Signal From The Noise: By Podcast Notes

Radiolab: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- How much does knowledge cost? While that sounds like an abstract question, the answer is surprisingly specific: $3,096,988,440.00. That's how much the business of publishing scientific and academic research is worth.  This is the story of one woman's battle against a global network of academic journals that underlie published scientific research. In 2011, Alexandra Elbakyan had just moved home to Kazakhstan after a disappointing few years trying to study neuroscience in the United States when she landed on an internet forum where a bunch of scientists were all looking for the same thing: access to academic journal articles that were behind paywalls. That's the moment the very simple, but enormously powerful, website called Sci Hub was born.  The site holds over 88 million articles and serves up about a million downloads to people in practically every country on the globe. We travel to Kazakhstan to meet the mysterious woman behind it all and to find out what it takes to make everything we know about anything available to anyone anywhere, for free.Special thanks to Vrindra Bhandari, Balázs Bodó, Stephen Buranyi, Ian Graber-Stiehl, Joel Joseph, Noorain Khalifa, Aparajita Lath, Steve McLaughlin, Marcia McNutt, Randy Scheckman Tanmay Singh, Deborah Harkness, Joe Karaganis, Lawrence Lessig, Glyn Moody, and Steven Press. Episode Credits:Reported by - Eli CohenReporting help from - Karishma Mehrotra, Emily Krumberger and Norihelys RamosProduced by Simon Adlerwith help from - Eli CohenOriginal music and sound designed by - Simon AdlerMixing by - Jeremy BloomEdited by - Alex Neason Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Radiolab is on YouTube! Catch up with new episodes and hear classics from our archive. Plus, find other cool things we did in the past — like miniseries, music videos, short films and animations, behind-the-scenes features, Radiolab live shows, and more. Take a look, explore and subscribe! Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.   Leadership support for Radiolab's science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.  

Modern Wisdom: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Alex Hormozi is a founder, investor and an author. Alex's Twitter has been one of my favourite sources of great insights over the last year. Today we get to go through some of my favourite lessons from him about life, human behaviour, psychology, business and resilience. This is really good. Expect to learn how your ego is keeping you poor, why you never need to care about what anyone else thinks of you, why having a life that sucks is actually a blessing, whether most easy opportunities are just distractions, how to conquer your tiny impulses, why you are built to deal with things being hard, how to beat anyone who ever copies you and much more... Sponsors: Website in 10 MINUTES, no coding skills required: https://hostinger.com/modernwisdom (code MODERNWISDOM for 10% off) Get 15% discount on Craftd London's jewellery at https://craftd.com/modernwisdom (use code MW15) Get the Whoop 4.0 for free and get your first month for free at http://join.whoop.com/modernwisdom (discount automatically applied) Extra Stuff: Follow Alex on Twitter - https://twitter.com/AlexHormozi Follow Alex on Instagram - https://www.instagram.com/hormozi/  Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom - Get in touch. Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact/ 

Infinite Loops: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- This week, we're delighted to welcome Ed Latimore back for his second Infinite Loops appearance. Ed is a best-selling author, former professional heavyweight boxer, competitive chess player, Physics graduate, father, and husband. He joins us to discuss stoicism, progress & pain, demonstrating authenticity, being liked vs. being respected, and a whole lot more. Important Links: Ed's Twitter Ed's website Ed's Substack Ed's first Infinite Loops appearance Show Notes: New child; new house; new book How Ed's new book has developed Humor and progress Understanding addiction Being liked vs being respected “Stoicism found me” Is progress possible without pain? “Humans are very bad at the future” Demonstrating authenticity Being cast as a father figure What's next for Ed Ed's three step process for self-improvement “I don't think any situation has ever gotten worse because someone has good manners.” Books Mentioned: The Founders: The Story of PayPal and the Entrepreneurs who Shaped Silicon Valley; by Jimmy Soni The Art of Learning: An Inner Journey to Optimal Performance; by Josh Waitzkin Can't Hurt Me: Master Your Mind and Defy the Odds; by David Goggins The Subtle Art of Not Giving a F*ck: A Counterintuitive Approach to Living a Good Life; by Mark Manson

Pod of Jake: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Keith is the CEO & Co-Founder of OpenStore and a General Partner at Founders Fund. He is an experienced technology executive and entrepreneur, a prolific investor, and a self-described contrarian. Keith previously served as a General Partner at Khosla Ventures. Before that, he was COO at Square and served in influential roles at LinkedIn. He also co-founded Opendoor. Keith began his career in technology as a senior executive at PayPal. He has since invested early in many great companies including YouTube, Airbnb, Palantir, DoorDash, Stripe, Quora, Yammer, Affirm, Eventbrite, and many others. He also served as a Board Member from inception to IPO at Yelp and Xoom. Follow Keith on Twitter @rabois. [0:00] - OpenStore's early momentum and fundraising strategy [5:35] - How an decentralized department store could unlock eCommerce growth [12:33] - Introducing OpenStore Drive and why it is great for Shopify store owners [16:49] - OpenStore's horizontal approach and why Keith believes it is best [18:41] - OpenStore's business acquisition strategy and thoughtful process design [24:09] - How learnings from OpenStore's initial acquisitions have led to improvements [28:56] - Why OpenStore's business is resilient in various macroeconomic environments [35:06] - Acquisition offers and accept rates as metrics and countermetrics at OpenStore [38:45] - Introducing Gumdrop which matches long-tail influencers to long-tail SKUs [41:40] - The advantages of aggregation that benefit OpenStore's business model [45:19] - Building a great company culture; finding & developing undiscovered talent [51:11] - The most high-leverage activities Keith allocates time to as OpenStore's CEO homeofjake.com

The Underworld Podcast ✓ Claim : Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- The biggest drug cartel in the world isn't Mexican, or Colombian. It's Asian. Buried deep in the Burmese jungle are networks of cutting edge meth labs, guarded by rebels and run by kingpins so powerful they make El Chapo look like a corner boy. In 2019, Underworld cohost Sean Williams went looking for one of the billion dollar meth labs spending months on the Mekong, in lawless casinos and hunting a drug industry bigger than any other on earth...and now he's a dad! Learn more about your ad choices. Visit megaphone.fm/adchoices

HBR IdeaCast ✓ Claim : Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- How do you solve the world's toughest problems? Or find the next big thing in tech? Lots organizations fail to explore and take big bets on new ideas because they can't tolerate the mess of experimentation and the fear of failure. At X, Alphabet's dedicated innovation factory, they don't have that problem, and Astro Teller, Captain of Moonshots at X, can explain why. Undertaking projects on everything from rural communication to ocean health to machine learning, he and his teams operate with different creative mindsets and decision-making principles than many of us. He spoke with host Alison Beard at HBR at 100: Future of Business live virtual conference.

Econtalk: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Photographer, author, and visionary Kevin Kelly talks about his book Excellent Advice for Living with EconTalk's Russ Roberts. His advice includes how to have a deep conversation, why it's better to control time than money--and whether, in the end, we should give advice in the first place. Other topics of discussion include the right object of our aspirations, the reason for optimism when it comes to technology, and why Kelly is not worried about AI.

Starting Greatness with Mike Maples: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Startup founders dealt with uncertainty, stress and trauma in the wake of the run on Silicon Valley Bank, but the most important lessons from this crisis never showed up in social media. In this lesson of greatness, Mike Maples, Jr of FLOODGATE calls on the actions of a variety of founders who showed incredible courage and competence to showcase three crucial lessons for founders for how to deal with another potential crisis: Scenario planning, financial agility, and crisis communication.

