Podcasts about hba1c

Dr. Sunil Gupta highlighted that insulin remains the most effective and life-saving treatment for diabetes, especially when oral medications fail. He explained that many people with Type 2 diabetes eventually require insulin, and delaying its initiation can lead to serious complications such as neuropathy, retinopathy, kidney disease, heart disease and diabetic foot problems. Addressing common fears, he clarified that modern insulin pens are almost painless and newer insulin analogues closely mimic natural insulin action, significantly reducing the risk of hypoglycaemia, particularly at night. He stressed the importance of regular blood sugar monitoring, HbA1c testing and annual health check-ups after 30 years of age, noting that many individuals with diabetes may remain asymptomatic. He also drew attention to insulin-requiring diabetes in undernourished adults in India and the need for timely specialist referral. Kavita Gupta emphasized healthy dietary practices, explaining why whole fruits are better than fruit juices due to fiber and lower glycaemic index. She advised consuming low-GI foods and shared practical tips to prevent hypoglycaemia through timely meals and planned nutrition, especially for children, the elderly, and physically active individuals. Expert- Dr Sunil Gupta & Dr Kavita Gupta Anchor- Mrs. Shraddha Bharadwaj Podcast: 10/05/2019 Recorded at: Akashwani Nagpur     Episode: 99

Dr. Sunil Gupta explained the complications of diabetes in simple and easily understandable language, highlighting the serious consequences of long-term uncontrolled blood sugar. He stated that persistent hyperglycaemia leads to microvascular complications such as diabetic neuropathy, retinopathy, and nephropathy, while major events like heart attack, stroke, and gangrene are associated with diseases of the large blood vessels. He described early symptoms of diabetic neuropathy, including burning sensation, numbness, tingling, and pain in the feet, and urged patients not to ignore these warning signs. Dr. Gupta clearly emphasized that diabetes control cannot be achieved by medicines alone. He stressed the importance of regular monitoring of blood glucose, HbA1c, blood pressure, cholesterol, and vitamin levels, along with avoiding wide fluctuations in blood sugar levels. He described insulin as the safest and most effective treatment for diabetes and cautioned that unnecessary delay in initiating insulin therapy can significantly increase the risk of complications. He also emphasized that before managing gangrene or planning surgery, strict control of blood sugar, blood pressure, and cholesterol, along with regular walking, quitting smoking and tobacco use, avoiding alcohol, and maintaining a disciplined lifestyle, are extremely important to improve outcomes and prevent limb loss. Expert- Dr Sunil Gupta Anchor- Mrs. Purva Kulkarni Podcast: 12/12/2025 Recorded at: Akashwani Nagpur     Episode:100

This episode covers: • Trump Drug Pricing Deals and Access to Longevity Medications New drug-pricing agreements announced under President Donald Trump aim to lower the cost of high-priced prescription drugs through negotiated rebates and pricing pressure on major pharmaceutical companies. Early reporting suggests these changes could affect cardiometabolic and longevity-relevant medications, including GLP-1 diabetes and obesity drugs. Dave explains why the real question is not headline savings, but whether lower prices actually reach patients at the pharmacy counter. He breaks down how affordability shapes real-world access, adherence, and long-term prevention strategies, and why policy decisions can matter more than new mechanisms when it comes to sustainable longevity care. Source: https://longevity.technology/news/trump-sets-new-drug-pricing-deals-with-big-pharma/ • 5:2 Intermittent Fasting Outperforms Daily Dieting on Metabolic Health A controlled study compared three popular strategies in people with obesity and type 2 diabetes: 5:2 intermittent fasting, time-restricted eating, and continuous daily calorie restriction. All approaches improved weight and HbA1c, but the 5:2 protocol produced larger reductions in fasting glucose, triglycerides, and insulin resistance. Dave explains why periodic restriction can outperform constant dieting, how to structure fasting days without tanking performance, and how to pair intermittent fasting with CGM data and training schedules for better metabolic flexibility and long-term health. Source: https://www.sciencedaily.com/releases/2025/07/250715043351.htm Full paper: https://www.nature.com/articles/s41598-025-32673-9 • Cocoa's Theobromine Linked to Slower Epigenetic Aging New research highlighted by Aging-US suggests that theobromine, a bioactive compound found in cocoa, is associated with epigenetic markers of slower biological aging. Dave breaks down what epigenetic aging clocks actually measure, why this finding adds credibility to cocoa's cardiometabolic benefits, and why most chocolate products cancel out the upside with sugar and ultra-processing. He explains how to think about food-derived bioactives without turning them into hype-driven anti-aging shortcuts. Source: https://www.aging-us.com/news-room/theobromine-from-cocoa-linked-to-slower-biological-aging • Organ-Specific Biological Age Clocks Predict Disease Risk More Accurately A large Nature study built biological aging clocks for individual organs using blood-based proteomics, showing that organ-specific aging predicts disease and mortality better than a single “bio age” number. Dave explains why you can be biologically young overall but still have an aging brain, arteries, or kidneys, and how this reframes longevity from generic anti-aging to targeted organ protection. He explores how sleep, blood pressure, glucose control, and exercise map differently to different organs, and why precision aging metrics are the future of prevention. Source: https://www.nature.com/articles/s43587-025-01016-8 • Copper Peptides and the Rise of Skin Longevity Copper peptides like GHK-Cu are moving from niche skincare into serious longevity conversations. Human data show strong effects on collagen synthesis, barrier repair, and wound healing, in some cases outperforming traditional retinoids. Dave explains why skin is not just cosmetic but a key immune and environmental interface, how copper peptides fit into repair-focused protocols, and why cycling repair and stress mirrors smarter approaches to training and recovery across the body. Source: https://www.vogue.com/article/copper-peptides Auro Wellness Copper Peptide with Discount (click on skincare and scroll to Copper Peptide): https://aurowellness.com/pages/dave All source links provided for direct access to the original research and reporting. This episode is designed for biohackers, longevity seekers, and high-performance listeners who want practical strategies grounded in real science and real-world constraints. Dave Asprey translates emerging research, policy shifts, and clinical data into actionable upgrades for metabolism, fasting, biological age tracking, skin health, and long-term prevention. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: Trump drug pricing deals, prescription drug affordability, GLP-1 access, cardiometabolic medications, longevity policy, intermittent fasting 5:2, intermittent energy restriction, time restricted eating study, insulin sensitivity improvement, metabolic flexibility fasting, theobromine cocoa aging, epigenetic aging markers, biological age clocks, organ specific aging, proteomics longevity research, brain age dementia risk, vascular aging, copper peptides GHK-Cu, skin longevity protocols, collagen synthesis skincare, evidence-based biohacking news, longevity science updates Thank you to our sponsors! - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. -Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body's really doing behind the surface. Resources: • Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer0:19 - Story 1: Trump's Drug Price Deals 2:33 - Story 2: Fasting Reality Check 4:35 - Story 3: Chocolate and Biological Age 6:11 - Substack Update7:30 - Story 4: Organ-Specific Aging 9:05 - Story 5: Copper Peptides for Skin 11:02 - Weekly Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This conversation covers a range of topics related to health, nutrition, and dietary practices, focusing on hydration, sodium intake, autoimmune conditions, and the implications of various diets such as keto and carnivore. The speakers discuss the importance of protein, the role of metabolic flexibility, and the nuances of interpreting health metrics like HbA1c and CAC scores. They also emphasise community engagement and the value of educational resources for a better understanding of the dietary impacts on health.Chapters00:00 Q&A and Practical Advice01:38 The Sodium Paradox: Understanding Sodium Intake and Health04:40 Dietary Strategies for Autoimmune Conditions07:40 Exploring the Benefits of Carnivore Diets09:41 Understanding HbA1c and Its Implications13:23 Nutritional Protocols and Their Efficacy15:55 Metabolic Flexibility: The Body's Energy Regulation17:47 Cortisol and Leptin: Hormonal Balance in Health19:04 The Role of Protein in Diets22:26 Evaluating CAC Scores and Dietary Impact25:35 Community Engagement and Learning Opportunities

This episode covers: • FDA Loosens Supplement Warning Labels The FDA is considering a rule change that would allow supplement companies to include the DSHEA disclaimer only once per package rather than next to every claim. Dave explains why fewer visible warnings could make marketing look more like medical claims, and why biohackers should treat labels as advertising rather than evidence. He shares how to protect yourself now: add one variable at a time, run baseline labs, and rely on data instead of packaging. Source: https://www.nbcnews.com/health/health-news/fda-supplements-warning-label-rule-change-rfk-jr-rcna249321 • Quantum Sensors for Early Heart Attack Detection Mayo Clinic is testing a contactless heart-monitoring system called CardiAQ using quantum magnetic sensors and AI noise filtering. The device reads subtle electromagnetic signatures from the heart and compares them to invasive angiography. Dave breaks down why earlier detection of ischemia could shift heart care from reactive treatment to proactive screening — and why building baseline metrics like VO₂max, blood pressure and HRV today will pay off when next-gen diagnostics arrive. Source: https://www.sandboxaq.com/press/sandboxaq-collaborates-with-mayo-clinic-on-novel-cardiac-diagnostics • Sauna Detox for MicroplasticsEmerging research shows that sweating meaningfully removes plastic-related chemicals like BPA and phthalate metabolites from the body, often more efficiently than blood or urine alone. Sauna use amplifies this effect by increasing circulation, mobilizing stored toxins from tissues, and accelerating sweat-based excretion. When you combine regular heat exposure with reduced environmental plastic contact, you create a powerful detox strategy that targets a chemical burden once thought unavoidable. Dave breaks down how sauna protocols can support toxin elimination, improve cardiovascular resilience, strengthen autonomic balance, and help counteract the metabolic and hormonal disruptions linked to microplastics in modern life.Source: https://superage.com/can-you-sweat-out-microplastics-in-the-sauna/ • Psychedelics and Longevity Biomarkers Bryan Johnson treated a guided psilocybin experience as a structured longevity experiment, collecting nearly 250 biomarkers including CGM, stress markers, HRV and Kernel brain imaging. The experiment revealed a surprising metabolic change: mean glucose dropped 8 percent, variability fell 11 percent, and estimated HbA1c moved from 4.7 to 4.4 — similar to months of metformin but after a single session. Dave explores the emerging idea that neuroplastic events might influence glucose regulation through brain-pancreas signaling, while emphasizing the need for supervised, legal use and proper clinical trials. Source: https://www.businessinsider.com/bryan-johnson-trip-on-mushrooms-five-hours-live-2025-12 • A Mitochondrial Protein that Extends Mouse Lifespan Researchers boosted the mitochondrial protein COX7RP and extended mouse lifespan by ~6.6 percent while improving insulin sensitivity, lipid handling, endurance and liver fat metabolism. COX7RP supports formation of mitochondrial “supercomplexes,” improving respiratory efficiency and ATP generation. Dave explains how this reinforces lifestyle levers — strength training, aerobic capacity, stabilizing blood sugar — as tools that likely preserve supercomplex architecture and mitochondrial resilience. Source: https://www.eurekalert.org/news-releases/1109082 All source links provided for direct access to the original research and reporting. This episode is designed for biohackers, longevity seekers and high-performance listeners who want practical strategies rooted in cutting-edge science. Dave Asprey translates emerging research into actionable upgrades for your biology — from metabolism and mitochondria to nervous system health, detox, and prevention. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: FDA supplement rule change, supplement warning labels, DSHEA disclaimer removal, supplement regulation risks, quantum cardiac scanner, Mayo Clinic heart attack detection, AI heart monitoring, early ischemia detection technology, sauna detox evidence, sweating out toxins research, BPA phthalate sweat studies, microplastics sauna myth, Bryan Johnson psilocybin experiment, psychedelic longevity research, psychedelic metabolic reset, glucose control psychedelics, HbA1c psilocybin results, continuous glucose monitor insights, mitochondria lifespan research, COX7RP protein aging study, mitochondrial supercomplex benefits, ATP energy output aging, metabolic flexibility longevity, biohacking news update, anti-aging science breakthroughs, evidence-based longevity tools, biological age biomarkers Thank you to our sponsors! -BEYOND Conference 2026 | Register now at https://beyondconference.com/ -BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. Resources: • Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Intro 0:18 - Story 1: FDA Supplement Label Changes 1:43 - Story 2: CardiAQ Heart Scanner 2:59 - Story 3: Saunas and Microplastics 4:58 - Story 4: Psychedelics and Blood Sugar 8:22 - Story 5: Mitochondrial Longevity Research 10:29 - Weekly Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this powerful and paradigm-shifting conversation, Darin Olien sits down with Dr. Mindy Pelz to dismantle everything we've been told about menopause, hormones, aging, and women's power. This is not a conversation about "fixing" women — it's about understanding a profound neurological, biological, and evolutionary transition that has been misunderstood, pathologized, and silenced for decades. Together, they explore why menopause is not the end of vitality, but the beginning of leadership, clarity, and sovereignty — and why reclaiming this transition could fundamentally reshape families, culture, and the future of women's health.     What You'll Learn (with Full Timecodes) 00:00:00 – Welcome to SuperLife: Why this episode matters for everyone, not just women 00:01:05 – The hidden cost of modern living: Plastics, endocrine disruption, and invisible hormonal stress 00:02:47 – Introducing Dr. Mindy Pelz: Why this conversation goes deeper than anything online 00:03:17 – Why women were excluded from medical research for decades 00:05:26 – The shocking pattern Dr. Pelz saw in women in their 40s: When life looks perfect but feels unbearable 00:06:41 – The suicide and divorce statistics no one talks about 00:07:27 – Why menopause exists at all: The evolutionary mystery 00:08:55 – The Grandmother Hypothesis: Why post-menopausal women kept humanity alive 00:10:08 – The brain shift that makes women stop people-pleasing 00:11:31 – Aging, fear, and the cultural erasure of women's wisdom 00:13:10 – The female brain before vs. after menopause 00:15:13 – Darin's reflection on his mother and invisible female labor 00:16:06 – Why community, safety, and oxytocin matter more than willpower 00:18:00 – Carol Gilligan's research: When girls stop knowing what they want 00:19:32 – Menopause as an awakening — not a breakdown 00:21:24 – Why men must be part of this conversation 00:22:26 – Leadership, aging, and reclaiming relevance 00:24:18 – Family dynamics when identity shifts 00:25:33 – The problem with outsourcing menopause to hormone therapy alone 00:27:00 – How to communicate needs without blame or collapse 00:30:07 – Metabolic health, insulin resistance, and early menopause 00:31:16 – The one blood marker every woman over 40 must track (HbA1c) 00:34:45 – The Hormonal Hierarchy explained: Cortisol, insulin, sex hormones, oxytocin 00:37:44 – Menopause as a cultural rite of passage we never created 00:39:31 – Dementia, Alzheimer's, and the glucose-starved brain 00:40:23 – Why fasting is neuroprotective for women 00:42:35 – How fasting helps menopausal belly weight 00:44:36 – Why shame keeps women disconnected from their power 00:45:34 – Why puberty and menopause are happening earlier 00:46:21 – Big Pharma, fear narratives, and the HRT conversation 00:48:35 – Empowerment vs. outsourcing health 00:50:11 – Why society fears powerful, post-menopausal women 00:52:11 – Dr. Pelz's personal breaking point and nervous system reset 00:55:33 – Redefining work, marriage, and self-permission 00:58:37 – Resentment as a diagnostic tool 01:01:15 – Neuroplasticity, obstacles, and the hero's journey 01:03:16 – Why going through discomfort rewires the brain 01:04:23 – Integration: Menopause as rebirth, leadership, and collective healing 01:12:25 – Closing reflections and final takeaways     Thank You to Our Sponsors: Therasage: Go to www.therasage.com and use code DARIN at checkout for 15% off Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order Caldera Lab: Experience the clinically proven benefits of Caldera Lab's clean skincare regimen and enjoy 20% off your order by visiting calderalab.com/darin and using code DARIN at checkout.     Join the SuperLife Community Get Darin's deeper wellness breakdowns — beyond social media restrictions: Weekly voice notes Ingredient deep dives Wellness challenges Energy + consciousness tools Community accountability Extended episodes Join for $7.49/month → https://patreon.com/darinolien     Find More From Dr. Mindy Pelz: Website: drmindypelz.com Instagram: @dr.mindypelz Follow her YouTube Channel Podcast: The Resetter Podcast Order her new book: Age Like a Girl     Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Website: https://superlife.com Book: Fatal Conveniences     Key Takeaway: Menopause isn't a failure of the female body — it's the moment a woman's brain rewires for truth, leadership, and independence. When we stop trying to fix women and start understanding this transition, we don't just heal individuals — we change families, cultures, and the future.  

