Podcasts about Pharmacodynamics

In this episode of Onc Now, Jonathan welcomes Ahmad Awada, Head of the Oncology Department at Chirec Cancer Institute in Brussels and Editor in Chief of EMJ Oncology. Together they discuss groundbreaking developments in cancer care, the promise of targeted therapies, and the importance of global collaboration in oncology.  Timestamps:      (00:00)-Introduction  (01:20)-Reflecting on ESMO 2024  (07:37)-Looking ahead to ESMO 2025  (10:04)-Pharmacokinetics and Pharmacodynamics of Antibody-Drug Conjugates  (13:24)-New cytotoxics and molecular targeted therapies for solid tumours   (16:30)-Surgery of primary tumour in de novo metastatic breast cancer  (19:29)-Improving survival in cancer patients  (22:47)-Managing the risk of thromboembolism   (24:43)-Exciting advancements on the horizon   (29:38)-Wishes for oncology  

Drs. Anne-Grete Märtson, Megan Wimmer, and Evan Clemens join Dr. Erin McCreary to tackle the one of the hottest debates among providers taking care of immunocompromised patients, valganciclovir dosing! Learn all about the history of valganciclovir dosing, what is valganciclovir's PK/PD target, and even valganciclovir therapeutic drug monitoring. References: Märtson AG, Edwina AE, Kim HY, Knoester M, Touw DJ, Sturkenboom MGG, Alffenaar JC. Therapeutic Drug Monitoring of Ganciclovir: Where Are We? Ther Drug Monit. 2022 Feb 1;44(1):138-147. doi: 10.1097/FTD.0000000000000925. PMID: 34610621; PMCID: PMC8746890. Wiltshire H, Paya CV, Pescovitz MD, Humar A, Dominguez E, Washburn K, Blumberg E, Alexander B, Freeman R, Heaton N, Zuideveld KP; Valganciclovir Solid Organ Transplant Study Group. Pharmacodynamics of oral ganciclovir and valganciclovir in solid organ transplant recipients. Transplantation. 2005 Jun 15;79(11):1477-83. doi: 10.1097/01.tp.0000164512.99703.ad. PMID: 15940035. This podcast is powered by Pinecast.

In this episode, Ayesha spoke with Howard McLeod, PharmD, Director of the Center for Precision Medicine and Functional Genomics, Professor of Pharmacy and Medicine at Utah Tech University and Precision Medicine Advisor at the Geriatric Oncology Consortium; and Sharmeen Roy, PharmD, Chief Strategy and Science Officer at DoseMe, which is the world's first and largest Bayesian dosing platform designed for clinical practice.Precision dosing, also known as personalized dosing, aims to tailor drug dosages to the individual characteristics of each patient to achieve optimal therapeutic outcomes while minimizing adverse effects. It leverages various patient-specific factors, including genetics, age, weight, organ function and even lifestyle, to determine the most appropriate dosage for each individual. Dr. McLeod is an internationally recognized expert in precision medicine, who has made novel contributions at the discovery, translation, implementation and policy levels. Dr. McLeod received his Doctorate in Pharmacy from the Philadelphia College of Pharmacy and Science and completed his Post-Doctoral Training at St Jude Children's Research Hospital and the University of Glasgow. Dr. Roy is passionate about leveraging technology to amplify the impact of the pharmacist. Her career spans pediatric clinical pharmacy, clinical research and pharmacogenomics with leadership roles at University of Chicago Medical Center and PipelineRx. She received her Doctor of Pharmacy degree from the University of Illinois at Chicago, is a Board-Certified Pharmacotherapy Specialist and completed a Pediatric Specialty Pharmacotherapy Residency at Texas Children's Hospital.Tune into the episode to learn more about the current landscape of precision dosing, including the latest technologies and tools designed to help optimize drug dosages.For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/  Follow Us on Social MediaTwitter: https://twitter.com/Xtalks Instagram: https://www.instagram.com/xtalks/ Facebook: https://www.facebook.com/Xtalks.Webinars/ LinkedIn: https://www.linkedin.com/company/xtalks-webconferences YouTube: https://www.youtube.com/c/XtalksWebinars/featured

We have recently been asked the question, "Are all AAS equal on a mg/mg basis?" Today, Dr Scott Stevenson explores this topic in this lecture. With Scott McNally TIME STAMPS BELOW - Muscle Minds Podcast 156 0:00 Teaser 0:45 Intro 1:30 Are All Steroids Equally Anabolic? 2:30 What is the question exactly? 6:20 Why ask the question? 12:20 Is it likely that all AAS are equal on a mg/mg basis 25:20 Pharmacogenetics and Pharmacodynamics 31:40 AAS Data in Humans 41:30 Supra physiological Test Study 43:50 Deca Study 51:45 Study comparison of multiple AAS 1:05:20 What can we make of this? 1:07:30 Practical dose response curves 1:15:00 Concluding Thoughts on AAS Anabolic Equivalency 1:19:00 Amazing Dog Pics!!

This week we review an episode from 2022 in the world of cardiac surgery and pediatric pharmacology when we review a work from Australia on levels of cefazolin during and after surgery. Is there an optimal dose regimen that will achieve proper MIC levels of drug? What should the goal of therapy be in regards to MIC levels? Are there novel means of dosing cefazolin? We speak with pediatric critical care pharmacy coordinator at Mount Sinai Kravis Children's Hospital, Dr. Jessica Frye for the pharmacist's perspective on some of these important questions.https://doi.org/10.1016/j.athoracsur.2022.02.047

Unit 1 Kinetics and Dynamics 1_7 Pharmacodynamics  This is a free open educational resource I am reading as an audio to make more accessible under Creative Commons Attribution 4.0 International License. While I am a licensed pharmacist, I am not providing any health advice, this is for educational purposes only.  Here's my website: https://www.memorizingpharm.com/  Where you can get the Memorizing Pharmacology: A Relaxed Approach audiobook, possibly for free: https://www.audible.com/pd/Memorizing-Pharmacology-Audiobook/B09JVBHRXK?source_code=AUDFPWS0223189MWT-BK-ACX0-281667&ref=acx_bty_BK_ACX0_281667_rh_us  OER Pharmacology Book Link to download or view the book presented in the video.  https://wtcs.pressbooks.pub/pharmacology/ Want to get in touch with me, tonythepharmacist@gmail.com   

More information about Brain Lenses at brainlenses.com.BL supporters receive an additional episode of the show each week. Info about becoming a supporter at the above address, or at Understandary.com.Read the written version of this episode: This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit brainlenses.substack.com/subscribe

Understanding a novel drug's PK and PD properties begins with nonclinical studies and evolves through early phase clinical trials. In this issue, we take a closer look at the collection and use of PK/PD data in early phase drug development. CHAPTERS: - 0:08 — Introduction to Issue 34 - 1:32 — Nonclinical Studies - 2:39 — IND Requirements and Translation to Clinical PK/PD - 5:37 — Translating Nonclinical Knowledge of PK/PD Analyses to Clinical Study - 8:51 — Case Study - 12:32 — Conclusion Click here to read Issue 34: https://www.altasciences.com/sites/default/files/2023-08/the-altascientist-issue-34-toxicokinetics-pharmacokinetics-and-pharmacodynamics.pdf Introduction on TK, PK, and PD Data: The understanding of a new drug's absorption, distribution, metabolism, and excretion (more commonly known as ADME) is critical to ensure that it is safe for human use. That understanding is achieved through collection and analysis of pharmacokinetic (PK) and pharmacodynamic (PD) data, which together account for approximately 25% of the contents of a drug package insert or label. The characterization of PK/PD effects starts with nonclinical toxicokinetic (TK) studies in animals. The purpose of TK studies is to define the chemical properties of the drug, including pharmacology and toxicology, and to assist in development of downstream clinical protocols. The necessary nonclinical studies are conducted before submission of Investigational New Drug (also known as IND) applications to the FDA or other global regulatory agencies, and deliver critical data used to set the parameters for future clinical trials. About Altasciences: Altasciences is an integrated drug development solution company offering pharmaceutical and biotechnology companies a proven, flexible approach to preclinical and clinical pharmacology studies, including formulation, manufacturing, and analytical services. For over 25 years, Altasciences has been partnering with sponsors to help support educated, faster, and more complete early drug development decisions. Altasciences' integrated, full-service solutions include preclinical safety testing, clinical pharmacology and proof of concept, bioanalysis, program management, medical writing, biostatistics, clinical monitoring, and data management, all customizable to specific sponsor requirements. Altasciences helps sponsors get better drugs to the people who need them, faster.

Host Aaron Lohr talks with two researchers at ENDO 2023, Kyle Horlen, DVM, and Joshua Myers, both from Rani Therapeutics, about two presentations they made about an oral treatment of teriparatide for the treatment of osteoporosis. The two presentations are titled, “Pharmacokinetics (PK) and Pharmacodynamics (PD) of the Parathyroid Hormone Analog PTH (1-34) (Teriparatide) Delivered via an Orally Administered Robotic Pill (RT-102),” and “An Orally Administered Robotic Pill (RP) Reliably And Safely Delivers the Human Parathyroid Hormone Analog hPTH(1-34) (Teriparatide) With High Bioavailability in Healthy Human Volunteers: A Phase 1 Study.” For helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast.

