it's Tommy, we even wander into the spicy territory of psychedelics and whether they may have a place in brain health.If you want real, actionable strategies to boost memory, focus, and long-term cognitive performance—without drowning in jargon—this episode is for you.Tune in and geek out with us.Sponsors:LMNT electrolyte drink mix: https://drinklmnt.com/Flex 4: Dr Tommy Wood's top 4 ways to improve your brain Preorder The Stimulated Mind: https://www.amazon.com/Stimulated-Mind-Future-Proof-Brain-Dementia/dp/0593797817/ref=sr_1_1Triphasic 2 book now available!Go to https://triphasic2.com/Episode Chapters:02:01 Dr. Tommy Wood's Background and Expertise03:15 The Stimulated Mind: Translating Neuroscience into Practical Tips04:01 Sponsors and Special Offers05:09 Interview with Dr. Tommy Wood Begins06:58 The Benefits of High-Intensity Exercise10:37 Lactate and BDNF: Brain Fertilizer17:16 The Potential of Lactate Supplements20:49 The Challenges of Translating Preclinical Science to Humans26:54 The Importance of the Hippocampus and Executive Function29:53 The Benefits of Resistance Training for Cognitive Health32:09 The Cognitive Benefits of Coordinative Training34:30 The Importance of Recreation and Social Interaction37:34 The Humbling Nature of Brazilian Jiu-Jitsu38:12 The Stimulated Mind: Brain Function and Exercise40:06 Neuroplasticity and Aging40:50 Embracing Discomfort for Brain Growth42:47 The Role of Dopamine in Learning45:14 Flow vs. Clutch States in Performance48:41 The Goat Drill: A Complex Motor Skill Exercise53:13 Expanding Cognitive Headroom58:00 Psychedelics and Brain Health01:03:26 Wrapping Up: Book Promotion and Final ThoughtsFlex Diet Podcast Episodes You May Enjoy: Episode 307: The Lost Episode on Body Composition Research with Dr. Tommy Wood and Dr. Ben HouseYouTube: https://youtu.be/ytbNiJ25kiQ Episode 178: Rebroadcast – Insulin and Glucose Myths & more with Dr Tommy WoodYouTube: https://youtu.be/N7LchLtBJr4Connect with Dr. Tommy Wood: Substack: https://substack.com/@betterbrainfitnessInstagram: https://www.instagram.com/drtommywoodWebsite: https://www.drtommywood.com/Get In Touch with Dr Mike:Instagram: https://www.instagram.com/drmiketnelson/YouTube: https://www.youtube.com/channel/UCn1aTbQqHglfNrENPm0GTpgEmail: https://miketnelson.com/contact-us/

Thank you to our sponsors:✨ Previnex: Previnex creates clinically effective, third-party tested supplements made with high-quality ingredients, including Muscle Health Plus (creatine). Use the code treadlightly for 15% off your first order at previnex.com✨ Amazfit: User-friendly simple running watches with advanced features, at an affordable price point. Use link http://bit.ly/4nai73H for 10% off your purchase.✨ FlipBelt: Sleek storage options, including no-bounce running belts and shorts. Use code TLF20 at flipbelt.com for 20% off your purchase.In this episode, you will learn:✅ Is there such thing as too much running?✅ On the colon cancer and running study✅ Is too much running bad for your heart?✅ Does running help with mood disorders and mental health?✅ Age-related declines✅ Creating a training plan for running for healthField Tests for our Listener Question:Cooper test: After a 10-20 min warm-up, run as far as you can in 12 minutes. Record distance and enter into this calculator.1.5-mile run test: After a 10-20 min warm-up, run as fast as you can for 1.5 miles. Record distance and enter into this calculator.Lactate threshold test. After a 10-20 min warm-up, run 30 minutes as fast as you can (self-paced, even effort). Your average pace over the final 20 minutes is your velocity at second LT (60-min race pace) and your average HR over the final 20 min is your LTHR.If you enjoyed this episode, you may also like:

