Podcasts about research roundup

The Research Round-Up returns! Hosts Silvia Radenkovic and Rodrigo Starosta are joined by Dr Hilary Vernon and Dr Austin Larson for a deep dive into the latest discoveries in mitochondrial disease. Together they explore how new biomarkers like FGF21 and GDF15 are reshaping diagnosis, how multi-omics approaches are accelerating precision care, and what large-scale data from gnomAD to stem-cell models is revealing about disease mechanisms and therapeutic opportunities. A lively, expert-led discussion connecting science, diagnostics, and patient impact across the mitochondrial field. Laricchia KM, et al Mitochondrial DNA variation across 56,434 individuals in gnomAD. Genome Res. 2022 Mar;32(3):569-582. doi: 10.1101/gr.276013.121. Epub 2022 Jan 24. PMID: 35074858; PMCID: PMC8896463. Liu O, et al FGF21 and GDF15 are elevated in Barth Syndrome and are correlated to important clinical measures. Mol Genet Metab. 2023 Nov;140(3):107676. doi: 10.1016/j.ymgme.2023.107676. Epub 2023 Aug 2. PMID: 37549445. Van Hove JLK, et al Protein biomarkers GDF15 and FGF21 to differentiate mitochondrial hepatopathies from other pediatric liver diseases. Hepatol Commun. 2024 Jan 5;8(1):e0361. doi: 10.1097/HC9.0000000000000361. Erratum in: Hepatol Commun. 2024 Jan 29;8(2):e0390. doi: 10.1097/HC9.0000000000000390. PMID: 38180987; PMCID: PMC10781130. Starosta RT, et al An integrated multi-omics approach allowed ultra-rapid diagnosis of a deep intronic pathogenic variant in PDHX and precision treatment in a neonate critically ill with lactic acidosis. Mitochondrion. 2024 Nov;79:101973. doi: 10.1016/j.mito.2024.101973. Epub 2024 Oct 15. PMID: 39413893; PMCID: PMC11578067. Jain IH, et al Hypoxia as a therapy for mitochondrial disease. Science. 2016 Apr 1;352(6281):54-61. doi: 10.1126/science.aad9642. Epub 2016 Feb 25. PMID: 26917594; PMCID: PMC4860742 Sandlers Y, et al Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function. PLoS One. 2016 Mar 25;11(3):e0151802. doi: 10.1371/journal.pone.0151802. PMID: 27015085; PMCID: PMC4807847. Sniezek Carney O, et al. Stem cell models of TAFAZZIN deficiency reveal novel tissue-specific pathologies in Barth syndrome. Hum Mol Genet. 2025 Jan 23;34(1):101-115. doi: 10.1093/hmg/ddae152. PMID: 39535077; PMCID: PMC11756277.

In this episode Rachel Moon, MD, FAAP, associate editor of blogs for Pediatrics, offers a rundown of the November issue. David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also speak with Andrea Hadley, MD, FAAP, about the role of medical psychiatric units in supporting pediatric mental health. For resources go to aap.org/podcast.  

Wharton's Philip Nichols explains why AI isn't useful for combatting corruption, at least not yet. This Ripple Effect episode is part of the “Research Roundup” series. Hosted on Acast. See acast.com/privacy for more information.

With Rodrigo off caring for sick children, James Nurse joins Silvia Radenkovic to speak with Dr Judith Jans and Dr Devin Oglesbee about the emerging field of untargeted metabolomics. Authors' opinions are their own and do not represent their institutions. Referenced papers include: Miller MJ, et al The emerging role of metabolomics analysis in genetic and genomic testing: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2025 Jul 17:101493. doi: 10.1016/j.gim.2025.101493. Epub ahead of print. Evans AM, et al Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC-MS based untargeted metabolomics practitioners. Metabolomics. 2020 Oct 12;16(10):113. doi: 10.1007/s11306-020-01728-5. Wurth R, et al. An evaluation of untargeted metabolomics methods to characterize inborn errors of metabolism. Mol Genet Metab. 2024 Jan;141(1):108115. doi: 10.1016/j.ymgme.2023.108115. Epub 2023 Dec 15. Haijes HA, et al. Direct Infusion Based Metabolomics Identifies Metabolic Disease in Patients' Dried Blood Spots and Plasma. Metabolites. 2019 Jan 11;9(1):12. doi: 10.3390/metabo9010012. Willems AP, et al A one-year pilot study comparing direct-infusion high resolution mass spectrometry based untargeted metabolomics to targeted diagnostic screening for inherited metabolic diseases. Front Mol Biosci. 2023 Nov 2;10:1283083. doi: 10.3389/fmolb.2023.1283083. Haijes HA, et al. Aspartylglycosamine is a biomarker for NGLY1-CDDG, a congenital disorder of deglycosylation. Mol Genet Metab. 2019 Aug;127(4):368-372. doi: 10.1016/j.ymgme.2019.07.001. Epub 2019 Jul 9. PMID: 31311714. Hoegen B, et al Application of metabolite set enrichment analysis on untargeted metabolomics data prioritises relevant pathways and detects novel biomarkers for inherited metabolic disorders. J Inherit Metab Dis. 2022 Jul;45(4):682-695. doi: 10.1002/jimd.12522. Epub 2022 May 22. PMID: 35546254; PMCID: PMC9544878. Gao Q, et al A diagnostic algorithm for inherited metabolic disorders using untargeted metabolomics. Metabolomics. 2025 Jul 27;21(4):101. doi: 10.1007/s11306-025-02302-7. PMID: 40715884; PMCID: PMC12301266. Kerkhofs MHPM, et al. Cross-Omics: Integrating Genomics with Metabolomics in Clinical Diagnostics. Metabolites. 2020 May 18;10(5):206. doi: 10.3390/metabo10050206. Ashenden AJ, et al. The Multi-Omic Approach to Newborn Screening: Opportunities and Challenges. Int J Neonatal Screen. 2024 Jun 21;10(3):42. doi: 10.3390/ijns10030042. Liu N, et al. Comparison of Untargeted Metabolomic Profiling vs Traditional Metabolic Screening to Identify Inborn Errors of Metabolism. JAMA Netw Open. 2021 Jul 1;4(7):e2114155. doi: 10.1001/jamanetworkopen.2021.14155.