Host Aaron Lohr talks with two researchers at ENDO 2023, Kyle Horlen, DVM, and Joshua Myers, both from Rani Therapeutics, about two presentations they made about an oral treatment of teriparatide for the treatment of osteoporosis. The two presentations are titled, “Pharmacokinetics (PK) and Pharmacodynamics (PD) of the Parathyroid Hormone Analog PTH (1-34) (Teriparatide) Delivered via an Orally Administered Robotic Pill (RT-102),” and “An Orally Administered Robotic Pill (RP) Reliably And Safely Delivers the Human Parathyroid Hormone Analog hPTH(1-34) (Teriparatide) With High Bioavailability in Healthy Human Volunteers: A Phase 1 Study.” Show notes are available at https://www.endocrine.org/podcast/enp73-a-robotic-teriparatide-pill-to-treat-osteoporosis — for helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast

Host Aaron Lohr talks with two researchers at ENDO 2023, Kyle Horlen, DVM, and Joshua Myers, both from Rani Therapeutics, about two presentations they made about an oral treatment of teriparatide for the treatment of osteoporosis. The two presentations are titled, “Pharmacokinetics (PK) and Pharmacodynamics (PD) of the Parathyroid Hormone Analog PTH (1-34) (Teriparatide) Delivered via an Orally Administered Robotic Pill (RT-102),” and “An Orally Administered Robotic Pill (RP) Reliably And Safely Delivers the Human Parathyroid Hormone Analog hPTH(1-34) (Teriparatide) With High Bioavailability in Healthy Human Volunteers: A Phase 1 Study.” Show notes are available at https://www.endocrine.org/podcast/enp73-a-robotic-teriparatide-pill-to-treat-osteoporosis — for helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast

Free pharmacology audiobook if you've never had one with Audible before: https://www.audible.com/pd/Memorizing-Pharmacology-Audiobook/B09JVBHRXK?source_code=AUDFPWS0223189MWT-BK-ACX0-281667&ref=acx_bty_BK_ACX0_281667_rh_us These two words, pharmacokinetics, and pharmacodynamics, get confused; I wanted to put up a quick way to remember the difference. If you want a longer explanation, go to episode 21, pharmacology basics, in the NGN NCLEX Memorizing Pharmacology Playlist.   

Understanding how living cells work is difficult due to the number of varied and complex processes occurring in them. This complexity can be elucidated by breaking these processes down and focusing on a particular mechanism. One approach is to use mathematical equations – the basis of computational modelling. Dr Susan Mertins, the founder and CEO of Biosystem Strategies LLC, in the USA, is exploring how ordinary differential equations and machine learning can be applied to cancer data for biomarker discovery and drug development, leading to improvements in personalised medicine.Read more in Research OutreachRead some of their latest work here: https://doi.org/10.3389/fonc.2021.805592

In this episode, Jonathan is joined by Joubert Gama, a Medical Consultant in the pharmaceutical industry. They discuss their experiences in medical school which they attended together, and Gama provides insights as to what attracted him to working in the pharmaceutical industry with an emphasis on drug development, pharmacodynamics, and clinical affairs including medical regulations and compliance. Gama takes us on a journey of what it takes to bring a drug to market, as well as delving into his surprising appearances on well-known several television series!

https://www.patreon.com/theemttutor This lecture/podcast is part of the Pharmacology Block series. By the end of this lecture, the student should have an understanding of the following: Knowledge Domains: Define the following key terms: Pharmacodynamics, Intended Effects, Indications, Side Effects, Unintended Effects, Untoward Effects, Contraindications Generic versus Trade name medication Enteral versus Parenteral medications Routes of medication administration: Rectal, Oral, Intravenous, Intraosseous, Subcutaneous, Intramuscular, Inhalation, Sublingual, Transcutaneous Forms of medications: Solid, Liquid, Gas The Six Rights of Medication Administration Direct Orders versus Standing Orders Peer-assisted, Patient-assisted and EMT-administered medications Medications used by EMTs – Lecture 1 of the Pharmacology Block Medications administration to pediatrics, geriatrics, and pregnant patients Steps for auto-injector Understanding patient medications (prescribed and OTC) Medication Errors --- Send in a voice message: https://anchor.fm/thepublicsafetyguru/message

Austin Morrison, Infectious Diseases and Antimicrobial Stewardship Clinical Pharmacist at the Moffitt Cancer Center and Research Institute, presents a talk on the pharmacokinetic and pharmacodynamic principles associated with the optimal dosing of antimicrobial agents. Dr. Morrison begins by defining basic antimicrobial concepts, including absorption, distribution, metabolism, and excretion. He then compares and contrasts concentration-dependent versus time-dependent killing as it applies to different antimicrobial classes. Dr. Morrison then specifically singles out beta-lactams and time-dependent killing and the benefits of extended dosing strategies. He also discusses the significance of the AUC/MIC curve. Lastly, Dr. Morrison concludes by discussing antibiotic dosing in renal insufficiency and the ideal strategies for this group of patients.

Pharmacodynamics, medication actions at receptors.

Go to sleep but what else?

Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.thermofisher.com/chemistry-podcast/ to access the extended video version of this episode and the  episode summary sheet, which contains links to recent publications and additional content recommendations for our guest. You can access the extended video version of this episode via our YouTube channel to hear, and see, more of the conversation!Antibiotics are an incredibly important class of drugs and possibly the most impactful, life-changing scientific innovation in history. However, microorganisms reproduce themselves very rapidly and can evolve in literal minutes. We can't iterate science this quickly, which is the basis of increasing cases of antibiotic resistance that are a growing concern in modern medicine. Antibiotics are complex both chemically and in their biological function, which makes them hard to develop and a relatively unattractive pharmaceutical class from the business perspective. Like never before, we need a fresh perspective, and this is where Ziyang Zhang is leaving an impression. Ziyang is young, but incredibly productive and creative. Even before starting with his own research group (soon at Berkley), he has achieved so much and shown incredible chemical talent and thinking unlike anyone else's. His new way of thinking can affect drug development strategies for antibiotics and beyond.This is a captivating discussion with an incredible character, that fascinates with his understated style as he introduces us to his chemistry and his ideas. In a classic BCTL way, we explore his personal and professional path, his research into macrolide antibiotics, and his novel approach to selectively targeting brain cancer.

In this episode, we review the high-yield topic of Pharmacodynamics from the Pharmacology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficialx Twitter: www.twitter.com/medbulletsIn this episode --- Send in a voice message: https://anchor.fm/medbulletsstep1/message

In this episode, Fidelia Bernice, PharmD, and Jennifer Cocohoba, PharmD, share insights on new HIV data from CROI 2022, including:Islatravir tissue and plasma distribution after monthly oral dosingPharmacokinetics, safety, and acceptability of a tenofovir vaginal ringPrEP and Hormone Therapy in Transgender IndividualsAnticholinergic drug effects in older PWHAdherence in PWHPresenters:Fidelia Bernice, PharmDClinical Pharmacy Specialist, Infectious DiseasesDepartment of PharmacyUniversity of Maryland Medical CenterBaltimore, MarylandJennifer Cocohoba, PharmDProfessorDepartment of Clinical PharmacyUniversity of California, San FranciscoSan Francisco, CaliforniaLink to full program:https://bit.ly/3tdkXfJ

We're kicking off a new multi-part series focusing on the pharmacology of cannabis.We're kicking off a new multi-part series focusing on the pharmacology of cannabis.Maybe it's been a while since you were in med school, or you've never been! So in this first episode, we'll focus on the basics of pharmacokinetics (PK), pharmacodynamics(PD), the downstream effects of stimulation, and how that affects the overall function of the endocannabinoid system (ECS).

We're kicking off a new multi-part series focusing on the pharmacology of cannabis.Maybe it's been a while since you were in med school, or you've never been! So in this first episode, we'll focus on the basics of pharmacokinetics (PK), pharmacodynamics(PD), the downstream effects of stimulation, and how that affects the overall function of the endocannabinoid system (ECS).

We're kicking off a new multi-part series focusing on the pharmacology of cannabis.Maybe it's been a while since you were in med school, or you've never been! So in this first episode, we'll focus on the basics of pharmacokinetics (PK), pharmacodynamics(PD), the downstream effects of stimulation, and how that affects the overall function of the endocannabinoid system (ECS).

