Podcasts about 25d

Tim D'Alfonso has constructed an excellent Monday crossword -- his debut! -- with a smile-inducing theme and some fun cluing, including 42D, Your of yore, THY; 43D, Start of a donkey's bray, HEE; and the nostalgia-inducing 25D, ________ Sketch (classic toy), ETCHA. This was a great puzzle and likely a confidence-builder for those just starting to do the NYTimes crosswords, we approve: 5 squares on the JAMCR scale.Show note imagery: Dame Judi DENCH, as M, in SkyfallWe love feedback! Send us a text...Contact Info:We love listener mail! Drop us a line, crosswordpodcast@icloud.com.Also, we're on FaceBook, so feel free to drop by there and strike up a conversation!

Today's crossword had a fine theme -- discussed herein -- but the rest of the clues also did their part. We particularly enjoyed 4D, Lady Gaga hit included on Rolling Stone's "500 Greatest Songs of All Time" list, BADROMANCE (BADROMANCE, but great song!); 59A, Occam's _________, RAZOR (when you need to trim a conspiracy theory down to size); and the slightly perplexing 25D, Field for a voice major, maybe OPERA (

On this episode of "Flight Training The Way I See It" we share helpful, insightful, updates to the following below:

Today's crossword, by veteran cruciverbalist Paolo Pasco, had its ups and downs, but that was by design, and the payoff - which we discuss in today's episode but don't want to spoil by revealing here - was an absolute delight. The clues were on the trickier side, as befits a Thursday - 33D,  So called "African Unicorn", OKAPI, comes to mind (well, it does now ...), as does 25D, Noted feature of "The Brothers Karamazov", EPILOG, and 48D, Lake that feeds the Truckee River, TAHOE (who? what? where?). All in all a fine piece of work, clearly worthy of the Paolo Pasco imprimatur, we give it 5 squares on the JAMCR scale.Contact Info:We love listener mail! Drop us a line, crosswordpodcast@icloud.com.Also, we're on FaceBook, so feel free to drop by there and strike up a conversation!

This week on the Think Fit Be Fit podcast Jenn Schwartz and Angela Damolin speak with Robert Jacobs, a world-renowned strength coach and the founder of Outlaw Strength. Rob discusses the importance of circadian rhythm and its impact on overall health and fitness. He explains how non-native electromagnetic radiation can disrupt circadian rhythms and mitochondrial function. Rob also debunks the myth of training according to the menstrual cycle and emphasizes the importance of listening to your body and adjusting your training accordingly. Additionally, he provides insights into the potential risks and benefits of taking supplements like NSAIDs and vitamin D.Topics discussed:Importance of circadian biology and its impact on performanceHow swelling of mitochondria leads to fluid displacement and changes in signalingNon-native EMF Hormone cycles and training Difference between feeling better and being better Making appropriate associations between symptoms and causesThe role of the 25D molecule in the bodySUBSCRIBE: Subscribe to the podcast to make sure you never miss an episode.You can find us on a variety of podcast apps:SpotifyPandoraiHeartRadioAmazon MusicTuneInGoogle podcastsConnect with Jennifer Schwartz:Studio websitePersonal WebsiteInstagramYouTubeConnect with Angela:https://www.instagram.com/rethinking_fitness/Connect with Rob Jacobs:website: www.outlawstrength.commembership site: outlawstrength.thinkific.comIG: @robertcjacobsSupport the Show:Hydrogen is used by health professionals as a powerful antioxidant and the #1 tool to fight inflammation. Studies show therapeutic potential in cancer, diabetes, digestive and heart issues, and essentially every organ and system in the body. Because hydrogen is the smallest molecule in existence, it can pass through the cell membrane and even the blood brain barrier to clear out inflammation and free radical damage where other antioxidants just can't get to.

A very challenging Thursday crossword by a veteran NYTimes cruciverbalist, aka David J. Kahn. Jean managed to get through it in close to her usual time, hardly breaking a 25D, Drops in the gym?, SWEAT; Mike did eventually solve the puzzle, but was surprised when he finally stumbled upon the final, vital correct answer in the SE corner, never a good sign.For those of you who want to check out today's crossword, fully solved, xwordinfo.com has your back.Contact Info:We love listener mail! Drop us a line, crosswordpodcast@icloud.com.Also, we're on FaceBook, so feel free to drop by there and strike up a conversation!