Artificial Intelligence Podcast: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Sam Altman is the CEO of OpenAI, the company behind GPT-4, ChatGPT, DALL-E, Codex, and many other state-of-the-art AI technologies. Please support this podcast by checking out our sponsors: - NetSuite: http://netsuite.com/lex to get free product tour - SimpliSafe: https://simplisafe.com/lex - ExpressVPN: https://expressvpn.com/lexpod to get 3 months free EPISODE LINKS: Sam's Twitter: https://twitter.com/sama OpenAI's Twitter: https://twitter.com/OpenAI OpenAI's Website: https://openai.com GPT-4 Website: https://openai.com/research/gpt-4 PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:41) - GPT-4 (20:06) - Political bias (27:07) - AI safety (47:47) - Neural network size (51:40) - AGI (1:13:09) - Fear (1:15:18) - Competition (1:17:38) - From non-profit to capped-profit (1:20:58) - Power (1:26:11) - Elon Musk (1:34:37) - Political pressure (1:52:51) - Truth and misinformation (2:05:13) - Microsoft (2:09:13) - SVB bank collapse (2:14:04) - Anthropomorphism (2:18:07) - Future applications (2:21:59) - Advice for young people (2:24:37) - Meaning of life

My First Million: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Episode 436: In a special Friday episode, Shaan Puri (@ShaanVP) gives a special masterclass on his pitch deck that has raised millions from investors. Go to the MFM YouTube channel to see examples. Want to see more MFM? Subscribe to the MFM YouTube channel here. SHAAN'S NEW DAILY NEWSLETTER --> shaanpuri.com ----- Links: * shaanpuri.com/deck * Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel. ------ Show Notes: (01:35) - Title (05:41) - Data/personal story (07:30) - Future vision (10:30) - Hero metric (14:15) - Track record (16:30) - Sweeten the pot ----- Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more. ----- Additional episodes you might enjoy: • #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits • #209 Gary Vaynerchuk - Why NFTS Are the Future • #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto * #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett • ​​​​#218 - Why You Should Take a Think Week Like Bill Gates • Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More • How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More

Knowledge Project: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Visionary technology and business leader Nathan Myhrvold just might be the most interesting person in the world, and in this episode of The Knowledge Project he dives deep into some of the most pressing questions facing our world today. Where will technology take us in the future? Should we trust artificial intelligence? Where have we gone wrong in protecting our planet? How do we reverse the effects of what we've already done? Myhrvold answers all these and much, much more.   Myhrvold is a prominent scientist, technologist, inventor, author, and food photographer, and the former Chief Technology Officer at Microsoft. He's also the co-founder of patent portfolio developer Intellectual Ventures, the principal author of the culinary book Modernist Cuisine: The Art and Science of Cooking, part of a team that won first place at the World Barbecue Championships, and he completed his postdoctoral fellowship under legendary theoretical physicist Stephen Hawking. -- Want even more? Members get early access, hand-edited transcripts, member-only episodes, and so much more. Learn more here: https://fs.blog/membership/ Every Sunday our Brain Food newsletter shares timeless insights and ideas that you can use at work and home. Add it to your inbox: https://fs.blog/newsletter/ Follow Shane on Twitter at: https://twitter.com/ShaneAParrish Our Sponsors: MetaLab: Helping the world's top companies design, build, and ship amazing products and services. https://www.metalab.com Aeropress: Press your perfect cup, every time. https://aeropress.com

Nudge - Marketing Science Simplified✓Claim: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Ever worried about someone stealing your phone at the beach? Well, there's one thing you can do to make your phone 4x safer. It involves using a psychology-inspired principle to change behaviour. On this show, you'll learn what it is, and why it's important to marketers. Today, Nancy Harhut and I will cover five more marketing principles. Plus, I'll share my real-world experiments to reveal which principles work, and which don't.  Try HubSpot for free: https://hubspot.sjv.io/jWq4k6 Consistency experiment: https://bit.ly/3sABZTU Input bias experiment: https://bit.ly/3sEPFgC Framing experiment: https://bit.ly/3TMKgA2 Information gap experiment: https://bit.ly/3DiGasA Authority bias experiment: https://bit.ly/3sF0G1A Nancy's book: https://amzn.to/3DZTl23 Sign up for the Nudge Newsletter: https://www.nudgepodcast.com/mailing-list Take my marketing course: https://science-of-marketing.teachable.com/

Uncommon with Chance Lunceford ✓ Claim : Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Brian Roemmele is in contention for the most interesting man on the internet. That's why I invited him on the podcast. I wanted to discuss his work, his thoughts and philosophy and his propensity for finding fascinating content not found anywhere else. What I got was three hours of unmitigated fascination. Brian was ready to rock-n-roll. His heart and mind opened up and delivered such a lucid and thought-provoking monologue that I was little inclined to say anything. So, I didn't, really. I just let him say what he needed to say. The result was one of the most interesting, coherent and salient testimonies I've ever had the good fortune to witness. Grab a notebook, clear your mind and buckle up. This is a wild ride. I'll bring Brian back on sometime relatively soon, but in the mean time, find him here: Twitter: https://twitter.com/BrianRoemmele Website: http://voicefirst.expert/ Quora: https://www.quora.com/profile/Brian-Roemmele --- Send in a voice message: https://podcasters.spotify.com/pod/show/logocentrifugal/message Support this podcast: https://podcasters.spotify.com/pod/show/logocentrifugal/support

My First Million: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- In a special episode of My First Million, Shaan (@ShaanVP) talks about the nine things he learned from Emmett Shear - CEO of Twitch - who resigned today. Want to see more MFM? Subscribe to the MFM YouTube channel here. SHAAN'S NEW DAILY NEWSLETTER --> shaanpuri.com ----- Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more. ----- Additional episodes you might enjoy: • #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits • #209 Gary Vaynerchuk - Why NFTS Are the Future • #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto * #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett • ​​​​#218 - Why You Should Take a Think Week Like Bill Gates • Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More • How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More

What Got You There with Sean DeLaney: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Kyle Kowalski is the Funder of Sloww.co (one of my favorite websites for synthesized knowledge + wisdom!)  Kyle is an ex-marketing executive turned corporate dropout and solopreneur who found and created his life purpose after an existential crisis. In one sentence, his purpose is synthesizing lifelong learning that catalyzes human development (LFG!!!).   In a nutshell, Kyle is learning why and how to live and publicly sharing what he learns along the way at Sloww.co. Thinking is his passion—but he's not a professor, philosopher, psychologist, sociologist, anthropologist, scientist, or guru. He's an interdisciplinary dot connector across all those humans and many more. Kyle does all the homework—researching, curating, reading, note-taking, summarizing, synthesizing, writing, creating, and sharing. You get all the highlights—so you spend less time on all those things and more time learning, practicing, and mastering.   About Sloww: Sloww shares the art of living with students of life. Sloww currently has a Premium membership with 1,000+ global members, a weekly email newsletter with 10,000+ subscribers, a social media following of 30,000+, and a website with 60,000+ monthly visitors (5,000,000+ lifetime pageviews).   Kyle's 10 Most Life Changing Ideas  Ikigai 2.0 Guidebook   Watch on YouTube About Host Sean DeLaney: For the last 15 years Sean DeLaney has been working at the intersection of elite performance, entrepreneurship and personal development. As an executive life coach, former professional athlete, entrepreneur, investor and podcast host Sean has been helping people discover their untapped potential and live their best life. He has been an advisor to INC. fastest growing companies, has interviewed billionaire business titans and personally coached CEO's and executives. Interested in having Sean coach you? CLICK HERE I've studied hundreds of the world's must successful people and compiled:13 Insights from the World's Most Successful People – Click Here to get access  https://youunleashedcourse.com/ You Unleashed is an online personal development course created by Sean DeLaney after spending years working with and interviewing high achievers.The online course that helps you ‘Unleash your potential'! You Unleashed teaches you the MINDSETS, ROUTINES and BEHAVIORS you need to unleash your potential and discover what you're capable of. You know you're capable of more and want to bring out that untapped potential inside of you. We teach you how. Enroll Today!- Click Here Subscribe to my Momentum Monday Newsletter Connect with us! Whatgotyouthere TikTok YouTube Twitter Instagram 

Learning Leader Show: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Text Hawk to 66866 to become part of "Mindful Monday." Join 10's of thousands of your fellow learning leaders and receive a carefully curated email from me each Monday morning to help you start your week off right... Full show notes at www.LearningLeader.com Twitter/IG: @RyanHawk12   https://twitter.com/RyanHawk12 David Lieberman, Ph.D., is a renowned psychotherapist and the author of eleven books, including the New York Times bestsellers Get Anyone to Do Anything and Never Be Lied to Again. He has trained personnel in the U.S.  Ralph Waldo Emerson wrote: “People do not seem to realize that their opinion of the world is also a confession of character.” A person looks at the world as a reflection of themselves. If they see the world as corrupt, they feel on some level that they are corrupt. If they see honest working people, that is frequently how they see themselves. “How someone treats you is a reflection of their own emotional health and says everything about them and nothing about you.” Speaking negatively behind someone's back orients you to look for the negative in others. Wouldn't we rather spend time with people who seek the greatness in others? “The less emotionally healthy a person is, the more they denigrate the world to accommodate their own insecurities.” Knowledge is not power. Knowledge is a tool. How it is wielded makes all of the difference. Real power is the responsible application of knowledge. Word usage: Let's take the example of giving a compliment. A woman who believes what she's saying is more likely to use a personal pronoun. For instance, “I really liked your presentation.” However, a person offering insincere flattery might say, “Nice presentation,” or “Looks like you did a lot of research.” In the second case, she has removed herself from the equation. The Art of reading the bluff - When a person is bluffing, they are managing others' impressions to convey the “right” effect and serve a personal agenda. Conversely, the authentic person is not interested in how they come across because they are unconcerned with their image. “People who bluff habitually overcompensate, so you can uncover a bluff instantly by noticing how someone tries to appear.” Relationships: Whenever David speaks to couples, he's always on the lookout when the word we is conspicuously absent from the conversation. We are attracted to positivity. It reflects humility. "Humility connects you to the ownership of mistakes." Humility can recognize a weakness in self. The difference between a sociopath and a psychopath: A sociopath has no conscious. They are very dangerous. A psychopath's wiring is off. They were born that way. Life and career advice: Find a passion that contributes to the world. Don't get too caught up in image or ego. "You can be anything. you're good at. as long as they're hiring." -- Chris Rock