Program notes:0:37 Breast density knowledge outcomes1:37 Breast density notification and education2:37 Can't assess the import individually3:30 CV outcomes with tirzepatide4:30 HbA1c 8.45:30 GLP-1s have many benefits6:30 No difference in adverse events7:10 Covid vaccination in pregnancy8:10 20K women included9:10 Initial benefit is it durable?9:30 Complex regional pain syndrome treatment10:30 Using bisphosphonates for treatment11:33 Even light contact causes severe pain12:28 End

A long-term analysis of major prediabetes trials found that achieving remission or returning glucose levels to normal was associated with over a 50% reduction in cardiovascular death or heart failure, with durable benefits decades later; delaying diabetes without remission did not show similar benefit. A randomized trial in critically ill adults found no difference in 28-day mortality between ketamine and etomidate for intubation, though ketamine increased the risk of cardiovascular collapse. Finally, molecular data showed indoor tanning causes widespread DNA mutations linked to melanoma, reinforcing its carcinogenic risk.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter tackles a wide-ranging set of listener questions spanning lifespan interventions, exercise, cardiovascular risk reduction, time-restricted eating, blood pressure management, hormone therapy, diagnostics, and more. Peter reveals the single most important lever for extending healthspan and lifespan, and explains how he motivates midlife patients using the Centenarian Decathlon framework. He discusses the importance of addressing high apoB and cholesterol even in metabolically healthy individuals with calcium scores of zero, how to manage high blood pressure, and how to accurately evaluate metabolic health beyond HbA1c. Additional topics include time-restricted eating, practical considerations around ultra-processed foods, nuanced approaches to HRT for women and TRT for men, and why early and expanded screening for chronic disease—colonoscopy, PSA, coronary imaging, low-dose CT—can be lifesaving. He also offers insights into treating prediabetes, crafting exercise programs for those short on time, and safely incorporating high-intensity training in older adults. If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #78 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: Introducing a wide-ranging AMA: practical perspectives on lifespan interventions, metabolic health, diet, hormones, diagnostics, and more [2:45]; Why exercise is the most powerful single intervention for lifespan and healthspan [4:15]; How Peter motivates midlife patients to prioritize exercise [6:00]; Why lifespan and healthspan should not be treated as competing priorities and how choosing sustainable interventions benefits both [9:30]; Why high apoB deserves treatment even in a metabolically healthy patient with a CAC score of zero [14:00]; Managing hypertension: ideal targets for blood pressure, lifestyle levers, and why early pharmacology matters [18:15]; Assessing metabolic health beyond HbA1c: fasting insulin, triglycerides, lactate, zone 2, and more [23:30]; How to avoid common self-sabotaging patterns by choosing sustainable habits over extreme health interventions [26:00]; Time-restricted eating: minimal effect beyond calorie control, implications for protein intake, and practical considerations for implementing it [28:00]; Ultra-processed foods: definitions, real-world risks, and practical guidelines for smarter consumption [30:30]; How women should prepare for menopause and think about hormone replacement therapy: early planning, symptom awareness, and guidance on HRT [36:45]; Testosterone replacement for aging men: indications, benefits, and safe clinical management [39:45]; Why Peter recommends earlier and more aggressive screening tests than guidelines suggest: colonoscopies, coronary imaging, PSA, Lp(a), and low-dose CT scans, and more [43:30]; Full-body MRI screening: benefits, limitations, potential false positives, and the importance of physician oversight [47:15]; Prediabetes: individualized treatment strategies using tailored combinations of nutrition, sleep, and training interventions [51:00]; Time-efficient training plans for people with only 30 minutes per day to exercise [53:00]; How to safely introduce high-intensity exercise for older adults [55:00]; Timed dead hangs and ripping phone books: a playful look at Peter's early attempts to impress his wife [57:15]; Peter's carve out: The Four Kings documentary about a golden era of boxing [1:01:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

What if you thought you were doing the right things and invincible, and then…a heart attack happens? That's exactly what my guest Cindy experienced. She had been trying to eat ‘clean keto' and was feeling she had more energy with weight loss, and then a heart attack came out of the blue. That's how her life as she knew it, changed when she came out of the surgery room and was prescribed 5 meds.   Join me in this episode as we hear of Cindy's plant-based diet journey, the changes she experienced and her key piece of takeaway advice for those wanting to start or continue eating plant-based. The best part? I followed up with Cindy and two years later eating plant-based, she has come off of nearly all her meds and her HbA1c level is even lower!     Contact -> healthnow@plantnourished.com Learn -> www.plantnourished.com Join -> Plant-Powered Life Transformation Course: www.plantnourished.com/ppltcourse Connect with Community -> www.facebook.com/groups/beginnerplantbaseddietsuccess Get Free 15-Minute Strategy Call -> www.plantnourished.com/strategycall Free Resource -> Quick Start Grocery Guide for Plant-Based Essentials: www.plantnourished.com/groceryguide     Have a question about plant-based diets that you would like answered on the Plant Based Eating Made Easy Podcast? Send it by email (healthnow@plantnourished.com) or submit it by a voice message here: www.speakpipe.com/plantnourished       [Plantbased Eating, Plant Based, Heart Attack, Blood Sugars, Blood Glucose Control, Prediabetes, Diabetes, Keto, Plantbased Transition, Heart Health, Heart Disease, Weight Loss, Whole Foods, Lose Weight, Drop Pounds]

In Deutschland leben etwa 9 Millionen Menschen mit einem diagnostizierten Typ-2-Diabetes. Jedes Jahr kommen ca. 450.000 Patientinnen und Patienten neu dazu: Die Belastung des Gesundheitssystems wird aller Voraussicht nach in den kommenden Jahren zunehmen. Bei vielen Betroffenen mit Diabetes mellitus treten zeitgleich Komorbiditäten auf, darunter oft kardiovaskuläre Erkrankungen bzw. chronische Nierenkrankheit. Man spricht auch vom kardiorenal-metabolischen Syndrom.

Dr. Sunil Gupta advises that if blood sugar is well-controlled and only mild medications are used, fasting can be observed safely. However, during fasting, one should consume light diets such as milk, fruits, or bhagar at intervals to prevent hypoglycemia. A frequent craving for sweets may indicate prediabetes, as excessive intake can overwork pancreatic beta cells and eventually lead to diabetes. Dr. Gupta explains that insulin in the body functions in two forms — basal insulin, which works continuously 24×7, and bolus insulin, which is secreted by beta cells in response to meals. For Type 1 diabetes, research on pancreatic or beta cell transplants, stem cell therapy etc. are ongoing, though a permanent cure remains under study. The HbA1c target should ideally remain between 6.5–7, though elderly patients may maintain slightly higher levels for safety. (may be 7.5% or 8%) While traveling, always carry insulin, medications, glucose tablets, and a diabetes identity card in your hand luggage. During festivals, treat prasad as a symbol of devotion rather than a food portion. Avoid excess sweets, stay active, and extra parikrama may be practiced as a healthy form of exercise. Expert- Dr Sunil Gupta   Anchor- Mrs. Shraddha Bharadwaj     Podcast: 23/08/2019 Recorded at: Akashwani Nagpur     Episode: 95

N524 - EASD 2025 - Redução de HBA1C e Peso: Os achados do SURPASS-PEDS em adolescentes - Fernando Valente by SBD

N473 - EASD 2025 - Semaglutida Oral no Soul: Maior benefício CV com HBA1C 8% - Dhiãnah Santini e Luciano Albuquerque by SBD

N523 - EASD 2025 - SURPASS-PEDS: Tirzepatida reduz HBA1C e peso em adolescentes com diabetes tipo 2! - Flávia Coimbra, Karen de Marca e Fernando Valente by SBD

Everyone seems to be chasing the secret to living longer these days, from cold plunges and stem cells to full body scans and biohacking routines. But as I sat with the image of those two 75-year-old men, one walking, laughing and playing with his grandchildren, the other struggling to get out of bed, I realised longevity is about far more than simply adding years. It's about whether those extra years are spent in hospital beds or in cafés with friends. The real question isn't “How long can we live?” but “How well can we live for as long as we're here?”In this episode of The Wellness Algorithm, we are joined by Dr Darshan Shah, a surgeon, entrepreneur, longevity expert and founder of Next Health. Together, we explore what it really means to age gracefully, why healthspan matters more than lifespan, and how much of our future health is truly within our control. We talk about whether you can overcome a difficult genetic history, the difference between living longer and living better, and how modern tools such as blood biomarkers, wearables, CT angiograms and full body MRI allow us to detect disease years before it appears as a crisis.To help you start your own data-led wellness journey, here are some of the core tests and metrics Dr Shah recommends for personalised health insights:Metabolic Health Tests: Blood sugar, insulin, HbA1c, full lipid profile, blood pressure, waist circumference, body fat percentage and visceral fat.Hormonal & Functional Health Tests: Key hormone markers, gut-health indicators, detoxification markers.Inflammation & Ageing Markers: Tests that measure systemic inflammation and biological ageing.Gut Health Tests: Microbiome analysis and food-sensitivity or leaky-gut testing.Wearable Metrics: Heart-rate variability, sleep tracking, smart-scale body composition and continuous glucose monitoring.Alziemer's disease: Blood biomarkers testThis episode isn't about chasing eternal youth; it's about understanding your body more deeply so you can age with clarity, confidence and strength. You'll walk away with a renewed sense of how everyday choices shape your energy, resilience and long-term health, along with simple tools you can start using now to feel better from the inside out.For a transcript of this show, go to https://wellnesscurated.life/future-of-longevity-can-we-really-reverse-ageing/Leave a review

Blutwerte sind der Gesundheitskompass des Körpers. Jonas Köller erklärt, welche Werte wirklich zählen, warum das „große Blutbild“ überschätzt wird und wie du gefährliche Mängel früh erkennst. Von LDL über HbA1c bis Vitamin D: So liest du deinen Körper wie ein offenes Buch.

Topics We Cover: 00:00 – New data from Harvard/Mass General may classify nearly 70% of adults as having obesity 03:00 – A new oral triple agonist shows record-setting absorption rates 07:00 – Fractal Health's Revita procedure: weight maintenance after stopping GLP-1s 12:00 – Zepbound vial prices drop (full breakdown by dose) 16:00 – Dave's personal experience switching off Mounjaro and intense hunger return 22:00 – Novo Nordisk's EVOKE/EVOKE+ Alzheimer's trial: what the data really means 29:00 – Why GLP-1 neurological research is just getting started 33:00 – Updates on access, partners, and major news coming soon for Medicare patients If you're on Wegovy, Mounjaro, Zepbound, Saxenda, Trulicity, or compounded versions, this episode gives you the insight and context you need to have more competent and confident conversations with your doctor. Bullet Point Summary of the Podcast Episode New Obesity Measurement Data (Harvard/Mass General Study) Harvard and Mass General propose adding waist circumference to BMI to better diagnose obesity. Traditional BMI misses key factors like muscle mass and body composition. Using the updated measure, Americans classified as obese jumps from ~43% to almost 69%. This means 7 out of 10 U.S. adults would now qualify as having the disease of obesity. Dave notes this validates many people who “feel” metabolically unwell despite a “normal” BMI. Reinforces his claim that “most people should be talking to their doctors about GLP-1s.” New Oral Triple Agonist (Ascletis – ASC41/ASC? Molecule) From Ascletis (A-S-C-L-E-T-I-S), developing an oral triple agonist targeting: GLP-1 GIP Glucagon Similar in mechanism to retatrutide, expected around 2027. Preclinical (animal) data show stunning results: Oral bioavailability of 4.2% 9× higher than tirzepatide 30× higher than oral semaglutide 6× higher than oral retatrutide 57× greater drug exposure than oral retatrutide Half-life ~56 hours Stronger receptor activation than retatrutide in vitro Suggests potential for the first powerful oral triple agonist—worth watching. ️ 3. Discussion of the Gray Market / TikTok Experience Dave briefly recounts losing his TikTok account and landing in an algorithm filled with teenagers promoting gray-market “retatrutide.” Expresses concern over unregulated peptide sales, especially to minors. Fractal Health's New Data – Weight Maintenance After Stopping GLP-1s New results from the Reveal One study (Fractal Health). Participants: lost 24% of body weight on GLP-1s → stopped injections → got one Revita procedure. At 6 months post-GLP-1 discontinuation: Weight changed only 1.5% (vs. ~10% regain in typical off-drug trials) HbA1c barely shifted Safety profile clean Suggests possible long-term weight maintenance without injections through gut mucosal re-lining. Dave describes his own recent attempt to switch drugs and significant hunger return. Food Noise & Biologic Hunger Dave discusses how stopping Mounjaro caused terrifying, primal hunger. Describes the distinction between: Food noise (brain-based thoughts) Hunger signals (biological/animalistic) Reinforces why many patients cannot maintain weight loss without support. Zepbound (Tirzepatide) Cash-Pay Price Reductions Eli Lilly drops cash-pay vial pricing: 2.5 mg: $349 → $299 5 mg: $499 → $399 7.5–15 mg: $499 → $449 Community feedback (informal poll): Most say still too high to leave compounded versions. Many would switch to branded if price hit $200–$300. Dave notes the Most Favored Nations agreement will push GLP-1 prices toward $250/month within 24 months. Alzheimer's Study (Novo Nordisk – EVOKE & EVOKE+) Oral semaglutide (Rybelsus, 14 mg) did not slow Alzheimer's clinical progression. Biomarkers improved but daily function and cognitive decline did not improve vs placebo. Important context: Oral Rybelsus is a weak form of semaglutide; stronger versions (like Wegovy 2.4 mg or upcoming high-dose oral Wegovy) not tested. Weight loss is not desirable in Alzheimer's patients, influencing drug selection. Dave emphasizes: This was a nearly $700M trial and an act of scientific courage. This is NOT the end of GLP-1 Alzheimer's research. Future molecules may target neurological pathways without suppressing appetite. Mentions Lilly's brenipatide, a GIP receptor agonist being developed for: Addiction Opioid dependency Possibly asthma ️ 8. Access, Cost, and Patient Empowerment Highlights Shed as a partner offering telehealth GLP-1 access. Notes many patients hide GLP-1 use from their primary care doctors. Reinforces OTP's mission: better, more honest conversations with clinicians. Shapa (Numberless Scale) & Dave's Personal Update Dave explains how the Shapa numberless scale helped him stay engaged during weight fluctuations. Finds stepping on “zones” (green/gray/blue) less emotionally damaging than numbers. Closing Notes Promises upcoming Eli Lilly savings card update. Encourages subscribing, liking, and enabling notifications for algorithm visibility. Thanks OTP community for amplifying patient-centric obesity medicine news. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