Show Notes for Episode Twenty of seX & whY: Interview With Dr Shirin Heidari Part 2: Gendro - Advancing Sex and Gender Equity in Science Research Host: Jeannette Wolfe Guest: Shirin Heidari PhD, virologist and experimental oncologist, founding President of Gendro. Part 2 of Interview with Dr Shirin Heidari This podcast focuses on Dr Heidari's work on systematically integrating the variables of sex and gender into different access points along the research pipeline. She helped start an organization called Gendro which is dedicated to this mission.  The three major gatekeeping posts that Gendro and other organizations are targeting are:  1)    Funding Require the inclusion of both male and female animals or justify an exclusion 2)    Ethical Review Boards These boards review research protocols prior to study enrollment to ensure that the researchers have designed their study to meet national and organization protocols designed to protect participants from being involved with unethical or dangerous practices. Traditionally these boards have been an overlooked area to target.   3)    Journals As many medical publishing house multiple journals, if they modify their standardized template to include query about sex and/or gender analyses, they have the power to rapidly change the expectations of authors and peer reviewers surrounding the inclusion of these factors. In addition, we talked about the SAGER guidelines SAGER guidelines a.k.a. Sex and Gender Equity in Research. These guidelines were put together by an international team of researchers in 2015 and geared towards giving researchers, journal editors, peer- reviewers and publishers better tools to include and evaluate the variables of sex and gender in scholarly work. Although the guidelines have increased the awareness and inclusion of these variables, and many journals have now adopted them, there continues to be a significant opportunity for more widespread use. A recent editorial highlights some of the barriers to utilization and possible concerns. Here is a synopsis of some of the remaining barriers.     Perceived Barrier Solution Mandated inclusion will significantly increase overall research costs from enrollment to additional statistical analysis Underscore that several countries have already been successful in tying initial funding with inclusion criteria which suggests that some of resistance is likely due to ingrained culture rather than significant financial barriers. Highlight that some countries have developed new supplemental funding to enhance adoption. *     Journal editors may have significant time and resource limitations that prohibit their ability to formally introduce or monitor SAGER guidelines.    Emphasize that optimizing science requires constant evolution and that as editors they are already well skilled in helping their journal comply with other required updates.  Including SAGER guidelines can enhance the quality of research their journal publishes and in turn enhance its reputation.    In additional, engaging publishers to invest in better science by making system wide changes in both editorial expectations and technical support (see below) could rapidly accelerate adoption. Peer reviewers may feel ill-equipped to evaluate for the proper inclusion of sex and gender in a review due to knowledge gaps in core principles surrounding sex and gender Provide access to available online trainingmodules such as those offered by the Canadian Institutes of Health Research. Enhance diversity training as who is at the table influences policy and priorities. Technical challenges. Many publishers use the same templates across multiple journals which may limit an individual journal's ability to change their own format. Engage editors to encourage publishers to update digital templated formatting to reflect SAGER principles. The inclusion of a requested digital check off page in submission requirements confirming guideline compliance, could serve both as a reminder cue to the author and a screening tool to journal staff to ensure that it is completed prior to forwarding material to reviewer. This would help minimize any additional time the reviewer would need to spend to ensure SAGER compliance.      * As an aside, identifying important sex-based differences in pre-clinical studies may ultimately be quite cost effective as they may lead to the design of more successful and cost-effective clinical trials We also discovered the opportunities to include the variables of sex and gender in COVID vaccine research and here are two important papers that Dr Heidari just published in this area.  A Systemic Review of the Sex and Gender Reporting in Covid-19 Clinical Trials. 75 initial published trials- 24% presented data broken down by sex and only 13% included in their discussion any discussion about potential sex differences. Time for Action: towards an intersectional gender approach to COVID-19 vaccine development and deployment that leaves no one behind.  Take home points from article sex and age-based differences in immunology may influence vaccine dosing/side effects sex based differences may influence gendered associated acceptance and uptake of vaccines (for example if it is known that women get more side effects with a vaccine it may influence another women's readiness to get vaccinated.) sociocultural associated factors can influence vaccine acceptance and uptake it is critical to have meaningful inclusion of gender diverse voices in high level research and policy decisions. This now becomes very relevant as we now know that there are significant sex differences in side effects in the vaccines including increased risk of myocarditis for males in Pfizer and Moderna  (According to a recent Australian study done by their equivalent of the FDA, the Therapeutic Goods Administration (TGA) numbers may occur up to 1 in 10,000 in younger men. Of note, they suggest that chance of getting myocarditis from Covid is likely 8-10x this risk.)  Conversely women are more likely to get increased risk of clotting with the J and J vaccine. Thanks for joining us!

When administering medications to special populations there are certain considerations that the nurse should be aware of. In this episode, we will explore how some normal processes of aging can affect our patients' pharmacokinetics and pharmacodynamics as well as other important consideration when administering medications to the geriatric population. 

Healthcare Professionals Resiliency and Vaccine HesitancyAs the COVID-19 pandemic rages on, healthcare professionals across the nation continue to face extreme challenges as they battle on the frontlines. The mental and emotional toll this pandemic is taking on care providers is enormous. As such, the resiliency of healthcare professionals has come into focus. Organizations are striving to provide support for staff, and reduce the mental and emotional stressors associated with providing care during the pandemic. How can healthcare professionals more effectively deal with the everyday stressors they encounter? How can facilities prioritize the well-being and resiliency of healthcare professionals in the face of the ongoing pandemic? What strategies can healthcare professionals employ in their practice to best care for patients who may be experiencing vaccine hesitancy?Join host Lauren Sauer, and special guests Jacinda Abdul-Mutakabbir, Precious Davis, and Dr. Jasmine Marcelin on this episode of Transmission Interrupted as they discuss topics surrounding healthcare professionals, resiliency and vaccine hesitancy through the lens of the COVID-19 pandemic.Questions or comments for NETEC? Contact us: info@netec.orgFind us on the web: netec.orgGuestsJacinda Abdul-Mutakabbir, PharmD, AAHIVPJacinda Abdul-Mutakabbir is an Assistant Professor of Pharmacy Practice at Loma Linda University. She recently completed her post-graduate fellowship training at the Anti-Infective Research Laboratory at Wayne State University, Detroit, MI, where she will also receive her MPH. She is a graduate of University of Saint Joseph School of Pharmacy and completed her PGY1 Pharmacy Practice Residency as well as her undergraduate studies at Howard University. Dr. Abdul-Mutakabbir's research and practice interests include Pharmacokinetics and Pharmacodynamics of combination therapy in antimicrobial resistant infections, antimicrobial stewardship, and optimal care for people with HIV. In early 2020 she was recognized among the ECCMID “30 under 30” Outstanding Young Scientists in which she was quoted “as a minority woman researcher, I have worked ardently to promote the necessity of women of color in the research arena.” Dr. Abdul-Mutakabbir is an active member of AAHIVM, IDSA, and ASHP and was the chartering president of the Zeta Iota chapter of Kappa Psi at the University of St. Joseph. She joined SIDP as a trainee and looks forward to a long and successful career of practice, research and service in infectious diseases pharmacotherapy. Precious Davis, BSN, MSNPrecious Davis received her Bachelors of Science in Nursing from Nebraska Wesleyan University in 2015, and received her Masters of Science in Nursing Education from Western Governors University in Utah. She previously worked as a nurse at ENCOR/ENHSA managing the care of individuals with developmental disabilities and supervising nursing assistants and medication aides. Precious has worked as a case manager/staff nurse coordinating patient care for high-risk, complex patients at Nebraska Medicine, and recently started working as a nurse case manager at the Specialty Care Center in January 2017.Jasmine Marcelin, MDDr. Marcelin is a Caribbean native born on the island of Dominica. She received her Bachelor of Science degree with a double major in Biology and Chemistry, and a Diploma in Forensic Science at St. Mary's University in Halifax Nova Scotia. She then returned to her second home, Antigua & Barbuda, for medical school at American University of Antigua College of Medicine, after which she then completed Internal Medicine residency followed by Infectious Diseases fellowship at Mayo Clinic in Rochester, Minnesota. During her time at Mayo...

Pharmacokinetics- pharmacodynamics, pharmacogenetics with a nursing twist.

Show Notes for Episode Twenty of seX & whY: Interview With Dr Shirin Heidari Part 1: Sex and Gender Variables in Science Research Host: Jeannette Wolfe Guest: Shirin Heidari PhD, virologist and experimental oncologist, founding President of Gendro. Part 1 of this podcast spotlights the opportunity to do better science by paying more attention to the variables of sex and gender.  Many times, we simply assume that when we study a medical question in a clinical trial that who is in the trial, adequately represents the population of folks who are affected by the condition being studied. When it comes to the consideration of gender, often this is not true. Dr Heidari and her team did  a systemic review that evaluated study participant's gender in HIV research trials, although more than 50% of people who have HIV are women, only 19% of participants in anti-retroviral trials were women. In 1993 the NIH passed the Revitalization Act in which NIH funded studies would be required to study both men and women. A parallel mandate for basic science research passed over 20 years later in 2015. In some ways this is incredibly nonsensical because most of medical research starts out in the basic science lab. If you don't include animals of both sexes, in adequate numbers, from the beginning, you could be later blindsided in an expensive clinical trial by a physiological sex-based differences that could have been picked up earlier.  Even though there has been progress over the past 30 years, Dr Heidari repeatedly makes the case that just because there are guidelines to include males and females in trials, this does not mean that these guidelines are adhered to or adequately enforced. In addition, there is often a large divide between including men and women in a study and doing an appropriate analysis to see what happens to those men and women. Essentially including both men and women isn't all that helpful unless you breakdown your results also by gender. Importantly, the very best studies go even a step further - they include a calculation in the original study design to determine how many men and how many women would need to be included in a study so that if a difference is found that the researchers can be more confident that the difference represents a real finding and not a statistical blip.  Another important point discussed, is the chance for skewing of study results if researchers don't consider the gender breakdown of who drops out of a trial. Although it is not uncommon for studies to have a small number of participants drop out (and this can happen for a bunch of different reasons ranging from side effects to an inconvenient study location) it is uncommon for them to report the gender breakdown of the dropouts. If significantly more women, or men, drop out of a trial this could be a red flag that something else might be going on and hint to potential problems with the study's conclusions.  Our conversation then veered to discussing pharmacokinetics and pharmacodynamics. Pharmacokinetics tells us about how the body influences a drug - specifically how a drug gets absorbed, distributed, and metabolized. Pharmacodynamics, on the other hand, tells us how the drug influences the body. An example I like to use is to compare giving someone a medication to hiring a secret agent. In both cases, there is a break in, a job and an exit. Traditionally it was believed that, outside of extreme differences in body weight, that drugs worked similarly- break in/job/exit - in male and female bodies if the drug did not target a reproductive organ. We now know this default “no sex difference” assumption is not scientifically valid as there are many drugs which work differently in male and female bodies and that these differences have clinical relevancy.  An example of this is a study we discussed on marijuana pharmacokinetics with women requiring far less amount of marijuana to experience the same cognitive effects. In the discussion section of this paper it suggests that previous studies may have under-appreciated this sex-based difference because they often had higher dropout rates in women which likely skewed their final study results. And here is the link to some of the material we discussed surrounding the knowledge gap on pregnancy and pot-smoking and how this gap has caused some pregnant women to reach out to non-traditional resources to get information.  Other studies we mentioned Here is a study that suggests that the gender of the researcher or lab tech may subtly influence research results.  Here is a study that suggests that male and female animals both have similar amounts of hormonal variation. In part two we will discuss possible solutions. 

