Podcast appearances and mentions of Jim Heath

This episode of the Talking Techniques podcast dives into the realm of cancer immunotherapies, focusing on antigen discovery and T-cell receptor engineering for T-cell therapies. Guiding us through the field is Jim Heath, President of the Institute for Systems Biology in Seattle, where he runs the Heath Lab, investigating fundamental immunology, and infectious and chronic diseases. Jim discusses the computational models and wet lab techniques he uses to characterize T cells, the importance of targeting a balanced immune response with immunotherapies and more in this podcast recorded at AACR 2024 (5th–10th April 2024; San Diego, CA, USA).Contents:Introductions: 00:00-02:00Intro to cancer vaccines and T-cell therapies: 02:00-04:00Antigen detection and validation in T-cell therapies: 04:00-05:20Wet lab and computational techniques for antigen detection: 05:20-09:15The importance of a balanced immune response to cancer immunotherapies: 09:15-10:30Technological developments in antigen detection: 10:30-13:45 Tips for best practice when conducting T-cell receptor design 13:45-15:40What is one thing you would like to see change in the field of antigen detection and T-cell receptor engineering? 15:40-16:30 Designing the path towards a more balanced immune response from immunotherapies 16:30-19:40 Hosted on Acast. See acast.com/privacy for more information.

If there's one person you'd want to talk to about immunology, the immune system and Covid, holes in our knowledge base about the complex immune system, and where the field is headed, it would be Professor Iwasaki. And add to that the topic of Women in Science. Here's our wide-ranging conversation.A snippet of the video, Full length Ground Truths videos are posted here and you can subscribe. Ground Truths is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.Transcript with many external link and links to the audio, recorded 30 April 2024 Eric Topol (00:06):Hello, it's Eric Topol and I'm really thrilled to have my friend Akiko Iwasaki from Yale, and before I start talking with Akiko, I just want to mention there aren't too many silver linings of the pandemic, but one for me was getting to know Professor Iwasaki. She is my go-to immunologist. I've learned so much from her over the last four years and she's amazing. She just, as you may know, she was just recently named one of the most influential people in the world by TIME100. [and also recognized this week in TIME 100 Health]. And besides that, she's been elected to the National Academy of Medicine, National Academy of Sciences. She's the president of the American Association of Immunologists and she's a Howard Hughes principal investigator. So Akiko, it's wonderful to have you to join into an extended discussion of things that we have of mutual interest.Akiko Iwasaki (01:04):Thank you so much, Eric, for having me. I equally appreciate all of what you do, and I follow your blog and tweets and everything. So thank you Eric.Eric Topol (01:14):Well, you are a phenom. I mean just, that's all I can say because I think it was so appropriate that TIME recognize your contributions, not just over the pandemic, but of course throughout your career, a brilliant career in immunology. I thought we'd start out with our topic of great interest on Long Covid. You've done seminal work here and this is an evolving topic obviously. I wonder what your latest thoughts are on the pathogenesis and where things are headed.Long CovidAkiko Iwasaki (01:55):Yeah, so as I have been saying throughout the pandemic, I think that Long Covid is not one disease. It's a collection of multiple diseases and that are sort of ending up in similar sets of symptoms. Obviously, there are over 200 symptoms and not everyone has the same set of symptoms, but what we are going for is trying to understand the disease drivers, so persistent viral infection is one of them. There are overwhelming evidence for that theory now, all the way from autopsy and biopsy studies to looking at peripheral blood RNA signatures as well as circulating spike protein and nucleocapsid proteins that are detected in people with Long Covid. Now whether that persistent virus or remnants of virus is driving the disease itself is unclear still. And that's why trials like the one that we are engaging with Harlan Krumholz on Paxlovid should tell us what percentage of the people are suffering from that type of driver and whether antivirals like Paxlovid might be able to mitigate those. If I may, I'd like to talk about three other hypotheses.Eric Topol (03:15):Yeah, I'd love for you to do that.Akiko Iwasaki (03:18):Okay, great. So the second hypothesis that we've been working on is autoimmune disease. And so, this is clearly happening in a subset of people, again, it's a heterogeneous disease, but we can actually not only look at reactogenicity of antibodies from people with Long Covid where we can transfer IgG from patients with Long Covid into an animal, a healthy animal, and really measure outcomes of a pathogenesis. So that's a functional evidence that antibodies in some people with Long Covid is really actually causing some of the damages that are occurring in vivo. And the third hypothesis is the reactivation of herpes viruses. So many of us adults have multiple latent herpes virus family members that are just dormant and are not really causing any pathologies. But in people with Long Covid, we're seeing elevated reactivation of viruses like Epstein-Barr virus (EBV) or Varicella-zoster virus (VZV) and that may again be just a signature of Long Covid, but it may also be driving some of the symptoms that people are suffering from.(04:32):So that's again, we see the signature over and over, not just our group, but multiple other groups, Michael Peluso's group, Jim Heath, and many others. So that's also an emerging evidence from multiple groups showing that. And finally, we think that inflammation that occurs during the acute phase can sort of chronically change some tissue tone. For instance, in the brain with Michelle Monje's team, we developed a sort of localized mild Covid model of infection and showed that changes in microglia can be seen seven weeks post infection even though the virus is completely gone. So that means that inflammation that's established as a result of this initial infection can have prolonged sequence and sequela within the person and that may also be driving disease. And Eric, the reason we need to understand these diseases separately is because not only for diagnostic purposes, but for therapeutic purposes because to target a persistent virus is very different approach from targeting autoantibodies, for example.Eric Topol (05:49):Well, that's great. There's a lot to unpack there as you laid out four distinct paths that could result in the clinical syndrome and sequelae. I think you know I had the chance to have a really fun conversation with Michelle about their joint work that you've done, and she reminded me how she made a cold call to you to start as a collaboration, which I thought was fantastic. Look what that yielded. But yeah, this is fascinating because as I think you're getting at is that it may not be the same pathogenesis in any given individual so that all these, and even others might be operative. I guess maybe I first delve into the antibody story as you're well aware, we see after people get Covid a higher rate of autoimmune diseases crop up, which is really interesting because it seems to rev up self-directed immune response. And this I think many people haven't really noted yet, although obviously you're well aware of this, it's across all the different autoimmune diseases, connective tissue disease, not just one in particular. And it's, as you say, the idea that you could take the blood from a person suffering from Long Covid and give it to an experimental animal model and be able to recapitulate some of the abnormalities, it's really pretty striking. So the question I guess is if you were to do plasmapheresis and try to basically expunge these autoantibodies, wouldn't you expect people to have some symptomatic benefit pretty rapidly or is it just that the process is already far from the initiating step?Akiko Iwasaki (07:54):That's a great question. Plasmapheresis may be able to transiently improve the person if they're suffering from these autoantibody mediated diseases. People have reported, for example, IVIG treatment has dramatically improved their symptoms, but not in everybody. So it's really critical to understand who's suffering from this particular driver and appropriately treat those people. And there are many other very effective therapies in autoimmune disease field that can be repurposed for treating these patients as well.Eric Topol (08:34):The only clinical trial that has clicked so far, interestingly, came out of Hong Kong with different types of ways to manipulate the gut microbiome, which again, you know better than me is a major modulator of our immune system response. What are your thoughts about taking advantage of that way to somehow modulate this untoward immune response in people with this condition?Akiko Iwasaki (09:07):Yeah, so that is an exciting sort of development, and I don't mean to discount the importance of microbiome at all. It's just the drivers that are mentioning are something that can be directly linked to disease, but certainly dysbiosis and translocation of metabolites and microbiome itself could trigger Long Covid as well. So it's something that we're definitely keeping our eyes on. And as you say, Eric, the immune system is in intimate contact with the gut microbiome and also the gut is intimate contact with the brain. So there's a lot of connections that we really need to be paying attention to. So yeah, absolutely. This is a very exciting development.Eric Topol (09:57):And it is intriguing of course, the reactivation of viruses. I mean, we've learned in recent years how important EBV is in multiple sclerosis (MS). The question I have for you on that pathway, is this just an epiphenomena or do you actually think that could be a driving force in some people?Akiko Iwasaki (10:19):Yeah, so that's really hard to untangle in people. I mean, David Putrino and my team we're planning a clinical trial using Truvada. Truvada obviously is an HIV drug, but it has reported antiviral activity to Epstein-Barr virus (EBV) and others. So potentially we can try to interrogate that in people, but we're also developing mouse models that can sort of recapitulate EBV like viral reactivation and to see whether there's any sort of causal link between the reactivation and disease process.Eric Topol (10:57):Right now, recently there's been a bunch of anecdotes of people who get the glucagon-like peptide one (GLP-1) drugs which have a potent anti-inflammatory, both systemic and in the brain. I'd love to test these drugs, but of course these companies that make them or have other interests outside of Long Covid, do you think there's potential for a drug like that?Akiko Iwasaki (11:23):Yeah, so those drugs seem to have a lot of miraculous effects on every disease. So obviously it has to be used carefully because many people with Long Covid have issues with liver functions and other existing conditions that may or may not be conducive to taking those types of GLP-1 agonists. But in subset of people, maybe this can be tried, especially due to the anti-inflammatory properties, it may benefit again, a subset of people. I don't expect a single drug to cure everyone. That would be pretty amazing, but unlikely.Eric Topol (12:09):Absolutely. And it's unfortunate we are not further along in this whole story of clinical trials, testing treatments and applauding your efforts with my friend Harlan there to get into the testing which we had hoped RECOVER was going to do with their more than billion dollars or allocation, which didn't get us too far in that. Now before we leave Long Covid, which we could speak about for hours, I mean it's so darn important because so many people are really out there disabled or suffering on a daily basis or periodically they get better and then get worse again. There's been this whole idea that, oh, it's going away and that reinfections don't pose a threat. Maybe you could straighten that story out because I think there seems to be some miscues about the risk of Long Covid even as we go along with the continued circulating virus.Akiko Iwasaki (13:11):Right, so when you look at the epidemiological evidence of Long Covid, clearly in the beginning when we had no vaccines, no antivirals, no real good measure against Covid, the incident of developing Long Covid per infection was higher than a current date where we do have vaccines and Omicron may have changed its property significantly. So if you compare, let's say the Delta period versus Omicron period, there seems to be a reduced risk per infection of Long Covid. However, Omicron is super infectious. It's infected millions of people, and if you look at the total number of people suffering from Long Covid, we're not seeing a huge decline there at all because of the transmissibility of Omicron. So I think it's too early for us to say, okay, the rates are declining, we don't need to worry about it. Not at all, I think we still have to be vigilant.