Podcasts about Chan Zuckerberg Initiative

Eric Topol (00:05):Hello, it's Eric Topol from Ground Truths, and I've got some really exciting stuff to talk to you about today. And it's about the announcement for a new Center for pediatric CRISPR Cures. And I'm delight to introduce doctors Jennifer Doudna and Priscilla Chan. And so, first let me say this is amazing to see this thing going forward. It's an outgrowth of a New England Journal paper and monumental report on CRISPR in May. [See the below post for more context]Let me introduce first, Dr. Doudna. Jennifer is the Li Ka Shing Chancellor's Chair and a Professor in the departments of chemistry and of molecular and cell biology at the University of California Berkeley. She's also the subject of this book, one of my favorite books of all time, the Code Breaker. And as you know, the 2020 Nobel Prize laureate for her work in CRISPR-Cas9 genome editing, and she founded the Innovative Genomics Institute (IGI) back 10 years ago. So Jennifer, welcome.Jennifer Doudna (01:08):Thank you, Eric. Great to be here.Eric Topol (01:10):And now Dr. Priscilla Chan, who is the co-founder of the Chan Zuckerberg Initiative (CZI) that also was started back in 2015. So here we are, a decade later, these two leaders. She is a pediatrician having trained at UCSF and is committed to the initiative which has as its mission statement, “to make it possible to cure, prevent, and manage all diseases in this century.” So today we're going to talk about a step closer to that. Welcome, Priscilla.Priscilla Chan (01:44):Thank you. Thanks for having me.Eric Topol (01:46):Alright, so I thought we'd start off by, how did you two get together? Have you known each other for over this past decade since you both got all your things going?Jennifer Doudna (01:56):Yes, we have. We've known each other for a while. And of course, I've admired the progress at the CZI on fundamental science. I was an advisor very early on and I think actually that's how we got to know each other. Right, Priscilla?Priscilla Chan (02:11):Yeah, that's right. We got to know each other then. And we've been crisscrossing paths. And I personally remember the day you won the Nobel Prize. It was in the heart of the pandemic and a lot of celebrations were happening over Zoom. And I grabbed my then 5-year-old and got onto the UCSF celebration and I was like, look, this is happening. And it was really cool for me and for my daughter.Eric Topol (02:46):Well, it's pretty remarkable convergence leading up to today's announcement, but I know Priscilla, that you've been active in this rare disease space, you've had at CZI a Rare As One Project. Maybe you could tell us a bit about that.Priscilla Chan (03:01):Yeah, so at CZI, we work on basic science research, and I think that often surprises people because they know that I'm a pediatrician. And so, they often think, oh, you must work in healthcare or healthcare delivery. And we've actually chosen very intentionally to work in basic science research. In part because my training as a pediatrician at UCSF. As you both know, UCSF is a tertiary coronary care center where we see very unusual and rare cases of pediatric presentations. And it was there where I learned how little we knew about rare diseases and diseases in general and how powerful patients were. And that research was the pipeline for hope and for new discoveries for these families that often otherwise don't have very much access to treatments or cures. They have a PDF that maybe describes what their child has. And so, I decided to invest in basic science through CZI, but always saw the power of bringing rare disease patient cohorts. One, because if you've ever met a parent of a child with rare disease, they are a force to be reckoned with. Two, they can make research so much better due to their insights as patients and patient advocates. And I think they close the distance between basic science and impact in patients. And so, we've been working on that since 2019 and has been a passion of ours.Eric Topol (04:40):Wow, that's great. Now Jennifer, this IGI that you founded a decade ago, it's doing all kinds of things that are even well beyond rare diseases. We recently spoke, I know on Ground Truths about things as diverse as editing the gut microbiome in asthma and potentially someday Alzheimer's. But here you were very much involved at IGI with the baby KJ Muldoon. Maybe you could take us through this because this is such an extraordinary advance in the whole CRISPR Cures story.Jennifer Doudna (05:18):Yes, Eric. It's a very exciting story and we're very, very proud of the teamwork that went into making it possible to cure baby KJ of his very rare disease. And in brief, the story began back in August of last year when he was born with a metabolic disorder that prevented him from digesting protein, it's called a urea cycle disorder and rare, but extremely severe. And to the point where he was in the ICU and facing a very, very difficult prognosis. And so, fortunately his clinical team at Children's Hospital of Philadelphia (CHOP) reached out to Fyodor Urnov, who is the Director of Translational Medicine at the IGI here in the Bay Area. They teamed up and realized that they could quickly diagnose that child because we had an IRB approved here at the IGI that allowed us to collect patient samples and do diagnosis. So that was done.Jennifer Doudna (06:26):We created an off-the-shelf CRISPR therapy that would be targeted to the exact mutation that caused that young boy's disease. And then we worked with the FDA in Washington to make sure that we could very safely proceed with testing of that therapy initially in the lab and then ultimately in two different animal models. And then we opened a clinical trial that allowed that boy to be enrolled with, of course his parents' approval and for him to be dosed and the result was spectacular. And in fact, he was released from the hospital recently as a happy, healthy child, gaining lots of weight and looking very chunky. So it's really exciting.Eric Topol (07:16):It's so amazing. I don't think people necessarily grasp this. This timeline [see above] that we'll post with this is just mind boggling how you could, as you said Jennifer, in about six months to go from the birth and sequencing through cell specific cultures with the genome mutations through multiple experimental models with non-human primates even, looking at off-target effects, through the multiple FDA reviews and then dosing, cumulatively three dosing to save this baby's life. It really just amazing. Now that is a template. And before we go to this new Center, I just wanted to also mention not just the timeline of compression, which is unimaginable and the partnership that you've had at IGI with I guess Danaher to help manufacture, which is just another part of the story. But also the fact that you're not just even with CRISPR 1.0 as being used in approvals previously for sickle cell and β-thalassemia, but now we're talking about base editing in vivo in the body using mRNA delivery. So maybe you could comment on that, Jennifer.Jennifer Doudna (08:38):Yeah, very good point. So yeah, we used a version of CRISPR that was created by David Liu at the Broad Institute and published and available. And so, it was possible to create that, again, targeted to the exact mutation that caused baby KJ's disease. And fortunately, there was also an off-the-shelf way to deliver it because we had access to lipid nanoparticles that were developed for other purposes including vaccinations. And the type of disease that KJ suffered from is one that is treatable by editing cells in the liver, which is where the lipid nanoparticle naturally goes. So there were definitely some serendipity here, but it was amazing how all of these pieces were available. We just had to pull them together to create this therapy.Eric Topol (09:30):Yeah, no, it is amazing. So that I think is a great substrate for starting a new Center. And so, maybe back to you Priscilla, as to what your vision was when working with Jennifer and IGI to go through with this.Priscilla Chan (09:45):I think the thing that's incredibly exciting, you mentioned that at CZI our mission is to cure, prevent, and manage all disease. And when we talked about this 10 years ago, it felt like this far off idea, but every day it seems closer and closer. And I think the part that's super exciting about this is the direct connection between the basic science that's happening in CRISPR and the molecular and down to the nucleotide understanding of these mutations and the ability to correct them. And I think many of us, our imaginations have included this possibility, but it's very exciting that it has happened with baby KJ and CHOP. And we need to be able to do the work to understand how we can treat more patients this way, how to understand the obstacles, unblock them, streamline the process, bring down the cost, so that we better understand this pathway for treatment, as well as to increasingly democratize access to this type of platform. And so, our hope is to be able to do that. Take the work and inspiration that IGI and the team at CHOP have done and continue to push forward and to look at more cases, look at more organ systems. We're going to be looking in addition to the liver, at the bone marrow and the immune system.Priscilla Chan (11:17):And to be able to really work through more of the steps so that we can bring this to more families and patients.Eric Topol (11:30):Yeah, well it's pretty remarkable because here you have incurable ultra-rare diseases. If you can help these babies, just think of what this could do in a much broader context. I mean there a lot of common diseases have their roots with some of these very rare ones. So how do you see going forward, Jennifer, as to where you UC Berkeley, Gladstone, UCSF. I'm envious of you all up there in Northern California I have to say, will pull this off. How will you get the first similar case to KJ Muldoon going forward?Jennifer Doudna (12:13):Right. Well, IGI is a joint institute, as you probably know, Eric. So we were founded 10 years ago as a joint institute between UC Berkeley and UCSF. And now we have a third campus partner, UC Davis and we have the Gladstone Institute. So we've got an extraordinary group of clinicians and researchers that are coming together for this project and the Center to make it a success. We are building a clinical team at UCSF. We have several extraordinary leaders including Jennifer Puck and Chris Dvorak, and they are both going to be involved in identifying patients that could be enrolled in this program based on their diagnosis. And we will have a clinical advisory group that will help with that as well. So we'll be vetting patients probably right after we announce this, we're going to be looking to start enrolling people who might need this type of help.Eric Topol (13:18):Do you think it's possible to go any faster right now than the six months that it took for KJ?Jennifer Doudna (13:26):I think it could be. And here's the reason. There's a very interesting possibility that because of the type of technology that we're talking about with CRISPR, which fundamentally, and you and I have talked about this previously on your other podcast. But we've talked about the fact that it's a programmable technology and that means that we can change one aspect of it, one piece of it, which is a piece of a molecule called RNA that's able to direct CRISPR to the right sequence where we want to do editing and not change anything else about it. The protein, the CRISPR protein stays the same, the delivery vehicle stays the same, everything else stays the same. And so, we're working right now with FDA to get a platform designation for CRISPR that might allow streamlining of the testing process in some cases. So it'll obviously come down to the details of the disease, but we're hopeful that in the end it will be possible. And Priscilla and I have talked about this too, that as AI continues to advance and we get more and more information about rare diseases, we'll be able to predict accurately the effects of editing. And so, in some cases in the future it may be possible to streamline the testing process even further safely.Eric Topol (14:51):And I also would note, as you both know, well this administration is really keen on genome editing and they've had a joint announcement regarding their support. And in my discussions with the FDA commissioner, this is something they are very excited about. So the timing of the new Center for pediatric CRISPR Cures is aligned with the current administration, which is good to see. It's not always the case. Now going back, Priscilla, to your point that not just for the liver because delivery has been an issue of course, and we're going to try to get after a lot of these really rare diseases, it's going to go beyond there. So this is also an exciting new dimension of the Center, as you said, to go after the bone marrow for hematopoietic cells, perhaps other organs as well.Priscilla Chan (15:42):I mean what the expertise and feasibility, the immune system is going to be the next target. Jennifer Puck has been a pioneer in this work. She's the one who designed the newborn screen that will be the tool that picks up these patients as they are born. And I think the thing that's tremendous is the immune system, first of all is active in many, many diseases, not just these cases of children born with partial or absence of immune systems. And the course right now that these babies are left with is complete isolation and then a very long and arduous course of a bone marrow transplant with high morbidity and mortality. And even if after the transplant you have complications like graft versus host and immunosuppression. And so, the idea of being able to very specifically and with less the conditioning and morbidity and mortality of the treatment, being able to address this is incredible. And the implications for other diseases like blood cancers or other hematopoietic diseases, that's incredible. And that actually has an incredibly broad base of patients that can benefit from the learnings from these babies with severe combined immunodeficiencies.Eric Topol (17:10):Yeah, I think that goes back to a point earlier maybe to amplify in that previous CRISPR generation, it required outside the body work and it was extremely laborious and time consuming and obviously added much more to the expense because of hospitalization time. This is different. This is basically doing this inside the affected patient's body. And that is one of the biggest reasons why this is a big step forward and why we're so fortunate that your Center is moving forward. Maybe before we wrap up, you might want to comment, Jennifer on how you were able to bring in to build this platform, the manufacturing arm of it, because that seems to be yet another dimension that's helpful.Jennifer Doudna (18:01):Indeed, yes. And we were again fortunate with timing because you mentioned briefly that the IGI had set up a program with the Danaher Corporation back in January of last year. We call it our Beacon project. And it's focused on rare disease. And it's a really interesting kind of a unique partnership because Danaher is a manufacturing conglomerate. So they have companies that make molecules, they make proteins, they make RNA molecules, they make delivery molecules. And so, they were excited to be involved with us because they want to be a provider of these types of therapies in the future. And they can see the future of CRISPR is very exciting. It's expanding, growing area. And so, that agreement was in place already when the baby KJ case came to our attention. And so, what we're hoping to do with Danaher is again, work with them and their scientists to continue to ask, how can we reduce the cost of these therapies by reducing the cost of the molecules that are necessary, how to make them efficiently. We already, it's very interesting, Fyodor Urnov has toured their plant in North Dakota recently, and he found in talking to their engineers, there are a number of things that we can already see will be possible to do that are going to make the process of manufacturing these molecules faster and cheaper by a lot.Eric Topol (19:28):Wow.Jennifer Doudna (19:28):So it's a win-win for everybody. And so, we're really excited to do that in the context of this new Center.Eric Topol (19:36):Oh, that's phenomenal because some of these disorders you don't have that much time to work with before they could be brain or organ or vital tissue damage. So that's great to hear that. What you built here is the significance of it can't be under emphasized, I'll say because we have this May report of baby KJ, which could have been a one-off and it could have been years before we saw another cure of an ultra-rare disorder. And what you're doing here is insurance against that. You're going to have many more cracks at this. And I think this is the excitement about having a new dedicated Center. So just in closing, maybe some remarks from you Priscilla.Priscilla Chan (20:24):I just want to emphasize one point that's really exciting as we talk about these ultra-rare cases that they're often like one in a million. All these learnings actually help maximize the impact of lots of research across the sector that impacts actually everyone's health. And so, our learnings here from these patients that have very significant presentations that really can stand to benefit from any treatment is hopefully paving the way for many, many more of us to be able to live healthier, higher quality lives through basic science.Eric Topol (21:13):And over to you, Jennifer.Jennifer Doudna (21:15):Couldn't agree more. It's a really interesting moment. I think what we hope we are, is we're at sort of an inflection point where, as I mentioned earlier, all the pieces are in place to do this kind of therapeutic and we just need a team that will focus on doing it and pulling it together. And also learning from that process so that as Priscilla just said, we are ultimately able to use the same strategy for other diseases and potentially for diseases that affect lots of people. So it's exciting.Eric Topol (21:46):For sure. Now, if I could just sum up, this is now a decade past the origination of your work of CRISPR and how already at the first decade culminated in sickle cell disease treatment and β-thalassemia. Now we're into the second decade of CRISPR. And look what we've seen, something that was unimaginable until it actually happened and was reported just a little over a month ago. Now going back to Priscilla's point, we're talking about thousands of different rare Mendelian genomic disorders, thousands of them. And if you add them all up of rare diseases, we're talking about hundreds of millions of people affected around the world. So this is a foray into something much bigger, no less the fact that some of these rare mutations are shared by common diseases and approaches. So this really big stuff, congratulations to both of you and your organizations, the Innovative Genomics Institute and the Chan Zuckerberg Initiative for taking this on. We'll be following it with very deep interest, thank you.****************************************************Thanks for listening, reading and subscribing to Ground Truths.If you found this interesting PLEASE share it!That makes the work involved in putting these together especially worthwhile.Thanks to Scripps Research, and my producer, Jessica Nguyen, and Sinjun Balabanoff for video/audio support.All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don't hesitate to post comments and give me feedback. Let me know topics that you would like to see covered.Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. Get full access to Ground Truths at erictopol.substack.com/subscribe

