Podcasts about carriers

On this abbreviated show, Lance talks with FC Cincy's Nick Hagglund about the club's playoff victory over Columbus, and comments on Reds and Bengals topics.

On this abbreviated show, Lance talks with FC Cincy's Nick Hagglund about the club's playoff victory over Columbus, and comments on Reds and Bengals topics.See omnystudio.com/listener for privacy information.

Recorded live at the SaaS Summit in Amsterdam, this episode of the Grow Your B2B SaaS Podcast dives into a focused conversation with Mark Appel, Chief Marketing Officer at Sendcloud. As one of Europe's fastest-growing B2B SaaS platforms, Sendcloud operates across eight European markets, generating close to 60 million in annual recurring revenue with a team of about 450. In this discussion, Mark reveals how Sendcloud approaches international scaling, builds cross-functional go-to-market alignment, identifies and prioritizes compounding growth loops, and integrates AI agents across marketing and GTM operations. He also reflects on what he would do differently if he could rebuild a SaaS go-to-market motion from scratch, what early-stage founders should focus on to reach their first 10K MRR, and how to evolve from feature-led messaging to a brand-led narrative on the path to 10 million ARR.Key Timecodes(00:00) – Intro: Scaling B2B SaaS, Growth Loops & AI GTM 2026(01:10) – Guest Intro: Mark Appel, CMO of Sendcloud(01:39) – Company Snapshot: €60M ARR, 450 Employees, 8 Markets(02:20) – 2026 Focus: International SaaS Scaling Strategy(02:36) – Cross-Functional GTM: Marketing, Sales & CS Alignment(03:26) – GTM Motion: Hybrid PLG + SLG in B2B SaaS(03:39) – Finding Growth Loops Across 8 Countries(04:34) – Working Growth Loops: Demand to Revenue Flywheel(05:15) – Platform Network Effects: Merchants, Carriers & Partners(06:13) – Built-in Virality: Tracking Emails as Growth Channel(06:51) – Ad Break: Reditus Affiliate & Referral Growth(07:35) – AI for GTM 2026: AI SDRs & Marketing Agents(08:50) – AI Implementation: Challenges & Early Adoption(09:55) – Biggest GTM Shift: Retention, Expansion & Automation(10:22) – PLG in Product: Driving Adoption via In-App Prompts(11:40) – Rebuilding GTM: Cross-Functional Pods by Segment(12:41) – Segmentation: Startup to Enterprise Strategy(13:21) – Future Growth Loops: Consumer Visibility for SaaS(14:41) – 0 to 10K MRR: In-Market Demand & Search Campaigns(15:34) – 10K MRR to €10M ARR: Brand-Led SaaS Growth(16:03) – Connect with Mark Appel: LinkedIn & Email(16:18) – Outro & CTA: Subscribe, Sponsor & Learn via Reditus

“The tide is turning, but it hasn't gone out yet.” — Alex Quilici, CEO, YouMail In this Technology Reseller News podcast, Doug Green speaks with Alex Quilici, CEO of YouMail, about how the company is helping both carriers and enterprises identify, block, and eliminate fraudulent robocalls and impersonation attacks. After peaking at nearly 5 billion robocalls per month, U.S. volumes have fallen by more than a billion calls—a positive trend, though the fraudsters behind the remaining calls are earning more money with fewer calls. Quilici explains that YouMail, a Cloud Communications Alliance (CCA) member, is helping stop telecom “troublemakers” through a suite of AI-driven solutions that protect consumers, carriers, and enterprises alike. For carriers, YouMail's Watch and Score products flag risky robocallers by monitoring live calling behavior. Carriers upload the phone numbers they issue, and YouMail reports back when any number engages in suspicious or illegal activity—empowering providers to act quickly and shut bad actors off the network. For enterprises, YouMail's Quash solution identifies and suppresses impersonation campaigns in real time. Using analytics and carrier collaboration, Quash helps organizations such as banks and hospitality brands detect where fraudulent calls originate, block offenders, and even prepare evidence packages for law enforcement. Case studies on Regions Bank and Marriott highlight real-world success: a 60 percent reduction in telecom attacks and an $8 million fraud judgment. The results demonstrate how YouMail's technology helps legitimate businesses reclaim trust in their communications. Looking ahead to 2026, YouMail is developing a referral and reseller program to extend its protection ecosystem to more carriers and call-center partners. Learn more at youmail.com.

1 John 4:4 NIV"You, dear children, are from God and have overcome them, because the one who is in you is greater than the one who is in the world."

1 John 4:4 NIV"You, dear children, are from God and have overcome them, because the one who is in you is greater than the one who is in the world."

1 John 4:4 NIV"You, dear children, are from God and have overcome them, because the one who is in you is greater than the one who is in the world."