After more than 50 years of on-and-off dieting, Caroline felt like a “hopeless case” with food.In this episode of The Eating for You Podcast, she shares how dieting from her teens, living with type 2 diabetes, and constant self-criticism damaged her relationship with food—and how mindful eating has helped her find peace, confidence, and better health in her 60s.We talk about what it's really like to step away from diet rules, how to handle “missteps” without shame, and the small, practical changes that supported Caroline's HBA1c dropping into her recommended range. If you've ever felt that food is controlling you, or that you “should know better by now,” this conversation is for you.In this episode, you'll learn:How early dieting and body image worries can shape a lifetime of eating habitsWhy dieting left Caroline feeling like a failure—and how mindful eating changed thatThe role of stress, cortisol and self-talk in emotional and non-hunger eatingWhat it means to tune into hunger, fullness, satisfaction and food pleasure againPractical changes Caroline made (like timing sweets, breakfast, and adding legumes)How self-compassion and curiosity help you get back on track after a “misstep”Why focusing on daily habits—not the scales—can support long-term health markers like HBA1cIf you'd like to explore how mindful eating could support your own health and relationship with food, you're invited to book a free Mindful Eating Strategy Call with Sallyanne. You'll explore your challenges, your goals, and whether the Eating for You approach is the right next step for you. Book Here.

In this episode, Ben Azadi breaks down five science-backed metabolic drinks that naturally reduce arterial plaque, boost nitric oxide, lower inflammation, and support metabolic health — without medications or side effects. You'll learn: • Why arterial inflammation — not cholesterol — is the real silent killer• How pomegranate juice reversed arterial plaque by 30% in human studies• The surprising cardiovascular benefits of high-quality coffee with butter, olive oil, and salt• Why raw cacao improves arterial flexibility by up to 400% (Harvard study)• How apple cider vinegar and cinnamon lower fasting glucose, HbA1c, and triglycerides• The anti-inflammatory power of turmeric + black pepper and how it calms the arteries Ben also explains:• Which drink is best for diabetics• How to rotate the drinks weekly for maximum benefit• What markers to test before and after 30 days to measure progress (ApoB, CRP, fasting insulin, triglycerides, HDL, CAC score, and more) Plus, he shares a free guide revealing the five vegetables silently inflaming your gut and slowing your metabolism — and what to eat instead. A simple daily cup could dramatically upgrade your cardiovascular and metabolic health. FREE GUIDE: 5 Vegetables You Must Avoid To Lose Weight & Belly Fat - https://bit.ly/48CIprn

Episode 207: Understanding Hypertension and Diabetes (Pidjin English)Written by Michael Ozoemena, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.HypertensionSegment 1: What Is Hypertension?HOST:Let's start with the basics. Blood pressure is the force of blood pushing against the walls of your arteries. Think of it like water running through a garden hose—if the pressure stays too high for too long, that hose starts to wear out.Hypertension, or high blood pressure, means this pressure is consistently elevated. It is measured using two numbers:Systolic: the pressure when the heart beatsDiastolic: the pressure when the heart relaxesNormally reading is around 120/80 mmHg. Hypertension is defined by the American College of Cardiology/American Heart Association (ACC/AHA) as 130/80 mmHg or higher.The American Academy of Family Physicians (AAFP) defines hypertension as persistent elevation of systolic and/or diastolic blood pressure, with the diagnostic threshold for office-based measurement set at 140/90 mm Hg or higher.Segment 2: Why Should We Care?HOST:Hypertension is known as “the silent killer” because most people have no symptoms. Even without symptoms, it steadily increases the risk of:Heart attackStrokeKidney diseaseThink of high blood pressure as a constant stress test on your blood vessels. The longer it goes uncontrolled, the higher the chance of complications.Segment 3: What Causes High Blood Pressure?HOST:Hypertension usually doesn't have a single cause. It often results from a combination of genetic factors, lifestyle, and underlying medical conditions.Modifiable FactorsHigh-salt diet and low potassium intakePhysical inactivityTobacco useExcessive alcohol intakeOverweight or obesityChronic stressPoor sleep or sleep apneaNon-Modifiable FactorsFamily history of hypertensionBlack race (higher prevalence and severity)Age over 65Hypertension may also be secondary to other conditions, such as kidney disease, thyroid disorders, adrenal conditions, or medications like NSAIDs or steroids.Segment 4: How Is It Diagnosed?HOST:Diagnosis requires multiple elevated blood pressure readings taken on different occasions. This includes office readings, home blood pressure monitoring, or ambulatory blood pressure monitoring.If you haven't had your blood pressure checked recently, this is your reminder. It's simple—and it could save your life.Segment 5: Treatment and ManagementHOST:Lifestyle changes are often the first line of treatment:Reduce salt intakeEat more fruits, vegetables, and whole grainsAim for 150 minutes of moderate exercise per weekManage stressMaintain a healthy weightGet enough sleepLimit alcoholQuit smokingIf these steps aren't enough, medications may be necessary. These include:Diuretics, ACE inhibitors, ARBs, Calcium channel blockers, Beta-blockersYour healthcare provider will choose the best medication based on your health profile.Segment 6: What You Can Do TodayHOST:Here are three simple, actionable steps you can take right now:Check your blood pressure—at a clinic, pharmacy, or at home.Pay attention to your salt intake—much of it is hidden in processed foods.Move more—even a 20-minute daily walk can help reduce blood pressure over time.Small steps can lead to big, lasting improvements.SummaryHypertension may be silent but understanding it gives you power. Early action can add healthy years to your life. Take charge of your blood pressure today.Diabetes1. Wetin Diabetes Be and Wetin E Go Do to Person Body?Q: Wetin diabetes mean?A: Diabetes na sickness wey make sugar (glucose) for person blood too high. E happen because the body no fit produce insulin well, or the insulin wey e get no dey work as e suppose.Q: Wetin go happen if diabetes no dey treated well?A: If diabetes no dey treated well, e fit damage the blood vessels, nerves, kidneys, eyes, and even the heart.2. Wetin Cause Diabetes and Why Black People Suffer Pass?Q: Wetin cause diabetes?A: E no be one thing wey cause diabetes. E dey happen because of mix of gene, lifestyle, environment, and society factors.Q: Why Black/African Americans get diabetes more?A: Black people for America get diabetes more because of long-standing inequality, stress, low access to healthcare, and the kind environment wey many of them dey live in. These things dey make Black people more at risk.3. Diabetes Rates for America and Black People?Q: How many people get diabetes for America?A: For America today, over 38 million people get diabetes, and the number dey rise every year.Q: Why Black people dey suffer diabetes more than White people?A: About 12% of Black adults get diabetes, compared to just 7% for White adults. Black people also dey get the sickness earlier and e dey more severe.4. Signs and Symptoms of Diabetes?Q: Wetin be the early signs of diabetes?A: The early signs no too strong, but when e show, e fit include:Too much urine (polyuria)Thirst (polydipsia)Hunger, tiredness, and blurred visionWounds no dey heal fastTingling for hand or legSometimes weight loss5. How Doctor Go Diagnose Diabetes?Q: How doctor fit confirm say person get diabetes?A: Doctor go do some lab tests to confirm:Fasting Plasma Glucose (FPG): 126 mg/dL (7.0 mmol/L) or higherHbA1c: 6.5% or higher2-hour Oral Glucose Tolerance Test (OGTT): 200 mg/dL (11.1 mmol/L) or higher after person drink glucose.Random Blood Glucose: 200 mg/dL (11.1 mmol/L) or higher plus classic symptoms like too much urination, thirst, or weight loss.Q: Wetin happen if HbA1c test no match the person?A: If HbA1c result no match person symptoms, doctor fit repeat test or try other tests like FPG or OGTT.6. Wetin Screening and Early Diagnosis Fit Do?Q: Why screening for diabetes dey important?A: Screening dey important because early detection fit prevent serious complications from diabetes.Q: How often person go do diabetes test?A: Adults wey get overweight or obesity, between 35–70 years, suppose do diabetes screening every three years. But because Black adults get higher risk, doctors dey start screening earlier and more often.7. How Person Fit Manage Diabetes?Q: Wetin be the best way to manage diabetes?A: The two main ways to manage diabetes be:Lifestyle changes: Eat better food (vegetables, fruits, whole grain, beans, fish, chicken) and exercise regularly.Medicine: If person sugar still high, doctor fit give drugs like metformin, SGLT-2 inhibitors, or GLP-1 receptor agonists.Q: Wetin be SGLT-2 inhibitors and GLP-1 drugs?A: SGLT-2 inhibitors dey help with kidney and heart problems, while GLP-1 drugs dey help with weight loss and prevent stroke.Q: Wetin be first-line treatment for diabetes?A: First-line treatment for diabetes be metformin, unless person no fit tolerate am.Q: How much exercise a person suppose do?A: Person suppose do at least 150 minutes of moderate exercise per week. This fit include things like brisk walking, swimming, or cycling. E also good to add muscle-strength training two or three times weekly to help control sugar.Q: When insulin therapy go be needed?A: Insulin therapy go be needed if person A1c is higher than 10%, or if person dey hospitalized and their glucose dey above the 140-180 range. This go help bring the blood sugar down quickly.8. Wetin Be the Complications of Diabetes?Q: Wetin fit happen if diabetes no dey well-managed?A: Complications fit include kidney disease, blindness, nerve damage, leg ulcers, heart attack, stroke, and emotional issues like depression.Q: Why Black adults get more complications?A: Black people get higher risk of these complications because of inequality, stress, and poor access to healthcare.9. Wetin Dey Affect Access to Diabetes Treatment?Q: Wetin make Black people struggle to get treatment for diabetes?A: Many Black people no dey get new effective treatments like GLP-1 and SGLT-2 inhibitors because of price, insurance issues, and lack of access. COVID-19 also worsen things.Q: Wetin government and doctors fit do?A: Policymakers dey work on improving access to drugs, better community programs, and screening for social issues wey fit affect diabetes care.10. ConclusionQ: Wetin be the solution to reduce diabetes impact?A: The solution go need medical treatment, early screening, lifestyle support, and policy changes. With proper treatment and community support, e possible to reduce the impact of diabetes, especially for Black communities.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________References: Whelton PK, Carey RM. Overview of hypertension in adults. UpToDate. 2024.Carey RM, Moran AE. Evaluation of hypertension. UpToDate. 2024.Mann SJ, Forman JP. Lifestyle modification in the management of hypertension. UpToDate. 2024.Giles TD, Weber MA. Initial pharmacologic therapy of hypertension. UpToDate. 2024.American Heart Association. Understanding Blood Pressure Readings. Accessed 2025.American Heart Association. AHA Dietary and Lifestyle Recommendations. Accessed 2025.Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/.

In this episode, hosts Diana Isaacs, PharmD, and Natalie Bellini, DNP, breakdown recent trial news from the 2 most popular incretin therapies: semaglutide and tirzepatide. First, hosts breakdown the November 24, 2025 announcement from Novo Nordisk disclosing their evoke and evoke+ trials of oral semaglutide in early symptomatic Alzheimer Disease failed to slow disease progression. Next, hosts break down the TIRTLE study, which examined use of tirzepatide in patients with type 1 diabetes. Semaglutide Misses Mark in Alzheimer Disease Novo Nordisk announced top-line results from the evoke and evoke+ phase 3 trials showing oral semaglutide 14 mg did not slow disease progression over 2 years in adults with early symptomatic Alzheimerdisease, with no significant difference in CDR-SB change versus placebo. Despite improvements in Alzheimer-related biomarkers across both studies, neither trial demonstrated a slowing of clinical decline. evoke was a global, randomized, double-blind, placebo-controlled trial enrolling 1,855 participants aged 55–85 with amyloid-positive CDR 0.5 MCI or CDR 1.0 mild dementia, treated 1:1 with semaglutide or placebo for 104 weeks plus a planned 52-week extension. evoke+ mirrored this design, randomizing 1,953 participants with the same eligibility criteria to daily semaglutide 14 mg or placebo for a total planned duration of 156 weeks. Findings from the trials will be presented at the 2025 Clinical Trials in Alzheimer's Disease (CTAD) conference on December 3, 2025. The lack of efficacy led to discontinuation of the planned 1-year extension period across both trials, though safety and tolerability remained consistent with prior semaglutide experience in diabetes and obesity. TIRTLE: Tirzepatide Shows Benefit in Type 1 Diabetes In a 12-week, double-blind, placebo-controlled phase 2 trial of 24 adults with type 1 diabetes and BMI >30 kg/m², tirzepatide produced a 10.3-kg mean weight loss versus 0.7 kg on placebo, an −8.7-kg treatment difference (P < 0.0001) corresponding to 8.8% total body weight reduction. All tirzepatide-treated participants achieved ≥5% weight loss, and 45% achieved ≥10%, compared with 9% and 0% in the placebo group. Eligibility criteria required patients to be 18 years of age or older, with confirmed type 1 diabetes, obesity (BMI >30), and stable insulin therapy. Tirzepatide also improved glycemic control, reducing HbA1c by 0.4%, and decreased total daily insulin dose by 35% relative to placebo (−24.2 vs −0.3 units/day). Safety data suggested no significant adverse events occurred, with 22 of the 24 participants completing the study. Relevant disclosures for Isaacs include Eli Lilly and Company, Novo Nordisk, Sanofi, Abbott Diabetes Care, Dexcom, Medtronic, and others. Relevant disclosures for Bellini include Abbott Diabetes Care, MannKind, Provention Bio, and others. References: Novo Nordisk. Novo Nordisk A/S: Evoke phase 3 trials did not demonstrate a statistically significant reduction in Alzheimer's disease progression. Novo Nordisk. November 24, 2025. Accessed November 24, 2025. https://www.novonordisk.com/content/nncorp/global/en/news-and-media/news-and-ir-materials/news-details.html?id=916462. Snaith JR, Frampton R, Samocha-Bonet D, Greenfield JR. Tirzepatide in Adults With Type 1 Diabetes: A Phase 2 Randomized Placebo-Controlled Clinical Trial. Diabetes Care. Published online November 20, 2025. doi:10.2337/dc25-2379