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Well! Well! Well! This is the last episode of SEASON 1, and topic of the day is "Drug Antagonism" and YES! I kept my promise to talk about Affirmations for New Year too today!! Antagonism can be of many types like Chemical, Physiological and Pharmacological Antagonisms. Then I will also talk about subclassifications like Receptor Antagonism, Competitive, Non Competitive and their subtypes too! But mantra is to make strong Affirmations and try stick to them in 2022!! Talk to you all again with second saga/season of my podcast!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Well! Well! Well! This is the last episode of SEASON 1, and topic of the day is "Drug Antagonism" and YES! I kept my promise to talk about Affirmations for New Year too today!!Antagonism can be of many types like Chemical, Physiological and Pharmacological Antagonisms. Then I will also talk about subclassifications like Receptor Antagonism, Competitive, Non Competitive and their subtypes too!But mantra is to make strong Affirmations and try stick to them in 2022!!Talk to you all again with second saga/season of my podcast!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Well! Well! Well! This is the last episode of SEASON 1, and topic of the day is "Drug Antagonism" and YES! I kept my promise to talk about Affirmations for New Year too today!!Antagonism can be of many types like Chemical, Physiological and Pharmacological Antagonisms. Then I will also talk about subclassifications like Receptor Antagonism, Competitive, Non Competitive and their subtypes too!But mantra is to make strong Affirmations and try stick to them in 2022!!Talk to you all again with second saga/season of my podcast!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.With a good gracious planning to wave 2021 a "CHAO", let us prepare well for new chores in n ew year 2022. In today's episode I will talk about Drug Synergism, its subheads, types, and I will also cover Drug Selectivity, specificity, Therapeutic efficacy, therapeutic Index, (T.I.) , Therapeutic range /Window. All will be clearly described with apt examples, hope you find this verbal talk beneficial!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.With a good gracious planning to wave 2021 a "CHAO", let us prepare well for new chores in n ew year 2022. In today's episode I will talk about Drug Synergism, its subheads, types, and I will also cover Drug Selectivity, specificity, Therapeutic efficacy, therapeutic Index, (T.I.) , Therapeutic range /Window. All will be clearly described with apt examples, hope you find this verbal talk beneficial!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. With a good gracious planning to wave 2021 a "CHAO", let us prepare well for new chores in n ew year 2022. In today's episode I will talk about Drug Synergism, its subheads, types, and I will also cover Drug Selectivity, specificity, Therapeutic efficacy, therapeutic Index, (T.I.) , Therapeutic range /Window. All will be clearly described with apt examples, hope you find this verbal talk beneficial!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.With the winters setting. in, I will be beginning today's episode in a poetic way and finally I will be setting up introduction to Dose Response relation/curves. Today I will cover the shape, importance of log DRC and its significance. I will be discussing three important aspects in this context namely Drug Potency, Drug Efficacy and Slope of DRC with apt examples and descriptions.Finally with a little talk about my two new highlights and ventures, I will be winding my weekend discussions , hope you all like it!!My patreon page link: https://www.patreon.com/ispharmacology My teespring store:  https://my-store-c35101.creator-spring.com/ For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Today is a great Sunday as I am going to mark the end of receptor tale by discussing mainly two heads, namely No Receptor Mechanisms of Drug Action and also a few Receptor Pathologies. It will be a very informative talk and will be of great value at the same time great relief to pave the way to begin a new topic after today!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Marking the beginnings of today's episode, narrating the glory and essence of a LIBRARY, I will be talking about the Regulation of receptors. I will thoroughly explain the terms up regulation and down regulation of receptors. I will also talk about connected terms like supersensitivity and desensitisation of receptors. Mechanism. consequences and examples of all these phenomena will be detailed. Hope you all find this episode of great importance and value.... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Marking the beginnings of today's episode, narrating the glory and essence of a LIBRARY, I will be talking about the Regulation of receptors. I will thoroughly explain the terms up regulation and down regulation of receptors. I will also talk about connected terms like supersensitivity and desensitisation of receptors. Mechanism. consequences and examples of all these phenomena will be detailed. Hope you all find this episode of great importance and value.... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Marking the beginnings of today's episode, narrating the glory and essence of a LIBRARY, I will be talking about the Regulation of receptors. I will thoroughly explain the terms up regulation and down regulation of receptors. I will also talk about connected terms like supersensitivity and desensitisation of receptors. Mechanism. consequences and examples of all these phenomena will be detailed. Hope you all find this episode of great importance and value.... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.HAPPY DIWALI TO ALL!!In today's episode , I will be talking about enzyme linked and JAK-STAT Transmembrane receptors along with cytoplasmic and nuclear receptors.Season 1 coming to end, BUTBOOK OF SEASON 1 IS ON AMAZONGet your copy at:E-BOOK: https://www.amazon.in/dp/B09KQP36CRPaperback: https://www.amazon.com/dp/B09KN7Y9LKHardcover: https://www.amazon.com/dp/B09KNCWP1DFor all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.HAPPY DIWALI TO ALL!!In today's episode , I will be talking about enzyme linked and JAK-STAT Transmembrane receptors along with cytoplasmic and nuclear receptors.Season 1 coming to end, BUT BOOK OF SEASON 1 IS ON AMAZONGet your copy at:E-BOOK: https://www.amazon.in/dp/B09KQP36CRPaperback: https://www.amazon.com/dp/B09KN7Y9LKHardcover: https://www.amazon.com/dp/B09KNCWP1D For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. HAPPY DIWALI TO ALL!! In today's episode , I will be talking about enzyme linked and JAK-STAT Transmembrane receptors along with cytoplasmic and nuclear receptors. Season 1 coming to end, BUT BOOK OF SEASON 1 IS ON AMAZON Get your copy at: E-BOOK: https://www.amazon.in/dp/B09KQP36CR Paperback: https://www.amazon.com/dp/B09KN7Y9LK Hardcover: https://www.amazon.com/dp/B09KNCWP1D For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode,I comment upon the details, structure and mechanism of Receptors which exist as ion channels. They have a special 5 subunit rosette structure ans function primarily via primary ligand modulation which binds to alpha subunit of the channel. For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.As a continuation of yester episode, today i will be discussing the three major effector pathways of G Protein Coupled Receptor , firstly the Adenylyl cyclase enzyme-cAMP pathway,  then IP3-DAG Pathway, Ion channel regulation,...All will be explained with apt examples and details! Termination of pathways forms a major notable point to discuss, never to be missed.. Wishing you all a very Happy Sunday!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via - https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode I will narrate the famous poem "Windows" by Wes Magee, communicate its amazing message and look into the window of today's topic i.e. G Protein coupled receptors.First and foremost a little word about the receptor nature and types, and then all about G protein coupled receptors, their structure, mechanism introduction and a teaser of upcoming episode too! All in all a good weekend diary to listen to! Hope you all like it........ For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I will be talking about Receptor drug occupation concept or rather to elaborate dual receptor nature! Receptor exists in two forms, "Ra" and "Ri". On this basis I will define Affinity and Efficacy concept which will further help to understand better the terms like Agonists, Antagonist, Partial Agonist and Inverse Agonist. It really gonna be very interesting and informative to dive in this concept to understand the functioning of neurotransmitters. With signature remarks about Faith and Belief I am gonna pen down this enunciation of the day!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Wish you all a very happy international podcast day! Its for both listeners and creators. Together they ROCK!! Together they make podcast happen. Embellishing today's content with decor of sensible stats, I am thankful to all of you! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

This episode was originally released in April 2019 on From the Head of the Bed… a podcast for the anesthesia community.  In this podcast, Skyler walks us through the pharmacodynamics of volatile anesthetics. We talk extensively about the concepts related to minimum alveolar concentration (MAC), the mechanism of action of volatile anesthetics and the physiologic […]