A nice Tuesday crossword by Taylor Johnson and the indefatigable Jeff Chen, with an almost-under-the-radar theme, and some quality clues, including 25D, Jackapoo or schnoodle, DOG (in the running for the best-clue-involving-a-DOG award, which we just totally made up but still want to confer on the authors); the educational 52D, The "Z" of ZIP code, ZONE (huh!); and 28D, Scientist on one side of the "War of the Currents", TESLA (not, as Mike had originally theorized, the muppet BEAKER).In other news, it's Triplet Tuesday, and Jean does ... well, we'll keep you in suspense - to find out how Jean did, download, listen up, and, as always, enjoy!Speaking of Jeff Chen, you can wander over to his website to check out the fully solved version of today's puzzle.Contact Info:We love listener mail! Drop us a line, crosswordpodcast@icloud.com.Also, we're on FaceBook, so feel free to drop by there and strike up a conversation!

A fine Friday crossword by Juliana Tringali Golden, with arguably the most interesting clue of the month, 53D, Country where almost half the world's zippers are made, JAPAN (wow!). Of course, there were many other worth pondering -- 25D, Yawl pole, MAST (say what?), 59A, Immediate threat to capture in a game of Go, ATARI (OK, if you say so), and 55A, "Platoon" but not "Dunkirk", IAMB (possibly the most NYTimes-ish crossword clue ever).  All in all a great crossword, 5 squares on the JAMCR scale for sure!

ಮುತ್ತಿನ ಹಾರಗಳು, 25D. KANNADA - ಕನ್ನಡ

What is the function of the vitamin D receptor (VDR)? How does it interplay with the retinoid receptor (RXR)? What happens to your thyroid function when you supplement D3 and drive up your 1,25D levels? Can supplementing D3 drive the development of osteoporosis? Why does the half-life of 25D and 1,25D matter? Why do you never hear the word "heterodimerization" in vitamin D smurf talk? What is a dimer?  Vitamin D researcher Jim Stephenson Jr shares his research and dot connections about hormone D supplementing and the effects that it has to cause imbalance in our body. He challenges listeners to dig deeper beyond two or three molecules and to realize the complexity of secosteroid hormone D. We go down the list point-by-point of a popular pro vitamin D3 article written by researcher Danny Roddy with the goal of bringing clarity to the discussion. We cover oral versus topical administration of D3 and explore the question: how would a substrate lower one of the potentials that it can become?  Jim's Facebook group: https://www.facebook.com/groups/517807781731760 The pro D3 supplement article: https://dannyroddy.substack.com/p/vitamin-d-bioenergetic-wunderkind The Man Who Sold America On Vitamin D — And Profited In The Process https://khn.org/news/how-michael-holick-sold-america-on-vitamin-d-and-profited/ Dr Hollick's Vitamin D supplement: https://shopee.ph/FERN-D❤%EF%B8%8F-Your-DAILY-SUNSHINE-VITAMINS-i.110227573.2088103398 The renin–angiotensin–aldosterone system and calcium-regulatory hormones  https://www.nature.com/articles/jhh2014125.pdf?origin=ppub Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: a meta-analysis and GRADE assessment of cohort studies and RCTs https://nutritionj.biomedcentral.com/articles/10.1186/s12937-021-00744-y?fbclid=IwAR0iC-NWzVOXsX3PQfqpa-zXYuQqvUZwUmwP-ymNwhT4XLU46ovYimbU_VA Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595834/?fbclid=IwAR3vuqTiEt7LlGDA4JKBWNiy84vUQH1kMrjZR7bkragBW_j9NYDfZ-lQv5M Vitamin D4 in Mushrooms https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411670/?fbclid=IwAR3VA9RAwSVm5eLT_Vh1PSZBgf1sqOWb-TyZ-hRWELNEaokTh6aRRkOhs98 Photobiology of Vitamin D in mushrooms and its bioavailability in humans https://pubmed.ncbi.nlm.nih.gov/24494050/ Trevor Marshall PhD published research: https://www.trevormarshall.com/papers.htm Steroid Hormone Vitamin D: Implications for Cardiovascular Disease https://pubmed.ncbi.nlm.nih.gov/29798901/ 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions https://pubmed.ncbi.nlm.nih.gov/18541563/ Vitamin D in Mushrooms https://www.ars.usda.gov/ARSUserFiles/80400525/Articles/AICR09_Mushroom_VitD.pdf Absence of Seasonal Variation in Serum Concentrations of 1,25-Dihydroxyvitamin D Despite a Rise in 25-Hydroxyvitamin D in Summer https://academic.oup.com/jcem/article-abstract/53/1/139/2677695?redirectedFrom=fulltext&fbclid=IwAR2zY9zb43zc66cLY6b50zbhtbCOThYN-CRw2K8YK5LwSm8xeGm5mqM7zdQ Vitamin D: the alternative hypothesis http://autoimmunityresearch.org/transcripts/AR-Albert-VitD.pdf My website: www.matt-blackburn.com Mitolife products: www.mitolife.co  

