Podcast appearances and mentions of Andrew Hughes

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Best podcasts about Andrew Hughes

Latest podcast episodes about Andrew Hughes

Mornings with Neil Mitchell
When was Anthony Albanese the 'most stressed' during the election campaign?

Mornings with Neil Mitchell

Play Episode Listen Later May 3, 2025 5:39


Political marketing expert Dr Andrew Hughes joined Tom Elliott on election night. See omnystudio.com/listener for privacy information.

Drive With Tom Elliott
Political marketing expert weighs in on new 'diss track' by the Liberal Party

Drive With Tom Elliott

Play Episode Listen Later Apr 14, 2025 7:03


Political marketing expert at the Australian National University, Dr Andrew Hughes, thinks the song is a smart political move by the Liberal Party.See omnystudio.com/listener for privacy information.

Mornings with Neil Mitchell
The popular Melbourne pubs which won't be celebrating Australia Day

Mornings with Neil Mitchell

Play Episode Listen Later Dec 1, 2024 6:19


Tom Elliott has revealed some of the popular pubs in Melbourne which won't be celebrating or acknowledging Australia Day next month. The 3AW Mornings host also spoke with political marketing expert Dr Andrew Hughes on pub group Australian Venue Co. and their controversial decision to ban Australia Day celebrations. See omnystudio.com/listener for privacy information.

Afternoons with Deborah Knight
Why have some legacy brands collapsed while others continue to flourish

Afternoons with Deborah Knight

Play Episode Listen Later Sep 20, 2024 9:33


Michael McLaren has enlisted the help of marketing expert Andrew Hughes at the Australian National University to discuss why Tupperware has collasped.See omnystudio.com/listener for privacy information.

The Tubi Tuesdays Podcast
The Tubi Tuesdays Podcast Episode 159 - The Golden Bat aka Golden Ninja (1966)

The Tubi Tuesdays Podcast

Play Episode Listen Later Aug 26, 2024 88:56


Welcome to our podcast series from The Super Network and Pop4D called Tubi Tuesdays Podcast! This podcast series is focused on discovering and doing commentaries/watch a longs for films found on the free streaming service Tubi, at TubiTV Your hosts for Tubi Tuesdays are Super Marcey, ‘The Terrible Australian' Bede Jermyn, Prof. Batch (From Pop4D & Web Tales: A Spider-Man Podcast) and Kollin (From Trash Panda Podcast), will take turns each week picking a film to watch and most of them will be ones we haven't seen before.Movie Starts Playing At: 00:09:59Welcome back to The Tubi Tuesdays Podcast, the number one Tubi related podcast that's hosted by two Australians, one Canadian and one American! All four hosts are indeed here (for the most part) with Super Marcey, Bede Jermyn, Prof. Batch and Kollin! This week is Bede's pick, however his choice of film isn't a terrible one and it's one that Marcey also really enjoys with The Golden Bat aka Golden Ninja (1966)! For some reason the film goes by the title Golden Ninja on Tubi, but it is best known as The Golden Bat or Ôgon batto. The character of The Golden Bat may actually be the first comicbook superhero predating Superman, he may actually be the most fashion hero as well. Enjoy the show!The Golden Bat aka Golden Ninja was directed by Hajime Satô, it stars Sonny Chiba, Andrew Hughes, Wataru Yamagawa, Hisako Tsukuba, Emily Takami, Kôji Sekiyama and Kôsaku Okano.If you have never listened to a commentary before and want to watch the film along with the podcast, here is how it works. You simply need to grab a copy of the film or load it up on Tubi (you may need alcohol), and sync up the podcast audio with the film. We will tell you when to press and you follow along, it is that easy! Because we have watched the films on Tubi, it is a free service and there are ads, however we will give a warning when it comes up, so you can pause the film and provide time stamps to keep in sync.Highlights Include:* Phew Marcey is back!* Kollin's up and down due to the kids!* Gotta love that The Golden Bat dresses like Skeletor and Liberace!* Is there more unofficial product placement this episode?* Did you acknowledge your Tribal Kief today?* Look we really couldn't tell ya what's happening in this film!* The film is on the cheap side but quite a lot of fun!* Plus much, much more!Check out The Super Network on Patreon to gain early access to The Tubi Tuesdays Podcast!DISCLAIMER: This audio commentary isn't meant to be taken seriously, it is just a humourous look at a film. It is for entertainment purposes, we do not wish to offend anyone who worked on and in the film, we have respect for you all. Hosted on Acast. See acast.com/privacy for more information.

Inside Books
Inside Books Episode 111 Andrew Hughes

Inside Books

Play Episode Listen Later Aug 26, 2024 35:21


Inside Books is a regular popular author interview podcast presented by Breda Brown. In this episode Breda is in conversation with archivist, historian and novelist Andrew Hughes.

Drive
Does Free-to-Air TV Really Need Gambling Ads to Survive?

Drive

Play Episode Listen Later Aug 20, 2024 25:35


TV stations claim they would face financial collapse if the government bans gambling advertising. Is this the case? David Barr talks to Andrew Hughes from ANU who disputes this.  [...]Read More... from Does Free-to-Air TV Really Need Gambling Ads to Survive?

We Do This For Fun
Highest Tea, Highest Paddle Board, High Regard: World Records with Andrew Hughes

We Do This For Fun

Play Episode Listen Later Apr 22, 2024 0:47


Meet Andrew Hughes, a very cool guy. Andrew is an explorer and seasoned mountaineer, renowned not only for expeditions, but for his charm. How many people propose from Mount Everest (the internet says he was only the second)?His resume reads like a true adventurer. He's completed the Seven Summits (highest mountains on each continent), six of the Seven Volcanic Summits (highest volcanoes on each continent) and the Antarctica Trifecta consecutively Skiing the Last Degree to the South Pole and reaching the summits of Mount Vinson (the highest mountain) and Mount Sidley (the highest volcano) in Antarctica.Andrew doesn't stop at personal milestones, he holds multiple world records. He orchestrated the 'World's Highest Tea Party' atop Mount Everest (again, charming). And most recently, he paddle boarded on the highest flatwater lake, located at Tres Cruces Norte in Chile.Beyond the records and feats of strength, Andrew infuses purpose into his adventures. Each expedition serves as a platform to raise awareness about pressing issues like climate change. In fact, his latest endeavor nearly faced cancellation due to dwindling water levels—a stark reminder of the environmental challenges we face.As we celebrate Earth Day 2024, let Andrew be your inspiration to forge a deeper connection with the natural world. He not only inspires awe but also underscores the importance of cherishing and safeguarding our planet.@andrew_i_hughes

Oliver Callan
Andrew Hughe's novel Emma Disappeared

Oliver Callan

Play Episode Listen Later Apr 8, 2024 16:59


Andrew Hughes new book Emma Disappeared is a gripping crime novel. His last book The Coroners' Daughter was named as the One Dublin One Book title for 2023.

Playback Daily
Playback Daily Podcast Monday 8 April 2024

Playback Daily

Play Episode Listen Later Apr 8, 2024 57:40


Goodbye Leo, hello Simon; From archivist to author – Andrew Hughes on his new novel; And is middle-aged spread genetic?

The Rock Fight: Outdoor Industry & Adventure Commentary
Merrell Plays The Lifestyle Card, Seattle Cougar Attack & A Rescue On Mount Washington

The Rock Fight: Outdoor Industry & Adventure Commentary

Play Episode Listen Later Feb 24, 2024 33:38


Today on THE ROCK FIGHT (an outdoor podcast that aims for the head) Colin and Justin Housman celebrate Justin's one year Rock-aversary by running through the headlines!The two hit the following news stories to come out of the outdoor community and industry this past week:A cougar attacked 5 cyclists just east of Seattle (07:18)Wolverine CEO announces that Merrell and Saucony will both pursue expanding their lifestyle offerings (13:39)Andrew Hughes sets altitude SUP record in the Andes (21:42)Unprepared hiker rescued from Mount Washington in 90+ mph winds (24:00)All of this after America's favorite podcast segment, What Is Justin Doing This Weekend?!Please follow and subscribe to THE ROCK FIGHT and give us a 5 star rating wherever you get your podcasts.Have a question or comment for a future mailbag episode? Send it to myrockfight@gmail.com or send a message on Instagram or Threads.Subscribe to Adventure Journal to get more Justin Housman in your life.Check out Long Weekend Coffee for the best cup of coffee for your next adventure. Be sure to enter promo code 'rock10' at checkout to receive 10% off of your first order. Subscribe to Kyle Frost's Here and There and click here to subscribe to Mountain Gazette.Thanks for listening! THE ROCK FIGHT is a production of Rock Fight, LLC.

3AW Afternoons with Dee Dee
Marketing experts weighs in on Woolworths not selling Australia Day merch

3AW Afternoons with Dee Dee

Play Episode Listen Later Jan 12, 2024 6:39


Marketing expert Andrew Hughes joined Grubby on 3AW Afternoons. See omnystudio.com/listener for privacy information.