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Essence of Friendship is in "Sincerity" and "Frankness" of thoughts and words, else it becomes senseless.Today's dialogue is all about Receptor mechanisms of drug action. Actually we are starting it! Initially I will talk about about definition of receptors, and a few more terms to comment upon and define to ge to furnish our concepts and understanding of the detailed theory of receptor action mechanism in a smooth and wonderful way. Future holds diving in depth of the subject, so its always good to get acquainted with the Vocabulary, it really helps to enrich one's knowledge!! With dialogue about receptor, agonist , antagonist, partial agonist and ligand, I will be building up the vocabulary to understand the future details nicely! Pointing to the noise of ticking clock, I will be wrapping up to avoid further confusions and strains, , Always keep in mind, "Early to rise gonna make you real wise"!!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via - https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. First and Foremost, a little update from my end is to VOTE FOR MY PODCAST AT- https://www.community.hubhopper.com/hubhopper-awards For my podcast in "EDUCATIONAL PODCAST" Category. A little great expectations, a little request, always remember- One good deed deserves another!! Hope you all VOTE! Today's episode is all about Ion Channels, especially I will talk about Voltage gated Ion Channels(VOC). After discussing the mechanism and examples, I will be talking a word about Transporters too and their mechanism and examples!! Then I will wrap up the episode by last call for voting!(deadline 26th September) For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.First and Foremost, a little update from my end is toVOTE FOR MY PODCAST AT-https://www.community.hubhopper.com/hubhopper-awardsFor my podcast in "EDUCATIONAL PODCAST" Category.A little great expectations, a little request, always remember- One good deed deserves another!!Hope you all VOTE!Today's episode is all about Ion Channels, especially I will talk about Voltage gated Ion Channels(VOC). After discussing the mechanism and examples, I will be talking a word about Transporters too and their mechanism and examples!! Then I will wrap up the episode by last call for voting!(deadline 26th September)For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.First and Foremost, a little update from my end is toVOTE FOR MY PODCAST AT-https://www.community.hubhopper.com/hubhopper-awards For my podcast in "EDUCATIONAL PODCAST" Category.A little great expectations, a little request, always remember- One good deed deserves another!!Hope you all VOTE!Today's episode is all about Ion Channels, especially I will talk about Voltage gated Ion Channels(VOC). After discussing the mechanism and examples, I will be talking a word about Transporters too and their mechanism and examples!! Then I will wrap up the episode by last call for voting!(deadline 26th September)For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Firstly its my great pleasure to wish all a very "HAPPY TEACHER'S DAY". Its a great day and yes I am here with a great discussion topic i.e. Enzyme Inhibition. First of all I will define as a ritual, then with no delay I will discuss its two main types, namely Competitive and Non Competitive Enzyme Inhibition. I will discuss their main features or characteristics, the basic mechanism and yes never to miss, never to forget the wonderful examples!For your utter knowledge, i want to state that Competitive Enzyme inhibition is again of two different kinds, namely Equilibrium and Non equilibrium type and they have their own properties, you need to know them all!The status of Km and Vmax changes for all types and thats worth noticing and remembering, in the end with glory and hail to all preachers and teachers, I will be winding and ending for the great fun filled Sunday! Hope you had a real nice one! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. Firstly its my great pleasure to wish all a very "HAPPY TEACHER'S DAY". Its a great day and yes I am here with a great discussion topic i.e. Enzyme Inhibition. First of all I will define as a ritual, then with no delay I will discuss its two main types, namely Competitive and Non Competitive Enzyme Inhibition. I will discuss their main features or characteristics, the basic mechanism and yes never to miss, never to forget the wonderful examples! For your utter knowledge, i want to state that Competitive Enzyme inhibition is again of two different kinds, namely Equilibrium and Non equilibrium type and they have their own properties, you need to know them all! The status of Km and Vmax changes for all types and thats worth noticing and remembering, in the end with glory and hail to all preachers and teachers, I will be winding and ending for the great fun filled Sunday! Hope you had a real nice one! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Firstly its my great pleasure to wish all a very "HAPPY TEACHER'S DAY". Its a great day and yes I am here with a great discussion topic i.e. Enzyme Inhibition. First of all I will define as a ritual, then with no delay I will discuss its two main types, namely Competitive and Non Competitive Enzyme Inhibition. I will discuss their main features or characteristics, the basic mechanism and yes never to miss, never to forget the wonderful examples!For your utter knowledge, i want to state that Competitive Enzyme inhibition is again of two different kinds, namely Equilibrium and Non equilibrium type and they have their own properties, you need to know them all!The status of Km and Vmax changes for all types and thats worth noticing and remembering, in the end with glory and hail to all preachers and teachers, I will be winding and ending for the great fun filled Sunday! Hope you had a real nice one! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Dr. Lance McMahon is Chair of the Department of Pharmacodynamics at University of Florida College of Pharmacy, a college that has been at the forefront of kratom research. Dr. McMahon studies the mechanism of action of the multiple kratom alkaloids and how they function alone and in concert on our various brain receptors. His lab … 59. Dr. Lance McMahon, Chair of University of Florida College of Pharmacy Dept of Pharmacodynamics Read More » The post 59. Dr. Lance McMahon, Chair of University of Florida College of Pharmacy Dept of Pharmacodynamics first appeared on Kratom Science.

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode I will be further stating the essence of Pharmacodynamics especially the introductory part! Initially I will be stating various drug mechanisms like Activation, Inhibition, Complexation and Neutralisation. All discussion is supported with examples, then I will tell most importantly that Drug mechanism can be receptor or non receptor mediated. Then I will start off with Elaborations about Enzymes, very detailed and specific conversations about Enzyme Stimulation and Enzyme Induction, their essence and differences. All this talk will be the meat and potatoes of today's verbal session. Withdrawing my words after enlisting important enzyme inducers, I promise to continue in next episode, not making too much of the talk just for the sake of few minutes, hoping a magnificent, spiritual Thursday for all!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via - https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode I will be further stating the essence of Pharmacodynamics especially the introductory part!Initially I will be stating various drug mechanisms like Activation, Inhibition, Complexation and Neutralisation. All discussion is supported with examples, then I will tell most importantly that Drug mechanism can be receptor or non receptor mediated.Then I will start off with Elaborations about Enzymes, very detailed and specific conversations about Enzyme Stimulation and Enzyme Induction, their essence and differences.All this talk will be the meat and potatoes of today's verbal session.Withdrawing my words after enlisting important enzyme inducers, I promise to continue in next episode, not making too much of the talk just for the sake of few minutes, hoping a magnificent, spiritual Thursday for all!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links via - https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode I will be further stating the essence of Pharmacodynamics especially the introductory part!Initially I will be stating various drug mechanisms like Activation, Inhibition, Complexation and Neutralisation. All discussion is supported with examples, then I will tell most importantly that Drug mechanism can be receptor or non receptor mediated.Then I will start off with Elaborations about Enzymes, very detailed and specific conversations about Enzyme Stimulation and Enzyme Induction, their essence and differences.All this talk will be the meat and potatoes of today's verbal session.Withdrawing my words after enlisting important enzyme inducers, I promise to continue in next episode, not making too much of the talk just for the sake of few minutes, hoping a magnificent, spiritual Thursday for all!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links via - https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I will be introducing Pharmacodyamics, definition, concept, and try to cover as one line statement, two line statement!!To begin with, today's little contemplation about Criticism, how big deal is it?, how important and wisely you can deal with it, is it really worth a panic? and much more!!And then as our topic proceeds, we will talk about the important drug actions like stimulation, depression, cytotoxicity, replacement, etc.And later I will cover important sites of drug action like Extracellular, Cellular and Intracellular!With these little but important concepts and knowledge bytes, I will be wrapping up with a great tip to be generous with praise and cautious with criticism, and pray and wow never to be trapped in either one!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. In today's episode, I will be introducing Pharmacodyamics, definition, concept, and try to cover as one line statement, two line statement!! To begin with, today's little contemplation about Criticism, how big deal is it?, how important and wisely you can deal with it, is it really worth a panic? and much more!! And then as our topic proceeds, we will talk about the important drug actions like stimulation, depression, cytotoxicity, replacement, etc. And later I will cover important sites of drug action like Extracellular, Cellular and Intracellular! With these little but important concepts and knowledge bytes, I will be wrapping up with a great tip to be generous with praise and cautious with criticism, and pray and wow never to be trapped in either one!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via https://linktr.ee/ispharmacologydifficult

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I will be introducing Pharmacodyamics, definition, concept, and try to cover as one line statement, two line statement!!To begin with, today's little contemplation about Criticism, how big deal is it?, how important and wisely you can deal with it, is it really worth a panic? and much more!!And then as our topic proceeds, we will talk about the important drug actions like stimulation, depression, cytotoxicity, replacement, etc.And later I will cover important sites of drug action like Extracellular, Cellular and Intracellular!With these little but important concepts and knowledge bytes, I will be wrapping up with a great tip to be generous with praise and cautious with criticism, and pray and wow never to be trapped in either one!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult

In this episode Dr. Guerra provides the overview of Pharmacodynamics . --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

Welcome back to the latest instalment from Medic in The Middle, todays episode on is on Asthma, and we are going to be covering; -Asthma definition -Management of asthma -Asthma pathophysiology  -Pharmacodynamics of drugs used in emergency management -Considerations for cardiac arrest Enjoy! Music performed and written by Thomas Alderson

Details of drugs components

Can smoking affect psychotropic levels? What are the two antipsychotics most commonly affected by smoking? Which is the antidepressant most commonly affected by smoking? Faculty: Joji Suzuki, M.D. Hosts: Jessica Diaz, M.D. ; Flavio Guzman, M.D. Learn more about Premium Membership here Earn 1 CME- "The Clinical Guide to Tobacco Use Disorder" Watching out for Tobacco–Drug Interactions: Pharmacokinetics, Pharmacodynamics and Deinduction