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks… Let's get started!    Nadia: Dear Doctor Cabral, thank you so much for all you do to help the community and for your very interesting podcast! I would like to ask if you could indicate me in which direction we could look regarding my dad's health. He is 62 years old, 5feet7 and weighs now less then 125 pounds. He has always been thin (even though he eats 3 times more then the rest of the family) but muscular. But now he really has just skin on his bones even though he still eats a lot (and healthy). He goes to the bathroom at least once a day, sometimes after every meal, which is very good. And his blood work came back normal. He's been trying to gain weight for years but he just gets more and more skinnier and is pretty preoccupied. He is very active all day, always working around the house, in the garden, loves hiking and biking. A Nutritionist told him years ago that it will be impossible for him to gain weight and that it's much easier for overweight people to lose weight. Do you have any advice on how my dad could get to a normal weight again or what we should look at? Thanks so much for your time and help, Have a great day, Nadia Erin: Vitamin c help!! Ok so i was told only to take food based vitamin c but all the other is synthetic and depletes copper....so can you please clear this up for me. I really appreciate it!! Ryan: Hello! I have seen recently a somewhat controversial opinion on D3 supplementation and would like your opinion. Usually, I'd gloss over something like this, but considering the high reputation of the source in the functional/integrative space, I thought I'd get your highly valued opinion. Quote… "D3 is not what they measure in a vitamin D test. They measure 25D. The problem is, they should be measuring 1,25D, and better yet, the ratio between the two. Supplementing D3 will raise your 25D levels which shuts down your vitamin D receptors and innate immune system function. Supplementing D3 above what we naturally get in food will massively increase calcium absorption. In a hard-drinking water world, that causes hypercalcemia, magnesium and K2 deficiency.” Jamie: Hi Dr Cabral thank you for all you do. I have been listening for a very long time. I'll try to keep this short as I did try to search if you have talked about this before but couldn't find anything. I currently see a Dr who claims to be an integrative doctor local to me. I'm 33 year old female. I weigh around 130#. My symptoms have been thinning hair, nail fungus, zero libido, zero energy and pms 2 weeks prior to menstruating, (this has been for many years) increase of stress the past two years due to my job. . He did lab work and my thyroid levels are low, and vitamin d was low. He also told me that I should take Progesterone 100mg qhs for the pms symptoms / low energy. Long story short I'm taking t3/t4 15mcg daily (along with fish oil, vitamin d, b complex, magnesium from EquiLife) I had more lab work done recently and my IGF-1 is 208 (says it should be 280) and he is recommending Sermorelin therapy. I googled it and it sounds fantastic. All the things I need (energy, libido etc) but my question is being only 33 (no kids) is going to harm me in the long run taking these hormones? I know you can't tell me to stop, I just need advice on really what this Sermorelin therapy is and if it is going to hurt me in the long run taking progesterone “forever”. Thank you Leah: Big thanks to you and the team for all the information you put out! If you must get the vaccine, and it is not your preference to do so, can you detox from it? And if so, how? Thanks! Andrea: My 9 year old daughter started menstruating this month. She is already taking a daily multivitamin, what other supplement would you advise her growing body would need to better support her during this stage? Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes & Resources:  http://StephenCabral.com/2123 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -  Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Stress, Sleep & Hormones Test (Run your adrenal & hormone levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels)

Ross Trudeau steps up to the plate, swings, and it's a hit -- because Ross Trudeaus' crosswords are always a hit. This is a more high-brow crossword than is typical for the New York Times, as there were 3 clues that tied in to 28D, Literary trio found in the answers to this puzzle's starred clues, THEBRONTES. Those clues -- 6D, Chain known for its soft pretzels, AUNTIEANNES; 25D, Prominent left-leaning political action committee, EMILYSLIST;  and the rather lengthy 19A, Children's book whose title character says, "If I can fool a bug, I can surely fool a man. People are not as smart as bugs", CHARLOTTESWEB; all contained the name of one of THEBRONTES. Outstanding!In other news, it's Triplet Tuesday, and Jean makes it look easy. To hear the blow-by-blow, download and listen up.

It's a Robyn Weintraub Friday puzzle, and that means tough, fair, and  LOL clues all over the grid. To get things rolling, take a look at 25D, Big wheel at a party?, BRIE. She also ought to win an award for 17A, Olympics haul of fame?, GOLDMEDALS, which was just fractionally better than 44D, Irrational thing to celebrate? PIDAY. There's much more in the grid and on the podcast -- which also includes a Fun Fact Friday segment on Olympic diving -- so be sure and download and listen up!