Ladies and gentlemen — howdy & aloha! We are HERE, you are THERE, and you're now rockin' with the best. We're lacing up with Coach Bradley Sowder, Director of Cross Country & Track & Field at University of the Cumberlands—back for Round 3 on ABR. We dig into the Patriots' rise (WXC currently top-3, MXC top-4), winning NAIA indoor/outdoor national titles (first men's double in program history), the women's 2025 NAIA Indoor Championship, double-threshold evolution, culture in the transfer/NIL era, and why elite athletes still choose Williamsburg…including the story behind Luca Madeo's return and a run at the German half-marathon record.Listen / Watch Everywhere• YouTube: @AireyBros• Spotify • Apple PodcastsFollow & Support ABR• Instagram: @aireybrosradio• ☕ Buy Me a Coffee Apple Podcasts • Fueled by: Black Sheep Endurance Coaching Coach / Program Links• Coach: Bradley Sowder (University of the Cumberlands) • Program site: Cumberlands XC (Men / Women) & Track & Field (Men / Women) • Team IG: @ucpatriotsxctf (day-to-day updates, recruiting DMsSHOW NOTES / TIMESTAMPS 00:00 – Howdy & aloha intro; ABR mission to spotlight NAIA/NJCAA/D2/D3 distance programs01:01 – Guest intro: Coach Bradley Sowder; current polls (W #3, M #4); UC Patriot pedigree02:57 – Where to send recruits/parents/fans; @ucpatriotsxctf and SIDs doing work  03:59 – Flowers: how Coach Sowder helped launch ABR's TF/XC run; opening doors across divisions06:00 – Kentucky/UK years; teammates John Richardson & Chris Landers; faith & growth arc09:23 – Fall update: depth, vibe, individual meetings, mid-season reset; coach becoming present15:01 – Therapy, pressure, “fear of losing,” hospital scare; reframing wins/losses; leadership growth18:42 – Delegation to staff; balance & family time; being Director and Coach25:01 – Women's rise without last year's “superstars”; transfers/frosh stepping up; depth matters27:27 – Culture with the portal/NIL: 1-year “contracts,” honesty with athletes, helping them level up29:58 – Personal: losing an athlete vs supporting them; why relationships outlast rosters33:36 – Keeping culture strong when top sticks leave; gratitude practice at weekly 125-athlete meeting36:55 – From jail to graduate: why UC's program is built on second chances & accountability38:20 – Silver linings: when multiple athletes earn bigger scholarships—you're doing something right41:07 – Luca Madeo story: Raleigh Relays breakout → altitude year → returns to UC; fifth-year plan; fall target for German HM record & indoor focus (context: UC roster page) University of the Cumberlands Athletics 47:00 – Lactate-guided training: double-threshold tuning (AM vs PM lactate), European athletes bringing meters, individualization54:41 – Benchmarks: Patriot session (tempo + Ks + 600s/400s), classic 12-8-4 x2 ladder, Michigan; last-5-weeks template58:38 – Why fitness is built before November; don't “win the workout/lose the week”59:50 – Who to watch? Everyone. Multiple Conference Athletes of the Week = depth & competition1:02:00 – Load plan to Conference & Nationals (Appalachian Challenge; Milligan, Montreat, TWC in field)1:04:34 – Nationals site strategy: Tallahassee course demands > weather; BYU/ND film study1:09:05 – Final Four: gratitude list; shout to Coach James; daily walk; cappuccino count1:14:16 – Lifting vs running cycles; Boost treadmills for durability; 305 bench @ 44; old-man strength1:21:00 – Deftones dad-daughter car rides; 90s/00s alt-metal lifeblood1:25:49 – Shoutouts to AD Chris Kraftick & staff; UC season outlook; ABR NJ week preview

Shannon is the Founder & CEO of MyBya.com and the MyBya App, the author of The Lactate Revolution, and a 4-time World Championships Triathlon top-10 finisher. This is the first in a series that Shannon has prepared for us on using lactate data to improve training. Click HERE for a visual chart that accompanies this episode.If you'd like to contribute an episode, contact David Mitchell at clientrelations@coacho.com to learn more.