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, if you are wondering what are the most broad and basic divisions of the subject Pharmacology, you will find it all in today's episode. Broadly, Pharmacology can be divided into Pharmacodynamics and Pharmacokinetics. Pharmacodynamics covers all details and lets us know ," What the drug does to the body?" On the other hand, Pharmacokinetics is the ADME study, it covers complete drug movement inside the body, telling about all the four processes in detail, Absorption, Distribution , Metabolism and Excretion. All in all, we get to know, "What body does to the drug?" With the help of two examples for each of these divisions, I will clearly describe the whole description and points. After telling you all about these broad pharmacological divisions, I will be throwing light on the Golden connection of Pharmaceutics, Pharmacokinetics, Pharmacodynamics and Pharmacotherapeutics. Its a chain connection step by step with a wonderful description so that you can memorize nicely and understand. fully. On this point of discussion, your query is definite to arise about other branches discussion which you know or you have. ever heard about. Well, no worries, with a promise to lighten up next school of thought with details about other branches, I will humbly depart today. For all updates and latest episodes, please visit www.ispharmacologydifficult.com. You can follow me on social media handles like twitter, insta, facebook and linkedin all with same names"Is Pharmacology Difficult". If you are listening for the first time, do follow me here on your favourite platform, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, if you are wondering what are the most broad and basic divisions of the subject Pharmacology, you will find it all in today's episode. Broadly, Pharmacology can be divided into Pharmacodynamics and Pharmacokinetics. Pharmacodynamics covers all details and lets us know ," What the drug does to the body?" On the other hand, Pharmacokinetics is the ADME study, it covers complete drug movement inside the body, telling about all the four processes in detail, Absorption, Distribution , Metabolism and Excretion. All in all, we get to know, "What body does to the drug?" With the help of two examples for each of these divisions, I will clearly describe the whole description and points. After telling you all about these broad pharmacological divisions, I will be throwing light on the Golden connection of Pharmaceutics, Pharmacokinetics, Pharmacodynamics and Pharmacotherapeutics. Its a chain connection step by step with a wonderful description so that you can memorize nicely and understand. fully. On this point of discussion, your query is definite to arise about other branches discussion which you know or you have. ever heard about. Well, no worries, with a promise to lighten up next school of thought with details about other branches, I will humbly depart today. For all updates and latest episodes, please visit www.ispharmacologydifficult.com. You can follow me on social media handles like twitter, insta, facebook and linkedin all with same names"Is Pharmacology Difficult". If you are listening for the first time, do follow me here on your favourite platform, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!

Welcome all to IS PHARMACOLOGY DIFFICULT Podcast ! I am Dr Radhika Vijay, if you are wondering what are the most broad and basic divisions of the subject Pharmacology, you will find it all in today's episode. Broadly, Pharmacology can be divided into Pharmacodynamics and Pharmacokinetics. Pharmacodynamics covers all details and lets us know ," What the drug does to the body?" On the other hand, Pharmacokinetics is the ADME study, it covers complete drug movement inside the body, telling about all the four processes in detail, Absorption, Distribution , Metabolism and Excretion. All in all, we get to know, "What body does to the drug?" With the help of two examples for each of these divisions, I will clearly describe the whole description and points. After telling you all about these broad pharmacological divisions, I will be throwing light on the Golden connection of Pharmaceutics, Pharmacokinetics, Pharmacodynamics and Pharmacotherapeutics. Its a chain connection step by step with a wonderful description so that you can memorize nicely and understand. fully. On this point of discussion, your query is definite to arise about other branches discussion which you know or you have. ever heard about. Well, no worries, with a promise to lighten up next school of thought with details about other branches, I will humbly depart today. For all updates and latest episodes, please visit www.ispharmacologydifficult.com. You can follow me on social media handles like twitter, insta, facebook and linkedin all with same names"Is Pharmacology Difficult". If you are listening for the first time, do follow me here on your favourite platform, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!

In this episode, we discuss the mechanisms of burning with propofol infusion and explore the evidence behind strategies like mixing lidocaine with propofol.  Our guest today is Dr. Stu Forman, Professor of Anesthesiology at Massachusetts General Hospital. He is an investigator on several NIH-sponsored basic research grants and co-director of the Harvard Anesthesia Research Training Fellowship. Connect with us @DepthAnesthesia on Twitter or email us at depthofanesthesia@gmail.com. Thanks for listening! Please rate us on iTunes and share with your colleagues.  Music by Stephen Campbell, MD.  -- References Bengalorkar GM, Bhuvana K, Sarala N, Kumar T. Fospropofol: clinical pharmacology. J Anaesthesiol Clin Pharmacol. 2011 Jan;27(1):79-83. PMID: 21804712; PMCID: PMC3146164. Dajun Song, Mohamed A. Hamza, Paul F. White, Stephanie I. Byerly, Stephanie B. Jones, Amy D. Macaluso; Comparison of a Lower-lipid Propofol Emulsion with the Standard Emulsion for Sedation during Monitored Anesthesia Care. Anesthesiology 2004; 100:1072–1075 doi: https://doi.org/10.1097/00000542-200405000-00007 Euasobhon P, Dej-Arkom S, Siriussawakul A, Muangman S, Sriraj W, Pattanittum P, Lumbiganon P. Lidocaine for reducing propofol-induced pain on induction of anaesthesia in adults. Cochrane Database Syst Rev. 2016 Feb 18;2(2):CD007874. doi: 10.1002/14651858.CD007874.pub2. PMID: 26888026; PMCID: PMC6463799. Fischer MJ, Leffler A, Niedermirtl F, Kistner K, Eberhardt M, Reeh PW, Nau C. The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors. J Biol Chem. 2010 Nov 5;285(45):34781-92. doi: 10.1074/jbc.M110.143958. Epub 2010 Sep 7. PMID: 20826794; PMCID: PMC2966094. Jalota L, Kalira V, George E, Shi YY, Hornuss C, Radke O, Pace NL, Apfel CC; Perioperative Clinical Research Core. Prevention of pain on injection of propofol: systematic review and meta-analysis. BMJ. 2011 Mar 15;342:d1110. doi: 10.1136/bmj.d1110. PMID: 21406529. Klement W, Arndt JO. Pain on i.v. injection of some anaesthetic agents is evoked by the unphysiological osmolality or pH of their formulations. Br J Anaesth. 1991 Feb;66(2):189-95. doi: 10.1093/bja/66.2.189. PMID: 1817619. Sahinovic MM, Struys MMRF, Absalom AR. Clinical Pharmacokinetics and Pharmacodynamics of Propofol. Clin Pharmacokinet. 2018;57(12):1539-1558. doi:10.1007/s40262-018-0672-3 Scott RP, Saunders DA, Norman J. Propofol: clinical strategies for preventing the pain of injection. Anaesthesia. 1988 Jun;43(6):492-4. doi: 10.1111/j.1365-2044.1988.tb06641.x. PMID: 3261547.

In thirteen episode of the Personalized Medicine Podcast we focus on the personalization oftreatment in clinical practice. There is mourning evidence that shows that variations in thegenome can significantly affect inter-patient differences in drug response. Together with AmaniSaini, the founder of Adverse Drug Reaction (ADR) Canada, we talk about the field ofpharmacogenomics, adverse drug reactions and the future of tailored therapy. Amani holds aBA in Political Science from the University of British Columbia and Master of PublicAdministration degree from Dalhousie University. She currently serves as president of ADRCanada, which brings together patients, researchers, and policymakers to advocate for theincreased the use of genomics in guiding health decisions.Together with Amani, we talked about: ◦ The start-up story of ADR Canada ◦ The burden of adverse drug reactions ◦ The effectiveness of clinical trials ◦ Known gene variants that influence responses to drugs ◦ Genomics as a tool to prescribe effective, safe medications ◦ Advances in pharmacogenomics around the world ◦ The benefit of mandatory healthcare databases ◦ Improving reporting structures in healthcare ◦ The policy proposals of ADR Canada ◦ Turning scientific discovery into clinical practice ◦ The stakeholders in healthcare policy ◦ Future plans for ADR Canada ◦ Science communication, education, collaboration ◦ The future of pharmacogenomicsGet in touch with Amani:Twitter: @amani_sainiTwitter (Adverse Drug Reaction Canada): @adr_canadaWeb (Adverse Drug Reaction Canada): https://adrcanada.orgMake sure to download the full show notes with our guest's bio, links to their most notable work, and our recommendations for further reads on the topic of the episode at pmedcast.com