Silvia and Rodrigo are joined by Dr Ray Wang, Director of the multidisciplinary Foundation of Caring Lysosomal Storage Disorder Program at the Children's Hospital of Orange County. Silvia asks Dr Wang and Rodrigo (who also happens to be a researcher in this field) about cutting-edge advances in LSD research: from base editing in Pompe disease and patient-specific in vivo gene editing, to new biomarkers and scoring systems in Gaucher disease, insights into lipid dysregulation across lysosomal storage disorders, and the first clinical trial of anakinra in Sanfilippo syndrome. Papers discussed include: Christensen CL, et al Base editing rescues acid α-glucosidase function in infantile-onset Pompe disease patient-derived cells. Mol Ther Nucleic Acids. 2024 May 21;35(2):102220. doi: 10.1016/j.omtn.2024.102220. PMID: 38948331; PMCID: PMC11214518. Starosta RT, et al Predicting liver fibrosis in Gaucher disease: Investigation of contributors and development of a clinically applicable Gaucher liver fibrosis score. Mol Genet Metab. 2025 Feb;144(2):109010. doi: 10.1016/j.ymgme.2025.109010. Epub 2025 Jan 3. PMID: 39788861. Kell P, et al Secondary accumulation of lyso-platelet activating factors in lysosomal storage diseases. Mol Genet Metab. 2025 Jun 17;145(4):109180. doi: 10.1016/j.ymgme.2025.109180. Polgreen LE, et al Anakinra in Sanfilippo syndrome: a phase 1/2 trial. Nat Med. 2024 Sep;30(9):2473-2479. doi: 10.1038/s41591-024-03079-3. Epub 2024 Jun 21. Erratum in: Nat Med. 2024 Sep;30(9):2693. doi: 10.1038/s41591-024-03207-z. Musunuru K, et al Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease. N Engl J Med. 2025 Jun 12;392(22):2235-2243. doi: 10.1056/NEJMoa2504747.

What's the latest thinking in managing patellofemoral pain? Drs Erin Macri (Erasmus MC University Medical Centre, The Netherlands) and Harvi Hart (Michigan State University) join JOSPT Insights ahead of the International Patellofemoral Research Network meeting to share the latest in patellofemoral research, and what it means for clinical practice. ------------------------------ RESOURCES JOSPT Insights Ep 229: Best practice in managing patellofemoral pain, with Dr Brad Neal: https://pod.link/1522929437/episode/ZDBkY2Q0ZDYtMzNhZS00OWVjLWJlYTQtNTYwMzBkZTVhM2Iw Patellofemoral pain CPG: https://www.jospt.org/doi/10.2519/jospt.2019.0302 Clinical priorities for psychological factors in patellofemoral pain: https://www.jospt.org/doi/10.2519/jospt.2022.10647 Prognosis for patellofemoral pain: https://www.jospt.org/doi/10.2519/jospt.2025.13491 Find out more about the International Patellofemoral Research Network's work: https://ipfrn.org/

In this episode the new deputy editor of  Pediatrics joins the team.Andrea Cruz, MD, MPH, FAAP, offers a rundown of the September issue of the journal.  David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also speak with Tim Geleske, MD, FAAP, about genetic evaluation of children with intellectual disabilities or global developmental delays. For resources go to aap.org/podcast.

Today, hosts Tiffany and Katja discuss current research on female hormones, the immune system, and exercise. Both the female hormones as well as the immune function are intricate systems – bringing them together adds even more complexity! In this episode, we try to boil down the immune system and inflammatory response and explore recent research that sheds light on the relationship between the menstrual cycle, immune responses and exercise. We also discuss the nuances of inflammatory processes, individualised responses, and potential implications for peri- and post-menopause. Listen in as we talk about the influence of female hormones on immune processes and share why inner wisdom is an important part of understanding our bodies better. — Show Notes: Disclaimer – complexity of the immune system and menstrual cycle research [1:52] Inflammation and the immune system – bird's eye view [4:18] Influence of female hormones on immune and inflammatory processes [6:47] Potential changes in the second phase of the menstrual cycle [14:16] Current meta-analysis and systematic review on female hormones and immune function/ inflammation [15:43] Relationship with exercise [22:41] Current state of menstrual cycle-based training research [29:33] — Links Mentioned: Watch this episode on YouTube Female Hormones & Immune System References Doc Female Health Yoga Teacher Training Menopause Yoga Teacher Training Connect with Katja Bartsch: Facebook | Instagram | Kalamana Yoga | Yoga Medicine® Online Guest Teacher You can learn more about this episode, and see the full show notes at YogaMedicine.com/podcast-142. And you can find out more about insider tips, online classes or information on our teacher trainings at YogaMedicine.com. To support our work, please leave us a 5 star review with your feedback on iTunes/Apple Podcasts.  