Invest Like the Best: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- My guest this week is Trae Stephens. Trae is a partner at Founders Fund and co-founder and Executive Chairman of Anduril. Trae's philosophy can be boiled down to finding good quests, which has led him to investing in businesses that work closely with the government on societally important issues. Clearly, that extends to co-founding Anduril and I would highly recommend listening to my Business Breakdowns episode on Anduril if you haven't already. In this conversation, we discuss the importance of lobbyists, why the high-tech defense firms of the past became stale, and how he hunts for disagreeableness in founders. Please enjoy my conversation with Trae Stephens.   For the full show notes, transcript, and links to mentioned content, check out the episode page here.   Listen to Founders Podcast Founders Episode 136 - Estee Lauder Founders Episode 288 - Ralph Lauren   -----   This episode is brought to you by Tegus, the modern research platform for leading investors. I'm a longtime user and advocate of Tegus, a company that I've been so consistently impressed with that last fall my firm, Positive Sum, invested $20M to support Tegus' mission to expand its product ecosystem. Whether it's quantitative analysis, company disclosures, management presentations, earnings calls - Tegus has tools for every step of your investment research. They even have over 4000 fully driveable financial models. Tegus' maniacal focus on quality, as well as its depth, breadth and recency of content makes it the one-stop, end-to-end research platform for investors. Move faster, gather deep research to build conviction and surface high-quality, alpha-driving insights to find your differentiated edge with Tegus. As a listener, you can take the Tegus platform for a free test drive by visiting tegus.co/patrick.   -----   Invest Like the Best is a property of Colossus, LLC. For more episodes of Invest Like the Best, visit joincolossus.com/episodes.    Past guests include Tobi Lutke, Kevin Systrom, Mike Krieger, John Collison, Kat Cole, Marc Andreessen, Matthew Ball, Bill Gurley, Anu Hariharan, Ben Thompson, and many more.   Stay up to date on all our podcasts by signing up to Colossus Weekly, our quick dive every Sunday highlighting the top business and investing concepts from our podcasts and the best of what we read that week. Sign up here.   Follow us on Twitter: @patrick_oshag | @JoinColossus   Show Notes [00:03:17] - [First question] - Why Trae thinks most high-margin businesses are bad for society [00:04:28] - What would he change to impact energy technology most if he were in charge [00:06:18] - His investing focus on dynamism and mission-driven tech companies [00:09:42] - Analyzing why relatively few people strive to make society-level advancements [00:11:35] - What he's done as a parent to enable his kids to develop passions [00:12:41] - The most noteworthy adventures in his career [00:14:41] - Founding Anduril and what it taught him about the tech industry [00:18:40] - The cutting-edge of defense technologies today [00:21:29] - What Shyam Sankar of Palantir taught him about defense tech [00:23:34] - Why some of the biggest defense tech companies have stopped innovating [00:28:29] - What he and Anduril have learned about sales and scaling in the public sector [00:32:12] - Where lobbyists and decision makers play in to defense tech business models [00:35:22] - His take on Peter Thiel's notion that competition should be avoided [00:38:24] - The importance of being psychologically disagreeable when building a start-up [00:39:54] - The origin story that stands out the most from companies he has interviewed [00:41:12] - How he developed an investor mindset on his unorthodox path to the venture world [00:43:57] - What he has learned from playing supporting roles and aligning with great leaders [00:46:11] - Important but uncommon lessons about entrepreneurship [00:48:21] - Venture investing lessons he's learned from Lauren Gross [00:50:00] - His first VR project and aspirations for the future of VR [00:54:50] - The role of religion and spirituality in his business philosophies [00:59:13] - Why he tries to capitalize on morality as opposed to sin [01:03:57] - The kindest thing anyone has ever done for him

Drive with Dr. Peter Attia: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this “Ask Me Anything” (AMA) episode, Peter focuses the discussion on two topics getting a lot of attention recently. He first dives deep into GLP-1 agonists, most notably semaglutide and tirzepatide, which originally came to market as diabetes drugs but are now being studied and prescribed for weight loss. He walks through the data and compares the effectiveness of the two drugs, the side effects, and perhaps more importantly, his reservations around wide use of these drugs and who he would consider to be a candidate for them. Next, Peter discusses how metformin, another drug originally brought to market for diabetes management, gained popularity as a potential longevity drug even for non-diabetics. Peter gives his take on this possibility and reviews data from a more recent study investigating the question of whether metformin should be used for general “geroprotection.” If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #45 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: The hype around semaglutide, tirzepatide, and other GLP-1 agonists for weight loss [2:30]; Overview of GLP-1 agonists and why these drugs are getting so much attention [6:15]; Defining the term “geroprotective” [13:30]; Semaglutide: background, brand names, indications, and more [15:15]; Tirzepatide: background, brand names, indications, and more [19:15]; How semaglutide and tirzepatide compare in their efficacy in terms of weight loss and other metabolic health metrics [23:45]; Data showing sustained weight loss and improved metabolic metrics with after more than a year of using semaglutide and tirzepatide [29:00]; What happens to body weight when a patient discontinues the medication? [34:45]; Noteworthy side effects of GLP-1 agonists and similar classes of drugs [40:45]; Increased resting heart rate and other concerning trends in patients using GLP-1 agonists [45:15]; Changes in body composition (body fat and lean muscle) in patients on GLP-1 agonists [50:45]; Possible reasons for the loss of lean muscle mass and tips for protecting lean mass [59:00]; GLP-1 agonists and thyroid cancer [1:01:30]; Who might be a candidate for GLP-1 agonists? [1:03:45]; The large financial cost of this class of drugs [1:08:30]; Metformin as a geroprotective drug: origin of the idea that metformin could be a longevity agent even for non-diabetic patients [1:11:30]; A 2022 study on metformin sheds more light on the question of whether metformin should be used for “geroprotection” in non-diabetics [1:21:00]; Peter's current approach with metformin for his patients [1:25:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

A16z Podcast: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- With every new technology, some jobs are lost while others are gained. People often focus on the former, but in this episode we chose to highlight the latter – a highly creative role that emerges alongside AI: the prompt engineer.Until AI can close the loop of its own, each tool still requires a set of prompts. Just like a composer feeds an instrument the notes to play, a prompt engineer feeds an AI a map of what to produce. And if we know anything from music it's that composing great music takes great skill!In this episode we explore the emerging importance of prompting with Guy Parsons, the early learnings of how to do it effectively, and where this field might be going.Will the prompt engineer be more like the highly sought after DevOps engineer, or a proficiency like Excel that you find on every resume? Listen in to hear Guy's take.Interested in the prompt competition? Email us at podpitches@a16z.com.Resources:DALL-E 2 Prompt Book: https://dallery.gallery/the-dalle-2-prompt-book/Find Guy on Twitter: https://twitter.com/GuyPGuy's combining image experiment: https://twitter.com/GuyP/status/1612880405207580672Guy's amorphous prompt experiment: https://twitter.com/GuyP/status/1608475973300948993Guy's space duck: https://twitter.com/GuyP/status/1601342688225525761Prompt base: https://promptbase.com/Lexica: https://lexica.art/ Topics Covered: 0:00 - Introduction01:49 - DALL-E 2 Prompt Book05:29 - Parallel skills06:51 - 80/20 prompting10:16 - New ways of prompting13:44 - Pulling the AI slot machine18:09 - Comparing models21:04 - Requested features26:34 - Learning with AI27:58 - Practical use cases32:08 - A top 1% prompt engineer36:17 - The most popular images Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

