Podcasts about Septa

District Attorney Larry Krasner has his fair share of vocal detractors, but his performance at the polls speaks for itself. After a convincing win over challenger Pat Dugan in the Democratic primary, Krasner is all but assured a third term. KYW Newsradio's Pat Loeb explains his appeal to voters and keys to victory. Plus, get analysis of the Mark Dial verdict in the trial of Eddie Irizarry's killing, and hear what riders who depend on SEPTA had to say about the potential impact of its impending doomsday budget. Matt Leon and KYW Newsradio's team of reporters cover these stories and more, including the survival of the Eagles' famed “tush push” and Memorial Day weekend activity tips in Pennsylvania.  00:00 Intro 02:01 How - and why - DA Larry Krasner won the Democratic primary 07:51 Analyzing the Mark Dial verdict in the trial for Eddie Irizarry's killing 14:06 What riders said at SEPTA public budget hearing meetings 19:36 Ahead of Memorial Day, veterans continue to wrestle with mental health struggles 23:57 The “Tush Push” LIVES! 30:02 Where to go in PA this Memorial Day and into the summer Listen to The Week in Philly on KYW Newsradio every Saturday at 5am and 3pm, and Sunday at 3pm. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Host Cara Corridoni discusses the latest developments in WC including the impact of Septa budget cuts, big plans for Dolce Zola owners and West Chester University's graduation.

12 - What's with this guy's hair? 1205 - Returning to the 4th of July parade in Whitemarsh being canceled over security concerns. Why cancel all of this tradition? Sign the petition to reinstate the parade! What is the breakdown of Democrats vs Republicans on their local town council. 1210 - Pete Rose and Shoeless Joe Jackson are reinstated into baseball, posthumously. How did Trump play a factor in this? Why is a local pundit so upset about it? 1215 - Side - all time spin-off/sequel 1220 - Why must the government continuously get in our way, even at the local level? 1235 - Senate President Pro Tempore Kim Ward joins the program today. What does she think about the Democrats opposing the “Save Women's Sports Act” in the state house? As a western PA resident and leader, what does she think about SEPTA asking for more funding from the state? Why is the legalization of marijuana bill in the Commonwealth “fake”? Why would a "state store” approach not work? What will happen with Medicaid in the state? 1250 - Why is Jack Cittarelli such a large underdog for NJ governor? Your calls. 1 - NJ Republican Gubernatorial candidate Jack Cittarelli joins us. How's the tan coming along? Is it gravy or sauce? What is the biggest sticking point for Jack and his campaign that he would like to address today? Is Mikie Sherrill offending veterans by lying about her rank in the service? Will there be sanctuary cities in Jersey under his reign? What else would Jack implement on Day 1? How big of an issue is it to get the “handcuffs” off of our police so we can combat non-violent crimes? 110 - Why cancel a parade with no credible threats? Is Trump changing the rhetoric of the Republican Party? Trump's second assassination attempt suspect is in court today. 120 - Is Salma Hayek on the cover of Sports Illustrated a plus for women? 135 - How are Democrats' ideals making local Bucks towns less safe? Why don't you talk to Sheriff Fred Harran about safety? 145 - Famed Hollywood actress Helen Hunt joins us today. Which of her awards is she most proud of, the Oscars or the Emmys? Which would she say is tougher? What's her favorite role? What's her take on Paul Reiser? Are these rumors from the set of ‘Twister' true? Are love scenes difficult? What is the most popular things fans want to talk about with helen when they meet her? Helen personally witnessed 9/11? 155 - Recapping the Helen Hunt interview. 2 - What should be done about taxes in New Jersey? An in-depth discussion on taxes from Dom. Will Jack Cittarelli change all of that? Will the big beautiful bill change things? 215 - Dom's Money Melody! 225 - Revisiting the safety argument in Bucks and Montgomery counties. 235 - Sheriff Fred Harran joins us after a public official compares Fred's plan to that of Hitler's. Is his podcast out yet?Why is getting illegal immigrant criminals out of the county so controversial? Why is the local media exploiting longstanding relationships with the federal government as new when they have been in communication for years? Fred asks if someone can stop telling personal stories at public events! 250 - The Lightning Round!

12 - What's with this guy's hair? 1205 - Returning to the 4th of July parade in Whitemarsh being canceled over security concerns. Why cancel all of this tradition? Sign the petition to reinstate the parade! What is the breakdown of Democrats vs Republicans on their local town council. 1210 - Pete Rose and Shoeless Joe Jackson are reinstated into baseball, posthumously. How did Trump play a factor in this? Why is a local pundit so upset about it? 1215 - Side - all time spin-off/sequel 1220 - Why must the government continuously get in our way, even at the local level? 1235 - Senate President Pro Tempore Kim Ward joins the program today. What does she think about the Democrats opposing the “Save Women's Sports Act” in the state house? As a western PA resident and leader, what does she think about SEPTA asking for more funding from the state? Why is the legalization of marijuana bill in the Commonwealth “fake”? Why would a "state store” approach not work? What will happen with Medicaid in the state? 1250 - Why is Jack Cittarelli such a large underdog for NJ governor? Your calls.

Zach Stone's life arc runs from teenage “knucklehead” to crisis negotiator, trauma-informed facilitator, and head-of-product for thirty health-ed dev teams. In this rich, funny, and occasionally hair-raising conversation we drill down into the how of navigating chaos — on a subway platform, in a corporate boardroom, and inside your own nervous system.Trigger warning: there's a conversation about suicide at about 15 minutes into the episode. Skip to minute 17 if you want to avoid this section.Here's a tasting menu of our conversation:Gang manuals & purple binders – How a Quaker-adjacent conflict resolution course turned a 15-year-old troublemaker into a group dynamics geek.From union hall to board hall – Lessons learned refereeing SEPTA labor fights and why the same “rubber-and-glue” listening works on Zoom stand-ups.OARS in rough water – Using Motivational Interviewing (Open questions, Affirmations, Reflections, Summaries) to defuse rage, whether from a bus driver or the voice in your own head.Simulated danger, real breakthroughs – How well-designed role-plays can heal trauma if you hold the container (and what happens when a participant suddenly starts to undress).Signs you're in a chaotic system – Chronic absenteeism, cortisol tummy, “my work doesn't matter” syndrome, and 70% burnout in tech.Habit > culture – A shout-out to Paul Gibbons, Prochaska & DiClemente, and the myth of top-down culture change.Martial arts as somatic therapy – TaeKwonDo to Muay Thai to boxing; what Zach saw when veterans laid down their canes and kids in shelters stopped fighting.Virtual heartbreak – Coaching a Kharkiv dev team while missiles shook their bomb shelter.Chaos surfing 101 – Why you don't control chaos, you ride it; plus simple team-level practices to build collective resilience.TakeawaysName the elephant first. Start every workshop by voicing the resistance in the room; it evaporates faster than you'd think.Watch for survival mode. Tight shoulders, skipped meals, rolling eyes? Slow down before you roll out another initiative.Move the meat-sack. Five minutes of mindful movement (shadow-boxing, Tai-Chi, hallway laps) resets the neuro-chemistry better than another latte.Change habits, not slogans. Draft tiny incentives that make the preferred behavior the easy behavior; culture follows.Links & ResourcesZach on LinkedIn – the easiest place to connect and geek out about behavioral science.Red Kite Project – trauma-informed organizational change (Charlotte DiBartolomeo).AFSC Help Increase the Peace curriculumBooksPeter Levine – Waking the TigerBessel van der Kolk – The Body Keeps the ScorePaul Gibbons –

(00:00-08:11) Ray Dunne joins the show to talk about his experience at the Broad Street Run yesterday. (08:11-18:36) The show talks about some breaking news in the world of college football- Sherrone Moore is expected to be suspended for 2 games from Michigan State. (18:36-32:45) Alec Bohm has no power for being a 6’5 giant, more Phillies talk

The rate went down slightly, but Philadelphia still saw its second-highest year for drug overdose deaths in 2023. State lawmakers want the owners of Crozer Health — Prospect Medical Holdings — to give back the millions they received to keep the now-closing hospitals open. SEPTA, meet SWEPTA. Also, the 250th anniversary of the country's founding won't be the only thing Philadelphia's celebrating soon.

A popular apple juice sold in Pennsylvania has been recalled. SEPTA is cracking down on fare evaders. The last bear season drew in a pretty big harvest. Lastly, these towns want new residents so bad, they'll pay you to move there.

1 - Do you remember how bad the cab situation was in Philadelphia? And now we want to tax ride sharing to pay for SEPTA? 110 - Are people still really concerned about tariffs and is that Trump's only blemish right now? Why is Amazon showing prices of their products before and after tariffs? Your calls. 120 - Why are most organizations/unions still leaning to the left? Wrong way Bernie! Would you honeymoon in Russia? 130 - SEPTA Transit Chief Chuck Lawson joins the program. Why is Septa's new emphasis on fare evasion? What infrastructure changes can Septa implement to combat stolen fares? What is Chief Lawson looking to implement with a swoon of new officers joining the academy? 150 - Is Bernie disobeying the will of Karl Marx? We talk about the proposed bill to raise taxes on ridesharing in order to pay for Septa.