We've had Dr. Peat on the podcast before, and it actually ended up being our most downloaded WinAtLife podcast. So, we brought him back again to discuss vitamin D, calcium and mineral metabolism. There's so much good information in this one! Dr. Peat offers up a lot of clarity when it comes to the great vitamin D debate. So, should you supplement vitamin D? Should you not? What else should you know when it comes to vitamin D and your metabolic health? As a reminder Vitamin D has many namesThe three most mentioned in this podcast areCholecalciferol also known as D3 (what is in food or supplements)"Stored D" also know as calcidiol / 25OHD /hydroxycholecalciferol"Active D" also know as calcitriol / 1,25DDr. Peat uses the references of 25OHD /hydroxycholecalciferol (stored) and 1,25D (active)In this episode we talk about...➡️ The purpose of Vitamin D➡️ How is vitamin D metabolised and stored➡️ How much D is too much? ➡️ The difference between Active and Stored Vitamin D➡️ Can "stored D" have active properties?➡️ Is elevated Active D (1,25D) a good thing?➡️ Do Vitamin D supplements suppress the immune system?➡️ The Vitamin D "receptor" theory-is it correct?➡️ Are blood levels of stored D (25OHD) correct?➡️ What are optimal stored Vitamin D levels?➡️ The relationship between D and Ca➡️ Understanding the importance of parathyroid hormone (PTH)➡️ What can affect PTH besides Calcium and Vitamin D➡️ What causes calcified tissue➡️ Understanding the calcium -magnesium connection➡️ What ratios, if any, are optimal for minerals?➡️ Understanding Hair Tissue Mineral Analysis? Are they accurate?Check out the entire podcast episode on Apple Podcasts, Spotify, Google Podcast, Stitcher, and iHeart Radio by searching for The Winatlife Podcast.At the end of the podcast, Ray was asked about a study involving Vitamin D supplements and Bone density.Here is the study and his answer:Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone StrengthA Randomized Clinical Trial. https://jamanetwork.com/journals/jama/fullarticle/2748796--i"They didn't control their phosphate intake, so it's possible that the high dose D was now and then increasing the 1,25-dihydroxy D, taking some calcium out of the bone. A problem with judging bone mineral content with x-rays is that, in stress, the fat in bone is reduced, and replaced by water, causing more of the x-rays to be absorbed, making the bone seem denser.   High-dose vitamin D without extra calcium supplementation has been associated with increased levels of the active vitamin D metabolite 1, 25(OH)2 vitamin D (calcitriol), and an increase in CTx."Buy Kates book: https://nustrength.myshopify.com/products/how-to-heal-your-metabolism-by-kate-deeringDiscount code: KATE10Follow Kitty on Instagram: @kittyblomfieldFollow Kate on Instagram: @katedeeringfitness

It's a gigantic crossword! No, not really, it is just 15x15, but it did manage to fit a giant's trademark FEEFIFOFUM into the answers. It also slipped in one of our favorite shows, 25D, Discovery Channel program that debunked popular beliefs, MYTHBUSTERS, and therefore EARN our respect. We were glad to see a shoutout to 26A, Island nation in the western Pacific, PALAU, as well as one of our all-time favorite deities, 49D, Greek goddess of wisdom, ATHENA. A nice crossword - Ross Trudeau is inherently incapable of writing any other kind - we give it a 5 squares on the JAMCR scale.

The EPITOME of what a Monday crossword should be -- not too difficult, with a GLOB of humor (6D, Try, try again?, REHEAR, and 25D, Shelters for shelties, KENNELS), and a few novel words (41D, Theatergoer's break, ENTRACTE, and the slightly more common but even more difficult to spell word, 67A, Garlicky sauce, AIOLI). Jean was able to get through all of this with her usual APLOMB, while Mike wasn't quite as TIMELY. We give it a 5 squares on the JAMCR scale.

A solid Saturday by veteran crossword constructor John Guzzetta, with a particularly knotty nattick at the junction of 25D, Is lachrymose, and 40A, "Young Man With a Skull" painter. The answers were WEEPS and HALS, although for those unfamiliar with the artist and wobbly when it comes to grammar, WEEPY and HALY are perfectly understandable. As your registered gramma might've said, gramma(r) matters.Listen on to hear all the details, and as always, we love to get feedback -- crosswordpodcast@icloud.com

If you didn't get today's crossword, well, HAKUNA MATATA, NOLOSS. It was a Saturday, ERGO it was bound to be a bit of an OGRE.Some particularly memorable clues -- 54D, An expert on feet, POET, 9A, 1, 2, 3, 4, ..., 11, 12, 14, etc., FLOORS, and, oh ANOTHERONE, 25D, 28 pound debut of 1981, IBMPC. We give it a 4.5 squares on the increasingly precise JAMCR scale. Remember, if you want to get in touch to provide feedback on anything you hear here, just email us at crosswordpodcast@icloud.com.