Preston North End Weekly
PNE Press: Middlesbrough (A)

Preston North End Weekly

Play Episode Listen Later Nov 29, 2023 6:02


Preston North End are thrashed 4-0 at Middlesbrough... listen to the post-match thoughts of manager Ryan Lowe and Andrew Hughes. Hosted on Acast. See acast.com/privacy for more information.

Soma Northwest Podcast
I am the bread of life - John 6:35-40

Soma Northwest Podcast

Play Episode Listen Later Nov 26, 2023 30:22


Tall Tale TV
"Queen of the Desert" - SciFi Short Story - by Andrew Hughes

Tall Tale TV

Play Episode Listen Later Sep 29, 2023 21:52


Queen of the Desert ep.652 Nothing deserves captivity. Andrew Hughes has been writing and publishing short stories for the past decade. They have appeared in numerous magazines and anthologies, including Penumbric and on the No Sleep Podcast. His fantasy novella, Children of the Arc, was published in 2023 by TWB Press. He currently lives in Arizona, working as a middle school English teacher, and mediating heated debates between his roommates, a Maine Coon cat and the world's most rambunctious husky. Novella by Andrew Hughes: https://amzn.to/3qIVFrx More TTTV stories by Andrew Hughes: https://talltaletv.com/tag/andrew-hughes/ ---- Listen Elsewhere ---- YouTube:  https://www.youtube.com/c/TallTaleTV Website: http://www.TallTaleTV.com   ---- Story Submission ---- Got a short story you'd like to submit? Submission guidelines can be found at http://www.TallTaleTV.com   ---- About Tall Tale TV ---- Hi there! My name is Chris Herron and I'm an audiobook narrator. In 2015, I suffered from poor Type 1 diabetes control which lead me to become legally blind for almost a year. The doctors didn't give me much hope, predicting an 80% chance that I would never see again. But I refused to give up and changed my lifestyle drastically. Through sheer willpower (and an amazing eye surgeon) I beat the odds and regained my vision. During that difficult time, I couldn't read or write, which was devastating as they had always been a source of comfort for me since childhood. However, my wife took me to the local library where she read out the titles of audiobooks to me. I selected some of my favorite books, such as the Disc World series, Name of the Wind, Harry Potter, and more, and the audiobooks brought these stories to life in a way I had never experienced before. They helped me through the darkest period of my life and I fell in love with audiobooks. Once I regained my vision, I decided to pursue a career as an audiobook narrator instead of a writer. That's why I created Tall Tale TV, to support aspiring authors in the writing communities that I had grown to love before my ordeal. My goal was to help them promote their work by providing a promotional audio short story that showcases their writing skills to readers. They say the strongest form of advertising is word of mouth, so I offer a platform for readers to share these videos and help spread the word about these talented writers. Please consider sharing these stories with your friends and family to support these amazing authors. Thank you!   ---- legal ---- All stories on Tall Tale TV have been submitted in accordance with the terms of service provided on http://www.talltaletv.com or obtained with permission by the author. All images used on Tall Tale TV are either original or Royalty and Attribution free. Most stock images used are provided by http://www.pixabay.com , https://www.canstockphoto.com/ or created using AI. Image attribution will be declared only when required by the copyright owner. Common Affiliates are: Amazon, Smashwords

Tall Tale TV
"Risen" - Fantasy Short Story - by Andrew Hughes

Tall Tale TV

Play Episode Listen Later Aug 25, 2023 10:42


Risen ep.647 War is the same everywhere, only the soldiers change. Andrew has been writing and publishing short stories for the past decade. They have appeared in numerous magazines and anthologies, including Penumbric and on the No Sleep Podcast. His fantasy novella, Children of the Arc, was published in 2023 by TWB Press. He currently lives in Arizona, working as a middle school English teacher, and mediating heated debates between his roommates, a Maine Coon cat and the world's most rambunctious husky. Novella by Andrew Hughes: https://amzn.to/3qIVFrx   ---- Listen Elsewhere ---- YouTube:  https://www.youtube.com/c/TallTaleTV Website: http://www.TallTaleTV.com   ---- Story Submission ---- Got a short story you'd like to submit? Submission guidelines can be found at http://www.TallTaleTV.com   ---- About Tall Tale TV ---- Hi there! My name is Chris Herron and I'm an audiobook narrator. In 2015, I suffered from poor Type 1 diabetes control which lead me to become legally blind for almost a year. The doctors didn't give me much hope, predicting an 80% chance that I would never see again. But I refused to give up and changed my lifestyle drastically. Through sheer willpower (and an amazing eye surgeon) I beat the odds and regained my vision. During that difficult time, I couldn't read or write, which was devastating as they had always been a source of comfort for me since childhood. However, my wife took me to the local library where she read out the titles of audiobooks to me. I selected some of my favorite books, such as the Disc World series, Name of the Wind, Harry Potter, and more, and the audiobooks brought these stories to life in a way I had never experienced before. They helped me through the darkest period of my life and I fell in love with audiobooks. Once I regained my vision, I decided to pursue a career as an audiobook narrator instead of a writer. That's why I created Tall Tale TV, to support aspiring authors in the writing communities that I had grown to love before my ordeal. My goal was to help them promote their work by providing a promotional audio short story that showcases their writing skills to readers. They say the strongest form of advertising is word of mouth, so I offer a platform for readers to share these videos and help spread the word about these talented writers. Please consider sharing these stories with your friends and family to support these amazing authors. Thank you!   ---- legal ---- All stories on Tall Tale TV have been submitted in accordance with the terms of service provided on http://www.talltaletv.com or obtained with permission by the author. All images used on Tall Tale TV are either original or Royalty and Attribution free. Most stock images used are provided by http://www.pixabay.com , https://www.canstockphoto.com/ or created using AI. Image attribution will be declared only when required by the copyright owner. Common Affiliates are: Amazon, Smashwords    

Kaidankai: Ghost and Supernatural Stories
3rd place contest winner: Old Richard by Andrew Hughes

Kaidankai: Ghost and Supernatural Stories

Play Episode Listen Later Aug 9, 2023 20:00


A child is tormented by the dying screams of his friends and sister after they entered a haunted house that he was too afraid to enter. Yet he returns to the scene as a young man. For what purpose? Andrew Hughes has been writing for the past decade. His short stories have appeared in Sanitarium Magazine, Sinister Smile Press anthologies, and on the No Sleep Podcast. His fantasy novella, Children of the Arc, was published in 2023 by TWB Press. He currently lives in Arizona, working as a middle school English teacher, and mediating heated debates between his roommates, a Maine Coon cat and the world's most rambunctious husky. You can read "Old Richard" at https://www.kaidankaistories.com.Website: kaidankaistories.comFollow us on: TwitterInstagramFacebook

Drive With Tom Elliott
The 'only reason' a state politician should travel overseas on the taxpayer dime

Drive With Tom Elliott

Play Episode Listen Later Jul 17, 2023 4:02


Dr Andrew Hughes is a political marketing guru and said there was only one reason a state politician should travel overseas on the taxpayer dime.See omnystudio.com/listener for privacy information.

Flying Midwest Podcast
Episode 36: WTF is METAR AF - with creators Bryan Turner and Andrew Hughes

Flying Midwest Podcast

Play Episode Listen Later Jul 3, 2023 57:58


We welcome the funniest game in aviation weather, METAR AF! This new aviation weather app gives you the latest METAR data for your local airport, with a comedic twist. Creators Bryan Turner and Andrew Hughes talk to us about the creation of the app and what they are working on for the future! www.metaraf.com https://apps.apple.com/us/app/metar-af/id1661162042 https://play.google.com/store/apps/details?id=com.hugheswd.metaraf&hl=en&gl=US&pli=1 https://humanelycoded.com/ Youtube @justplanesilly Free content isn't always free. Each month, we have various costs associated with brining you the podcast. If you would like to help us financially, you can purchase our Merch, check out some great gear from Lightspeed and Flying Eyes at our affiliate links, or become a member of our Patreon community. We have a ton of great merch in our merch store just in time for summer. On our Patreon we will have exclusive interview content, This Week in Aviation History, Jim's attempt at blogging with his CFI Quest, and a look at Madi's old blog from her early days in aviation. We hope you consider supporting us and becoming a patron. Check out our Patreon Community: ⁠⁠⁠⁠⁠https://www.patreon.com/Flyingmidwestpodcast⁠⁠⁠⁠⁠ Check them Lightspeed Headsets at our affiliate page. ⁠https://www.lightspeedaviation.com/?campaign=flyingmidwest23&ref=101⁠ Merch: ⁠⁠⁠⁠⁠⁠www.flyingmidwest.com/merch⁠⁠⁠⁠⁠⁠ Summer Merch Discount code gets you 15% off - Summer23 We are thrilled to announce another partnership with Flying Eyes Optics. They design sunglasses and eyewear for pilots, by pilots. Go check out all of their great line of products at out affiliate page. If you like what you see, use coupon code "FlyingMidwest10" and get 10% off your purchase. Flying Eyes - ⁠⁠⁠⁠https://flyingeyesoptics.com/?ref=Flyingmidwest23⁠⁠⁠ Be sure to follow us and subscribe on social media, and leave us a review wherever you find our podcast. Website: ⁠⁠⁠⁠⁠www.flyingmidwest.com⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠www.facebook.com/flyingmidwestpodcast⁠⁠⁠⁠⁠ Linktree: ⁠⁠⁠⁠⁠linktr.ee/flyingmidwestpodcast⁠⁠⁠⁠⁠ Email: ⁠⁠⁠⁠⁠Flyingmidwestpodcast@gmail.com⁠⁠⁠⁠⁠