12 - We kick off the show with the reaction to the Eagles' visit to the White House yesterday. We react to comments from former Eagle Malcolm Jenkins, as well as writers Les Bowen and Marcus Hayes. Is Saquon playing golf with Trump comparable to Reggie White's comments in 1998? Where do Eagles fans stand politically? 1210 - Will Judge Dugan switch over to the Republican side to defeat Larry Krasner? 1220 - A 60 million dollar plane fell off an aircraft carrier while the ship was trying to evade Houthi rockets. How big of an embarrassment is this and why are we not looking to eradicate the Houthis? Side - the/of names 1230 - Tommy Pigitt, Principal Deputy Spokesperson for the Department of State, joins the program today. Why is the President in Michigan to celebrate 100 days? Why is combating transnational crime the biggest emphasis of this White House? How important is it to fight back against radical groups who have overtaken colleges and universities? 1245 - United States Secretary of Housing and Urban Development Scott Turner joins the program. As a former NFL player, what is his take on Saquon playing golf and Jalen skipping out on the visit? What would compel players to not go to the White House? How has it been getting HUD back on track through tearing down regulation and correcting behavior in-house? The price of a starter house today is ridiculous! What can be done? 1 - Do you remember how bad the cab situation was in Philadelphia? And now we want to tax ride sharing to pay for SEPTA? 110 - Are people still really concerned about tariffs and is that Trump's only blemish right now? Why is Amazon showing prices of their products before and after tariffs? Your calls. 120 - Why are most organizations/unions still leaning to the left? Wrong way Bernie! Would you honeymoon in Russia? 130 - SEPTA Transit Chief Chuck Lawson joins the program. Why is Septa's new emphasis on fare evasion? What infrastructure changes can Septa implement to combat stolen fares? What is Chief Lawson looking to implement with a swoon of new officers joining the academy? 150 - Is Bernie disobeying the will of Karl Marx? We talk about the proposed bill to raise taxes on ridesharing in order to pay for Septa. 2 - Legendary Philadelphia Sports Radio Host Angelo Cataldi joins us. Where can we get the book? How was the Joe Conklin Show a few weeks ago and what is it like working with Joe Conklin for 30 years? When did going to the White House to celebrate the Super Bowl become a political issue? Angelo also details how impactful this draft was after losing half the defense off of a championship team. Why is the team's messaging around Dallas Goedert so odd? What is Angelo's take on the Phillies season so far? 215 - Dom's Money Melody! 225 - Is there more than meets the eye with the Real ID issues? 240 - Harvard is doing away with “Affinity Groups”. Your calls on Real ID. 250 - The Lightning Round!

It was a historic visit, just the second ever to Philadelphia by the pontiff, and in the days since Pope Francis' passing, memories of his time here in September 2015 are being cherished that much more fondly. A pair of KYW Newsradio alumni who covered the event look back and ahead as the Vatican prepares to choose Francis' successor. Plus, as Delaware County braces for the imminent closure of two hospitals, residents race to find new medical facilities and resources to serve them. Matt Leon and KYW Newsradio's reporters recap these stories and more of the biggest news in the Philadelphia region this week, including a massive wildfire in Ocean County, NJ; Mayor Parker's housing plan, and the Philly Black Pride celebration. 00:00 Intro 02:00 Memories of Pope Francis' 2015 visit to Philadelphia 09:52 Ocean County wildfire: cause and containment efforts 12:57 Crozer Health system closings leave Delco residents with few good alternatives 18:22 New details on Mayor Parker's affordable housing initiative 23:57 Transit notes: SEPTA sustainability, 30th Street Station renovations  30:03 Philly Black Pride 2025 Listen to The Week in Philly on KYW Newsradio every Saturday at 5am and 3pm, and Sunday at 3pm. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

According to Mike, there are three elements of a good leader. To lead by example, to inspire the people, and to serve the people. If you can't fulfill those duties, you don't deserve to be leadership.We follow up our last conversation with some updates from the ongoing fight to save the Cecil B. Moore Library in North Philly, some commentary on our criminal legal system and the song and dance that is parole. Also, SEPTA's mismanagement problems will be making its way to riders throughout the tri-state who will inevitably be footing the bill. Tap in.------- FOR MORE 2BD, subscribe to our Patreon for exclusive access to additional footage and projects from the team. visit ⁠⁠⁠patreon.com/2BD_exe⁠⁠⁠ for access.2bedetermined.co

1 - Phillies pitcher Matt Strahm debuted a new Declaration of Independence glove. Does Dom know the real significance behind him wearing it? 105 - Returning to yesterday's conversation on SEPTA. Let's stop pretending Philadelphia is safe! Dom rants about the lack of opposition to Larry Krasner and the lack of an endorsement from the FOP. 110 - Your calls. 120 - A debate on asian food. Your calls. Teasing our next guest. 135 - Bow School District parent and plaintiff in the ongoing lawsuit Kyle Fellers and Institute for Free Speech Senior Attorney Del Kolde join us today to discuss their silent protest that displayed female chromosomes on a wristband in support of girls sports remaining for girls. What happened when the authorities got involved with the altercation between the school officials and other concerned parents. Kyle describes the scenes at the soccer match, and Del chimes in with key details. 150 - Who will be the Democrat front runner in 2028?

2 - Senior Research Fellow in the Border Security and Immigration Center at The Heritage Foundation Simon Hankinson joins us to discuss gangs and how they originated. Is Abrego as innocent as the media makes him out to be? Is the symbolism of the “Chicago Bulls” really a thing within these gangs? What is the fatigue level of immigration talks and where the public is on supporting Trump's immigration plan? 215 - Dom's Money Melody! 220 - Which local county is the best at rejecting ICE agents and letting migrants go? More on SEPTA having a special prosecutor not prosecuting crimes. 225 - Your calls. 235 - Jessica M. Vaughan, Director of Policy Studies at Center for Immigration Studies, joins us today to discuss the phony claims that local leaders are making saying they are not “sanctuary counties” when their actions indicate otherwise. What are some of the actions that ICE would like to see local government do in order to communicate that they are holding illegal aliens? Why are local municipalities ignoring instructions from the federal government? 250 - The Lightning Round!

12 - The fight over immigration wages on! Do people regret voting for Trump because of all these deportations? Dom discusses. 1215 - Side - something exotic 1220 - Will the Chinese buy up the PA Turnpike just like they did in New Jersey? Some audio from Trump. Why is it such a big deal? Your calls. 1230 - New Jersey Senator Mike Testa joins the program. Senator Testa begins with why this turnpike ownership is a matter of national security. Why else should we be not dealing with this company? What could an adversary do with your travel routes? What precautions is this company not taking that Mike would like to see? 1250 - We play audio of the mother of Rachel Morin, who was slain by an illegal alien, talking at the White House. Dom reacts 1 - Phillies pitcher Matt Strahm debuted a new Declaration of Independence glove. Does Dom know the real significance behind him wearing it? 105 - Returning to yesterday's conversation on SEPTA. Let's stop pretending Philadelphia is safe! Dom rants about the lack of opposition to Larry Krasner and the lack of an endorsement from the FOP. 110 - Your calls. 120 - A debate on asian food. Your calls. Teasing our next guest. 135 - Bow School District parent and plaintiff in the ongoing lawsuit Kyle Fellers and Institute for Free Speech Senior Attorney Del Kolde join us today to discuss their silent protest that displayed female chromosomes on a wristband in support of girls sports remaining for girls. What happened when the authorities got involved with the altercation between the school officials and other concerned parents. Kyle describes the scenes at the soccer match, and Del chimes in with key details. 150 - Who will be the Democrat front runner in 2028? 2 - Senior Research Fellow in the Border Security and Immigration Center at The Heritage Foundation Simon Hankinson joins us to discuss gangs and how they originated. Is Abrego as innocent as the media makes him out to be? Is the symbolism of the “Chicago Bulls” really a thing within these gangs? What is the fatigue level of immigration talks and where the public is on supporting Trump's immigration plan? 215 - Dom's Money Melody! 220 - Which local county is the best at rejecting ICE agents and letting migrants go? More on SEPTA having a special prosecutor not prosecuting crimes. 225 - Your calls. 235 - Jessica M. Vaughan, Director of Policy Studies at Center for Immigration Studies, joins us today to discuss the phony claims that local leaders are making saying they are not “sanctuary counties” when their actions indicate otherwise. What are some of the actions that ICE would like to see local government do in order to communicate that they are holding illegal aliens? Why are local municipalities ignoring instructions from the federal government? 250 - The Lightning Round!