(14:14):We need to be up to date on vaccines and boosters because those seem to reduce the risk for Long Covid and whether Paxlovid can reduce the rate of Long Covid at the acute phase for the high risk individual, it seems to be yes, but for people who are not at high risk may or may not be very effective. So again, we just need to be very cautious. It's difficult obviously, to be completely avoiding virus at this time point, but I think masking and anything you can do, vaccination boosters is going to be helpful. And a reinfection does carry risk for developing Long Covid. So that prior infection is not going to prevent Long Covid altogether, even though the risk may be slightly reduced in the first infection. So when you think about these risks, again we need to be cognizant that reinfection and some people have multiple infections and then eventually get Long Covid, so we're just not safe from Long Covid yet.Nasal Vaccines and Mucosal ImmunityEric Topol (15:24):Right. No, I think that's the problem is that people have not acknowledged that there's an ongoing risk and that we should continue to keep our guard up. I want to applaud you and your colleagues. You recently put out [Yale School of Public Health] this multi-panel about Covid, which we'll post with this podcast that gave a lot of the facts straight and simple diagrams, and I think this is what you need is this is kind of like all your threads on Twitter. . They're always such great educational ways to get across important information. So now let's go onto a second topic of great mutual interest where you've also been a leader and that's in the mucosal nasal vaccine story. I had the privilege of writing with you a nice article in Science Immunology back in 2022 about Operation Nasal Vaccine, and unfortunately we don't have a nasal vaccine. We need a nasal vaccine against Covid. Where do we stand with this now?Akiko Iwasaki (16:31):Yeah, so you're right. I mean nasal vaccines, I don't really know what the barrier is because I think the preclinical models all support the effectiveness against transmission and infection and obviously disease. And there is a White House initiative to support rapid development of next generation vaccine, which includes mucosal vaccine, so perhaps that's sort of pushing some of these vaccine candidates forward. You're probably more familiar than me about those kinds of events that are happening. But yeah, it's unfortunate that we don't have an approved mucosal booster vaccine yet, and our research has shown that as simple as a spray of recombinant spike protein without any adjuvants are able to restimulate immune response and then establish mucosal immunity in the nasal cavity, which goes a long way in preventing infection as well as transmission. So yeah, I mean I'm equally frustrated that things like that don't exist yet.The Neomycin and Neosporin SurpriseEric Topol (17:52):Well, I mean the work that you and many other groups around the world have published on this is so compelling and this is the main thing that we don't have now, which is a way to prevent infection. And I think most of us would be very happy to have a spray that every three or four months and gave us much higher levels of protection than we're ever going to get from shots. And your whole concept of prime and spike, I mean this is something that we could have had years ago if there was a priority, and unfortunately there never has been. Now, the other day you came with a surprise in a paper on Neomycin as an alternate or Neosporin ointment. Can you tell us about that? Because that one wasn't expected. This was to use an antibiotic in a way to reduce Covid and other respiratory virus.Akiko Iwasaki (18:50):Right. So yeah, that's a little known fact. I mean, of course widespread use of antibiotics has caused some significant issues with resistance and so on. However, when you look at the literature of different types of antibiotics, we have reported in 2018 that certain types of antibiotics known as aminoglycoside, which includes Neosporin or neomycin, has this sort of unintended antiviral property by triggering Toll-like receptor 3 in specialized cell types known as conventional dendritic cell type 1. And we published that for a genital herpes model that we were working on at the time. But because it's acting on the host, the Toll-like receptor 3 on the host cell to induce interferon and interferon stimulated genes to prevent the replication of the virus, we knew that it could be pan-viral. It doesn't really matter what the virus is. So we basically leverage that discovery that was made by a postdoc Smita Gopinath when she was in the lab to see if we can use that in the nasal cavity.(20:07):And that's what Tianyang Mao, a former graduate student did, in fact. And yeah, little spray of neomycin in the nose of the mice reduce this infection as well as disease and can even be used to treat shortly after the infection disease progress and using hamster models we also showed that hamsters that are pretreated with neomycin when they were caged with infected hamsters, the transmission rate was much reduced. And we also did with Dr. Charles Dela Cruz, a small clinical trial, randomized though into placebo and Neosporin arms of healthy volunteers. We asked them to put in a pea size amount of Neosporin on a cotton swab into the nose, and they were doing that twice a day for seven days. We measured the RNA from the nose of these people and indeed see that more than half the participants in the Neosporin group had elevated interferon stimulated genes, whereas the control group, which were given Vaseline had no response. So this sort of shows the promise of using something as generic and cheap as Neosporin to trigger antiviral state in the nose. Now it does require a much larger trial making sure that the safety profiles there and effectiveness against viral infection, but it's just a beginning of a story that could develop into something useful.New Frontiers in Immunology and Tx CellsEric Topol (21:51):Yeah, I thought it was fascinating, and it does bring up, which I think has also been underdeveloped, is our approaches for interferon a frontline defense where augmenting that, just getting that exploiting the nasal mucosa, the entry site, whether it be through that means or of course through even more potent a nasal vaccine, it's like a missing, it's a hole in our whole defense of against this virus that's led to millions of people not just dying, but of course also sick and also with Long Covid around the world. So I hope that we'll see some progress, but I thought that was a really fascinating hint of something to come that could be very helpful in the meantime while we're waiting for specific nasal vaccines. Now added to all these things recently, like last week you published a paper in Cell with your husband who's in the same department, I think at Yale. Is that right? Can you tell us about that and this paper about the whole new perspectives in immunology?Akiko Iwasaki (23:05):Yeah, so my husband Ruslan Medzhitov is a very famous immunologist who's in the same department, and we've written four or five review and opinion pieces together over the years. This new one is in Cell and it's really exploring new perspectives in immunology. We were asked by the editors to celebrate the 50th anniversary of the Cell journal with a perspective on the immune system. And the immune response is just a beautiful system that is triggered in response to specific pathogens and can really provide long-term or even sometimes lifelong immunity and resistance against pathogens and it really saves our lives. Much has been learned throughout the last 20, 30 years about the innate and adaptive immune system and how they're linked. In this new perspective, we are trying to raise some issues that the current paradigm cannot explain properly, some of the mysteries that are still remaining in the immune system.(24:22):And we try to come up with new concepts about even the role of the immune system in general. For instance, is the immune system only good for fighting pathogens or can it be repurposed for conducting normal physiology in the host? And we came up with a new subset of T-cells known as, or we call it Tx cells, which basically is an interoceptive type of T-cells that monitor homeostasis in different tissues and are helping with the normal process of biology as opposed to fighting viruses or bacteria or fungi. But these cells, when they are not appropriately regulated, they are also the source of autoimmune diseases because they are by design reactive against auto antigens. And so, this is a whole new framework to think about, a different arm of the immune function, which is really looking inside of our body and not really fighting against pathogens, but we believe these cells exist, and we know that the counterpart of Tx cells, which is the T regulatory cells, are indeed well known for its physiological functions. So we're hoping that this new perspective will trigger a new set of approaches in the field to try to understand this interceptive property of T-cells.Eric Topol (25:59):Yeah, well, I thought it was fascinating, of course, and I wanted to get into that more because I think what we're learning is this immune system not only obviously is for cancer whole. We're only starting to get warmed up with immunotherapy where checkpoint inhibitors were just the beginning and now obviously with vaccines and all these different ways that we can take the CAR-T cells, engineered T-cells, take the immune system to fight cancer and potentially to even use it as a way to prevent cancer. If you have these, whether it's Tx or Tregs or whatever T-cells can do this. But even bigger than that is the idea that it's tied in with the aging process. So as you know, again, much more than I do, our senescent immune cells are not good for us. And the whole idea is that we could build immune resilience if we could somehow figure out these mysteries that you're getting at, whereby we get vulnerable just as we were with Covid. And as we get older, we get vulnerable to not just infections, but everything going wrong, whether it's the walls of our arteries or whether it's the cancer or the immunity that's going on in our brain for Alzheimer's and neurodegenerative diseases. How