In this episode, Prof Chris Vorster (Director, Centre for Human Metabolomics, North-West University, South Africa), Sarah Viall (Assistant Professor, Molecular and Medical Genetics, Oregon Health & Science University, USA) and PD Dr. med. Ulrike Mütze (Consultant, Heidelberg University Hospital, Germany) join Silvia Radenkovic and Rodrigo Starosta to explore the evolving landscape of newborn screening. They discuss national and international variations in practice, how to maintain consistency and quality, and the future scope of testing – including opportunities to improve access in resource-limited settings. Authors' opinions are their own and do not represent their institutions. Referenced papers include: Newborn screening in South Africa: the past, present, and plans for the future. Malherbe et al (2024) Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: a worldwide collaborative project. McHugh et al (2024) Five years of newborn screening for Pompe, Mucopolysaccharidosis type I, Gaucher, and Fabry diseases in Oregon. Viall & Held (2025) Long-term outcomes of adolescents and young adults identified by metabolic newborn screening. Mütze et al (2025) Treatment Outcomes for Maple Syrup Urine Disease Detected by Newborn Screening. Mengler et al (2024) Vitamin B12 Deficiency Newborn Screening. Mütze et al (2024) The role of exome sequencing in newborn screening for inborn errors of metabolism. Adhikari et al (2020)

In this episode, Alex Kemper, MD, MPH, MS, FAAP, editor of the journal Pediatrics, offers a rundown of the August issue. David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also speak with Jesse Hackell, MD, FAAP, about medical versus non-medical immunization exemptions for child care and school attendance. For resources go to aap.org/podcast.

In this episode, Dr Joost Groen, a clinical biochemist at the University Medical Center Groningen, and Dr Matt Gentry, Professor & Chair of Biochemistry & Molecular Biology in the College of Medicine at University of Florida, join Rodrigo and Silvia to discuss new insights, AI, cancer metabolism and some of their favourite papers on Glycogen Storage Disorders. Authors opinions are their own and do not represent their institutions. GSD episode papers: Brain glycogen serves as a critical glucosamine cache required for protein glycosylation. Sun et al A machine learning model accurately identifies glycogen storage disease Ia patients based on plasma acylcarnitine profiles. Groen et al Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders. Ullman et al Repurposing SGLT2 inhibitors: Treatment of renal proximal tubulopathy in Fanconi-Bickel syndrome with empagliflozin. Overduin et al Gross-Valle The relation between dietary polysaccharide intake and urinary excretion of tetraglucoside. Gross-Valle et al Glycogen drives tumour initiation and progression in lung adenocarcinoma. Clarke HA et al Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis. Conroy et al In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues. Young et al Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis. Brewer et al Dynamics of cognitive variability with age and its genetic underpinning in NIHR BioResource Genes and Cognition cohort participants. Rahman MS et al Neurological glycogen storage diseases and emerging therapeutics Colpaert et al

There are still plenty of questions about the experience of the transitional phases of our lives. Today, hosts Tiffany and Katja discuss recent research that seeks to shed light on the menopausal transition. Experience of menopause is highly variable from person to person, so in this episode, we explore common symptom clusters identified in the research as well as the phenomenon of “not feeling like myself” in perimenopause. We also talk about how midlife can pose a challenge to one's self-image and discuss how fatigue and emotional volatility may impact a woman's day-to-day in this phase of life. — Show Notes: Background on menopause and perimenopause [2:50] Symptoms of peri- and postmenopause [14:41] Symptoms that show up in all stages of menopause [27:19] The phenomenon of “not feeling like myself” in perimenopause [29:22] Symptoms related to not feeling like yourself [38:20] The role of fatigue [45:17] New sensations of emotional volatility [46:38] — Links Mentioned: Watch this episode on YouTube Menopause References Doc Connect with Katja Bartsch: Facebook | Instagram | Kalamana Yoga | Yoga Medicine® Online Guest Teacher You can learn more about this episode, and see the full show notes at YogaMedicine.com/podcast-139. And you can find out more about insider tips, online classes or information on our teacher trainings at YogaMedicine.com. To support our work, please leave us a 5 star review with your feedback on iTunes/Apple Podcasts.

In this episode Rachel Moon, MD, FAAP, associate editor of digital media for Pediatrics, offers a rundown of the July issue. David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also speak with Dana Kaplan, MD, FAAP, about human trafficking and exploitation of children and adolescents. For resources go to aap.org/podcast.