2 - The SEPTA Board Chair Ken Lawrence joins the program. Dom's big question is “Why?” Why is there such a cataclysmic shutdown looming with SEPTA? How did Ken become the chair? What is being done about crime on the railways? How are the cameras being deployed, will people be manning all of them? Why is SEPTA involving a special prosecutor for quality of life and fare evading crimes? Who commits these crimes? Why is this prosecutor taking so long to get ready to perform their duties? What is Ken's response to the riders that have had trouble in getting on the trains and fares? Why no rides after 9pm? What about having a Dom Giordano Station? 215 - Your calls on the matter and continuing to poke fun at Henry. 220 - Dom's Money Melody! 225 - Leslie gives her reconciliation. 235 - We've got The Dom Giordano Program action figure set! How accurate are they? 240 - Joe Biden makes his first public comments since being forced out of the Presidential race. And picks up right where he left off with his gibberish. 250 - The Lightning Round!

12 - Do ultrasounds cause autism? Does Dan need a birth coach? Is the rise of maternal age causing autism? We play audio of what RFK Jr. is saying on the rise in autism. 1205 - Dom rips the questions being asked of RFK, as it is a leading question for extremists. 1215 - Side - something people do in public you just can't believe. 1220 - Continuing on with the autism talks. Your calls from the field. 1230 - Research Fellow in The Heritage Foundation's Grover M. Hermann Center for the Federal Budget Dr. EJ Antoni joins us today. Are we going to have more manufacturing workers or manufacturing robots if we bring business back stateside? Why is it so important to be developing our pharmaceuticals in house rather than by our adversaries? With the backing of Swiss companies, is it feasible to bring industries like steel manufacturing back? We need more EJ Antoni's advising Trump and going on shows! What are the work-arounds that China is using in order to avoid tariffs and fees? 1250 - Are any athletes on the planet one of the 100 most influential people on earth? This sparks some interesting discussion. 1 - “Turn this plane around!” No! Says Trump. 105 - Is Jesse Watters correct for linking Chicago bulls attire to gang activity? Heated discussion. 120 - Is RFK's hypotheses on autism causes valid? Your calls. 130 - An update on the Bulls gear controversy. Author of "Plan Red: China's Project to Destroy America" Gordon Chang joins the program. What has changed on the tariffs regarding electronics and chips? Is Apple moving their production out of China a good sign for the tariffs? Why have we been turning a blind eye to the slave and forced labor in China? Is the revenue share that comes from China a big enough deterrent from condemning their awful practices? How clever was China's anti-American AI propaganda? What will China's next move be? 140 - Some news on the Governor's mansion arsonist. Where is the Inquirer's coverage on it? None to be found, but let's talk about Paul Revere's ride and Trump! 150 - Introducing your Chicago Bulls! Your calls. 155 - Should soda be allowed on EBT purchases? 2 - The SEPTA Board Chair Ken Lawrence joins the program. Dom's big question is “Why?” Why is there such a cataclysmic shutdown looming with SEPTA? How did Ken become the chair? What is being done about crime on the railways? How are the cameras being deployed, will people be manning all of them? Why is SEPTA involving a special prosecutor for quality of life and fare evading crimes? Who commits these crimes? Why is this prosecutor taking so long to get ready to perform their duties? What is Ken's response to the riders that have had trouble in getting on the trains and fares? Why no rides after 9pm? What about having a Dom Giordano Station? 215 - Your calls on the matter and continuing to poke fun at Henry. 220 - Dom's Money Melody! 225 - Leslie gives her reconciliation. 235 - We've got The Dom Giordano Program action figure set! How accurate are they? 240 - Joe Biden makes his first public comments since being forced out of the Presidential race. And picks up right where he left off with his gibberish. 250 - The Lightning Round!

SEPTA is planning for the worst: severe cuts and fare increases if it doesn't get the $168 million increase included in Governor Shapiro's budget proposal. City Council checked in on the police department's drone program, Kensington Wellness Court, and more in this week's budget hearings. And concerns about ICE caused one of the city's biggest celebrations of Mexican culture to be cancelled. Brian Seltzer and Sabrina Boyd-Surka step in for Matt Leon, catching up with KYW Newsradio's reporters on the biggest news around the Philadelphia region this week. 00:00 Intro 02:01 SEPTA prepares for a 45% reduction in service without more state funding 07:20 The latest from City Hall: drones, food trucks, and more 13:36 El Carnaval de Puebla festival cancelled over ICE fears 17:50 Reggie Jackson's childhood home set to be demolished 22:44 Black Maternal Health Week raises awareness about disparities 29:54 Philly's plans for the 4th of July and America's 250th anniversary Listen to The Week in Philly on KYW Newsradio every Saturday at 5am and 3pm, and Sunday at 3pm. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

A new budget proposal would spell severe service cuts for SEPTA. State police have rolled out new body cameras ahead of time. The Mütter Museum is changing its tune. Finally, this is going to be one sweet film.

Today Ethan and Nic are joined by Sully of Sullyville who is now a regular host! The guys talk about Gaps in SEPTA funding, Translinks plans to build and own their own housing and commercial hubs and the worst urbanist article of the week. Send us a question: radiofreeurbanism@gmail.comPatreon: patreon.com/RadioFreeUrbanism Instagram: https://rb.gy/ezn9rzSully: https://www.youtube.com/@SullyvilleEthan: https://www.youtube.com/@climateandtransitNic: https://www.youtube.com/@nicthedoorLinks: Translink TOD: https://dailyhive.com/vancouver/translink-coquitlam-central-station-park-and-ride-transit-oriented-development-update SEPTA: https://www.rideprt.org/siteassets/inside-the-pa/media-center/press-releases/2025/03202025release.pdf We need sprawl: https://www.nytimes.com/2025/04/10/magazine/suburban-sprawl-texas.html

04-07-25 The Bizarre File #1798 A CEO vacationing on a cruise ship was accused of choking a man and threatening to kill him over barefoot dancing. A man crashed into a grandmother, killing her during child custody exchange. A man turned violent after being denied a free refill at a kids' lemonade stand. A video shows a SEPTA bus driver pushing a vehicle sideways down Roosevelt Boulevard in Philadelphia. All that and more in the Bizarre File!

The state has expanded its spotted lanternfly quarantine. SEPTA has branched out its contactless payment system. The weather this weekend delayed construction on the Pennsylvania Turnpike. Finally, these 100-year-old tortoises just became first-time parents.

It's the Friday News Roundup! The team is talking about a historic drop in crime, with the lowest murder rate in almost 60 years. And the Sheriff's office is back in the news – this time for its connection to a four-car crash that was kept under the radar for months. Host Trenae Nuri also shares some good news with executive producer Matt Katz and Hey Philly newsletter editor Siani Colon – there's a new Kelce, some new (unusual) SEPTA merch, and four new James Beard finalists from Philly.  Our Friday news roundups are powered by great local journalism:  Philadelphia leaders address violent weekend that left 13 shot An SUV assigned to the Philly Sheriff's Office ran a red light and caused a four-car accident. Then, the case disappeared. Blacks make up 66% of Philly's homeless, topping national average. Experts sound alarm for more resources and housing Jason and Kylie Kelce welcome their fourth daughter, go right back to podcasting the next day Philadelphia has four James Beard Award nominees for 2025 Get Philly news & events in your inbox with our newsletter: Hey Philly We're also on Instagram: @citycastphilly  Learn more about the sponsors of this episode: Live Supply Advertise on the podcast or in the newsletter: citycast.fm/advertise Learn more about your ad choices. Visit megaphone.fm/adchoices

