Podcasts about kagel

In this episode, Earl Ingram hosts a panel from the "Get the Lead Out Coalition," featuring Robert Miranda, Dr. Yanna Lambrini, Paul Schwartz, and Kristen Payne. They discuss the issue of lead contamination in the drinking water at Milwaukee Public Schools (MPS), specifically highlighting schools like Golda Meir and Kagel. The guests criticize the MPS lead safety program, which only conducts annual inspections, claiming it is virtually ineffective and does not align with research findings. They reveal that lead levels at the Golda Meir Campus exceed the normal threshold by 20%, and point out that a staggering 85% of MPS schools built in earlier years are experiencing similar lead problems. MPS has a 1.4 million dollar budget and has no excuse to not address and fix the problem, especially when it pertains to the children all over Wisconsin. Questions or concerns - Dr Kristen Payne Leadsafeschoolsmke@gmail.com The Earl Ingram Show is a part of the Civic Media radio network and airs Monday through Friday from 8-10 am across the state. Subscribe to the podcast to be sure not to miss out on a single episode! To learn more about the show and all of the programming across the Civic Media network, head over to https://civicmedia.us/shows to see the entire broadcast line up. Follow the show on Facebook and X to keep up with Earl and the show! Guests: Robert Miranda, Dr. Yanna Lambrini, Kristen Payne, Paul Schwartz

De Duits-Argentijnse componist Mauricio Kagel werd vooral bekend door zijn onconventionele en vaak ook theatrale kijk op de eigentijdse muziek. In zijn Derde strijkkwartet wilde hij nader komen tot de klassieke traditie, tot de welluidendheid ervan en de vierdeligheid van het traditionele kwartetidioom. En typisch Kagel: met de nodige ironie en dubbele bodems. Enno Poppe […]

Dorothee Haddenbruch erzählt, wie sie zur neuen Musik, zur Improvisation und zur Komposition für Stummfilme gekommen ist. Wir tauchen tief in die Welt des Stummfilms ein. Sie spricht über Wuppertal, Kagel, Beethoven, To-Do-Listen, Pina Bausch, ihr Rechercheprojekt in NRW und vieles mehr.

In the early 20th century, the system of tonal harmony started to break down. The vertical accumulations of notes became too complex for our powers of memory and recognition, and some have suggested that this led to a loss of meaning and even humanity in music.In this lecture we will discuss expressive uses of atonality, and also the return of familiar chords to music, but outside the grammar that used to give them their logic.A lecture by Marina Frolova-Walker recorded on 18 May 2023 at LSO St Luke's Church, London.The transcript and downloadable versions of the lecture are available from the Gresham College website: https://www.gresham.ac.uk/watch-now/atonal-musicGresham College has offered free public lectures for over 400 years, thanks to the generosity of our supporters. There are currently over 2,500 lectures free to access. We believe that everyone should have the opportunity to learn from some of the greatest minds. To support Gresham's mission, please consider making a donation: https://gresham.ac.uk/support/Website:  https://gresham.ac.ukTwitter:  https://twitter.com/greshamcollegeFacebook: https://facebook.com/greshamcollegeInstagram: https://instagram.com/greshamcollegeSupport the show