Art of Manliness: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- In your journey towards becoming stronger, fitter, and healthier, there often comes a point where you wonder if taking some supplements will help your progress along. But what fitness supplements are actually effective and worth investing in?Here to answer that question is Layne Norton, a powerlifter and doctor of nutritional science who has a passion for debunking health-related myths and promoting evidence-based recommendations. He's also, full disclosure, the owner of a supplement company himself. But I don't have any financial connection to Layne's company and we keep this conversation neutral and high-level. In our conversation, Layne argues that there are three top-tier research-backed supplements to consider — whey protein, creatine, and caffeine — and we unpack how to use each of them for optimal results. We discuss whether plant proteins are sufficient for building muscle, whether it's true that creatine causes bloating, acne, and hair loss, how to best time your caffeine intake to energize your workouts, and much more. At the end of our conversation, Layne shares some additional supplements that seem promising for enhancing your health and fitness.Resources Related to the EpisodeLayne's previous appearance on the AoM podcast: Episode #475 — How to Lose Weight, and Keep It Off ForeverLayne's supplement company: Outwork NutritionAoM Article: A Primer On Muscle-Building Supplements — Which Work and Which Don't?AoM Article: Creatine — A Primer on Its Benefits and UseAoM Article: How to Use Caffeine to Optimize Your WorkoutsAoM Article: Chugging Your Protein — It's Whey Easier Than You ThinkAoM Podcast #285: The Real Science of Nutrition and SupplementsConnect With Layne NortonLayne on InstagramLayne‘s website

Ten Percent Happier with Dan Harris: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Dan flies to Dharamsala, India to spend two weeks in the orbit of His Holiness the Dalai Lama. This is the first installment of a five-part audio documentary series, something we've never done before now. Over the course of the episodes, we talk to His Holiness about practical strategies for thorny dilemmas, including: how to get along with difficult people; whether compassion can cut it in an often brutal world; why there is a self-interested case for not being a jerk; and how to create social connection in an era of disconnection. We also get rare insights from the Dalai Lama into everything from the mechanics of reincarnation to His Holiness's own personal mediation practice. In this first installment, Dan watches as a young activist directly challenges His Holiness: In a world plagued by climate change, terrorism, and other existential threats, is the Dalia Lama's message of compassion practical — or even relevant? Full Show Notes: https://www.tenpercent.com/podcast-episode/dalai-lama-guide-538Other Resources Mentioned:Healthy Minds InnovationsCompassionate Leadership SummitAdditional Resources:Download the Ten Percent Happier app today: https://10percenthappier.app.link/JoinChallengePodSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

My First Million: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Episode 427: Sam Parr (@TheSamParr) and Shaan Puri (@ShaanVP) speak to Ken Rideout (@KenRideout_), one of the world's best masters runners, successful businessmen and entrepreneur. Ken talks about how he overcame addiction, built a lucrative career, forged mental and physical toughness, and where that's going to take him in the years to come. Want to see more MFM? Subscribe to the MFM YouTube channel here. SHAAN'S NEW DAILY NEWSLETTER --> shaanpuri.com ----- Links: * Teddy Atlas Podcast * Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel. ------ Show Notes: (00:23) - Why Ken is blowing up (12:25) - His finance background (23:45) - Ken's Struggles with Addiction (25:40) - How he got into running/media (31:25) - Who are the toughest people you have met? (38:20) - How to deal with adversity (41:50) - Story of Ken talking smack to Lance Armstrong (44:30) - How does he make money? (53:35) - Does this level of activity increase longevity? ----- Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more. ----- Additional episodes you might enjoy: • #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits • #209 Gary Vaynerchuk - Why NFTS Are the Future • #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto * #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett • ​​​​#218 - Why You Should Take a Think Week Like Bill Gates • Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More • How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More

Aarthi and Sriram's Good Time Show ✓ Claim : Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- In this episode, the gang gets back together! Marc Andreessen and Steven Sinofsky are back to talk about all things AI. We cover the rise of ChatGPT, Bing's AI powered chat Sydney, AI ethics, sentience, whether AI will take over jobs, the economic impact, AI startups vs tech incumbents, and whether it is time for AI to become sentient. This was an incredibly fun episode! Marc Andreessen is an American entrepreneur, venture capital investor, and software engineer. He is the co-author of Mosaic, the first widely used web browser; co-founder of Netscape; and co-founder and general partner of Silicon Valley venture capital firm Andreessen Horowitz. Steven Jay Sinofsky is a former president of the Windows Division at Microsoft. He was responsible for the development and marketing of Windows, Internet Explorer, and online services such as Outlook.com and SkyDrive.

Knowledge Project: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- In the third installment in a series of episodes, The Knowledge Project curates essential segments from five guests revolving around one theme: leadership. This episode helps put a unique definition on leadership and examines whether or not good leaders are context-dependent, the differences between a great leader and an average leader, how great leaders should balance feedback, the difference between being right and doing right, a playbook for managing teams, and the importance of radical candor. The guests on this episode are author Jim Collins (Episode 61, 110), author and leadership expert Jennifer Garvey Berger (Episode 43), co-founder of the Admired Leadership Institute Randall Stutman (Episode 96), the President and COO of Athletic Greens Kat Cole (Episode 117), the former CEO of Ford Alan Mulally (Episode 151), and co-founder of the Conscious Leadership Group Diana Chapman (Episode 130).   -- Want even more? Members get early access, hand-edited transcripts, member-only episodes, and so much more. Learn more here: https://fs.blog/membership/ Every Sunday our Brain Food newsletter shares timeless insights and ideas that you can use at work and home. Add it to your inbox: https://fs.blog/newsletter/ Follow Shane on Twitter at: https://twitter.com/ShaneAParrish Our Sponsors: MetaLab: Helping the world's top companies design, build, and ship amazing products and services. https://www.metalab.com Aeropress: Press your perfect cup, every time. https://aeropress.com

Overthink ✓ Claim : Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- To be or not to be? That is the question. At the center of Hamlet's soliloquy is the issue of whether life is worth living. In episode 72 of Overthink, Ellie and David consider this issue with philosopher and existentialism expert Céline Leboeuf. How can we find meaning in our lives when the world seems random and indifferent to our interests? Leboeuf talks about how her personal experience with an existential crisis and her philosophical search for a way out of it led her to consider religious, atheist, and spiritual answers to the question "Why Live?" Ellie and David also consider Camus' notion of the absurd, and whether life is just a series of blips of suffering with no higher purpose.Works Discussed Albert Camus, The Myth of Sisyphus William James, “Is Life Worth Living”Céline Leboeuf, "Why Live? The Three Authors Who Saved Me During an Existential Crisis"John Jay McDermott “Why Bother: Is Life Worth Living?”Samuel Scheffer, Death and the AfterlifeLeo Tolstoy,  A Confession Patreon | patreon.com/overthinkpodcast Website | overthinkpodcast.comInstagram & Twitter | @overthink_podEmail |  Dearoverthink@gmail.comYouTube | Overthink podcastSupport the show

Moonshots and Mindsets with Peter Diamandis ✓ Claim : Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- In this episode, Dakin and Peter discuss tips for new entrepreneurs, how to build a successful company and the power of venture capital for the economy. You will learn about: 04:37 | The story of Prime Movers Lab 22:25 | The 'do's & don'ts' for new entrepreneurs. 35:47 | Ambitious Vs. Conservative: creating balance for your company. Dakin Sloss is a venture capitalist, founder, entrepreneur, and philanthropist. He is the founder and General Partner of Prime Movers Lab, a VC startup that's become the world's leading partner in breakthrough scientific startups. Learn more about Prime Movers Lab. _____________ I only endorse products and services I personally use. To see what they are, please support this podcast by checking out our sponsors: Levels: Real-time feedback on how diet impacts your health. levels.link/peter Consider a journey to optimize your body with LifeForce. _____________ I send weekly emails with the latest insights and trends on today's and tomorrow's exponential technologies. Stay ahead of the curve, and sign up now: Tech Blog _____________ Connect With Peter: Twitter Instagram Youtube Moonshots and Mindsets

Artificial Intelligence Podcast: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Tim Urban is the author of the blog Wait But Why and a new book What's Our Problem?: A Self-Help Book for Societies. Please support this podcast by checking out our sponsors: - House of Macadamias: https://houseofmacadamias.com/lex and use code LEX to get 20% off your first order - Indeed: https://indeed.com/lex to get $75 credit - Athletic Greens: https://athleticgreens.com/lex to get 1 month of fish oil EPISODE LINKS: Tim's new book: https://waitbutwhy.com/whatsourproblem Tim's Twitter: https://twitter.com/waitbutwhy Tim's Website: https://waitbutwhy.com Tim's Instagram: https://instagram.com/timurban Tim's TED talk: https://www.youtube.com/watch?v=Rk5C149J9C0 PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (05:48) - Human history (21:47) - Greatest people in history (29:35) - Social media (36:17) - Good times and bad times (47:48) - Wisdom vs stupidity (49:55) - Utopia (1:04:05) - Conspiracy theories (1:17:16) - Arguing on the Internet (1:37:16) - Political division (1:47:10) - Power games (1:55:09) - Donald Trump and Republican Party (2:12:17) - Social justice (2:34:59) - Censorship gap (2:42:30) - Free speech (2:46:33) - Thinking and universities (2:54:56) - Liv Boeree joins conversation (3:07:15) - Hopes for the future