can we fix the immune system so that we age more healthilyThe Immune System and Healthy Aging Akiko Iwasaki (27:37):Oh yeah. A lot of billionaires are also interested in that question and are pouring money into this question. It's interesting, but when you think about the sort of evolutionary perspective, we humans are only living so long. In the very recent decades, our life expectancy used to be much shorter and all we had to survive was to reproduce and generate the next progeny. But nowadays, because of this amazing wealth and health interventions and food and everything else, we're just living so much longer than even our grandparents. The immune system didn't evolve to deal with such one to begin with. So we were doing fine living up to 30 years of age or whatever. But now that we're living up to a hundred years, the immune system isn't really designed to keep up with this kind of stressors. But I think you're getting at a very important kind of more engineering questions of how do we manipulate the immune system or rejuvenate it so that we can remain healthy into the later decades? And it is well known that the immune system itself ages and that our ability to produce new lymphocytes, for example, decline over time and thymus that is important for T-cell development shrinks over time. And so anatomically it's impossible to help stop that process. However, is there a way of, for example, transferring some factors or engineering the immune cells to remain healthy and even like hematopoiesis itself can be manipulated to perhaps rejuvenate the whole immune system in their recent papers showing that. So this is a new frontier.Eric Topol (29:50):Do you think that some point in the future, we'll ex vivo inject Yamanaka factors into these cell lines and instead of this idea that you know get young plasma to old folks, and I mean since we don't know what's in there and it doesn't specifically have an effect on immune cells, who knows how it's working, but do you foresee that that might be a potential avenue going forward or even an in vivo delivery of this?Akiko Iwasaki (30:22):Yeah, it's not impossible, right? There are really rapidly evolving technologies and gene therapies that are becoming online. So it's not impossible to think about engineering in situ as you're suggesting, but we also have to be certain that we are living longer, but also healthy. So we do have to not only just deal with the aging immune system, but preventing neurodegenerative diseases and so on. And the immune system may have a role to play there as well. So there's a lot of, I mean, I can't think of a non-genetically mediated disease that doesn't involve the immune system.Eric Topol (31:03):Sure. No, I mean, it's just, when I think about this, people keep talking about the digital era of digital biology, but I actually think of it more as digital immunobiology, which is driving this because it's center stage and in more and more over time. And the idea that I'm concerned about is that we could rejuvenate the relevant immune cells or the whole immune response, but then it's such a delicate balance that we could actually wind up with untoward, whether it's autoimmune or overly stimulated immune system. It's not such a simple matter, as I'm sure you would agree. Now, this gets me to a broader thing which you've done, which is a profound contribution in life science and medicine, which is being an advocate for women in science. And I wonder if you could speak to that because you have been such a phenomenal force propelling the importance of women in science and not just doing that passively, but also standing up for women, which is being an activist is how you get things to change. So can you tell us about your thoughts there?An Activist for Women in ScienceAkiko Iwasaki (32:22):Yeah, so I grew up in Japan, and part of the reason I left Japan at the age of 16 was that I felt very stifled because of the societal norm and expectation of what a woman should be. And I felt like I didn't have the opportunity to develop my skills as a scientist remaining in Japan. And maybe things have changed over the years, but at the time when I was growing up, that's how I felt. And so, I was very cognizant of biases in society. And so, in the US and in Canada where I also trained, there's a lot less barrier to success, and we are able to do pretty much anything we want, which is wonderful, and that's why I think I'm here. But at the same time, the inequity still exists, even in pay gaps and things like that that are easy to fix but are still kind of insidious and it's there.(33:32):And Yale School of Medicine has done a great job partly because of the efforts of women who spoke up and who actually started to collect evidence for pay gap. And now there's very little pay gap because there's active sort of involvement of the dean and everyone else to ensure equity in the medical school. But it's just a small segment of the society. We really need to expand this to other schools and making sure that women are getting paid equally as men in the same ranks. And also, I see still some sexual harassment or more just toxic environment for people in general in academia. Some PIs get away with a lot of behavior that's not conducive to a healthy environment, so I have written about that as well and how we can have antidotes for such toxic environments. And it really does require the whole village to act on it. It's not just one person speaking up. And there should be measures placed to make sure that those people who does have this tendency of abusive behavior that they can get training and just being aware of these situations and corrective behavior. So I think there's still a lot of work left in academia, but things have obviously improved dramatically over the last few decades, and we are in a very, very good place, but we just have to keep working to achieve true equity.Why Don't We Have Immunome Check-Ups?Eric Topol (35:25):Well applauding your efforts for that, and I'm still in touch with that. We got a ways to go, and I hope that we'll see steady and even more accelerated and improvement to get to parity, which is what it should be. And I really think you've been a model for doing this. It isn't like you aren't busy with everything else, so to fit that in is wonderful. In closing up, one of the things that I wonder about is our ability to assess back to the immune system for a moment isn't what it should be. That is we do a CBC and we have how many lymphocytes, how many this, why don't we have an immunome, why doesn't everybody serially have an immune system checkup? Because that would tell us if we're starting to go haywire and then maybe hunt for reactivated viruses or what's going on. Do you foresee that we could ever get to a practical immunome as we go forward? Because it seems like it's a big missing link right now.Akiko Iwasaki (36:33):Yeah, I think that's a great idea. I mean, I'll be the first one to sign up for the immunome.Eric Topol (36:40):But I'm depending on you to make it happen.Akiko Iwasaki (36:44):Well, interestingly, Eric, there are lots of amazing technologies that are developed even during the pandemic, which is monitoring everything from antibody reactivity to reactivated viruses to the cytokines to every cell marker you can imagine. So the technologies out there, it's just I think a matter of having the right set of panels that are relatively affordable because some of these things are thousands of dollars per sample to analyze, and then of course clinical validation, something that's CLIA approved, and then we can start to, I guess the insurance company needs to also cover this, right? So we need to demonstrate the benefit to health in the long run to be able to afford this kind of immunome analysis. But I think that very wealthy people can already get this done.Eric Topol (37:43):Yeah, well, we want to make it so it's a health equity story, not of course, only for the crazy ones that are out there that are taking 112 supplements a day and whatnot. But it's intriguing because I think we might be able to get ahead of things if we had such an easy means. And as you said during the pandemic, for example, my friends here in La Jolla at La Jolla Immunology did all kinds of T-cell studies that were really insightful and of course done with you and others around the country and elsewhere to give us insights that you didn't get just from neutralizing antibodies. But it isn't something that you can get done easily. Now, I think this immunome hopefully will get us to another level in the future. One of the most striking things I've seen in our space clinically before wrapping up is to take the CD19 CAR T therapies to deplete the B cells of people with lupus, systemic sclerosis and other conditions, and completely stop their autoimmune condition. And when the B cells come back, they're not fighting themselves. They're not self-directed anymore. Would you have predicted this? This seems really striking and it may be a clue to the kind of mastering approaches to autoimmune diseases in the future.Akiko Iwasaki (39:19):Yeah, absolutely. So for multiple sclerosis, for example, where B cells weren't thought to be a key player by doing anti-CD20 depletion, there's this remarkable clinical effects. So I think we can only find the answer experimentally in people when they do these clinical trials and show this remarkable effects. That's when we say, aha, we don't really understand immunology. You know what I mean? That's when we have to be humble about what we think we understand. We really don't know until we try it. So that's a really good lesson learned. And these may be also applicable to people with autoimmune phenotype in Long Covid, right? We may be able to benefit from similar kinds of depletion therapy. So I think we have a lot to learn still.Eric Topol (40:14):Yeah, that's why, again, going back to the paper you just had in Cell about the mysteries and about some new ideas and challenging the dogma is so important. I still consider the immune system most complex one in the body by far, and I'm depending on you Akiko to unravel it, not to put any weight on your shoulders. Anyway, this has been so much fun. You are such a gem and always learning from you, and I can't thank you enough for all the work. And the fact is that you've got decades ahead of you to keep building on this. You've already done enough for many people, many scientists in your career, and I know you'll keep going. So we're all going to be following you with great interest in learning from you on a frequent basis. And I hope we'll build on some of the things we've talked about like a Long Covid treatment, treatments that are effective nasal vaccines, maybe even some dab of Neosporin, and keep on the momentum we've had with the understanding of the immune system, and finally, someday achieving the true parity of gender and science. And so, thank you for all that you do.Akiko Iwasaki (41:35):Thank you so much, Eric.************************CreditsHeadshot photo credits by Robert Lisak, Yale School of MedicineMy producer for Ground Truths is Jessica Nguyen, Scripps Research and our technical support for audio/video is by SInjun Balabanoff at Scripps Research.I hope you found the spot informative. Please share itThe Ground Truths newsletters and podcasts are all free, open-access, without ads.Voluntary paid subscriptions all go to support Scripps Research. Many thanks for that—they greatly helped fund our summer internship programs for 2023 and 2024.Note: you can select preferences to receive emails about newsletters, podcasts, or all I don't want to bother you with an email for content that you're not interested in.Comments are welcome from all subscribers. Get full access to Ground Truths at erictopol.substack.com/subscribe