This special episode of the Native Language Protectors and Carriers series features Freddie Lewis, a dedicated Choctaw language instructor at the University of Oklahoma. Dr. Farina King talks with Freddie about the challenges and joys of sustaining Indigenous languages such as Choctaw. Freddie shares personal stories about his family's experiences with boarding schools, the power of community-led language revitalization, and how teaching connects generations. The conversation highlights the rich legacy of the Choctaw Code Talkers, the significance of cultural memory, and exciting new projects bringing the Choctaw language to young learners and mass media.Freddie Lewis is recognized by the Choctaw Nation as a certified language teacher and has over 12 years of experience teaching multiple levels of Choctaw at the University of Oklahoma (OU). In addition to his university work, he leads community classes, collaborates with museums, and involves his students in projects that support language learning and cultural preservation.Listeners are especially encouraged to check out the powerful new short documentary (about 14 minutes long) Voices of Valor, which honors the Choctaw Code Talkers and shines a light on their enduring impact. The film will be screening at the Native Nations Center event room on the OU Norman campus on November 11, 2025, starting at 9 am Central Time.Resources:"Voices of Valor Film Debut," The Middle Ground"Native American Languages at OU"Choctaw Language Classes, Choctaw Nation of OklahomaChoctaw Cultural CenterFirst Americans MuseumClassroom VR Trunks: Choctaw Code Talkers 1918Marvel ECHO x Choctaw Nation"‘Sinners' Puts ‘Truth on Screen' for the Mississippi Band Of Choctaw Indians," AP June 6, 2025.Learn more about the efforts to protect and support the study of Native American languages (and all languages) at the University of Oklahoma through the following petitions:Oppose the Removal of Foreign Language Gen Ed requirements at the University of OklahomaKeep Indigenous Languages Alive at OUFor more information about the Oklahoma Native American Youth Language Fair, see the hyperlink.

Lance takes your calls on a variety of reds off-season topics, including free agency and more roster decisions.

Lance takes your calls on a variety of reds off-season topics, including free agency and more roster decisions.See omnystudio.com/listener for privacy information.

Dave Patterson at Ministers Fellowship International Global Leadership Conference 2025.Ministers Fellowship International exists to help leaders build healthy, strong, impacting churches and to do so in a way that makes for a healthy leader. We hope that this teaching left you more encouraged and equipped today.We hope that this teaching left you more encouraged and equipped today. Ministers Fellowship International exists to help leaders build healthy, strong, impacting churches and to do so in a way that makes for a healthy leader.

Send us a textBulk Carriers: The Hidden Work Horses of The SeaIn this episode of Sea Views, hosts Julia Gosling and Adam Parnell speak with Matt Shirley (CEO, Safe Harbours Australia) and Marco Blanco (CFO, Safe Harbours Australia) - veteran maritime pilots leading a consultancy that's reshaping the standards of bridge team management and port safety worldwide.What we cover:Why bulk carriers are the “workhorses of the sea” and how Australia became their global hubHow Safe Harbours Australia trains bridge teams for high-stakes decision-makingWhat the Ships of Shame era taught the world about maritime accountabilityHow communication and leadership directly impact safety cultureWhy treating crews as assets and not commodities drives operational excellenceAbout Safe Harbours AustraliaWith over 140 years of combined commercial shipping experience and 70 years as qualified marine pilots, Safe Harbours Australia delivers independent consultancy, peer reviews, operational assessments, and advanced Bridge Team Management Training. Their expertise covers pilotage safety systems, simulator facilitation, incident investigation, and autonomous shipping design.

How do Australian maritime experts redefine safety, leadership, and communication in one of the world's toughest shipping arenas? In this episode of Sea Views, hosts Julia Gosling and Adam Parnell speak with Matt Shirley (CEO, Safe Harbours Australia) and Marco Blanco (CFO, Safe Harbours Australia) — veteran maritime pilots leading a consultancy that's reshaping the standards of bridge team management and port safety worldwide. ⚓ What You'll Learn: Why bulk carriers are the “workhorses of the sea” and how Australia became their global hub How Safe Harbours Australia trains bridge teams for high-stakes decision-making What the Ships of Shame era taught the world about maritime accountability How communication and leadership directly impact safety culture The future of maritime safety amid AI, automation, and decarbonization Why treating crews as assets — not commodities — drives operational excellence

Lance hosts Xavier men's basketball coach Richard Pitino, Richard Skinner of Local 12 joins to talk Bengals, and Lance takes your calls on a variety of topics.

Lance hosts Xavier men's basketball coach Richard Pitino, Richard Skinner of Local 12 joins to talk Bengals, and Lance takes your calls on a variety of topics.See omnystudio.com/listener for privacy information.

Lance hosts Xavier men's basketball coach Richard Pitino, Richard Skinner of Local 12 joins to talk Bengals, and Lance takes your calls on a variety of topics.

RNT_ Carriers, Courts, Canada, Coffee, and Trump

Lance talks with FC CIncinnati play-by-play man Tommy Gelehrter about the club's 1-0 playoff win over Columbus, reacts to the Bengals' shocking loss to the Jets, and more.See omnystudio.com/listener for privacy information.

Lance talks with FC CIncinnati play-by-play man Tommy Gelehrter about the club's 1-0 playoff win over Columbus, reacts to the Bengals' shocking loss to the Jets, and more.

Lance talks with FC CIncinnati play-by-play man Tommy Gelehrter about the club's 1-0 playoff win over Columbus, reacts to the Bengals' shocking loss to the Jets, and more.