This week on Fat Science, Dr. Emily Cooper, Mark Wright, and Andrea Taylor field your most urgent metabolic health questions—exploring care advocacy, novel drug use, lab results, and how to filter fact from fiction in the TikTok age. Dr. Cooper offers clinical clarity, real-world perspective, and actionable hope—with an emphasis on what truly matters for your long-term health and energy.Hear from listeners experiencing real breakthroughs (and challenges) with GLP-1s, get tips for navigating confusing cholesterol results, and learn why self-advocacy and good science matter more than credentials or hype. This is not a quick-fix episode; it's real metabolic medicine, mythbusting, and grounded encouragement for your health journey.Key Questions AnsweredWhat labs and scores best assess your true metabolic risk—and how do you make sense of fasting glucose, glucose-insulin ratio (GIR), and FIB-4?How can you find a medical provider who'll actually give you the time and attention metabolic care requires?Why do GLP-1s benefit more than weight loss alone? Listeners report help with sleep apnea, inflammation, and food noise—what does the science say?How should you reintroduce carbs after restriction, and what's the safest way to monitor (beyond A1C)?What's up with rising cholesterol on Zepbound, and when do you worry?Does serotonin syndrome relate to GLP-1s? (Short answer: No—Dr. Cooper explains why.)What are the dangers of “GLP-1 microdosing” as pushed by social media, and what happens when influencers overstep good science?Key TakeawaysCare that cares: The best doctor isn't always the most credentialed—find someone, MD, NP, or PA, who takes your questions seriously and goes deeper than the surface. Labs that matter: Fasting glucose, insulin, GIR, HbA1c, plus advanced lipid testing (CardioIQ, NMR) are critical for uncovering hidden risk—not just chasing numbers. GLP-1s act broadly: Listeners see gains in sleep, inflammation, and appetite regulation. These benefits are real, not just anecdotal, and Dr. Cooper shares the clinical rationale. Smart fueling, even on GLP-1s: If you lack hunger cues, “mechanical eating” prevents under-fueling and cellular stress—especially important for maintaining muscle and metabolism. Rethinking “microdosing”: TikTok trends are not medical advice—microdosing with black-market GLP-1s is unproven, poorly regulated, and potentially unsafe. Rely on trusted, legal medication sources only. Dr. Cooper's Actionable TipsRequest a full panel for metabolic health: ask your provider about fasting insulin, GIR, HbA1c, lipids, and FIB-4—even if you haven't been flagged as “at risk”. For those on GLP-1s: Don't skip meals; create a schedule with protein and fiber to avoid muscle loss and ensure micronutrient intake. Experiencing cholesterol shifts on medication? Ask for a breakdown (HDL, LDL, particle size) and consider advanced panels (CardioIQ, NMR) to better understand your risk. If reintroducing carbs after restriction, pair them with protein or fat and test glucose/insulin at intervals post-meal to personalize your plan. Avoid unregulated “microdosing” and buy only from reputable, FDA-approved outlets—protect your long-term health over quick fixes. Notable Quote“The most important thing is somebody who cares, not necessarily their degrees.”— Dr. Emily CooperLinks & ResourcesPodcast Home: Fat Science Podcast WebsiteSubmit a Show Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.comDr. Emily Cooper on LinkedInMark Wright on LinkedInAndrea Taylor on InstagramAdvanced cholesterol testing: CardioIQ at Quest, NMR at LabCorpFat Science is your source for breaking diet myths and advancing the science of true metabolic health. No diets, no agendas—just science that makes you feel better. The show is informational only and does not constitute medical advice. 

En este vídeo te explico el verdadero papel del páncreas en tu rendimiento, tu energía y tu composición corporal. No es un vídeo más sobre “azúcar e insulina”. Es un mapa completo para entender qué pasa realmente dentro de tu cuerpo cada vez que comes, entrenas o descansas. Qué aprenderás hoy: Insulina y glucagón: el interruptor metabólico que decide si almacenas o movilizas energía. Por qué puedes tener una glucosa “normal”… pero años de hiperinsulinemia silenciosa. Cómo interpretar glucosa, insulina, HOMA-IR, HbA1c y fructosamina como un profesional. Diferencia REAL entre diabetes tipo 1 y tipo 2 explicada con la metáfora de la llave y la cerradura. Qué pasa en atletas cuando hay buen rendimiento pero mala sensibilidad a la insulina. Las claves prácticas para mejorar tu metabolismo desde hoy mismo. Si eres atleta, entrenador, o persona activa, este vídeo es clave para entender por qué algunas personas mejoran… y otras se estancan a pesar de entrenar igual. Más contenido como este en mi libro de hormonas y rendimiento. Si quieres que analice tu analítica o tu sensibilidad a la insulina, escríbeme.

In this week's episode of the Full of Beans podcast, Han is joined by Dr Tomos Williams. Tom has worked in the CWP Eating Disorder Service since May 2022. He works across community and specialist inpatient settings. He is the Psychiatric lead in the regional Type 1 Diabetes and Disordered Eating Clinic, the local MEED lead, and also works with patients with complex presentations, acting as a link person for local acute trusts. He is a member of the Royal College of Psychiatry Eating Disorder Faculty Executive Committee.This week, we discuss:What T1DE is, and why “diabulimia” is an outdated termThe life-threatening risks of insulin omissionHow eating disorders and diabetes treatment often conflictWhy T1DE clinics are essential, but underfundedThe role of eating disorder and diabetes professionalsWhat joined-up, trauma-informed care looks likeThe outcomes and success of T1DE pilotsThe urgent need for political support to save these servicesTimestamps:01:30 – What is Type 1 Diabetes and Disordered Eating (T1DE)04:00 – Medical risks associated with insulin omission08:50 – Building the T1DE clinic & lack of national funding13:10 – The power of a multi-disciplinary team18:40 – Early signs of T1DE and what clinicians should look for22:10 – Impact of trauma & perfectionism in diabetes25:00 – Outcomes & HbA1c improvements29:00 – Barriers to insulin pump access33:20 – Can you recover from EDs while managing diabetes?Resources & Links:The Compassion Project (Wessex & London T1DE Pilot)Parliamentary Inquiry into T1DE (2023)Diabetes UK on T1DEWant to help save T1DE services?Write to your local MP and demand continued funding. Mention the NHS England pilot outcomes and the need for integrated care for patients with type 1 diabetes and eating disorders.Connect with Us:Subscribe to the Full of Beans Podcast hereFollow Full of Beans on Instagram hereCheck out our website here⚠️ Trigger Warning: This episode discusses lived experiences of eating disorders, restrictive behaviours, and mentions of specific foods. Please take care when listening.If you enjoyed this episode, don't forget to subscribe, rate, and share the podcast to help us spread awareness.Sending positive beans your way, Han

Why You Should Listen:  In this episode, you will learn about the vast role that nitric oxide plays in supporting health and strategies to increase nitric oxide. About My Guest: My guest for this episode is Beth Shirley.  Beth Shirley, RPh, CCN, developed an expertise as a compounding pharmacist and board-certified clinical nutritionist during a career spanning over 40 years.  She has been a pioneer at the cutting edge of the evolution of what has now come to be known as "Integrative Pharmacy", the junction between traditional pharmacy and the clinical use of nutritional supplementation.  Since 2009, Beth has spent time working with some of the leading thought leaders in the world of nitric oxide research and through this has developed an in-depth knowledge of the topic and its potential applications in patient care.  In addition, she has worked closely with the scientific community and cutting-edge companies working on innovative nutritional ingredients and approaches for their use in a variety of life's challenges. In fact, Beth has formulated a product that was awarded the first patent on a supplement to "increase sexual desire and pleasure".  She currently is the Director of Education and Research for Approved Medical Solutions, the distributor of her oxalate-free nitrate product and her Libby line of women's wellness products. Key Takeaways: What is nitric oxide (NO)? What functions does NO play in the body? What causes NO to be low? How can NO be supported with diet? Does NO level play a role in COVID? What is the connection between NO and methylation? Does NO have a role in the management of infections? What are the two pathways through which NO is created in the body? What is the connection between glyphosate and NO? How can any potential downsides of increasing NO be minimized? What is the role of NO in systemic inflammation? How does NO impact glucose, insulin, HbA1c, metabolic syndrome, and diabetes? What role does NO play in cardiovascular disease? Does NO impact MCAS and histamine? Can NO have a beneficial effect on intestinal hyperpermeability or on the microbiome? Does NO impact detoxification? Can methylene blue be used with NO? Connect With My Guest:  LinkedIn Related Resources: To view details about the products discussed in this episode, visit Approved Medical Solutions. Nitric Oxide (N-O) Libby Line To purchase products discussed in this episode, you must first create an account.  Use Referral Code BETTERHEALTH to create your account. Once registered, you will receive 10% off on all orders and an additional 5% off on your first order using discount code BETTERHEALTH. Interview Date: October 30, 2025 Transcript: To review a transcript of this show, visit https://BetterHealthGuy.com/Episode224. Support the Show: To support the show and Buy Me a Coffee, visit https://betterhealthguy.link/BuyMeACoffee. Additional Information: To learn more, visit https://BetterHealthGuy.com. Follow Me on Social Media: Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy Disclosure: BetterHealthGuy.com is an affiliate of Approved Medical Solutions. Disclaimer:  The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority. 

AI isn't just transforming how we work; it's quietly revolutionizing how we eat, move, sleep, and age. From smart devices that detect stress before you feel it to algorithms that predict illness years in advance, technology is giving us the tools to understand our bodies like never before. But beneath all the hype, what really matters is how we use that data to live better, not just longer.In this episode of The Wellness Algorithm, we are joined by Dr. Marcus Ranney, longevity physician. Together, we dive into the new frontier where biology meets technology, exploring how AI is reshaping fitness, nutrition, and recovery to make wellness deeply personal and preventive. We talk about what true biohacking means, why small daily choices matter more than expensive gadgets, and how science is helping us extend not just our lifespan but our healthspan. Dr. Ranney explains how AI is becoming our health ally, decoding everything from sleep quality to metabolic patterns, and how even the simplest changes like improving sleep or reducing stress can biohack your body for better energy, focus, and longevity.To help you start your own data-led wellness journey, here are some core tests and metrics he recommends for personalized health insights:Metabolic Health Tests: Fasting blood sugar, fasting insulin, HbA1c, and a full lipid profile (HDL, LDL, triglycerides).Micronutrient Panels: Vitamin D3, Vitamin B12, Iron, Magnesium, Zinc, Selenium, and Albumin.Inflammation Markers: CRP and Cortisol to assess chronic stress and systemic inflammation.Gut Health Tests: Microbiome and saliva tests to measure bacterial diversity and gut balance.Wearable Metrics: Heart rate variability, sleep tracking, and continuous glucose monitoring for real-time feedback.This episode isn't about chasing perfection or becoming robotic; it's about learning to use technology to understand yourself better. You'll walk away with practical tools, a new perspective on wellness, and a glimpse of how AI can help you stay healthier, longer while keeping your humanity at the center of it all.For a transcript of this show, go to https://wellnesscurated.life/biohacking-with-ai-the-future-of-fitness-nutrition-longevity-2/Leave a review

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In this episode of Wholistic Living, we're unpacking the truth about HbA1c, insulin resistance, and metabolic health, beyond just what you eat. You'll learn exactly what HbA1c measures, how insulin works on a cellular level to move glucose into your cells for ATP energy, and what happens when that process breaks down. We'll explore how stress, poor sleep, inflammation, toxins, and hormone imbalances all drive insulin resistance, even if your diet looks “clean.” I also share the most effective supplements for improving insulin sensitivity and supporting healthy HbA1c levels, including magnesium, inositol, berberine, fish oil, NAC, glycine, alpha-lipoic acid, and plant sterols and explain how each one helps your cells use glucose efficiently instead of storing it as fat. If you've ever struggled with blood sugar swings, fatigue after meals, high cholesterol, or stubborn weight gain, this episode connects the dots between glucose metabolism, hormones, and holistic healing.Join the 60 Day Gut Reset & Start When You're ready with $200 OFF! https://checkout.teachable.com/secure/1716725/checkout/order_4mzzdrn3?coupon_code=SECRETOFFEREquip Foods Grass-fed beef protein - Code: MARLAWant to work with me? email me to health@holisticspring.com

Our guest, Hunter Ziesing shares his work with AI in assisting individuals in their quest for health and longevity.   Hunter spent the bulk of his career in investment banking focusing on the Healthcare, Consumer, and Technology areas. He was the founder of Charity of Choice, a non-profit focused on cancer research and health prevention. Early Overall Outcomes Biomarker Improvements A majority of patients showed significant movement in at least one critical biomarker (ApoB, VAT, bone density, VO2Max, HbA1c). ~80% improved at least one key biomarker. Common improvements included reductions in ApoB, decreases in visceral fat (VAT), and gains in lean mass/bone density. Major Findings from Diagnostics ~65% of patients had at least one significant finding from testing (e.g., early CAD on Cleerly, sleep apnea, insulin resistance, GI imbalances). These findings directly shaped interventions and escalations in care. Symptom Reversals ~30% experienced meaningful reversal of previously severe symptoms (e.g., hypertension control, prediabetes reversal, improved sleep apnea, reduction in chronic GI symptoms). Resources: ai.longevityhealth.me Our Sponsor: Haven Medical maker of the Cox 8 Table  