Samma dag var två lärjungar på väg till en by som ligger en mil från Jerusalem och som heter Emmaus. 14De talade med varandra om allt det som hade hänt. 15Medan de gick där och samtalade och diskuterade kom Jesus själv och slog följe med dem. 16Men deras ögon var förblindade och de kände inte igen honom. 17Han frågade: ”Vad är det ni går här och talar med varandra om?” De stannade och såg sorgsna ut, 18och den ene, som hette Kleopas, svarade: ”Du måste vara den ende som har varit i Jerusalem och inte vet vad som har hänt där under dessa dagar.” – 19”Vad har hänt?” frågade han. De svarade: ”Detta med Jesus från Nasaret, han som var en profet, mäktig i ord och gärning inför Gud och hela folket. 20Han blev utlämnad av våra överstepräster och rådsherrar, och de fick honom dömd till döden och korsfäst, 21medan vi hoppades att han var den som skall befria Israel. Men till allt detta kommer att det är tredje dagen sedan det här hände, 22och nu har några kvinnor bland oss gjort oss uppskakade. De var vid graven tidigt i morse 23men fann inte hans kropp, och då kom de tillbaka och berättade att de i en syn hade sett änglar som sade att han lever. 24Några av de våra gick ut till graven, och de fann att det var så som kvinnorna hade sagt. Honom själv såg de inte.” 25Då sade han: ”Förstår ni så lite, är ni så tröga till att tro på det som profeterna har sagt? 26Skulle inte Messias lida detta och gå in i sin härlighet?” 27Och med början hos Mose och alla profeterna förklarade han för dem vad som står om honom överallt i skrifterna.28De var nästan framme vid byn dit de skulle, och han såg ut att vilja gå vidare, 29men de höll kvar honom och sade: ”Stanna hos oss. Det börjar bli kväll och dagen är snart slut.” Då följde han med in och stannade hos dem. 30När han sedan låg till bords med dem tog han brödet, läste tackbönen, bröt det och gav åt dem. 31Då öppnades deras ögon och de kände igen honom, men han försvann ur deras åsyn. 32Och de sade till varandra: ”Brann inte våra hjärtan när han talade till oss på vägen och utlade skrifterna för oss?”33De bröt genast upp och återvände till Jerusalem, där de fann de elva och alla de andra församlade, 34och dessa sade: ”Herren har verkligen blivit uppväckt och han har visat sig för Simon.” 35Själva berättade de då vad som hade hänt dem på vägen och hur han hade gett sig till känna för dem genom att bryta brödet.Luk 24:13-35 (Bibel 2000)Marie Ek Lipanovskahttp://www.marieeklipanovska.seMusic: www.bensound.com

De höll ögonen på honom och skickade fram några som skulle spela rättfärdiga och söka få fast honom för något yttrande, så att de kunde överlämna honom åt ståthållarens makt och myndighet. 21De frågade honom: ”Mästare, vi vet att vad du säger i din undervisning är riktigt och att du inte tar hänsyn till person utan verkligen lär oss Guds väg. 22Är det rätt eller inte att vi betalar skatt till kejsaren?” 23Men han genomskådade deras list och sade: 24”Visa mig en denar. Vems bild och namn finns på den?” – ”Kejsarens”, svarade de. 25Då sade han: ”Ge då kejsaren det som tillhör kejsaren och Gud det som tillhör Gud.” 26De lyckades inte få fast honom för något som han sade när folket hörde på, och de häpnade över hans svar och teg.Luk 20:20-26 (Bibel 2000) Marie Ek Lipanovskahttp://www.marieeklipanovska.se

Sedan kom de att tvista om vilken av dem som skulle anses vara den störste. 25Då sade han till dem: ”Kungarna uppträder som herrar över sina folk, och de som har makten låter kalla sig folkets välgörare. 26Men med er är det annorlunda: den störste bland er skall vara som den yngste, och den som är ledare skall vara som tjänaren. 27Vem är störst, den som ligger till bords eller den som betjänar honom? Är det inte den som ligger till bords? Men jag är mitt ibland er som er tjänare. Luk 22:24-27 (Bibel 2000)Marie Ek Lipanovskahttp://www.marieeklipanovska.se