President Trump brokers monumental deals in Asia, the U.S. ramps up its military presence in the Caribbean, and we get an expert opinion on the state of the Trump economy. Get the facts first with Morning Wire. - - - Wake up with new Morning Wire merch: https://bit.ly/4lIubt3 - - - Today's Sponsors: Boll & Branch - Get 20% off Bed Bundles at https://BollAndBranch.com/WIRE SelectQuote - Save more than 50% on term life insurance at https://SelectQuote.com/morning - - - Privacy Policy: https://www.dailywire.com/privacy morning wire,morning wire podcast,the morning wire podcast,Georgia Howe,John Bickley,daily wire podcast,podcast,news podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

Lance is starting this weekend early, so Mo Egger is stepping in! Robert Weintraub stops by to weigh in on Joe Flacco and the Bengals. Plus, Danny Kanell gives the latest on betting lines and more. Tune in to win!

The John Kobylt Show Hour 3 (10/23) - Tim Conway Jr. fills in for John. Caleb Lindsey, Director of Operations for R+L Carriers SoCal, highlighted the company's impressive new Bloomington Service Center, one of 13 California hubs. The state-of-the-art terminal features 325 dock doors and a 350% increase in door capacity over the previous location, plus a multi-bay maintenance shop—a major boost to the company's Southern California freight operations. Crime continues to surge in Arcadia, where a jewelry store heist saw burglars tunnel through a wall to loot valuables, followed by a home invasion where armed intruders tied up victims, stealing both jewelry and a car. In West Hollywood, a Rolex thief picked the wrong target—his victim turned out to be a professional fighter, who tackled and subdued him on the spot. The NBA gambling scandal deepened as U.S. Attorney Joseph Nocella Jr. condemned the alleged mob-linked insider betting ring involving Rozier and Jones, calling it “one of the most brazen sports corruption schemes since the legalization of online betting.” Officials say the operation manipulated confidential NBA player information to rig wagers and rake in millions. Angel checked in with Thursday's traffic hotspots, while national headlines included a massive egg recall—over 6 million eggs pulled due to Salmonella risk—and methane gas leak evacuations on the Balboa Peninsula in Newport Beach. Rounding out the hour, Toys “R” Us announced a nostalgic comeback with 30 new stores opening nationwide just in time for the holidays. 

Lance is joined by Charlie Goldsmith and Scott Springer to discuss Cincinnati sports, plus he tracks the Machine, talks Bengals and takes your calls.

Lance is joined by Charlie Goldsmith and Scott Springer to discuss Cincinnati sports, plus he tracks the Machine, talks Bengals and takes your calls.See omnystudio.com/listener for privacy information.

Lance is joined by Charlie Goldsmith and Scott Springer to discuss Cincinnati sports, plus he tracks the Machine, talks Bengals and takes your calls.

Lance talks with FC Cincinnati GM Chris Albright and DB Matthew McDoom of UC Football, plus he dives into Reds and Bengals topics and takes your calls.

This Day in Maine for Wednesday, October 22, 2025.

Lance talks with FC Cincinnati GM Chris Albright and DB Matthew McDoom of UC Football, plus he dives into Reds and Bengals topics and takes your calls.

Tepid demand, weak rates and rising costs are just some of the challenges facing the North American truckload market. Carriers and drivers also face subpar infrastructure, rising fraud and stricter emission standards. In this Talking Transports podcast, Jim Ward, president of the Truckload Carriers Association, joins Lee Klaskow, Bloomberg Intelligence’s senior transportation and logistics analyst, to discuss how the trade group is working to ease these burdens. They also discuss how Trump administration actions affect non-domiciled commercial driver licenses and English proficiency enforcement. Ward touches on electric and autonomous vehicles, road user fees, parking shortages and his pending retirement.See omnystudio.com/listener for privacy information.

Lance hosts Sports Talk as he breaks down all the excitement of the Bengals' 33-31 primetime victory over the Steelers.

Lance hosts Sports Talk as he breaks down all the excitement of the Bengals' 33-31 primetime victory over the Steelers.

Dr. Ricky Paris reminds us that we carry the glory and goodness of God and are responsible for manifesting His glory to the world around us. Sunday 10-12-2025

Lance talks with sports writer Terence Moore, documentary filmmakers Scott Thompson and Jesy Herron, and Cincinnati Cyclones captaion Justin Vaive. Plus, he takes your calls on whether the Reds should trade Hunter Greene for a bat.

Lance talks with sports writer Terence Moore, documentary filmmakers Scott Thompson and Jesy Herron, and Cincinnati Cyclones captaion Justin Vaive. Plus, he takes your calls on whether the Reds should trade Hunter Greene for a bat.