If you want to improve your energy and long-term health, start by understanding how your body uses glucose.In this episode of A Whole New Level, Dr. Benjamin Bikman, scientist and author of Why We Get Sick, joins Mike Haney to unpack the science of glucose metabolism and insulin resistance—and why blood sugar isn't the whole story.Dr. Bikman explains how insulin regulates energy balance, why HbA1c is only part of the picture, and how chronic high insulin can silently drive weight gain, fatigue, and metabolic disease. He also shares practical ways to lower insulin naturally through diet, exercise, and daily habits.They discuss:Why insulin, not glucose, is the root of metabolic dysfunctionWhat HbA1c and fasting glucose really tell youThe early signs of insulin resistance most people missHow muscle tissue protects against high glucose and insulinWhy low-carb and intermittent fasting aren't one-size-fits-allPractical nutrition and movement strategies for better metabolic flexibilitySign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl

n the News.. COVID-19 & T1D, Ozempic Pill Progress, Faster Insulin, “Beyond Misconceptions,” and More It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: A new study looks at the link between COVID-19 and very young children, Lilly moves ahead with their Ozempic oral pill, ultra-rapid insulin clears another hurdle, Beyond Type 1 launches a new campaign and more! Find out more about Moms' Night Out  Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom   Check out VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Reach out with questions or comments: info@diabetes-connections.com Episode transcription with links: Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. XX https://www.scientificamerican.com/article/advances-in-type-1-diabetes-science-and-tech/ This article is part of “Innovations In: Type 1 Diabetes,” an editorially independent special report that was produced with financial support from Vertex. XX More evidence linking COVID 19 to type 1 diabetes.. but still exactly why is a mystery. During the COVID-19 pandemic, there was an unexpected increase in the number of cases of type 1 diabetes in Sweden, particularly among children under 5 and young adult men. The infection accelerated the onset of diabetes among children between the ages of 5 and 9. The researchers looked at data from a 17-year period on the incidence of type 1 diabetes among all people under the age of 30 in Sweden. In addition, they compared the risk of developing diabetes among 720,000 individuals with positive COVID-19 tests against a control group of 3.5 million people. The findings are published in the journal Diabetologia. The number of diabetes cases increased by 12% in 2021 and 9% in 2022 compared with previous years. In 2023, the number of cases was back to a normal level. Despite this, the researchers cannot distinguish a clear connection between COVID-19 infection and diabetes, except for children between 5 and 9 years old. They had an increased risk of type 1 diabetes about one month after a COVID-19 infection even though their total risk did not increase. "However, it's clear that the COVID-19 vaccine can be ruled out as a cause of the increase in diabetes cases. The recommendation for the age group where we saw the strongest increase was not to get vaccinated. In addition, other studies on adults have shown that vaccination reduces the risk of developing type 1 diabetes after a COVID infection." https://medicalxpress.com/news/2025-10-diabetes-young-people-pandemic.html XX A new gene therapy approach aimed at protecting people with type 1 diabetes from developing diabetic kidney disease—a serious and common complication of the condition, has shown promising results in a University of Bristol study. Findings from this new study, published in Molecular Therapy, demonstrated a 64% reduction in a damage indicator for kidney disease, paving the way for a potential new treatment. The study, explored the potential of delivering a protein called VEGF-C directly into kidney cells. Previous studies have shown VEGFC could protect against kidney disease as it helps keep blood vessels in the kidney filter healthy, repairing early signs of diabetes-related kidney damage. https://medicalxpress.com/news/2025-10-gene-therapy-kidney-disease-diabetes.html XX The FDA has agreed to consider Afrezza inhaled insulin for children and teens. The company said in August that it submitted a supplemental Biologics License Application (sBLA) for Afrezza in the pediatric population and it's been assigned a decision deadline date of the end of May, 2026. Afrezza first recieved FDA approval for adults (age 18 and up) in June 2014 https://www.drugdeliverybusiness.com/fda-accepts-application-mannkind-inhaled-insulin-kids/ Update on inhaled insulin for kids.. in the open-label, randomized, phase 3 INHALE-1 clinical trial Afrezza demonstrated safe and effective replacement for rapid-acting meal insulin in children with type 1 diabetes (T1D and demonstrates comparable glycemic control to injected rapid-acting insulin. The INHALE-1 clinical trial assessed the safety and efficacy of Afrezza among children and adolescents with T1D, including a total of 230 patients aged 4 to 17 years. Researchers used basal injected insulin and randomly assigned inhaled insulin or rapid-acting analogue for meals, evaluating the change in hemoglobin A1c levels at 26 weeks. After completing 26 weeks of randomly assigned treatment with either Afrezza or rapid-acting insulin injections combined with basal insulin, participants continued receiving the inhaled insulin until week 52 for an extension phase to evaluate the safety and effectiveness of Afrezza with continued use.1,2 https://www.pharmacytimes.com/view/inhaled-insulin-demonstrates-comparable-safety-lung-function-and-efficacy-to-injectable-insulin-in-type-1-diabetes XX Eli Lilly released the results of two new Phase 3 trials of an experimental GLP-1 pill that the company says could become a “foundational treatment” for type 2 diabetes. The Indianapolis-based drugmaker plans to submit global regulatory applications for orforglipron in the treatment of type 2 diabetes next year. The company said it will seek approval of the drug as an obesity medication by the end of 2025. Lilly is trying to build on the success of its Mounjaro/Zepbound franchise by offering patients a pill instead of an injection. But the company is trailing behind rival Novo Nordisk in developing an oral alternative, and data released so far has raised some skepticism among investors. A study released in August showed that orforglipron could help patients lose an average of about 12% of their body weight. Wall Street had been expecting more; Lilly's injectable drug Zepbound produced weight loss of as much as 21%, and Novo Nordisk has achieved 15% weight loss percentages for both oral and injectable versions of its Wegovy medication.   https://www.fiercebiotech.com/biotech/eli-lillys-orforglipron-bests-farxiga-padding-oral-glp-1-case-pair-phase-3-diabetes-wins   XX XX UF Health Cancer Center researchers have found a surprising culprit behind common health problems such as obesity, diabetes and fatty liver disease: silent genetic glitches in the blood system that occur naturally as people age. The findings, published in the Journal of Clinical Investigation, mean that in the future, simple blood tests could be developed to identify people most at risk early on, helping prevent chronic illnesses and cancer through strategies like diet or lifestyle changes. As people age, stem cells in the bone marrow that produce blood cells gradually accumulate mutations in their DNA. Most mutations don't cause any issues, but sometimes blood stem cells with a mutation can start crowding out their peers. Called clonal hematopoiesis, this condition affects about 10% of older people and is associated with an increased risk of blood cancers like leukemia. It's also linked to a higher risk of obesity and diabetes. But the prevailing thinking was that obesity and related conditions promoted blood cell changes, not the other way around. The new study reverses that. The implications could be far-reaching, particularly as obesity has now overtaken smoking as the most significant and preventable risk factor for cancer. The team is studying how the mutations drive disease. Next, they plan to test how drugs like those commonly used to treat diabetes and new popular weight loss drugs might help reverse or prevent diseases caused by blood cell changes. https://medicalxpress.com/news/2025-10-hidden-blood-mutations-obesity-diabetes.html XX A new ultra rapid insulin continues to move forward. A phase 3 clinical trial of BioChaperone Lispro (liss-pro) conducted in China found it safe and effective compared with Humalog along with a significant reduction of the rise of blood glucose after a test meal.     These results complete and confirm the positive outcomes previously obtained with THDB0206 injection in people with Type 2 Diabetes It combines Adocia's proprietary BioChaperone® technology with insulin lispro, the active ingredient in the standard of care, Humalog® (Eli Lilly).   This innovative formulation acts significantly faster https://pharmatimes.com/news/ultra-rapid-insulin-shows-promise-in-phase-3-trial-for-type-1-diabetes/   Poor blood sugar control in adolescent patients with type 1 diabetes (T1D) may be associated with a higher risk of neuropathy in adulthood, according to recent research from the University of Michigan.1 The study included children diagnosed with T1D between 1990-1992 who were recruited into the Cognition and Longitudinal Assessment of Risk Factors over 30 Years cohort study in Australia. Investigators collected HbA1c from medical records, and microvascular complications were assessed through self-reports, clinical screenings, retinal photographs, and urinary albumin-creatinine testing.3   A total of 30 children were recruited from the original cohort with a mean diagnosis age of 2.9 years. After an average of 29.7 years (standard deviation [SD]: 3.9 years), 33% of participants (n = 13) developed neuropathy, 63% (n = 19) developed diabetes-related eye disease, and 10% (n = 3) developed neuropathy.3 Mean HbA1c estimates during adolescence (9% [74.9 mmol/mol]; 95% CI, 8.6-9.3 [70.5-78.1]) were substantially higher than childhood (8.2% [66.1 mmol/mol]; 95% CI, 7.8-8.5 [61.7-69.4]; P

See all the Healthcasts at https://www.biobalancehealth.com/healthcast-blog As the founder and Medical Director of BioBalance® Health, an anti-aging longevity practice for 23 years, I have long sought a blood test that serves as a reliable indicator of aging and disease risk. Identifying those at highest risk allows me to better motivate patients to follow my treatment plan and pursue a longer, healthier life. For people who test negative, I would reassure them they are doing well and encourage them to maintain healthy habits. Over time, I assessed common medical tests that many doctors use to steer patients toward certain treatments that do not reduce pain and may shorten life. I examined the actual risk of death and illness through clinical evaluations and credible, though less publicized, research studies. Here is what I found: Elevated blood lipids are not reliably predictive of vascular plaque. In my experience, both high and low cholesterol patients show similar rates of plaque in Cardiac Calcium Scans. Despite this, primary care physicians often prescribe statins, which may be unnecessary for many. Statins were not initially tested on women, who tend to experience more severe side effects such as cognitive impairment, muscle breakdown, and fatigue, likely because these drugs impact mitochondrial function—the cell's energy source. BMI has long been used to assess whether someone is at a healthy or risky weight, but it is often inaccurate. It overlooks individuals with low muscle and high fat, while labeling muscular people as overweight. As a result, BMI is being replaced by body composition measurements.   Recently, body composition analysis using InBody has become more common than BMI for evaluating patient health, frailty, and muscle mass. Measurements of visceral fat and body composition are considered indicators of current health status. BMI is a straightforward calculation that only uses height and weight, whereas body composition includes assessments of visceral fat and percent body fat. Only one weight- and height-based test directly relates to health status. High muscle mass indicates health, while excess visceral fat signals risk, and normal body fat percentage reflects current—but not future—health. Since body composition can shift over time, it is a useful measure of present health but does not reliably predict longevity and is just one aspect of overall health. Several blood tests can indicate current health, such as fasting blood sugar, HbA1c, IGF-1, and fasting insulin. For assessing future health risks and existing damage, HS-CRP (high-sensitivity C-reactive protein) is crucial, as it measures inflammation—a major factor in unhealthy aging and reduced longevity, especially when levels exceed 3.0. An article in Life Extension (July 2025) refers to persistently high CRP as “inflammaging.”   The Truth About Aging and Inflammation? Temporary spikes in HS-CRP from infections or surgeries usually do not cause lasting issues unless inflammation persists. Chronically high HS-CRP levels (>3) are linked to various age-related diseases, such as obesity, arteriosclerosis, autoimmune disorders, poor dental hygiene, and other conditions that reduce health and lifespan. We now can measure “inflammaging” with HS-CRP blood test.  This test indicates increased risk of heart disease, cancer, stroke, dementia, autoimmune disease, and other degenerative diseases.” A review of studies with more than 400,000 participants revealed that people with a High HS-CRP had 75% increased risk of all-cause mortality compared to people with a low HS-CRP. These studies found that HS-CRP may be a more reliable predictor of heart attack and stroke, than LDL cholesterol! HS-CRP may predict age-related diseases because chronic inflammation leads to issues such as arterial plaque and Alzheimer's. Although white blood cells fight infection, their persistent activity can damage healthy tissue and accelerate age-related conditions. The changes that you can make to decrease inflammation, Inflammaging, include: Fat loss to ideal weight Low inflammatory mediterranean diet Omega 3 oil supplements or in food Daily exercise Probiotics Quercetin supplement Treat joints that are damaged (inflammation is increased with injured joints) At least 3 cups of coffee per day Less than 4 oz of alcohol a day No sugar in the diet ***Replacing hormones to the levels of a young man or women with non-oral hormones, pellet testosterone for men and both testosterone and estradiol for women.   BioBalance® Health assesses new information through medical studies and bases treatments on knowledge of human physiology and the aging processes. No single test can determine if you are aging well, but HS-CRP is a better indicator than cholesterol or BMI. At BioBalance®, we've tested HS-CRP for 20 years and developed treatments to address inflammaging. Citation: Life Extension –July 2025

Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours This week on the podcast Mikki speaks to Dr CAtherine Crofts in part 2 of their discussion on health about challenging the status quo in nutrition science. Together they take a critical look at the flaws in current dietary guidelines, particularly the persistence of high-carbohydrate, low-fat recommendations despite mounting evidence for alternative approaches.The conversation dives into how our bodies handle minimally processed versus highly processed carbohydrates, the individuality of carbohydrate tolerance, and why excessive processed carbs play such a central role in driving insulin resistance and chronic disease. Drawing on evolutionary and anthropological insights, the discussion considers what our history of hunting, brain expansion, and plant consumption suggests about human adaptation to diet. This leads into the striking health shifts seen in indigenous populations exposed to modern foods, and whether refined carbs and oils are the primary culprits or part of a wider cultural disruption.Dr Catherine Crofts is a pharmacist, researcher, and lecturer based in New Zealand with a special interest in the early detection and prevention of metabolic disease. She completed her PhD at Auckland University of Technology, where she analysed the extensive insulin assay data collected by Dr Joseph Kraft, shedding light on how abnormal insulin responses can precede changes in blood glucose by many years.Catherine's work focuses on hyperinsulinemia as a key driver of chronic disease, highlighting the limitations of relying solely on glucose-based measures such as HbA1c or fasting glucose. She has presented internationally on the clinical importance of Kraft's insulin patterns, advocating for earlier and more nuanced testing to improve long-term health outcomes.With a background that combines pharmacy practice, clinical research, and teaching, Catherine brings a rare blend of practical experience and scientific insight to the conversation around metabolic health and diabetes prevention.linkedin.com/in/catherine-crofts-4a25537b?originalSubdomain=nzhttps://academics.aut.ac.nz/catherine.crofts Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden

Dr. Leonard Egede, Dr. Rebekah Walker, and Dr. Obinna Ekwunife from the Department of Medicine at the University of Buffalo, NY, describe their #research paper #published in Volume 17, Issue 8 of Aging-US, entitled “Longitudinal relationship between social and CVD risk factors in older adults with prediabetes: the HRS 2006-2016.” #interview #authorinterview #aging #prediabetes #cardiovascular #health #openaccess #openscience #peerreviewed #journal #publication #publishing #meded DOI - https://doi.org/10.18632/aging.206308 Corresponding author - Leonard E. Egede - legede@buffalo.edu Video interview - https://www.youtube.com/watch?v=1MSTk3GQAGA Video transcript - https://aging-us.net/2025/10/08/behind-the-study-social-and-cardiovascular-risk-factors-in-older-adults-with-prediabetes/ Abstract Background: This study examines how multiple social risk factors influence cardiovascular disease (CVD) risk control over time in older adults with prediabetes using a nationally representative cohort. Methods: Data from the Health and Retirement Study (HRS) included 5,086 U.S. adults aged 50+ with prediabetes. Five social risk domains (economic stability, environment, education, healthcare, and social context) were examined as independent variables, while CVD risk factors included glycemic control (HbA1c), systolic blood pressure (SBP), and cholesterol ratio (total cholesterol/high-density lipoprotein). Mixed-effects models assessed relationships between social risk factors and CVD outcomes, adjusting for age, gender, race, and marital status. Results: The sample had an average age of 68.6 years, with 60.2% female, and 70.97% identifying as non-Hispanic Black. Average HbA1c was 5.7, SBP 129.4, and cholesterol ratio 3.85. Limited education was consistently associated with increased CVD risk—HbA1c (β = 0.03, 95% CI: 0.01–0.06, p < 0.001), SBP (β = 4.34, 95% CI: 2.96–5.71, p < 0.001), and cholesterol ratio (β = 0.08, 95% CI: 0.01–0.16, p < 0.05) —in the fully adjusted model. Medication cost-related non-adherence was significantly associated with higher HbA1c levels (β = 0.03, 95% CI: 0.002–0.06, p < 0.05). Difficulty paying bills and lack of health insurance were both significantly associated with higher cholesterol levels (β = 0.03, 95% CI: 0.002–0.06, p < 0.05) and (β = 0.22, 95% CI: 0.15–0.30, p < 0.001), respectively. Conclusions: Social risk factors, particularly limited education, significantly impact CVD risk in older adults with prediabetes. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206308 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, prediabetes, social determinants of health, health equity, cardiovascular health, population health To learn more about the journal, visit https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Diabetes management during pregnancy, nutrition, and breastfeeding. Maintaining proper blood sugar control is essential for women with pre-existing Type 1 or Type 2 diabetes, as well as those with gestational diabetes. Pre-conception counseling is important to ensure that HbA1c, fasting, and post-meal blood glucose levels are within safe limits, along with monitoring blood pressure, cholesterol, and weight to reduce pregnancy complications. During pregnancy and delivery, insulin doses are carefully adjusted, and breastfeeding initiation is emphasized, as insulin is safe during lactation and helps maintain blood sugar stability. Postpartum, women with gestational diabetes should continue healthy habits to minimize the risk of future diabetes and metabolic disorders. Early detection of mildest form of hyperglycemia and its intensive treatment is mandatory in pregnancy. To protect the growing fetus from diabetes, obesity and other non-communicable diseases in their adult life. This is termed as primordial prevention. This concept also plays an important role in reducing transgenerational diabetes risk. Dietitian Dr. Kavita Gupta provided practical guidance on nutrition for pregnant and lactating women. She highlighted the benefits of high-fiber foods, high protein diet with nuts, seeds, and millets, and encouraged using multi-grain flour for balanced meals. She explained portion control, protein requirements across trimesters, and during lactation, and emphasized incorporating nutrient-dense foods while avoiding excess fats and sugars. Dr. Kavita also discussed the importance of washing vegetables thoroughly, lightly steaming sprouts, and using vitamin-rich foods to enhance absorption. She stressed that supplements are only necessary if a deficiency is confirmed, otherwise balanced diet alone is sufficient. Her advice focused on improving milk quality, maternal and infant health, and sustaining energy levels for mothers during pregnancy and breastfeeding. Expert- Dr Sunil Gupta & Dr Kavita Gupta Anchor- Mrs.Vaidehi Chaware Podcast: 25/07/2025 Recorded at: Akashwani Nagpur Episode: 81

It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: Sanofi lowers prices, oral pill for T1D prevention studied, updates from Medtronic, Tandem, and Sequel Med Tech, falsely lower A1Cs (and why that happens), Biolinq gets FDA okay for micro-needle CGM and more! Find out more about Moms' Night Out  Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom   Check out VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Reach out with questions or comments: info@diabetes-connections.com Episode transcription with links:   Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. XX French drugmaker Sanofi says it would offer a month's supply of any of its insulin products for $35 to all patients in the U.S. with a valid prescription, regardless of insurance status. The program, originally meant for uninsured diabetes patients, would now include those with commercial insurance or Medicare, the drugmaker said. Patients will be able to purchase any combination, type, and quantity of Sanofi insulins with a valid prescription for the fixed monthly price of $35, starting January 1. Lilly and Novo also have similar programs through which they offer insulin products for $35 a month for U.S. patients regardless of whether the patients have insurance. There is no law at work here – the only legislation that has changed the price of insulin came with the Inflation Reduction Act in 2022 with the Medicare cap. Helping lower the cost here, biosimilars hitting the market and the huge profitability for GLP-1 drugs for Novo and Lilly https://www.reuters.com/business/healthcare-pharmaceuticals/sanofi-offer-all-insulin-products-35-per-month-us-2025-09-26/ XX A pill typically prescribed for rheumatoid arthritis and alopecia might help slow the progression of type 1 diabetes, a new study says. Baricitinib (bare-uh-SIT-nib) safely preserved the body's own insulin production in people newly diagnosed with type 1 diabetes.. and their diabetes started progressing once they stopped taking baricitinib, results show. They produced less insulin and had less stable blood sugar levels.   Baricitinib works by quelling signals in the body that spur on the immune system, and is already approved for treating autoimmune conditions such as rheumatoid arthritis, ulcerative colitis and alopecia, researchers said.   “Among the promising agents shown to preserve beta cell function in type 1 diabetes, baricitinib stands out because it can be taken orally, is well tolerated, including by young children, and is clearly efficacious,” Waibel said. “We are hopeful that larger phase III trials with baricitinib are going to commence soon, in people with recently diagnosed type 1 diabetes as well as in earlier stages to delay insulin dependence,” she added. “If these trials are successful, the drug could be approved for type 1 diabetes treatment within five years.”   Findings presented at medical meetings should be considered preliminary until published in a peer-reviewed journal.   https://www.usnews.com/news/health-news/articles/2025-09-23/pill-effective-in-slowing-type-1-diabetes-progression XX An existing transplant drug has shown promise in slowing the progression of type 1 diabetes in newly diagnosed young people, potentially paving the way for the first therapy that modifies the disease after diagnosis. The Drug, called ATG, is currently used together with other medicines to prevent and treat the body from rejecting a kidney transplant. It can also be used to treat rejection following transplantation of other organs, such as hearts, gastrointestinal organs, or lungs. The researchers studied 117 people aged five to 25, who'd been diagnosed with type 1 diabetes within the past three to nine weeks. The participants were from 14 centers across eight European countries and were randomized to be given different doses of ATG (0.1, 0.5, 1.5, or 2.5 mg/kg) or a placebo. ATG was given as a two-day intravenous (IV) infusion. The main goal was to see how well the pancreas could still make insulin after 12 months, measured by C-peptide levels during a special meal test. C-peptide is released into the blood along with insulin by the pancreas.   The findings are promising, showing that ATG, even at a relatively low dose, can slow the loss of insulin-producing cells in young people newly diagnosed with type 1 diabetes. The lower dose also caused fewer side effects, making it a more practical option. https://newatlas.com/disease/antithymocyte-globulin-newly-diagnosed-type-1-diabetes/     XX The FDA has delayed its feedback on Lexicon Pharmaceuticals' application to bring Zynquista (sotagliflozin) to people with type 1 diabetes. The agency had planned to respond this month but will now wait until the fourth quarter after reviewing new data from ongoing studies. Zynquista, an oral drug meant to be used with insulin, has already been approved for heart failure (marketed as Inpefa). But in type 1 diabetes, it faces safety concerns: last year an FDA advisory committee voted 11–3 that its benefits don't outweigh the increased risk of diabetic ketoacidosis (DKA). The FDA later issued a complete response letter rejecting the drug. Lexicon is still pushing forward, hoping its additional submissions will strengthen Zynquista's case for type 1 diabetes approval. https://www.biospace.com/fda/after-fda-rejection-lexicons-type-1-diabetes-drug-hit-with-another-regulatory-delay     XX A common but often undiagnosed genetic condition may be causing delays in type 2 diabetes diagnoses and increasing the risk of serious complications for thousands of Black and South Asian men in the UK—and potentially millions worldwide. A new study found around one in seven Black and one in 63 South Asian men in the UK carry a genetic variant known as G6PD deficiency. Men with G6PD deficiency are, on average, diagnosed with type 2 diabetes four years later than those without the gene variant. But despite this, fewer than one in 50 have been diagnosed with the condition.   G6PD deficiency does not cause diabetes, but it makes the widely used HbA1c blood test—which diagnoses and monitors diabetes—appear artificially low. This can mislead doctors and patients, resulting in delayed diabetes diagnosis and treatment.   The study found men with G6PD deficiency are at a 37% higher risk of developing diabetes-related microvascular complications, such as eye, kidney, and nerve damage, compared to other men with diabetes.   "This study highlights important evidence that must be used to tackle these health inequalities and improve outcomes for Black communities. Preventative measures are now needed to ensure that Black people, especially men, are not underdiagnosed or diagnosed too late." https://medicalxpress.com/news/2025-09-hidden-genetic-delay-diabetes-diagnosis.html XX Novo Nordisk today announced the resubmission of its Biologics License Application (BLA) to the US Food and Drug Administration (FDA) for Awiqli® (insulin icodec) injection, a once-weekly basal insulin treatment for adults living with type 2 diabetes. If approved, Awiqli® would become the first once-weekly basal insulin available in the United States, providing an alternative to daily basal insulin injections for adults living with type 2 diabetes.   The resubmission is based on results from the ONWARDS type 2 diabetes phase 3a program for once-weekly Awiqli® which is comprised of five randomized, active-controlled, treat-to-target clinical trials in approximately 4,000 adults with type 2 diabetes. The clinical program evaluated Awiqli® vs. daily basal insulin and the primary endpoint in these trials was change in A1C from baseline.1-5 Awiqli® is approved in the EU, along with 12 additional countries. In addition, regulatory filings have been completed in several other countries, with further regulatory decisions expected in 2025. XX Interesting news from Sequel Med Tech – they've signed an agreement with Arecor to pair the twiist pump with AT278 an ultra-concentrated (500U/mL), ultra-rapid insulin in development. They also have a deal with Medtronic to develop insulin for new pumps. This insulin isn't yet approved, it's 5 times stronger than standard fast acting  it's hoped that a clinical study will begin next year. Arecor says its insulin could potentially be the only option capable of enabling and catalyzing the next generation of longer-wear and miniaturized automated insulin delivery systems.   https://www.drugdeliverybusiness.com/sequel-arecor-develop-rapid-insulin-twiist/ XX Tandem Diabetes Care announes its t:slim X2™ insulin pump with Control-IQ+ automated insulin delivery (AID) technology is now cleared for use with Eli Lilly and Company's Lyumjev® (insulin lispro-aabc injection) ultra-rapid acting insulin in the United States (U.S.).   – The t:slim X2 insulin pump with Control-IQ+ technology is now cleared for use with Lyumjev for people with type 1 diabetes ages 2 and above and all adults with type 2 diabetes. The companies are continuing to work toward securing Lyumjev compatibility for the Tandem Mobi pump. https://hitconsultant.net/2025/09/29/tandem-diabetes-cares-tslim-x2-pump-cleared-for-use-with-lillys-ultra-rapid-lyumjev-insulin/ XX You can now place your order for the MiniMed™ 780G system with the Instinct sensor, made by Abbott. And if you are already a MiniMed 780G user, you can place an upgrade order today. ​This is a 15 day wear sensor, with no transmitter or overtape required. It looks the same at other Abbot sensors such as the Libre but is proprietary to Medtronic. Shipments are scheduled to start in November.   ​ https://www.drugdeliverybusiness.com/medtronic-launches-minimed-780g-instinct-abbott/   XX The global type 1 diabetes (T1D) burden continues to increase rapidly driven by rising cases, ageing populations, improved diagnosis and falling death rates. ,   The study estimates that T1D will affect 9.5 million people globally in 2025 (up by 13% since 2021), and this number is predicted to rise to 14.7 million in 2040. However, due to lack of diagnosis and challenges in collecting sufficient data, the actual number of individuals living with T1D is likely much higher, researchers say.   In fact, they estimate that there are an additional 4.1 million 'missing people' who would have been alive in 2025 if they hadn't died prematurely from poor T1D care, including an estimated 669,000 who were not diagnosed. This is particularly true in India, where an estimated 159,000 people thought to have died from missed diagnoses. The study predicts that 513,000 new cases of T1D will be diagnosed worldwide in 2025, of which 43% (222,000) will be people younger than 20 years old. Finland is projected to have the highest incidence of T1D in children aged 0-14 years in 2025 at around 64 cases per 100,000. The substantial increases in T1D forecasts between 2025 and 2040 underscore the urgent need for action. As co-author Renza Scibilia from Breakthrough T1D explains, "Early diagnosis, access to insulin and diabetes supplies, and proper healthcare can bring enormous benefits, with the potential to save millions of lives in the coming decades by ensuring universal access to insulin and improving the rate of diagnosis in all countries."   The authors note some important limitations to their estimates, including that while the analysis uses the best available data, predictions are constrained by the lack of accurate data in most countries-highlighting the urgent need for increased surveillance and research. They also note that data on misdiagnosis and adult populations remain limited, and the analysis assumes constant age-specific incidence and mortality over time. Furthermore, incidence data from the COVID-19 period were excluded from part of the modelling to avoid bias. Future updates are expected to improve as new data become available and applied. https://www.news-medical.net/news/20250919/New-study-warns-of-millions-of-undiagnosed-and-missing-people-with-type-1-diabetes.aspx XX A new study has found that semaglutide — the active ingredient found in some GLP-1 medications prescribed for diabetes and to aid weight loss — may help protect the eyes from diabetic retinopathy. Researchers estimate that as much as 40% of all people with diabetes also have diabetic retinopathy — a potentially blinding eye condition caused by blood vessel damage in the eye's retina. There is currently no cure for diabetic retinopathy. The condition is often managed through injections of anti-VEGF medications into the eye, surgery, and blood sugar monitoring and control. For this lab-based study, researchers used samples of human retinal endothelial cells that were treated with different concentrations of semaglutide. The cells were then placed in a solution with both a high glucose level and high level of oxidative stress — where there is an imbalance of antioxidants and free radicals — for 24 hours.   Past studies show that oxidative stress plays a role in the formation of diabetic retinopathy.   At the study's conclusion, researchers found that the retinal cells treated with semaglutide were twice as likely to survive than cells that were untreated. Additionally, the treated cells were found to have larger stores of energy.   Scientists also found that three markers of diabetic retinopathy were decreased in the semaglutide-treated retinal cells. First, the levels of apoptosis — a form of cell death — decreased from about 50% in untreated cells to about 10% in semaglutide-treated cells. The production of the free radical mitochondrial superoxide decreased from about 90% to about 10% in the treated retinal cells.   Researchers also found the amount of advanced glycation end-products — harmful compounds that can collect in people with diabetes and are known to cause oxidative stress — also decreased substantially.   Lastly, scientists reported that the genes involved in the production of antioxidants were more active in the semaglutide-treated cells when compared to untreated cells. Researchers believe this is a sign that semaglutide may help repair damage to the retinal cells.   “Our study did not find that these drugs harmed the retinal cells in any way — instead, it suggests that GLP1-receptor agonists protect against diabetic retinopathy, particularly in the early stages,” Ioanna Anastasiou, PhD, molecular biologist and postdoctoral researcher at the National and Kapodistrian University in Greece, and lead author of this study, said in a press release.   “Excitingly, these drugs may be able to repair damage that has already been done and so improve sight. Clinical trials are now needed to confirm these protective effects in patients and explore whether GLP-1 receptor agonists can slow, or even halt, the progression of this vision-robbing condition.” https://www.medicalnewstoday.com/articles/ozempic-semaglutide-may-help-protect-against-diabetes-related-blindness-retinopathy   XX Biolinq has received De Novo Classification from the U.S. Food and Drug Administration for its lead product, Biolinq Shine, a patch on the forearm that provides real-time glucose feedback through a primary color-coded LED display, visible with or without a phone. This one is tricky – it's called a needle free CGM but it also says it uses micro needles. By the way, De Novo isn't exactly the same as what we think of for FDA approval for medical devices. It's not as rigorous but it's a streamlined route for novel, low to moderate risk devices with no existing equivalent. We'll see how this one turns out. https://www.hmenews.com/article/biolinq-s-multi-function-biosensor-receives-fda-de-novo-classification