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.20.106096v1?rss=1 Authors: Canchy, L., Girardeau, P., Durand, A., Vouillac-Mendoza, C., Ahmed, S. H. Abstract: Cocaine is known to increase brain dopamine at supranormal levels in comparison to alternative nondrug rewards. According to the dopamine hypothesis of addiction, this difference would explain, at least in part, why the latter are eventually given up in favor of continued cocaine use during the transition to addiction. Though resting on solid neuroscientific foundations, this hypothesis has nevertheless proven difficult to reconcile with research on cocaine choice in experimental animals. When facing a choice between an intravenous bolus of cocaine and a nondrug alternative (e.g., sweet water), both delivered immediately after choice, rats do not choose the drug, as would be predicted, but instead develop a strong preference for the nondrug alternative, sometimes to the exclusion of continued drug use. Here we report converging evidence that reconciles this finding with the dopamine hypothesis of addiction. Briefly, our data suggest that cocaine is indeed supranormal in reward magnitude, as postulated by the dopamine hypothesis of addiction, but is less preferred during choice because its pharmacokinetics makes it an inherently more delayed reward than the alternative. Reframing previous drug choice studies in rats as intertemporal choice studies reveals that the discounting effects of delays spare no rewards, including supranormal ones, and that during choice, pharmacokinetics trumps pharmacodynamics. Finally, this study also reveals important gaps in our understanding of drug reward delays that need to be filled by future experimental and theoretical work. Copy rights belong to original authors. Visit the link for more info

Pathopharmacology lecture 05/14

Pharmacodynamics

Moderator: James P. Rathmell, M.D. Participants: Michel M. R. F. Struys, M.D., Ph.D. and Jamie W. Sleigh, M.D. Articles Discussed: Population Pharmacodynamics of Propofol and Sevoflurane in Healthy Volunteers Using a Clinical Score and the Patient State Index: A Crossover Study The Art of General Anesthesia: Juggling in a Multidimensional Space Transcript

This week's episode is our second 'co-branded' episode with the SADS Foundation (SADS.ORG) and we speak with the founder and director of Crediblemeds.org, Professor of Medicine Ray Woosley of the University of Arizona. Dr. Woosley speaks with us about how he started the first website dedicated to assessing the evidence for drugs' impact on the QT interval establishing a reliable and trusted website for clinicians and patients to visit to learn about possible drug interactions and their impact on LQTS and the QT interval in general. How was the site first conceived? What are the latest changes on the site? What are the plans for this work going forward? Is grapefruit juice really dangerous? Why does the site request that all have to sign up to access the site? Professor Woosley provides all the answers and more this week!

This week's episode is our second 'co-branded' episode with the SADS Foundation (SADS.ORG) and we speak with the founder and director of Crediblemeds.org, Professor of Medicine Ray Woosley of the University of Arizona. Dr. Woosley speaks with us about how he started the first website dedicated to assessing the evidence for drugs' impact on the QT interval establishing a reliable and trusted website for clinicians and patients to visit to learn about possible drug interactions and their impact on LQTS and the QT interval in general. How was the site first conceived? What are the latest changes on the site? What are the plans for this work going forward? Is grapefruit juice really dangerous? Why does the site request that all have to sign up to access the site? Professor Woosley provides all the answers and more this week!

In this episode, Skyler walks us through the pharmacodynamics of volatile anesthetics. We talk extensively about the concepts related to minimum alveolar concentration (MAC), the mechanism of action of volatile anesthetics and the physiologic response to volatiles. You don’t want … #47 – Pharmacodynamics of Volatile Anesthetics – Skyler Rouhselang, BSN, SRNA Read More »

Jane and Dan caught up with Professor Jason Roberts, NHMRC Practitioner Fellow at The University of Queensland and Consultant Clinical Pharmacist at the Royal Brisbane and Women’s Hospital. Jason is a senior member of the Burns Trauma and Critical Care Research Centre within the University of Queensland Centre for Clinical Research and is Director of the Centre for Translational Anti-infective Pharmacodynamics in School of Pharmacy where he is also Chair of the research Strategies Committee.  We could have talked to Jason all day. In part two of our two-part discussion on pharmacokinetic modelling of antimicrobials we talk about: different pharmacodynamic models for antimicrobials: concentration, time and AUC dependant  the clinical evidence for using pharmacokinetic and pharmacodynamic modelling future directions for clinical pharmacokinetics

Jane and Dan caught up with Professor Jason Roberts, NHMRC Practitioner Fellow at The University of Queensland and Consultant Clinical Pharmacist at the Royal Brisbane and Women’s Hospital. Jason is a senior member of the Burns Trauma and Critical Care Research Centre within the University of Queensland Centre for Clinical Research and is Director of the Centre for Translational Anti-infective Pharmacodynamics in School of Pharmacy where he is also Chair of the research Strategies Committee.  We could have talked to Jason all day. In part one of our two-part discussion on pharmacokinetic modelling of antimicrobials we talk about: Jason's pathway to a research career and the projects that his team are currently working on The patients and pathogens that benefit from individualised dosing of antimicrobials The narrowing therapeutic indices of some antimicrobials Some under-recognised adverse effects of beta-lactam antibiotics how to apply pharmacokinetics and individualised dosing in everyday practice

Narcan and Synthetic Opioids: vive la résistance? Probably not. Read this absolutely brilliant piece from The Tox & The Hound here. (They did all the hard work and we stole their sources.) Opioid "resistance" to naloxone is most likely not a thing, per se. The reported effect from synthetic and novel opioids are unlikely to be due to the agent's binding affinity for receptors within the brain, but rather from an ability to rapidly permeate the blood brain barrier much faster than "traditional" opioids such as heroin. Even in cases where a synthetic opioid agent was identified, the vast majority of cases did not need more than 4mg of naloxone to achieve reversal. Synthetic opioids don't bind any more "tightly" to receptors than naloxone. Synthetic opioids will usually cross the blood brain barrier faster than traditionally encountered agents. Most available evidence shows that synthetic opioid toxicity does not require significantly more naloxone to achieve clinically significant effect. Ergo, the traditional serial naloxone dosing algorithm does not need much modification. 0.04mg -> 0.4mg -> 2mg -> 4mg -> 8mg -> 10mg Not all that "overdoses" is an opioid. Consider all other causes of altered mental status or coma. Namely: hypothermia, hypoxia, and hypercarbia. Acidosis may potentiate the effect of opioids, highlighting the demand for timely and effective ventilation. Polypharmacy or adulteration is increasingly common. Consider intoxication by additional agents. Anchoring bias is a dangerous phenomenon: don't get burned! The Nose Knows. Or does it? Intranasal (IN) naloxone is popular among many EMS agencies as well as law enforcement, fire departments, and bystanders. IN naloxone has been shown to be effective in several randomized controlled trials for successful reversal of opioid intoxication. However... There are important pitfalls to be cognizant of when choosing this option for delivering naloxone.  Intranasal naloxone has poor bioavailability when compared to IV or IM dosing, so higher doses may be required to achieve clinical effect. This is further potentiated by the maximum volume able to be absorbed by the nasal mucosa (around 0.5mL). Patients administered intranasal naloxone may have a variable or delayed response in achieving reversal. Protect Ya Neck Standard isolation precautions are adequate protection against the overwhelming majority of overdose scenes. In the rare instance where respiratory or splash exposure is a concern, a properly fitted N95 mask and goggles will be sufficient. To date, there has yet to be a laboratory confirmed case where a first responder or emergency healthcare provider has suffered a clinically significant opioid intoxication (bradypnea, hypoxia ) as the result of an occupational exposure to fentanyl or its analogues. TotalEM Podcast: https://www.totalem.org/emergency-professionals/podcast-73-ppe-in-opiate-overdoses References 1) Wax, P. M., Becker, C. E., & Curry, S. C. (2003). Unexpected “gas” casualties in Moscow: A medical toxicology perspective. Annals of Emergency Medicine, 41(5), 700–705. https://doi.org/10.1067/mem.2003.148 2) Stolbach, A. (2018). Is This Anything? Naloxone-resistant opioids. Retrieved from https://emcrit.org/toxhound/is-this-anything/ 3) Sutter, M. E., Gerona, R. R., Davis, M. T., Roche, B. M., Colby, D. K., Chenoweth, J. A., … Albertson, T. E. (2017). Fatal Fentanyl: One Pill Can Kill. Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine, 24(1), 106–113. https://doi.org/10.1111/acem.13034 4) Klar, S. A., Brodkin, E., Gibson, E., Padhi, S., Predy, C., Green, C., & Lee, V. (2016). Furanyl-Fentanyl Overdose Events Caused by Smoking Contaminated Crack Cocaine — British Columbia, Canada, July 15–18, 2016. MMWR. Morbidity and Mortality Weekly Report, 65(37), 1015–1016. https://doi.org/10.15585/mmwr.mm6537a6 5) Uddayasankar, U., Lee, C., Oleschuk, C., Eschun, G., & Ariano, R. E. (2018). The Pharmacokinetics and Pharmacodynamics of Carfentanil After Recreational Exposure: A Case Report. Pharmacotherapy. https://doi.org/10.1002/phar.2117 6) George, A. V., Lu, J. J., Pisano, M. V., Metz, J., & Erickson, T. B. (2010). Carfentanil--an ultra potent opioid. The American Journal of Emergency Medicine, 28(4), 530–2. https://doi.org/10.1016/j.ajem.2010.03.003 7) Melichar, J. K., Nutt, D. J., & Malizia, A. L. (2003). Naloxone displacement at opioid receptor sites measured in vivo in the human brain. Eur J Pharmacol, 459(2–3), 217–219. https://doi.org/10.1016/S0014-2999(02)02872-8 8) Cole, J. B., & Nelson, L. S. (2017). Controversies and carfentanil: We have much to learn about the present state of opioid poisoning. American Journal of Emergency Medicine. https://doi.org/10.1016/j.ajem.2017.08.045 9) Connors, N. J., & Nelson, L. S. (2016). The Evolution of Recommended Naloxone Dosing for Opioid Overdose by Medical Specialty. Journal of Medical Toxicology, 12(3), 276–281. https://doi.org/10.1007/s13181-016-0559-3 10) ACMT and AACT Position Statement: Preventing Occupational Fentanyl and Fentanyl Analog Exposure to Emergency Responders. (2016). https://doi.org/10.1007/s13181-017-0628-2 11) Casale, J. F., Mallette, J. R., & Guest, E. M. (2017). Analysis of illicit carfentanil: Emergence of the death dragon. Forensic Chemistry, 3, 74–80. https://doi.org/10.1016/j.forc.2017.02.003 12) Zuckerman, M., Weisberg, S. N., & Boyer, E. W. (2014). Pitfalls of intranasal naloxone. In Prehospital Emergency Care (Vol. 18, pp. 550–554). https://doi.org/10.3109/10903127.2014.896961 13) Chou, R., Korthuis, P. T., McCarty, D., Coffin, P. O., Griffin, J. C., Davis-O’Reilly, C., … Daya, M. (2017). Management of Suspected Opioid Overdose With Naloxone in Out-of-Hospital Settings. Annals of Internal Medicine, 167(12), 867. https://doi.org/10.7326/M17-2224 14) Rzasa Lynn, R., & Galinkin, J. (2018). Naloxone dosage for opioid reversal: current evidence and clinical implications. Therapeutic Advances in Drug Safety, 9(1), 63–88. https://doi.org/10.1177/2042098617744161 15) Kim, S., Wagner, H. N., Villemagne, V. L., Kao, P. F., Dannals, R. F., Ravert, H. T., … Civelek, a C. (1997). Longer occupancy of opioid receptors by nalmefene compared to naloxone as measured in vivo by a dual-detector system. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 38(11), 1726–31. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9374341