"The biggest shift was the consolidation that happened with the insurance carriers themselves. From 25 or more carriers to just four national carriers." - John RutledgeHow did health insurance get so broken? My guest this week, 40-year industry veteran John Rutledge of Marsh McLennan Agency, joins the show to walk us through the last 40 years of decisions that led us to the consolidated, expensive, and frustrating market we have today.John explains how the market went from over 25 competing carriers to just four national players. We discuss how the rise of carrier-owned PPOs squeezed out competition, and how the ACA later standardized coverage, locking employers into the "Buca box" with painfully limited options.But this isn't just a history lesson. We also discuss the solution that has emerged from the ashes of the old system: the explosion of self-funding and alternative risk models like captives that empower employers to finally break free.Tune in for a masterclass on how health insurance was broken, and more importantly, how we can start to fix it.Chapters:(00:00:00) How Health Insurance Was Broken Over The Last 40 Years (00:05:01) Why Self-Funding Has Exploded Since the ACA (00:09:58) How We Went From 25+ Carriers to Just 4 (00:12:56) The "Buca Box": Trapped with No Options (00:31:04) The Rise of Captives as an Alternative (00:40:31) Why Engaged Employers Win in a Captive (01:00:56) A Call to Action for Employers & AdvisorsKey Links for Social:@SelfFunded on YouTube for video versions of the podcast and much more - https://www.youtube.com/@SelfFundedListen/watch on Spotify - https://open.spotify.com/show/1TjmrMrkIj0qSmlwAIevKA?si=068a389925474f02Listen on Apple Podcasts - https://podcasts.apple.com/us/podcast/self-funded-with-spencer/id1566182286Follow Spencer on LinkedIn - https://www.linkedin.com/in/spencer-smith-self-funded/Follow Spencer on Instagram - https://www.instagram.com/selffundedwithspencer/

"The biggest shift was the consolidation that happened with the insurance carriers themselves. From 25 or more carriers to just four national carriers." - John RutledgeHow did health insurance get so broken? My guest this week, 40-year industry veteran John Rutledge of Marsh McLennan Agency, joins the show to walk us through the last 40 years of decisions that led us to the consolidated, expensive, and frustrating market we have today.John explains how the market went from over 25 competing carriers to just four national players. We discuss how the rise of carrier-owned PPOs squeezed out competition, and how the ACA later standardized coverage, locking employers into the "Buca box" with painfully limited options.But this isn't just a history lesson. We also discuss the solution that has emerged from the ashes of the old system: the explosion of self-funding and alternative risk models like captives that empower employers to finally break free.Tune in for a masterclass on how health insurance was broken, and more importantly, how we can start to fix it.Chapters:(00:00:00) How Health Insurance Was Broken Over The Last 40 Years (00:05:01) Why Self-Funding Has Exploded Since the ACA (00:09:58) How We Went From 25+ Carriers to Just 4 (00:12:56) The "Buca Box": Trapped with No Options (00:31:04) The Rise of Captives as an Alternative (00:40:31) Why Engaged Employers Win in a Captive (01:00:56) A Call to Action for Employers & AdvisorsKey Links for Social:@SelfFunded on YouTube for video versions of the podcast and much more - https://www.youtube.com/@SelfFundedListen/watch on Spotify - https://open.spotify.com/show/1TjmrMrkIj0qSmlwAIevKA?si=068a389925474f02Listen on Apple Podcasts - https://podcasts.apple.com/us/podcast/self-funded-with-spencer/id1566182286Follow Spencer on LinkedIn - https://www.linkedin.com/in/spencer-smith-self-funded/Follow Spencer on Instagram - https://www.instagram.com/selffundedwithspencer/

Lance is joined by James Rapien to discuss the Bengals' move for Joe Flacco, in addition to recapping the Reds' season and previewing the off-season.

Lance is joined by James Rapien to discuss the Bengals' move for Joe Flacco, in addition to recapping the Reds' season and previewing the off-season.

Lance breaks down the Bengals' midseason acquisition of Browns QB Joe Flacco and the implications for the rest of the season.

Lance breaks down the Bengals' midseason acquisition of Browns QB Joe Flacco and the implications for the rest of the season.

What if having the same gene as your sister doesn't mean you'll have the same outcome? What if trauma and nervous system dysregulation could be the difference between expressing a genetic disease—or not? In this mini episode, Dr. Aimie Apigian answers a question from Rachel in Texas, who discovered she carries the BRCA gene mutation. Despite making the same lifestyle changes as her sister—who also has the mutation—Rachel developed breast cancer while her sister remained healthy. Why? Dr. Aimie reveals the biological mechanism that connects nervous system dysregulation to genetic expression: oxidative stress. This episode offers a scientifically grounded yet hopeful perspective on why two people with identical genetics can have vastly different health outcomes—and what you can do about it. In this episode you'll hear more about: Why BRCA mutation carriers have a 45-72% lifetime breast cancer risk (versus 12-13% in the general population)—but not everyone with the gene develops cancer The biological link between nervous system dysregulation and oxidative damage to DNA How BRCA genes interact with NRF2 antioxidant pathways, creating increased vulnerability to oxidative stress Why both sympathetic activation (stress/anxiety) and dorsal vagal shutdown (depression/numbness) decrease your body's ability to clear oxidative stress The "calm alive" state: when your body naturally engages its healing and antioxidant repair mechanisms Dana's story from The Biology of Trauma—a physician with childhood trauma who found a breast lump and learned to repair nervous system dysregulation Practical tools: why vitamin C and antioxidant-rich foods (broccoli, blueberries) matter for genetic conditions How somatic self-practices can quickly shift your nervous system state and support cellular repair Why having a genetic condition doesn't mean you're powerless—epigenetics shows us DNA expression can change Genetics load the gun, but environment and nervous system state pull the trigger. This episode is a powerful reminder that even when you carry genetic risk, your nervous system regulation, oxidative stress levels, and daily practices can dramatically influence whether those genes are expressed. Your biology is not a life sentence.