In this episode, Angela sits down with Ulrich Dempfle, co-founder and CEO of CAROL Bike, to uncover the science and innovation behind one of the most time-efficient ways to boost VO₂ max, metabolic health, and brain function. Ulrich explains why VO₂ max is the most important marker for longevity, how it declines without training, and how short, AI-guided REHIT sprints boost mitochondria, BDNF (brain-derived neurotrophic factor), and cardiovascular fitness in just minutes. He also breaks down how Reduced-Exertion High-Intensity Interval Training (REHIT) works, why traditional zone 2 training doesn't work for everyone, and how gamification and real-time performance data make staying consistent easier than ever. What You'll Learn: Why VO₂ max is the strongest predictor of health and longevity How REHIT delivers major fitness gains in just minutes Why zone 2 training doesn't work for everyone How short, AI-guided sprints boost mitochondria and brain function Metabolic and cognitive benefits of REHIT How CAROL Bike personalises training to maximise VO₂ max TIMESTAMPS 00:00 Intro & The Importance of VO₂ Max 01:00 How VO₂ Max Declines and Why It Matters 04:22 Zone 2 Training Myths & Non-Responders 09:09 Mitochondria 101: Density vs. Efficiency 12:00 The Science Behind REHIT & CAROL Bike 19:09 Gamification, Dopamine & Workout Adherence 22:02 Lactate, BDNF & Brain Health Benefits 26:04 Insulin Sensitivity & Metabolic Effects 30:17 Efficient Weekly Training Structure 34:51 Afterburn Effect & Fat Oxidation Misconceptions 45:00 VO₂ Max Testing & Fitness Score Tracking 52:00 Peer-Reviewed Research & AI Personalisation 57:30 Real-World VO₂ Max Improvements 1:01:00 How to Get Started & Special Listener Offer VALUABLE RESOURCES ⁠Join The High Performance Health Community⁠ ⁠Click here⁠ for discounts on all the products I personally use and recommend A BIG thank you to our sponsors who make the show possible: Exclusive discount for podcast listeners on Carol Bike - the bike that gets you fittest the fastest - click here WWW.CAROLBIKE.COM and use code ANGELA Hormone Harmony - go to LVLUPHEALTH.COM/ANGELA and use the code ANGELA at checkout for an exclusive 15% off ABOUT THE GUEST Ulrich Dempfle is the CEO and co-founder of CAROL Bike, the world's first Reduced Exertion HIIT (REHIT) exercise bike. Originally trained as a mechanical engineer in Germany, Ulrich began his career in the automotive industry before moving to the UK to pioneer AI in healthcare systems. After discovering REHIT through a BBC documentary, he partnered with leading exercise scientists to bring this lab-based protocol to the public. Today, Ulrich leads CAROL's product development, combining science, data, and technology to deliver the most time-efficient cardio workout. CAROL website: https://carolbike.com/ Find CAROL Bike on all platforms @theCAROLbike ABOUT THE HOST Angela Foster is an award-winning Nutritionist, Health & Performance Coach, Speaker, and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in Huff Post, Runners World, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️, a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and family without burning out. DISCLAIMER The High Performance Health Podcast is for general information purposes only and does not constitute professional or coaching advice, nor does it form a client relationship. The use of information on this podcast, or materials linked from this podcast, is at the user's own risk. Always seek advice from your medical doctor or healthcare professional before implementing any changes.