Drive with Dr. Peter Attia: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Anthony Hipolito is a sheriff's deputy in Hays County, Texas with over 24 years of experience in law enforcement. In this episode, Anthony discusses his work to spread awareness about illicit fentanyl use and the drastic increase in accidental overdoses, especially in young people. Anthony explains the deadly nature of fentanyl, including how many counterfeit drugs are now being laced with deadly doses of fentanyl. He breaks down how fentanyl is being brought to the US and how younger and younger kids are being targeted. Additionally, Anthony discusses his goal of spreading awareness to our communities and provides important advice for what parents can do. We discuss: Anthony's life of service in law enforcement [5:30]; Fentanyl: medical use, recreational use, and the recent rise in prevalence [8:30]; The story of a teenager dying from an accidental overdose of fentanyl [16:30]; The scope of deaths being caused by accidental overdoses (the majority of which are from fentanyl) [23:00]; How young kids are being targeted, and how fentanyl makes it across our borders and gets distributed [28:30]; What happens to a person when they overdose [35:30]; Whether laws around drug possession are helping or hurting, and the need to focus on helping people that feel the need to take these counterfeit drugs [37:00]; How fentanyl is being added to all kinds of drugs that you wouldn't expect [42:45]; What can we do as parents? [47:15]; Narcan: a treatment for opioid overdoses [50:15]; Importance of awareness, having conversations with kids early in life, and other key takeaways for parents [56:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Modern Wisdom: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Richard Shotton is a behavioural scientist, Founder of Astroten and an author. This might not be news to you, but the human brain isn't designed to be rational. There are cheat codes to get the brain to believe strange things, do strange things and change in ways you might not anticipate. Richard has one of the best insights into this world of mental models, psychology, consumer behaviour, principles for advertising and social change. Expect to learn the marketing secret about behaviour change that everyone forgets about, how to make habit formation absolutely seamless, why IKEA is so successful even though they don't make your furniture, a hack that any advertising campaign can use to make it stick in people's minds, how to fix the problem of choice paralysis and much more... Sponsors: Get 10% discount on all Gymshark's products at https://bit.ly/sharkwisdom (use code: MW10) Get 7 days free access and 25% discount from Blinkist at https://blinkist.com/modernwisdom (use code MODERNWISDOM) Extra Stuff: Buy The Illusion Of Choice - https://amzn.to/3XDakP7 Follow Richard on Twitter - https://twitter.com/rshotton  Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom - Get in touch. Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact/ 

Founders ✓ Claim : Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- What I learned from rereading Hard Drive: Bill Gates and the Making of the Microsoft Empire by James Wallace and Jim Erickson.----This episode is brought to you by: Tiny: Tiny is the easiest way to sell your business. Quick and straightforward exits for Founders.----Follow one of my favorite podcasts Invest Like The Best and listen to episode 292 The Business of Gaming with Mitch Lasky and 293 David Senra Passion and Pain !----[4:00] Gates read the encyclopedia from beginning to end when he was only seven or eight years old.[4:00]  Gates had an obsessive personality and a compulsive need to be the best.[5:00] Everything Bill did, he did to the max. What he did always went well, well beyond everyone else.[6:00] You want to maneuver yourself into doing something in which you have an intense interest. —  Poor Charlie's Almanack: The Wit and Wisdom of Charles T. Munger.[7:00] Gates devoured everything he could get his hands on concerning computers and how to communicate with them, often teaching himself as he went.[9:00] A young man with no money and tons of enthusiasm. — The Dream of Solomeo: My Life and the Idea of Humanistic Capitalism by Brunello Cucinelli. (Founders #289)[10:00] He consumed biographies to understand how the great figures of history thought.[11:00] The idea that some people were super successful was interesting. What did they know? What did they do? What drove those kinds of successes?[12:00] Idea Man: A Memoir by the Cofounder of Microsoft by Paul Allen. (Founders #44)[13:00] “I'm going to make my first million by the time I'm 25.” It was not said as a boast, or even a prediction. He talked about the future as if his success was predestined.[15:00] Gates and Allen were convinced the computer industry was about to reach critical mass, and when it exploded it would usher in a technological revolution of astounding magnitude. They were on the threshold of one of those moments when history held its breath... and jumped, as it had done with the development of the car and the airplane. They could either lead the revolution or be swept along by it.[17:00] Bill had a monomaniacal quality. He would focus on something and really stick with it. He had a determination to master whatever it was he was doing. Bill was deciding where he was going to put his energy and to hell with what anyone else thought.[18:00] Don't do anything that someone else can do. — Edwin Land[21:00] You've got to remember that in those days, the idea that you could own a computer, your own computer, was about as wild as the idea today of owning your own nuclear submarine. It was beyond comprehension.[23:00] There would be no unnecessary overhead or extravagant spending habits with Microsoft.[25:00] “Pertec kept telling me I was being unreasonable and they could deal with this guy [Gates]. It was like Roosevelt telling Churchill that he could deal with Stalin.[27:00] Four years in and Microsoft had only 11 employees.[28:00] Gates sustained Microsoft through tireless salesmanship. For several years he alone made the cold calls and haggled, cajoled, browbeat, and harangued the hardware makers of the emerging personal computer industry, convincing them to buy Microsoft's services and products. He was the best kind of salesman there is: he knew the product, and he believed in it. Moreover, he approached every client with the zealotry of a true believer.[29:00] When we got up to 30 employees, it was still just me, a secretary, and 28 programmers. I wrote all the checks, answered the mail, took the phone calls.[31:00] This might be Bill's most important decision ever: IBM had talked to Gates about a fixed price for an unlimited number of copies of the software Microsoft licensed to IBM. The longer Gates thought about this proposal the more he became convinced it was bad business. Gates had decided to insist on a royalty arrangement with IBM.[34:00] You have to be uncompromised in your level of commitment to whatever you are doing, or it can disappear as fast as it appeared. Look around, just about any person or entity achieving at a high level has the same focus. The morning after Tiger Woods rallied to beat Phil Mickelson at the Ford Championship in 2005, he was in the gym by 6:30 to work out. No lights. No cameras. No glitz or glamour. Uncompromised. — Driven From Within by Michael Jordan and Mark Vancil. (Founders #213)[36:00] Overdrive: Bill Gates and the Race to Control Cyberspace by James Wallace. (Founders #174)[42:00] You can drive great people by making the speed of decision making really slow. Why would great people stay in an organization where they can't get things done? They look around after a while, and they're, like, "Look, I love the mission, but I can't get my job done because our speed of decision making is too slow."—Invent and Wander: The Collected Writings of Jeff Bezos (Founders #155)[43:00] Alexander the Great: The Brief Life and Towering Exploits of History's Greatest Conqueror--As Told By His Original Biographers by Arrian, Plutarch, and Quintus Curtius Rufus. (Founders #232)[44:00] Gates was intolerant of distractions.----Join my free email newsletter to get my top 10 highlights from every book----“I have listened to every episode released and look forward to every episode that comes out. The only criticism I would have is that after each podcast I usually want to buy the book because I am interested so my poor wallet suffers. ” — GarethBe like Gareth. Buy a book: All the books featured on Founders Podcast