On this week's Tech Nation, Moira speaks with Pulitzer-Prize winning author, Ed Humes, talks about his book, “Total Garbage… How We Can Fix Our Waste and Heal Our World.” Then, Dr. Steve Quake, Head of Science at the Chan Zuckerberg Initiative, tells us about their ambitious goal to address all human diseases within the next century.

What happens when a philanthropist shows up differently? In this episode, Maya Ghosh Bichara joins host Lars Peter Nissen to reflect on what it means to fund, partner, and build trust with integrity.Maya isn't running a billion-dollar foundation - she gives small but catalytic grants, drawing on her experience from the Chan Zuckerberg Initiative to reimagine what money can do.They explore trust-based philanthropy, the need for humility, and how to move beyond extractive funding models. What would it take to let go of control, trust leaders on the ground, and how could we try to decolonize funding flows?Mayas biggest advice for change is to start implementing it yourself. This episode is a must for anyone curious about what a new generation of philanthropy might look like.

On this episode, Tania Simoncelli (Vice President, Translational Impact and Engagement, Chan Zuckerberg Initiative) and Nasha Fitter (Co-founder & CBO, Citizen Health and Co-founder & CEO, FOXG1 Research Foundation) join forces to discuss how rare disease patient advocacy has transformed over time and how the biopharmaceutical industry should adapt to better meet the needs of today's patients. They dive deeper into the evolution of rare disease patient advocacy groups, why industry must move beyond the hyperfocus on “blockbuster drugs” to make progress in rare disease research, and how advancements in rare disease treatments can benefit the clinical research ecosystem for all.