När grödan bärgas i ert land, skall du inte skörda ända ut till åkerrenen, inte heller skall du samla in de sista axen av skörden. Du skall lämna kvar det åt den fattige och åt invandraren. Jag är Herren, er Gud.23Herren talade till Mose:24Säg till israeliterna: I sjunde månaden, på första dagen i månaden, skall det vara sabbatsvila, en minnesdag då ni stöter i horn och håller en helig sammankomst. 25Då får ni inte utföra några sysslor, ni skall offra eldoffer åt Herren.26Herren talade till Mose:27På tionde dagen i samma månad, den sjunde, infaller försoningsdagen. Då skall ni hålla en helig sammankomst, späka er och offra eldoffer åt Herren. 28Något arbete får ni inte utföra på den dagen, ty det är en försoningsdag som skall bringa försoning åt er inför Herren, er Gud. 29Var och en som inte späker sig på den dagen skall utstötas ur sitt folk. 30Och var och en som utför arbete på den dagen skall jag utrensa ur hans folk. 31Ni får inte utföra något arbete. Detta skall vara en oföränderlig stadga för er genom alla släktled, var ni än bor. 32Det skall vara en vilodag för er, en sabbat då ni skall späka er. Från kvällen den nionde dagen i månaden till nästa kväll skall ni hålla denna sabbat.33Herren talade till Mose:34Säg till israeliterna: På femtonde dagen i samma månad, den sjunde, infaller Herrens lövhyddefest, som varar i en vecka. 35Den första dagen är det en helig sammankomst, då får ni inte utföra några sysslor. 36Under sju dagar skall ni offra eldoffer åt Herren, och på den åttonde dagen skall ni hålla en helig sammankomst och offra eldoffer åt Herren. Då är det en högtidssamling, och ni får inte utföra några sysslor.3 Mos 23:22-36 (Bibel 2000)Marie Ek Lipanovskahttp://www.marieeklipanovska.se

Volatility Review: A look back at the week from a volatility perspective This week, featuring guest co-host Bill Valentine from Valentine Ventures. The old VIX call vs SPX put debate continues VIX Cash - 12.5, up 0.3 from last show RVX - 14.6, up 0.7 from last week VVIX - 89, 2 handles higher than last show Size "hedge" in SPX puts this week VIX Options - ADV, 452K, VIX call/put: 2.8/1, Total 7.77m (5.74m Calls, 2.03m Puts) VXX - 26.65, almost unchanged from last show Volatility Voicemail: Volatility Flash Poll The CBOE Skew Index alarmed many when it soared above 150. Of course, every index tells its own skew story. Which index do you think has the steepest skew right now (aka 25D put vol vs. 25D Call vol)? Russell 2000 S&P 500 Nasdaq Other Listener questions and comments: Question from Leans - Do you think SVXY will ever go back to its pre-Feb structure? Question from Tim - Is there really such a thing as a "covered call" in VIX since the options don't expire into futures? If I'm long a future and sell a XIV call against it what is that called? Crystal Ball: Your prognostication headquarters Last week: Mark L. - 11.25 Mark S. - 12.14 This week: Mark L. - 11.75 Mark S. - 12.15 Bill - 13.00

Trading Block: The Trump trade deal: Bringing Canada and Mexico back to the table. The Tesla investigation was a farce: seems like the SEC just wanted some headlines. Odd Block: A summary of Tesla (TSLA) puts, options palooza in New Age Beverages Corp (NBEV), put love & call stupid in WisdomTree TR/Japan Hedged Equity (DXJ) and opening put palooza in AVEO Pharmaceuticals (AVEO) Strategy Block: Uncle Mike Tosaw discusses investing 101. Mail Block: Volatility Flash Poll The CBOE Skew Index alarmed many when it soared above 150. Of course, every index tells its own skew story. Which index do you think has the steepest skew right now (aka 25D put vol vs. 25D Call vol)? 41% - Russell 2000 26% - S&P 500 30% - Nasdaq 3% - Other Listner questions and comments: Question from Oytrate - What is a reason that someone would write ITM covered calls? Seems like a waste of time to me since you're capping all of your upside. Comment from J3dingle - Thanks Mark, I really enjoyed that segment. There was so much going on at that time, I actually forgot all about the short selling ban. I remember seeing Morgan Stanley at sub-$10. Bear Stearns bought for $2, then up-ed to $10. Citi trading for less than a $1? (Pre-reverse split) Question from UpwardMomentum - Approximately what percentage of your unusual option activity trades are winners? Around the Block/This Week in the Markets: Oct 1 - Construction Spending Oct 4 - Jobless Claims, Factory Orders Oct 5 - Unemployment, Consumer Credit