Huberman Lab: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- In this episode, I discuss the mechanisms by which human eggs and sperm are generated, the ovulatory/menstrual cycle, the conception process and overall fertility in males and females. I also explain how, regardless of whether you seek to conceive children, optimizing egg and sperm health is directly related to vitality and longevity. I cover the nutrition-based, behavioral, supplement-based and prescription approaches to optimizing egg and sperm health, the ovulatory/menstrual cycle and fertility. In addition, I explain lifestyle choices that greatly assist or harm fertility—several of which are very surprising. I provide science-based protocols for those trying to conceive children. The tools and principles I discuss can also improve overall vitality and longevity in all people, regardless of age.  For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Maui Nui: https://mauinuivenison.com/huberman Eight Sleep: https://eightsleep.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Fertility, Vitality & Longevity (00:04:24) Maui Nui Venison, Eight Sleep, Momentous (00:08:20) Eggs & Sperm, Genes, Fertilization (00:18:28) Puberty: Gonadotropin Releasing Hormone (GnRH), Melatonin & Leptin (00:23:38) Onset Trends of Puberty, Odors Effects (00:31:24) Female Puberty, Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH) (00:35:25) AG1 (Athletic Greens) (00:36:34) Ovulatory & Menstrual Cycle (00:40:36) Follicular Phase: Egg Maturation & Ovulation, FSH & Estrogen (00:51:09) Luteal Phase: Progesterone & Estrogen, Menstruation (00:58:14) Ovulation & Libido; Luteal Phase & Malaise; Individual Variability (01:03:14) InsideTracker (01:04:18) Sex Chromosomes, Sperm (01:11:40) Tool: Testicular Temperature & Fertility (01:17:22) Sperm Production, Seminal Fluid, Vasectomy (01:24:07) Sperm Cells, Mitochondria & Motility, Intercourse Frequency & Fertilization (01:28:31) Sperm Production, GnRH, FSH, LH & Testosterone (01:36:21) Ejaculate Quality, Sperm Counts, Fertilization, Ectopic Pregnancy (01:44:14) Tool: Sexual Intercourse Frequency & Fertilization (01:53:24) Tools: Tracking Ovulation, Libido, Lubricants (01:56:42) Fecundability: Egg Quality & Woman's Age, Cumulative Pregnancy Rate (02:08:17) Miscarriages, Chromosomal Abnormalities (02:11:23) Female Fertility: Age, Follicle Testing & Anti-Mullerian Hormone (AMH) Testing (02:18:51) Male Fertility: Sperm Analysis, Age (02:24:52) Fertility & Hormone Analysis, Age (02:29:07) Fertility Effects of Sleep, Cortisol/Stress, Cannabis/Nicotine & Alcohol (02:42:40) Fertility, Sexually Transmitted Infections (STIs), Viral Infection & Cystic Fibrosis (02:47:42) Tool: Testicular Temperature & Fertility (02:51:26) Tool: Phones & Sperm Quality (02:58:06) Deliberate Cold Exposure & Fertility, Testicular Temperature, Cortisol/Stress (03:05:43) Fertility, Exercise & Mitochondrial Health; Intermittent Fasting (03:14:46) Testosterone Replacement Therapy & Sperm Production; Supplements (03:20:36) Sex Determination in Offspring, In Vitro Fertilization (IVF), Sperm Fractions (03:32:23) Postcoital Female Position & Fertilization, Sperm Quality (03:36:57) Cannabis & Sperm Motility, Libido, Pregnancy (03:42:33) Acupuncture, Fertility & Pregnancy (03:49:25) Fertility Supplements: L-Carnitine & Allicin, Coenzyme Q10 (03:56:18) Fertility Supplements: Inositol, Omega 3 Fatty Acids (04:02:50) Supplements for Hormones: Tongkat Ali, Shilajit, Zinc (04:13:02) Fertility & Prescription Medications (04:16:44) Human Reproduction & Fertility (04:20:12) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Disclaimer Title Card Photo Credit: Mike Blabac

Infinite Loops: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Author, CEO of VUDU Marketing and digital nomad Sam McRoberts returns for his second appearance on Infinite Loops. This week, Sam and Jim discuss Sam's latest book ‘The Grand Redesign'. Part science-fiction, part operating manual for upgrading human OS, ‘The Grand Redesign' touches on a number of recurring Infinite Loops themes, and is available for free online (see ‘Important Links' section below). Important Links: The Grand Redesign Sam's Twitter Sam's Substack The Thinker and The Prover Tinkered Thinking's winning entry to our ‘White Mirror' competition Show Notes: Why Sam wrote the book Is the Watcher a reliable narrator? Interfering with complex systems An overview of Social OS Why we need White Mirror The kindness pledge Incentives and the Cobra Effect How do we break the Shannon limit? Jim's movie idea Improving the political and legal system The opportunities of AI Optimising our system for flourishing Finding the hidden geniuses Sam's solutions; reaching the tipping point Sam's hopes for the book MUCH more! Books Mentioned: The Grand Redesign; by Sam McRoberts The Status Game: On Human Life and How to Play It; by Will Storr Prometheus Rising; by Robert Anton Wilson House of Cards: Psychology and Psychotherapy Built on Myth; by Robyn Dawes The Lessons of History: by Will Durant and Ariel Durant Happy: Why More or Less Everything is Absolutely Fine; by Derren Brown The Inevitable: Understanding the 12 Technological Forces That Will Shape Our Future; by Kevin Kelly

Huberman Lab: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- My guest is Rick Rubin, one of the most renowned music producers of all time, known for his work with a wide range of artists, including Run DMC, Public Enemy, Beastie Boys, Red Hot Chili Peppers, JayZ, Adele, Johnny Cash, LL Cool J, Slayer, Neil Young, Kanye West, Tom Petty, and many more. He is also the author of a new book, "The Creative Act: A Way of Being," which explores the creative process and how to access creativity. We discuss topics such as finding inspiration, the role of feelings as guideposts, learning from observing nature, balancing self-doubt and anxiety, and adopting new perspectives to channel the creative process. Rick also shares his thoughts on using deadlines, eliminating distractions, and how our experiences and emotions influence the creative process. Additionally, we discuss his love for professional wrestling. Our conversation can be applied to any activity or profession to access creativity. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Maui Nui: https://mauinuivenison.com/huberman Thesis: https://takethesis.com/huberman WHOOP: https://join.whoop.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Rick Rubin (00:04:08) Maui Nui Venison, Thesis, WHOOP, Momentous (00:08:23) Creativity & Ideas, Cloud Analogy  (00:12:26) Language & Creativity; Kids (00:17:36) Feelings & Creative Ideas (00:22:01) Rules, Choice & Art; Personal Taste & Other's Opinions  (00:30:20) Changing Perspective & Creativity (00:33:55) AG1 (Athletic Greens) (00:35:04) Scientific Knowledge; Opinions & Art (00:41:27) Finishing Projects; The Source & Nature (00:47:40) Perception Filters, Contrast & Novelty (00:58:42) Music & Identity, Evolving Tastes (01:03:03) InsideTracker (01:04:14) Focus, Disengaging & Subconscious; Anxiety  (01:13:22) Collaboration, Art & Rigorous Work (01:18:26) Process & “Cloud”; Perception & Storytelling (01:29:13) Limited Resolution, Considering the Inverse (01:35:38) Wrestling, Energy & Reality; Dopamine  (01:49:43) Wrestling, Style & Performance (01:52:40) Resetting Energy & Nature; Nostalgia (02:01:56) Sleep, Waking Up & Sunlight, Capturing Ideas (02:08:16) Creative Work Phases; Structure & Deadlines (02:15:32) Self-Doubt & Performance (02:19:13) Predictability & Surprise, Authenticity   (02:25:02) Past Experiences, Other's Opinions  (02:29:42) Public Opinion & Science: Light, Acupuncture & Nutrition  (02:39:44) “Look for Clues”, Belief Effects  (02:46:25) Attention, Emotion & Art (02:48:07) Mantra Meditation, Awareness Meditation  (02:57:33) Rick Rubin Questions, Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Disclaimer Title Card Photo Credit: Mike Blabac

All-In with Chamath, Jason, Sacks & Friedberg: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- (0:00) Bestie New Year catch-up! (2:44) Prediction 1: 2023's biggest political winner (17:25) Prediction 2: 2023's biggest political loser (21:57) Prediction 3: 2023's biggest business winner (30:34) Prediction 4: 2023's biggest business loser (42:03) Prediction 5: 2023's biggest business deal (52:41) Prediction 6: 2023's most contrarian belief (1:03:03) Prediction 7: 2023's best-performing asset (1:07:50) Prediction 8: 2023's worst-performing asset (1:14:46) Prediction 9: 2023's most anticipated trend (1:21:40) Prediction 10: 2023's most anticipated media (1:27:07) Breaking news: OpenAI reportedly in talks to sell existing shares at a ~$29B valuation Follow the besties: https://twitter.com/chamath https://linktr.ee/calacanis https://twitter.com/DavidSacks https://twitter.com/friedberg Follow the pod: https://twitter.com/theallinpod https://linktr.ee/allinpodcast Intro Music Credit: https://rb.gy/tppkzl https://twitter.com/yung_spielburg Intro Video Credit: https://twitter.com/TheZachEffect Referenced in the show: https://www.wsj.com/articles/citadel-posts-record-revenues-for-hedge-fund-securities-operations-11672942665 https://www.reuters.com/world/saudi-arabia-gathers-chinas-xi-with-arab-leaders-new-era-ties-2022-12-09/ https://www.nytimes.com/2023/01/03/business/europe-natural-gas-prices.html https://www.nytimes.com/2023/01/04/technology/salesforce-layoffs.html https://www.wsj.com/articles/amazon-to-lay-off-over-17-000-workers-more-than-first-planned-11672874304 https://twitter.com/DavidSacks/status/1598076726671642624 https://www.nytimes.com/2022/12/30/world/asia/xi-putin-china-russia.html https://twitter.com/JenniferJJacobs/status/1611052287954149377 https://www.bloomberg.com/news/articles/2023-01-03/blackstone-s-breit-gets-4-billion-from-university-of-california https://www.nbcnews.com/politics/congress/gop-rebels-block-kevin-mccarthy-defiance-trump-rcna64280 https://www.wsj.com/articles/chatgpt-creator-openai-is-in-talks-for-tender-offer-that-would-value-it-at-29-billion-11672949279