In our explosive new episode of, The Ultimate Assist, John Stockton and Ken Ruettgers welcome back Stefanie Stark for a jaw-dropping continuation of her revelations about the nonprofit sector. Building on her first appearance, Stefanie pulls back the curtain on how “Big Philanthropy” — from the UN to the CDC Foundation to private players like the Gates Foundation and even Zuckerberg's Chan-Zuckerberg Initiative — uses nonprofits to launder money, push government agendas, and silence dissent.She details how tax dollars intended for charity often fund covert programs, vaccine initiatives, and censorship efforts disguised as humanitarian aid. Stefanie also breaks down the political fallout from Trump's crackdown on USAID funding, revealing an underground resistance forming within nonprofits to circumvent new reforms.This is the episode the nonprofit sector doesn't want you to hear.Listen as Stefanie Stark sounds the alarm on how “charity” has become one of the biggest engines for hidden agendas in America—and why reform has never been more urgent.

Today, approximately 10,000 rare diseases collectively affect as many as 400 million people around the world, and women leaders have long been at the forefront of bringing awareness to these diseases and driving change. Katie Couric moderates a panel that includes Tania Simoncelli of Chan Zuckerberg Initiative, whose “Rare as One” campaign gives to rare disease researchers and support groups, Tara Zier who founded the Stiff Person Syndrome Research Foundation, Susan Dando of the Smith-Kingsmore Syndrome Foundation, and Dr. Christina Miyake, a researcher studying TANGO2 deficiency disorder. This panel will explore the resilience, determination, and ingenuity required to address the unique challenges in rare disease advocacy and research. Panelists will share their experiences in breaking barriers, leading patient-centered initiatives, and building collaborations that move the needle toward treatments and cures. #SponsoredbyCZISee omnystudio.com/listener for privacy information.

Send us a textDr. Nina Sabarre, founder and CEO of Intention to Impact, takes us deep into the urgent challenges philanthropy faces in our current political climate. With federal programs under attack and DEI initiatives being dismantled, foundations stand at a pivotal crossroads – will they retreat or boldly step forward?Dr. Sabarre reveals how foundations aren't responding uniformly to these challenges. While some double down on equity commitments, others conduct closed-door strategy sessions, fearing repercussions from a hostile administration. This tension highlights a fundamental question: How can philanthropy effectively support communities when macro-level systems are shifting dramatically?The conversation explores how traditional philanthropic models might be fundamentally misaligned. Most foundations distribute just 5% of their assets, while the remaining 95% remains invested in markets that often perpetuate the very problems their grants aim to solve. Dr. Sabarre unpacks impact investing as a powerful alternative, enabling foundations to generate both financial returns and positive social outcomes while deploying a greater portion of their capital toward their mission.Perhaps most compelling is Nina's analysis of systems change strategies. Using the "Waters of Systems Change" framework, she demonstrates how conservative movements have masterfully funded long-term influence through strategic investments in media, churches, and educational institutions. At the same time, progressive philanthropy often focuses on immediate community needs rather than building lasting power.For those working in evaluation, nonprofit leadership, or community organizing, Dr. Sabarre offers practical wisdom for navigating these turbulent waters – from maintaining commitment to community-centered approaches despite funding pressures to building stronger coalitions and drawing lessons from successful social movements of the past.Subscribe to Community Possibilities wherever you get your podcasts to continue exploring what's possible when people come together to create lasting change in our communities. Be sure to connect with Nina and sign up for Intention 2 Impact's newsletter.BioNina is passionate about gender, racial, and social equity, and using #evalpreneurship to dismantle the status quo. She has consulted for a wide variety of cross-sector institutions ranging from Earthjustice, WK Kellogg Foundation, The California Endowment, TED's Audacious Project, Elevate Prize Foundation, Walton Family Foundation, Colorado Health Foundation, Chan Zuckerberg Initiative, Omidyar Network, and USAID to name a few. Her work focuses on equitable evaluation for strategic grantmaking and syLike what you heard? Please like and share wherever you get your podcasts! Connect with Ann: Community Evaluation Solutions How Ann can help: · Support the evaluation capacity of your coalition or community-based organization. · Help you create a strategic plan that doesn't stress you and your group out, doesn't take all year to design, and is actionable. · Engage your group in equitable discussions about difficult conversations. · Facilitate a workshop to plan for action and get your group moving. · Create a workshop that energizes and excites your group for action. · Speak at your conference or event. Have a question or want to know more? Book a call with Ann .Be sure and check out our updated resource page! Let us know what was helpful. Music by Zach Price: Zachpricet@gmail.com

Guest Neil Chue Hong Panelists Richard Littauer | Justin Dorfman Show Notes In this episode of Sustain, hosts Richard Littauer and Justin Dorfman talk with Neil Chue Hong, Director of the Software Sustainability Institute (SSI). They discuss the SSI's mission to sustain software used in research, the institute's history and funding, the role of research software engineers, and the newly launched Research Software Maintenance Fund (RSMF) with £4.8 million dedicated to supporting research software. Neil shares insights into the collaboration, training initiatives, and policy work done by the SSI to promote sustainability in software development. The episode also touches on the impact of large funding initiatives like those from the Chan Zuckerberg Initiative and the evolving role of software development in the age of large language models (LLMs). Hit the download button now! [00:01:44] Neil explains SSI's mission and purpose. [00:02:27] Richard inquires about SSI's funding model and how long SSI has existed. Neil explains SSI is a government funded collaboration via UK Research and Innovation (UKRI), and it was founded in 2010 and is funded through 2028. [00:05:03] Richard highlights SSI's impact and Neil discusses how SSI helped establish “Research Software Engineer (RSE)' as a recognized role. [00:08:20] SSI's annual Collaborations Workshop (May 13-15 in Stirling, UK) is mentioned, and Neil recalls a pivotal collaboration with Greg Wilson (Software Carpentry), which expanded training programs. [00:11:16] Neil explains that the SSI has evolved from consultancy to training, community initiatives, and policy advocacy to scale its impact and ensure long-term sustainability in research software. [00:13:57] Richard introduces SSI's new £4.8M Research Software Maintenance Fund (RSMF). Neil explains it supports maintaining existing research software and it's funded by the UK's Digital Research Infrastructure Programme (UKRI). [00:16:54] A question comes up about the geopolitical impact of this funding and Neil states the UK is maintaining leadership in research software sustainability, not just focusing on national capability. [00:20:54] Neil defines research software products being targeted by the RSMF as software used beyond its original development team. [00:22:54] Richard asks if £4.8M is a significant investment and Neil explains this is comparable to past UK research software grants.. [00:25:10] Neil acknowledges Chan Zuckerberg Initiative (CZI) for improving funding models for research software. [00:29:45] Justin asks how LLMs are changing research software engineering. Neil compares LLMs' impact on software development to smartphones revolutionizing photography. [00:34:05] Find out where you can connect with UKRI, SSI, and with Neil on the web. Quotes [00:02:07] “We've got this motto: Better Software, Better Research.” [00:29:03] “You can define what is clearly sci-fi, you can define what is clearly research software, but making an arbitrary cut-off point is really hard.” Spotlight [00:35:13] Justin's spotlight is ghostty. [00:35:40] Richard's spotlight is Olympus Tough cameras. [00:36:34] Neil's spotlight is The Carpentries and Cinema For All. Links SustainOSS (https://sustainoss.org/) podcast@sustainoss.org (mailto:podcast@sustainoss.org) richard@sustainoss.org (mailto:richard@sustainoss.org) SustainOSS Discourse (https://discourse.sustainoss.org/) SustainOSS Mastodon (https://mastodon.social/tags/sustainoss) Open Collective-SustainOSS (Contribute) (https://opencollective.com/sustainoss) Richard Littauer Socials (https://www.burntfen.com/2023-05-30/socials) Justin Dorfman X (https://twitter.com/jdorfman?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor) Neil Chue Hong LinkedIn (https://www.linkedin.com/in/neilchuehong/) Software Sustainability Institute (SSI) (https://www.software.ac.uk/) Save the date for Collaborations Workshop 2025 (CW25)-SSI (https://www.software.ac.uk/news/save-date-collaborations-workshop-2025-cw25) UKRI awards the Software Sustainability Institute £4.8m to strengthen research software maintenance in the UK (SSI) (https://www.software.ac.uk/news/ukri-awards-software-sustainability-institute-ps48m-strengthen-research-software-maintenance) Digital Research Infrastructure Programme (UKRI) (https://www.ukri.org/what-we-do/creating-world-class-research-and-innovation-infrastructure/digital-research-infrastructure/) Sustain Podcast- Episode 43: Investing in Open Infrastructure with Kaitlin Thaney (https://podcast.sustainoss.org/guests/kaitlin-thaney) Sustain Podcast- Episode 230: Kari L. Jordan on The Carpentries (https://podcast.sustainoss.org/guests/kari-jordan) Sustain Podcast- Episode 235: The State of Open Infrastructure 2024, from IOI with Emmy Tsang (https://podcast.sustainoss.org/guests/emmy-tsang) Open Source in Academia Map (https://sustainoss.org/academic-map/) ghostty (https://ghostty.org/) Olympus Tough camera (https://explore.omsystem.com/us/en/tough) The Carpentries (https://carpentries.org/) Cinema For All (https://cinemaforall.org.uk/) Credits Produced by Richard Littauer (https://www.burntfen.com/) Edited by Paul M. Bahr at Peachtree Sound (https://www.peachtreesound.com/) Show notes by DeAnn Bahr Peachtree Sound (https://www.peachtreesound.com/) Special Guest: Neil Chue Hong.