Send us a textIn this edition of our occasional recent research review, we focus on scientific evidence for dyslexic strengths.The articles we reference are:Lukic, S., Jiang, F., Mandelli, M. L., Qi, T., Inkelis, S. M., Rosenthal, E., Miller, Z., Wellman, E., Bunge, S. A., Gorno‑Tempini, M. L., & Pereira, C. W. (2025).A semantic strength and neural correlates in developmental dyslexia. Frontiers in Psychology, 15, Article 1405425. https://doi.org/10.3389/fpsyg.2024.1405425 Maw, K. J., Beattie, G., & Burns, E. J. (2024).Cognitive strengths in neurodevelopmental disorders, conditions and differences: A critical review. Neuropsychologia, 197, Article 108850. https://doi.org/10.1016/j.neuropsychologia.2024.108850Dyslexia Journey has conversations and explorations to help you support the dyslexic child in your life. Content includes approaches, tips, and interviews with a range of guests from psychologists to educators to people with dyslexia. Increase your understanding and connection with your child as you help them embrace their uniqueness and thrive on this challenging journey!Send us your questions, comments, and guest suggestions to parentingdyslexiajourney@gmail.comAlso check out our YouTube channel! https://www.youtube.com/@ParentingDyslexiaJourney

Dr Luciana Hannibal, Research Group Leader / Head of Translational Metabolomics at the Centre for Integrative Biological Signalling Studies in Freiburg, and Dr Julien Park, a Physician-scientist at the Children's University Hospital Münster, are Rodrigo and Silvia's latest guests, providing a thorough overview of disorders of Redox Metabolism. Authors opinions are their own and do not represent their institutions. Papers discussed include: Targeted Metabolic Profiling of Methionine Cycle Metabolites and Redox Thiol Pools in Mammalian Plasma, Cells and Urine Behringer et al Treatment with 2-phospho-L-ascorbic acid mitigates biochemical phenotypes of heme oxygenase 1 deficiency Berendes et al Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo Murphy et al The motor system is exceptionally vulnerable to absence of the ubiquitously expressed superoxide dismutase-1 Park et al Clinical and molecular analysis of a novel variant in heme oxygenase-1 deficiency: Unraveling its role in inflammation, heme metabolism, and pulmonary phenotype Berendes et al Redox signaling in inherited diseases of metabolism, Current Opinion in Physiology Jacobsen and Hannbal Real-time detection of enzymatically formed hydrogen sulfide by pathogenic variants of cystathionine beta-synthase using hemoglobin I of Lucina pectinata as a biosensor. Myszkowska et al

In this episode Lewis First, MD, MS, FAAP, editor-in-chief of Pediatrics, is back for a special edition of “First Up.” He offers an overview of the June issue of the journal. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also welcome a couple of surprise guests who share their favorite Lewis memories. For resources go to aap.org/podcast.

Dr Sabine Fuchs, Professor of Metabolic diseases and innovative therapies at the UMC Utrecht, and Dr Sean Froese, a Principal Investigator in the Metabolism Division at University Children's Hospital Zürich, join Rodrigo and Silvia to discuss new insights and some of their favourite papers on Methylmalonic Aciduria. Authors opinions are their own and do not represent their institutions. Papers discussed include: Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency Forny et al Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin. Head et al Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation. Manoli et al Prime editing for functional repair in patient-derived disease models Schene et al Mutation-specific reporter for optimization and enrichment of prime editing Schene et al Biomarkers to predict disease progression and therapeutic response in isolated methylmalonic acidemia. Manoli et al Fibroblast growth factor 21 as a biomarker for long-term complications in organic acidemias. Molema et al

As both yoga teachers and practitioners, it is important to understand how to take general instruction and use it to cater to your personal needs. In this episode, hosts Tiffany and Katja talk about recent research on personalized medicine and training, discuss how wearables and data collection play into individualized training programs, and relate current research findings to personalized yoga approaches. Listen to this episode to learn about the history and trends of individualised medicine and training, how to know which data to collect, why body awareness is important in individualisation, and how to take this perspective into account in a group class. — Show Notes: What is the history of personalized medicine, training, and yoga [2:04] Factors to consider [8:31] Tracking and evaluating data [12:12] Current research and potential downsides [20:37] How to individualize a group class [35:32] Recap [37:49] — Links Mentioned: Watch this episode on YouTube Connect with Katja Bartsch: Facebook | Instagram | Kalamana Yoga | Yoga Medicine® Online Guest Teacher You can learn more about this episode and see the full show notes at YogaMedicine.com/podcast-135. And you can find out more about insider tips, online classes or information on our teacher trainings at YogaMedicine.com. To support our work, please leave us a 5 star review with your feedback on iTunes/Apple Podcasts.

In this episode Alex R. Kemper, MD, MPH, MS, FAAP, deputy editor of the journal Pediatrics, offers a rundown of the May issue. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also talk to Ellen S. Rome, MD, MPH, FAAP, about the latest updates in the ninth edition of the Yellow Book, Pediatric Nutrition. For resources go to aap.org/podcast.

Can people diagnosed with metastatic hormone receptor-positive breast cancer avoid chemotherapy and take a CDK4/6 inhibitor instead? Do people diagnosed with DCIS need to have surgery? Will there soon be another oral selective estrogen degrader available? Breastcancer.org medical advisor Dr. Kevin Fox explains the details of the studies and what they mean for you. Listen to the episode to hear Dr. Fox discuss these studies: Young-PEARL: Ibrance plus Aromasin, along with ovarian suppression, offers better progression-free survival than Xeloda for pre-menopausal women with metastatic hormone receptor-positive, HER2-negative breast cancer who had previously received tamoxifen. PATINA: Adding Ibrance to standard-of-care first treatments for metastatic hormone receptor-positive, HER2-positive breast cancer increased progression-free survival by more than a year. EMBER-3:Imlunestrant led to longer progression-free survival than standard therapy if the cancer had an ESR1 mutation among people with estrogen receptor-positive, HER2-negative advanced-stage breast cancer. Adding Verzenio to imlunestrant improved progression-free survival compared to imlunestrant alone, whether the cancer had an ESR1-mutation or not. COMET: Can people with low-risk DCIS just be monitored instead of having surgery with or without radiation? 