Huberman Lab: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Welcome to a sneak peek of the third Ask Me Anything (AMA) episode, part of Huberman Lab Premium. The Huberman Lab Premium subscription was launched for two main reasons. First, it was launched in order to raise support for the standard Huberman Lab podcast channel — which will continue to come out every Monday at zero-cost. Second, it was launched as a means to raise funds for important scientific research. A significant portion of proceeds from the Huberman Lab Premium subscription will fund human research (not animal models) selected by Dr. Huberman, with a dollar-for-dollar match from the Tiny Foundation. Subscribe to Huberman Lab Premium at https://hubermanlab.com/premium Timestamps (00:00:00) Introduction 00:00:00 Introduction 00:01:27 Adaptogens [Justine Bevilacqua] 00:29:42 Huberman Lab Premium In the full 1.5 hour+ AMA episode, we discuss: Caloric restriction in fertile women Cognitive load limits Potential risks of Bluetooth, Wi-Fi, EMFs Creatine and aging Title Card Photo Credit: Mike Blabac Disclaimer

Artificial Intelligence Podcast: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- MrBeast is a legendary YouTube creator. Please support this podcast by checking out our sponsors: – House of Macadamias: https://houseofmacadamias.com/lex and use code LEX to get 20% off your first order – Eight Sleep: https://www.eightsleep.com/lex to get special savings – BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: MrBeast Main Channel: https://youtube.com/@MrBeast MrBeast Reacts: https://youtube.com/@BeastReacts MrBeast Gaming: https://youtube.com/@MrBeastGaming MrBeast Philanthropy: https://youtube.com/@BeastPhilanthropy MrBeast's TikTok: https://tiktok.com/@mrbeast MrBeast's Twitter: https://twitter.com/MrBeast MrBeast's Instagram: https://instagram.com/mrbeast Feastable's Website: https://feastables.com MrBeast Burger's Website: https://mrbeastburger.com MrBeast's Merch: https://shopmrbeast.com PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT

My First Million: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Episode 405: Shaan Puri (@ShaanVP) and Sam Parr (@TheSamParr) talk about what happens when Shaan leaves the house and meets up with other founders, the power of storytelling, the things you learn when you sell a company and how to hire a researcher. Want to see more MFM? Subscribe to the MFM YouTube channel here. ----- Links: * Alpha Paw * Genius Litter * Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel. * Want more insights like MFM? Check out Shaan's newsletter. ------ Show Notes: (04:20) - Shaan leaves the house and meets cool people (13:15) - When Ramon pretended to be an electrician (18:30) - Power of storytelling (21:25) - Age and perception (28:25) - Frame break (30:10) - Things you learn when you sell a company (46:05) - How to hire a researcher ----- Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more. ----- Additional episodes you might enjoy: • #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits • #209 Gary Vaynerchuk - Why NFTS Are the Future • #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto * #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett • ​​​​#218 - Why You Should Take a Think Week Like Bill Gates • Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More • How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More

A16z Podcast: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- with @robertiger @cdixon @smc90A wide-ranging conversation with Bob Iger on the interplay between technology, content, and distribution; as well as Bob's journey -- and that of various creators! -- especially as the industry evolved from TV and cable to the advent of the internet/ web 1.0 to 2.0 to briefly touching on web3 and other emerging technologies. As well as topics top of mind for all company and community builders: from build vs. buy and the innovator's dilemma, to managing creativity, decentralization, remote work, and much more. Subscribe to web3 with a16z: https://podcasts.apple.com/us/podcast/web3-with-a16z-crypto/id1622312549 Stay Updated: Find us on Twitter: https://twitter.com/a16zFind us on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://twitter.com/stephsmithioPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.

Feel Better, Live More with Dr Rangan Chatterjee ✓ Claim : Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- I believe that conversation matters; that long form nuanced conversation is what we need now more than ever, to make the world a better place. And for me, part of that means exposing ourselves to new ideas, new concepts and new ways of thinking that we may previously have not been exposed to. This week's guest on my Feel Better Live More Podcast is someone who fits that bill perfectly.Dr Zach Bush is a medical doctor and founder of the non-profit Farmer's Footprint, created to find root cause solutions for human and ecological health. His passion for education reaches across many disciplines, including genomics, the immune system, and gut brain health.Zach spent many years as a conventional doctor, specialising in internal medicine, endocrinology and hospice care. Disillusioned with the state of Western medicine, he began taking an integrative approach, studying the body's microbiomes in relation to health, disease and food systems. Today though, Zach describes his life and work as ‘dedicated to the health of humanity and the planet we call home'.In this conversation, Zach makes the case for a revolution in how we understand ourselves, our fellow humans, our healthcare and farming systems – and how we save the world. This episode is a rollercoaster ride through biology, physics, philosophy, economics and environmentalism – all sprinkled with a good dose of inspiration.Zach and I share the view that healthcare needs radical change. It can no longer be about doctors telling patients what's wrong and prescribing drugs and treatments that don't look at the whole person.We discuss how traits of ego, individualism and competition aren't really human at all. And Zach explains how the realisation that all living beings are energetically connected and interdependent is the key to transformation – we cannot thrive as one species if we wipe out others.We also talk about saving our soil and our food systems through regenerative agriculture, and encouraging individuals, farmers and big industry to work together to save the internal and external ecosystems that none of us could live without.Yes, these are big topics. But ultimately, Zach's message is one of hope. He's not afraid to put forward big solutions, and they're all made up of steps each one of us can start taking from today.This is a really special conversation. It's honest, evocative and at times, provocative. I hope you enjoy listening.Support the podcast and enjoy Ad-Free episodes. Try FREE for 7 days on Apple Podcasts https://apple.co/feelbetterlivemore. For other podcast platforms go to https://fblm.supercast.com.Thanks to our sponsors:https://www.athleticgreens.com/livemorehttps://www.vivobarefoot.com/livemorehttps://www.leafyard.com/livemoreShow notes https://drchatterjee.com/298DISCLAIMER: The content in the podcast and on this webpage is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or other qualified health care provider regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website. Hosted on Acast. See acast.com/privacy for more information.

Honestly with Bari Weiss ✓ Claim : Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- When my wife Nellie was pregnant last year, we became obsessed with Economist Emily Oster's book, Expecting Better: Why the Conventional Pregnancy Wisdom Is Wrong–and What You Really Need to Know. Amidst a barrage of conflicting and confusing pregnancy advice, Oster laid out the data on everything we needed to know. Despite what doctors said, sushi, cheese, and the occasional glass of wine were all okay during those nine long months. It gave us the much needed calm we needed during a time of so much uncertainty.  With her two subsequent books Cribsheet and The Family Firm, Oster popularized a new phenomenon that has defined our generation of parents: data-driven parenting. It ditches the long lists of paternalistic rules, and instead examines peer-reviewed evidence and lets parents make their own informed decisions about their kids based on risks and tradeoffs. Nowhere was the Oster mentality more front and center, and more divisive, than during Covid. She argued very early on in the pandemic for less draconian and more nuanced policies. She wrote pieces in the Atlantic like, Schools Aren't Superspreaders and Your Unvaccinated Kids Is Like A Vaccinated Grandma, when those words were considered heresy. And while she made quite a few enemies on the left over the last few years, recently she wrote Let's Declare A Pandemic Amnesty, and earned herself some enemies on the right as well. Today, my wife Nellie Bowles joins me to talk to Oster about why a Harvard-educated economist at Brown University decided to become a parenting guru, how she used her parenting framework to become a leading expert on pandemic policies, and the unwinnable position of… actually following the science. Learn more about your ad choices. Visit megaphone.fm/adchoices