Seeking the Extraordinary
Andrew Hughes: More Than Mountains

Seeking the Extraordinary

Play Episode Listen Later May 16, 2023 50:57


Andrew Hughes not only has climbed the seven summits, but also six of the seven volcanic summits, the highest volcanoes on each continent. He also became the fastest and first American man and third person ever to complete the Antarctica trifecta. He practices turning discomfort and challenge into growth and gratitude. But he does this all with a greater purpose; to make meaningful impacts in the world. What motivates Andrew to “seek beyond the summit”? Listen now.

Discover CircRes
March 2023 Discover CircRes

Discover CircRes

Play Episode Listen Later Mar 16, 2023 34:33


This month on Episode 46 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the March 3 and March 17th issues of Circulation Research. This episode also features an interview with Dr Andrew Hughes and Dr Jessilyn Dunn about their review, Wearable Devices in Cardiovascular Medicine.   Article highlights:   Delgobo, et al. Deep Phenotyping Heart-Specific Tregs   Sun, et al. Inhibition of Fap Promotes Cardiac Repair After MI   Sun, et al. Endosomal PI3Kγ Regulates Hypoxia Sensing   Johnson, et al. Hypoxemia Induces Minimal Cardiomyocyte Division   Cindy St. Hilaire:        Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's Journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to share four articles selected from the March 3rd and March 17th issues of CircRes. I'm also going to have a discussion with Dr Andrew Hughes and Dr Jessilyn Dunn about their review, Wearable Devices in Cardiovascular Medicine. And the Review is also featured in our March 3rd issue.   Cindy St. Hilaire:        First, the highlights. The first article I'm going to present is Myocardial Milieu Favors Local Differentiation of Regulatory T-Cells. The first author is Murilo Delgobo and the corresponding author is Gustavo Campos Ramos. After myocardial infarction, the release of autoantigens from the damaged heart cells activates local and infiltrating immune cells such as the T-cell. Studies in mice have shown that fragments of the muscle protein myosin can act as autoantigens, and these myosin fragments are the dominant driver of the T-cell response.   But how do these myosin specific T-cells behave in the damaged heart to drive inflammation and repair is unknown. To find out, Delgobo and colleagues studied endogenous myosin specific T-cells, as well as those transferred into recipient mice. They found, whether exogenously supplied or endogenously created, the myosin specific T-cells that accumulated in the animals' infarcted hearts tended to adopt an immunosuppressive T-regulatory phenotype.   Strikingly, even if the exogenous cells were differentiated into inflammatory TH-17 cells prior to transfer, a significant proportion of them were still reprogrammed into T-regs within the heart. Although cells pre-differentiated into an inflammatory TH-17 phenotype were less inclined to change after the transfer, the results nevertheless indicate that, by and large, the infarcted heart promotes T-cell reprogramming to quell inflammation and drive repair. Yet exactly how the heart does this is a question for future studies.   Cindy St. Hilaire:        The next article I'm going to present is titled Inhibition of FAP Promotes Cardiac Repair by Stabilizing BNP. The first authors of the study are Yuxi Sun and Mengqiu Ma, and the corresponding author is Rui Yue, and they are from Tongji University. After myocardial infarction, there needs to be a balance of recovery processes to protect the tissue. Fibrosis, for example, acts like an immediate bandaid to hold the damaged heart muscle together, but fibrosis can limit contractile function.   Similarly, angiogenesis and sufficient revascularization is required to promote survival of cardiomyocytes within the ischemic tissue and protect heart function. To better understand the balance between fibrotic and angiogenic responses, Sun and colleagues examined the role of fibroblasts activated protein, or FAP, which is dramatically upregulated in damaged hearts, and brain natriuretic peptide, or BNP, which promotes angiogenesis in the heart.   In this study, they found that genetic deletion or pharmacological inhibition of FAP in mice reduces cardiac fibrosis and improves angiogenesis and heart function after MI. Such benefits are not seen if BNP or its receptor, NRP-1, are lacking. The in vitro experiments revealed that FAP's protease activity degrades BNP, thus inhibiting the latter's angiogenic activity. Interestingly, while FAP is upregulated in the heart, its levels drop in the blood, showing that BNP inhibition is localized. Together, these results suggest that blocking FAP's activity in the heart after MI could be a possible strategy for protecting the muscle's function.   Cindy St. Hilaire:        The next article I want to present is Hypoxia Sensing of Beta-Adrenergic Receptor is Regulated by Endosomal PI-3 Kinase Gamma. The first author of this study is Yu Sun, and the corresponding author is Sathyamangla Naga Prasad. Hypoxia is the most proximate acute stress encountered by the heart during an ischemic event. Hypoxia triggers dysfunction of the beta-adrenergic receptors, beta-1AR and beta-2AR, which are critical regulators of cardiac function.   Under normoxic conditions, activation of PI3K-gamma by beta-adrenergic receptors leads to feedback regulation of the receptor by hindering its dephosphorylation through inhibition of protein phosphatase 2A or PP2A. Although it is known that ischemia reduces beta-adrenergic receptor function, the impact of hypoxia on interfering with this PI3K feedback loop was unknown.   Using in vitro and in vivo techniques, this group found that activation of PI3K-gamma underlies hypoxia sensing mechanisms in the heart. Exposing PI3K-gamma knockout mice to acute hypoxia resulted in preserved cardiac function and reduced beta-adrenergic receptor phosphorylation. And this was due to a normalized beta-2AR associated PP2A activity, thus uncovering a unique role for PI3K-gamma in hypoxia sensing and cardiac function.   Similarly, challenging wild-type mice post hypoxia with dobutamine resulted in an impaired cardiac response that was normalized in the PI3K-gamma knockout mice. These data suggests that preserving beta-adrenergic resensitization by targeting the PI3K-gamma pathway would maintain beta-adrenergic signaling and cardiac function, thereby permitting the heart to meet the metabolic demands of the body following ischemia.   Cindy St. Hilaire:        The last article I want to highlight is Systemic Hypoxia Induces Cardiomyocyte Hypertrophy and Right Ventricle Specific Induction of Proliferation. First author of this study is Jaslyn Johnson, and the corresponding author is Steven Houser, and they're at Temple University.   The cardiac hypoxia created by myocardial infarction leads to the death of the heart tissue, including the cardiomyocytes. While some procedures such as reperfusion therapy prevent some cardiomyocyte death, true repair of the infarcted heart requires that dead cells be replaced. There have been many studies that have attempted new approaches to repopulate the heart with new myocytes. However, these approaches have had only marginal success.   A recent study suggested that systemic hypoxemia in adult male mice could induce cardiac monocytes to proliferate. Building on this observation, Johnson and colleagues wanted to identify the mechanisms that induced adult cardiomyocyte cell cycle reentry and wanted to determine whether this hypoxemia could also induce cardiomyocyte proliferation in female mice.   Mice were kept in hypoxic conditions for two weeks, and using methods to trace cell proliferation in-vivo, the group found that hypoxia induced cardiac hypertrophy in both the left ventricle and the right ventricle in the myocytes of the left ventricle and of the right ventricle. However, the left ventricle monocytes lengthened while the RV monocytes widened and lengthened.   Hypoxia induced an increase in the number of right ventricular cardiomyocytes, but did not affect left ventricular monocyte proliferation in male or in female mice. RNA sequencing showed upregulation of cell cycle genes which promote the G1 to S phase transition in hypoxic mice, as well as a downregulation of cullen genes, which are the scaffold proteins related to the ubiquitin ligase complexes. There was significant proliferation of non monocytes in mild cardiac fibrosis in the hypoxic mice that did not disrupt cardiac function.   Male and female mice exhibited similar gene expression patterns following hypoxia. Thus, systemic hypoxia induced a global hypertrophic stress response that was associated with increased RV proliferation, while LV monocytes did not show increased proliferation. These results confirm previous reports that hypoxia can induce cardiomyocyte cell cycle activity in-vivo, and also show that this hypoxia induced proliferation also occurs in the female mice.   Cindy St. Hilaire:        With me today for our interview, I have Dr Andrew Hughes and Dr Jessilyn Dunn, and they're from Vanderbilt University Medical Center. And they're here to discuss the review article that they helped co-author called Wearable Devices in Cardiovascular Medicine. And just as a side note, the corresponding author, Evan Brittain, unfortunately just wasn't able to join us due to clinical service, but they're going to help dissect and discuss this Review with us. Thank you both so much for joining me today. Andy, can you just tell us a little bit about yourself?   Andy Hughes:             Yeah, thank you, Cindy. I'm Andy Hughes. I'm a third year medicine resident at Vanderbilt University who is currently on an NIH supported research year this year. And then will be applying to cardiology fellowships coming up in the upcoming cycle.   Cindy St. Hilaire:        Great, thank you. And Jessilyn, I said you are from Vanderbilt. I know you're from Duke. It was Evan and Andy at Vanderbilt. Jessilyn, tell us about yourself.   Jessilyn Dunn:             Thanks. I am an Assistant Professor at Duke. I have a joint appointment between biomedical engineering and biostatistics and bioinformatics. The work that my lab does is mainly centered on digital health technologies in developing what we call digital biomarkers, using data from often consumer wearables to try to detect early signs of health abnormalities and ultimately try to develop interventions.   