In this episode Rachel Moon, MD, FAAP, associate editor of digital media for the journal Pediatrics, shares a research roundup from the April issue. David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also speak with Adam Ratner, MD, MPH, FAAP, and Nitya Shah, MD, FAAP, about having difficult conversations with families about a diagnosis of congenital syphilis and other diseases.  For resources go to aap.org/podcast.

Dr Matthew Wilson, Postdoctoral Fellow at the Centre for Human Genetics, KU Leuven, joins hosts Silvia Radenkovic and Rodrigo Starosta to discuss a scintillating selection of CDG papers in our first ever research round-up. The papers discussed include: A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis. Wilson et al Clinical and biochemical footprints of congenital disorders of glycosylation: Proposed nosology. Ng et al Rft1 catalyzes lipid-linked oligosaccharide translocation across the ER membrane. Chen et al Molecular characterization of Rft1, an ER membrane protein associated with congenital disorder of glycosylation RFT1-CDG. Hirata et al Genome and RNA sequencing were essential to reveal cryptic intronic variants associated to defective ATP6AP1 mRNA processing. Morales-Romero et al N-glycoproteomic and proteomic alterations in SRD5A3-deficient fibroblasts. Garapati et al In vitro treatment with liposome-encapsulated Mannose-1-phosphate restores N-glycosylation in PMM2-CDG patient-derived fibroblasts. Shirakura et al Liposome-encapsulated mannose-1-phosphate therapy improves global N-glycosylation in different congenital disorders of glycosylation. Budhraja et al D-mannose as a new therapy for fucokinase deficiency-related congenital disorder of glycosylation (FCSK-CDG). Starosta et al Glycoproteomics in Cerebrospinal Fluid Reveals Brain-Specific Glycosylation Changes. Baerenfaenger et al Neural and metabolic dysregulation in PMM2-deficient human in vitro neural models. Radenkovic et al

Send us a textThe quest for better outcomes in pediatric IBD has taken significant strides forward, and Dr. Jeremy Adler returns to Bowel Moments to guide us through the most promising research developments of the past year. Dr. Adler is a clinical Professor in the Division of Pediatric Gastroenterology at the University of Michigan and serves as the Interim Director of the Susan B. Meister Child Health Evaluation and Research (CHEAR) Center. We discuss how medication dosing strategies have evolved dramatically, with compelling evidence showing that body surface area measurements work better than traditional weight-based dosing for younger children. This seemingly simple adjustment yields dramatically better results, particularly as children grow and develop through puberty. Regular therapeutic drug monitoring—checking medication levels every 6-12 months or more frequently during growth spurts—has also proven critical for maintaining disease control in the pediatric population.Prevention emerges as the cornerstone of Dr. Adler's research and clinical philosophy. The fascinating GEM study has identified changes in gut permeability that occur before IBD diagnosis, potentially opening doors to early intervention before symptoms appear. Meanwhile, Dr. Adler's own groundbreaking research demonstrates that early, aggressive treatment with anti-TNF medications can prevent serious complications like perianal fistulas, fistulas, and abscesses—complications that significantly impact quality of life and body image.We navigate the complex terrain of treatment barriers, from insurance denials to psychological resistance to "stronger" medications. Dr. Adler challenges common misconceptions, noting that injectable or infusion medications often have better safety profiles than some oral options that patients perceive as "less intense." The conversation turns to normalizing surgical options like ostomies when needed, with Dr. Adler advocating for early introduction to surgical teams—not because surgery is imminent, but because establishing relationships reduces trauma if intervention becomes necessary.With new medication mechanisms emerging and genetic markers helping to personalize treatment approaches, the research landscape offers real hope for children with IBD. Join us for this candid, informative discussion about protecting children from the worst outcomes of IBD through early intervention, personalized treatment, and collaborative care models that address both physical and mental wellbeing.Links: Research article- Preventing Fistulas and Strictures Among Children with Crohn's DiseaseJournal Article referenced- National Perspectives of Barriers by Insurance and Pharmacy Benefits Managers in Pediatric Inflammatory Bowel DiseaseImproveCareNowLet's get social!!Follow us on Instagram!Follow us on Facebook!Follow us on Twitter!

In this episode, Meredith and Alex dive into a research roundup on essential health topics, including sleep, exercise, diet, and alcohol. They explore the benefits and trade-offs of morning vs. evening exercise, the importance of eating breakfast, the numerous wellness advantages of spending time outdoors, and the impact of community and social connections on overall well-being. Additionally, they discuss alcohol consumption and its effects on diet, sleep, and exercise habits, plus an interesting study on whether alcohol consumers actually exercise more.— The Podcast Couch Dilemma— Life Updates & Meredith's Frostbite— Morning vs. Evening Workouts— The Science Behind the Benefits of Getting Outside— Community and Social Connection— The Importance of Quality Sleep— The Double-Edged Sword of AlcoholResources Mentioned in This Episode:· Listen to Afternoon Snack: Exploring Common Relationships with Food + Alex's Half Ironman!· Listen to Afternoon Snack: Understanding Alcohol: Its Impact on Your Health and Lifestyle· Comparing Morning Exercise to No Exercise· Does Exercise Timing Impact Sleep?· The Bidirectional Relationship Between Diet Quality and Sleep· Do Alcohol Consumers Exercise More?────────────────────────────Want to work with Tactic Functional Nutrition? Check Out Our ServicesLearn More About Us Here and be sure to follow Tactic Nutrition on IG!Stay in the loop with us by signing up for our email list!