Nonprofit NewsFeed Podcast: Trump Administration Impact & Philanthropy's Response Episode Summary In this episode of the Nonprofit News Feed Podcast, host Nick Azulay is joined by Whole Whale COO and President Megan Anhalt to discuss the new Trump administration's impact on the social impact sector and philanthropy. The conversation covers the federal funding freeze affecting numerous nonprofit organizations, particularly highlighting the stop work order affecting unaccompanied minors in immigration proceedings and the devastating fallout from USAID funding cuts. As organizations struggle to fill these gaps, they examine the critical role philanthropy must play during this crisis. The hosts then do a deep dive into the Chan Zuckerberg Initiative's (CZI) recent decision to end its social advocacy funding, including work on immigration reform and racial equity, and end its DEI efforts—a move that came shortly after Meta (formerly Facebook) made similar cuts. They analyze this as a case study of how even the most well-resourced philanthropic entities are yielding to political pressure.

Nonprofit NewsFeed Podcast: Trump Administration Impact & Philanthropy's Response Episode Summary In this episode of the Nonprofit News Feed Podcast, host Nick Azulay is joined by Whole Whale COO and President Megan Anhalt to discuss the new Trump administration's impact on the social impact sector and philanthropy. The conversation covers the federal funding freeze affecting numerous nonprofit organizations, particularly highlighting the stop work order affecting unaccompanied minors in immigration proceedings and the devastating fallout from USAID funding cuts. As organizations struggle to fill these gaps, they examine the critical role philanthropy must play during this crisis. The hosts then do a deep dive into the Chan Zuckerberg Initiative's (CZI) recent decision to end its social advocacy funding, including work on immigration reform and racial equity, and end its DEI efforts—a move that came shortly after Meta (formerly Facebook) made similar cuts. They analyze this as a case study of how even the most well-resourced philanthropic entities are yielding to political pressure.

On this episode, John Bailey, who advises on AI and innovation at a number of organizations, including the American Enterprise Institute, Chan Zuckerberg Initiative, and more, joins Michael and Diane. They discuss AI's potential to democratize access to expertise, weigh the costs and benefits of its efficiency-boosting applications, and consider how it will change skillsContinue reading "Democratizing Access to Expertise: AI in Education"

In November, Citizen Health unveiled itself with $14.5 million in funding and a partnership with the Chan Zuckerberg Initiative. A reinvention of what began life as Ciitizen, Citizen Health takes a sharp focus on rare disease, a departure from its precursor, which was initially envisioned as a tool for cancer patients to gather all of their health data in a single place. We spoke to Citizen Health Co-Founders Farid Vij and Nasha Fitter about the evolution of Citizen Health, what it will enable, and how it is helping shift power towards patients and their caregivers in the pursuit of new therapies.

Nathan discusses groundbreaking AI and biology research with Stanford Professor James Zou from the Chan Zuckerberg Initiative. In this episode of The Cognitive Revolution, we explore two remarkable papers: the virtual lab framework that created novel COVID treatments with minimal human oversight, and InterPLM's discovery of new protein motifs through mechanistic interpretability. Join us for an fascinating discussion about how AI is revolutionizing biological research and drug discovery. Got questions about AI? Submit them for our upcoming AMA episode + take our quick listener survey to help us serve you better - https://docs.google.com/forms/d/e/1FAIpQLSefHvs1-1g5xeqM7wSirQkzTtK-1fgW_OjyHPH9DvmbVAjEzA/viewform SPONSORS: SelectQuote: Finding the right life insurance shouldn't be another task you put off. SelectQuote compares top-rated policies to get you the best coverage at the right price. Even in our AI-driven world, protecting your family's future remains essential. Get your personalized quote at https://selectquote.com/cognitive Oracle Cloud Infrastructure (OCI): Oracle's next-generation cloud platform delivers blazing-fast AI and ML performance with 50% less for compute and 80% less for outbound networking compared to other cloud providers13. OCI powers industry leaders with secure infrastructure and application development capabilities. New U.S. customers can get their cloud bill cut in half by switching to OCI before December 31, 2024 at https://oracle.com/cognitive 80,000 Hours: 80,000 Hours is dedicated to helping you find a fulfilling career that makes a difference. With nearly a decade of research, they offer in-depth material on AI risks, AI policy, and AI safety research. Explore their articles, career reviews, and a podcast featuring experts like Anthropic CEO Dario. Everything is free, including their Career Guide. Visit https://80000hours.org/cognitiverevolution to start making a meaningful impact today. GiveWell : GiveWell has spent over 17 years researching global health and philanthropy to identify the highest-impact giving opportunities. Over 125,000 donors have contributed more than $2 billion, saving over 200,000 lives through evidence-backed recommendations. First-time donors can have their contributions matched up to $100 before year-end. Visit https://GiveWell.org select podcast, and enter Cognitive Revolution at checkout to make a difference today. CHAPTERS: CHAPTERS: (00:00:00) Teaser (00:00:35) About the Episode (00:04:30) Virtual Lab (00:08:09) AI Designs Nanobodies (00:14:43) Novel AI Pipeline (00:20:31) Human-AI Interaction (Part 1) (00:20:33) Sponsors: SelectQuote | Oracle Cloud Infrastructure (OCI) (00:23:22) Human-AI Interaction (Part 2) (00:32:31) Sponsors: 80,000 Hours | GiveWell (00:35:10) Project Cost & Time (00:41:04) Future of AI in Bio (00:45:46) InterPLM: Intro (00:50:30) AI Found New Concepts (00:55:02) Discovering New Motifs (00:57:14) Limitations & Future (01:01:32) Outro SOCIAL LINKS: Website: https://www.cognitiverevolution.ai Twitter (Podcast): https://x.com/cogrev_podcast Twitter (Nathan): https://x.com/labenz LinkedIn: https://www.linkedin.com/in/nathanlabenz/ Youtube: https://www.youtube.com/@CognitiveRevolutionPodcast

In this episode of the Micro Binfie Podcast, host Andrew Page catches up with Torsten Seemann at the 10th Microbial Bioinformatics Hackathon in Bethesda, Maryland. They discuss the rapid evolution of bioinformatics, the challenges faced by labs worldwide, and the explosion of tools post-COVID. Torsten shares insights into his work at Melbourne's Microbiological Diagnostic Unit (MDU), the development of platforms like OzTracker for bacterial genomics, and how his lab plays a national and international role in data sharing. The conversation dives into the future of the widely-used variant calling tool Snippy, as Torsten reveals exciting updates funded by the Chan Zuckerberg Initiative, including nanopore read support and the ability to process pre-assembled genomes. They also explore the importance of maintaining open-source bioinformatics tools to prevent them from becoming obsolete. Tune in for an in-depth discussion on the state of genomics, software development, and the challenges and rewards of open-source collaboration.

What would it take to create an Artificial Ovary?Meet Ariella Shikanov, professor of biomedical engineering at the University of Michigan. Earlier this year, her team at Shikanov Lab made history when they created a new Map of the Ovary.With the support of the Chan Zuckerberg Initiative, Ariella's team mapped gene expression in various regions of the ovary, marking a major milestone in our understanding of reproductive biology.Enjoy!Want to become a MOTHER-sponsor and create some magic together? Reach out to us: https://shorturl.at/0RHLM(00:00) Intro(03:00) How ovaries work: eggs, hormones, and follicles explained(06:10) Puberty and how the brain controls your ovaries(07:30) How your ovaries talk to other organs(09:00) Key findings from Map of The Ovary research(12:00) Oncofertility: preserving fertility during cancer treatment(15:30) The challenge and hope of freezing ovarian tissue(17:50) Delaying menopause: new approaches to keep ovaries functioning longer(21:00) The future of artificial ovaries and extending hormone production(24:00) How the immune system affects ovarian health, PCOS, and endometriosis(28:00) Women's immune health and its role in reproduction(31:00) Ethical questions in ovarian research(35:00) How delaying menopause could improve quality of life(37:50) How Ariella's work is shaping the future of women's healthLinks:Ariella's X Profile - https://x.com/ariellashikanovShikanov Lab at University of Michigan - Research overview, publications, and projects related to preserving ovarian function and artificial ovary development.https://www.shikanov.bme.umich.eduMap of the Human Ovary - Spatial Atlas Research - A detailed explanation of the map created by Shikanov Lab, including its implications for fertility research.https://news.engin.umich.edu/articles/spatial-atlas-of-the-human-ovaryHuman Cell Atlas: Ovarian Map - A cellular atlas of the human ovary using spatial transcriptomics and single-cell sequencing data.https://explore.data.humancellatlas.org/projects/f598aee0-d269-4036-90e9-d6d5b1c84429 Hosted on Acast. See acast.com/privacy for more information.