This Special Briefing is focused on the future of mass transportation under the new Administration and Congress. Our expert panel discusses the upsurge in construction funded by the Bipartisan Infrastructure Law as well as solutions to hundreds of billions of dollars in budgetary shortfalls facing transit networks from coast to coast. Speakers include Leslie Richards, Professor of Practice at the University of Pennsylvania Stuart Weitzman School of Design and former General Manager & CEO of Southeastern Pennsylvania Transportation Authority (SEPTA), the fifth-largest U.S. transit system; Kurt Forsgren, Managing Director and Sector Lead for Transportation, S&P Global; Randy Iwasaki, President and CEO of Iwasaki Consulting Services, Inc. and former Leader of State and Local Transportation for Amazon Web Services; Polly Trottenberg, who recently served as Deputy Secretary of Transportation under Pete Buttigieg; and David Greising, President and CEO, Better Government Association. Notable Quotes: "All new administrations when they come in, of course, set new policy priorities, but I think this is the first time an administration has tried to cancel or rescope projects in mass that have already been awarded funding through a competitive application process." - Polly Trottenberg "Septa's experienced a huge capital budget crunch as well. And obviously that comes into play with what Polly just described, with the discretionary funds and the uncertainty of what's getting paid out and will get paid out. And what's coming out through formula this year? Septa is facing over a 200 million dollars shortfall." - Leslie Richards "They're preparing for the Olympics. And Mayor Bass has said that the Olympic trips will be not by car. And so they're making a tremendous investment in transit and the airports in LA. I think we have about 85 billion dollars worth of projects ongoing in Region 9, which includes 4 States, and the the only large project that's outside of California is the heart project in Hawaii. So there's investments in California and transit." - Randy Iwasaki "The Democrats, at least on the Illinois Congressional delegation, wrote a letter to the office of management Budget a couple of weeks ago, just simply referencing the the suspension of spending on various programs already approved or anticipated. And they added it up and came up with about 1.9 billion dollars worth of programs." - David Greising "So this sort of strength in taxes and tax support by system operators and by their policymakers and legislators, you know, has been a real strength for credit quality across the sector. In fact, we raised the ratings on about 7 transit operators just in November of last year to reflect the strength and growth that we've seen in this tax support sector." - Kurt Forsgren Be sure to subscribe to Special Briefing to stay up to date on the world of public finance. Learn more about the Volcker Alliance at: volckeralliance.org Learn more about Penn IUR at: penniur.upenn.edu Connect with us @VolckerAlliance and @PennIUR on Twitter, Facebook and LinkedIn Special Briefing is published by the Volcker Alliance, as part of its Public Finance initiatives, and Penn IUR. The views expressed on this podcast are those of the panelists and do not necessarily reflect the position of the Volcker Alliance or Penn IUR.

This episode we discuss the challenges in following the newly published Septa Transit Map. Our featured main topic is all about the past and present happenings to the ever iconic shopping center that is the Mall! Our featured musical guest is Brittany Ann Tranbaugh and we're treated with a special live in-studio performance of a track from her soon-to-be -released new album!

A “strong burning smell” — along with other issues — was reported on a SEPTA train before it caught on fire, but it was allowed to continue operating anyway. Hundreds of people were the victims of a bank fraud scheme that stole more than $30 million. You could get a text telling you why you're stuck in traffic on the turnpike soon. Lastly, Philadelphia's really spoiling America on its 250th birthday.

2 - Bodegas are selling looseys now! But they're not cigarettes, they're eggs! 205 - Should the NJ state government force towns to have marijuana dispensaries? 210 - SEPTA is testing bulletproof cases for bus drivers starting today. Is there a worse run organization in the world than SEPTA? 215 - Dom's Money Melody! 220 - Canadians aren't going down the shore this summer due to protest? 235 - The 5 major TV networks will still hold control of White House events like The Correspondents Dinner, but these lesser outlets will still get their shot. Your calls. 240 - Trump makes a Biden comparison. 250 - The Lightning Round!

12 - New Jersey might be winning the woke race against PA as the NJSIAA says you can be a transgender athlete so long as you declare your gender before the tryout. Isn't this defiance against Trump's executive order? 1210 - Kilmeade hits the nail on the head regarding the slashing of government jobs. 1215 - Side - all-time lists 1220 - Brendan Boyle and a Virginia delegate are making some odd comparisons to highlight what DOGE is doing. How did these schools waste so much of their COVID relief money? 1235 - We welcome Moms4Liberty Co-Founder Tiffany Justice back to the program. We're talking lists! How did these schools spend such an exorbitant amount of the COVID-19 money? How can people share the information on leaders trampling on our rights without coming across as partisan? How does it feel that Mom4Librty has a proverbial target on their backs? 1250 - Your calls to wrap up the hour. 1 - The music of ‘Les Miserable' is under fire as it was played at a white House dinner with trump in attendance. Is it a song he likes aand wanted to hear, or was it the army chorus peacefully rebelling against his regime? 115 - This is the guy who's talking about wage tax? Your calls. 135 - We take a call before our guest on Philadelphia PD waste. Then, we welcome Dan Abrams of “On Patrol”, a show that follows the police and has Abrams and other law enforcement agents break down what is happening in real time. Why bring this show to air? Dom takes Dan through a story of his ride along and how it relates to the tough standards that the police are held to. What is on the horizon for the show? Moving to Krasner talk, what is Dan's sense of where these liberal DA's across the country stand after pushback? What else is Dan doing? 155 - Your calls. 2 - Bodegas are selling looseys now! But they're not cigarettes, they're eggs! 205 - Should the NJ state government force towns to have marijuana dispensaries? 210 - SEPTA is testing bulletproof cases for bus drivers starting today. Is there a worse run organization in the world than SEPTA? 215 - Dom's Money Melody! 220 - Canadians aren't going down the shore this summer due to protest? 235 - The 5 major TV networks will still hold control of White House events like The Correspondents Dinner, but these lesser outlets will still get their shot. Your calls. 240 - Trump makes a Biden comparison 250 - The Lightning Round!

SEPTA's getting ready to debut its new look. Also, here's another reminder to make a rather important update to your license (or at least take note of it for traveling purposes). More tiny homes might be coming to Harrisburg. Lastly, this “hole-in-the-wall' is purportedly the best in state.

Since the Eagles ended the Kansas City Chiefs' streak and became the 2025 Super Bowl Champions, the city has been celebrating all week - from pole climbing on Sunday night to the parade on Friday. We recap the big game and hear from fans. Plus, for Black History Month: some history and a spotlight on people making an impact today in Philadelphia's communities of color. Tan France from “Queer Eye” talks about their “Fab Five Live” tour. And the Philadelphia Flower Show offers special perks for volunteers. 00:00 Intro 02:00 The Eagles' Super Bowl win 10:31 Fans celebrate in Super style 15:37 The legacy of SEPTA's Black trolley operators 20:02 KYW honors GameChangers in Philadelphia's communities of color 25:33 The Fab Five get personal in “Queer Eye” live event 30:03 The Philadelphia Flower Show needs volunteers Listen to The Week in Philly on KYW Newsradio every Saturday at 5am and 3pm, and Sunday at 3pm. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Pennsylvania is one of the states that's been impacted by a massive tuna recall. Also, if you're taking SEPTA tomorrow, officials are asking for you to please have patience. The state PUC is looking for York residents' input on some upcoming projects. Also, RIP, Duolingo owl — you're gone, but not forgotten.

Today on the show the guys remember legend in parking reform Donald Shoup, level crossing dangers, SEPTA cuts for Eagles celebration and Donald trump looking to eliminate NYC bike lanes.Send us a question: radiofreeurbanism@gmail.comPatreon: patreon.com/RadioFreeUrbanism Instagram: https://rb.gy/ezn9rzX(Twitter): https://x.com/RFUrbanism?s=20Alex: https://www.youtube.com/@humanecitiesEthan: https://www.youtube.com/@climateandtransitNic: https://www.youtube.com/@nicthedoorLinks: Donald Shoup: https://parkingreform.org/donald-shoup/ Level Crossing Crash: https://www.threads.net/@kslnews/post/DF-tdshuYMB?xmt=AQGz51Qc1mhwpw8vzZy7y2aBWiebOzFsoJZ_xx2AuXv9kXQSPETA Super Bowl: https://wwww.septa.org/news/super-bowl-parade/ Trump to remove bike lanes: https://cyclingmagazine.ca/sections/news/president-trump-vows-to-remove-bike-lanes-in-nyc/

Steven and Schubes are back in Doylestown* in front of a fun crowd to cover a good chunk of the second book in the Heroes of Olympus series! Topics include: Wawa, Chekov's jelly beans, ring sliding, Pikachu, Percy Jackson and the Gaggle of Mercenaries, pirates, the quiet car, Babe Ruth, airport dads, directions, the BART, McFlurries, SEPTA, Dark Percy, Kingdom Hearts, Admiral Crunch, NPCs, Blake Shelton, The Voice, Amish Country, trap door installations, High School Musical 3, Joel Embiid, mascots, Backyard Baseball, and more.*Philadelphia T(N)OUR: www.thenewestolympian.com/liveThanks to our sponsor, Pretty Litter! Get 20% off + a free cat toy at www.prettylitter.com/olympian  — Find The Newest Olympian Online —• Website: www.thenewestolympian.com• Patreon: www.thenewestolympian.com/patreon• Instagram: www.instagram.com/newestolympian• Bluesky: bsky.app/profile/newestolympian.bsky.social• Facebook: www.facebook.com/newestolympian• Reddit: www.reddit.com/r/thenewestolympian• Twitter: www.twitter.com/newestolympian• Merch: www.thenewestolympian.com/merch — Production —• Creator, Host, Producer, Social Media, Web Design: Mike Schubert• Editor: Sherry Guo• Music: Bettina Campomanes and Brandon Grugle• Art: Jessica E. Boyd — About The Show —Has the Percy Jackson series been slept on by society? Join Mike Schubert as he journeys through the Riordanverse for the first time with the help of longtime PJO fans to cover the plot, take stabs at what happens next, and nerd out over the Greek mythology throughout. Whether you're looking for an excuse to finally read these books, or want to re-read an old favorite with a digital book club, grab your blue chocolate chip cookies and listen along. New episodes release on Mondays wherever you get your podcasts!