Kyle Eldridge, has been burning his way into the Country & Western scene and has quickly become in demand both domestically and abroad. From Louisville, Kentucky Kyle has known as one of the most prominent guitar players in the traditional scene for his Joe Maphis/ Merle Travis and Western Jazz styling. Kyle got his start playing in the south where he met Upright Bassist Dakota Collins who brought him to Nashville, Tennessee. They began playing Honky Tonks on the famous Broadway strip and soon after, he recorded his debut EP in Los Angeles, California at Deke Dickerson's studio. Kyle has played alongside artists from Jim Heath of Reverend Horton Heat, to Shaun Young of High Noon, and Dale Watson and his Lone Stars among others. 

Taking us to the cutting edge of the new frontier of medicine, a visionary biotechnologist and a pathbreaking researcher show how we can optimize our health in ways that were previously unimaginable. We are on the cusp of a major transformation in healthcare—yet few people know it. At top hospitals and a few innovative health-tech startups, scientists are working closely with patients to dramatically extend their “healthspan”—the number of healthy years before disease sets in. In The Age of Scientific Wellness, two visionary leaders of this revolution in health take us on a thrilling journey to this new frontier of medicine. Today, most doctors wait for clinical symptoms to appear before they act, and the ten most commonly prescribed medications confer little or no benefit to most people taking them. Leroy Hood and Nathan Price argue that we must move beyond this reactive, hit-or-miss approach to usher in real precision health—a form of highly personalized care they call “scientific wellness.” Using information gleaned from our blood and genes and tapping into the data revolution made possible by AI, doctors can catch the onset of disease years before symptoms arise, revolutionizing prevention. Current applications have shown startling results: diabetes reversed, cancers eliminated, Alzheimer's avoided, and autoimmune conditions kept at bay. This is not a future fantasy: it is already happening, but only for a few patients and at a high cost. It's time to make this gold standard of care more widely available. Inspiring in its possibilities, and radical in its conclusions, The Age of Scientific Wellness shares actionable insights to help you chart a course to a longer, healthier, and more fulfilling life. Dr. Leroy Hood is a world-renowned scientist and recipient of the National Medal of Science in 2011. Dr. Hood co-founded the Institute for Systems Biology (ISB) in 2000, served as its first President from 2000-2017 and is a Professor and Chief Strategy Officer. In 2022, Dr. Hood started Phenome Health, a non-profit dedicated to delivering value through health innovation. Dr. Nathan Price is CEO of Onegevity, a division of Thorne HealthTech. He is also an (on leave) Professor at the Institute for Systems Biology, where he and Lee Hood co-direct the Hood-Price Lab for Systems Biomedicine. Additionally, Dr. Price is an affiliate faculty at the University of Washington in the Departments of Bioengineering, Computer Science & Engineering, and Molecular & Cellular Biology. In 2019, he was selected by the National Academy of Medicine as one of their 10 Emerging Leaders in Health and Medicine. Dr. Jim Heath is President and Professor at Institute for Systems Biology in Seattle. Heath also has the position of Professor of Molecular and Medical Pharmacology at UCLA. Formerly, he directed the National Cancer Institute-funded NSB Cancer Center, was the Elizabeth W. Gilloon Professor of Chemistry at Caltech, and served as co-director of the Parker Institute for Cancer Immunotherapy at UCLA until 2017. Presented by Town Hall Seattle and the Institute of Systems Biology. The Age of Scientific Wellness: Why the Future of Medicine Is Personalized, Predictive, Data-Rich, and in Your Hands Third Place Books

While many would think art and science are two vastly different disciplines, one common driver often motivates them both – curiosity. Ginny Ruffner – who currently has a retrospective exhibition open at the Bainbridge Island Museum of Art on the topic of “What if?” – has worked at the intersection of art and science for decades. Her curiosity around biological concepts has propelled her to invent answers to “what if?” questions about the nature of the world around us. The experimental works she creates often involve the use of technology and mixed media to create new and imaginative experiences. Her creations are fueled by collaboration and camaraderie with scientists such as ISB President Dr. Jim Heath. Join us in person at Town Hall Seattle for a conversation with internationally renowned artist Ginny Ruffner and ISB President Dr. Jim Heath. Together, they will explore the opportunities and striking similarities that lie at the intersection of art and science. Ginny Ruffner is a pioneering American glass artist based in Seattle. She is known for her use of the lampworking technique and for her use of borosilicate glass in her painted glass sculptures. Many of her ideas begin with drawings. Her works also include pop-up books, large-scale public art, and augmented reality. Ruffner was named a Master of the Medium by the James Renwick Alliance in 2007. She received The Glass Art Society's Lifetime Award in 2019. Ruffner currently has a retrospective exhibition open at the Bainbridge Island Museum of Art on the topic of “What if?” Dr. Jim Heath is President and Professor at Institute for Systems Biology in Seattle. Heath also has the position of Professor of Molecular and Medical Pharmacology at UCLA. Formerly, he directed the National Cancer Institute-funded NSB Cancer Center, was the Elizabeth W. Gilloon Professor of Chemistry at Caltech, and served as co-director of the Parker Institute for Cancer Immunotherapy at UCLA until 2017. Presented by Town Hall Seattle and the Institute of Systems Biology. Our community partner for this event is the Bainbridge Island Museum of Art.