The team began following Chrastil shortly before she became pregnant through in vitro fertilization. During the pregnancy and for two years after she gave birth, they continued doing MRI brain scans and blood tests to see how her brain changed. During this time, Chrastil's sex hormones, like estrogen, increased and decreased. Some of the changes continued past pregnancy. 在克拉斯蒂尔通过体外受精怀孕前不久，研究小组开始追踪她。在她怀孕期间和产后两年内，他们继续进行核磁共振脑部扫描和血液测试，以了解她的大脑如何变化。在此期间，克里斯提尔的性激素（如雌激素）增加或减少。一些变化在怀孕后持续存在。 Emily Jacobs is with the University of California, Santa Barbara and was also a co-writer of the study. Jacobs said earlier studies had taken scans of the brain before and after pregnancy. But she said, none had shown changes in the brain as they were taking place. 艾米丽·雅各布斯 (Emily Jacobs) 来自加州大学圣巴巴拉分校，也是该研究的合著者。雅各布斯说，早期的研究已经在怀孕前后对大脑进行了扫描。但她说，没有一个实验显示出大脑在发生变化时发生的变化。 Unlike past studies, this one centered on many inner areas of the brain as well as the cerebral cortex, the outermost area, said Joseph Lonstein. He is a professor of neuroscience and psychology at Michigan State University and was not involved in the research. 约瑟夫·朗斯坦说，与过去的研究不同，这项研究集中于大脑的许多内部区域以及大脑皮层（最外层的区域）。他是密歇根州立大学神经科学和心理学教授，并未参与这项研究。 Lonstein said it is “a good first step to understanding much more about whole-brain changes that could be possible in a woman across pregnancy and postpartum.” 朗斯坦说，这是“更好地了解女性在怀孕和产后可能发生的全脑变化的良好第一步。” Research in animals has linked some brain changes with qualities that could help the animal care for an infant. The new study does not deal with what the changes mean in terms of human behavior. 对动物的研究发现，一些大脑变化与有助于动物照顾婴儿的品质有关。这项新研究并未涉及这些变化对人类行为意味着什么。 However, Lonstein said that it does describe changes in brain areas involved in social cognition, or thinking. This is how people act with others -- for example, how they understand their thoughts and feelings. 然而，朗斯坦表示，它确实描述了涉及社会认知或思维的大脑区域的变化。这就是人们与他人相处的方式——例如，他们如何理解自己的想法和感受。 The researchers have partners in Spain, and they are developing what they call the Maternal Brain Project. The Ann S. Bowers Women's Brain Health Initiative and the Chan Zuckerberg Initiative support the project. The researchers say they hope scientists can use findings from more than one woman to predict problems such as postpartum depression. 研究人员在西班牙有合作伙伴，他们正在开发所谓的母脑项目。安·S·鲍尔斯 (Ann S. Bowers) 女性大脑健康倡议和陈·扎克伯格倡议 (Chan Zuckerberg Initiative) 支持该项目。研究人员表示，他们希望科学家能够利用不止一名女性的研究结果来预测产后抑郁症等问题。 “There is so much about the neurobiology of pregnancy that we don't understand yet,…” Jacobs said. “关于怀孕的神经生物学，我们还不了解很多，……”雅各布斯说。 She added that this is not because women and pregnancy are too complex. More is not known about pregnancy and the brain, she said, because “biomedical sciences have historically ignored women's health.” 她补充说，这并不是因为女性和怀孕太复杂。她说，关于怀孕和大脑的情况还不清楚，因为“生物医学历来忽视女性的健康。”

In this episode of Fail Faster podcast, we welcome Catherine Winfield - VP Experience Design at Autodesk. With 15+ years of experience in design and product, she has shaped, built, and launched products in healthcare, education, and consumer services at organizations like Foundation Medicine, the Chan Zuckerberg Initiative, Hinge Health and others. With a values-aligned leadership style, she seeks to create psychologically safe environments that inspire teams to take big bets and thrive in meaningful careers.

Welcome to 2050—where we still don't have flying cars, but we're finally getting our hiring practices right. Host Ken is joined by the formidable Lisa Gable, former Presidential appointee, U.S. Ambassador, UN Delegate, and advisor to Fortune 500 companies. Lisa is here to shake up your future and maybe your present, too. With her wealth of experience at the highest levels of government and business, Lisa predicts a world where degrees collect dust and skills steal the show, where AI is the superhero women need to get back into the game, and where universities might want to start updating their résumés. They also dive headfirst into the messy stuff—workplace conflicts, mental health, and the quest for diverse leadership. Tune in if you're ready to trade in the status quo for something a little more exciting—like a workplace where passion trumps paychecks, and every generation can finally play nice. BONUS: Elevate your hiring game with our comprehensive playbook on skill-based hiring - a practical guide designed to help you modernize your strategies, tap into diverse talent, reduce hiring biases, and build teams ready to tackle today's challenges and tomorrow's disruptions. Download it here:  https://turningpointexecsearch.com/succession-planning-checklist-2/ Ready to overhaul your approach?  Have questions or personal experiences? Drop us a message or Join the conversation on LinkedIn.—share your own succession planning horror stories and tips. Don't miss out—subscribe now and share this episode with your network! Hiring matters — mess it up! Key Takeaways: Skills Over Degrees: Lisa Gable predicts a future where skills will matter more than degrees, prompting a potential market correction in the university system. AI Empowerment: AI is seen as a crucial tool in helping women reenter the workforce, offering new opportunities and support. Workplace Challenges: Addressing conflicts, mental health, and transparency are vital for building a healthy and engaged workforce. Diverse Leadership: The discussion highlights the importance of breaking down barriers to achieve true diversity in leadership roles. Intergenerational Collaboration: A focus on collaboration across generations is key to fostering a dynamic and inclusive workplace. Passion vs. Paychecks: Encouraging employees to follow their passion rather than chasing a paycheck is essential for long-term success and satisfaction. About Our Guest: Lisa Gable is the WSJ and USA Today bestselling and award-winning author of the book, Turnaround: How to Change Course When Things are Going South and is recognized worldwide as a turnaround mastermind. As CEO of several organizations, and as a former Presidential appointee, US Ambassador, UN Delegate, and advisor to Fortune 500 companies, Lisa has orchestrated and executed the successful turnarounds of well-known private and public organizations. She is highly regarded in business, political, and philanthropic circles for her ability to tackle difficult issues directly and with discipline and diplomacy. Lisa is the Chairperson of World in 2050, the futuristic think tank of the Diplomatic Courier Global Affairs Media Network and a Distinguished Fellow at the Hunt Institute for Engineering and Humanity, at SMU Lyle School of Engineering in Dallas, Texas.  Most recently Lisa served as the CEO of FARE, the world's largest funder of food allergy research where she secured $100M in commitments over 3 years. Prior to leading FARE, she was a senior advisor at PepsiCo and President of the Healthy Weight Commitment Foundation, a CEO-driven national initiative aimed at helping to reduce obesity. In 2004, she was appointed by President George W. Bush as US Ambassador and Commissioner General to the 2005 Aichi World EXPO. Gable is the first woman in World's Fair's 170-year history to direct the U.S. Pavilion, a 100 percent non-federally funded $33.7 million operation. Lisa was named one of the 10 Most Influential Business Leaders in 2022 by CXO Magazine. An entrepreneur and mentor, Lisa acts deliberately to move organizations and individuals toward their full potential. In the past, she served as the founding chair of the board of directors for the Foundation for a Smoke-Free World; has been a national trustee of the Boys and Girls Club of America and on the board of directors of Girls Scouts of the USA; a board of trustee of Thunderbird School of Management; a member of the National Academy of Medicine IOM Roundtable on Obesity Solutions; and board member of the Independent Women's Forum. She is also a mentor in organizations such as Rare as One project, a Chan Zuckerberg Initiative and serves on the advisory boards of startups in the health and wellness space. About Your Host: Ken Schmitt is the CEO and founder of TurningPoint Executive Search. He is also the author of "The Practical Optimist: An Entrepreneur's Journey through Life's Turning Points". Ken was raised in an entrepreneurial family and brings a uniquely authentic voice to his podcast, blending life, family, and business together. Ken is a seasoned expert with almost three decades of experience in executive recruiting. In his podcast, he focuses on revealing the secrets of recruiting, retention, and real HR strategies. The podcast is not preachy, academic, or theoretical. It provides authentic perspectives on the challenges, triumphs, and quirks that make the hiring game both exhilarating and unpredictable. Twice a month, Ken offers tactical advice and industry insights to empower listeners to navigate the intricate world of executive recruiting confidently. "Hiring Matters" is your go-to resource for elevating your hiring game and equipping you with the tools to build, grow, and lead truly exceptional teams. Brace yourself for Ken's "Recruiter Rant" episodes, where he shares unfiltered insights and behind-the-scenes revelations about the industry's hidden secrets. Get ready to gain more than expected from this informative and engaging podcast. Follow Ken on LinkedIn Powered by TurningPoint Executive Search: Helping business hire right.