Pennsylvania's unemployment rate is below the national average. SEPTA's spending millions on a new payment system. There's an update on the cold snap. Lastly, a WWII finally gets a long overdue honor.

Anti-amyloid therapies provide the first FDA-approved option to alter AD pathology, but an understanding of overall utility and value to patients remains in its infancy. In this episode, Teshamae Monteith, MD, FAAN, speaks with David S. Geldmacher, MD, FACP, FANA, author of the article “Treatment of Alzheimer Disease” in the Continuum® December 2024 Dementia issue. Dr. Monteith is the associate editor of Continuum® Audio and an associate professor of clinical neurology at the University of Miami Miller School of Medicine in Miami, Florida. Dr. Geldmacher is a professor and Warren Family Endowed Chair in Neurology and the director of the Division of Cognitive and Behavioral Neurology, Department of Neurology, Marnix E. Heersink School of Medicine at the University of Alabama at Birmingham in Birmingham, Alabama. Additional Resources Read the article: Treatment of Alzheimer Disease Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @headacheMD Transcript Full interview transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, which features conversations with Continuum's guest editors and authors who are the leading experts in their fields. Subscribers to the Continuum journal can read the full article or listen to verbatim recordings of the article and have access to exclusive interviews not featured on the podcast. Please visit the link in the episode notes for more information on the article, subscribing to the journal, and how to get CME. Dr Monteith: This is Dr Teshamae Monteith. Today, I'm interviewing Dr David Geldmacher about his article on treatment of Alzheimer's disease, which appears in the December 2024 Continuum issue on dementia. Welcome to our podcast, Dr Geldmacher. How are you?  Dr Geldmacher: I'm very well, thank you. It's a pleasure to be here.  Dr Monteith: Yeah. So, why don't you introduce yourself to our audience? Dr Geldmacher: Sure. I'm David Geldmacher. I'm a professor of neurology at the University of Alabama in Birmingham and I lead the division of Cognitive and Behavioral Neurology.  Dr Monteith: So, I'm really excited about this, to personally learn, and I know that or neurology community is also really excited about this interview. So, why don't we start off with your main objective.  Dr Geldmacher: So, my main goal in the article was to review the FDA-approved pharmacologic treatments for dementia. There's lots of ways of thinking about treatment of dementia; psychosocial, caregiver support, and so forth. But I really wanted to focus on the issues of drug treatment because that's what has been our backbone for a long time and now has recently expanded.  Dr Monteith: Why don't we talk a little bit about, first of all, the boom in the field? What's that been like?  Dr Geldmacher: So, the big change in the field is over the last several years, we've had treatments become available that actually attack the underlying Alzheimer pathology, and that's new and different. For decades, we've been able to treat the symptoms of the disease, but this is the first time we've really been able to get to the root of the pathology and look toward removing amyloid plaques from the brain.  Dr Monteith: Let's step back a little bit and talk about the framework of diagnosis and how that leads into the therapeutic potential. I know you're going to dive into some of the biologics, but we should probably talk about the kind of holistic approach to considering the diagnosis. Dr Geldmacher: Sure. So, you know, when someone comes to the clinic with memory complaints, our question we have to ask is, is this neurologic origin, a structural origin like Alzheimer's disease or vascular dementia? Are there complicating factors, the software issues of mood disorders and sleep disorders and pain that can all magnify those symptoms? The clinical reasoning is a critical part of that, but in Alzheimer's disease, typically the problems revolve around difficulty forming new memories of events and activities, the episodic memory. And then it's often accompanied by changes in word finding and semantic knowledge. And those are the things that we look for in the clinic to really point toward an AD diagnosis. And then we support it with exclusion of other causes through blood work and identification of patterns of brain atrophy on MRI. And then most recently in the last couple of years, we've been able to add to that molecular imaging for amyloid with PET scans as well as, most recently, blood-based biomarkers for Alzheimer's pathology. So, it's really been a revolution in the diagnosis over these last several years.  Dr Monteith: And when approaching patients or populations of individuals, there seems to be a real full spectrum with looking at the societal burden, the biological impact, of course, risk factors of primary prevention, and now this whole area of brain health and secondary prevention. How do you kind of tie all of this together when talking to patients and family members?  Dr Geldmacher: Sure. So, the approaches for brain health apply to everyone. In basically every clinic visited, our brain aging and memory clinic, we reviewed lifestyle approaches to brain health like regular physical exercise, healthy diet, cognitive and social stimulation. And those are fundamental to the approach to everyone, whether they have cognitive impairments that are measurable or not. These are all things that are good for our brain health. And then, you know, focusing on the vascular risk factors in particular and working with the patient and their primary care team to ensure that lipids and blood sugar and blood pressure are all in good healthy ranges and being appropriately treated.  Dr Monteith: You know, there's this kind of whole considerations of clinically meaningful endpoints and clinical trials, and even when we're talking to our patients. What would you say the field has kind of identified has the best endpoints in helping patients? Would you call it impaired daily function? Is that like the best hard endpoint? Obviously, there are other things such as caregiver burden, but you know, how do you approach assessing patients? Dr Geldmacher: Defining the endpoints is very difficult. Typically, if we talk to patients and their families, they would like to have better memory or improve memory. How that applies in everyday life actually is daily function. And so, we focus very much on daily function. And when I talk about our therapies, whether they're symptomatic therapies or the new disease-modifying therapies, I really talk about maintenance of function and delays and decline or slowing of decline, helping to foster the person's independence in the activities that they have and be able to sustain that over the longer term.  Dr Monteith: And when thinking about diagnosis- and we're going to get into treatments, but when thinking about the diagnosis, and of course, it's full-spectrum from mild cognitive impairment to moderate and severe forms of dementia, but who should have CSF testing and PET imaging? Obviously, these are invasive, somewhat invasive and expensive tests. Should all people that walk in the door that have memory complaints? How do you stratify who should have tests? Dr Geldmacher: I think about this in a big funnel, basically, and the starting point of the funnel, of course, is the person with memory complaints. Then there's that neurologic reasoning. Are these memory complaints consistent with what we expect from the anatomy of Alzheimer's disease, with atrophy in in the hippocampus and temporal lobe? Do they have episodic memory loss or not? That first step is really trying to characterize, do the clinical patterns act like those of Alzheimer's disease or not? And then we follow the Academy of Neurology guidelines, looking for reversible sources of cognitive decline, things like B12 deficiency and depression, sleep disorders and the like, and try to exclude those. We start with structural imaging with everyone, and MRI, typically, that will help us understand vascular burden and patterns of atrophy, looking for things like mesial temporal atrophy or precuneus atrophy that are characteristic of Alzheimer's disease. If those things are all pointing in the direction of AD as opposed to something else, then typically before moving on to CSF or PET scan, we will use blood-based biomarkers, which are one of the big changes in the field in the last year or so, and there are now multiple panels of these available. The downside is they are typically not covered by insurance. On the other hand, they can really help us identify who is likely to have a positive PET scan or positive findings on CSF. We start to provide that counseling and information to the patient before they get to those more definitive tests. We can push people in the other direction. We can say, your blood-based biomarkers are negative or do not indicate AD as the most likely source of your condition now, so let's treat other things. Let's see what else we can focus on. The blood-based biomarkers are now, in our clinic at least, the critical choke point between the routine workout that we've always done on everyone and then the more advanced workup of proving amyloid pathology with CSF or a PET scan. Dr Monteith: How sensitive are those blood biomarkers and how early are they positive?  Dr Geldmacher: The sensitivity is generally pretty good, in the ninety plus percent range on average and it depends on which panel. And as you point out, when in the course of symptoms that they're done, we know that they become positive and presymptomatic or asymptomatic people. We're using these kinds of markers to screen people for prevention trials. So, I think when someone is symptomatic, they're a good indicator of the presence or absence of AD pathology. Now that doesn't mean the AD pathology is the sole cause of their symptoms. And so, we still need to think about those other things like sleep and mood and so forth. But they do point us in the in the direction of Alzheimer's change.  Dr Monteith: So why don't we talk about some of the more standard older treatments, and it's also important to leave with kind of some rational approach to when we start and what should we be counseling our patients on. So why don't we start with the older, you know, choline esterase inhibitors and then some of the MDA- I guess there's only one modulator, SEPTA modulator. Dr Geldmacher: So, I've been really fortunate in my career span, the time from the first of those symptomatic agents reaching the market in 1993 to seeing the disease modifying drugs enter the market now. I think most neurologists actually have entered practice after those clinical trials of the colon esterase inhibitors were published. So, one of my goals in this article was to review that primary data and what can we expect from those symptomatic drugs. We know that they are inconsistently effective in mild cognitive impairment, and the Academy of Neurology guidelines says there is not strong evidence to use them in mild cognitive impairment. But in mild AD and beyond, the cholinesterase inhibitors provide meaningful benefits. They delay decline, they can delay nursing home placement. They reduce overall costs of care. So, I think they provide real value. So, in the article I have reviewed what the data looked like on those. My approach is to start with oral Donepezil at five milligrams and increase it to ten in everyone who tolerates the five. If for whatever reason the oral Donepezil is not well tolerated, I'll switch to transdermal rivastigmine to help improve tolerability. There are very few head to head comparisons, but nothing suggests that one of the cholinesterase inhibitors is superior to the other for clinical outcomes, and there's no evidence to support conjoint use of more than one at a time. Should someone be showing decline then on typical cholinesterase inhibitor therapy - and people will, it's often delayed, but the decline will reemerge - then I will add the NMDA receptor, a modulator memantine and titrate that up to full dosing, either 10 mg twice a day for the conventional release or 22 mg extended release. And at that point we're sort of on maximal pharmacologic therapy for Alzheimer's disease. These agents can provide some benefit in other conditions, they're off-label except for Lewy body disease where rivastigmine is labeled. But they can provide benefit across different conditions. And there's some preliminary data, for instance, of acetylcholinesterase inhibitors being helpful in vascular cognitive impairment. So, I will use them, but I expect the greatest response when someone really does follow the patterns of Alzheimer's disease.  Dr Monteith: And you have a great chart, by the way, and nice figures looking at some of the meta-analyses on cognitive outcomes as well as functional outcomes. So, thank you for that.  Dr Geldmacher: In general, all of those tables favor treatment over placebo in the domains of cognition, daily function, neuropsychiatric symptoms. And it's that consistency of result that lets me know that we really are seeing a drug effect, that it's not a class effect with those, that we really are helping our patients. It's not like some studies are positive and some are negative. They are very consistently positive. Small magnitude, but consistently positive.  