It's finally here, the lactate episode! David and Olav discuss lactate, how it can be used, limitations, mistakes, misnomers and the best way to sample lactate. (00:00) Introduction(00:43) How Many Lactate Samples Has Olav Taken(01:36) What is Lactate?(03:00) Lactate is NOT a Waste Product   (05:20) Understanding Metabolism with Lactate   (10:50) What Factors Impact Lactate Concentrations?   (19:10) When is Low Lactate Bad?(21:20) Other Contextual Factors for Lactate Interpretation(26:52) The Need for Repeated Lactate Sampling(29:44) Other Mistakes People Make with Lactate Sampling  (37:21) Myths and Misconceptions of Lactate  (42:32) Correlating Lactate to Perception(43:13) Generating a Lactate Profile on an Athlete(50:45) Lactate Metabolism and Thresholds(51:20) Using Lactate for Intensity Control(54:16) Relative vs Absolute Intensity(58:07) LT2 and LT1(1:03:44) Olav's Procedure for Sampling Lactate(1:06:21) Finger vs Ear Lobe Sampling Thanks to the sponsors of this podcast series:VO2Master To book your 1 on 1 call head to https://vo2master.com/norwegian-method/Website: https://vo2master.com/ Instagram: @vo2masterYouTube: https://www.youtube.com/c/VO2Master MaurtenTo benefit from the one-time code and get 20% off your next purchase on Maurten.com, simply enter the code “TNMS1” at checkout. The code is applicable once per customer, on all products except the Maurten Bicarb System, valid until 31/12/2025.Maurten WebsiteInstagram: @maurten_officialYouTube: https://www.youtube.com/c/MaurtenOfficialHosted, edited and produced by Dr David LipmanEditing, video and introduction by Roj Ferman

VO2max is trendy right now - but is training for VO2max legit or grift? We dive into the science of VO2max, how to improve it, and if it actually matters for long-distance runners. Thank you to our sponsors:✨ Upstep: Custom orthotics, molded from the comfort of your home. Use code RUNTOTHEFINISH at https://www.upstep.com/?ref=cajmuang for $20 off your purchase. ✨ FlipBelt: Sleek storage options, including no-bounce running belts and shorts. Use code TLF20 at flipbelt.com for 20% off your purchase. In this episode, you will learn:✅ What is your VO2max?✅ What do VO2max numbers actually mean? ✅ How is VO2max calculated?✅ Is your Garmin's VO2max estimate accurate?✅ How much does VO2max matter for performance?✅ How to improve your VO2max✅ Can you improve your performance without changing your VO2max?✅ Is VO2max a health indicator?Field Tests for VO2max:Cooper test: After a 10-20 min warm-up, run as far as you can in 12 minutes. Record distance and enter into this calculator. 1.5-mile run test: After a 10-20 min warm-up, run as fast as you can for 1.5 miles. Record distance and enter into this calculator.Lactate threshold test. After a 10-20 min warm-up, run 30 minutes as fast as you can (self-paced, even effort). Your average pace over the final 20 minutes is your velocity at second LT (60-min race pace) and your average HR over the final 20 min is your LTHR. References:

On this episode of the Flex Diet Podcast, I'm joined once again by Dr. Phil Batterson to nerd out on one of my favorite topics: anaerobic metabolism. We dig into what's really happening during high-intensity training, the role of lactate, and why much of the “anaerobic vs. aerobic” discussion you hear is oversimplified (or just plain wrong).We also get into the nuts and bolts of how your bioenergetic systems adapt, why cardio equipment can actually be a powerful training tool, and where metabolic carts fit into the picture. Along the way, Phil drops practical examples you can use to better understand your own performance. If you want a clear, science-backed breakdown of anaerobic training without the fluff, this episode is for you.Sponsors:LMNT electrolyte drink mix: https://drinklmnt.com/Get your rower and assault bike at Rouge https://miket.me/rogueAvailable now:Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.Episode Chapters:04:58 Personal Updates and Business Insights12:37 Anaerobic vs. Aerobic Metabolism Discussion15:00 Training Techniques and Adaptations21:07 Challenges in Hybrid Training24:43 Exploring the ATP-PC System33:59 Introduction to Bioenergetic Systems34:05 Understanding Energy Systems in Exercise34:35 The Role of ATP and Phosphocreatine35:08 Intensity and Energy System Utilization35:46 Fatigue and Muscle Contraction36:38 Misconceptions in Exercise Physiology37:42 Lactate and Its Role in Exercise40:18 High-Intensity Training Adaptations41:46 VO2 Max and Training Protocols42:40 Balancing Aerobic and Anaerobic Training43:58 Effective Training Strategies55:00 Heart Rate and Performance Metrics01:00:07 Lactate: Myths and Realities01:09:30 Buffering Capacity and Adaptations01:16:03 BFR Bands and Intense Workouts01:16:38 The Importance of Cardiovascular Training for Lifters01:17:21 Debunking Myths About Cardiac Development01:18:04 Anaerobic and Aerobic