In this episode Lewis First, MD, MS, FAAP, editor-in-chief of Pediatrics, is back for “First Up.” He offers an overview of the March issue of the journal.  David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also speak to Doctor Sean O'Leary, MD, MPH, FAAP, chair of the AAP Committee on Infectious Diseases, about the emerging measles crisis in the U.S. and the 2025 vaccine schedule. For resources go to aap.org/podcast.

Hormonal birth control increases breast cancer risk in women with a BRCA1 mutation, but not women with a BRCA2 mutation. Levonorgestrel IUDs increase risk, but how much? The long-term risk of breast cancer coming back — recurring — as metastatic disease has gone down in the last 20 years, but younger women still have a higher risk than older women. What does all this mean? Breastcancer.org Professional Advisory Board member Dr. Kathy Miller discusses the details of these studies and how they may affect you. Listen to the episode to hear Dr. Miller discuss these studies: hormonal birth control ups risk of breast cancer in women with a BRCA1 mutation levonorgestrel IUDs increase risk breastfeeding after breast cancer seems safe the long-term risk of late, distant recurrence has gone down but age affects that risk

In this episode Alex R. Kemper, MD, MPH, MS, FAAP, deputy editor of the journal Pediatrics, offers a bird's-eye view of the February issue. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also talk to AAP President Susan J. Kressly, MD, FAAP, about how to help patients and families affected by Pediatric Acute Onset Neuropsychiatric Syndrome or PANS. For resources go to aap.org/podcast.

In this episode Rachel Moon, MD, FAAP, associate editor of digital media for the journal Pediatrics, shares a research roundup from the January issue. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also talk to Bobbi Byrne, MD, FAAP, and Gary Freed, MD, MPH, FAAP, about pediatricians' income disparities based on sex. For resources go to aap.org/podcast.

Join us as we welcome back Dr. Veera Rajagopal, a discovery scientist at Regeneron with an interest in human genetics and drug target discovery in neuroscience and psychiatry. If you're a regular listener, you may be familiar with Veera's quarterly appearances on the show, where Patrick and he discuss the latest developments in genetics, drug discovery, and precision medicine. Grab yourself a cup of something warm and tune in as Veera and Patrick close out 2024 with a wrap up covering: Population genomics programs New Alzheimer's research The impact of genetics on menopause onset Newborn genetic screening Tune in now, and don't forget to check out Veera's substack, GWAS Stories, and his Twitter, @doctorveera.

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In this episode Lewis First, MD, MS, FAAP, editor-in-chief of Pediatrics, is back for “First Up.” He offers a bird's-eye view of what's in the December issue of the journal. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also speak with Kimberly Montez, MD, MPH, FAAP, about new policy from the AAP urging paid family and medical leave for all families. For resources go to aap.org/podcast.

Send us a textDo psychedelics make people more empathic? Does coming off antidepressants before psychedelic therapy affect outcomes? Can MDMA change your personality? Can a psychedelic medicine without the “trip” still help with depression? In today's episode of the Psychedelic Therapy Frontiers podcast, we discuss recent studies that seek to answer these questions and much more. For those of you who are new to the show, welcome! Psychedelic Therapy Frontiers is brought to you by Numinus and is hosted by Dr. Steve Thayer and Dr. Reid Robison.Learn more about our podcast at https://numinus.com/podcast/Learn more about psychedelic therapy training opportunities at https://numinus.com/training/Learn more about our clinical trials at https://www.numinus.com/clinical-trials Learn more about Numinus at https://numinus.com/Email us at ptfpodcast@numinus.com Follow us on Instagram: https://www.instagram.com/drstevethayer/https://www.instagram.com/innerspacedoctor/https://www.instagram.com/numinushealth/

Today hosts Tiffany and Katja discuss recent research on estrogen's effects on muscle. This is a hot topic at the moment, so in this episode, we share the importance of understanding the background of our hormones and the effect of estrogen on areas like muscle mass, neuromuscular activation, and recovery. Listen in to learn how the effects of estrogen are being studied in research and the different ways that estrogen impacts our muscular tissues. — Show Notes: Background on estrogen's relationship with fascia and tissue [1:59] How is the effect of estrogen on muscle being studied [3:31] Different types of estrogen [8:38] Impact of estrogen on muscles specifically [9:43] Importance of individuality when working with women's bodies [16:29] Impact of estrogen on strength on a molecular level [19:03] Ways that estrogen impacts recovery [24:26] Takeaways [33:41] — Links Mentioned: Watch this episode on YouTube Traditional Chinese Medicine Yoga Teacher Training Female Health Yoga Teacher Training Traditional Chinese Medicine + Female Health Yoga Teacher Training | Tulum, Mexico – March 23-30, 2025 Yoga for Athletes Yoga Teacher Training Connect with Katja Bartsch: Facebook | Instagram | Kalamana Yoga | Yoga Medicine® Online Guest Teacher You can learn more about this episode, and see the full show notes at YogaMedicine.com/podcast-122. And you can find out more about insider tips, online classes or information on our teacher trainings at YogaMedicine.com. To support our work, please leave us a 5 star review with your feedback on iTunes/Apple Podcasts.