Chris Sullivan's Chokepoint -- I-5 closures in Everett // Dr. Jim Heath, ISB, on predicting and treating long COVID // Dose of Kindness -- a stuffed animal Santa for seniors // Gee Scott on the Holiday Magic auction/ airport etiquette // Holiday Magic -- Hanna Scott on Treehouse legislative prioritiesSee omnystudio.com/listener for privacy information.

A silent epidemic of chronic illnesses afflicts tens of millions of Americans: These are diseases that are poorly understood, frequently marginalized, and can go undiagnosed and unrecognized altogether. In her latest book – The Invisible Kingdom: Reimagining Chronic Illness – renowned writer Meghan O'Rourke delivers a revelatory investigation into this elusive category of “invisible” illness that encompasses autoimmune diseases, post-treatment Lyme disease syndrome, and now long COVID, synthesizing the personal and the universal to help all of us through this new frontier. O'Rourke is joined by ISB President Dr. Jim Heath, who has deeply studied long COVID and its similarities to other chronic illnesses, to discuss chronic diseases, how they've traditionally been understood and treated, and what the future holds. Meghan O'Rourke is the author of the New York Times bestseller The Invisible Kingdom: Reimagining Chronic Illness and The Long Goodbye, as well as the poetry collections Sun In Days, Once, and Halflife. Her writing has appeared in The Atlantic Monthly, The New Yorker, and The New York Times, and more. The recipient of a Guggenheim Fellowship, a Radcliffe Fellowship, and a Whiting Nonfiction Award, she resides in New Haven where she teaches at Yale University and is the editor of The Yale Review. Dr. Jim Heath is President and Professor at Institute for Systems Biology in Seattle. Heath also has the position of Professor of Molecular and Medical Pharmacology at UCLA. Formerly, he directed the National Cancer Institute-funded NSB Cancer Center, was the Elizabeth W. Gilloon Professor of Chemistry at Caltech, and served as co-director of the Parker Institute for Cancer Immunotherapy at UCLA until 2017. Presented by Town Hall Seattle and the Institute of Systems Biology. The Invisible Kingdom: Reimagining Chronic Illness (Hardcover) Third Place Books

Q&A in The Stoic Salon with Massimo Pigliucci and Gregory Lopez, authors of "Live Like a Stoic" (UK edition) and "A Handbook for New Stoics" (USA edition).     Join us here: https://www.tickettailor.com/events/thestoicsalon/639919   Timestamps: 00:00 Welcome to The Stoic Salon Podcast 00:11 Musical intro 00:25 Kathryn's rather rambly introduction (which you should probably skip!) 07:03 Welcoming Massimo and Greg to The Stoic Salon 07:55 Question No. 1 on Week 22, Speak little but well. 12:55 Question No. 2 from Scott Bennett on Week 14 Evaluate Your Goals and it is about aligning personal philosophy and professional goals. 20:07 Question No. 3 from Victor De Los Santos on Week 18, “Keep your peace of mind in mind” and it's about how to evaluate the things that are worth the effort to change. 32:15 Question No. 4 from Wayne Basinger on Week 21 - Choose Your Company Well and it's about strategies for finding good company. 41:20 Question No. 5 from Michelle Thomas on Week 25 Dealing virtously with frustrating people and it's about how to avoid assenting to the wrong impressions. 51:40 Question No. 6 from Jim Heath on Marcus Aurelius and the True Self. 58:20 Question No. 7 from Kathryn on Week 35 - Question every action and it's about regret and taking a Stoic approach when it seems so countercultural #Stoicism #StoicSalon #KathrynKoromilas

The 72nd annual Headliner's Night, hosted by the Peninsula Sports Club, took place on June 27 at the Omni Hotel in Newport News, Virginia. William & Mary football play-by-play commentator Jay Colley served as the Master of Ceremonies for the annual event, which featured Mat Talk Online's Jason Bryant as the event's Keynote Speaker. In 2021, Bryant received the Bob Moskowitz Media Award from the Peninsula Sports Club just hours after he left the Olympic Games in Tokyo. This year, he had a chance to speak about his experiences around the mat, but how much his life was shaped by watching and covering sports on the Peninsula before breaking out into the world of international wrestling. The entire night is captured on this episode of the Short Time Wrestling Podcast. The keynote stars around 11 minutes in with a lot of Virginia-based stuff before and after if that's your kinda thing. Photo provided by Jim Heath. Links to Follow
Join the Discord: https://www.mattalkonline.com/discord Daily Wrestling Newsletter: https://www.mattalkonline.com/newsContribute: https://www.mattalkonline.com/contributePatreon: https://www.patreon.com/mattalkonlineRokfin: https://www.rokfin.com/creator/mattalkonlineThe Short Time Time Wrestling Podcast is proudly supported by Compound Sportswear: https://www.mattalkonline.com/compoundQuick Subscribe: https://www.Podfollow.com/shorttime
Short Time Wrestling Podcast: Episode 707 – June 30, 2022

The 72nd annual Headliner's Night, hosted by the Peninsula Sports Club, took place on June 27 at the Omni Hotel in Newport News, Virginia. William & Mary football play-by-play commentator Jay Colley served as the Master of Ceremonies for the annual event, which featured Mat Talk Online's Jason Bryant as the event's Keynote Speaker.  In 2021, Bryant received the Bob Moskowitz Media Award from the Peninsula Sports Club just hours after he left the Olympic Games in Tokyo. This year, he had a chance to speak about his experiences around the mat, but how much his life was shaped by watching and covering sports on the Peninsula before breaking out into the world of international wrestling. The entire night is captured on this episode of the Short Time Wrestling Podcast. The keynote stars around 11 minutes in with a lot of Virginia-based stuff before and after if that's your kinda thing.  Photo provided by Jim Heath.  Links to FollowJoin the Discord: https://www.mattalkonline.com/discord  Daily Wrestling Newsletter: https://www.mattalkonline.com/news Contribute: https://www.mattalkonline.com/contribute Patreon: https://www.patreon.com/mattalkonline Rokfin: https://www.rokfin.com/creator/mattalkonline The Short Time Time Wrestling Podcast is proudly supported by Compound Sportswear: https://www.mattalkonline.com/compound Quick Subscribe: https://www.Podfollow.com/shorttime Short Time Wrestling Podcast: Episode 707 – June 30, 2022

In the hundreds of walks that you've taken this past year, to get out of the house and flee from screens, have you noticed things around you that you have questions about but don't have the tools to answer? Maybe you've wondered how exactly that mushroom got there or thought again about the mysterious migratory patterns of birds. Join New York Times bestselling author and world-renowned scientist and autism spokesperson Dr. Temple Grandin to hear about her newest book The Outdoor Scientist: The Wonder of Observing the Natural World. Indulging our curiosity about the natural systems at work around us, Dr. Grandin introduced us to scientists from fields of study such as geology, astrophysics, and oceanography to explain how they research their own curiosities and what tools we can use to discover more ourselves. Bring the whole family and learn many ways you can conduct scientific research together! Following her presentation, Dr. Grandin will join ISB President Dr. Jim Heath for a conversation and will answer questions from the audience. Dr. Temple Grandin is one of the world's most accomplished and well-known adults with autism. She has a PhD in animal science from the University of Illinois and is a professor at Colorado State University. She is the author of twelve books on autism and animal behavior, including the national bestsellers Calling All Minds, Thinking in Pictures, and Animals in Translation. Dr.Grandin was inducted in the National Women's Hall of Fame and the American Academy of Arts and Sciences, and in 2018 she was made a fellow of the American Association for the Advancement of Science. She lectures to parents and teachers throughout the U.S. on her experiences with autism, and her work has been covered in the New York Times, People, National Public Radio, and 20/20. The 2010 HBO movie based on her life, starring Claire Danes, received seven Emmy Awards. Dr. Jim Heath is a chemist and the president and professor of Institute of Systems Biology. He also has the position of Professor of Molecular and Medical Pharmacology at UCLA, and he has directed the National Cancer Institute-funded NSB Cancer Center since 2005. Buy the Book: https://www.elliottbaybook.com/book/9780593115558  Watch the live event Presented by Town Hall Seattle and KUOW. 