In this interview guidance was shared on diabetes-related complications and their prevention. It was explained that diabetes weakens the immune system, making patients more vulnerable to viral, bacterial, and fungal infections, which can become severe. COVID-19 was highlighted as a major example of this risk. It was emphasized that regular exercise, healthy diet, and maintaining control over blood sugar, blood pressure, cholesterol, and weight strengthens the body's immunity. On the question of the timing of medication, it was informed that time of consumption of glucose-lowering drugs differs for each drug. Some need to take it before meals, others after or few in between the meal. No changes should be made without consulting a doctor. The use of Continuous Glucose Monitoring (CGM) was recommended for consistent tracking of blood sugar levels, especially in those people who are on multiple doses of insulin therapy (e.g.T1DM and T2DM on insulin therapy), or those where glucometer readings don't match with HbA1c report, or those with recurring hypoglycemia, unawareness, etc. Expert- Dr Sunil Gupta Anchor- Mrs. Pranjali Bawaskar Podcast: 11/07/2025 Recorded at: Akashwani Nagpur Episode: 79

At the beginning of the program, Dr. Sunil Gupta explained that the complications of diabetes are of two types: acute complications, such as hypoglycemia (low blood sugar) and diabetic ketoacidosis especially in Type 1DM, both of which can cause sudden and immediate danger. Chronic complications develop slowly over time and affect the eyes, kidneys, heart, brain, and nerves. Hypoglycemia occurs when blood sugar falls below 70 mg/dl, and the main causes could be drug-induced, like insulin or sulfonylurea group of drugs, skipping of the meal, excessive exercise, vomiting or diarrhea, and due to use of drugs like painkillers (analgesics) or a few antibiotics along with glucose-lowering drugs. However, the risk of hypoglycemia has become lower with the use of newer medications compared to older ones. In response to audience questions, it was emphasized that the decision to stop or reduce medication should always be made under the supervision of a doctor. People with prediabetes (HbA1c 5.7–6.4%) can often avoid developing diabetes altogether through timely lifestyle changes. If diabetes runs in the family, the risk of children developing it at an early age is significantly higher. The importance of an annual health check-up covering the eyes, heart, kidneys, and feet was stressed, described as the “greatest gift” a person with diabetes can give themselves is of “Good Health.” When anemia coexists with diabetes, fatigue and complications tend to worsen, making it essential to identify the underlying cause and provide treatment. In cases of leg pain or neuropathy, vitamin deficiencies, blood vessel health, and side effects of a few medicines like statin should all be carefully evaluated. Expert- Dr Sunil Gupta Anchor- Mrs. Kalyani Gokhale  Podcast: 27/06/2025 Recorded at: Akashwani Nagpur Episode: 78

Diabetes is a metabolic risk which weakens immunity, making patients more susceptible to viral, bacterial, and fungal infections, and increasing the severity of illnesses like what we have seen during COVID-19 pandemic. It is important to control blood sugar, blood pressure, cholesterol, and weight to strengthen the body's defense system. Patients should pay attention to medication timing, blood glucose monitoring, and assess hypoglycemia risks. Diabetes-related complications include retinopathy, cataract, glaucoma, gum infections, neuropathy, kidney disease, and cardiovascular risks, highlighting the need for preventive eye checkups, foot care, early recognition of symptoms, and lifestyle modifications such as regular exercise, avoiding smoking/alcohol, and a healthy diet. A practical A–H formula for long-term diabetes care can be followed: ● A is for HbA1c (target < 7%) A1C ● B for blood pressure (target

The relationship between diabetes and obesity was explained in simple terms, highlighting how excess weight leads to insulin resistance. As obesity increases, the effect of insulin in the body decreases. To compensate, the pancreatic beta cells have to work harder to maintain normal blood sugar. Over time, this constant strain on beta cells causes beta cell fatigue and eventual failure. Insulin is secreted from beta cells in two phases. The first phase of insulin release covers the postprandial spike of glucose, while the second phase continues its action for 4–6 hours. In type 1 diabetes, both these phases of insulin release are absent, which is why insulin replacement becomes absolutely necessary. While in T2DM, the first phase of insulin is lost, causing postprandial hyperglycemia. Dr. Gupta emphasized that HbA1c alone cannot provide a complete picture of diabetes control. While it reflects the average sugar level, it does not capture dangerous fluctuations. Glycemic variability—frequent ups and downs in sugar—poses a high risk, and therefore continuous glucose monitoring (CGM) is extremely valuable. CGM not only shows the average but also the trends and time-in-range, helping patients and doctors achieve better stability. Dr. Kavita Gupta mainly focused on lifestyle and diet management. She explained the benefits of intermittent fasting and early dinner, pointing out that heavy meals late at night increase both sugar and weight. She suggested the “plate method” of eating: half the plate vegetables, one-fourth pulses or proteins, and one-fourth complex carbohydrates. She emphasized salads, sprouts, yogurt, and the importance of portion control. Addressing common confusion about fruits, she clarified that diabetic people can safely eat seasonal fruits in moderation, as long as juices are avoided and quantity/timing are considered. She also recommended a light “pre-dinner snack” such as fruit between lunch and dinner to prevent hypoglycemia and curb junk food cravings. Her overall message was clear: balanced diet, correct timing, and mindful eating are essential pillars of diabetes care. Expert- Dr Sunil Gupta & Dr Kavita Gupta Anchor- Mrs. Kalyani Gokhale Podcast: 23/05/2025 Recorded at: Akashwani Nagpur Episode: 76

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Chrissy: Hi dr Cabral Is it ok to that estrogel and progesterone for menopause if you have lymphoedema ? Or will it make it worse .. kind regards Chrissy                                                                                                                                                    Kay: Hi Dr. Cabral- What are your thoughts on Metformin combined w Naltrexone topiramate and Vit B12 for Tx of PCOS? My 31 y.o. daughter has tried over the last few years to manage her PCOS w traditional Chinese herbs, acupuncture, yoga & pilates which have only given her limited success. Her HbA1c were in the pre-diabetic range. She lives in the NYC area w a demanding job. Now, working w a Functional Med provider, her tests showed high levels of cortisol throughout the day & hormonal imbalances. Weekend hikes & being near nature on occasion have helped her stress levels as shown by her Oura ring data. After about a month of the Rx regimen, she has noticed an improvement in her HbA1c and has hired a personal trainer. For true, sustainable wellness, what do you recommend?                                       Becky: Hi Dr. Cabral! Thank you for ALL that you do and thank you for using your story to help heal others! I am an IHP2 and need advice. I am working with a client, she is in her mid 30s and she has had horrific breath and overall dryness of her entire body since a child. Her dad and siblings have the same issues along with her oldest daughter. She has tried EVERY imaginable product to fix her breath with zero success. She has done the 21 day detox, & is finishing up the CBO Protocol with H.Pylori & will be starting the Finisher. She did a HTMA last year with someone else but nothing alarming. She is hopeless that her breath can't be fixed. What is your suggestion as to what direction we should go next? She does not drink filtered water, is on birth control & an anti depressant. THANKS!!!!            Kayley: I am 24 yrs old 5'2" 123lbs. I have diagnosed Rheumatoid Arthritis that has severely impacted my life. I currently take Methotrexate, Plaquenil, Folic Acid, and Folinic Acid. I am struggling with debilitating fatigue, and my IBS has recently flared up. Is there anything you would suggest doing to improve energy levels?                               Amanda: Does chiropractic treatment benefit children diagnosed with ADHD?     Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3509 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

This week we Baylee is bringing you part 2 of our understanding your labs series. This episode she is diving into fasting insulin, HbA1c and CRP and why these are important lab markers. If you have questions, or topics that you want to hear about, head over to our Instagrams https://www.instagram.com/bayleethedietitian/ or https://www.instagram.com/brianna.dietitian/ and send us a DM! You can also follow the podcast https://www.instagram.com/mocktailminutes/Featured Mocktails: Just Ingredients Poppi  Click play, sip back, and be empowered.

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Suzanne: Thank you for your time in advance. In late 2021, my husband was diagnosed with Stage IV prostate cancer. He underwent six rounds of chemo along with Eligard injections. After his last scans, whole body and bone, we were told the cancer is "stabilized". He is currently on 300 mg of Nubeqa 2x a day (down from 4 x because I asked about it) and Lupron injections every 3 months. We have consciously changed our diet (no added sugar, no alcohol, no processed foods) and he is doing pretty well, although, he does fatigue and sweat easily. My question is whether you believe that taking a couple of your home tests would be beneficial for him? I worry about these powerful drugs he is being given and have noticed a reluctance from the doctor about reducing his drugs any further. Thank you again!                                                Sheena: Hi Dr C! Hope you and your team are well. I recently went for blood work. I fasted for 14 hours and was wondering what your thoughts are specifically regarding my Lipid Panel and Iron Panel. My triglycerides is 1.83, Total 4.05, HDL 1.72 and LDL 1.63 (all mmol/L). For iron my levels are 37 umol/L, iron binding 0.70 umol/L, and ferritin 44 ugL. My Dr says she's concerned with my triglycerides. How can I lower it? And shes concerned with my ferritin and iron levels so shes sending me for a Hemochromatosis blood test to see why the levels are off. (My fasting glucose is 4.9, hbA1c is 5.2, TSH is 1.04 and Auto CBC is 3.8). Would love your thoughts and any food and supplementation recommendations would be appreciated! Love you and all the best to everyone on their health journey!                                                            Madhia: Hello My Dr is giving me a hard time to prescribe MRI for my breast exam. Do you have any Dr you can recommend that would help me in greater Los Angeles area?                                                                                                 Margie: My son, who is 46 years old has had Alpha-Gal for approximately 10 years. Now his wife has also been diagnosed with it. I am aware it is caused by a tick bite. He constantly has mass cell inflammation including breathing and allergy issues. Could you please explain specifically how this disease affects the body's immune system and which of your protocols should be used to bring the body back into balance. Will that particular protocol bring the body back into balance enough so that it will relieve the mass cell inflammation and they can return to eating mammal meat?                                                     Jackie: Hi Dr. Cabral thank you for all that you do. You have made a tremendous impact in my and my clients lives. My husband has just finally been diagnosed after 10 years of misdiagnosis with neurogenic TOS. We have a great rehab team working on the biomechanics and we are exploring Big 5 root causes. I was wondering what natural pain management methods you would recommend during the process pain is 10/10 and conventional medicines wants to basically kill the nerve or put him on Lyrica which neither are an option for us. We are exploring accupuncture, grounding and adrenal sooth/inflammasoothe/cbd protocol. Any other alternative inflammation reduction techniques or devices you would recommend? Could you do a podcast on natural pain management strategies for people with chronic pain?          Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3495 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Did you know strength training can do more for type 2 diabetes than medication ever could? Amy Hudson and Dr. James Fisher continue their series on the benefits of strength training and reveal how powerful it can be for managing—and even reversing—type 2 diabetes. They break down why excess sugar builds up in the bloodstream, how your muscles play a critical role in blood sugar control, and what kind of training yields real, measurable results—without needing extreme diets. If you—or someone you know—is dealing with type 2 diabetes, this is an episode you won't want to miss. Dr. Fisher defines type 2 diabetes: it's a condition where the body becomes unresponsive to insulin, leaving glucose floating in the bloodstream instead of being stored and used properly. Dr. Fisher breaks down how insulin resistance begins. When your body stops reacting to insulin's signal to store sugar, it starts a cascade of health issues that lead to type 2 diabetes. According to Dr. Fisher, over 422 million people worldwide have diabetes, and the disease causes at least 1.5 million deaths every year. Dr. Fisher highlights how diabetes is largely lifestyle-driven. That means many cases are preventable or reversible with the right habits—especially consistent exercise and dietary awareness. Amy poses the big question: Is sugar intake or lack of exercise the real issue? Dr. Fisher explains that both matter—but without regular movement, even a modest diet can lead to sugar overload and poor glucose control. If you're not actively burning glucose through movement, even a “normal” Western diet is likely giving you far more sugar than your body can handle. Strength training is a powerful tool against diabetes. Studies show it reduces waist size, body fat, blood pressure, cholesterol, and most importantly, HbA1C—the key marker of blood sugar control. Amy reminds us that it's easy to believe you need drugs or extreme diets, but strength training alone can help manage your blood sugar levels. Dr. Fisher outlines the most effective approach to strength training. The best results came from lifting moderate to heavy weights (over 60% of one-rep max) with high effort, two to three times per week. Why intensity matters more than duration. You don't need long workouts—you need focused, high-effort sessions that push your muscles to adapt and grow stronger. Amy makes an encouraging observation about habit stacking. When people begin exercising, they often naturally start eating better, sleeping more, and making other healthy choices. Dr. Fisher shares results from a large meta-analysis covering 1,100 people. The most impactful programs were progressive—meaning the weight and difficulty increased over time, keeping the body challenged. Why working with a personal trainer or a supervisor can accelerate your progress. Supervised sessions ensure your workouts are safe, structured, and progressively harder. The academic consensus is crystal clear. Strength training helps regulate blood sugar, reduce HbA1C, improve insulin sensitivity, and may even reverse type 2 diabetes in certain cases. Amy offers a compelling reason to start now. Even if you're healthy, strength training provides peace of mind that you're protecting yourself against future metabolic diseases. Dr. Fisher shares his 80/20 approach to eating. He focuses on clean, whole foods 80% of the time and gives himself the freedom to enjoy things like cookies and chips without guilt the other 20%. Amy reminds us that healthy living isn't about being flawless—it's about staying consistent and doing your best most of the time, even if you stumble occasionally.     Mentioned in This Episode: The Exercise Coach - Get 2 Free Sessions! Submit your questions at StrengthChangesEverything.com     This podcast and blog are provided to you for entertainment and informational purposes only. By accessing either, you agree that neither constitute medical advice nor should they be substituted for professional medical advice or care. Use of this podcast or blog to treat any medical condition is strictly prohibited. Consult your physician for any medical condition you may be having. In no event will any podcast or blog hosts, guests, or contributors, Exercise Coach USA, LLC, Gymbot LLC, any subsidiaries or affiliates of same, or any of their respective directors, officers, employees, or agents, be responsible for any injury, loss, or damage to you or others due to any podcast or blog content.