In this episode Alex R. Kemper, MD, MPH, MS, FAAP, deputy editor of the journal Pediatrics, offers a bird's-eye view of the November issue. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also speak with Ritu Banerjee, MD, PhD, FAAP, about curbing antibiotic use in agriculture. For resources go to aap.org/podcast.

Join us as we welcome back Dr. Veera Rajagopal, a discovery scientist at Regeneron with an interest in human genetics and drug target discovery in neuroscience and psychiatry. If you're a regular listener of The Genetics Podcast, you may be familiar with Dr. Veera's annual round-up episodes, and more recently, his quarterly appearances on the show. We're pleased to bring you the latest quarterly roundup, during which Dr. Veera and Patrick walk through the most recent developments in genetics, drug discovery, and precision medicine. In this episode, Dr. Veera and Patrick dive into a wide variety of topics, including: - The evolution of skin color in humans - The potential of a novel tau isoform for Alzheimer's treatment - Protective mechanisms of tomoregulin-1 against herpes simplex virus - The discovery of a new noncoding Mendelian disease mechanism linked to cardiac arrhythmias - A comparative analysis of whole genome versus whole exome sequencing for gene discovery. Tune in now, and don't forget to check out Veera's substack, GWAS Stories, and his Twitter, @doctorveera. Additionally, we're excited to invite you to an in-person meetup for The Genetics Podcast during the ASHG Annual Meeting in Denver, CO! Over the years, we've had the honor of speaking with leading voices across science, industry, patient advocacy, and policy. Now, we're bringing this incredible community together face-to-face. Join us on the evening of Thursday, November 7. To RSVP, visit: https://lu.ma/geneticspodASHG.

Now that he's had a chance to digest all of the research presented at ECTRIMS, Dr. Bruce Bebo, the National MS Society's Executive Vice President of Research, is back to share the key research presented at the largest MS research conference in the world. This episode of RealTalk MS is the perfect follow-up to my initial conversation with Bruce, which occurred just minutes after ECTRIMS ended. (If you missed our conversation, you may want to check out Episode 369 of RealTalk MS.) We have a lot to talk about! Are you ready for RealTalk MS??! This Week: Part 2 of our coverage of ECTRIMS 2024  :22 Dr. Bruce Bebo shares the key research presented at ECTRIMS  1:06 Share this episode  26:13 Have you downloaded the free RealTalk MS app?  26:31 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/373 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com RealTalk MS Episode 369: ECTRIMS 2024 with Kristine Werner Ozug and Dr. Bruce Bebo https://realtalkms.com/369 Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200 Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 373 Guest: Dr. Bruce Bebo Privacy Policy

Join Chief U.S. Economist Lara Rhame, Executive Director of Investment Research Andrew Korz and Research Associate Alan Flannigan as they examine their outlooks for equities, credit, real estate and essential macroeconomic trends in Q4.They discuss their view on interest rates, inflation, and the labor market—and how these key macro factors could impact the investment landscape.For more research insights go to FSInvestments.com https://bit.ly/m/fsinvestments

Send us a textBlood Flow Restriction (BFR) training has been used for years to help patients make greater gains during strength training. But does BFR belong in oncology rehab?Short answer: yes!Dr. Kelly Martin, PT, is back on the podcast to discuss the benefits of BFR, plus important safety considerations for our oncology patients. Dr. Martin also shares her experiences using BFR in clinical practice, including protocols, patient responses, and the importance of education and reassurance for patients hesitant to engage in exercise. The conversation highlights the need for more research in this area and the potential for BFR to improve patient outcomes in oncology.Join TheOncoPT Specialization Community here. Today's Research Round-up Article: Blood Flow Restriction in Oncological Patients: Advantages and Safety Considerations _______________Writing your oncology specialty exam case report is a huge undertaking.And it's easy to make silly mistakes that can derail your entire writing process.That's why you need my brand new FREE masterclass: The 3 Step Framework for a Finished Case ReportSave your seat at TheOncoPT.com/frameworkFollow TheOncoPT on Instagram.Follow TheOncoPT on TikTok.Follow TheOncoPT on Twitter.

Today hosts Tiffany and Katja dive into the common misconceptions around breath work and Pranayama. Is breathwork really the new Pranayama? Is deep breathing indeed always better? Does breathwork really need to be intense to work? In this episode, we unpack these and other common misconceptions about Pranayama and breathwork. Listen in to find ways to feel better in your life through a better understanding of Pranayama. — Show Notes: Myth 1: Breathwork is the new pranayama [3:07] Myth 2: The ultimate goal of pranayama is to fully control the breath [9:02] Myth 3: Pranayama must be practiced over long periods of time to see benefits [16:31] Myth 4: Ujjayi and/or deep breathing is a superior technique [22:29] Myth 5: Breathwork involving hyperventilation is life-changing, always [30:36] Myth 6: Only advanced practitioners should do Pranayama [37:31] Myth 7: Pranayama has one magic rhythm/ pattern [41:17] — Links Mentioned: Watch this episode on YouTube Pranayama Yoga Teacher Training Previous Yoga Medicine® Podcast Episodes: 85: Research Roundup: A Stroll Through the Breathwork Landscape 87: The Science of Breathing Less: Research Roundup Connect with Katja Bartsch:          Facebook | Instagram | Kalamana Yoga | Yoga Medicine® Online Guest Teacher You can learn more about this episode, and see the full show notes at YogaMedicine.com/podcast-118. And you can find out more about insider tips, online classes or information on our teacher trainings at YogaMedicine.com. To support our work, please leave us a 5 star review with your feedback on iTunes/Apple Podcasts.