Dr. Monty Pal and Dr. Matteo Lambertini discuss a compelling global study on the clinical behavior of breast cancer in young BRCA1 and BRCA2 carriers, the association of pre-diagnostic awareness of BRCA status with prognosis, and the importance of identifying healthy people who are at risk of carrying the BRCA1/2 pathogenic variants. TRANSCRIPT Dr. Monty Pal: Well, hello everyone, and welcome to the ASCO Daily News Podcast. I'm your host, Dr. Monty Pal. I'm a medical oncologist, professor, and vice chair of medical oncology at the City of Hope Comprehensive Cancer Center in Los Angeles. Now, when we think about genetic testing, whether for patients diagnosed with breast cancer or for other family members of them, it seems to be widely underutilized. Today, we're going to be discussing a recently published study in the Journal of Clinical Oncology that reported on the clinical behavior of breast cancer and specifically young BRCA1 and BRCA2 carriers, and the association of pre-diagnostic awareness of BRCA status with prognosis. I thought this was just a fascinating piece, and I honestly couldn't wait to have this conversation. It's a really compelling paper that highlights the importance of identifying healthy people who are at risk of carrying the BRCA1/2 pathogenic variants, and really the need for genetic counseling and testing to inform people about early detection that could lead to a better prognosis. I'm really delighted to welcome the study's lead author, Dr. Matteo Lambertini. He really needs no introduction. He's very well known in the breast cancer world for his amazing contributions to fertility in the context of breast cancer, to pregnancy in the context of breast cancer, and genetic testing. He's an associate professor at the University of Genova, and a breast cancer medical oncologist at the San Martino Polyclinic Hospital in Genova, Italy.  Dr. Lambertini, thank you so much for joining us today. Dr. Matteo Lambertini: Thank you very much, Dr. Pal. It's a great pleasure. Dr. Monty Pal: Oh, thanks. And just FYI, if you're listening in and you want to hear our disclosures, they're all listed at the transcript of this podcast.  So, I poured through this paper [Clinical Behavior of Breast Cancer in Young BRCA Carriers and Prediagnostic Awareness of Germline BRCA Status] yesterday, Dr. Lambertini, and first of all, congratulations on this study. This was a huge international multicenter effort, 4,752 patients. How did you pool all these patients with young breast cancer? Dr. Matteo Lambertini: Thanks a lot for the question. Yes, this was an effort made by several centers all over the world. The main idea behind the creation of this network that we have named as BRCA BCY Collaboration, was to get as many data as possible in a sort of niche patient population in the breast cancer field, meaning women diagnosed with breast cancer at the age of 40 years or younger, and all of them being BRCA carriers. We know that around, in the Western world, around 5% of breast cancer cases are being diagnosed under the age of 40 years, and among them around 10-15% are BRCA carriers. So, I would say it's a relatively rare patient population where we did not have a lot of evidence to support our choices in terms of counseling on treatment, prevention, and oncofertility as well. That was the idea behind the creation of this network that includes many centers. Dr. Monty Pal: Yeah. You know, what's so interesting about this is that you sort of draw this line between patients who have BRCA testing at the time of diagnosis and then BRCA testing earlier in their course and then leading to a diagnosis perhaps. And I think that's where really sort of the dichotomy in outcome sits. Can you maybe elaborate on this and tell us about timing of genetic testing in this study and what that meant ultimately in terms of prognosis? Dr. Matteo Lambertini: In this specific analysis from this large network, including almost 5,000 women with breast cancer diagnosed at the age of 40 years or younger and being a BRCA carrier, we looked specifically into the timing of genetic testing because this is a retrospective study and the criteria for inclusion are those that I have just mentioned, so diagnosis at a young age plus carrying germline BRCA pathogenic or likely pathogenic variant. In this analysis, we have looked into the time the patient has got the genetic testing and particular we focused on two populations: those that were diagnosed, knowing already to be a BRCA carrier, and those that got tested after being diagnosed with breast cancer. And the main findings from this analysis have been that knowing to be a BRCA carrier was associated with a lower stage at the time of diagnosis, meaning more T1 tumors, so a tumor less than 2 cm, more node-negative disease, and this translated into less aggressive treatment, so less often axillary dissection, less often use of chemotherapy and anthracycline-based chemotherapy. And even more importantly, we have seen a better overall survival for those patients that were diagnosed already knowing to be BRCA carriers as compared to those tested after breast cancer diagnosis. These results after adjusting for all the confounding, stage, treatment and so on, there was not significant anymore, meaning that it's not the timing of test per se that is probably leading to a better survival, but it is the fact that knowing to be a BRCA carrier would likely translate into having access to all the preventive measures that we have in this setting and this will translate into an overall survival benefit, so in terms of saving more lives in young BRCA carriers. Dr. Monty Pal: I think it's such an important point, and it's one that I think might sound implicit, right, but it needs to be proven, I think, through a study like this. You know, the fact that finding this early, identifying the mutation, doing enhanced screening, and so forth, is really going to lead to superior clinical outcomes. One of the things that I think many people puzzle over, including myself, is what to do? I personally occasionally will see BRCA altered patients in the context of prostate cancer. But that's a very different population of individuals, right? Typically older men. In young females with BRCA mutation, I guess there's a specific set of considerations around reproductive health. You'd already highlighted preventive strategies, but what sorts of things should we be talking about in the clinics once a patient's diagnosed and once perhaps their breast cancer diagnosis is established? Dr. Matteo Lambertini: Yes, exactly. Knowing to be a BRCA carrier has a lot of implications from prevention to treatment to survivorship issues including reproductive counseling. And this is important not only for the patient that has been diagnosed with breast cancer but also for all the family members that will get tested and maybe identify with this sort of genetic alteration before diagnosis of cancer. Why this is important is because we have access to very effective preventive measures, a few examples: MRI screening, which starts at a very young age and normally young women don't have an effective screening strategy outside the BRCA field. Also, primary preventive measures, for example, risk-reducing surgery. These women are known to have a high risk of breast cancer and high risk of ovarian cancer. So the guidelines are suggesting to undergo risk-reducing salpingo-oophorectomy at a young age, so 35 to 40 years in BRCA1 carrier, 40 to 45 years in BRCA2 carrier. And also risk-reducing mastectomy should be discussed because it is a very effective way to prevent the occurrence of breast cancer. And in some situations, including the setting that we are talking about, so young women with breast cancer, BRCA carrier, also risk-reducing mastectomy has shown to improve overall survival.  On the other side, once diagnosed with breast cancer, nowadays knowing to be or not a BRCA carrier can make a difference in terms of treatment. We have PARP inhibitors in the early setting, in the adjuvant setting as well as in the metastatic setting. And in terms of survivorship implication, one of the critical aspects for young women is the oncofertility care which is even more complicated when we talk about BRCA carriers that are women candidates for gynecological surgery at a very young age. So this sort of counseling is even more complicated. Dr. Monty Pal: One of the other things, and this is subtle in your paper and I hope you don't mind me bringing it up, is the difference between BRCA1 and BRCA2. It really got me thinking about that because there are differences in phenotype and manifestation. Do you mind just expanding on that a little bit for the audience because I think that's a really important reminder that you brought up in the discussion? Dr. Matteo Lambertini: The difference between BRCA1 and BRCA2 carriers has been known that there are different phenotypes of breast cancer that are more often diagnosed in these two different populations. Normally BRCA1 carriers have a higher likelihood to develop a triple negative breast cancer as compared to BRCA2 carriers, more likely to develop a hormone receptor-positive HER2-negative disease. In this study, again, a specific population of young women with breast cancer, we have seen the same findings, mostly triple negative disease in BRCA1 carrier, mostly luminal-like disease in BRCA2 carrier. But what's novel or interesting from this study is to look also at the age at the time of diagnosis of this disease. And particularly in BRCA1 carriers, we should be sort of more careful about diagnosis of breast cancer and also other primary tumors including ovarian cancer because the risk of developing these malignancies is higher even at a younger age as compared to BRCA2 carriers. And this has implications also in the primary and secondary prevention that we were talking about earlier. Dr. Monty Pal: Oh, interesting. I guess the fundamental question then from your paper becomes, how do we get at the right patients for screening for BRCA1 and BRCA2? And I realize our audience here is largely oncologists who are going to be listening to this podcast, oncology providers, MDs, nurses, etc. But maybe speak for a moment to the general practitioner. Are there things that, for instance, a general practitioner should be looking for to say, “Wait a minute, this patient's high risk, we should consider BRCA1, BRCA2 testing or germline screening”? Dr. Matteo Lambertini: Yes, it's a very important question for the breast cancer community. After the updated ASCO guideline, the counseling is way easier because right now the age cutoff goes up to 65 years, meaning that all the patients diagnosed with breast cancer below the age of 65 years should be tested these days. And then above the age of 65, there are different criteria like triple-negative disease or family history. From a general practitioner standpoint, it's of course a bit more difficult, but knowing particularly the family history of the person that they have in front will be crucial to know if there are cases of breast cancer diagnosed at a young age, maybe triple-negative cases, knowing cases of ovarian cancer in first-degree relatives or pancreatic cancer in first-degree relatives, and of course cases of prostate cancer as well. So, I would say probably mostly the family side will be important from a general practitioner perspective.  From an oncology one, the other point that I think is important to stress also based on the data that we have shown in this publication is that having a case of breast cancer known to carry a BRCA pathogenic or likely pathogenic variant. It means that all the people around this case should get tested and if found to be BRCA carrier and healthy carrier, these people should also undergo the primary and secondary prevention strategies because this is very critical also to improve their outcomes and try to avoid the developing of breast or ovarian cancer, but also in the case of diagnosis of this disease, a diagnosis at an earlier stage, as we have seen in this paper. Dr. Monty Pal: Brilliant. I'm going to diverge from our list of questions here and close by asking a question that I have at the top of my mind. You're very young. I know our podcast listeners can't see you, but you're very, very young. Dr. Matteo Lambertini: Thank you. Thank you for that. Not so young but yeah. Dr. Monty Pal: You have nearly 300 papers. Your H-index is 67. You've already made these seminal contributions, as I outlined it from the outset, regarding fertility, regarding use of GnRH analogs, regarding pregnancy and breast cancer. What are you studying now? What are you really excited about right now that you're doing that you think might potentially be practice changing? Give us a little teaser. Dr. Matteo Lambertini: Yeah. Thanks a lot, Dr. Pal. Receiving this compliment from you is fantastic. So, thanks a lot for that. From my side, in terms of my research, I've been interested in the field of breast cancer in young women since the start of my training. I've had very good mentors from Italy, from Europe, from the U.S. I'm still interested in this field, so I think we still have a lot to learn to try to improve the care of young women with breast cancer. For example, the oncofertility care, which is something I worked a lot over the past years. Now with all the new treatment options, there's a sort of new chapter of oncofertility counseling. So, what's the impact of immunotherapy? What's the impact of the new targeted agents?  More on the genetic aspects, now we know that there's not only BRCA1 or BRCA2. There are a lot of other different genes that may increase the risk of breast cancer and other malignancies. And also for these genes, we really don't have a lot of evidence to counsel women on prognosis, treatment, prevention strategy. So we need to learn way more for this special patient population that are quite rare, and so we really need a multicenter academic effort to try to give some evidence in this field. Dr. Monty Pal: Yeah. It's tough because these are rare circumstances, but, you know, I think that you've done really well to sort of define some collective experiences that I think really define therapy. I mean, I just remember when I was in training 25 years ago, just reading through textbooks where all the experience around breast cancer and pregnancy was really just very sort of anecdotal almost, you know? And so it's great to see that the state of the science has moved forward.  Well, gosh, I really enjoyed our conversation today. I think your study really reminds us how powerful genetic information is in terms of improving outcomes. And, you know, hopefully this will lead some individuals to perhaps test more broadly in appropriate settings. So, thank you so much, Matteo, for joining us today with your fantastic insights on the ASCO Daily News Podcast. Dr. Matteo Lambertini: Thank you very much, Dr. Pal. It's a real pleasure. Dr. Monty Pal: And thanks to our listeners too. You'll find a link to Dr. Lambertini's study in the transcript of this episode. Finally, if you value the insights that you heard today on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Thanks a ton. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:    Dr. Sumanta (Monty) Pal  @montypal  Dr. Matteo Lambertini @matteolambe   Follow ASCO on social media:     @ASCO on Twitter    ASCO on Bluesky   ASCO on Facebook     ASCO on LinkedIn     Disclosures:    Dr. Monty Pal:   Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview  Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical  Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis  Dr. Matteo Lambertini: Consulting or Advisory Role: Roche, Novartis, Lilly, AstraZeneca, Pfizer, MSD, Exact Sciences, Gilead Sciences, Seagen, Menarini, Nordic Pharma Speakers' Bureau: Takeda, Roche, Lilly, Novartis, Pfizer, Sandoz, Ipsen, Knight Therapeutics, Libbs, Daiichi Sankyo, Gilead Sciences, AstraZeneca, Menarini, AstraZeneca, Menarini Research Funding (Inst.): Gilead Sciences Travel, Accommodations, Expenses: Gilead Sciences, Daiichi Sankyo Europe GmbH, Roche