Training Insights01:18:47 Effective Aerobic Training Strategies01:19:42 Maintaining VO2 Max with Minimal Effort01:20:12 Mitochondrial Function and Effective Workouts01:20:49 Where to Find Dr. Phil Batterson01:24:13 VO2 Max Testing and Interpretation01:28:42 Challenges in Lactate Threshold Testing01:39:00 Dynamic Range and Performance01:44:59 Conclusion and Final ThoughtsFlex Diet Podcasts You May Enjoy: Episode 264: Finding Your Aerobic Sweet Spot for Peak Health with Dr Phil BattersonYouTube: https://youtu.be/5j90cmi_I6k Episode 275: Mastering Combat Sports Conditioning Using Advanced Training Techniques with Strength Coach James TognariniYouTube: https://youtu.be/t9Hc-VrsY4kConnect with Dr Phil Batterson:Instagram: https://www.instagram.com/drphilbatterson/Get In Touch with Dr Mike:Instagram: DrmiketnelsonYouTube: @flexdietcertEmail: Miketnelson.com/contact-us

Many cyclists obsess over VO₂max, but what if that number isn't telling the full story? In this episode, I break down what VO₂max actually measures, its limits as a performance predictor, and which metrics (like FTP, lactate threshold, and durability) can matter more for mountain bikers and gravel cyclists. You'll learn how to structure your training to improve what really counts, and why strength training should absolutely be part of your routine. Whether you're an intermediate rider or an experienced racer, this episode will help you train smarter, not just harder. ✅ What You'll Learn: What VO₂max really is (and what it isn't) Why lactate threshold and FTP are better performance predictors The science behind durability and how to train it How strength training improves cycling economy and fatigue resistance

Rhonda Patrick, Ph.D. (@foundmyfitness) is a biomedical scientist and the founder of FoundMyFitness, a platform dedicated to delivering rigorous, evidence-based insights on improving healthspan and mitigating age-related diseases.Sponsors:Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)Momentous high-quality creatine and other supplements: https://livemomentous.com/tim (code TIM for up to 35% off)David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/tim (Buy 4 cartons, get the 5th free.)Monarch Money track, budget, plan, and do more with your money: MonarchMoney.com/Tim (50% off your first year at monarchmoney.com with code TIM)Timestamps:[00:00:00] Start.[00:04:54] Dealing with aging parents and other topics on the table.[00:10:43] How a common multivitamin helps reverse cognitive and memory aging.[00:12:04] The importance of supplementation — especially as we age.[00:13:10] Effectively supplementing with omega-3 fish oil to counter APOE4 and Alzheimer's risks.[00:16:50] The CoQ10 and omega-3 protocol that has helped Rhonda's father manage Parkinson's symptoms for nearly a decade.[00:19:28] Sulforaphane: a potent NRF2 activator with an unexpected benefit for Rhonda's mother's tremors.[00:25:34] How Rhonda convinced her mom to start CrossFit and the power of community-based, senior-focused fitness.[00:26:52] The earlier the intervention, the better the outcomes.[00:32:25] Intermittent fasting vs. extended fasting and my own results.[00:44:31] Does fasting destroy muscle mass? Debunking the catabolism fear and understanding the crucial role of the re-feeding phase.[00:57:24] "Dirty" fasting: what really happens to autophagy and metabolic benefits when you add a splash of cream or MCT oil to your coffee?[01:00:44] VO2 max: the one metric that may predict lifespan more accurately than anything else, and how we work to improve it.[01:12:07] How a two-year exercise program reversed heart aging by 20 years in previously sedentary, middle-aged adults.[01:16:18] Lactate isn't the enemy: how vigorous exercise creates a superfuel that protects and grows the brain.[01:20:30] The optimal sauna protocol (temperature and frequency) for slashing dementia risk by 66%.[01:29:17] If you're human, you'll find a use for curcumin.[01:30:43] Creatine for cognition: moving beyond the gym with a powerful, science-backed tool for focus and combating sleep deprivation.[01:42:41] Still vitamin D deficient despite taking supplements? Here's the critical cofactor you're probably missing.[01:53:52] Shocking sources of microplastics in our daily lives, including chewing gum and teabags.[02:04:10] The uncomfortable truth about "moderate" alcohol consumption, cancer risk, and why the "sick quitter" hypothesis makes most older studies unreliable.[02:17:03] The ups and downs of ketamine and psilocybin on cognition and longevity.[02:24:19] Parting thoughts and where to find more from Rhonda.