Apostle Jim Heath shares a powerful message on the integrity of God's Word and How to Live by Faith and Victory.

Institute for Systems Biology (ISB) is a collaborative cross-disciplinary nonprofit biomedical research organization based in Seattle. ISB and Town Hall proudly present ISB President Jim Heath in conversation with Rod Hochman, President and CEO of Providence. Join them for a discussion exploring what the future of healthcare might look like in a post-pandemic world. Dr. Jim Heath is a chemist and the president and professor of Institute of Systems Biology. He also has the position of Professor of Molecular and Medical Pharmacology at UCLA, and he has directed the National Cancer Institute-funded NSB Cancer Center since 2005. Dr. Rod Hochman is the president and CEO of Providence St. Joseph Health, a Catholic not-for-profit health system. He is the chair elect designate for the American Hospital Association (AHA), chair of AHA’s Regional Policy Board 9, and past chair of the board of trustees for the Catholic Health Association. Presented by Town Hall Seattle & Institute for Systems Biology. To become a Town Hall Seattle member or make a donation click here. 

Apostle Jim Heath shares a powerful message on the integrity of God's Word and How to Live by Faith and Victory.

Jason Loughlin talks about his guitar lessons available on TrueFire, perform, and answer questions. To learn more and watch the video from this live session, please visit truefire.com/live.About Jason:Jason Loughlin's creative guitar playing has supported artists such as Emmylou Harris, Steve Earle, Mary Chapin Carpenter, Amos Lee, Sam Outlaw, Brandi Carlile, Rachael Yamagata, The Secret Sisters, Valerie June, Keb Mo, Jennifer Nettles, Brent Cobb, Shannon McNally, Jack Ingram, Marshall Crenshaw, Dale Watson, Jim Heath, Nellie McKay, Lesley Gore, The Sweetback Sisters, James Burton and Mike Viola. In 2011, Jason released his debut album Peach Crate which was met with critical acclaim."We hear an instrumentalist of great range, taste and joy."-Downbeat MagazineUncannily well-constructed launching pads for great picking. A great guitar album that could easily sit alongside those of his inspirations.-Vintage Guitar MagazineCurrently, Jason lives in Brooklyn, NY where he performs with his bands The String Gliders and Aquarium Solarium, teaches and produces records.

Jim Heath, W6LG, has been a ham for over 56 years.  Jim is an Elmer’s Elmer with an amazing You-Tube channel, with over 30,000 subscribers. Jim not only reviews the basics of amateur radio, and he makes that content up close and personal, reflecting on his years of experience as an amateur radio operator.

Jason Loughlin discusses his surf guitar lessons available on TrueFire, performs, and answers questions. To learn more and watch the video from this live session, please visit truefire.com/live.About Jason: Jason Loughlin's creative guitar playing has supported artists such as Emmylou Harris, Steve Earle, Mary Chapin Carpenter, Amos Lee, Sam Outlaw, Brandi Carlile, Rachael Yamagata, The Secret Sisters, Valerie June, Keb Mo, Jennifer Nettles, Brent Cobb, Shannon McNally, Jack Ingram, Marshall Crenshaw, Dale Watson, Jim Heath, Nellie McKay, Lesley Gore, The Sweetback Sisters, James Burton and Mike Viola. In 2011, Jason released his debut album Peach Crate which was met with critical acclaim."We hear an instrumentalist of great range, taste and joy."-Downbeat MagazineUncannily well-constructed launching pads for great picking. A great guitar album that could easily sit alongside those of his inspirations.-Vintage Guitar MagazineCurrently, Jason lives in Brooklyn, NY where he performs with his bands The String Gliders and Aquarium Solarium, teaches and produces records.

I am stoked to bring you this bonus episode with none other than The Reverend Horton Heat, Jim Heath! We get into music and politics and everything in between. Considered by many to be the Godfather of modern rockabilly and psychobilly, Jim has been playing music for decades. Now, due to this COVID-19 craziness, he has been forced to cancel all of his gigs. Initially, he was willing to keep playing for his crew and bandmates, but when he announced that, he received a lot of personal attacks from the online mob. He's here to discuss how that all went down and a lot more. Find the Reverend Horton Heat online here: Join the Libertarian Party through my link! Click here: Follow me on Facebook: Follow me on Twitter: Donate to the show here: Audio Production by Podsworth Media: Leave us a review and rating on iTunes! Thanks!

This week, we spin a couple of tunes from Crazy Cavan & The Rhythm Rockers in tribute to Cavan Grogan's passing on February 15th, 2020.  We'll also hear a couple of covers from Levi Dexter and Boz Boorer.  We spin new tracks from Erin Viancourt, OC Hurricanes, Jay Hardtke & The Irregulars (with guest Jim Heath Reverend Horton Heat), The Sparks Boys, Miss Tess, Vince Ray's Loser Machine, Nick Shoulders, The Danny McVey Trio as well as Agent Octopus in our instru-Mental Breakdown that also features a track from Ashley Kingman.  Plus, we board the Rockabilly N Blues Time Machine and hear a selection from the Jammin' James Jukebox! Intro Voice Over- Rob "Cool Daddy" Dempsey Intro Music Bed: Brian Setzer- "Rockabilly Blues"   OC Hurricanes- "My Love" Nick Shoulders- "Ding Dong Daddy" The Danny McVey Trio- "Knight Of The Night"   instru-Mental Breakdown: Ashley Kingman- "Roughneck City" Agent Octopus- "Cape Fear"   Miss Tess- "Gamblin' Man" Erin Viancourt- "Cowgirl" The Sparks Boys- "Upside Down" Jay Hardtke & The Irregulars- "Girl Can't Dance" (with Jim Heath aka "Reverend Horton Heat") Vince Ray's Loser Machine- "Rockers Rule"   RIP Cavan Grogan (Feb. 18, 1949- Feb. 15, 2020): Crazy Cavan & The Rhythm Rockers- "My Own Way Of Rockin'" Crazy Cavan & The Rhythm Rockers- "Who's Gonna Rock Ya?"   Rockabilly N Blues Time Machine Week ending February 22, 1958: #89 Jerry Lee Lewis- "Breathless" #76 The Crickets- "Maybe Baby" #1 The Silhouettes- "Get A Job"   Jammin' James Jukebox selection: Darrell Rhodes- "Lou Lou"   Levi Dexter- "My Little Sister's Got A Motorbike" Boz Boorer- "Teddy Boy Rock 'N' Roll" Rocky Burnette with Darrel Higham & The Enforcers- "Unlucky Blues"   Outro Music Bed: Rocky Burnette with Darrel Higham & The Enforcers- "Green Hills"