Cindy St. Hilaire:        Thank you. We're talking about wearable devices today, and obviously the first thing I think most of us think about are the watch-like ones, the ones you wear on your wrists. But there's really a whole lot more out there. It's not just Apple Watches and Fitbits and the like. Can you just give us a quick summary of all these different types of devices and how they're classified?   Jessilyn Dunn:             Yeah, absolutely. We have a wide variety of different sensors that can be useful. A lot of times, we like to think about them in terms of the types of properties that they measure. So mechanical properties like movement, electrical properties like electrical activity of the heart. We have optical sensors. And so, a lot of the common consumer wearables that we think about contain these different types of sensors.   A good example that we can think about is your consumer smartwatch, like an Apple Watch or a Fitbit or a Garmin device where it has something called an accelerometer that can measure movement. And oftentimes, that gets converted into step counts. And then it may also have an optical sensor that can be used to measure heart rate in a particular method called PPG, or photoplethysmography. And then some of the newer devices also have the ability to take an ECG, so you can actually measure electrical activity as well as the optical based PPG heart rate measurement. These are some of the simpler components that make up the more complex devices that we call wearables.   Cindy St. Hilaire:        And how accurate are the measurements? You did mention three of the companies, and I know there's probably even more, and there's also the clinical grade at-home ECG machines versus the one in the smartwatch. How accurate are the measurements between companies? And we also hear recent stories about somebody's Apple Watch calling 911 because they think they're dead, things like that. Obviously, there's proprietary information involved, but how accurate are these devices and how accurate are they between each other?   Jessilyn Dunn:             This is a really interesting question and we've done quite a bit of work in my lab on this very topic, all the way from what does it mean for something to be accurate? Because we might say, "Well, the more accurate, the better," but then we can start to think about, "Well, how accurate do we need something to be in order to make a clinical decision based off of that?" And if it costs significantly more to make a device super, super accurate, but we don't need it to be that accurate to make useful decisions, then it actually might not be serving people well to try to get it to that extreme level of accuracy.   So there are a lot of trade-offs, and I think that's a tough thing to think about in the circumstances, is these trade-offs between the accuracy and, I don't know, the generalizability or being able to apply this to a lot of people. That being said, it also depends on the circumstances of use. When we think about something like step counts, for example, if you're off by a hundred step counts and you're just trying to get a general view of your step counts, it's not that much of a problem.   But if we're talking about trying to detect an irregular heart rhythm, it can be very bad to either miss something that's abnormal or to call something abnormal that's not and have people worried. We've been working with the Digital Medicine Society to develop this framework that we call V3, which is verification, analytic validation and clinical validation. And these are the different levels of analysis or evaluation that you can do on these devices to determine how fit for purpose are they.   Given the population we're trying to measure in and given what the goal of the measurement is, does the device do the job? And what's also interesting about this topic is that the FDA has been evolving how they think about these types of devices because there's, in the past, been this very clear distinction between wellness devices and medical devices. But the problem is that a lot of these devices blur that line. And so, I think we're going to see more changes in the way that the FDA is overseeing and potentially regulating things like this as well.   Cindy St. Hilaire:        These consumer-based devices have started early on as the step counters. When did they start to bridge into the medical sphere? When did that start to peak the interest of clinicians and researchers?   Jessilyn Dunn:             Yeah, sure. What's interesting is if we think back to accelerometers, these have been used prior to the existence of mobile phones. These really are mechanical sensors that could be used to count steps. And when we think about the smartwatch in the form that we most commonly think of today, probably looking back to about 2014 is when ... maybe between 2012, 2014 is when we saw these devices really hitting the market more ... Timing for when the devices that we know as our typical consumer smartwatch today was around 2012 to 2014.   And those were things that were counting steps and then the next generation of that added in the PPG or photoplethysmography sensor. That's that green light when we look on the back of our watch that measures heart rate. And so, thinking back to the early days, probably Jawbone, there was a watch called Basis, the Intel Basis watch. Well, it was Basis and then got acquired by Intel. Fitbit was also an early joining the market, but that was really the timing.   Cindy St. Hilaire:        How good are these devices at actually changing behavior? We know we're really good at tracking our steps now and maybe monitoring our heartbeat or our oxygen levels. How good are they at changing behavior though? Do we know yet?   Andy Hughes:             Yeah, that's a great question and certainly a significant area of ongoing research right now with physical activity interventions. Things that we've seen right now is that simple interventions that use the wearable devices alone may not be as effective as multifaceted interventions. And what I mean by that is interventions that use the smartwatch but may be coupled with another component, whether that is health education or counseling or more complex interventions that use gamification or just in time adaptive interventions.   And gamification really takes things to another level because that integrates components, competition or support or collaboration and really helps to build upon features of behaviors that we know have an increased likelihood of sustaining activity. With that being said, that is one of the challenges of physical activity interventions, is the sustainability of their improvements over the course of months to years.   And something that we have seen is the effects do typically decrease over time, but there is work on how do we integrate all of these features to develop interventions that can help to sustain the results more effectively. So we have seen some improvement, but finding ways to sustain the effects of physical activity is certainly an area of ongoing research.   Cindy St. Hilaire:        I know it's funny that even as adults we love getting those gold stars or the circle completions. All of these devices, whether it's smartwatches like we're just talking about, or the other things for cardiac rehabilitation, they're generating a ton of data. What is happening with all this data? Who's actually analyzing it? How is it stored and what's that flow through from getting from the patient's body to the room where their physician is looking at it?   Andy Hughes:             And that is certainly a challenge right now that is limiting the widespread adoption of these devices into routine clinical care is, as Jessilyn mentioned. The wearables generate a vast amount of data, and right now, we need to identify and develop a way as clinicians to sort through all of the noise in order to be able to identify the information that is clinically meaningful and worthy of action without significantly increasing the workload.   And a few of the barriers that will be necessary in order to reach that point is, one, finding ways to integrate the wearables' data into the electronic health record and also developing some machine learning algorithms or ways with which we can use the computational power of those technologies to be able to identify when there is meaningful data within all of the vast data that comes from wearables. So it's somewhere that certainly we need to get to for these devices to reach their full clinical potential, but we are limited right now by a few of those challenges.   Jessilyn Dunn:             I was just going to say, I will add on to what Andy was saying about this idea behind digital biomarkers because this fits really nicely with this idea that giving people this huge data deluge is not helpful, but if we had a single metric where we can say, "Here's the digital biomarker of step count, and if you're above some threshold, you're good to go. And if you're below some threshold, some intervention is needed." That's a lot of the work that we've been doing, is trying to develop what are these digital biomarkers and how can they be ingested in a really digestible way?   Cindy St. Hilaire:        Yeah, that's great. Regarding the clinical and the research grade devices, I know a Fitbit or Apple Watch can sometimes be used for those, but I guess I'm talking also about the other kind of more clinically oriented devices, how good is compliance and how trustable is that data? Everybody's on probably their best behavior when they're in the office with the physician or if they're on the treadmill in the cardiac lab, but home is a different story. And what don't we know about compliance when people are out of the office and the reliability of that data that's generated in that space?   Andy Hughes:             I think you touched on a really important point right here, and one of the potential advantages of these wearable devices is that they provide continuous long-term monitoring over the course of weeks to months to years as opposed to those erratic measurements that we get from the traditional office visits or hospitalizations where, for example, the measurements we're taking are either in a supervised environment with a six-minute walk distance, for example, or self-reported or questionnaires.   