0:00- Intro 1:00- Fasting glucose and HbA1c 24:00- Bryan's high energy flux experiment 27:30- Low volume training  36:00- Libido and dieting 38:00- Back to volume  48:00- Aaron's PED use and competing 

It's been a hot minute but Ami Bennett (or should that be Dennett?) is back for a catch up!My dear friend and fellow type 1 Ami returns to give us the latest on her diabetes escapades.There's a lot to catch up on, as Ami's quest for a lower HbA1c has given her a few tales. I discuss the brave new world of tangles that come with a tubed insulin pump, Ami's been dealt a dia-fine and we accidentally invent the Diabetes Girl Guides. Plus, does anyone name their insulin pump? Asking for two friends...CONNECT WITH AMI:Follow Ami on Instagram.JOIN THE TYPE 1 ON 1 COMMUNITY:Come and say hi @studiotype1on1 on Instagram.Visit the Type 1 on 1 website.Subscribe to the Type 1 on 1 newsletter.DISCLAIMER Nothing you hear on Type 1 on 1 should be taken as medical advice. Please consult your healthcare team before making any changes to your diabetes or health management.SPONSOR MESSAGE This episode of Type 1 on 1 is sponsored by Dexcom. Using Dexcom CGM has given me so much confidence to make informed diabetes treatment decisions in the moment.You can choose to wear it on your arm or your abdomen, and all Dexcom CGMs have the share and follow feature even when connected to an insulin pump, so family and friends can see your glucose levels and get alerts, giving that extra bit of support when needed.Head to Dexcom.com to request a free Dexcom ONE+ sample.Always read the user manual for important product aspects and limitations. Talk to your doctor for diabetes management terms and conditions and terms of use. 

Grip strength is a powerful predictor of longevity, linked to lower risks of cancer, heart disease, and all-cause mortality. Jain discusses Goodhart's Law and suggests a holistic approach to health, incorporating compound weightlifting, cardio, mobility exercises, and other health measures like waist-to-hip ratio, HbA1c, and lipids. The key takeaway is that grip strength is a side effect of a healthy, active lifestyle, not the cause of longevity. Get full access to Evolving with Nita Jain at www.nitajain.com/subscribe

Ever wondered why a molecule as simple as hydrogen could influence everything from Parkinson's to metabolic syndrome? We explored how molecular hydrogen selectively targets only the most harmful free radicals while leaving beneficial ones alone, making it fundamentally different from every other antioxidant supplement gathering dust in your cabinet.The six-month metabolic syndrome study particularly caught my attention: participants drinking hydrogen water saw improvements in glucose levels, HbA1c, inflammation markers, and even lost weight – with no diet changes or exercise requirements.Tyler breaks down why those expensive alkaline water machines aren't doing what you think (spoiler: it's not about pH), why hydrogen inhalation requires serious safety considerations, and exactly how to dose hydrogen water for maximum benefit.And on top of all this, we tackle why this primordial molecule – literally present since the beginning of the universe – seems almost designed to work with human biology, and why megadoses of vitamins C and E can actually harm exercise performance while hydrogen acts as a fine-tuning modulator.Timestamps:0:00 Hydrogen's effects on major diseases2:45 Six-month metabolic syndrome study results5:15 Hydrogen only targets toxic radicals6:08 Divine properties of hydrogen molecule10:12 Basic chemistry of oxidation and reduction15:30 Dangers of excessive antioxidants23:45 How hydrogen modulates antioxidant systems47:20 Hydrogen production in your gut56:30 Inhaled vs drinking hydrogen water61:15 Explosive dangers of hydrogen inhalation71:30 Therapeutic dosing for hydrogen water85:45 Debunking alkaline and structured water94:30 Tyler's elite athletic performance secretsDisclaimer:Dr. Paul Saladino received his medical degree from the University of Arizona Medical School. His use of "doctor" or "Dr." in relation to himself solely refers to that degree. Dr. Saladino is a licensed physician in California, but he no longer practices in any state and does not see patients so he can focus on educating people full time.This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, or prescription. It does not create a doctor-patient relationship between Dr. Saladino and you. Always consult your physician before making any health decisions.

It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: Sernova has a new partner and a new drug for cell transplants, at home glucose/T1D test research, study looks at best diet for people with type 2, Lifescan files for banktrupcy, T1D Barbie and more! Find out more about Moms' Night Out  Read Hangy Woman's take on Barbie (and send me yours!)  Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom   Check out VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Reach out with questions or comments: info@diabetes-connections.com Episode transcription with links: In the News July 18   Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. XX Sernova is partnering with Eledon Pharmaceuticals to test a new immunosuppressive drug in its ongoing clinical trial for people with type 1 diabetes (T1D). The drug called tegoprubart is designed to protect transplanted islet cells without harsh side effects. The current treatment is known for its potential toxicity, especially towards insulin-producing beta cells, and its adverse side effects, making it less than ideal for islet cell therapy in T1D. Tegoprubart has already shown promise in earlier trials, helping T1D patients achieve insulin independence with better graft survival and fewer side effects. This next phase of Sernova's trial (Cohort C) will combine Eledon's drug with Sernova's Cell Pouch, an implantable device that houses insulin-producing cells. In earlier phases, six participants stopped needing insulin completely, with results lasting years. Sernova also plans to use stem cell-derived islet-like clusters from partner Evotec to create a next-gen therapy. If all goes well, a new clinical program could launch in 2026.   https://www.streetwisereports.com/article/2025/07/15/biotech-partnership-to-revolutionize-diabetes-treatment.html XX Researchers at Yale School of Medicine, funded by Breakthrough T1D, are evaluating GTT@home, a new finger-prick, at-home glucose tolerance test, to monitor early-stage type 1 diabetes (T1D) in individuals with T1D autoantibodies. Developed by Digostics (Dih-jos-tiks), the test offers a simpler, less invasive alternative to clinic-based oral glucose tolerance tests. The study aims to assess its accuracy, usability, and acceptance, potentially paving the way for wider use in early T1D detection and monitoring. The results of the trial will inform future regulatory submissions for GTT@home use in T1D, which already has regulatory approval in the UK, Europe and other regions for other types of diabetes. https://finance.yahoo.com/news/digostics-announces-university-trial-home-164300142.html XX LifeScan announced that it entered into a restructuring support agreement and, to implement it, filed for chapter 11 bankruptcy. As the process moves forward, LifeScan plans to operate in the ordinary course of business. It expects to emerge from chapter 11 by the end of the year. LifeScan develops the OneTouch Bluetooth-connected blood glucose meter and mobile diabetes app that provide simplicity, accuracy and trust in diabetes management. XX New study looks at quality of life and cost of AID systems. This was done in Finland which has the highest prevalence of T1D in the world. The results show automated insulin delivery pumps significantly improved quality of life and reduced diabetes-related complications. The quality-adjusted life expectancy increased by an average of 2.3 years for individuals using an automated insulin delivery pump. Although the overall costs of automated insulin delivery pump treatment were higher than those of conventional insulin pump treatment, its cost-effectiveness ratio was well below the generally accepted willingness-to-pay threshold of 50,000 euros in Finland. This is the first cost-effectiveness study of automated insulin delivery pumps conducted in Finland. https://medicalxpress.com/news/2025-07-automated-insulin-delivery-effective-treatment.html XX Blue Circle Health expands into the 11th state: Louisiana! This is Free, comprehensive virtual clinical care, education, and support program for adults with type 1 diabetes In addition to serving adults with type 1 diabetes in Louisiana, our program is also active in Alabama, Mississippi, Florida, Missouri, Iowa, Ohio, Vermont, New Hampshire, Maine, and Delaware.  The program serves as an extension of participants' existing care teams and ensures continuity of care The organization hopes to inform new care models and policies that remove barriers to healthcare People with T1D over 18 years of age who speak English or Spanish are eligible to enroll. To sign up directly, refer a person living with T1D, or learn how you can partner with Blue Circle Health, visit www.bluecirclehealth.org. XX A new study comparing three popular diets—intermittent fasting, time-restricted eating, and continuous calorie cutting—found that all can help people with type 2 diabetes lose weight and lower blood sugar. But one diet stood out: the 5:2 intermittent fasting plan, where participants eat normally five days a week and restrict calories on two. It led to better results in fasting blood sugar, insulin response, and sticking with the plan. Although researchers identified improved HbA1c levels, and adverse events were similar across the three groups, the IER group showed greater advantages in reducing fasting blood glucose, improving insulin sensitivity, lowering triglycerides, and strengthening adherence to the dietary interventions. https://www.sciencedaily.com/releases/2025/07/250715043351.htm XX MIT students have developed an implantable device.. for use during emergency low blood sugars.   The new implant carries a reservoir of glucagon that can be stored under the skin and deployed during an emergency — with no injections needed.   The researchers showed that this device could also be used to deliver emergency doses of epinephrine, a drug that is used to treat heart attacks and can also prevent severe allergic reactions, including anaphylactic shock. The device contains a powdered form of glucagon and can be remotely triggered—either manually or automatically by a glucose monitor—to release the hormone when blood sugar drops too low. No word on next steps to make this commercially available.   https://news.mit.edu/2025/implantable-device-could-save-diabetes-patients-low-blood-sugar-0709 XX We've covered T1D1 before, this is an insulin calculator app – there's more to it than that.. it was created by 13 year old Drew who lives with type 1, but removed from the apps stores a few years ago, along with other non fda cleared apps. Drew who is now 18, Tells us they just submitted to the FDA and are optimistic about being reinstated. https://www.instagram.com/t1d1app/ XX   XX 1'm Brodie Sargent, a Type 1 diabetic raised in Mudgee, NSW, and currently living in Wollongong.   Starting August 26th, I'll be running a marathon every day for 26 days, and on the 27th day, I'll be finishing with Western Sydney's Half Ironman.   The current world record for the most consecutive marathons run by a Type 1 diabetic male is 25 and I'm aiming to break it.   I'm doing this to inspire others, diabetic or not, to challenge themselves and not let anything hold them back.   Any donation is greatly appreciated and supports a cause I truly believe in. The Type One Foundation focuses on support, connection, awareness, and advocacy for diabetics across Australia. They run online and in-person events for diabetics and their families, and also offer care packages to those newly diagnosed.   I was diagnosed at 15, and it was a tough time for me and my family, we had no history or understanding of diabetes. I was already a shy and awkward kid, and I struggled to speak up about how much it affected me. I started running with my roommate just to kill time but it quickly took over my life. Feeling stuck and unsure where I was heading, I decided to make a change and try to help anyone out there feeling the same way.   You can follow my journey on Instagram: @typerun_   XX Launched during children's congress To further promote inclusivity and tackle the stigma associated with the condition, Mattel partnered with Breakthrough T1D, a global organization dedicated to type 1 diabetes research and advocacy, to launch its first Barbie with type 1 diabetes. This partnership marks a major milestone in Mattel's commitment to greater representation, and highlights Breakthrough T1D's pivotal role in ensuring visibility for the type 1 diabetes community.   The doll is part of the Barbie Fashionistas line and includes key diabetes management tools modeled accurately with the help of Breakthrough T1D. The type 1 diabetes Barbie wears a continuous glucose monitor (CGM) secured with Barbie-pink, heart-shaped tape, and has an insulin pump at her waist. She also comes with a CGM-tracking smartphone, a pastel blue purse, and a blue polka dot outfit – blue being the color that symbolizes global diabetes awareness.   As part of a broader initiative to elevate voices in the type 1 diabetes community, Barbie also partnered with two global role models living with type 1 diabetes: Peloton Instructor Robin Arzón and model Lila Moss.   Robin Arzon Barbie Image Credit: Breakthrough T1D and Mattel Mattel's one-of-a-kind doll based on Arzón features her signature yellow outfit and a crown-shaped CGM on the back of her arm.   In interviews, Moss has highlighted the positive impact that the type 1 diabetes Barbie's visibility has already had, saying she receives daily messages from young people who feel less insecure about wearing their diabetes devices thanks to her public advocacy.   When Linxi Mytkolli, director of patient engagement at Diabetes Action Canada and person with diabetes, heard about the new “Dia Barbie,” she said she teared up.   “I grew up loving dolls, but I never saw one that reflected the reality I now live with – until Dia Barbie. Seeing a doll with a CGM, insulin pump, and even heart-shaped medical tape felt surreal. It's playful, powerful, and personal all at once,” said Mytkolli.   Mytkolli also emphasized that representation and visibility in toys and media can help chip away at shame.   “I've heard from so many people, especially those diagnosed in childhood, who delayed using tech like pumps or CGM because it felt like a punishment. Visibility in toys helps normalize these devices and makes kids feel like they're not alone or ‘othered.' It turns stigma into something softer – something that can be talked about, shared, even celebrated,” Mytkolli said.   And its impact goes beyond people living with diabetes. Laura Pavlakovich, who is the founder and CEO of You're Just My Type and has lived with type 1 diabetes since age five, shared that this representation is equally crucial for those without diabetes, as it demystifies the condition and challenges stereotypes.   “This kind of representation builds a vital bridge of empathy, illustrating that living with diabetes is simply a part of life for millions. It's an essential tool for educating the public and cultivating a more inclusive and supportive society for everyone,” said Pavlakovich.   Pavlakovich shared her personal experience of growing up with diabetes and how this will provide validation for those with the condition who often feel unseen.   “I vividly remember growing up with a 'my twin' doll, custom-made to look just like me, yet she always lacked the crucial part of my daily reality: an insulin pump. To finally see a Barbie, an iconic figure in childhood play, accurately depict someone living with type 1 diabetes, complete with her devices and pump, is truly a monumental moment,” said Pavlakovich.   To celebrate the launch, Barbie donated dolls to the Breakthrough T1D 2025 Children's Congress in Washington, D.C., where 170 young advocates for type 1 diabetes from around the world met with lawmakers to raise awareness. Priced at $10.99, the doll is now available on Mattel Shop and at retailers nationwide.   While this is a huge win for enhancing the representation of children living with diabetes, it doesn't end there. There is still significant work to be done to improve access to diabetes medication and technology.   “It is not lost on me that Barbie has more access to diabetes tech than many, if not most, people with diabetes globally,” said Mytkolli. “Representation and access – we deserve both.”   By bringing a common but misunderstood condition into children's toy boxes, the new type 1 diabetes Barbie is more than a toy. It's a symbol of pride, visibility, and the message that children with diabetes can live full, empowered lives.   As Mytkolli said, “Whether a child is living with diabetes, or loves someone who is, this doll quietly says, ‘You're not broken. You belong.'”