In this episode Rachel Moon, MD, FAAP, associate editor of digital media for the journal Pediatrics, shares a research roundup from the September issue. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also preview the 2024 election for AAP President-elect with statements from candidates Lily J. Lou, MD, FAAP, and Andrew D. Racine, MD, PhD, FAAP. 

The U.S. Preventive Services Task Force updated its screening mammogram recommendations. Having a double mastectomy after being diagnosed with breast cancer in one breast doesn't lower the risk of dying from the disease. Certain types of exercise can reduce the risk of metastatic recurrence and neuropathy caused by chemotherapy.  What does all this mean? Breastcancer.org Professional Advisory Board member Dr. Holly Pederson discusses the details of these studies and how they may affect you. Listen to the episode to hear Dr. Pederson discuss these studies: updated U.S. Preventive Services Task Force breast cancer screening recommendations double mastectomy after a cancer diagnosis in one breast reduces the risk of cancer in the other breast, but doesn't decrease the risk of dying from breast cancer neuromuscular training reduces chemotherapy-induced peripheral neuropathy exercise reduces the risk of metastatic recurrence of hormone receptor-negative breast cancer hormonal therapy doesn't increase dementia risk Scroll down to below the “About the guest” information to read a transcript of this podcast.

In this episode Lewis First, MD, MS, FAAP, editor-in-chief of Pediatrics, is back for “First Up.” He offers a bird's-eye view of what's in the August issue of the journal. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also speak with Elise Sarvas, DDS, MSD, MPH, a board-certified pediatric dentist at Mayo Clinic, about oral health care for youth with developmental disabilities. For resources go to aap.org/podcast.

Send us a Text Message.In this first edition of our special Research Round-Up series, we dive into groundbreaking research that examines a novel way to put adolescent & young adult (AYA) survivors BACK in the driver's seat of their care.Dr. Kelly Martin, physical therapist & TheOncoPT team member, joins Elise to discuss the importance of education and bridging the gap in AYA cancer care by leveraging social media.Even if you despise social media, you DO NOT want to miss this episode because...  ⬇️YOUR PATIENTS ARE ON SOCIAL MEDIA & ARE USING IT TO EDUCATE THEMSELVES.Therefore, it is YOUR responsibility to help your patients find accurate, reliable, helpful education online.To find out where to start, listen to our conversation now! Join TheOncoPT Specialization Community here. Today's Research Round-up Article: Partnering With Social Media Influencers to Equitably Improve Adolescent and Young Adult Cancer Outcomes: A Novel Strategy to Support Cancer Care DeliveryWriting your oncology specialty exam case report is a huge undertaking.And it's easy to make silly mistakes that can derail your entire writing process.That's why you need my brand new FREE masterclass: The 3 Step Framework for a Finished Case ReportSave your seat at TheOncoPT.com/frameworkFollow TheOncoPT on Instagram.Follow TheOncoPT on TikTok.Follow TheOncoPT on Twitter.

Join Chief U.S. Economist Lara Rhame, Director of Investment Research Andrew Korz and Research Associate Alan Flannigan as they examine their outlooks for corporate credit, private equities, commercial real estate and key macroeconomic trends for Q3 2024. They go in depth on the latest impacts of market concentration, stubborn inflation and more, with a look at the causes and potential implications of the optimism currently priced into markets. 

In this episode Alex R. Kemper, MD, MPH, MS, FAAP, deputy editor of the journal Pediatrics, offers a bird's-eye view of the July issue. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also speak with Lisa Abuogi, MD, FAAP, about how to counsel people living with HIV who want to breastfeed their babies. For resources go to aap.org/podcast.

In this episode Rachel Moon, MD, FAAP, associate editor of digital media for the journal Pediatrics, shares a research roundup from the June issue. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also talk to Edith Bracho-Sanchez, MD, FAAP, about her role as host of Healthy Children, a new AAP podcast geared toward parents. For resources go to aap.org/podcast.

In this episode Lewis First, MD, MS, FAAP, editor-in-chief of Pediatrics, is back for “First Up.” He offers a bird's-eye view of what's in the May issue of the journal. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also speak with David Kimberlin, MD, FAAP, editor of the Red Book, about what to expect in the 2024 edition released this month. For resources go to aap.org/podcast.

Welcome to BCI Cattle Chat! In this episode the experts discuss what do when a bull doesn't pass a bull BSE and answer some economic questions. Guest Dannell Kopp also discuss her research about metaphylaxis. Guest: Dannell Kopp, Graduate and Veterinary Student 2:21 Bull BSE 10:47 Economic Questions 14:00 Research Roundup: Metaphylaxis For more on… Continue reading Bull BSE, Economic Questions, Research Roundup: Metaphylaxis

In this episode Alex R. Kemper, MD, MPH, MS, FAAP, deputy editor of the journal Pediatrics offers a bird's-eye view of the April issue. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also speak with Samantha Ahdoot, MD, FAAP, about the effects of global climate change on children's health. For resources go to aap.org/podcast.

In this episode Rachel Moon, MD, FAAP, associate editor of digital media for the journal Pediatrics, shares a research roundup from the March issue. Hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, also talk to Felicitas Livaudais, MD, FAAP, and Cindy Calderon, MD, FAAP, about surviving disasters and learning how to prepare for the future. For resources go to aap.org/podcast.