So we build upon that information, but then additionally, we go beyond the observer effect where many individuals, the first week or two that you're wearing this new device, you may be more prone to increase your activity because you know that you're being monitored or you have this novel technology, but as you wear it for months to years, you outgrow those potential biases and you really can garner more comprehensive information.   In terms of compliance, we can speak to some of the research studies that have either really struggled with compliance and that limits the interpretability of their results and something we'll need to address in the future, but I think that's something that can be addressed with future studies keeping in mind all of the advantages that these devices offer compared to some of the traditional measures that we have used in the past.   Cindy St. Hilaire:        With all this data we're collecting, whether it be biological data or even just behavioral data, have we actually learned anything new? And I mean that in terms of All Of Us study this, I don't know, it was like 5,000 patients I think, and lo and behold, it found out that higher step count correlated with lower risk for a ton of diseases, which is not exactly groundbreaking. So are we, at this point in time, learning anything new from the use of these at-home devices, or are they really just able to help us enforce what we thought we knew regarding behavior?   Andy Hughes:             I think these devices have certainly provided some novel insights that build upon our understanding of physical activity. Many of us can hypothesize that decreased activity would have poor outcomes on health, which the studies have demonstrated in many facets. But in reference to All Of Us study that you mentioned, I think it's interesting to look as well at some of the diagnoses or conditions that were associated with decreased activity.   For example, reflux disease was also highlighted in that study, which may not have been identified if we didn't have the vast data and ability to really look for associations with diseases that have not been previously studied or thought to be related to physical activity. So I think that's one of the strong features of that database, is the wealth of knowledge that really will be hypothesis generating and help to inform future studies as we look even beyond cardiovascular conditions.   Cindy St. Hilaire:        One question, and you did bring it up in a bit of the discussion in your piece, is the bias that is in these devices. We know from COVID at-home pulse oximeters do not work as efficiently on darker skin. We actually know that going into bathrooms with the hand sensors that spit out the paper towels. So what kind of disparities or biases do these devices create or reinforce in the population?   Jessilyn Dunn:             This is such a critical topic because a lot of these issues had been discovered retrospectively because the people who were developing the technologies were not the representative of the people who were using the technologies. I think that's something that across the board we've been looking at from device development to AI implementation, which is having people who are going to be using the devices in the process of developing the technology and having voices heard from across the board.   We did a detailed look when we were evaluating devices for their accuracy at this exact question of where the heart rate sensors in smartwatches use optical based technology. And there was some evidence that was also an issue for people with varying skin tones, for people with wrist tattoos or more hair or freckles. And so, we did a deep dive and the generation of devices that we looked at which would meet this study was probably about three years ago.   We didn't see any discrepancies. And so, that's just one study and there are many more to be done, but I think prior to the technology development as well as once the technology comes out, keeping an eye on how that technology is doing, whether there are continued reports of failure of the technologies is really important. And there are a lot of ways that we can be vigilant about that.   Cindy St. Hilaire:        Yeah, that's great. And so, Andy, regarding patient populations, I can also see perhaps socioeconomic implications of this because smartwatches are not cheap. So how do we see that in terms of helping our patients? Are we going to be able to get a smartwatch through our insurance company?   Andy Hughes:             I think that's one of the really important next steps, is finding ways to make sure that as we advance the field of wearable devices in clinical care, that we recognize some of the existing inequities in terms of access to care, access to digital technologies that currently exist, and find ways by partnering with health insurance companies and the industry and providers and members of that community, finding ways to not only advance wearables, but use it in a way that we can decrease health disparities by really helping to increase access for these digital technologies to the underserved communities.   Jessilyn Dunn:             Yeah, the beauty of these technologies is that truthfully, at their core, they're very cheap. They're not difficult to develop, they're not difficult to build and disseminate. So a lot of what we think about is the infrastructure that goes around these devices. Does it require a smartphone to transfer data? Does it require internet access? What are the other pieces that need to be in place for these devices to work within an ecosystem? So this starts to get to questions beyond the devices themselves, but there's certainly a lot to think about and be done in the area of equity and ensuring that these devices can help everyone.   Cindy St. Hilaire:        And there's also the, I guess, ethical considerations of who owns this data. Obviously, if it's a consumable that you went and bought at Target, that's probably different than the one you're getting from your cardiologist. But who owns the data? Who has access to it? And are there any cases in the literature where an individual who's had certain measurements taken, have those measurements come back to bite them?   And I guess I'm thinking of something like cardiac rehab. If a patient doesn't get up and move enough or doesn't follow their physical therapy enough or lose weight quick enough, could their insurance coverage get cut? Could their premiums go up? What safeguards are in place for these very tricky situations? Are there safeguards in place?   Andy Hughes:             And on the clinical side, I think it will be important to treat this information just like any other protected health information that we have as part of the electronic health record. And so, there will be inherently safeguards around that in a similar manner for how we treat other protected health information.   But I think another important component of that will be a very clear consent policy when we reach the point that patients are consenting to include this information and their electronic health record, in terms of what the proposed benefits are and the potential risks associated with it, because it really is a vast amount of unique data that needs to be protected and safeguarded. And part of that comes by treating it as protected health information, but we will also need to make sure that there's a very clear consent policy that goes with it.   Cindy St. Hilaire:        Yeah. What do we see as the next steps in wearable devices? What do you guys see as the next big thing? I know one's coming from the actual AI and device side of things, and the other one is coming from the clinical side of things. What do each of you see as the next thing in this field?   Jessilyn Dunn:             I think on the device and AI side of things, I think we're thinking toward improving battery life, increasing the suite of sensors that are being added to these devices so we have a wider variety of measurements that are more representative of physiology, and then better algorithms to have better detection of sleep or activity or certain types of activity or certain types of arrhythmias. This combination of hardware and software and algorithms, I think coming together as all of these different pieces evolve will show us some really cool technology in the years to come.   Andy Hughes:             And I think from a clinical side, it's really twofold moving forward. I think as Jessilyn mentioned, there's a lot of novel sensor technologies that have a lot of exciting and evolving potential that we can hopefully integrate into the clinical space, but on the other hand, it's how can we use these wearable devices to enhance traditional therapies that we're already using?   For example, if we take the heart failure population, is there a way that we can use the wearable devices and the existing measurements with heart rate and physical activity and blood pressure to find a way to improve remote management and safely up-titrate guideline directed medical therapy, which are medications that we know have clinical benefit. But can we augment their clinical benefit and their utility by using some of the existing technologies that we already have?   And then lastly, building upon the initial studies with larger trials in more diverse generalizable populations to really enhance our understanding of the benefits that these devices may have for different cardiovascular conditions.   Cindy St. Hilaire:        Well, this was wonderful. Dr Andrew Hughes and Dr Jessilyn Dunn, thank you so much for joining me. The review, Wearable Devices in Cardiovascular Medicine, will be out in our March 3rd issue of Circulation Research. I forget which one, so I'll have to edit that out. Thank you so much for joining us, and I learned a ton. This was great.   Jessilyn Dunn:             Thank you.   Andy Hughes:             Thank you.   Cindy St. Hilaire:        That's it for our highlights from the March 3rd and March 17th issues of Circulation Research. Thank you for listening. Please check out the Circulation Research Facebook page and follow us on Twitter and Instagram with the handle @CircRes and #DiscoverCircRes. Thank you to our guests, Dr Andrew Hughes and Dr Jessilyn Dunn.   This podcast is produced by Ishara Ratnayaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy texts for the highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, you're on-the-go Source for the most exciting discoveries in basic cardiovascular research.   This program is copyright of the American Heart Association, 2023. The opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more information, visit ahajournals.org.  