Allison Wolff is CEO of Vibrant Planet PBC which builds platforms that help build community and landscape resilience in the face of climate change and wildfire. After building the Netflix brand and digital experience, Allison advised corporate and nonprofit leadership teams on vision, strategy, and social and environmental innovation. Clients include Google, eBay, Facebook, Chan Zuckerberg Initiative, Omidyar Network, Patagonia, Nike, HP, Drawdown, Conservation International, and GlobalGiving. She is now leveraging her experience and network to develop solutions for forest and landscape resilience and carbon drawdown.

Stan Rapp is a Ukrainian product designer who currently resides in the US. With 15 years of experience in design, including a decade in design leadership roles, Stan is currently leading a mission-critical design team at Asana. Before Asana, Stan scaled design teams at the Chan Zuckerberg Initiative and Ford. Stan has won multiple design awards, including SF Design Week, TechCrunch Disrupt, Red Dot, and Innovation by Design from FastCompany. In this eye-opening episode of Nodes of Design, we dive deep into the world of workplace dynamics with Stan Rapp, a Ukrainian product designer leading mission-critical teams at Asana. With 15 years of experience and a track record of scaling design teams at major organizations, Stan offers invaluable insights on navigating power and politics at work. Discover: Strategies for effective conflict resolution Tips for navigating office politics while maintaining integrity Real-life stories of power dynamics in action The impact of company structure on team dynamics Future trends in workplace power structures with the rise of hybrid work and AI Whether you're a design professional, team leader, or anyone looking to advance their career, Stan's practical advice and personal experiences will equip you with the tools to thrive in today's complex work environments. Don't miss this candid discussion on the often unspoken realities of professional life. Get a Copy of the Nodes of Wisdom: Lesson from 100 Creative Visionaries on Amazon - https://amzn.in/d/02yZPlUj Thank you for listening to this episode of Nodes of Design. We hope you enjoy the Nodes of Design Podcast on your favorite podcast platforms- Apple Podcast, Spotify, Google Podcasts, Amazon Music, and many more. If this episode helped you understand and learn something new, please share and join the knowledge-sharing community Spreadknowledge. This podcast aims to make design education accessible to all. Nodes of Design is a non-profit and self-sponsored initiative by Tejj.

Our 250th podcast was recorded LIVE July 11, 2024 at the Chan Zuckerberg Initiative in Redwood City, Ca during OPENING DAY of our 6th ANNUAL FILM FEST. The podcast was recorded/streamed live by Pen Media with BraveMaker founder/executive director Tony Gapastione and actor/producer Priscilla Lam hosting special guests from the BraveMaker Film Fest (VIP Impact Honorees): LAUREN WELLS Screenwriter on "WHAT WE DO IN THE SHADOWS" and creator of "Mina and Lucy's Guide to Killing Dracula." (podcast). AVRIL SPEAKS Showrunner/Director of Netflix's "Files of the Unexplained" and host of Distribution Advocates presents podcast. KEN WHITTINGHAM Director for decades on such TV shows as: "The Office," "Parks and Recs," "Abbott Elementary," "Good Girls," "Black-ish," "The Upshaws" and more! LEAH KNAUER Actress, Comedian/Impressionist and Social Media Influencer NADINE CROCKER Actor/Writer/Director/Producer of films: "Continue" and "Desperation Road." OLIVIA ALLEN Actress, Producer and podcaster of: Broad Ideas with Rachel Bilson --- Support this podcast: https://podcasters.spotify.com/pod/show/bravemaker/support

“You can't be independent if you're not deeply connected. So what happens to a child that's not deeply connected? What actually happens? Guess what happens? They don't feel the confidence to be able to take risks. They don't feel the confidence to go out and be self-sufficient. They don't feel the confidence in doing it. So we're actually backbiting, right? We're kicking ourselves in the asses when we just focus on independence. Because we need to give them the skills to be able to be independent, which are relational skills, which is knowing that when I need help, I can turn to you and you will help me and I will help you when you need it. So then you can go off and take a risk or go and live in a new city or go have your own apartment and know that you can lean on me when you need to. And so to me, the attachment story that comes out, at this point, almost a century of research on attachment is a gorgeous, gorgeous story.” So says Dr. Niobe Way, an internationally-recognized Professor of Developmental Psychology, the founder of the Project for the Advancement of Our Common Humanity (PACH) at NYU, and the Director of the Science of Human Connection Lab. She is also a Principal Investigator of the Listening Project, funded by the Spencer Foundation, the Chan-Zuckerberg Initiative and the Rockefeller Foundation. When she was a student, Niobe studied with Carol Gilligan—if you read my newsletter or listen to this podcast, you know Carol is a hero of mine and will be wrapping up this series as a guest. Niobe has done for boys what Carol has done for girls—and their research intersects and Venn diagrams in fascinating ways. While Carol's research shows that girls come to not know what they know, Niobe traces how boys disconnect from their caring and often enter a period of irrevocably devastating and dangerous loneliness. Niobe is the author of Deep Secrets: Boys' Friendships and the Crisis of Connection as well as the just-released, Rebels with a Cause: Reimagining Boys, Ourselves, and Our Culture, which offers fascinating insight into our culture at large. Along with historical context, Niobe offers beautiful case studies from her research—following and interviewing boys as they grow up—along with notes from boys who have gone on to wreak havoc on the culture, in homicidal and suicidal ways. These notes speak to disconnection, extreme loneliness, and feeling like nobody cares. As I talk about my book in living rooms around the country, I often cite Niobe and Carol Gilligan, specifically the insight that at a certain point—around 8 for boys, and 11 for girls—the word “don't” enters children's vocabulary. For girls, it's “I don't know.” For boys, it's “I don't care.” And of course, girls knows. And of course, boys care. We need to repair our culture so it's safe for them to stay connected. As you can tell, I'm very excited for this conversation. MORE FROM NIOBE WAY, PhD: Rebels with a Cause: Reimagining Boys, Ourselves, and Our Culture Deep Secrets: Boys' Friendships and the Crisis of Connection The Crisis of Connection: Roots, Consequences, and Solutions Niobe Way's Website To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Today's guest is Jessica Rolph, cofounder and CEO of Lovevery, a subscription brand that sells early-childhood development play kits and solutions. To date, Jessica has raised over $132 million for Lovevery from top-tier investors, including, TCG, Google Ventures, Collaborative Fund, and the Chan Zuckerberg Initiative. Lovevery has 350,000+ active subscribers. It has been named one of Fast Company's “World's Most Innovative Companies" and has been recognized on TIME's list of "Best Inventions". Prior to Lovevery, Jessica was the cofounder and COO of Happy Family, helping to launch, build and lead Happy Family to its position as a top organic baby and toddler brand in the US. Happy Family was acquired by Group Danone in 2013 for about $300 million. Jessica also co-founded the Climate Collaborative , a non-profit organization helping companies in the natural products industry take meaningful steps to reverse climate change. She is an Aspen Institute Henry Crown Fellow and was awarded the Park Leadership Fellowship.  In this episode, we dive into: Jessica opens up about how she never thought of herself as an idea person when it came to starting a business How she found purpose in life and how she discovered a market for Happy Family and Lovevery How to find product market fit Why ugly prototypes are the way to go Exiting to Danone and dreaming about Lovevery Her fundraising experience and how she deals with rejection Delegation versus what to control as a leader

In this engaging episode of BIO from the BAYOU, host James Zanewicz, JD, LLM, RTTP, sits down with Marc Malandro, PhD, to explore the impactful work of the Chan Zuckerberg Initiative (CZI). Founded in 2015, CZI initially broadly aims to tackle some of society's most pressing challenges to create a more inclusive, just, and healthy future. Having announced a next-phase on being a science-forward organization in January of 2024, Malandro is an increasingly key figure in CZI's ongoing initiatives (at the time of the interview as VP of Science Operations and now serving as Chief Operating Officer for the entire organization). Malandro also delves into the BioHub Network, which empowers scientists to pursue bold, high-risk ideas, and emphasizes the crucial role of collaboration in driving scientific progress. This episode was recorded at Bio on the Bayou, an annual event in New Orleans that highlights academic science, biotech innovations, and startups from the Gulf South region.