Dr Monteith: And I know we have a lot of patients coming in where, at least, their caregivers are complaining about agitation, and sleep is also a problem for others. And so how do you help that patient? I know you have a good algorithm that also you included in your article, but why don't you summarize how we should approach these symptoms? Dr Geldmacher: Sure. So, for nonpsychotic agitation, you know, just restlessness, wandering, pacing and so forth, my first choice is an off-label use of citalopram. And there is good clinical trials evidence to support that. if someone has psychotic agitation that is with delusions or hallucinations and so forth, I think we do need to move to the antipsychotic drugs. And the one drug that is now approved for treatment of agitation and Alzheimer's disease does fall into that antipsychotic category, along with its various black box warnings - and that's brexpiprazole. For many of our patients, getting coverage for that agent is difficult. It's not on many formularies. So, it is something I progress toward rather than start with. Similarly, for sleep, there is one approved agent for sleep, that's a dual orexin agonist. And it shows effectiveness, but can have some negative cognitive effects, and so I tend not to start with that either. My first choice when sleep is the primary issue for our patients with dementia is trazodone, and there are some small, limited studies for it's off-label used to enhance sleep. It's safe, inexpensive, often effective, and therefore it's my first choice. Dr Monteith: So, now let's get into the big conversations that everyone is having. Let's talk about the newer disease modifying anti amyloid therapies. Give us a summary dating back 2021 probably, although we can hold the preclinical work, but let's talk about what is available to our patients. Dr Geldmacher: Sure. And the development of anti-amyloid therapies goes all the way back to 1999. So, it's a pretty long course to get us to where we are today.  Dr Monteith: Yeah, that's why we limited that.  Dr Geldmacher: With that first approved agent with aducanumab in 2021, it received a limited or accelerated approval in FDA parlance. These agents, the aducanumab, lecanemab and donanemab, all approved, are known to remove amyloid pathology from the brain as measured by CSF and/or BIPET. They are amyloid lowering therapies, often called disease-modifying therapies. And across the agents there's some variable results. But if we look at the two with full approval, lecanemab and donanemab, they slow clinical progression by 25% to 35% on average. And that's measured by either cognitive measures or global measures or composite measures, but it's pretty consistent in that range of about one-third slowing. That makes it really difficult to discern in an individual patient, though, because there's so much variability in the progression of the disease already that it can be difficult to tell in one person that these drugs are working. They're also complex to use, so there's a qualification process that involves MRI to exclude things like a high tendency toward hemorrhage. It includes genetic testing for papal E4 status to help us understand the risk for complication, and then once-monthly or twice-monthly infusions with standardized schedule for MRI scanning. So, there's a lot that goes into managing these agents. And they are expensive, and we don't yet know their cost effectiveness. The cost effectiveness of the cholinesterase inhibitors was questioned when they first came out back in the 1990s, and it took five or ten years to really understand that they provided benefit to society and to individuals in those domains of quality of life and return on investment. And we're still learning about that with the disease modifying therapies.  Dr Monteith: So, two questions. One, the case that you presented was an individual having symptoms and kind of voiced their desire to be on these therapies. So, people are going to be asking, coming to clinic asking and then of course, they're going to be people that you select out. So, how do you make that decision to recommend this treatment for patients given the potential risk? Dr Geldmacher: We've got some really good guidance from appropriate use recommendation papers for aducanumab and lecanemab, and I'm expecting one from donanemab fairly soon. But the key is to identify individualized risks, and that involves knowing their APOE4 status, knowing their- whether they've had microhemorrhages in the brain previously, and then documenting that they really do have amyloid pathology with something like PET scan to establish those baselines. I talk to people about the burden of twice-monthly infusions or, now with donanemab, once-monthly infusions. And for instance, for someone who's got a working caregiver, getting to an infusion center twice a month can be a significant burden. And then if there are complications, frequent MRI scans and so forth. So, we talk about the burden of entering into this therapeutic pathway. The reality is that people who are qualified generally want it. I have relatively few folks who have said, no, these risks are more than I'm willing to accept. For decades my patients have said, anything you can do to slow this down, I'm willing to try. And now we're seeing that translated to reality with people willing to accept high-risk, high-cost treatments with the chance of slowing their individual progression.  Dr Monteith: And how do you select between the two treatments? Dr Geldmacher: So far that's been easy because donanemab's not readily available.  Dr Monteith: Outside of clinical trials, right?  Dr Geldmacher: Exactly. For prescription use, it's coming in - the first cases have now been infused - but it's not generally available. Nonetheless, what I will do for patients in this is look at the risk tables. So donanemab appears to have in general some higher rates of the Aria complications, amyloid-related imaging anomalies, and some people are going to be more risk tolerant of that for the payoff of potentially faster response. The donanemab trials restructured that. They did their first assessment of effectiveness. I had amyloid removal at six months and a significant proportion of people were eligible to discontinue treatment at six months because their amyloid was below treatable thresholds. So higher risk, perhaps faster action and fewer infusions for donanemab. Lecanemab we have more direct experience with, and between the two of them, the eighteen month outcomes are pretty much the same and indistinguishable. So are we in it for a quick hit, or are we in it for the long race? And different patients and different families will have differing opinions on where they want to accept that risk and burden and so forth. But so far, the data don't indicate a lot of difference in their longer-term outcomes. We still have plenty to learn.  Dr Monteith: And so, it sounds like, as you mentioned, we're looking at eighteen months out for kind of a hard outcome, and that there is a lot of variability in response rate. How are you tracking patients- you know about the imaging, so just in terms of clinical outcomes and efficacy?  Dr Geldmacher: Sure. So, for Medicare to reimburse on these treatments, people need to be enrolled in a registry program - and there are several of these, CMS runs one of their own. But the requirement for that is, every six months, to do cognitive and functional outcomes through the first two years. Cognitive outcomes are up to the clinician, but things like the mini mental state exam, the MoCA, are appropriate. In our own program, we use something we developed locally called the Alabama Brief Cognitive Screener. As for the cognitive outcomes and then for functional, we use an instrument called the General Activities of Daily Living Scale, but there are many other ADL scales that could be used as well. CMS does not mandate specific tests. Since the progression of the disease is variable to begin with, we don't really know how to interpret these results in reference to whether the drug is working, but I can tell a patient or a family member, your scores are stable, or, you have a decline of three points in this test. That's typical for this duration of illness. But there isn't a good way to know whether the drug is working in this person at this time, at least with our current levels of data.  Dr Monteith: So, I think we have to talk about health equity, and it sounds like Medicare is reimbursing for some of us. We look at different socioeconomic backgrounds, educational backgrounds, race, ethnicity. Not everyone is aware of these treatments. So, how do we get more patients to become aware of these treatments? And how do we get them to more people to help people? Dr Geldmacher: Yeah, I mean, that's- it's a major, major issue of inequity in our population. We've done some work at UAB looking at the flow of members of minority communities into memory clinics. So, we know that the overall population of, and I'll choose, for an example, blacks and African Americans, that they are represented a much higher rate in our overall UAB treatment population than they are in our memory clinic population. So, they're not even getting to us in the specialty clinic at the same rates as other segments of our population. We also know that blacks and African Americans in our population are not receiving PET scans as often as the overall treatment population. So yes, there are real, real problems with access. There are cultural issues behind this as well. And in many communities, a change in cognition, a loss of memory is an expected part of the aging process rather than recognized as a disease. So, people who come to us from minority communities are often further along in the course of cognitive and functional decline and beyond the point where they might qualify for the disease-modifying therapies, where early AD is the sort of defining boundary. So, I think more awareness and more screening in primary care settings, perhaps more community outreach to let people know that changes in memory that affect daily function are not normal as part of the aging process and should be evaluated for intervention. So, there's lots of places in our healthcare community where we could foster better outreach, better knowledge to get more folks access to the medicines. And this is before we even get to cost. Dr Monteith: Yeah, yeah. And obviously, there's some stigma as well.  Dr Geldmacher: That's right.  Dr Monteith: Really recognizing what the issues are and diving and asking those questions and funding research that asks those questions, as you mentioned, is really important. And then you have also a nice area where, you know, looking on the impact of treatments on caregiver-related outcomes, and of course ultimately want to keep patients out of nursing homes and prevent death. And so, can you talk a little bit about that? And, you know, mainly the caregiver burden.  Dr Geldmacher: So, my research in that area goes back a long way now. But I learned early in the course of therapy that many times the outcome that the family is noticing for symptomatic therapies is not a change in the patient's memory per se, but that there is less work involved in the caregiving. Less time is spent in direct caregiving roles. The patient may shadow less and because they have better independent cognition. I remember one family member once told me, the medicine you started is a godsend because now I can go to the bathroom by myself and he's not pounding on the door saying where are you, where are you. He's able to recall long enough that I'm in the bathroom that I have that moment of privacy. That was very meaningful to me to hear that. So. Dr Monteith: Cool. So why don't you just help us wrap this up and just give us, like, three main takeaway points that we should be getting out of your article? Dr Geldmacher: The three points that I would emphasize from my article is that the symptomatic therapies provide meaningful benefits and measurable, consistent, meaningful benefits. The second is that those benefits extend beyond things like cognitive test scores and into things like caregiver well-being and maintenance of independence in the home environment. And the third is that the disease-modifying therapies are an exciting opportunity to modify the pathology, but we still are learning about their cost effectiveness and their long-term benefit both to individuals and to society. But the only way we're going to learn that is by using them. And that was the experience that we gained from the symptomatic therapies that took use in the community for years before we really began to understand their true value. Dr Monteith: Thank you. That was excellent. And I put you on the spot, too.  Dr Geldmacher: No problem.  Dr Monteith: Again, today I've been interviewing Dr David Geldmacher, whose article on treatment of Alzheimer's disease appears in the most recent issue of Continuum on Dementia. Be sure to check out Continuum audio episodes from this and other issues. And thank you to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, associate editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in depth and clinically relevant information important for neurology practitioners. Use this link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at contentpub.com/AudioCME. Thank you for listening to Continuum Audio.