Episode 97 Crosscurrents in Elektronische Musik from Germany Playlist Josef Anton Riedl, “Studie 1b, 1a” (1951) from Zeitgenössische Musik In Der Bundesrepublik Deutschland 3 (1950-1960) (1982 Deutscher Musikrat). Early example of German tape composition, categorized as musique concrète as it includes more than purely electronic sounds, but the edited and processed sounds of human voices and instruments (a harp, string bass) as well. But it's the vocal utterances and the way they were edited for effect with unpredictable silences that makes this work stand out for me. Riedl completed this after visiting and hearing musique concrète in France. After that, the Cologne studio came into existence and provided a new means to create electronic music not with microphones, but directly through electronic signals on tape. Riedl switched from making musique concrète to elektronische music. Realization by Riedl in association with the Studio für elektronische Musik des Westdeutschen Rundfunks, Köln (WDR, West German Radio in Cologne). 5:34 Karlheinz Stockhausen, “Étude” (1952) from Elektronische Musik 1952-1960 (1991 Stockhausen Verlag). Realized by Stockhausen during a stay to ORTF, Paris, where he learned the basics of musique concrète, which is how he categorized the piece before working purely electronic music at WDR. 2:56 Karlheinz Stockhausen, “Studie I” (1953) from Elektronische Musik 1952-1960 (1991 Stockhausen Verlag). One of two purely electronic “studies” composed by Stockhausen at the WDR. His serialist approach dictated all aspects of the sound and he composed the works using a graphical approach to depict the shapes and values of the volume, duration, pitch, and timbres of the sound. “Studie I” is among the first works of electronic music composed entirely for sine waves. Although the means for creating “Studie I” are readily available today using computer synthesis, its composition in 1953 required much manual intervention and ingenuity by Stockhausen. “Studie I” was a completely serialized composition in which the composer applied the mathematical analysis of tones and timbres to the way in which he generated, shaped, and edited sounds for a tape composition. With electronic tone generators and tape recorders at his disposal, Stockhausen felt that it was possible to “compose, in the true sense of the word, the timbres in music,” allowing him to synthesize from base elements such as sine waves the structure of a composition, its tone selection, and all of the audio dynamics such as amplitude, attack, duration, and the timbre of the sounds. He approached the composition by first recording a series of electronic tones that met certain pitch and timbral requirements that he prescribed and then using serial techniques to devise an organizational plan that determined the order and duration of the sounds as he edited them together. 9:23 Karlheinz Stockhausen, “Studie II” (1954) from Elektronische Musik 1952-1960 (1991 Stockhausen Verlag). The second of two purely electronic “studies” composed by Stockhausen at the WDR. For “Studie II,” Stockhausen extended his experiments with sine waves begun on “Studie I” by exploring the use of attack and decay characteristics as elements of composition. “Studie II” is one of the first post-war tape works to have a written score, albeit a graphic one in which overlapping translucent geometric shapes are used to denote the occurrence of a tone of a given amplitude in a given frequency with specific attack and decay characteristics. For “Studie II,” Stockhausen defined a set of frequencies based on the same ratio, resulting in an 81-tone scale of tones divided into one-tenth octave steps. The loudness and attack characteristics of the tones were divided into five stages. Tones based on such equal divisions of the frequency spectrum proved to be more harmonic when mixed. Stockhausen recorded short passages of the given tones and spliced them together in a loop that could be played repeatedly. These loops were then played through a reverberation system and then recorded to provide the final material with which the composer worked. Stockhausen's extensive use of reverberation added body and a noise quality to the sounds that embellished the raw sine tones. Using serial techniques to determine how to edit the material together, Stockhausen varied the attack characteristics and then also played some of the sounds backward to create a ramping decay that would abruptly cut off. His application of attack and decay characteristics in five prescribed stages of amplitude resulted in passages that were highly articulated by cascading, irregular rhythms. 2:59 Herbert Eimert, “Fünf Stücke” (1955/56) from Zeitgenössische Musik In Der Bundesrepublik Deutschland 3 (1950-1960) (1982 Deutscher Musikrat). Realization, H. Schütz, Herbert Eimert. Produced in the WDR studios, Cologne. Like Pierre Schaffer in France, Eimert had a background in creating music and sound for radio. He was one of the founding directors of the Cologne studio. Of the works included here, this one is a good example of his serialist approach that incorporated constantly changing combinations of defined sounds. 12:31 Gottfried Michael Koenig, “Klangfiguren II” (1955/56) from Zeitgenössische Musik In Der Bundesrepublik Deutschland 3 (1950-1960) (1982 Deutscher Musikrat). Realization by Gottfried Michael Koenig. Produced in the WDR studios,Cologne. Koenig was with the WDR Studio for ten years from 1954 to 1964. There he experienced the fundamental aspects of creating works with electronic sound devices, most of which had never been intended to make music. His work led him directly to computer music composition in the 1960s. In “Klangfiguren II” “every sound goes through several working steps, and both the original sound and the various intermediate results of the transformation process are heard.” 