Con el objetivo de formar jóvenes hispanos competitivos en el nuevo mercado laboral tecnológico, millones de personas se preparan para asumir un futuro donde las máquinas inteligentes, serán un apoyo en la asistencia médica, la industria y el hogar.

Ana Zamora is the Founder and CEO of The Just Trust – a nonprofit organization that supports criminal justice reform and public safety innovation in the United States. This week, we're sharing a conversation that Ana had with host Charlotte Alter in March, in which she shares her personal journey into criminal justice reform, spurred by her brother's experience with the system. The pair delve into the complexities and necessities of bipartisan collaboration in criminal justice reform, discussing how Democrats and Republicans can work together to create meaningful change. They explore the critical role of philanthropic investment in effecting positive change and the innovative strategies in use at The Just Trust and its partner organizations, and the importance of police and community cooperation in solving difficult issues. With insights from her background at the ACLU and the Chan Zuckerberg Initiative, Ana provides a compelling vision for a more just and equitable future and the investment strategy she believes it will take to get there.See omnystudio.com/listener for privacy information.

Un revolucionario de las redes sociales. Una de las personas más ricas del mundo. Un mercader de datos personales. Una mente brillante de los negocios tecnológicos. Un filántropo. Un hombre con “sangre en las manos”, al decir de un legislador estadounidense. Todo eso es Mark Zuckerberg. El fundador de Facebook cumplió 40 años ayer, y los cumpleaños redondos son para todos un momento para pasar raya. Zuckerberg es el accionista controlador de la compañía madre de Facebook, Meta Plataforms, que engloba también a Whatsapp, Instagram y la empresa de realidad virtual Oculus. Es uno de los dueños de la Chan Zuckerberg Initiative, organización considerada “filantrocapitalista” que creó junto con su esposa Priscila Chan y con la que pretenden terminar con las enfermedades y lograr cambios de fondo en la educación mundial. Es rutinariamente señalado como uno de los responsables de movimientos tectónicos en la realidad de los medios de comunicación, de la privacidad online y hasta de la salud de la democracia, para bien y para mal. Conversamos sobre cuáles son los efectos de Zuckerberg en nuestro espacio de Disrupción, Tecnología e Innovación.

EDUCATING THE IMMUNE RESPONSE. Andrea Califano is President of the Chan Zuckerberg Biohub New York. He is the Clyde and Helen Wu Professor of Chemical and Systems Biology at Columbia University Irving Medical Center, and also holds appointments in the Departments of Biochemistry & Molecular Biophysics, Biomedical Informatics, and Medicine. The Chan Zuckerberg Biohub Network of scientific institutes is supported by and partners with the Chan Zuckerberg Initiative to help researchers cure, prevent, or manage all diseases by the end of the century. “We are trying to take over where natural evolution has stopped.” “We need to learn more about mechanisms that we can harness to generate universal therapies.” “For Alzheimer's and Parkinson's, we are certainly hoping to accomplish being able to detect them at a stage where they are still treatable.”

On this week's Tech Nation, Moira speaks with Pulitzer-Prize winning author, Ed Humes, talks about his book, “Total Garbage… How We Can Fix Our Waste and Heal Our World.” Then, Dr. Steve Quake, Head of Science at the Chan Zuckerberg Initiative tells us about their ambitious goal to address all human diseases within the next century.

Guest Yani Bellini Saibene Panelist Richard Littauer Show Notes In this episode of Sustain, host Richard welcomes guest Yani Bellini Saibene from Argentina. Yani, with a rich background in open source community management, shares her journey into the tech and open source world, and highlights her roles as the rOpenSci Community Manager, R-Ladies Project Lead, and Vice President for the Board of Directors for The Carpentries. The discussion dives into the challenges of funding, sustainability of volunteer-based models, and the importance of including diverse voices in open source development. The conversation also explores the economic disparities and cultural differences affecting contributors form the global south and how building strong local communities can empower individuals by providing them with tools, knowledge, and a sense of belonging in the wider world. Press download to hear more! [00:01:47] Yani describes her start as a researcher at INTA while at university, her degree in computer science, and her initial work developing software and teaching scientists to use computing tools. She also details her career progression and her master thesis at INTA. [00:04:49] We hear about the foundation and global expansion of R-Ladies, as Yani emphasizes community strength and the organizers' passion. She discusses the flexibility and inclusivity of the chapters, and the support and resources shared among the community. [00:08:56] Richard questions about the distinct roles and activities between rOpenSci, R-Ladies, and The Carpentries, which appear to have similar goals in teaching R, and Yani explains the different objectives of the three organizations. [00:12:50] Yani lists the funders, including the Chan Zuckerberg Initiative, Sloan Foundation, and others. She describes the funding models for R-Ladies and Carpentries and the challenges of sustaining such community-oriented projects. [00:14:52] Richard inquires about the role of the board of directors in establishing post-grant funding. Yani explains The Carpentries' membership model where institutions pay for benefits like workshops and instructor training, she mentions the perks for members, discusses the challenges of maintaining services without sufficient membership or grants, and highlights cultural and financial barriers in Latin America. [00:20:17] Richard is curious about cultural barriers and asks for further insights into overcoming cultural barriers and the limitations of translations. Yani discusses her personal journey with the English language and its importance in coding beyond syntax and shares some data from a recent study that was done, and the paper is called, “The manifold costs of being a non-native English speaker in science,” from PLOS Biology. [00:24:42] Yani discusses additional studies, mentioning the Linux Foundation report on English as a barrier in open source contribution and its influence on perceived expertise. [00:25:55] Richard asks Yani about the point at which translation efforts start to yield benefits for the community and inquires about the visible impacts and dividends from investments in internationalizing materials. Yani cites examples of immediate benefits, and discusses her involvement in translating educational materials, which has supported teaching many Spanish speaking teachers. [00:32:38] Richard raises concerns about the possibility of global exploitation through talent extraction from non-English speaking regions. Yani addresses the issue of local versus international business compensation and the ethical implications for non-profit organizations. [00:36:30] We hear Richard's concerns about how to have conversations about open source contributions and community building in a non-extractive way and he wonders if it's feasible to collectively support open source maintainers financially. Yani explains the concept of three “currencies” in any job: money, heart, and brain. [00:39:16] Yani discusses the champions program at rOpenSci, where stipends were important for participants to allocate time to the tasks and do an excellent job. [00:41:05] Find out where you can follow Yani online. Quotes [00:06:17] “In R-Ladies, you have enough informality and enough expertise to make this a special place to learn.” [00:18:26] “There is little funding for maintaining what you already have.” [00:20:40] “I have to confess that I approached the English language because I loved code.” Spotlight [00:42:26] Richard's spotlight is a book he's reading called, Theodore Rex. [00:43:10] Yani's spotlight is a friend and someone she works with at R-Ladies, Athanasia Mo Mowinckel. Links SustainOSS (https://sustainoss.org/) SustainOSS Twitter (https://twitter.com/SustainOSS?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor) SustainOSS Discourse (https://discourse.sustainoss.org/) podcast@sustainoss.org (mailto:podcast@sustainoss.org) SustainOSS Mastodon (https://mastodon.social/tags/sustainoss) Open Collective-SustainOSS (Contribute) (https://opencollective.com/sustainoss) Richard Littauer Socials (https://www.burntfen.com/2023-05-30/socials) Yani Bellini Saibene GitHub (https://github.com/yabellini) Yani Bellini Saibene Mastodon (https://fosstodon.org/@yabellini) Yani Bellini Saibene Website (https://yabellini.netlify.app/) Yani Bellini Saibene LinkedIn (https://www.linkedin.com/in/yabellini/) Teaching Tech Together (https://teachtogether.tech/) R-Ladies (https://rladies.org/) The Carpentries (https://carpentries.org/index.html) rOpenSci (https://ropensci.org/) The manifold costs of being a non-native English speaker in science (PLOS Biology) (https://doi.org/10.1371/journal.pbio.3002184) Chan Zuckerberg Initiative (https://chanzuckerberg.com/) Sloan Foundation (https://sloan.org/) Drive: The Surprising Truth About What Motivates Us by Daniel H. Pink (https://www.danpink.com/books/drive/) Theodore Rex by Edmund Morris (https://en.wikipedia.org/wiki/Theodore_Rex_(book)) Dr. Athanasia Mo Mowinckel (https://drmowinckels.io/) Credits Produced by Richard Littauer (https://www.burntfen.com/) Edited by Paul M. Bahr at Peachtree Sound (https://www.peachtreesound.com/) Show notes by DeAnn Bahr Peachtree Sound (https://www.peachtreesound.com/) Special Guest: Yani Bellini Saibene.