The SSI Orbit Podcast – Self-Sovereign Identity, Decentralization and Web3
#47 - Mobile Driving Licence (mDL): Exploring ISO 18013-5&7 (with Andrew Hughes)

The SSI Orbit Podcast – Self-Sovereign Identity, Decentralization and Web3

Play Episode Listen Later Jan 27, 2023 56:28


Andrew Hughes CISM CISSP is Director of Identity Standards at Ping Identity. He is a digital identity strategist contributing to international standards development. He works with international associations and standards bodies as a domain expert, developing standards and related conformity assessment materials. Andrew serves on the Board of Directors of Kantara Initiative, and as the Chair of the Kantara Leadership Council. As a national expert delegate for Standards Canada on digital identity, he contributes to development of international standards at ISO SC 27 for identity management and ISO SC 17 for mobile driving licenses and mobile eID. Andrew is currently investigating how the worlds of Government Issued Photo ID can co-exist with the emerging Verifiable Credentials models, in a mobile-first manner. About Podcast Episode Read more about the episode by heading to https://northernblock.io/mobile-driving-licence-mdl-exploring-iso-18013-5-7. Some of the key topics covered during this episode with Andrew are: Distinguishing the mobile driving licence (mDL) credential type from a verifiable credential (VC). How the mDL standard is working towards being consumed by other credential transport protocols (e.g., DIDComm, OIDC4VC) Can the same ISO standard for mDL be used to issue non-driving licence credentials? And should it? Do issuers of driving licences consider mDL it as a driving licence credential, or an identity credential? What does the ecosystem look like for mDL vs the one for physical driving licences? Who are some new participants that aren't involved in physical DL production and governance? Why implementation supersedes the standard work. What are some interesting use cases around mDL that are gaining traction? How ISO works and how the relevant mDL sub-committees are evolving the standard. Are there concerns with the mobile hardware and OS providers gaining too much control over the mDL credentials? Where to find Andrew? LinkedIn: https://www.linkedin.com/in/andrew-hughes-682058a/ Twitter: https://twitter.com/IDIMAndrew Follow Mathieu Glaude Twitter: https://twitter.com/mathieu_glaude LinkedIn: https://www.linkedin.com/in/mathieuglaude/ Website: https://northernblock.io/

CrossFit Edwardsville Community Podcast
CrossFitter Feature & Success Story- Andrew Hughes (Busy Working Dad & Husband)

CrossFit Edwardsville Community Podcast

Play Episode Listen Later Dec 29, 2022 33:47


TO LEARN MORE:       www.CrossFitEdwardsville.com       www.Facebook.com/CrossFitEdwardsville      TikTok: @crossfitedwardsville      Instagram: @crossfitedwardsville        Twitter: @cfedwardsville        YouTube: CrossFit Edwardsville TO GET STARTED AT CFE:     Book a No-Sweat Conversation with a coach, using this scheduler:        https://go.oncehub.com/conversationwithcoach       You can also find the link to schedule on our website. While this show is educational & entertaining in nature, it does not replace or supplant professional medical guidance from your own physician. Before beginning any exercise or nutrition program, please first consult with your doctor. 

The Hunting 101 Podcast
Ep.126: Setups, Plans, and Expectations

The Hunting 101 Podcast

Play Episode Listen Later Dec 14, 2022 68:29


Dylan is joined by National Champion Strongman, Joey Szatmary, Trophy Ridge's Andrew Hughes, and outfitter, Gabe Ledbetter to talk about their new 2023 setups and their initial thoughts on the new bows, as well as their game plan and expectations for their week in camp at Hill Creek Outfitters.

Kerith West Wight Podcast
Ten Talk Sunday - Nick Rudd & Andrew Hughes - 24.7.22

Kerith West Wight Podcast

Play Episode Listen Later Jul 24, 2022 24:07


Australia Today with Steve Price
Why political advertising doesn't need to be truthful

Australia Today with Steve Price

Play Episode Listen Later Apr 21, 2022 8:26


Steve Price speaks to ANU political advertising expert Andrew Hughes. See omnystudio.com/listener for privacy information.

Achievements & Strategies w/Brian Franklin
EP 17: Andrew Hughes - Explorer who summited Mount Everest, Seven Summits, South Pole and more

Achievements & Strategies w/Brian Franklin

Play Episode Listen Later Apr 1, 2022 67:01


In the wake of a failed congressional race and divorce, Andrew began climbing mountains, and started a journey that would literally take him to the top of the world, Mount Everest. Andrew has completed the seven summits, six of the seven volcanic summits, and the South Pole. He and his climbing partner look to be the 11th and 12th explorers in history to climb the seven summits, the seven volcanic summits, and be on the North and South poles (the "Explorer's Grand Slam"). In this provocative and moving interview, Andrew talks about the emotion not only of reaching these great heights, but the lessons learned from both failed attempts at summits and returning to daily life in Seattle after Everest. This is an interview you don't want to skip.

All Around Growth
Ep. 277 - Winter Preparedness (and what NOT to do!)

All Around Growth

Play Episode Listen Later Feb 3, 2022 25:46


Do you own a generator?  Tell us what kind of generator you own in the group chat on Telegram at https://t.me/allaroundgrowth - which is part of what we're talking about today!   Winter preparations on the the homestead here in NE Ohio - that's the topic of today's show.  This show was inspired by my actions last night...which were inspired by YOU - the audience!  Shout out to Andrew Hughes for getting the conversation going on preps and getting his own generator going recently and inspiring the conversation today about winter preparedness.  Rob also talks about returning to more homestead oriented topics on the show and feels like a real man as he throws the truck in four wheel drive during this mornings squirrely commute.  Also...why is preparedness so divisive?  Rob talks about the culture of blame and how he got introduced to the idea of preparedness in the first place and why he finds it appealing.   ~ Connect on social media!  Twitter - https://twitter.com/allaroundgrowth Telegram Group Chat - https://t.me/allaroundgrowth Flote - https://flote.app/allaroundgrowth Facebook Page - https://www.facebook.com/allaroundgrowth Facebook Group - https://www.facebook.com/groups/allaroundgrowth ~  Subscribe to the All Around Growth Podcast Telegram Channel for show updates ONLY:    https://t.me/allaroundgrowthpodcast  ~Follow this link to ALL EPISODES   ~ How To Leave a Rating & Review in Apple Podcast AppThis really *does* affect the algorithm......as of recording in January 2022 - I would invite you to do this!The podcast game is changing - help us with a rating and review!~Have a Question or any feedback for Rob?Send me an email at allaroundgrowth@gmail.com~Discussion Links:Ep. 269 - Keeping Spare Fuel on The HomesteadRIDGID 100 ft. 12/3 Outdoor Extension CordRIDGID 5-Outlet Extension Cord Hub 36009 - The Home Depot8750 Watt Gas Powered Portable Generator, EPA - Harbor ...Wavian Fuel Can — original NATO Jerry Can | RedScepter 5 Gal. Smart Control Gas Can FR1G501 - The ...Survival PodcastLive Free Academy – Support You Need to Live Free NowSupport the show (https://www.patreon.com/allaroundgrowth)

Singletrack with Mathias Eichler and Douglas Scott
219: 'No Shortcuts Through Khumbu', with Andrew Hughes

Singletrack with Mathias Eichler and Douglas Scott

Play Episode Listen Later Jan 31, 2022 53:00


High altitude mountaineer and explorer Andrew Hughes joins us for a very special episode of Singletrack to share his story and journey from growing up in the shadow of Mount Rainier to climbing the Seven Summits. LINKS Andrew Hughes Andrew Hughes on Instagram First Ten to the Top – Brand new Singletrack Shirt now available.

Exploring Washington State
Andrew Hughes: Keeping One Foot On The Mountain and One Foot In Advocacy. A Climbers Story

Exploring Washington State

Play Episode Listen Later Jan 12, 2022 75:48


Andrew Hughes Seattle area high altitude athlete is our guest for this episode.Growing up in Poulsbo Andrew grew up playing outside and enjoying nature. He also grew up with Mount Rainier visible to him on a regular (remember we have clouds here) basis.  Life has a way of happening and it was not until Andrew was in his 30's that Mount Rainier would be a major player in Andrews life.Climbing Mount Rainier helped open Andrew to a world of challenges and opportunities.  He has now climbed the highest peaks on every single continent!  In 2022 he will be going to the north pole on an expedition.  Climbing, hiking, and high altitude athletic activities are now an iintegral part of Andrew's lifeDuring our conversation Andrew shares stories about some of his climbs. How he purposed to his finance from the summit of Mount Everest!  How climbing, and exploring can help raise awareness of Human Rights, Conservation, and Environmental issue.  We also find out how coffee can be considered self care when climbing mountains!If you are an outdoor enthusiast you will find Andrew to be inspirational.  If you have a desire to climb mountains Andrew's journeys can help motivate, educate and inspire.   Grab a cup of coffee and listen in to Andrew Hughes as he tells us how he Keeps One Foot On The Mountain and One Foot in Advocacy.Thanks for tuning into this episode of the Exploring Washington State Podcast! If the information in our conversations and interviews are enjoyable and valuable to you, please head over to iTunes, subscribe to the show, and leave us an honest review. Your reviews and feedback will not only help us continue to deliver great, helpful content, but it will also help us reach even more amazing listeners just like you! If you want to read about some of the many amazing places to explore in Washington State, you should just pack your bags and go! Explore Washington State is the perfect place for inspiration.    Check it out today.  Support the show (https://www.buymeacoffee.com/ExploringWash)

Identity, Unlocked.
The Mobile Driving License Spec with Andrew Hughes

Identity, Unlocked.