Huberman Lab: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- In this episode, I explain how to design a supplementation protocol to support maximum mental and physical health and performance depending on your specific needs, nutrition, lifestyle and finances. When most people hear about “supplements,” they think they are vitamin supplements, but there are many compounds that are powerful and sold over-the-counter that can enhance our health in performance and that can't be obtained from foods. First, I discuss “foundational” supplements to support overall health, including water and fat-soluble vitamins, minerals, digestive enzymes, adaptogens, and prebiotics/probiotics. Then I explain how to use single-ingredient supplements to enhance specific aspects of your physiology, such as aiding sleep, cognitive enhancement, and focus supporting healthy hormone levels (e.g., testosterone, estrogen and growth hormone, thyroid). Finally, I explain when it makes sense to add supplements to your lifestyle and discuss how best to use supplements, including how to determine dosage, sourcing, continuous schedules and cycling, and how to layer different supplements most effectively. This episode will explain how to design the safest, most biologically effective, cost-effective supplementation protocol to meet your particular goals and support your overall health, including vitality and longevity. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Helix Sleep: https://helixsleep.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Supplements (00:03:38) Hierarchy of Tools/Interventions, Developing a Supplementation Protocol (00:11:51) Momentous, LMNT, Helix Sleep (00:15:38) Role of Supplements, Foundational Supplements, Water/Fat-Soluble Vitamins (00:21:07) Supplement Considerations: Cost, Nutrition & Schedule (00:25:25) Foundational Supplements, Digestive Enzymes, Adaptogens (00:28:04) Gut Microbiome, Probiotics/Prebiotics & Nutrition (00:33:06) Supplements for Gut Microbiome, Brain Fog (00:35:59) InsideTracker (00:36:44) Adaptogens & Broad-Spectrum Foundational Supplements (00:38:35) Core Supplement Questions & Meeting Foundational Needs (00:43:45) Supplements to Support Sleep: Myo-Inositol, Theanine (00:50:52) Supplements for Falling Asleep: Magnesium Threonate/Bisglycinate, Apigenin (00:55:55) Melatonin Caution (00:58:11) Supplement Dependency?, Placebo Effects (01:02:45) AG1 (Athletic Greens) (01:03:53) Nutrition & Behavior for Hormone Health (01:08:59) Hormone Health: Shilajit, Ashwagandha, L-Carnitine, Maca Root  (01:12:48) Growth Hormone: Behaviors, Arginine, Prescriptions  (01:16:04) Testosterone/Estrogen: Fadogia Agrestis; Bloodwork  (01:23:06) Testosterone Supplement: Tongkat Ali, Libido  (01:27:24) Menstrual Cycle, Birth Control & Fertility (01:30:54) Cognitive Enhancement & Focus, Sleep, Stimulants: Caffeine  (01:36:57) Adrenaline & Stimulants: Yohimbine, Rauwolscine (01:38:55) Adjusting Neurotransmitters: Alpha-GPC, L-Tyrosine; Layering Supplements (01:43:58) Cognitive, Mood & Metabolic Support: Omega-3 Fatty Acids (01:47:25) Food-Mimic Supplements, Protein  (01:50:09) Kids, Aging & Supplements (01:55:25) A Rational Supplementation Protocol (01:58:36) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Disclaimer Title Card Photo Credit: Mike Blabac

Masters in Business: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Bloomberg Radio host Barry Ritholtz speaks with the legendary John Mack, former chief executive officer and chairman of the board at Morgan Stanley. His memoir of his life and 34-year tenure at Morgan Stanley — “Up Close and All In: Life Lessons From a Wall Street Warrior” — was published in October. See omnystudio.com/listener for privacy information.

My First Million: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Episode 370: Sam Parr (@TheSamParr) talks to best-selling author, podcaster, bookstore owner, and former marketing director for American Apparel, Ryan Holiday (@RyanHoliday), about how to make money in publishing, creating a masterpiece, and investing in a ghost town. ----- Links: * Ryan Holiday * Trust Me I'm Lying: Confessions of a Media Manipulator * Brass Check * The Painted Porch Bookshop * Vinyl Me, Please * Ghost Town Living * Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel. * Want more insights like MFM? Check out Shaan's newsletter. ------ Show Notes: (03:55) - Does the bestseller list still matter? (05:30) - Breaking down the #s of the publishing industry (29:20) - How big is your team? (35:10) - Who do you admire? (44:40) - The pros and cons of reality distortion fields (50:40) - Ryan's ghost town ----- Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more. ----- Additional episodes you might enjoy: • #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits • #209 Gary Vaynerchuk - Why NFTS Are the Future • #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto * #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett • ​​​​#218 - Why You Should Take a Think Week Like Bill Gates • Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More • How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More

Big Questions with Cal Fussman: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- On the day of Pele's burial, Cal goes to the archives for an interview he did with the man many consider to be the greatest soccer player of all time. This podcast gets to the essence of the Brazilian superstar who connected with almost everyone on the planet. Not only did Pele make everyone smile, he once halted a war. After three years of disconnection due to the pandemic, we need to connect now more than ever. Pele shows us how.

Drive with Dr. Peter Attia: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Kellyann Niotis is a neurologist specializing in risk reduction strategies for the prevention or slowing of neurodegenerative disorders. In this episode, Kellyann provides an overview of the various diseases associated with neurodegeneration, including, but not limited to, Alzheimer's disease, Lewy body dementia, and Parkinson's disease. She goes in-depth on Parkinson's disease, explaining its pathology, role in movement capacity, very early warning signs, and the role of anxiety and sleep. Similarly, she provides an in-depth discussion of Alzheimer's disease, including the latest in screening, genetics, and tools/strategies for prevention. She ties the discussion together by explaining the differences and commonalities among the various diseases of neurodegeneration and the potential causative triggers, and she highlights the importance of early screening, cognitive testing, and taking the proper steps to lowering the risk of disease. We discuss: Kellyann's background, training, and interest in the brain [2:30]; A primer on neurodegeneration: different types, prevalences, interventions, and more [5:30]; Overview of Parkinson's disease and neuromuscular disorders including ALS [16:00]; Parkinson's disease: early signs, diagnosis, genetics, causative triggers, and more [17:30]; Interventions to delay or avoid Parkinson's disease, and the role of sleep and anxiety [31:15]; The challenge of standardizing early interventions for Parkinson's disease without a clear biomarker [39:45]; Alzheimer's disease: pathophysiology and the role of the amyloid and tau proteins [47:45]; Can PET scans be informative for diagnosing Alzheimer's disease? [51:15]; Tau accumulation in the brain, tau scans, serum biomarkers, and possible early detection of Alzheimer's disease pathology [57:00]; Cognitive testing explained [1:03:30]; The challenge of identifying the stage of the disease and why drugs have not shown efficacy [1:14:45]; The association between hearing loss and dementia [1:17:45]; The relationship between oral health and neurodegenerative diseases [1:21:30]; Genetic risk for Alzheimer's disease [1:24:45]; What one's mitochondrial haplotype can reveal about their risk of neurodegenerative disease [1:32:30]; The positive impact of exercise on brain health [1:37:00]; High blood pressure as a risk factor [1:40:00]; Why women are disproportionately affected by Alzheimer's disease [1:44:15]; Final takeaways: the future of understanding neurodegenerative disease and further reducing risk [1:46:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Rich Roll Podcast: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- As 2022 comes to a close and a new year beckons, we are presented with an opportunity to reflect on the past twelve months. Explore new aspirations. And set intentions for the year to come. Allow me to indulge this truth by introducing Part Two of my annual yearbook—an auditory anthology of the year's most compelling conversations. Enjoy the best of the year.Guest List + Full Episode Links:RRP 692: Malcolm GladwellRRP 723: Mel RobbinsRRP 715: Casey NeistatRRP 718: Whitney CummingsRRP 695: Peter Attia, MDRRP 678: Gemma Newman, MDRRP 702: Dr. Gabor MatéRRP 714: Robynne Chutkan, MDRRP 703: Max FisherRRP 660: Sylvia EarleRRP 701: Ken RideoutRRP 694: Colin O'Brady & Jenna BesawRRP 705: Paul Conti, MDRRP 670: Earthling Ed WintersRRP 681: Chip ConleyShow notes + MOREWatch on YouTubeNewsletter Sign-UpToday's Sponsors:Levels: levels.link/RICHROLLNavitas Organics: navitasorganics.com/richrollWhoop: WHOOP.com BetterHelp: BetterHelp.com/richroll.Athletic Greens: athleticgreens.com/richroll Peace + Plants,Rich Hosted on Acast. See acast.com/privacy for more information.