In this episode of The Long Haul, Adam sits down with Marcus Cooksey, founder and CEO of ⁠Duke.AI⁠ — a tech platform that helps small carriers simplify bookkeeping, automate back-office operations, and stay in control of their numbers without hiring a full accounting team.We talk about the real barriers small trucking companies face when it comes to automation, why AI doesn't have to mean “overcomplicated,” and how tools like ⁠Duke.AI⁠ are designed to meet you where you're at — not replace you. If you've ever said, “I just want something that works,” this episode is your blueprint. ⁠Follow The Long Haul Podcast⁠ ⁠Other FreightWaves Shows⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Find out what it really takes to build lasting partnerships in freight and how brokers and carriers can move beyond the transactional mindset in this episode with our returning guest, Dan Lindsey of Broker-Carrier Summit! Dan shares how they're changing the game by creating real face-to-face connections that drive millions in contracted freight, not just theory, but results. We talk about shifting the industry from a “someone has to lose” mentality to building true partnerships where brokers treat carriers like customers and vice versa, how technology fits into the equation—not as a replacement for trust, but as a tool to support it—and why the future of freight depends on balancing automation with human relationships!   Broker-Carrier Summit Orlando Registration: https://bcsfreightnetwork.com/ /  https://bit.ly/bcs-orlando   About Dan Lindsey Dan has been in the logistics industry since 2001 when he began working the preload shift for UPS. Since then, he has worked as a freight broker, operations manager, and business development leader in multiple segments of the industry. His commitment to “doing business the right way” led him to launch Linkage Logistics in March of 2020. Dan is also the driving force behind the Broker-Carrier Summit. Since his focus has always been on establishing deep, mutually agreeable partnerships, his hope is that closer cooperation between brokers and carriers will become the new normal in our industry.  