Play Episode Listen Later Jan 10, 2022 34:15


Tax Notes Talk
200 Episodes: Tax Notes Talk's Defining Interviews

Tax Notes Talk

Play Episode Listen Later Jan 7, 2022 35:27 Transcription Available


In honor of Tax Notes Talk's 200th episode, we review some of our favorite interviews and discussions from the last 100 episodes.In our “In the Pages” segment, Andrew Hughes, a Brussels-based economist who specializes in transfer pricing, valuation, and risk management, chats about his Tax Notes series on transfer pricing. Listen to our 100th episode: Tax Notes Goes To Court (Again) Find out the answer to the tax trivia question by listening to The Category Is Tax Trivia.Listen to the episodes mentioned:Wealth, Inequality, and Taxes in the U.S.Talking With the National Taxpayer Advocate: A Look AheadThe End Is Nigh: An Update on the OECD Tax Reform PlanTalking With Paul Tang: Tax Fairness in the EUHow Tax Policy Can Help Low-Income Americans' Pandemic PlightTalking With the Tax Court Chief Judge: A Year of Change50 Years Later: The Fight for Tax TransparencyThe BEPS Project: 5 Years LaterA Very Special EpisodeFrom Henry VIII to James Bond: Weird Tax Facts Throughout HistoryThe CARES Act: What's New and What's Next Follow us on Twitter:David Stewart: @TaxStewTax Notes: @TaxNotes**This episode is sponsored by the the American Bar Association Tax Section. For more information, visit ambar.org/taxnotes.This episode is sponsored by the UC Irvine School of Law's Graduate Tax Program. For more information, visit https://ce.uci.edu/?utm_source=TNM&utm_medium=podcast&utm_campaign=2022taxnote.This episode is sponsored by the UC Irvine School of Law's Graduate Tax Program. For more information, visit the-tare.com.***CreditsHost: David D. StewartExecutive Producers: Jasper B. Smith, Paige JonesShowrunner and Audio Engineer: Jordan ParrishGuest Relations: Christa Goad

All Around Growth
Ep. 251 - Free Talk after the Big City

All Around Growth

Play Episode Listen Later Dec 23, 2021 40:10


In today's episode, Rob shares his thoughts on an extended fast leading into the winter solstice, and his follow up in the journey of Functional Medicine up in the big city!  ~  Links:    The Side Hustle Snowball: How to “Erase” Your Expenses with Extra Income StreamsHat tip to Andrew Hughes for the suggestion!FREE DOWNLOAD - 2022 Goal Setting Workbook   48 Days Eagles Community  Living the life of your dreams starts with a solid financial plan. Join my virtual Financial Peace University class and learn to dump debt and build wealth. You won't even have to leave home. Visit fpu.com/1141840 to sign up for my class and start your 14-day free trial of Financial Peace. Class starts Thursday, January 20, 2022.~ If you want to participate in a group chat with fellow audience members on a similar path, you can join the community on our Telegram chat group:  t.me/allaroundgrowth    Subscribe to the All Around Growth Podcast channel for show updates ONLY:  https://t.me/allaroundgrowthpodcast  ~ Please spread the word and share on social media as well! Follow this link to ALL EPISODES   ~ How To Leave a Rating & Review in Apple Podcast AppThis really *does* affect the algorithm......as of recording in November 2021 - I would invite you to do this!The podcast game is changing - help us with a rating and review!~Have a Question or any feedback for Rob?Send me an email at allaroundgrowth@gmail.com~Notes:Solstice talkExtended fast72 hour fastWinter Solstice - fast, read, write, reflect, rest, clean, feast, fire, yule logall in silence, no devices, commToday easy morning follow up appointment with Michael Siciliano / Functional MedicineElimination Diet +2 monthsLab & Testing ReviewClarity of thought with dietOut of balance, will continue with dietMold and a parasiteLink between gut and brainTaking podcast in a new directionReality of not sharing the podcast has been a lack of pride in my work Montetizing your hobbies - nick loper link?Future promotion of the showRotating Days of ContentFinancialPhysicalPersonal DevelopmentFamilySpiritualSocialCareer2022 Goal Setting WorkbookFocus on the show for next year, focus on "business aspect" of the podcast over the next two months, try to get the show "self supporting" and "sustainable"2022 = Year of FamilyQ1 = Personal Development / Finalize Plans for YearQ2 = Family (Spring Market season - the ramp up of the season)Q3 = Spiritual (Take a spiritual retreat)Q4 = Social2023 = CareerWhy is my dog named Toby?Support the show (https://www.patreon.com/allaroundgrowth)

Soma Downtown Podcast
Ruth: Waiting Under the Wings of God | Ruth 1, 4:13-21 | Advent: The Family God Creates

Soma Downtown Podcast

Play Episode Listen Later Dec 15, 2021 27:41


Andrew Hughes from Soma Northwest continues our advent series through the story of Ruth and encourages the church through Ruth's faithfulness to trust God as she awaited salvation and redemption from being cast aside as a destitute widow, and God's faithfulness to Ruth in her waiting.

Hack
Can TikTok memes influence an election?

Hack

Play Episode Listen Later Dec 8, 2021 30:00


As the federal election looms next year, a new cohort of politically-engaged young people are turning Tiktok's signature trends into some serious (and not so serious) Auspol content. But what if the posts you've been seeing were paid for by the political parties themselves? Australia has joined the US in staging a diplomatic boycott of the Winter Olympics in Beijing next year because of human rights abuses in China. Plus, would you move to the bush to work, if it meant all of your uni debt was wiped? Live guests: Andrew Hughes, political advertising researcher at Australian National University Zali Steggall, Independent Federal MP, and former Olympian Kate, junior doctor from Albury Dr Dan Wilson, Rural Doctors Association

Backpacker Radio
#126 | Andrew Hughes

Backpacker Radio

Play Episode Listen Later Nov 15, 2021 98:29


In today's episode of Backpacker Radio, presented by The Trek, we are joined by Andrew Hughes.  Andrew is quite possibly the most accomplished mountaineer that you have never heard of.  Some of his feats include climbing the highest summit in all seven continents and six of the seven highest volcanic summits, he's the third person ever to complete the Antarctica Trifecta, and he's very close to completing the Explorers' Grand Slam.  If you're not familiar with what these last two feats are, you're certainly not alone, we do a deep dive on all this and much more. We learn about a missing hiker who ignored rescuers' calls for a hilarious reason, a very last minute, seasonal triple crown, and we hear from Chaunce's #1 fan.  

Off the Mark
Off the Mark Special #046 “NXT Eulogy”

Off the Mark

Play Episode Listen Later Aug 20, 2021 46:17


Andrew, Aaron, Roger, and Doug talk about the sad passing of NXT. We go over some of the key releases and what the future may hold with NXT 2.0. As always be sure to follow the show @OfftheMark86, Andrew Hughes @ahughes86, and Aaron Hughes @aphughes. If there are any topics you guys would like us […]

Section_86
Off the Mark Special #046 “NXT Eulogy”

Section_86

Play Episode Listen Later Aug 20, 2021 46:17


Andrew, Aaron, Roger, and Doug talk about the sad passing of NXT. We go over some of the key releases and what the future may hold with NXT 2.0. As always be sure to follow the show @OfftheMark86, Andrew Hughes @ahughes86, and Aaron Hughes @aphughes. If there are any topics you guys would like us […]

The TKE Nation Podcast
S2: E25 | Ft. Andrew Hughes

The TKE Nation Podcast

Play Episode Listen Later Jul 7, 2021 35:10


Fresh off the peak of Mount Everest, Frater Andrew Hughes is back! Frater Hughes (Chi, Washington) recently summited Mount Everest, achieving a goal many years in the making. We talk with him about the toll an endeavor like this can take on you and the highs and lows of pushing yourself to reach new heights. If you need a dose of inspiration to motivate you to reach your goals, this is the episode for you!