10:13 Karlheinz Stockhausen, “Gesang Der Jünglinge” (1955/56) from Zeitgenössische Musik In Der Bundesrepublik Deutschland 3 (1950-1960) (1982 Deutscher Musikrat). Realization by Gottfried Michael Koenig, Karlheinz Stockhausen. Produced in the WDR studios, Cologne. “Gesang der Jünglinge” was begun three years before Varèse completed “Poème électronique.” Like the Varèse work, “Gesang der Jünglinge” was produced using a host of electronic music production techniques cultivated earlier at the WDR studios. Stockhausen's approach was to fuse the sonic components of recorded passages of a youth choir with equivalent tones and timbres produced electronically. Stylistically, Stockhausen avoided the choppy, sharply contrasting effects that were so evident in many early magnetic tape pieces, instead weaving his sound sources together into a single, fluid musical element. He practiced his newly formed principles of electronic music composition, setting forth a plan that required the modification of the “speed, length, loudness, softness, density and complexity, the width and narrowness of pitch intervals and differentiations of timbre” in an exact and precise manner. The piece was painstakingly crafted from a visual score specifying the placement of sounds and their dynamic elements over the course of the work 13:03 Hermann Heiss, “Elektronische Komposition 1” (1956) from Zeitgenössische Musik In Der Bundesrepublik Deutschland 3 (1950-1960) (1982 Deutscher Musikrat). Realization by H. Schütz, Hermann Heiss. Produced in the WDR studios,Cologne.One does not often hear the name Heiss in relation to electronic music, although he went on the direct the Studio für Elektronische Komposition at the Kranichstein Music Instutute. At the time of this composition, he was focused on adapting electronic sounds to serial composition, for which he thought they were ideally suited. 5:11 Herbert Eimert, “Selection I” (1959) from Panorama Électronique: Electronic Experimental Music (1968 Limelight). For electronic and concrete sounds. 10:03 Herbert Eimert, “Sechs Studien” from Epitaph Für Aikichi Kuboyama (2005 Creel Pone). “Sechs Studien” was composed 1962 & realized by Leopold von Knobelsdorff and released in 1962 on the Wergo label. For electronic and concrete sounds. Interestingly, Eimert was also branching out with the addition of keyboards and what sounds like a theremin (although it might have been an Ondes martenot). The WDR studio had a keyboard instrument built by Harald Bode in 1953, the Melochord, along with a a Monochard made by Friedrich Trautwein. 17:48 Karlheinz Stockhausen, “Kontakte”(1959-60), parts 1 and 2 from the album Gesang Der Jünglinge / Kontakte (1962 Deutsche Grammophon). Composed and realized by Karlheinz Stockhausen. Produced in the WDR studios,Cologne. This work was adapted for phonograph from a 4-track original tape composition. Given that the album could only hold about 25 minutes of sound per side, they divided this piece in two and presented it as parts 1 and 2. I've joined the two parts together for the podcast. Note the experiments in sound movement between the speakers, a facet of electronic music about which Stockhausen was captivated. Around this time, he began using contraptions invented for the Cologne studio that would, for example, rotate a loudspeaker in space from which fixed microphones could pick up fluctuating signals based on the frequency of the speaker rotation. He would eventually use this same technique with live performances and 4 or more speakers to enable the sound to, in effect, rotate around the audience. By the time her wrote the liner notes for this recoding in 1962, he had “publicly performed” the work “more than thirty times in all large European cities as well as in Canada, the USA, and Brazil, and broadcast by most radio stations in both versions” (stereo and radio mixes). Stockhausen's sound palette had also grown more sophisticated by this point and contained many seemingly organic elements that stood out from the earlier, purely electronic music output of the WDR. It is also one of his last electronic works to exploit “total serialism” in which he painstakingly composed around the parameters of sound to “bring all properties” such as timbre, pitch, intensity, and duration under a single control." In 1981, music scholar David Toop looked back on this work and noted that Kontakte was really the culmination of Stockhausen's attempts to apply serialism technique to electronic music and succeeded only at the broadest level. Many other composers by this time had discovered that the fundamental nature of electronic music was to deal with the basic elements of sound and calling it serialism seemed quite meaningless. After all, the structures and tonalities were only as interesting as the listener found them to be. In his case, Stockhausen's uniquely vibrant and organic music, tinged with introspection and shocking contrasts, provided an emotional impact that serialism had never intended. Don't miss hearing the sequence beginning around 17 minutes in that presents a sequence of pulsing electronic tones that are sped up, at first, to sound like a smooth waveform but then lowered in frequency so that you hear the component particles and beats that comprise the faster tone. This was quite a trick using tape manipulation, probably requiring several playbacks of the sound at different speeds and then some eloquent mixing to join the pieces together. 34:33 Mauricio Kagel, “Transicion I” (1958) from Panorama Électronique: Electronic Experimental Music (1968 Limelight). This is one of several reissues of the work that was originally released by Philips (who owned Limelight, its US label). I have several versions of this work and this was in the best shape. Realization by Gottfried Michael Koenig, Mauricio Kagel. Produced in the WDR studios, Cologne. “Transicion I” for electronic sounds (1958) was composed when Kagel first traveled to Cologne, where he remained for the rest of his career. Clearly influenced by the Cologne school of serialism, “Transicion II” was characterized by an exploration of the many aural possibilities of his sound sources set to an arrhythmic, seemingly formless sequence of sonic exclamations without pattern. These works were similar in effect to some of Stockhausen's instrumental pieces of the same period, but radically different from the German's evolving approach to methodical tape composition. 12:49 Opening background music: Four short sections of “Kontakte” (1959-60) from Elektronische Musik 1952-1960 (1991 Stockhausen Verlag). These are not presented in their original order, but comprise Struktur parts 11, 12, 13a and 13b. the CD release on Stockhausen Verlag presents “Kontakte” not a one uniform track but as a set of parts originally created and edited together by Stockhausen. Opening and closing sequences voiced by Anne Benkovitz. Additional opening, closing, and other incidental music by Thom Holmes. See my companion blog that I write for the Bob Moog Foundation. For additional notes, please see my blog, Noise and Notations.

Auf Wunsch der Fans sind diesmal wichtige Staff-Mitglieder zu Gast. Leitender Physiotherapeut René Kagel und Mannschaftsarzt Dr. Gerd Rauch, der die MT-Profis als Orthopäde seit fast 30 Jahren von kleineren und größeren Wehwehchen befreit. Aufgrund der Verletzungsmisere im Kader haben beide aktuell reichlich zu tun. Wir sprechen mit den Experten über Ursachen, Behandlungen und neue individuelle Prophylaxe-Ansätze. Natürlich kommt der Spaß nicht zu kurz. Die Spieler verraten Moderator Patrick Schuhmacher über was sie was auf der Massagebank oder vor einer OP mit den Physios und dem Doktor plaudern. Und wie wichtig ihnen beide als absolute Vertrauenspersonen sind. Am Ende wird es knifflig: In der „Fan-Frage“ testet MT-Trommler Manuel die Verschwiegenheit von Gerd und René. Er will wissen, wer die größte Mimose im Spielerkader ist. Die Antwort hört ihr in der aktuellen Ausgabe von „Fulle Power – der Handballpodcast der MT Melsungen“ – präsentiert von ERIMA.

Thank you for listening! Here are some ways to learn more and stay connected! Subscribe to email. Subscribe to the daily devotional Explore recent messages This podcast was created by Pastor Derek Neider as a ministry of Awaken Las Vegas (formerly Calvary Chapel Las Vegas) find our website We are located at 7175 W. Oquendo Road, Las Vegas, NV 89113. Our gathering times are 9am & 11am Sundays and 6:30pm Thursdays.

Brandon Kagel and Deb Steffy are leading an outreach event in Las Vegas on October 29 where 10,000 Bibles will be given out and they need your help! Brandon talks about why evangelism shouldn't be so scary. He also talks about the difference between judging someone for something and holding them accountable. Brandon also talks about a testimony being a Churchy word, but it basically comes down to your story. He talks about why you shouldn't discount your story!

Thursday evening message from Pastor Brandon Kagel.

Sunday morning message from Pastor Brandon Kagel.

This week, Mari and Naomi are joined for the second time by Mari's roommate and bestie, Samantha! This episode is such a fun one! It's full of thought-provoking discussions and fun tips. The girls talk about... -which dating apps are best -Samantha's best and worst dating app experiences -practical tips for first dates -conversation tips for dates and general social situations -Samantha's thoughts on monogamy -the importance of being whole on your own before delving into dating and much more... Make sure to follow us on Instagram and share with a friend

Thursday Evening message from Pastor Brandon Kagel.

Hello and welcome back to the TAMS Percussion Podcast. After some time off to finish up a busy semester, we are back with some fantastic guests! In this episode, we are joined with two of the cohosts of the @Percussion Podcast, Dr. Karlyn Viña, and Dr. Ksenija Komljenović. We take time to discuss the perspective of female percussionists in the industry and talk about the experiences of these educators and how the modern percussion studio must be accepting of everyone. We are thankful for Karlyn and Ksenija sitting down at talking to us about these important issues in the community and we at TAMS hope that this may help you become a more informed ally! Praised by the South Florida Classical Review for her "dazzling" and "incisive" performance, Dr. Karlyn Viña is a dynamic and creative percussionist based in Virginia. Dr. Viña is the newly appointed Assistant Professor of Percussion at Shenandoah Conservatory in Winchester, VA, and previously taught at Florida International University and New World School of the Arts in Miami, FL. During the summers, Karlyn serves as a percussion faculty member at Interlochen Arts Camp in Interlochen, MI. Karlyn maintains a busy schedule as an orchestral, chamber, and solo percussionist, and has a particular interest in works that incorporate theatrical elements. In addition to her teaching and performing, Karlyn can be heard as a co-host on the @Percussion Podcast and is proud to serve on the Percussive Arts Society's Education Committee. Karlyn earned her Doctorate of Musical Arts in Percussion Performance from the University of Miami as a fellow of the Henry Mancini Institute. Her dissertation focuses on the performance of works for theatrical percussion by Globokar, Kagel, and Smith. She also holds degrees in Percussion Performance and Music Education from The Boston Conservatory and the University of Maryland. Karlyn is proud to endorse Grover Pro Percussion, Marimba One, and Zildjian cymbals. Dr. Ksenija Komljenović (Belgrade, Serbia), a prizewinner of the International Percussion Competition Luxembourg, is a percussionist, educator, and composer. Throughout her career, she has performed, taught, and studied across Europe, the United States, and Asia. Ksenija is the first woman from Serbia with a Doctor of Musical Arts in Percussion Degree. She holds the Assistant Professor of Percussion position at Texas A&M University-Corpus Christi. Ksenija serves as a producer and host on the At Percussion Podcast. She is on the organizational committees of the Tierras South Texas Percussion Competition and the SoundWaves Festival. Ksenija's devotion to percussion is shaped by her advocacy for contemporary and chamber music, as well as intercultural collaboration. Her three chamber ensembles (PNEUMA, Vesna Piano/Percussion Duo, Balkan Percussion Duo) unite some of the finest young performers from across the world. Ksenija holds degrees from the Frost School of Music at the University of Miami, Illinois State University, and the Faculty of Music in Belgrade, Serbia. Her compositions and arrangements are published by Bachovich Music Publications. Ksenija is a Marimba One artist. For the full bios of these fantastic artists, you can find them on their websites: https://www.ksenijakomljenovic.com/ http://www.karlynvina.com/ ​

Thursday Evening message from Pastor Brandon Kagel.

Thursday evening message from Calvary Chapel Las Vegas.

This week, Naomi and Mari are joined by Mari's amazing roommate, Samantha Kagel! Samantha shares stories from her career and life including why she quit her job at Google to move to Ireland, what it was like growing up with parents who left the Mormon Church, online dating, and much more. This is one of our favorite episodes yet! Don't forget to follow, rate, subscribe and share. Instagram: instagram.com/_richnotfamous_

Thursday evening special message from Calvary Chapel Las Vegas.

Lieferzeiten verlängern sich, Lieferketten sind unterbrochen, die Nachfrage ist hoch: die Preise steigen. Doch höhere Preise durchzusetzen verlangt Verhandlungskunst: genau darum geht es in dieser LinkedIn-Live-Session! Mit Daniel O. Kagel und Stephan Kober Link zum LinkedIn Live Video

In this episode number 9, we welcome Ela Kagel on online communities. The 'Capacity Building for European Capitals of Culture' project's Academy Camps aim to boost and promote dialogue between European Capitals of Culture (ECOCs) and in turn share good practices and learning with the aim to build bridges between different cities.

Sunday morning message from Calvary Chapel Las Vegas.

Sunday evening worship service from Calvary Chapel Las Vegas.

durée : 02:57:20 - Eté Classique Matin - La Rose des Vents est notre boussole cette semaine dans les matins d'Eté classique. Aujourd'hui, cap vers l'est ! Une promenade musicale dans les pays d'Europe de l'est et notre point de départ du voyage : "EST", la première pièce de la "Rose des Vents" de Maurizio Kagel

Sie ist Kostüm- und Bühnenbildnerin, Psychotherapeutin und Malerin – und sie trägt einen prominenten Namen: Kagel. Deborah Kagel. Sie ist die Tochter des Komponisten Mauricio Kagel und der Künstlerin Ursula Burghardt-Kagel. Und sie hat ein Buch geschrieben mit ihren Erinnerungen an ein „ungewöhnliches Familienleben“, wie es auch im Titel heißt. Christoph Vratz hat das Buch gelesen.

In dieser Folge des Boudoir Podcast unterhalte ich mich Daniel Kagel. Daniel ist Vertriebsprofi und beantwortet mir alle meine Fragen zum Thema Verkauf. Wahrscheinlich geht es vielen Fotografen so wie mir, ich will nur fotografieren und kann mich bzw. meine Bilder nur schlecht verkaufen. Daniel bringt an dieser Stelle Licht ins Dunkel und es gibt viel zu lernen. — Boudoirpodcast Der Podcast zur Boudoirfotografie von Boris Mehl

In dieser Folge des Boudoir Podcast unterhalte ich mich Daniel Kagel. Daniel ist Vertriebsprofi und beantwortet mir alle meine Fragen zum Thema Verkauf. Wahrscheinlich geht es vielen Fotografen so wie mir, ich will nur fotografieren und kann mich bzw. meine Bilder nur schlecht verkaufen. Daniel bringt an dieser Stelle Licht ins Dunkel und es gibt viel zu lernen. — Boudoirpodcast Der Podcast zur Boudoirfotografie von Boris Mehl Der Host: Boris Mehl https://boudoirfotograf.de info@borismehl.de 0176 24335371

Guitare synthé pour les basses "pad" et au piano : Jean-Philippe Causse pour "rondeña", à la fin. C'était l'ouverture d'un concert de musique Argentine. Je posterai prochainement une autre œuvre de Kagel issue de ce programme.

De la figure du diable violoniste au quadrille infernal, prenez votre courage à deux mains et apprêtez-vous à partir pour une chevauchée effrénée vers le pandémonium… A travers des oeuvres de Liszt, Stravinsky, Ravel, Moussorgsky, Schubert, Tartini, ou encore Kagel, découvrons ensemble la position paradoxale de la musique vis-à-vis des figures méphistophéliques qu’elle évoque. Tantôt […]

Pastor Brandon Kagel talks about how to share your faith! He's the Evangelism Ministry Pastor at Calvary Chapel Las Vegas. Brandon talks about asking questions, sharing our story and leading... Scott Herrold is known for his interviews. He does a daily radio show on SOS Radio. This postcast is conversations about worldview, faith and culture with famous personalities.

★ Support the show by becoming a patron: https://www.patreon.com/atpercussion ★ Follow us on: Facebook: https://www.facebook.com/atperc Instagram: https://www.instagram.com/atpercussion/ PodBean: https://atpercussion.podbean.com/ Hosts: Casey Cangelosi, Ben Charles, Karli Viña, and Ksenija Komljenović Intro music by Reese Maultsby - reesemaultsby.com Watch here  Listen below   0:00 Intro and hello 2:00 Casey: Today in music history.  Beatles auction, fire at the Met.   10:57 Welcome, Dr. Louise Devenish! 13:27 Your research and fellowship project? Collaboration. 16:00 Interest in music of Australia?  17:50 Your publication on under represented artists?  29:14 Your book, "Global Percussion Innovations" ? 30:35 Excerpts of Louise performing.  Collaboration. 37:00 How do you encourage students to pursue commissions and collaborations?  39:00 Kagel's Dressur and "Never Tilt Your Chair". 44:20 Karli: Louise's composition "Taut" 52:40 Karli: Working through COVID, "Crisis Fatigue" article.  What have we all been doing to keep active? 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.30.068726v1?rss=1 Authors: Hwang, D., Dismuke, T., Tikunov, A., Rosen, E., Kagel, J., Ramsey, J., Lim, C., Zamboni, W., Kabanov, A., Gershon, T. R., Sokolsky-Papkov, M. Abstract: We report a novel, nanoparticle formulation of the SHH pathway inhibitor vismodegib that improves efficacy for medulloblastoma treatment while reducing toxicity. Systemic therapies for brain tumors are complicated by restricted blood-brain barrier (BBB) permeability and dose-limiting extraneural toxicity, therefore improved delivery approached are needed. Here we show how a nanoparticle delivery system addresses these obstacles, bringing new efficacy to previously ineffective therapy. Vismodegib has been a promising agent for patients with SHH-subgroup medulloblastoma and is FDA-approved for basal cell carcinoma. However, vismodegib has limited benefit for patients with SHH-driven medulloblastoma, due to off-target toxicities and the development of resistance during therapy. We encapsulated vismodegib in polyoxazoline block copolymer micelles (POx-vismo). We then evaluated POx-vismo using transgenic mice engineered to develop endogenous medulloblastomas, testing the novel agent in a preclinical model with native vasculature and tumor microenvironment. POx-vismo showed improved CNS pharmacokinetics and reduced systemic and bone toxicity. Mechanistic studies show that POx nanoparticles did not enter the CNS, but rather acted within the vascular compartment to improve drug delivery by decreasing drug binding to serum proteins and reducing the volume of distribution. POx-vismo demonstrated improved efficacy, extending the survival of medulloblastoma-bearing mice. Our results show the potential for a simple, non-targeted nanoparticle formulation to improve systemic brain tumor therapy, and specifically to enhance vismodegib therapy for SHH-driven cancers. Copy rights belong to original authors. Visit the link for more info

Nate and Bobby T have been grounded from exploring exciting historical building. For now until the quarantine comes to a close, these spelunkers will bring you awesome stories of those Milwaukee figures that helped shape the landscape of our city.

Nate and Bobby T have been grounded from exploring exciting historical building. For now until the quarantine comes to a close, these spelunkers will bring you awesome stories of those Milwaukee figures that helped shape the landscape of our city.

Want to be featured as a guest on Making Data Simple? Reach out to us at [almartintalksdata@gmail.com] and tell us why you should be next. AbstractIn this episode of Making Data Simple, we are joined with two very established members of the Informix user community. Art Kagel, President and Principal Consultant at ASK Database Management, and Lester Knutsen, President and Principal Database Consultant at Advanced DataTools Corporation. Together with host Al Martin, they touch on the state of the database and technology industry, sharing their wisdom of how far we have actually come. Tune in for a high-level discussion immersed in the world of data. Connect with ArtLinkedInTwitterConnect with LesterLinkedInTwitterShow Notes03:38 - Here are the best diving sites in Indonesia, according to divezone.net.20:15 - Check out this Globe News Wire article, predicting future growth for the enterprise data industry.28:05 - Not sure what a five nines system is? Find out here.Connect with the TeamProducer Liam Seston - LinkedIn.Producer Lana Cosic - LinkedIn.Producer Meighann Helene - LinkedIn. Producer Mark Simmonds - LinkedIn. Host Al Martin - LinkedIn and Twitter.

Want to be featured as a guest on Making Data Simple? Reach out to us at [almartintalksdata@gmail.com] and tell us why you should be next. AbstractIn this episode of Making Data Simple, we are joined with two very established members of the Informix user community. Art Kagel, President and Principal Consultant at ASK Database Management, and Lester Knutsen, President and Principal Database Consultant at Advanced DataTools Corporation. Together with host Al Martin, they touch on the state of the database and technology industry, sharing their wisdom of how far we have actually come. Tune in for a high-level discussion immersed in the world of data. Connect with ArtLinkedInTwitterConnect with LesterLinkedInTwitterShow Notes03:38 - Here are the best diving sites in Indonesia, according to divezone.net.20:15 - Check out this Globe News Wire article, predicting future growth for the enterprise data industry.28:05 - Not sure what a five nines system is? Find out here.Connect with the TeamProducer Liam Seston - LinkedIn.Producer Lana Cosic - LinkedIn.Producer Meighann Helene - LinkedIn. Producer Mark Simmonds - LinkedIn. Host Al Martin - LinkedIn and Twitter.

A.G. Steer Professor of German and associate dean in the Franklin College of Arts and Sciences, Martin Kagel is co-director of the Berlin Seminar in Transnational European Studies. A joint initiative of the University of Georgia Franklin College and the Willson Center for Humanities and Arts, and the Nanovic Institute for European Studies at the University of Notre Dame, the week-long residency in Berlin each June is in its second year of expanding the understanding of transnational Europe among U.S.-based scholars and advancing the discourse on campus on issues related to Europe, the E.U., and Germany's role in the European Union.Alan Flurry and Kagel discuss political, economic and human rights issues from the most recent Berlin seminar including climate change, Brexit, Immigration, nationalism, populism, film, photography, the media, migration, and more.

Si parla de "La compagnia del Cigno", fiction di RAI 1. Recensioni de "Il flauto magico" e "Moglie venduta" della Bayerische Staatsoper (Vittorio Bianchi). Ospiti in studio Sandro Gorli e Marcello Parolini per la nuova stagione di Rondò di Divertimento Ensemble (focus su Kagel e Lachenmann).

Si parla de "La compagnia del Cigno", fiction di RAI 1. Recensioni de "Il flauto magico" e "Moglie venduta" della Bayerische Staatsoper (Vittorio Bianchi). Ospiti in studio Sandro Gorli e Marcello Parolini per la nuova stagione di Rondò di Divertimento Ensemble (focus su Kagel e Lachenmann).

Si parla de "La compagnia del Cigno", fiction di RAI 1. Recensioni de "Il flauto magico" e "Moglie venduta" della Bayerische Staatsoper (Vittorio Bianchi). Ospiti in studio Sandro Gorli e Marcello Parolini per la nuova stagione di Rondò di Divertimento Ensemble (focus su Kagel e Lachenmann).

How can we create good governance in cooperativesin the blockchain space? And maybe beyond? This is the leading question guiding through this roundtable, which takes a look at real life examples of tech cooperatives (Rchain) and engages into a discussion on how to improve, expand and share the knowledge of alternative governance models enhanced by technology beyond the confining boundaries of the crypto-space.

Ela Kagel is the Co-Founder and Managing director of SUPERMARKT Berlin and an RChain Europe board member. Rashid Owoyele is a Community and Strategy Director for RChain Europe.

Ela Kagel is the Co-Founder and Managing director of SUPERMARKT Berlin and an RChain Europe board member. Rashid Owoyele is a Community and Strategy Director for RChain Europe.

The Vienna Piano Trio performs music by Haydn, Kagel, and Tchaikovsky.

Fra sommermusikfestivalen på Mols med Carl Nielsen Kvintetten, der spiller musik af Ligeti, Danz, Rakhmaninov, Kagel, Ives og Carl Nielsen. (Agri Kirke, Knebel 26. juli). Ca. kl. 21.30: Trio Gemini, der er debuteret fra Det Kgl. Danske Musikkonservatorium, spiller Mendelssohn. Vært: Klaus Mølller-Jørgensen.

Born in Tucson, Arizona, where he received his undergraduate degree in Education from Northern Arizona University, and received a double major Special Education and Physical Education. He returned to school to receive a Master’s Degree in Orientation and Mobility Specialist. He has taught the blind how to travel for over 30 years and has been  has been a Special Education teacher for the last 10 years. While being a single father of 4 kids, triplets plus one, he taught various courses on parenting classes, drug education, motivational training, and classes on Moving Through your Fears and presentations on the Attainment of Peace, and Talks on Forgiveness. This is an interview  about Forgiveness and how Joshua’s life helped guide Rob’s life to a deeper meaning. How does one forgive and not hate? How can one forgive another person that has taken someone that has been so dear to your heart? This interview will inspire you, lighten up your life, you will laugh, and there will be some tears. Join Aging Younger radio and listen as Rob Kagel answers these questions.  You will be astonished to learn how this man forgave the murderer of his son, Joshua Ben Kagel.