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For decades, while the rest of the world's powers have distracted and tangled themselves with wars of choice and blunder, the People's Republic of China has been watching, learning, and building. To what end?Returning to Midrats to discuss this and more will be Dean Cheng.Dean is a Senior Advisor, United States Institute of Peace; Non-resident Senior Fellow, Potomac Institute for Policy Studies; Non-resident Fellow, George Washington University Space Policy Institute.He recently retired after 13 years with the Heritage Foundation, where he was a senior research fellow on Chinese political and security affairs, and wrote on various aspects of Chinese foreign and defense policy.Prior to joining the Heritage Foundation, he was a senior analyst with the China Studies Division (previously, Project Asia) at CNA from 2001-2009.Before joining CNA, he was a senior analyst with Science Applications International Corporation (SAIC) from 1996-2001. From 1993-1995, he was an analyst with the US Congress' Office of Technology Assessment in the International Security and Space Division, where he studied the Chinese defense industrial complex.He is the author of the book Cyber Dragon: Inside China's Information Warfare and Cyber Operations (NY: Praeger Publishing, 2016), as well as a number of papers and book chapters examining various aspects of Chinese security affairs.Show LinksXi Jinping hails ‘unstoppable' China at landmark military parade, Financial TimesMore than pageantry, China's military parade shows off new missiles, drones and other equipment, The IndependentYJ-15 missile, YJ-19, YJ-17, YJ-20 hypersonic missiles, Global TimesNASA Names Astronauts to Next Moon Mission, First Crew Under ArtemisSummaryIn this conversation, Dean Cheng and the hosts discuss the implications of China's recent military parade, the evolution of its nuclear capabilities, and the modernization of its conventional military forces. They focus on China's ambition to establish a new world order and the strategic importance of its space and cyber capabilities. The discussion also touches on the role of coercion and deterrence in China's military strategy, as well as the challenges posed by its growing influence on the global stage.TakeawaysChina's military parade reflects its growing power and ambition.The presence of foreign leaders at the parade indicates shifting alliances.China is expanding its nuclear capabilities significantly.The PLA is focusing on both conventional and nuclear modernization.China's approach to military strategy includes both coercion and deterrence.The Chinese space program aims for long-term presence on the moon.China's cyber capabilities are evolving rapidly and pose a threat.The PLA's indigenous production capabilities are improving.China's military strategy is influenced by its historical context.The geopolitical landscape is changing with China's rise.Chapters00:00: Introduction to the Discussion on China and Military Parades03:07: Analysis of the Recent Military Parade and Its Implications06:05: The Evolution of China's Nuclear Capabilities12:07: China's Conventional Military Strategy and Modernization16:04: China's Global Influence and New World Order20:06: The Role of Coercion and Deterrence in Chinese Strategy26:12: China's Space Program and Technological Advancements34:59: China's Cyber and Information Warfare Capabilities43:46: The Future of China's Military and Strategic Developments