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In this episode of The FlightBridgeED Podcast, Eric takes a few minutes to delve into an intriguing aspect of the paralytics we carry out on every flight. As the old quote goes, everything is a poison in the right amount, it is perhaps worth applying this, in a manner of speaking, to the pharmacokinetics of the paralytics we give our patients. Are some of these medications actually doing more harm than we realize? What are the potential problems with the tried-and-true medications we are comfortable with, and that have a long history with providers? Learn how you can bring the cutting edge of medicine to your paralytic toolbox in this episode! Download, rate and review wherever you get your podcasts. The FBE family of podcasts is now available on TuneIn! Get the app now and listen to your favorite podcast and more! Remember that reviews are key to help keep us high on the charts where your friends, and family can find us. We couldn’t make this podcast without you. Thanks for listening!

In this episode of The FlightBridgeED Podcast, Eric takes a few minutes to delve into an intriguing aspect of the paralytics we carry out on every flight. As the old quote goes, everything is a poison in the right amount, it is perhaps worth applying this, in a manner of speaking, to the pharmacokinetics of the paralytics we give our patients. Are some of these medications actually doing more harm than we realize? What are the potential problems with the tried-and-true medications we are comfortable with, and that have a long history with providers? Learn how you can bring the cutting edge of medicine to your paralytic toolbox in this episode! Download, rate and review wherever you get your podcasts. The FBE family of podcasts is now available on TuneIn! Get the app now and listen to your favorite podcast and more! Remember that reviews are key to help keep us high on the charts where your friends, and family can find us. We couldn't make this podcast without you. Thanks for listening!See omnystudio.com/listener for privacy information.

Have you ever wondered what happens to that medicine you so easily flush down the IV line of your patient, or in that capsule your patient swallows? We so often take for granted that an incredibly complex, and amazing chain of processes must take place in order to move the medicine we give to the exact spot where it’s needed. Join Eric Bauer as he peels back the mysterious layers of medication absorption and distribution. As always, this really difficult subject gets broken down into easily understood analogies, and concepts that builds knowledge on top of knowledge. The best part… it’s all free! Download, subscribe, rate, and review wherever you get your podcast from. Did you learn a lot from this podcast? Help us keep this podcast, and more high on the charts so your friends and colleagues can find us easily! Give us a quick review and let the world know how much you like our stuff! Thanks for listening! We couldn’t make this podcast without you.ke a few minutes and write a short review. We couldn’t make this podcast without you!

Have you ever wondered what happens to that medicine you so easily flush down the IV line of your patient, or in that capsule your patient swallows? We so often take for granted that an incredibly complex, and amazing chain of processes must take place in order to move the medicine we give to the exact spot where it's needed. Join Eric Bauer as he peels back the mysterious layers of medication absorption and distribution. As always, this really difficult subject gets broken down into easily understood analogies, and concepts that builds knowledge on top of knowledge. The best part… it's all free! Download, subscribe, rate, and review wherever you get your podcast from. Did you learn a lot from this podcast? Help us keep this podcast, and more high on the charts so your friends and colleagues can find us easily! Give us a quick review and let the world know how much you like our stuff! Thanks for listening! We couldn't make this podcast without you.ke a few minutes and write a short review. We couldn't make this podcast without you!See omnystudio.com/listener for privacy information.

El programa de esta semana es variado. Empezamos por discutir las implicaciones de la bacteriemia por bacilos Gram-negativos resistentes en pacientes con trasplantes de medula ósea. Posteriormente comentamos un articulo sobre el tiempo apropiado de tratamiento en bacteriemia por bacilos Gram-negativos. También comentamos los beneficios del tratamiento combinado vs. el tratamiento simple con oseltamivir en la infección por Influenza. Finalmente hablamos sobre neumonía adquirida en la comunidad, sobre fosfomicina, y nitrofurantoina.   Referencias:   Diana Averbuch y colaboradores. Antimicrobial Resistance in Gram-Negative Rods Causing Bacteremia in Hematopoietic Stem Cell Transplant Recipients: Intercontinental Prospective Study of the Infectious Diseases Working Party of the European Bone Marrow Transplantation Group. Clin Infect Diseases 2017.   Julio A. Ramirez y colaboradores. Adults Hospitalized with Pneumonia in the United States: Incidence, Epidemiology, and Mortality. Clin Infect Dis 2017.   Darunee Chotiprasitsakul  y colaboradores Comparing the Outcomes of Adults With  Enterobacteriaceae Bacteremia Receiving Short-Course  Versus Prolonged-Course Antibiotic therapy in a  Multicenter, Propensity Score–Matched Cohort . Clin Infect Dis 2017   John H Beigel y colaboradores. Oseltamivir, amantadine, and ribavirin combination antiviral therapy versus oseltamivir monotherapy for the treatment of influenza: a multicentre, double-blind, randomised phase 2 trial. Lancet Infect Dis. Dec 2017.   Fiona Fransen y colaboradores. Pharmacodynamics of fosfomycin against ESBL- and/or carbapenemase-producing Enterobacteriaceae. J Antimicrob Chemother. Dec 2017.   Fiona Fransen y colaboradores.  Pharmacodynamics of nitrofurantoin at different pH levels against pathogens involved in urinary tract infections. J Antimicrob Chemother. December 2007     La Frase de la Semana:  La tomamos del poeta Chileno Pablo Neruda. Pablo Neruda Era el seudónimo y, más tarde, el nombre legal del poeta, diplomático y político chileno Ricardo Eliécer Neftalí Reyes Basoalto (12 de julio de 1904 - 23 de septiembre de 1973). Derivó su seudónimo del poeta checo Jan Neruda. Pablo Neruda ganó el Premio Nobel de Literatura en 1971  “Algún día en cualquier parte, en cualquier lugar indefectiblemente te encontrarás a ti mismo, y ésa, sólo ésa, puede ser la más feliz o la más amarga de tus horas”.      

In this edition of the EVJ podcast, Chris Sanchez discusses their paper, entitled 'Factors associated with outcome in 94 hospitalised foals diagnosed with neonatal encephalopathy' and Ben Sykes discusses their paper 'The effects of dose and diet on the pharmacodynamics of omeprazole in the horse'.

A Placebo- and Midazolam-Controlled, Phase I, Single Ascending-Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam: Part I. Safety, Efficacy, and Basic Pharmacokinetics and Part II: Population Pharmacokinetic and Pharmacodynamic Modeling and Simulation

NO.4「トルコのスパイス×薬理学」Turkey spice & pharmacodynamicsWScience515.mp3Click!自動再生No4.mp3 The guestozgur cevik（京都府立医大 薬理学博士）Mr.Ozgur Cevik（Dr.pharmacology of Kyoto Pefectual university of Medicine）KIKA（Opening ending sound）Personality is Yamamoto（...

NO.4「トルコのスパイス×薬理学」Turkey spice & pharmacodynamicsWScience515.mp3Click!自動再生No4.mp3 The guestozgur cevik（京都府立医大　薬理学博士）Mr.Ozgur Cevik（Dr.pharmacology of Kyoto Pefectual university of Medicine）KIKA（Opening ending sound）Personality is Yamamoto（..

NO.4「トルコのスパイス×薬理学」Turkey spice & pharmacodynamicsWScience515.mp3Click!自動再生No4.mp3 The guestozgur cevik（京都府立医大 薬理学博士）Mr.Ozgur Cevik（Dr.pharmacology of Kyoto Pefectual university of Medicine）KIKA（Opening ending sound）Personality is Yamamoto（...