After SEPTA officially took over from the defunct Philadelphia Transit Company, Transit Workers United Local 234 had to fight for their next contract, facing opposition from the city, state, and even their own union.Support the showwww.laborjawn.com

By the time November came around, Pennsylvanians - especially those in the Philadelphia area - could probably recite certain political ads by heart. That's how much money was being poured into advertising in the crucial swing state leading up to the 2024 election. In the finale of The Week in Philly's two-part “year-in-review” series, we examine the factors that transformed PA from blue to red. Plus, we revisit other defining stories from a tumultuous year - from on-campus protests in the wake of the Israel - Hamas War to multiple crises that nearly sent SEPTA off the rails. Hosted by KYW Newsradio's Matt Leon. 00:00 Intro 02:01 A dramatic year in PA politics 07:18 And highlights from an important year in Jersey politics, too 13:53 SEPTA nearly goes off the rails 19:14 Protests put Penn at heart of controversy 24:14 Grappling with antisemitism and Islamophobia  29:55 A partial eclipse of the city Listen to The Week in Philly on KYW Newsradio every Saturday at 5am and 3pm, and Sunday at 3pm. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

OMG WTF PAX Early access and bonus content on Patreon Subscribe to our monthly gaming newsletter Join the Discord We spent three days in Philly at Pax Unplugged. We suffered behind SEPTA buses that blocked intersections, had some pizza stolen, and were verbally accosted by someone claiming to be the Son of God. But the rest was fun and games. We got to hang out with our friends at Nomnivore Games, reconnect with Mage Hand Press and Flagbearer Games, see Potion Slingers' new video game demo, and meet a bunch of new people. Josh is using up the last of his Goblins and Growlers sick time for 2024, so Inver and I walked through the ins and outs of this year's Pax Unplugged with some observations about how it was different from last year and what that might mean for the industry overall. Be sure to check out the Patreon-exlusive Deep Dives on this episode where we dig into some of the economic and business conditions that could affect the industry in 2025. And, no, despite my best efforts, I could not find Xavier Woods anywhere this year. He must have known I was looking. But I did get to once again trade Dusty Rhodes impressions with streamer Captain Robear and this seems to be solidifying as the cornerstone of our relationship. Check us out on Patreon (http://www.patreon.com/goblinsgrowlers) for additional Deep Dive videos along with early access to the video and audio of the podcast. And don't forget: Telephone, Telegraph, Tell a Friend about the Goblins and Growlers Podcast. LISTEN, RATE, AND SUBSCRIBE! If you like the show, please tell a friend about it. And if you want to tell more people, then please leave us a review on Apple Podcasts and/or your podcatcher of choice. You can find and/or support us at all the places below: https://patreon.com/goblinsgrowlers https://facebook.com/GoblinsAndGrowlers https://goblinsandgrowlers.podbean.com (and basically any other podcatcher) https://quidproroll.podbean.com (our sister podcast, the best narrative play) The Goblins and Growlers Podcast is produced by Goblins and Growlers, a Richmond, Virginia-based tabletop-roleplaying game content and events company dedicated to inclusivity through TTRPGs.

1 - Where should Tom Homan start with deporting illegal immigrants? Your calls. 120 - More of your calls and discussing the drones. Will this drone nonsense continue through Christmas? 130 - We take more of your calls as we wait for our guest. 135 - Philadelphia Councilman Mark Squilla joins us today to discuss the fight for the new proposed Sixers arena. Mark compares this arena to a casino put in years ago that had no support, but then they reached out to the community in order to gain support, and implores the Sixers to do the same. What will transportation look like and what amenities will be provided in order to deter driving into that part of the city? Does Mark have faith that SEPTA will be able to uphold all the travel and keep citizens safe? How will this affect Kensington and its citizens?

12 - Biden uses his executive power to pardon 18,000 non-violent offenders, but the problem is that he's releasing crooked judges who put undeserving children in jail for money. 1205 - We return to the drone conversation that has captured the attention of the nation. 1210 - What makes you a minority group? More on the Sixers arena. 1215 - Side question - Ritual/Superstition 1220 - Are the rest of the pundits on CNN serious with their Caitlin Clark race comments? Your calls. 1230 - Will Daniel Penny get cheers at the Army-Navy game? 1240 - Your calls. Is the rage intensifying or are the gaslighters winning over the drone debate? 1250 - Your calls to finish out the hour. An update on a Caller of the Year matchup. 1 - Where should Tom Homan start with deporting illegal immigrants? Your calls. 120 - More of your calls and discussing the drones. Will this drone nonsense continue through Christmas? 130 - We take more of your calls as we wait for our guest. 135 - Philadelphia Councilman Mark Squilla joins us today to discuss the fight for the new proposed Sixers arena. Mark compares this arena to a casino put in years ago that had no support, but then they reached out to the community in order to gain support, and implores the Sixers to do the same. What will transportation look like and what amenities will be provided in order to deter driving into that part of the city? Does Mark have faith that SEPTA will be able to uphold all the travel and keep citizens safe? How will this affect Kensington and its citizens? 2 - Mayor of Mine Hill, NJ Sam Morris joins us. What is his and his constituents take on these drones flying across the area? Does he have any sense how long these drones linger throughout the night? Why are we not tracking these things, at the least? What is Mine Hill known for? What is his response to the latest reports? 215 - Money Melody! 220 - Winner! 230 - Columnist Gerald Posner joins us today to break down his newest opinion piece “Republicans Can Save Women's Sports”. Dom and Gerald discuss the problems that will be faced by the new administration in keeping women's sports for women. What does he feel RFK Jr. will bring to the table if he is sworn into the cabinet. What do we think of some of his comments regarding classified documents, especially as they pertain to his uncle's assassination? What else is coming down the pipeline in Gerald's work? 240 - Your calls 250 - Lightning Round!