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Off the Mark S12E05 May 2021

Section_86

Play Episode Listen Later Jun 4, 2021 79:53


Andrew, Aaron, Roger, and Doug discuss EVERYTHING AEW the latest AEW news. We  go over the recent AEW PPV “Double or Nothing” including our favorite matches. For our monthly topic, we over our ideas for Kenny Omega’s belt collector gimmick. As always be sure to follow the show @OfftheMark86, Andrew Hughes @ahughes86, and Aaron Hughes […]

Off the Mark
Off the Mark S12E05 May 2021

Off the Mark

Play Episode Listen Later Jun 4, 2021 79:53


Andrew, Aaron, Roger, and Doug discuss EVERYTHING AEW the latest AEW news. We  go over the recent AEW PPV “Double or Nothing” including our favorite matches. For our monthly topic, we over our ideas for Kenny Omega’s belt collector gimmick. As always be sure to follow the show @OfftheMark86, Andrew Hughes @ahughes86, and Aaron Hughes […]

The TKE Nation Podcast
S2: E16 | Ft. Andrew Hughes

The TKE Nation Podcast

Play Episode Listen Later May 5, 2021 28:44


Join us for a very special episode interviewing Frater Andrew Hughes from Mount Everest Base Camp! Frater Hughes (Chi, Washington) is currently making his second attempt to summit Mount Everest. This attempt is nearly two years from the 2019 season when he fell just short of the summit after coming down with pneumonia during his summit rotation. At that time, he was evacuated by helicopter from 21,500 feet to a Kathmandu Hospital for recovery. This year he will be attempting the seldom accomplished 8000M+ double. First, climbing Everest and completing the Seven Summits, a feat roughly around only 400 people have ever accomplished, and then reaching the summit of Lhotse within 24 hours, which is the 4th highest mountain in the world—this has been achieved by only around 40 people. Additionally, he will be attempting two altitude-related Guinness World Records. To wish him well or follow along on Frater Hughes' Everest / Lhotse Expedition, follow him on Instagram (@andrew_i_hughes). Visit TKE.org/Everest for links and to follow along on his climb. :55 Andrew Hughes Recorded Live At Mount Everest Base Camp 1:50 Insanely Impressive Accomplishments 2:45 What Is The Explorer's Grand Slam? (Hint: It's very exclusive.) 3:42 How Do You Prepare For These Feats? 5:20 The TKE Connection 7:30 Pursue Your Passion; Opportunities Present Themselves 9:00 Everest Expedition Logistics (Two months of pushing human limits.) 11:00 In The Death Zone For Four Days 14:30 Tackling Everest For The Second Time 16:14 Back To Back On The Worlds Largest Peaks 17:35 Trench Foot, Frost Bite, Hypothermia (Antarctica is relentless.) 18:00 Altitude Is The Great Equalizer 18:21 The Impact Of COVID-19 20:00 Rapid Fire Questions 20:37 Favorite Place in All The World? 21:00 Humbled in Antarctica, Among Other Places 22:00 Spiritual Experience 24:00 Why Pro Athletes Cry 25:00 Finding Communities 26:15 New World Records On The Horizon

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Off the Mark Special #044 “Wrestlemania 37 2021 Preview”

Section_86

Play Episode Listen Later Apr 5, 2021 65:36


Andrew, Aaron, Roger, and Doug talk about the full two day Wrestlemania 37 card. This is our 12th annual WrestleMania special! We discuss our predictions on each of the match outcomes. We also discuss the Two Night Event for NXT TakeOver: Stand and Deliver. As always be sure to follow the show @OfftheMark86, Andrew Hughes […]

Off the Mark
Off the Mark Special #044 “Wrestlemania 37 2021 Preview”

Off the Mark

Play Episode Listen Later Apr 5, 2021 65:36


Andrew, Aaron, Roger, and Doug talk about the full two day Wrestlemania 37 card. This is our 12th annual WrestleMania special! We discuss our predictions on each of the match outcomes. We also discuss the Two Night Event for NXT TakeOver: Stand and Deliver. As always be sure to follow the show @OfftheMark86, Andrew Hughes […]

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Off the Mark Special #043 “Royal Rumble 2021 Preview”

Section_86

Play Episode Listen Later Jan 28, 2021 25:09


Andrew, Aaron, Roger, and Doug preview Royal Rumble 2021.  We give our analysis on each of the matches. We then give our expectations of the Men’s and Women’s Royal Rumble matches! As always be sure to follow the show @OfftheMark86, Andrew Hughes @ahughes86, and Aaron Hughes @aphughes. If there are any topics you guys would […]

Off the Mark
Off the Mark Special #043 “Royal Rumble 2021 Preview”

Off the Mark

Play Episode Listen Later Jan 28, 2021 25:09


Andrew, Aaron, Roger, and Doug preview Royal Rumble 2021.  We give our analysis on each of the matches. We then give our expectations of the Men’s and Women’s Royal Rumble matches! As always be sure to follow the show @OfftheMark86, Andrew Hughes @ahughes86, and Aaron Hughes @aphughes. If there are any topics you guys would […]

Big Talk For Breeders
12: Big Talk For Breeders with Andrew Hughes

Big Talk For Breeders

Play Episode Listen Later Dec 24, 2020 57:03


Episode 12 of Big Talk For Breeders. Andrew Hughes, Ennisnag Stud Ireland, interviewed by Michael Doherty. Website: esisporthorses.com/ (https://gate.sc/?url=https%3A%2F%2Fesisporthorses.com%2F&token=41ed15-1-1608840895442) Facebook: www.facebook.com/Ennisnag-Stud-Ir…-227836693910825 (https://gate.sc/?url=https%3A%2F%2Fwww.facebook.com%2FEnnisnag-Stud-Ireland-227836693910825&token=7997ab-1-1608840895442) Show Notes: Arabella - bit.ly/37Ob2lW (https://gate.sc/?url=https%3A%2F%2Fbit.ly%2F37Ob2lW&token=f39c47-1-1608840895442) Cavalier Royale - bit.ly/37J4BAO (https://gate.sc/?url=https%3A%2F%2Fbit.ly%2F37J4BAO&token=769c35-1-1608840895442) Bravour VDL - bit.ly/3rqTILQ (https://gate.sc/?url=https%3A%2F%2Fbit.ly%2F3rqTILQ&token=5c5c3b-1-1608840895442) Cornet Obolensky - bit.ly/38wCDaA (https://gate.sc/?url=https%3A%2F%2Fbit.ly%2F38wCDaA&token=ffdc2f-1-1608840895442) Emerald - bit.ly/37Rovd7 (https://gate.sc/?url=https%3A%2F%2Fbit.ly%2F37Rovd7&token=6a9c2a-1-1608840895442) ESI Toulouse - bit.ly/34D4q8f (https://gate.sc/?url=https%3A%2F%2Fbit.ly%2F34D4q8f&token=1fdc4d-1-1608840895442) ESI Rocky - bit.ly/34HsLJQ (https://gate.sc/?url=https%3A%2F%2Fbit.ly%2F34HsLJQ&token=4fdc3b-1-1608840895442) ESI Star Struck - bit.ly/3mNSG9h (https://gate.sc/?url=https%3A%2F%2Fbit.ly%2F3mNSG9h&token=541c4d-1-1608840895442) Hos D’O - bit.ly/2WLnL2x (https://gate.sc/?url=https%3A%2F%2Fbit.ly%2F2WLnL2x&token=488c5c-1-1608840895442) Kilkenny Lady - bit.ly/37KCTn5 (https://gate.sc/?url=https%3A%2F%2Fbit.ly%2F37KCTn5&token=139c28-1-1608840895442) Mendoza VDL - bit.ly/3pn1DYJ (https://gate.sc/?url=https%3A%2F%2Fbit.ly%2F3pn1DYJ&token=bcec36-1-1608840895443)

All Around Growth
Ep. 69 - Exploring Creativity

All Around Growth

Play Episode Listen Later Dec 22, 2020 19:16


Today, Rob's getting a late start with the podcast on his first day of winter break! Join him as he discusses how he's going to dive into cultivating creativity on his way into town!Many thanks to Andrew Hughes for the topic suggestion!Have a Question for Rob?Send your questions to allaroundgrowth@gmail.comJoin the community:t.me/allaroundgrowth CLICK HERE TO RATE AND REVIEW THE PODCASTSupport the show (https://www.patreon.com/allaroundgrowth)

All Around Growth
Ep. 53 - Fists of Anger (AND...?)

All Around Growth

Play Episode Listen Later Dec 1, 2020 29:59


Today, we're going to talk about anger. Yep...*that* kind of anger. Fists of Anger. During the morning commute - I will share some experiences and stories about stress and anger... ...and I will also share an awesome experience that is a direct result of *this* community.All Around Growth is having a positive and beneficial impact on my life... ...and today, you will learn how it can have the same impact on your life.Shout out to Steph McCoy and Andrew Hughes - they are VIP / #1 fans!Check out the All Around Growth community chat on Telegram:https://t.me/allaroundgrowth It was there that Steph shared a simple, but profound message:It's a hard time of year. Thank him for taking care of himself and move on. This comment was followed by: Oh and do the fists of anger.Fists of Anger - https://youtu.be/nXcdctEHdRA Rob shares emotional experience of:Fists of Anger ExerciseQigong for Stress ReliefEpisode 13 - On Physical WellnessMyofascial Release (John Barnes School) Myofascial release is an alternative medicine therapy claimed to be useful for treating skeletal muscle immobility and pain by relaxing contracted muscles, improving blood, oxygen, and lymphatic circulation, and stimulating the stretch reflex in muscles. - WikipediaWe don't process anger well in today's world.We are all subject to societal programming.We can overcome it.These exercises, Fists of Anger, Qigong for Stress Relief, and Myofascial Release bodywork allow us to effectively create an environment conducive to healthy, positive, beneficial change CLICK HERE TO RATE AND REVIEW THE PODCAST Have a Question for Rob? Send your questions to allaroundgrowth@gmail.com Join the community:t.me/allaroundgrowth Support the show (https://www.patreon.com/allaroundgrowth)