*Show notes for this episode: https://tim.blog/2025/07/24/dr-rhonda-patrick/For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this “Ask Me Anything” (AMA) episode, Peter addresses frequently requested topics, including brain health, exercise programming, and body composition. He explores the factors that influence dementia risk—including metabolic health, fitness, sleep, hearing, cholesterol levels, and more. He explains how to implement zone 2 training and VO₂ max intervals for cardiovascular fitness and also covers how to combine cardio modalities, how to stay in zone 2, and special considerations for women. Peter highlights the benefits of light movement after meals and offers strength training tips for those managing injuries. Additional insights include how to maintain fat loss, the truth about so-called “slow metabolisms,” and how to set appropriate daily protein goals while managing the trade-off between lean mass and body fat over time. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #73 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Overview of episode topics on brain health, cardiovascular training strategies, and body composition [2:15]; Understanding dementia risk: modifiable vs. non-modifiable contributors to cognitive decline [5:00]; The causality between metabolic health and dementia [9:45]; How diet and exercise influence brain health: energy balance and exercise as key preventative tools [13:30]; Why combining aerobic, resistance, and cognitively engaging activities offers the most comprehensive benefits for preventing cognitive decline [17:00]; Additional lifestyle factors that influence dementia risk: smoking, head trauma, alcohol, and sleep [19:45]; The link between hearing loss and dementia: dose-dependent risk and the case for correction [25:15]; How poor oral hygiene may contribute to neuroinflammation and dementia risk [27:30]; Supplements for brain health: which ones matter and when they're worth considering [28:45]; Low LDL cholesterol and brain health: debunking the myth of cognitive risk [33:45]; How to approach zone 2 training: the importance of staying in zone 2 and tailoring intensity based on your time and goals [38:00]; Lactate testing for zone 2: clinical protocols and at-home approaches [43:00]; Combining modalities in zone 2 training: balancing enjoyment and efficiency [47:00]; Zone 2 training for women: addressing the misconception that zone 2 training is unnecessary or ineffective for postmenopausal women [49:30]; Effective strategies for VO₂ max training: short vs. long intervals [51:45]; The benefits of post-meal walking for glucose management, and why spikes in glucose during exercise aren't harmful [56:45]; The role of stability training in supporting resistance work and healthy aging [1:00:15]; Adapting strength training to manage chronic back injuries and train for longevity [1:02:00]; The role of aerobic exercise (like zone 2) in fat loss, metabolic health, and weight maintenance [1:06:30]; Debunking the “fast vs. slow metabolism” myth: why energy balance and protein matter most for fat loss [1:09:45]; Lean mass vs. body fat: why both matter for health and longevity [1:12:15]; How protein intake impacts muscle mass and why pairing it with resistance training is significantly more effective [1:15:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

On this episode of Critical Care Time, Nick & Cyrus embark on a deep dive into the world of lactic acidosis! As it is the beginning of the academic year, we figured this would be a great topic to demystify and disambiguate for our listeners. We discuss why lactic acidosis matters, and deconstruct all the clinically relevant elements from diagnosis to management, so that you are fully equipped with the tools necessary to conquer your next case of lactic acidosis - or maybe your first!! Ring in this new season of CCT with a banger of an episode and let us know what you think! Hosted on Acast. See acast.com/privacy for more information.

Every other week I'm republishing one of my most popular or impactful episodes and adding an update, new insight, or context that will help you benefit from it even more. This week I'm highlighting Episode 167, which discusses non-sepsis reasons for an elevated lactate. It's an important reminder not to get tunnel vision and think that every elevated lactate level means the patient has an overwhelming infection. In fact, some of these reasons may surprise you! Full Transcript – Read the article and view references FREE CLASS – If all you've heard are nursing school horror stories, then you need this class! Join me in this on-demand session where I dispel all those nursing school myths and show you that YES…you can thrive in nursing school without it taking over your life! Study Sesh – Change the way you study with this private podcast that includes dynamic audio formats that help you review and test your recall of important nursing concepts on-the-go. Free yourself from your desk with Study Sesh!  Med Surg Solution – Are you looking for a more effective way to learn Med Surg? Enroll in Med Surg Solution and get lessons on 57 key topics and out-of-this-world study guides. 