Before I jump in to my blog commentary about this episode I want to tell you about a new way you can support the podcast.  If you like what we’re doing here and want to contribute to our efforts to bring our listeners interviews with the very biggest names in Texas, Red Dirt, Country Music and Songwriting click HERE.  With your contributions we plan to offload the audio editing work that Carly now takes care of to an outside source.  If you find it in your heart to help me give Carly a great Christmas gift this year click HERE.  Thanks in advance!   How would you like it if someone called you a “long-haired, tattooed, hippie-freak?”  Well, founding member and frontman of Texas band Eleven Hundred Springs, Matt Hillyer, is O.K. with that terminology. In this episode of the podcast we have a great visit with Matt Hillyer and learn about his history as a musician and songwriter, as well as the origins of the band, Eleven Hundred Springs.  Matt’s life and origin story in music is really interesting.  He started singing and playing in his own rockabilly band at the age of 12!  Matt talks about the influence on his life and music by one of his mentors, Jim Heath aka The Reverand Horton Heat and how Heath’s music/style helped shaped his career. After playing in various other bands and groups, Eleven Hundred Springs became a band in the late 1990’s with Hillyer on guitar & vocals along with handling the songwriting duties, Steven Berg on Bass and Richie Vasquez on drums.  The band has went through various lineups since then, but Hillyer and Berg have remained the mainstays of the group. You can learn more about Matt and Eleven Hundred Springs, AND pick up their latest record, “Here ‘Tis” by clicking HERE! So, without further ado, enjoy the episode! Listen via: The Troubadour Podcast Website Apple Podcasts Google Play Spotify Stitcher Podbean

It's the return of Short Time Shots, a mostly nightly collection of scores and more from around the world of wrestling. I'm your host Jason Bryant, and the only bad jokes I know, are dad jokes. If you grew up in the 80s, you might like my references. Top Results: The first Division I dual meet of the year came and went in sunny San Diego, which is Spanish for something involving a whale. The sixth-ranked Wisconsin Badgers opened up year two of the Chris Bono era with a 31-8 win over Fresno State at the "AFC Duals," which is not a West Coast version of KFC. You know how Carl's Jr. is the Western version of Hardees, well, sorry to disappoint. Seth Gross returned to action with a fall at 133 pounds over NCAA qualifier Gary Joint in probably the dual's most notable match. Wisconsin's ranking as a dual meet squad might be a little lofty. Unranked Army West Point pushed the Badgers to the limit as the Badgers escaped 16-15 as Trent Hillger closed things out again for UW. Navy also beat Fresno State 25-9 before the night concluded with Army West Point beating Fresno State 26-10 on the Battle on the Midway. It was on a BOAT! This episode was actually held up so we could get the final score of that dual and not just fake it. No. 7 Minnesota opened up its season with a 28-9 win over CSU Bakersfield at Maturi Pavilion. The dual saw Manny Rivera return to his old stomping grounds. Top match there was freshman Brayton Lee holding on to beat Russell Rohlfing at 149 pounds. Elsewhere in Division I, Chattanooga topped SIUE 29-14 and Cleveland State beat a pair of Division III teams, John Carroll 27-14 and Case Western Reserve 51-(-1). In Division II, Davis & Elkins won the school's inaugural dual meet against Alderson Broaddus 36-12. Falls were registered by 125-pounder Shawn Moore and 157-pounder John Finnerty. The Senators jumped out to a 36-0 lead in an impressive debut. Hat tip to head coach Jerry Boland, know that guy from years coaching at Camden Catholic down at the Virginia Duals. No. 1 Pitt-Johnstown opened up its season beating East Stroudsburg 38-8. Also in Division III, Brockport blanked Penn State Behrend 50-0, UW-Platteville edged Cornell College 18-16. Isaac Wiegel's fall at 125 proved to be the key bonus points for Mike DeRoehn's Pioneers. My apologies to Jim Heath. Don't worry, it's an inside joke. In the NAIA, Jamestown (N.D.) beat York (Neb.) 42-7 and Midland 48-3. Overseas, no Americans will be wrestling for medals as the first day of Greco-Roman completed at the U23 World Championships in Budapest. On the women's side, Kayla Miracle, a four-time WCWA champion during her time at Campbellsville University, finished with a silver medal in women's freestyle at 62kg. What's on the docket: On Saturday, November 2, we have action at a number of opens, including Michigan State, Jamestown, Rochester - neither of those last two are in New York - as well as finishing off action at the Ithaca Invitational in Division III. There's duals across the country with the big one coming in Blacksburg as No. 9 Missouri faces No. 16 Virginia Tech at noon. LIU makes its return to Division I wrestling as the Sharks are in a quad at Rutgers with Centenary (N.J.) and the aforementioned Mountain Cats of Pitt-Johnstown. Placing Top Six (From The Newsletter): Willie Saylor of Flowrestling probably had the biggest nugget of news on the day, tweeting that Ohio State true freshman Greg Kerkvliet, a Minnesota native fresh off getting hosed at the U23 World Championships, has hit the NCAA transfer portal. Coupled with the recent news that Kyle Snyder left Columbus to train at the senior level in State College, Buckeye fans heads have officially exploded. Thoughts and Prayers to Dan Ransick. While Willie's tweet was deleted 15 minutes later, Flo did re-post the news shortly thereafter. Andy Hamilton of Trackwrestling’s Writing Time feature discusses how injuries and the relaxed hardship rules from the NCAA have changed how wrestlers look at their seasons. Among those featured are Northern Iowa’s Jacob Holschalg and Iowa’s Michael Kemmerer, both All-Americans. Ed Gallo of Bloody Elbow features the college career of Edinboro four-time All-American Gregor Gillespie and why his credentials should also be treated highly in the UFC. Ed’s also written a book, released this past summer on Notre Dame College undefeated four-time Division II champion Joey Davis. Ed’s got some chops, give his stuff a look. HawkeyeSports.com's Chris Brewer pens a solid feature on Iowa's redshirt freshman heavyweight, Tony Cassioppi. In a day where most of the content created by media relations offices centers around quick videos and easily sharable content, Iowa still does the well-written feature. This is no exception. By the way, do yourself a favor and go to HawkeyeSports.com, click on the roster and look for a wild swath of hair in the back row. Then scroll and look for Jeremiah Moody. He has now supplanted Lincoln McIlravy as my favorite all-time Hawk. In other news, the NAIA released its rankings prior to Thursday's competition and Grand View is ranked #1 in the nation. In other news, water, is wet. Speaking of Iowa, Iowa City's West High School announced it was launching a girls wrestling team. This isn't in the newsletter, but I thought it was relevant enough to mention here. Finally, closing the news with more Iowa stuff, The Predicament continues its Inside the Rivalry series with a look at Jesse Sundell. On The Network: The second part of my series focusing on the drop of St. Olaf wrestling in Minnesota is in the feed and featured on The Guillotine.com. What happens when you throw out crap excuses for cutting a sport, and you refuse to talk about it to the media? My wrath. You can get to read those stories and more from Mat Talk Online’s daily wrestling newsletter. Sign up for free at mattalkonline.com/news and get the day’s top stories from around the world in wrestling delivered to your inbox for free. The Mat Talk Online Daily Newsletter is sponsored by Resilite. Short Time Shots is sponsorless. Interested? Give me a shout OR If you'd like to SUPPORT THE SHOW and all the on-demand audio offerings, free newsletters and historical research AND you want to get some of that cool Compound gear, you can support this program by making a small monthly contribution to the network by following this link.. The Short Time Time Wrestling Podcast is proudly outfitted by Compound Sportswear. SUBSCRIBE TO THE SHORT TIME WRESTLING PODCAST Apple Podcasts | Stitcher | Spreaker | iHeartRadio | TuneIn | Google Podcasts | Spotify | iOS App | Android App | RSS (Editor's note: This is always a rough draft of the script of the show, there may be minor errors sprinkled throughout and no, it's not in APA style or anything that resembles a journalistic published work. Some shows will also be devoid of show notes, as they're done on the road from a mobile device).

JIM HEATH This episode features Jim Heath, or most notably The Reverend Horton Heat. Some call him the “godfather of modern rockabilly and psychobilly” but we at Rad Dads call him the “Grand Rad Dad of Rock & Roll”. So as Fat Dave says in the intro, “get comfy, our yourself a tall glass of San Pellegrino and listen to the sermon from the Reverend himself.