Trading Block: The Trump trade deal: Bringing Canada and Mexico back to the table. The Tesla investigation was a farce: seems like the SEC just wanted some headlines. Odd Block: A summary of Tesla (TSLA) puts, options palooza in New Age Beverages Corp (NBEV), put love & call stupid in WisdomTree TR/Japan Hedged Equity (DXJ) and opening put palooza in AVEO Pharmaceuticals (AVEO) Strategy Block: Uncle Mike Tosaw discusses investing 101. Mail Block: Volatility Flash Poll The CBOE Skew Index alarmed many when it soared above 150. Of course, every index tells its own skew story. Which index do you think has the steepest skew right now (aka 25D put vol vs. 25D Call vol)? 41% - Russell 2000 26% - S&P 500 30% - Nasdaq 3% - Other Listner questions and comments: Question from Oytrate - What is a reason that someone would write ITM covered calls? Seems like a waste of time to me since you're capping all of your upside. Comment from J3dingle - Thanks Mark, I really enjoyed that segment. There was so much going on at that time, I actually forgot all about the short selling ban. I remember seeing Morgan Stanley at sub-$10. Bear Stearns bought for $2, then up-ed to $10. Citi trading for less than a $1? (Pre-reverse split) Question from UpwardMomentum - Approximately what percentage of your unusual option activity trades are winners? Around the Block/This Week in the Markets: Oct 1 - Construction Spending Oct 4 - Jobless Claims, Factory Orders Oct 5 - Unemployment, Consumer Credit

Volatility Review: A look back at the week from a volatility perspective This week, featuring guest co-host Bill Valentine from Valentine Ventures. The old VIX call vs SPX put debate continues VIX Cash - 12.5, up 0.3 from last show RVX - 14.6, up 0.7 from last week VVIX - 89, 2 handles higher than last show Size "hedge" in SPX puts this week VIX Options - ADV, 452K, VIX call/put: 2.8/1, Total 7.77m (5.74m Calls, 2.03m Puts) VXX - 26.65, almost unchanged from last show Volatility Voicemail: Volatility Flash Poll The CBOE Skew Index alarmed many when it soared above 150. Of course, every index tells its own skew story. Which index do you think has the steepest skew right now (aka 25D put vol vs. 25D Call vol)? Russell 2000 S&P 500 Nasdaq Other Listener questions and comments: Question from Leans - Do you think SVXY will ever go back to its pre-Feb structure? Question from Tim - Is there really such a thing as a "covered call" in VIX since the options don't expire into futures? If I'm long a future and sell a XIV call against it what is that called? Crystal Ball: Your prognostication headquarters Last week: Mark L. - 11.25 Mark S. - 12.14 This week: Mark L. - 11.75 Mark S. - 12.15 Bill - 13.00

Trading Block: Earnings! Disney Blackberry Plus, Google searches for hedges are ticking up. Odd Block: Puts trade in Bed Bath & Beyond Inc. (BBBY), call love in Ally Financial Inc. (ALLY) and call love in Virtu Financial Inc. (VIRT). Mail Block: Volatility Flash Poll The CBOE Skew Index alarmed many when it soared above 150. Of course, every index tells its own skew story. Which index do you think has the steepest skew right now (aka 25D put vol vs. 25D Call vol)? Russell 2000 S&P 500 Nasdaq Other Around the Block/This Week in the Markets Sep 28: Personal Income, Consumer Sentiment

Trading Block: Earnings! Disney Blackberry Plus, Google searches for hedges are ticking up. Odd Block: Puts trade in Bed Bath & Beyond Inc. (BBBY), call love in Ally Financial Inc. (ALLY) and call love in Virtu Financial Inc. (VIRT). Mail Block: Volatility Flash Poll The CBOE Skew Index alarmed many when it soared above 150. Of course, every index tells its own skew story. Which index do you think has the steepest skew right now (aka 25D put vol vs. 25D Call vol)? Russell 2000 S&P 500 Nasdaq Other Around the Block/This Week in the Markets Sep 28: Personal Income, Consumer Sentiment

Topics this week include: Crude Equities/Russell Metals/Gold Ags/Soybeans Futures Options Feedback: Listeners weigh in Comment from L Sert - Missed Nick on the show. What's his thought on the big $150 crude prediction? Question from P Kell - Looking at CME TWIFO page and trying to figure it out. What do the numbers in the 25D and 25D QuikSkew columns mean? Apologize if you've answered this before but just discovered the show.

Topics this week include: Crude Equities/Russell Metals/Gold Ags/Soybeans Futures Options Feedback: Listeners weigh in Comment from L Sert - Missed Nick on the show. What's his thought on the big $150 crude prediction? Question from P Kell - Looking at CME TWIFO page and trying to figure it out. What do the numbers in the 25D and 25D QuikSkew columns mean? Apologize if you've answered this before but just discovered the show.