The biggest global shift is the cancellation of the de minimis rule, which previously offered a duty-free pass for low-value parcels but now adds huge friction by requiring formal customs entries. In response to this turbulence, companies like DHL are pouring millions into compliance, hiring over 880 new customs experts and investing heavily in AI and digital platforms to manage the rising complexity. The U.S. trucking market faces a capacity crisis marked by systemic overcapacity—a 54% surge in for-hire carriers since 2018 compared to only a 1.2% rise in freight volume. This environment has enabled dangerous "chameleon carriers" linked to hundreds of deaths, prompting the FMCSA to issue an emergency rule severely restricting non-domiciled Commercial Driver's Licenses (CDLs). Carriers must prepare for major cost inflation starting October 2025, when the U.S. is set to slap a new 25% import tariff on heavy-duty trucks, hitting an equipment market already reeling from low orders. Adding to regulatory uncertainty, the Department of Justice is seeking to dismiss California's lawsuit over Congress overturning key EPA waivers, even as Automated Manual Transmissions (AMTs) make driving easier but eliminate the traditional mechanical knowledge defining professional skill. Learn more about your ad choices. Visit megaphone.fm/adchoices

Join us as Pastor Brian Nhira brings an encouraging and timely message just for you! If you have never connected with us via our connection card, be sure to fill one out now! Connect with us at | bit.ly/RadiantConnectionCard Do you need prayer? Let us pray for you through this link | bit.ly/RadiantConnectionCard MusicBed SyncID: MB01SMWFTC7HQ4K

In this week's first episode, let's break down the real issues facing transportation professionals, particularly on the enforcement of Entry Level Driver Training and DOT policies, how tariff flip-flopping hurts U.S. businesses, and why our government's recurring budget crises create real risks for CDL issuance! Discover the market shift from LTL to truckload, where shippers can reduce costs, minimize damage risk, and improve transit times, a significant opportunity for freight brokers and carriers who understand how to educate their customers. I also cover the latest fraud case, exposing weaknesses in VIN verification and title systems, and why we need better government accountability instead of excuses!    Resources / References https://www.joc.com/article/truckload-carriers-capturing-more-ltl-shipments-fedex-freight-6083463 https://www.ttnews.com/articles/us-shutdown-looms https://cdllife.com/2025/trucking-company-owner-arrested-for-key-role-in-elaborate-rebuild-of-stolen-cmvs/?fbclid=IwZnRzaAM-Jk5leHRuA2FlbQIxMQABHmv18KUnE6QjG8f7WsNxby3Bl3alnYWjvy1KQDK21Ohc1gne2MZ83d2MbO-R_aem_QB-S7BJc5dLWhaYumAZxZg