This week we're back at the Mpact conference in Philadelphia and joined by Ruth Miller of Jawnt. Ruth shares her superhero origin story and how employer transit pass programs like SEPTA's Key Advantage Program work to support employees, agencies, and the region overall. +++ Follow us on Bluesky, Threads, Instagram, YouTube, Flickr ... @theoverheadwire Follow us on Mastadon theoverheadwire@sfba.social Support the show on Patreon http://patreon.com/theoverheadwire Buy books on our Bookshop.org Affiliate site!  And get our Cars are Cholesterol shirt at Tee-Public! And everything else at http://theoverheadwire.com

Your SEPTA Key card does more than just get you on your train, bus, or trolley. It comes with a load of discounts to restaurants, museums, and shops. Host Trenae Nuri and Abby Fritz, City Cast Philly producer, dish on the ways you can save just by flashing your SEPTA Key card. Here are the discounted spots referenced in the show:  Federal Donuts Greene Street Coffee Company  The Franklin Fountain and The Franklin Fountain Ice Cream Bar Kismet Bagels Campo's  Hatch & Coop   The Franklin Institute  Philadelphia Museum of Art Museum of the American Revolution The Academy of Natural Sciences  Wilma Theater  Arden Theater  Beyond the Bell Tours  Betsy Ross House  Ghost Tour of Philadelphia  Philadelphia Zoo Ten Pennies Florist SEPTA Store A Novel Idea New Era Phillies Team Store Rothman Orthopedics Ice Rink- Christmas Village Find out about more SEPTA perks here. Want some more Philly news? Then make sure to sign up for our morning newsletter Hey Philly. We're also on X and Instagram! Follow us @citycastphilly. Have a question or just want to share some thoughts with the team? Leave us a voicemail or send us a text at 215-259-8170. Learn more about the sponsors of this episode:  Jones Dairy Farm Interested in advertising with City Cast? Find more info here. Learn more about your ad choices. Visit megaphone.fm/adchoices

Norfolk Southern wants a “Tent City” vacated by January. SEPTA's fare increase has officially gone into effect. Officials have confirmed that the drought won't affect deer hunting this year. Plus, the Farm Show's latest milkshake flavor.

Send us a textIn this “I don't really care, do you?” episode, Ernest unpacks the latest shake-ups in the Trump appointments, Philly 76ers Arena battle, and music industry.Ernestly Speaking! is executively produced and hosted by Ernest Owens. Check him out at ernestowens.com and follow him @MrErnestOwens on Twitter & Instagram.

Caviar bumps? Yep, Center City's got a kiosk for that. Between avoiding a potentially crippling strike to getting a game-changing funding boost from Harrisburg, SEPTA had itself one major week. Before Leslie Richards, the transportation system's general manager, steps down, she reflects on her tenure in an exclusive interview. Plus, more on how recent rain will impact the ripple effects of the region's lengthy drought, and what you can do to help save local dogs at risk of being euthanized. Matt Leon and KYW's reporters give us the rundown of the biggest news in the Philadelphia region this week. 00:00 Intro 02:02 SEPTA's big week 07:52 SEPTA's outgoing GM Leslie Richards reflects 13:02 A key sticking point for new 76ers arena 18:33 Let it rain! 24:03 How to save dogs from being euthanized 30:04 Caviar bumps in Center City Listen to The Week in Philly on KYW Newsradio every Saturday at 5am and 3pm, and Sunday at 3pm. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

It's the Friday News Roundup! We're talking about the hearings on the proposed Center City basketball arena, the deal that averted a SEPTA strike, and the questions surrounding the shooting death of Robert Jones by an off-duty cop. We also have news on behind-the-scenes drama with the Sixers and a loud karaoke taxi driving around town that's bringing both joy and distress. Host Trenae Nuri is joined by Matt Katz, executive producer of City Cast Philly, and producer Abby Fritz.  Our Friday news roundups are powered by great local journalism:  Chinatown advocates tell City Council 76ers arena would push neighborhood 'toward the precipice' City Council needs to take the Sixers arena proposal seriously | Editorial Man shot and killed by off-duty Philly homicide detective was unarmed, sources and family's lawyer say A karaoke taxi has come to town but some want the plug pulled on the Center City attraction SEPTA strike averted in last-minute deal with transit workers union How is SEPTA funded? Inside the Philadelphia transit agency's budget – and what's behind the "death spiral" Shapiro says he won't let SEPTA ‘fail' as struggling transit agency warns of looming cuts Want some more Philly news? Then make sure to sign up for our morning newsletter Hey Philly. We're also on X and Instagram! Follow us @citycastphilly. Have a question or just want to share some thoughts with the team? Leave us a voicemail at 215-259-8170.  Learn more about the sponsors of this episode: Luray Caverns  Interested in advertising with City Cast? Find more info here. Learn more about your ad choices. Visit megaphone.fm/adchoices

Public transportation commuters throughout the Philadelphia area have been in a state of limbo for the past week, as SEPTA and its thousands of bus, train, and trolley operators continue contract talks. Why is SEPTA “hopeful” a resolution can be reached without a strike? What should riders do if the mass transit company's multiple unions follow through on their threat of a coordinated walkout? Matt Leon and KYW's reporters give us the rundown of the biggest news in the Philadelphia region this week, including a recap of City Council hearings about the 76ers' proposed East Market Street arena, information about holiday scams, and the ripple effects that historic wildfires are having on South Jersey.  00:00 Intro 02:00 Latest on SEPTA union contract talks 06:41 Just how much support is there for 76ers' new arena in City Council? 12:47 Election unknowns linger in PA 18:38 ‘Tis the season to be scamming 25:04 New Jersey wildfires put residents on alert 30:05 Christmas tree season in a drought Listen to The Week in Philly on KYW Newsradio every Saturday at 5am and 3pm, and Sunday at 3pm. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

People across the country started drinking more during the pandemic and haven't stopped. SEPTA might go into a “death spiral.” The largest solar project developed by a Pennsylvanian utility is underway. Lastly, this is the state's favorite Thanksgiving dish.

Over 100 inmates were released from jails as a result of staffing shortages. SEPTA workers might strike as soon as this Friday. A Pennsylvania-based cheesemaker has voluntarily recalled several of its products. Finally, a fast food company is (boldly) expanding into Philadelphia after poking fun of the beloved Philly cheesesteak.

12 - How about this victory? Trump and the Republicans come away with a resounding win in the election last night. What is wrong with Sunny Hostin? 1205 - Why did people care about the transgender issues? It was symbolic of how out of touch the Democratic Party. 1215 - Side - all time comeback and subsequent discussion 1220 - Your calls. 1235 - One of the Mount Rushmore faces of Pennsylvania elections, Jim Worthington of the NAC, joins us to relive his night and his work flipping Bucks County to red. Jim gives thanks to all the other people who helped flip Pennsylvania back to red.He also details how he only got one hour of sleep but was still able to hit the gym and how he has never felt more energetic. 1245 - Is Larry Krasner hearing footsteps? Soros backed DAs went down last night. Will he go after the Mayor? 1250 - More of your calls. 1 - Is he real? He's real and he's spectacular. Scott Presler joins us today. Why didn't Scott want to join us last night? What was Scott doing last night for coverage? How does Scott feel about his corralling of the Amish vote? What are Scott's plans now that the election is over? Will we have a little party to celebrate Scott and all of the work he did? The listeners express their admiration for Scott. 120 - Where will Trump stand on abortion? Will it be as Democrats portrayed or will it be handed back to the states? Does abortion hold as much water with voters as we thought? Will Republicans hold the House? RFK Jr. got into an exchange with an MSNBC reporter over fluoride in our water. 135 - Continuing on with our Mount Rushmore, Captain Sean Parnell joins the program. How does it feel after a big win? How did he convince Republicans to vote by mail? Sean details how he capitalized on Democrats sticking to the same old gameplan. What's the next course of action for Sean? Has Don Jr. slept in the last three days? 145 - Can Elvis hold a flame to Sinatra's “My Way”? Linda Kerns joins us to discuss that and protecting the vote on this day after the election. How were we able to prevent illegal ballots trying to be pushed through at the end? What are the legal procedures taking places right now post-election? Linda spills the beans! 2 - Tim Murtaugh of the Trump campaign joins us to give his review of election night. When did they know it was time to call it? When did Tim think the tide was turned and that they could sweep all 7 battleground states? What was the key massage from the Trump campaigned that brought voters back to the GOP? 210 - Side question calls. 215 - Money Melody! 220 - Winner? 225 - How instrumental was Lara Trump to the winning campaign? 230 - PA Attorney General-Elect Dave Sunday joins us fresh off his big win. Why should an AG be a prosecutor? What will Dave's relationship with Larry Krasner be? What is his stance on the special counsel appointed to oversee the SEPTA case? 250 - Double Lightning Round!