You've probably heard of HIIT—but have you heard of “REHIT?” This isn't just another workout trend...it's a new science-backed way to train with maximum efficiency and zero wasted time. If you're still jogging, you're wasting hours for minimal results. In this episode of The Human Upgrade, Dave Asprey sits down with Ulrich Dempfle, German-trained engineer and co-founder of CAROL Bike, to dismantle outdated cardio advice and introduce the 5-minute protocol that's obliterating fitness myths. Forget the treadmill grind. REHIT (Reduced Exertion High-Intensity Training) exercising delivers: • 12% VO₂ max increase • 6x the fitness gains of daily jogging • 62% drop in diabetes risk • 5x more BDNF for brain power —all with just 8 minutes of effort per week. But what is it? Ulrich unpacks the hard data, crushes the Zone 2 obsession, and shows exactly how a brand-new way of exercising is giving explosive results—no matter your age or fitness level. What You'll Learn in This Episode: • Why Zone 2 cardio is outdated advice for most people • The science of REHIT and how 2 sprints beat 2-hour workouts • The shocking data on VO₂ max, insulin sensitivity, and lifespan • How CAROL uses AI to personalize exercise for any age or ability • Why most people fail at fitness—and how to fix it • The real role of lactate, BDNF, and HRV in recovery and resilience • How perimenopausal women benefit more from REHIT than HIIT or jogging • Why adherence—not intensity—is the #1 predictor of results • What to do when you're traveling or don't have access to the tech Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • CAROL Bike Website and use code ‘DAVE' for a discount – https://carolbike.com/ • CAROL Bike Instagram - https://www.instagram.com/thecarolbike/?hl=en • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Introduction to REHIT Training • 00:24 Meet Ulrich Dempfle: The Mind Behind CAROL Bike • 00:51 The Science and Benefits of REHIT • 01:44 Comparing Traditional Cardio to REHIT • 02:32 Dave Asprey's Personal Fitness Journey • 03:43 The Efficiency of REHIT Training • 05:03 Practical Applications and Accessibility of REHIT • 08:22 Addressing Common Concerns and Misconceptions • 11:25 The Future of Fitness: REHIT and Beyond • 18:29 Scientific Validation and Real-World Results • 31:53 Clinical Trials and Tech Integration • 32:06 Upgrade Labs and CAROL Bike • 33:00 Mitochondrial Effectiveness and Insulin Sensitivity • 36:05 Zone Two Training vs. High-Intensity Training • 42:02 REHIT for Perimenopausal Women • 48:18 AI and Personalized Exercise • 57:52 Lactate and Exercise Benefits • 01:01:48 Interval Walking Training • 01:04:01 Conclusion and Future Insights See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You've probably heard of HIIT—but have you heard of “REHIT?” This isn't just another workout trend...it's a new science-backed way to train with maximum efficiency and zero wasted time. If you're still jogging, you're wasting hours for minimal results. In this episode of The Human Upgrade, Dave Asprey sits down with Ulrich Dempfle, German-trained engineer and co-founder of CAROL Bike, to dismantle outdated cardio advice and introduce the 5-minute protocol that's obliterating fitness myths. Forget the treadmill grind. REHIT (Reduced Exertion High-Intensity Training) exercising delivers: • 12% VO₂ max increase• 6x the fitness gains of daily jogging • 62% drop in diabetes risk • 5x more BDNF for brain power —all with just 8 minutes of effort per week. But was it? Ulrich unpacks the hard data, crushes the Zone 2 obsession, and shows how a brand-new way of exercising is giving explosive results—no matter your age or fitness level. What You'll Learn in This Episode: • Why Zone 2 cardio is outdated advice for most people • The science of REHIT and how 2 sprints beat 2-hour workouts • The shocking data on VO₂ max, insulin sensitivity, and lifespan • How CAROL uses AI to personalize exercise for any age or ability • Why most people fail at fitness—and how to fix it • The real role of lactate, BDNF, and HRV in recovery and resilience • How perimenopausal women benefit more from REHIT than HIIT or jogging • Why adherence—not intensity—is the #1 predictor of results • What to do when you're traveling or don't have access to the tech Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • CAROL Bike Website and use code ‘DAVE' for a discount – https://carolbike.com/ • CAROL Bike Instagram - https://www.instagram.com/thecarolbike/?hl=en • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Introduction to REHIT Training • 00:24 Meet Ulrich Dempfle: The Mind Behind CAROL Bike • 00:51 The Science and Benefits of REHIT • 01:44 Comparing Traditional Cardio to REHIT • 02:32 Dave Asprey's Personal Fitness Journey • 03:43 The Efficiency of REHIT Training • 05:03 Practical Applications and Accessibility of REHIT • 08:22 Addressing Common Concerns and Misconceptions • 11:25 The Future of Fitness: REHIT and Beyond • 18:29 Scientific Validation and Real-World Results • 31:53 Clinical Trials and Tech Integration • 32:06 Upgrade Labs and CAROL Bike • 33:00 Mitochondrial Effectiveness and Insulin Sensitivity • 36:05 Zone Two Training vs. High-Intensity Training • 42:02 REHIT for Perimenopausal Women • 48:18 AI and Personalized Exercise • 57:52 Lactate and Exercise Benefits • 01:01:48 Interval Walking Training • 01:04:01 Conclusion and Future Insights See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, I discuss how different forms of exercise impact brain health and performance in both the short and long term. I explain how many of the positive effects of exercise on brain function occur through the action of specific neurochemicals that increase alertness. I also cover how to best time exercise and which specific types of exercise to include in your weekly routine to maximize benefits for your brain. Additionally, I explain how certain types of exercise trigger the release of a hormone from your bones called osteocalcin, as well as brain-derived neurotrophic factor. Together, these substances increase neuroplasticity and enhance learning. The positive effects of exercise on brain oxygenation, blood supply, and fuel utilization are also discussed. Listeners will learn how to design a weekly exercise program that optimizes physical fitness, brain health, longevity, and performance, along with the mechanistic logic behind those recommendations. Find show notes with articles, resources and more at hubermanlab.com. Pre-order Andrew's upcoming book, Protocols: https://go.hubermanlab.com/protocols Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman David: https://davidprotein.com/huberman Function: https://functionhealth.com/huberman Maui Nui: https://mauinui.com/huberman Timestamps 00:00:00 Exercise, Brain Health & Performance; Protocols Book 00:04:03 Sponsors: BetterHelp & Helix Sleep 00:06:55 Brain Health, Cardiovascular & Resistance Training 00:11:51 Exercise & Positive Impact on Brain Performance; Arousal 00:18:20 Learning & Arousal 00:23:18 Sponsors: AG1 & David 00:26:01 Exercise & Acute Learning 00:29:16 Tool: High-Intensity Training & Cognitive Flexibility; Over-Training 00:33:32 Long-Term Brain Health; Tool: Exercise “Snacks”, Cognitive Performance 00:36:57 Exercise, Brain & Body Energy, Adrenaline, Norepinephrine 00:44:08 Adrenal “Burnout”?; Exercise to Increase Energy, Adrenaline 00:48:20 Tool: Core, Compound Movements; Mind-Body Connection 00:53:58 Sponsor: Function 00:55:45 Bones, Osteocalcin, BDNF & Hippocampus; Tool: Jump Training 01:01:30 Exercise, Fuel, Multifactorial Pathways; BDNF & Activity 01:05:06 Lactate, Astrocytes & Brain Function; VEGF & Brain Health 01:11:17 Tools: Zone 2, High-Intensity Training, Time Under Tension Training 01:19:54 Sponsor: Maui Nui 01:21:37 Tools: Time Under Tension; Explosive Jumping, Eccentric Control Training 01:25:30 Injury & Exercise, Illness 01:28:09 Sleep; Injury, Sleep-Deprivation & Exercise 01:33:51 SuperAgers, Anterior Mid-Cingulate Cortex, Grit & Persistence 01:42:04 Tool: Embrace Challenges; Deliberate Cold Exposure, Rope Flow 01:47:39 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures