Podcasts about Microcephaly

Steph talks about identification of gut bacteria that can digest protective mucosal antibodies and Vincent covers a new paper on Zika virus that implicates fetal phagocytes in brain invasion, which may provide insight into the devastating microcephaly outcome of infection during pregnancy. Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Gut bacteria induce mucosal immunodeficiency (Science) Contribution of fetal mononuclear phagocytes to Zika virus neuroinvasion (Cell) TWiV468 discusses Zika and brain slice infection model. Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv Information on this podcast should not be construed as medical advice.

Join us as we discuss cytomegalovirus infection in pregnancy. CMV is a common cause of hearing loss in newborns and can cause other congenital anomalies. It is a common infection that's easily transmitted. Learn about it and what you can do.

Meet Lieschè, a brave little girl with a heartwarming smile that lights up the room. Born with Spastic Quadriplegic Cerebral Palsy and Microcephaly, her journey has been one of resilience and determination. Despite the challenges, she inspires everyone with her unwavering spirit. Her family works tirelessly to give her the best care, but they need a helping hand to improve her quality of life. Together, we can make a difference. Hot Cares

Send us a Text Message.In this episode of Ginger Biz, the Podcast, I share personal lessons learned from my sister Doina, who has Microcephaly and autism. Adopted from a Romanian orphanage, Doina's unique journey taught me invaluable lessons in patience, advocacy, gratitude, and unconditional love, shaping both my personal life and leadership approach. From her love of orange food to her incredible strength and resilience, Doina's influence is profound. These experiences highlight the importance of patience, standing up for beliefs, expressing gratitude, advocating for others, and leading with empathy. I hope these insights inspire you to appreciate the unique individuals in your life and integrate these lessons into your leadership style.______________________________You can find me here:Instagram: @gingerbizWebsite: https://www.katymurrayphotography.com/Facebook: https://www.facebook.com/groups/TipsandTricksforyourbusinessTwitter: https://twitter.com/GingerBizKM

Our guest this week is Kelley Coleman of Los Angeles, CA a feature film maker turned author, disability advocate, wife and mother of two including a son with an undiagnosed rare disease and many disabilities.Kelley and her husband, Eric, have been married for 16 years and are the proud parents of two boys: Sean (12) and Aaron (10) who has multiple disabilities, including: An Undiagnosed Genetic DisorderCortical Visual ImpairmentFailure to ThriveAutismEpilepsyCerebral PalsyMicrocephaly, andA Feeding TubeKelley is also the author of Everything No One Tells You About Parenting a Disabled Child, available on Amazon.Kelley has lots to say about a host of supporting organizations, including the Undiagnosed Disease Network, Canine Companions, and Painted Turtle Camp to name a few.   That's all on this episode of the SFN Dad to Dad Podcast.  Show LinksEmail - kelleyellek@gmail.comWebsite – https://www.kelleycoleman.com/Facebook - https://www.facebook.com/kelley.coleman.56Instagram - https://www.instagram.com/hellokelleycoleman/Undiagnosed Diseases Network - https://undiagnosed.hms.harvard.edu/Canine Companions - https://canine.org/Painted Turtle local camp - https://www.thepaintedturtle.org/ SNAP Special Needs Aquatic Program with Stepping Stones https://snapaquatics.org The book -Everything No One Tells You About Parenting A Disabled Child. Your Guide to the Essential Systems, Services, and Supports - https://tinyurl.com/5casy743Special Fathers Network - SFN is a dad to dad mentoring program for fathers raising children with special needs. Many of the 700+ SFN Mentor Fathers, who are raising kids with special needs, have said: "I wish there was something like this when we first received our child's diagnosis. I felt so isolated.  There was no one within my family, at work, at church or within my friend group who understood or could relate to what I was going through."SFN Mentor Fathers share their experiences with younger dads closer to the beginning of their journey raising a child with the same or similar special needs. The SFN Mentor Fathers do NOT offer legal or medical advice, that is what lawyers and doctors do. They simply share their experiences and how they have made the most of challenging situations.Check out the 21CD YouTube Channel with dozens of videos on topics relevant to dads raising children with special needs - https://www.youtube.com/channel/UCzDFCvQimWNEb158ll6Q4cA/videosPlease support the SFN. Click here to donate: https://21stcenturydads.org/donate/Special Fathers Network: https://21stcenturydads.org/

Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and potential treatments for conditions like Alzheimer's and ALS. The dialogue also delves into the transformative impact of space environments on scientific discoveries, from understanding bacterial growth to developing novel therapies. Through collaborative efforts, they strive to revolutionize healthcare, offering hope for patients and pushing the boundaries of human knowledge. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39632]

Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and potential treatments for conditions like Alzheimer's and ALS. The dialogue also delves into the transformative impact of space environments on scientific discoveries, from understanding bacterial growth to developing novel therapies. Through collaborative efforts, they strive to revolutionize healthcare, offering hope for patients and pushing the boundaries of human knowledge. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39632]

Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and potential treatments for conditions like Alzheimer's and ALS. The dialogue also delves into the transformative impact of space environments on scientific discoveries, from understanding bacterial growth to developing novel therapies. Through collaborative efforts, they strive to revolutionize healthcare, offering hope for patients and pushing the boundaries of human knowledge. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39632]

Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and potential treatments for conditions like Alzheimer's and ALS. The dialogue also delves into the transformative impact of space environments on scientific discoveries, from understanding bacterial growth to developing novel therapies. Through collaborative efforts, they strive to revolutionize healthcare, offering hope for patients and pushing the boundaries of human knowledge. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39632]

Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and potential treatments for conditions like Alzheimer's and ALS. The dialogue also delves into the transformative impact of space environments on scientific discoveries, from understanding bacterial growth to developing novel therapies. Through collaborative efforts, they strive to revolutionize healthcare, offering hope for patients and pushing the boundaries of human knowledge. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39632]

Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and potential treatments for conditions like Alzheimer's and ALS. The dialogue also delves into the transformative impact of space environments on scientific discoveries, from understanding bacterial growth to developing novel therapies. Through collaborative efforts, they strive to revolutionize healthcare, offering hope for patients and pushing the boundaries of human knowledge. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39632]

Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and potential treatments for conditions like Alzheimer's and ALS. The dialogue also delves into the transformative impact of space environments on scientific discoveries, from understanding bacterial growth to developing novel therapies. Through collaborative efforts, they strive to revolutionize healthcare, offering hope for patients and pushing the boundaries of human knowledge. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39632]

Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and potential treatments for conditions like Alzheimer's and ALS. The dialogue also delves into the transformative impact of space environments on scientific discoveries, from understanding bacterial growth to developing novel therapies. Through collaborative efforts, they strive to revolutionize healthcare, offering hope for patients and pushing the boundaries of human knowledge. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39632]

Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and potential treatments for conditions like Alzheimer's and ALS. The dialogue also delves into the transformative impact of space environments on scientific discoveries, from understanding bacterial growth to developing novel therapies. Through collaborative efforts, they strive to revolutionize healthcare, offering hope for patients and pushing the boundaries of human knowledge. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39632]

Ash has been listening to the podcast since episode 40 so I've been in her ears every week for six years. Today she takes us through her three pregnancies and births, nodding to the importance of being prepared - listening to all kinds of births - and also accepting intervention when necessary. She navigated postnatal depression in her first postpartum but reconnected with her psychologist and went into her second pregnancy feeling grounded. She planned a homebirth and embraced spontaneous contractions, leaning into the pain. Her birth was straightforward but she immediately noticed that baby Oliver's head was a bit small and 12 weeks later they began a long series of tests and medical appointments that eventually led to the diagnosis of a rare variant of microcephaly. Ash details her grief and shock, her self-blame and the eventual acceptance that life would look very different for the whole family. Her third birth was an incredibly healing experience and as she gets into the groove of raising three boys, she admits that social media has been such a blessing as she's connected with parents of children with disabilities, helping her feel less alone and emotionally supported. _________ What makes The Birth Class so unique? Instead of learning from one person with one perspective, we've gathered nine perinatal health specialists to take you through everything you need to know about labour and birth. Evidence based information is key to thorough preparation. In The Birth Class you'll learn from:5 midwives and an obstetrician, a women's health physiotherapist, yoga teacher and birth doula.Listen in your own time and as many times as you like so you understand: the process of labour and the hormones involved the benefits and risks of interventions your pain-relief options what happens in an emergency caesarean what to expect in the hours after birth active preparation for a VBAC Plus, you'll be taught practical birth skills that will help you navigate the twists and turns of labour. The Birth Class is accessible birth education that's both conversational and wise. Best of all, it will start a conversation with you and your support person so you can both feel prepared and confident to make informed choices; the foundation of a positive birth experience.See omnystudio.com/listener for privacy information.

AYUREKHA | ആയുർരേഖ | MICROCEPHALY Microcephaly is a condition where a baby's head is much smaller than expected. During pregnancy, a baby's head grows because the baby's brain grows. Microcephaly can occur because a baby's brain has not developed properly during pregnancy or has stopped growing after birth, which results in a smaller head size.

Clinical psychologist and mother Dr. Erica Rozmid, PhD shares her very personal experience with microcephaly, a condition where a baby's head is much smaller than expected. Dr. Erica shares her very raw and emotional journey through pregnancy loss, medical abortion, and the birth of her living child. Content Warning: This episode discusses a mother's personal recounting of the discovery of a devastating fetal medical condition mid pregnancy and the subsequent termination of the pregnancy for medical reasons. Listener discretion is advised. Connect with Dr. Erica online: https://www.tfmrpsychologist.com/ and https://claritycbt.com/ Erica Rozmid on social media: https://www.instagram.com/tfmrpsychologist/  Check out the Informed Pregnancy Blog post about life long mental health here: https://www.informedpregnancy.com/single-post/nurturing-touch-in-the-first-three-years-promotes-lifelong-mental-wellness-greer-kirshenbaum-phd Keep up with Dr. Berlin and the Informed Pregnancy Project online! www.informedpregnancy.com www.instagram.com/doctorberlin/ www.facebook.com/InformedPregnancy www.twitter.com/doctorberlin Learn more about your ad choices. Visit megaphone.fm/adchoices

Malaria is supposedly on the rise in the United States, where seven cases between Florida and Texas have been reported in the last few weeks. The CDC issued a public health alert as a result and the media collectively is spreading the terror of malaria with graphs, charts, stories, and symptoms. The strange thing is that malaria is always present, particularly in those two states, where in 2012 cases were 102 in Texas and 59 in Florida. Over the years those numbers went up and down, peaking in 2019 and then dropping significantly in 2020. This is why the media can claim cases are on the rise even if they are below the previous decade peak. From NPR to the New Scientist there are, of course, solutions to this terrible outbreak that isn't much of an outbreak: vaccines and genetically modified mosquitoes that could produce antibodies against malaria parasite. However, these same genetically modified insects have been in development since 2008 and were released in Florida after 2015. They were created with money from the B&MGF: “a mosquito that can produce and secrete a malaria vaccine protein.” But what if gm-mosquitoes are another alternative lab-leak theory? Malaria's symptoms are themselves invariably described in the same way that heat stroke symptoms are: headaches, fever, muscle aches, nausea, etc. Any mosquito issue, genetically modified or otherwise, can of course be treated with new drugs and chemicals, like the Pyriproxyfen that caused Microcephaly which was blamed on zika and mosquitos.This show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/5328407/advertisement

In this episode, Rina and Lauren talk with Jazz Manley about her experience of searching for answers and a diagnosis for her son Max. Jazz is candid, being open about her own vulnerability and mental health struggles. She discusses her son's difficult birth and the challenges she faced when he was young and her concerns surrounding her son were not shared by others. We also discuss how Jazz came to discover that she herself was autistic. Jazz provides a raw, honest, but also funny and heart-warming account of coming through this difficult period in her family's life. This episode contains reference to and details around attempted suicide. It is important to stress that we are not mental health experts, but we have spoken to Jazz outside of the podcast to ensure that she is able to access more support. If you are affected by the content or concerned about anyone you know, please reach out for help. Suicide is preventable, and support is available. We have included some links below. Contact Us | Samaritans Where to get urgent help for mental health - NHS (www.nhs.uk)Useful contacts - helping someone who feels suicidal - MindContent WarningsSuicide Traumatic birth stories DiagnosisGuest BiographyJazz is 28 years old and lives in Cheshire with partner, Ryan and their 5 year old son, Max. Max is suspected to have a rare, (as yet) undiagnosed genetic condition which has culminated in autism, global development delay, hypermobility, low muscle tone, microcephaly, dyspraxia and febrile convulsions. Jazz is also autistic, having been diagnosed at the age of 24.Jazz has an undergraduate degree in Law and has worked as a paralegal and a police officer. Due to Max's growing needs, she is now self-employed as an accounts assistant and recently set up her own payroll company with her best friend, another special needs parent. Jazz's biggest passions in life (besides her family) are music, books and writing. When Jazz finds an unusual moment for herself you will find her playing guitar, some sport, reading Harry Potter or Game of Thrones books or blogging on her social media account, Autiemum & Max.Instagram - @autiemumandmaxFacebook – Autiemum & MaxTikTok - @autiemumandmaxResource Links What is autism? - NHS (www.nhs.uk)Microcephaly (who.int)What Is Global Development Delay? Find Out More | Mencap Hosted on Acast. See acast.com/privacy for more information.

Dads Shawn Francis and Brian Altounian discuss the launch of their Men's Group for men who are caregivers or partners to those with special needs & why such a group or space is important. Additionally the dads discuss why financial literacy is important to special needs families & basic ingredients of a plan should consist of. Dads Shawn Francis and Brian Altounian discuss the launch of their Men's Group for men who are caregivers or partners to those with special needs & why such a group or space is important. Additionally the dads discuss why financial literacy is important to special needs families & basic ingredients of a plan should consist of. Just Two Dads Facebook=https://www.facebook.com/wearejusttwodads Youtube=https://www.youtube.com/@justtwodads8081 Linkedin=https://www.linkedin.com/in/justtwodads/ Tik Tok=https://www.tiktok.com/@justtwodads Instagram=https://www.instagram.com/just_two_dads_podcast/ Registration link for our men's group which launches on 4/22/23= https://docs.google.com/forms/d/1u6_vPhQ8Qp7zhmqEbb3kelK1mUM3Zh48pIP0FayRCHw/edit Shawn Francis Originally from St. Thomas United States, Virgin Islands, Shawn Francis is a dedicated husband, and a father to 7 children.. 2 of which (ages 28 and 31) are daughters from his wife's previous marriage, 4 of which (two boys and two girls, ages 18-22) are his sister-in-law's biological children whom he and his wife Laura became legal guardians to over a decade ago and completed the adoption process four years ago, and one of which is his 16-year-old biological son who was diagnosed with autism at the age of three. He has nearly two decades and a half of experience serving and educating families about their finances. Shawn has served as a member of the Autism Parents Advisory Board at Children's Hospital of Los Angeles and as a volunteer Ambassador with Autism Speaks. Just over 5 years ago, he decided to focus a portion of his business on serving other families with members who have special needs. He is the co-creator & co-host of the weekly podcast, Just Two dads, which spotlights those who serve the special needs community and beyond as well as those who serve as an inspiration to all. He lives in Los Angeles, California. Facebook=https://www.facebook.com/contactshawnfrancis/ Instagram=https://www.instagram.com/iamshawnfrancis/ Linkedin=https://www.linkedin.com/in/shawnf56/ Tik Tok=https://www.tiktok.com/@specialneedsandmoney Brian Altounian Brian Altounian has more than 34 years of experience in the entertainment and technology industries. He has served as a C-level executive for a number of companies and has had much success helping early-stage ventures raise capital and pursue exit strategies such as acquisitions and going-public initiatives. In the entertainment industry, he has served as a Producer, Executive Producer, Co-Producer of a number of television and film projects, including COWBOYS & ALIENS, AUDREY, LOST IN WOONSOCKET, and “Random 1”. His greatest pride & joy is being a father to three children including a 27-year-old daughter who was diagnosed with Apraxia, Microcephaly and Developmental Delays at the age of 18 months, but who, despite being told all of the “normal” life experiences she would miss out on, is now married, a step mother, and a middle-school teacher (just SOME of the things that her Dr. said she would never be able to do.) Brian's second daughter is 23, graduated college with honors and is now living and working in the tech industry in Israel. Brian also has 15-year-old son who is a sophomore in high school and who was recently diagnosed with Crohn's Disease, further rooting Brian to the community of special needs and the medically complex. After entering the financial services industry over 8 years ago educating and serving families about wealth maximization and financial independence. Just over 7 years ago, he decided to focus a portion of his business on serving families with members who have special needs. As part of his service to this community, he is the co-creator and co-host of the weekly podcast “Just Two Dads.” He serves on the Board of Yes I Can Unity Through Music & Education. Facebook=https://www.facebook.com/brian.altounian Linkedin=https://www.linkedin.com/in/brianaltounian/ Instagram=https://www.instagram.com/brianaltounian/ Tik Tok=https://www.tiktok.com/@brianaltounian

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.07.527589v1?rss=1 Authors: Jaiswal, S., Sanghi, S., Singh, P. Abstract: Centriole are microtubule-based cylindrical structures characterized by their definite size, and stable, slow growing microtubules. The centriole core protein CPAP/CENPJ is known to act as a molecular cap regulating centriole length by interacting with microtubule/tubulin via the conserved microtubule destabilizing, PN2-3, and microtubule stabilizing, A5N, domains. The C-terminus of CPAP has a conserved glycine-rich G-box/TCP domain (1050-1338 amino acids). This region is involved in centriole cartwheel assembly by interacting with the cartwheel protein STIL. However, previously reported primary microcephaly mutation mapped in the G-box of CPAP, i.e., E1235V (MCPH6) affects centriole length via an unknown mechanism. Recently, another primary microcephaly mutation has been mapped to this region of CPAP, i.e., D1196N. However, the effect of D1196N on CPAP functioning is not known. We simultaneously characterized these two MCPH mutations in the G-box of CPAP. We identified that despite affecting the same domain of CPAP, they affect distinct CPAP functions at the centriole. The E1235V mutation caused an overly long centriole, and the D1196N mutation increased the centriole number. Interestingly, both these mutations affect CPAP direct interaction with the cartwheel protein STIL, which is involved in CPAP recruitment to the centriole. Accordingly, the CPAP E1235V centriole localization is significantly affected at the centriole. However, CPAP D1196N can still localize to centriole at levels comparable to the wild-type CPAP. We show that CPAP utilizes an alternate CEP152-dependent route for centriole recruitment. Importantly, our work highlights the importance of the CPAP region outside direct microtubule/tubulin interacting domains in influencing CPAP activity in cartwheel assembly and centriole length. Perhaps, this is why deleterious naturally occurring missense mutations are frequently occurring in this particular region of CPAP in primary microcephaly. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.29.520610v1?rss=1 Authors: Singh, J., Daniels, N. J., Pirozzi, F., Wynshaw-Boris, A., Lopez-Gonzalez, R., Padgett, R. A. Abstract: Mutations in the single-copy RNU4ATAC gene, which encodes U4atac snRNA of the minor spliceosome are linked to the developmental disorder microcephalic osteodysplastic primordial dwarfism type I (MOPD I). Partial loss-of-function mutations of U4atac snRNA lead to a poor prognosis, with less than three year survival. The most prominent characteristic of MOPD I is disrupted central nervous system development resulting in severe microcephaly and lissencephaly. In this study, we used self-organizing 3D cerebral organoids from patient-derived induced pluripotent stem cells (iPSCs) to investigate defective cellular events that disturb the laminar organization of the cortex and influence brain topology. We analyzed organoids from iPSCs homozygous for the partial loss-of-function U4atac snRNA 51G greater than A mutation and compared them to isogenic organoids obtained from iPSCs expressing wild-type U4atac snRNA, using immunostaining and 10X Genomics single-cell RNA sequencing. In our MOPD I organoids, we observed: a) reduced proliferation accompanied by premature neurogenesis depleting the neuro-progenitor pool due to an increased frequency of horizontal cell divisions in the ventricular zone; b) reduced numbers of intermediate progenitor and outer radial glial cells in the outer sub-ventricular zone; and c) defective radial neuronal migration, which is critical for cortical expansion in humans. Our findings therefore provide insight into MOPD I cellular pathogenesis and underline the value of these cerebral organoids as model systems for human neurodevelopmental disorders. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

What percentage of children with prenatal Zika exposure present with a congenital abnormality? Find out this and more in today's PVRoundup podcast.

What is gene therapy and how does it relate to autism? Alysson Muotri, Ph.D., contextualizes the autism spectrum, defines gene therapy, shares how human stem cells can contribute to research, and lays out how gene therapy could be used in the future. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 38387]

What is gene therapy and how does it relate to autism? Alysson Muotri, Ph.D., contextualizes the autism spectrum, defines gene therapy, shares how human stem cells can contribute to research, and lays out how gene therapy could be used in the future. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 38387]

What is gene therapy and how does it relate to autism? Alysson Muotri, Ph.D., contextualizes the autism spectrum, defines gene therapy, shares how human stem cells can contribute to research, and lays out how gene therapy could be used in the future. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 38387]

What is gene therapy and how does it relate to autism? Alysson Muotri, Ph.D., contextualizes the autism spectrum, defines gene therapy, shares how human stem cells can contribute to research, and lays out how gene therapy could be used in the future. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 38387]

What is gene therapy and how does it relate to autism? Alysson Muotri, Ph.D., contextualizes the autism spectrum, defines gene therapy, shares how human stem cells can contribute to research, and lays out how gene therapy could be used in the future. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 38387]

What is gene therapy and how does it relate to autism? Alysson Muotri, Ph.D., contextualizes the autism spectrum, defines gene therapy, shares how human stem cells can contribute to research, and lays out how gene therapy could be used in the future. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 38387]

What is gene therapy and how does it relate to autism? Alysson Muotri, Ph.D., contextualizes the autism spectrum, defines gene therapy, shares how human stem cells can contribute to research, and lays out how gene therapy could be used in the future. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 38387]

Fetal microcephaly is a devastating diagnosis. Prognosis is dependent on whether fetal microcephaly is isolated or part of other congenital anomalies. Prognosis is also directly related to the degree of fetal microcephaly. In this session, we will review the diagnostic criteria, workup, and prognosis of this devastating fetal condition.

In today's third hour, Dom welcomes Pennsylvania Republican Gubernatorial Candidate Dave White back onto the Dom Giordano Program. First, Giordano asks for White's opinion on endorsements being made for White's opponents, with White telling that politicians will always endorse politicians, explaining the benefits of electing a non-politician to office such as himself. Then, Giordano asks White to clarify his stance on abortion, telling about his son who suffers from Microcephaly, and why he firmly stands in the pro-life column. Also, White tells what separates himself from the other candidates, and tells why he is not just a regional candidate, receiving endorsements statewide. (Photo by Getty Images)

Full Hour | In today's third hour, Dom welcomes Pennsylvania Republican Gubernatorial Candidate Dave White back onto the Dom Giordano Program. First, Giordano asks for White's opinion on endorsements being made for White's opponents, with White telling that politicians will always endorse politicians, explaining the benefits of electing a non-politician to office such as himself. Then, Giordano asks White to clarify his stance on abortion, telling about his son who suffers from Microcephaly, and why he firmly stands in the pro-life column. Also, White tells what separates himself from the other candidates, and tells why he is not just a regional candidate, receiving endorsements statewide. Then, after playing Dom's Money Melody, Giordano switches back to a general conversation about Tuesday's primary election, taking calls from listeners to gauge how they're feeling in the lead up to the election?

This podcast covers an approach to children presenting with microcephaly including the definition of microcephaly, the differential diagnosis, the key points on history and physical exam to refine your differential diagnosis, and the relevant investigations and management options. It was developed by Lindsey a pediatric neurology resident in Toronto, and Dr. Claire McNiven, a pediatrics resident at the University of Alberta. The podcast's development and editing were supported by Dr. Melanie Lewis, a pediatrician at the Stollery Children's Hospital, Dr. Lauren Redgate, a pediatrician in Calgary, and Dr. Peter Gill, a pediatrician at SickKids.

Tracey checks in with her I’m a Monster post – a sad tale of “vaccine” division in families. AIDS era begins with this: Hepatitis B Foundation: History of Hepatitis B Vaccine Tdap Vaccination During Pregnancy and Microcephaly and Other Structural Birth Defects in Offspring | Congenital Defects | JAMA | JAMA Network Nothing to see here: […]

If a free-floating brain could feel pain or 'wake up,' would we know? That question was important enough for us to travel to a lab in Düsseldorf, Germany.

There was a LOT of news about the omicron variant last week. But which of it was actually important? Also, why are scientists in Germany growing thousands of miniature human brains with eyeballs on them?

Meet Rachel:It's not easy being strong in a flawed, upside down world. And when you're the parent of a special needs child, you often wonder, “Am I the only one going through these feelings?” Rachel unveils the grit and the grace behind those feelings and why it's important to lean on resources. You can follow Rachel on Instagram (@our.life.upsidedown).Welcome to Season 3 and a new format of Spur-1-On! Meet everyday women like you sharing how they reach beyond their circumstances to thrive. They share their stories, their struggles and their insights with the firm resolve to Spur-1-On!As a special gift for listening, download the Microcephaly / Epilepsy resource sheet and remember, “Words Hurt. Words Also Heal.”Tune in next time for another compelling interview to spur you on!About the Author:Connect with Doris on the following social media platforms: Facebook: @dmcushite, Instagram: @dmcushite or email: editing@doriscush.comPick up a copy of Doris' latest books, Word Twist: God's Word Imagined in New Ways and PIECES: Choosing PEACE in the Rebuilding of Our Lives (book & companion Journey Journal). Visit her Amazon.com. Author Page and don't forget to leave a review.THEME MUSIC:"Cold Funk" by Kevin MacLeod (filmmusic.io) 

In this show we discuss the common tactics of scammers and the oddity of imposing microcephaly on children.

Song Xiong is a mother of three. Song has her Bachelors in Social Work and is a case manager for Adams County in the state of Colorado. Song is also a blogger and has a Youtube/Podcast with her girlfriends called Mamas Lifestyle. The blog was inspired by Song's daughter who is a twinless twin after being diagnosed with Microcephaly and PMG.In the episode, Song shares her journey as a mother to a two year old and seven month old Everleigh May, who lost her twin Mila, at 17 weeks gestation period. We also talk about:Life with a child diagnosed with Microcephaly (small head) and Polymicrogyria (many folds in the brain).Challenges as a parent to a child with special needsHow to support a loved one who is coping with miscarriageGriefAs always, I see you, I hear you, and I value you.Love,Linda 

Brazil was among one of the countries most affected by the Zika virus in 2015 and 2016 but Dr. Carlos Pardo, a professor at Johns Hopkins University, said the virus emerged in the 1950s. Zika virus is an arbovirus — a type of virus that is transmitted by certain kinds of insects like mosquitos. The ades Aegypti mosquito, which is primarily found in tropical climates, is a known carrier of the virus. It can also be sexually transmitted. In 2015, Germana Soares, who lives in Brazil, was infected with Zika virus. Soares was 12 weeks pregnant when she became ill, but at the time, doctors believed there was no harm to the baby. In November, just before she gave birth, Soares said local news stations began reporting a link between Zika and microcephaly with women who were pregnant. Days after his birth, doctors confirmed the diagnosis; Guilherme had microcephaly. Pardo said only 20 per cent of infected people show symptoms, but the risk rests with pregnant mothers as Zika is known to also cause Congenital Zika Syndrome and microcephaly in fetuses. Microcephaly occurs in these children when their mothers are infected with Zika while pregnant, he said. The fetus develops viral illness and eventually encephalitis. The World Health Organization estimated at the height of the epidemic, there were over 216,207 probable cases of acute Zika virus disease reported in Brazil, and thousands of babies were born with complications. Anis Institute for Bioethics, a not-for-profit organization in Brazil, has been one of the leading organizations advocating for women and families affected by the Zika epidemic. Luciana Brito, researcher and psychologist for Anis Institute for Bioethics, said since the beginning of the epidemic, over 19,000 babies have been born with suspected Congenital Zika Syndrome. On this episode of What Happened To…?, Erica Vella revisits the 2015 Zika epidemic and finds out if the virus is still a threat. She also speaks with the families impacted virus who share what life has been like. Contact: Twitter: @ericavella Email: erica.vella@globalnews.ca See omnystudio.com/listener for privacy information.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.29.318527v1?rss=1 Authors: Martins, S., Erichsen, L., Datsi, A., Wruck, W., Goering, W., Chrzanowska, K., Adjaye, J. Abstract: Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive genetic disorder caused by mutations within NBN, a DNA-damage repair protein. Hallmarks of NBS include several clinical manifestations such growth retardation, chromosomal instability, immunodeficiency and progressive microcephaly. However, the etiology of microcephaly in NBS patients remains elusive. Here, we employed induced pluripotent stem cell-derived brain organoids from two NBS patients to analyze the underlying mechanisms of microcephaly. We show that NBS-organoids carrying the homozygous 647del5 NBN mutation are significantly smaller in size with disrupted cyto-architecture Patient-derived organoids exhibit premature differentiation together with neuronatin (NNAT) overexpression and key pathways related to DNA damage response and cell cycle are differentially regulated compared to controls. Moreover, we show that after exposure to bleomycin, NBS organoids undergo a delayed p53-mediated DNA damage response and aberrant trans-synaptic signalling, which ultimately leads to neuronal apoptosis. Our data provide insights into how mutations within NBN alters neurogenesis in NBS patients, thus providing a proof of concept that cerebral organoids are a valuable tool for studying DNA damage-related disorders. Copy rights belong to original authors. Visit the link for more info

Meet Shelly Simon and Riley Lee and learn all about Riley’s daughter Ryann. Ryann is medically complicated with many diagnoses, such as Turner syndrome, Microcephaly, Cerebral Palsy, heart and brain defects, Atypical Autism with ADHD/OCD, hearing loss, and many more. Follow us on social media @pleaseexcuseourissuespodcast and @hopesseed

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.17.254037v1?rss=1 Authors: Carpentieri, J. A., Di Cicco, A., Andreau, D., Del Maestro, L., El Marjou, F., Coquand, l., Brault, J.-B., Bahi-Buisson, N., Baffet, A. Abstract: Primary microcephaly and megalencephaly are severe brain malformations defined by reduced and increased brain size, respectively. Whether these two pathologies arise from related alterations at the molecular level is unclear. Microcephaly has been largely associated with centrosomal defects, leading to cell death. Here, we investigated the consequences of WDR81 loss of function, which cause severe microcephaly in patients. We show that WDR81 regulates endosomal trafficking of EGFR, and that loss of function leads to reduced MAP kinase pathway activation. Mouse radial glial progenitor cells knocked-out for WDR81 display reduced proliferation rates, leading to reduced brain size. These proliferation defects are rescued in vivo by the expression of megalencephaly-causing mutated Cyclin D2. Our results identify the endosomal machinery as an important regulator of RG cell proliferation rates and brain growth. They demonstrate that microcephaly and megalencephaly can be due to opposite effects on the proliferation rate of radial glial progenitors. Copy rights belong to original authors. Visit the link for more info

The conclusion of my conversation with Jack Bradley, Andrew Barger, Brent Baisley and Liam Doyle

Halle's story, as told by mom, Nikole, about life and love in the town of Microcephaly. Continue reading →

TWiV minus one reveals delayed neurological deficits in children without microcephaly born to Zika virus infected mothers, and N-glycolyl-neuraminic acid as a receptor for influenza A viruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Deficits in children born to Zika virus infected mothers (Nat Med) Zika virus is still a threat (NY Times) N-glycolyl-neuraminic acid as influenza virus receptor (Cell Rep) Letters read on TWiV 556 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Foldable viral capsid models and Foldable models demonstrate T numbers Alan - Laws Guide to Nature Drawing and Journaling Dickson- NASA 50th Events Kathy- Alta Obscura’s 17,069 strange and wonderful places Vincent- TWiEVO 44: The enemy of my enemy is my phage Listener Picks Anthony - Global Water Pathogen Project Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

TWiV minus one reveals delayed neurological deficits in children without microcephaly born to Zika virus infected mothers, and N-glycolyl-neuraminic acid as a receptor for influenza A viruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Deficits in children born to Zika virus infected mothers (Nat Med) Zika virus is still a threat (NY Times) N-glycolyl-neuraminic acid as influenza virus receptor (Cell Rep) Letters read on TWiV 556 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Foldable viral capsid models and Foldable models demonstrate T numbers Alan - Laws Guide to Nature Drawing and Journaling Dickson- NASA 50th Events Kathy- Alta Obscura’s 17,069 strange and wonderful places Vincent- TWiEVO 44: The enemy of my enemy is my phage Listener Picks Anthony - Global Water Pathogen Project Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The World Health Organization has declared an emergency over the outbreak of Zika in Latin America. But is the increase in birth defects in Brazil caused by the virus or something else -- and why won't Brazil share any of the data it's collecting?

The dangerous and rapidly spreading Zika virus is our top science story this week. It is believed responsible for thousands of birth defects in Brazil, where authorities are deploying genetically modified mosquitoes to slow the outbreak. Also: A company in Florida claims it's invented a new type of telescope that can see antimatter -- and they may be invisible entities conducting "unauthorized surveillance" over "sensitive areas".