Jim Heath on his new album 'Whole New Life' & chat with Steve Jones on Jonesy's Jukebox. Music licensed from Soundstripe.Support the show (https://www.paypal.me/pdxpod)

Jim Heath "Reverend Horton Heat" is our guest on Rockabilly N Blues Radio Hour!  We discuss new band members, some artists he's digging on the scene today, his songwriting approach, the new album Whole New Life and a special request.  We also get the Ameripolitan Music Awards Spotlight with tunes from nominees The Delta Bombers, Kyle Eldridge & The Rhythm Rounders, Kenny Vaughan, Abby Girl & The Real Deal and Jimmy Dale & The Beltline.  Plus, we get NEW tracks from Clint Bradley and The Twilight Drifters!!  There's not one second on this show that you should miss!!! Intro Voice Over- Rob "Cool Daddy" Dempsey   Intro Music Bed:  Brian Setzer- "Rockabilly Blues"   Ameripolitan Music Awards Spotlight: Rockabilly Group nominee: The Delta Bombers- "Top Shelf Woman" Western Swing Group nominee: Kyle Eldridge & The Rhythm Rounders- "I Left My Heart In Avalon" Musician nominee: Kenny Vaughan- "Country Music Got A Hold On Me" Rockabilly Female nominee: Abby Girl & The Real Deal- "I've Got A Feeling" Rockabilly Male nominee: Jimmy Dale & The Beltline- "Mr. Lucky"   Jim Heath interview: Reverend Horton Heat- "Big Little Baby (live) Interview segment 1 Reverend Horton Heat- "Whole New Life" Segment 2 *snippet of "Ride Before The Fall" in outro Los Straitjackets with Reverend Horton Heat- "Down The Line" Segment 3 Reverend Horton Heat- "Hate To See You Cry" Segment 4 Reverend Horton Heat- "Viva Las Vegas" Segment 5 (song request from Jim) Johnny Burnette & The Rock 'N' Roll Trio- "Lonesome Train"   Clint Bradley- "Soul Of The West" The Twilight Drifters- "'Round Curves"   Outro Music Bed- Link Wray- "Rumble On The Docks"

First true episode, with old co-host Jim Heath

In addition to Jay and Cameron's usual news, concert, and album roundups, this week's episode features three interviews! First Jay talks to Jim Heath of Reverend Horton Heat, and then Cameron talks to Red and Righteous Vendetta.

Jim Heath (Reverend Horton Heat) jumps in my car for burgers at Billy Goat Tavern (430 N. Michigan - Lower Level) and conversation about his long and awesome career. You can watch the video of us driving to Billy Goat here!  We chat about: Rev's love affair with Chicago ("What's the number one city in the world? Chicago's either got to be that, or number two") "Let Me Teach You How to Eat" and its hot video Rev's love affair with mid-century American culture The time Rev met Johnny and June Carter Cash The first song Rev learned how to play on guitar The Rev's lyrics (including my personal favorite) Radio has never known what to do with the Reverend Horton Heat The story of "Spooky Boots" Chicago and Texas blues - How both influence and inspire Rev Rev's relationship with BBQ ("It's a great part of Americana") Why Rev enjoys playing music more now than when he was younger The mid-90s era, and the album Reverend Horton Heat worked on with Al Jourgensen ("Liquor in the Front") The Boost Mobile Social Media Message of the Week comes from listener Noah The Rev's relationship with social media Thanks for listening, and tell a friend!

Beer With Bear (Or Any Other Beverage) Episode 37 with Deke Dickerson Hello and welcome once again to another episode of Beer With Bear, Or Any Other Beverage. Your host Bear, along with his trusty crew, George The Producer and Franky The Love-machine, are hanging out with a man known to own a guitar or two, Deke Dickerson! As an artist, composer, archivist and adventurer you may have seen Deke on a few albums, films and bbq joints around the world. It's hard not getting lost in conversation with this guy as you'll hear in this episode. Thank you and please subscribe! ARTIST LINKS: http://www.dekedickerson.com/ GRAPHIC DESIGN: Jeremie Fletcher-Bourcy www.linkedin.com/in/jeremiefletcher THEME MUSIC: Chris Hellking - http://hellkingsucks.com/ POD LINKS: Download - http://traffic.libsyn.com/beerwithbear/Episode__37_-_with_Deke_Dickerson_-_remixed.mp3 Soundcloud - https://soundcloud.com/beerwithbear Instagram - www.instagram.com/beerwithbearpod/ Facebook - www.facebook.com/beerwithbearpod Twitter - twitter.com/beerwithbear Episodes Page - http://beerwithbear.libsyn.com/ YouTube - BWB YouTube Channel

Jim Heath (aka "Reverend Horton Heat") is our guest this hour.  We discuss his stage name, early bands, influences, style, vinyl, latest project REV on Victory Records, touring, playing with Robert Gordon, special requests and lots more!  Listen to this one LOUD!   Intro Voice Over- Rob "Cool Daddy" Dempsey Reverend Horton Heat- "Psychobilly Freakout" Segment 1 Reverend Horton Heat- "Get Rhythm" Segment 2 Reverend Horton Heat- "Rock The Joint" Segment 3 Reverend Horton Heat- "Smell Of Gasoline" Segment 4 Reverend Horton Heat- "Mad, Mad Heart" Segment 5  Reverend Horton Heat- "It's A Rave Up" Segment 6 Robert Gordon- "It's Only Love" Reverend Horton Heat- "Longest Gonest Man" Segment 7 Requests from the Rev: Joe Bennett & The Sparkletones- "Black Slacks" Gene Summers- "Nervous" Jack Scott- "Way I Walk"   www.reverendhortonheat.com/ www.facebook.com/reverendhortonheat www.victoryrecords.com/reverendhortonheat

Please join our guest host Jim Heath as we have some fun with father involvement. Jim's guest will be comedian Elliott Threatt. Also joining Jim and Elliott will be a local Hero of the Hallways, Rich Bartow.

WatchDOGS Radio - SATURDAY MORNING LIVE! LIVE, from Wilmington, NC - It's WatchDOGS Radio! It's time for dads from all across our great country to call in and tell us what you are doing with your kids today. We want to hear about fun summer vacations. We want to hear about your weekend outings. We want to hear about baseball games. We want to hear about how you are taking advantage of the summer to connect with your kids. Our host, Keith Schumacher is on the road in Wilmington, NC and will be hosing the show from the road. Guest Hosts will include Sean Rumble in Minneapolis, MN and Jim Heath in Kansas City, MO. WatchDOGS is the school based father involvement program of the non-profit National Center for Fathering. Go to www.fathers.com/watchdogs for more information.  

While Keith is away on vacation WatchDOGS Radio is being taken over by Sean Rumble, Jim Heath and Chris Danenhauer. The crew will be discussing various topics relating to the WatchDOGS experience.

The Watch D.O.G.S. (Dads of Great Students) Program is the largest school based father engagement program in the nation with over 4000 schools participating. Drive, determination, resiliency, intensity, and humility. Any of these characteristics can be used to describe linebacker Rennie Curran. ?Considered an undersized player by numerous critics going into college, he quickly silenced any doubters by striking fear into the hearts of opposing offenses during his three dominant years as an All-American football player at the University of Georgia. ??Drafted in the third round of the 2010 NFL Draft by the Titans, Curran is a force to be reckoned with in the National Football League. However, to truly understand Rennie Curran as a man, one must look deeper than his playing career. Curran has “The Liberian Dream” tattooed on his left bicep, and rightfully so. He has great pride in his Liberian heritage. This pride was brought on by the hard work and determination he witnessed from his family during their numerous struggles with adversity. Curran’s parents came to America from Liberia during the mid-1980s and remained permanently after civil war broke out in their homeland. During that time, his mother earned a master’s degree in nursing from Emory University, while his father started a shoe repair business. Curran grew up witnessing the sacrifices his family made as they supported and sheltered their Liberian family members and friends during the war. ?Curran’s experiences in life have paved the way for him to become the man that he is today. He still lives his life through the lessons he learned from his family. His on the field intensity and drive to help others is a testament to that. He currently spends much of his time with his daughter, Eleana, giving her the same love he received as a child. Rennie Curran truly is “The Liberian Dream”.

Given the fact it hasn't stopped snowing since last November, we're not too anxious to think about next November but we need to. It's an election year and we have a panel of political reporters to give us a look ahead. Guest: Karen Kasler, Ohio Public Radio/TV, Jim Heath, WBNS, Marc Kovac, Dix News.