There was once a game called Advent Rising. It was hyped up as the next great science-fiction adventure that would transcend games and become something more. Unfortunately, it released in 2005 with a multitude of bugs in an era where patching post-release was a rarity at best. Advent Rising caused the implosion of its development studio, GlyphX Games. A group of individual developers escaped the studio's downfall, banding together to form Chair Entertainment. The newly minted indie studio went on to develop and release Shadow Complex in 2009.  The 2.5D metroidvania side-scroller adopted a more realistic aesthetic and spawned a series of novels authored by Orson Scott Card. The game released and seemed to fill a niche in the indie gaming world that hadn't been filled in quite that same way before. With a recent remaster, it seems like a perfect time to ask the question: Is Shadow Complex one of the best games period? Outro music: Tales of Phantasia 'The Koan of Drums' by djpretzel (http://ocremix.org/remix/OCR01500) You can follow the show on Twitter: @BestGamesPeriod Or download the podcast from Soundcloud: https://soundcloud.com/thebestgamesperiod Support us on Patreon! - https://www.patreon.com/bestgamesperiod

Martin Valman förkunnar utifrån evangelietexten ur Markusevangeliet 5:24-34: 24Och Jesus gick med honom. Mycket folk följde efter och trängde sig inpå honom. 25Där fanns en kvinna som hade lidit av blödningar i tolv år. 26Hon hade varit hos många läkare och fått utstå mycket. Det hade kostat henne allt hon ägde, men ingenting hade hjälpt, snarare hade hon blivit sämre. 27Hon hade hört vad som berättades om Jesus, och nu kom hon bakifrån i hopen och rörde vid hans mantel, 28för hon tänkte att om hon bara fick röra vid hans kläder skulle hon bli hjälpt. 29Och genast stannade blodflödet, och hon kände i kroppen att hon var botad från sitt onda. 30När Jesus märkte att det hade gått ut kraft från honom vände han sig om i hopen och frågade: ”Vem rörde vid mina kläder?” 31Lärjungarna sade: ”Du ser väl hur folk tränger på, och ändå frågar du vem som har rört vid dig!” 32Han såg sig omkring efter henne som hade gjort det. 33Kvinnan, som visste vad som hade hänt med henne, kom rädd och darrande fram och föll ner för honom och talade om hur det var. 34Han sade till henne: ”Min dotter, din tro har hjälpt dig. Gå i frid. Du är botad från ditt onda.”

Vitamin D kann entweder durch die Nahrung aufgenommen oder durch UV- Bestrahlung der Haut aus 7-Dehydrocholesterol gebildet werden. Das entstehende inaktive Vitamin D3 wird anschließend durch die 25-Hydroxylase (CYP2R1) in der Leber zu 25-Hydroxyvitamin D3 (25D) metabolisiert. 25D ist die vornehmlich zirkulierende Form von Vitamin D, es selbst besitzt allerdings nur etwa ein Tausendstel der Aktivität der endgültigen, aktiven Form des Hormons, 1α,25- Hydroxyvitamin D3 (1,25D), das überwiegend in der Niere durch die mitochondriale Hydroxylase CYP27B1 produziert und im Plasma durch Interaktion mit DBP (plasma vitamin D binding protein) stabilisiert und transportiert wird. Die Hauptfunktion von 1,25D besteht offenbar in der Bindung an das intrazelluläre Protein Vitamin D Rezeptor (VDR), welches daraufhin typischerweise mit einem zweiten Protein, dem Retinoid X Rezeptor, heterodimersisiert und dann gemeinsam mit diesem an sogenannte Vitamin D response elements (VDREs) in der DNA bindet. Die weiteren Konsequenzen dieser Bindung sind nicht in allen Einzelheiten verstanden, führen aber entweder zur transkriptionellen Aktivierung oder Reprimierung einer großen Anzahl von Gensequenzen. Die E3 Ubiquitin-Ligase und Transkriptionsrepressor MDM2 ist ein potenter Inhibitor der p53 Familie von Transkriptionsfaktoren, Stoffwechselregulatoren und Tumorsuppressoren. Es konnte mit dieser Arbeit gezeigt werden, dass der VDR ein weiterer Transkriptionsfaktor, Stoffwechselregulator und Tumorsuppressor ist, welcher ebenfalls von MDM2 gebunden und inhibiert wird. Es stellte sich heraus, dass der VDR in der Zelle zum Teil durch MDM2 ubiquityliert wird, seine Steady-State Level durch das Proteasom kontrolliert werden und ein Knockdown von endogenem MDM2 die VDR-Level erhöht. Ein Knockdown von MDM2 führte zu einer signifikanten Erhöhung des Transkripts der Gene CYP24A1 und p21, klassische zelluläre Ziele der Transaktivierung durch ligandengebundenen VDR. Die Ergebnisse dieser Arbeit legen nahe, dass MDM2 analog zu p53 den VDR negativ reguliert.