Global Product Management Talk is pleased to bring you the next episode of... Product Mastery Now with host Chad McAllister, PhD. The podcast is all about helping people involved in innovation and managing products become more successful, grow their careers, and STANDOUT from their peers. About the Episode:  Today we are talking about how product leaders can create more effective teams by using a people-first leadership approach. Joining us is Diana Stepner, Head of Product for Educations at the Chan Zuckerberg Initiative. Her approach to product leadership empowers individuals, fosters collaboration, and connects with people in an authentic way. She is also a product leadership instructor on Maven and has held leadership and advisor product positions.

Join our host André Marquet in a conversation with Diana Stepner, a product leader with a strong background in tech, business, and UX, known for driving innovation and team growth in D2C, SaaS, and digital transformation. She's led key programs like SimplePractice and the Catalyst Startup Accelerator, excelling in team collaboration and mentorship. Her work spans across industries, marking her as a notable figure in product innovation.

There are countless barriers facing immigrant communities when it comes to finding success and economic security in the US. Today we hear from two women who are working tirelessly to level the playing field by reimagining capitalism. Lemonada's Hoja Lopez chats with Ruby Bolaria Shifrin, head of community at the Chan Zuckerberg Initiative, and Claudia Arroyo, executive director of the non-profit Prospera. They discuss the value of supporting latinx entrepreneurs and putting female-owned businesses at the forefront of their local economies. This episode is supported by the Chan Zuckerberg Initiative. The Chan Zuckerberg Initiative was founded in 2015 to help solve some of society's toughest challenges — from eradicating disease and improving education, to addressing the needs of our local communities. CZI's mission is to build a more inclusive, just, and healthy future for everyone. To learn more, visit https://chanzuckerberg.com. Thank you to Prospera for joining this conversation. Prospera advances Latina economic empowerment through leadership development, entrepreneurship and cooperative business ownership. Prospera believes that when women are at the forefront of our local economies, entire communities thrive. To learn more and get involved, visit https://prosperacoops.org.See omnystudio.com/listener for privacy information.

What's the root cause of poverty in America? And how do we fix it? In this discussion, Matthew Desmond, renowned Princeton sociologist and author of "Poverty, by America," talks about why poverty persists in the U.S. with Marc-Andreas Muendler, economic professor at UC San Diego. Desmond argues we can end poverty through grassroots activism and a willingness to target systems that perpetuate it, like local zoning laws. Desmond was catapulted into the national spotlight as a leading authority on modern American poverty when his Pulitzer Prize-winning masterpiece, “Evicted: Poverty and Profit in the American City,” made its debut in 2016. His work has been supported by the Gates, Horowitz, Ford, JBP, MacArthur, and National Science, Russell Sage, and W.T. Grant Foundations, as well as the Chan Zuckerberg Initiative. Series: "Helen Edison Lecture Series" [Public Affairs] [Business] [Show ID: 39385]

What's the root cause of poverty in America? And how do we fix it? In this discussion, Matthew Desmond, renowned Princeton sociologist and author of "Poverty, by America," talks about why poverty persists in the U.S. with Marc-Andreas Muendler, economic professor at UC San Diego. Desmond argues we can end poverty through grassroots activism and a willingness to target systems that perpetuate it, like local zoning laws. Desmond was catapulted into the national spotlight as a leading authority on modern American poverty when his Pulitzer Prize-winning masterpiece, “Evicted: Poverty and Profit in the American City,” made its debut in 2016. His work has been supported by the Gates, Horowitz, Ford, JBP, MacArthur, and National Science, Russell Sage, and W.T. Grant Foundations, as well as the Chan Zuckerberg Initiative. Series: "Helen Edison Lecture Series" [Public Affairs] [Business] [Show ID: 39385]

What if AI could tell us we have cancer before we show a single symptom? Steve Quake, head of science at the Chan Zuckerberg Initiative, explains how AI can revolutionize science. AI can help us understand complex systems like our cells. better. The Chan Zuckerberg Initiative is committed to building one of the world's biggest non-profit life science AI computing clusters to help build digital models of what goes wrong in cells when we get diseases like diabetes or cancer and more. We created this video in partnership with the Chan Zuckerberg Initiative. ---------------------------------------------------------------------------------- About Steve Quake: Steve Quake oversees a shared, comprehensive strategy across the CZ Science program and technology teams, the CZ Biohub Network, and the Chan Zuckerberg Institute for Advanced Biological Imaging. His research is at the nexus of biology, physics, and technology development. He has invented many measurement tools for biology, including new DNA sequencing technologies that have enabled rapid analysis of the human genome, and microfluidic automation that allows scientists to efficiently isolate cells for single-cell biology. Quake is also the Lee Otterson Professor of Bioengineering and professor of applied physics at Stanford University. He joined Stanford in 2005 to help found and lead Stanford's then-new bioengineering department as it grew to nearly two dozen faculty members. He was an Investigator at the Howard Hughes Medical Institute from 2006 to 2016. Learn more about your ad choices. Visit megaphone.fm/adchoices

Join us for our conversation with Diana Stepner, Head of Product at the Chan Zuckerberg Initiative. Diana shares a refreshing reminder that putting people at the heart of product management isn't just nice to have; it's essential. As Diana unfolds her journey from user experience research to leading product innovation, she champions a transformative approach that empowers individuals, fosters collaboration, and resonates deeply on a human level. Featured Links: Follow Diana on LinkedIn | Diana's website | Try Diana's 'People-First Product Leadership' course at Maven | Diana's profile at SubstackOur HostsLily Smith enjoys working as a consultant product manager with early-stage and growing startups and as a mentor to other product managers. She's currently Chief Product Officer at BBC Maestro, and has spent 13 years in the tech industry working with startups in the SaaS and mobile space. She's worked on a diverse range of products – leading the product teams through discovery, prototyping, testing and delivery. Lily also founded ProductTank Bristol and runs ProductCamp in Bristol and Bath. Randy Silver is a Leadership & Product Coach and Consultant. He gets teams unstuck, helping you to supercharge your results. Randy's held interim CPO and Leadership roles at scale-ups and SMEs, advised start-ups, and been Head of Product at HSBC and Sainsbury's. He participated in Silicon Valley Product Group's Coaching the Coaches forum, and speaks frequently at conferences and events. You can join one of communities he runs for CPOs (CPO Circles), Product Managers (Product In the {A}ether) and Product Coaches. He's the author of What Do We Do Now? A Product Manager's Guide to Strategy in the Time of COVID-19. A recovering music journalist and editor, Randy also launched Amazon's music stores in the US & UK.

Meet Stan Rapp, a name in the design world who transitioned from being a self-taught designer to leading Enterprise Design at Asana. Before his current role, Stan shaped product design at the Chan Zuckerberg Initiative. On top of his design expertise, he's a certified coach and a recent graduate of UPenn's Executive Design Leadership program. Specializing in design strategy and co-creation, he's particularly interested in designing for emotions and behavior change. A native of Ukraine, now residing in the SF Bay Area, Stan has shared his insights at several notable conferences, including The Next Web and Adobe. He has also won awards from SF Design Week and TechCrunch Disrupt.

The Chan Zuckerberg Initiative (CZI) was founded in 2015 to help solve society's challenges and create an inclusive, just, and healthy future. Dr. Marc Malandro discusses his role within CZI's science initiative, and their mantras of "Build, Fund, and Do." He also explains the BioHub Network, which empowers scientists to pursue exciting ideas regardless of the risk, and the role collaboration plays in their ability to propel science forward. Episode hosted by James Zanewicz. This episode was recorded at BIO on the BAYOU, the annual symposium in New Orleans showcasing academic science, biotech, and startups from the entire Gulf South region.

Episode Description: Dive into a riveting exploration of the intricate dance between science, art, and the animal microbiome. Aaron Schacht delves deep into the transformative power of the microbiome in shaping animal health, the innovative strides in drug development, and the mesmerizing blend of genetics and artistry. From the challenges in livestock production to the silent symphony of cells at a genetic rave, join us on a journey that promises to redefine your understanding of biology and creativity. Grow Everything brings to life the bioeconomy when hosts Karl Schmieder and Erum Azeez Khan share stories from the field and interview leaders and influencers in the space.  Life is a powerful force and it can be engineered. What are we creating? Learn more at www.messaginglab.com/groweverything Topics Covered: 00:00:00 - Delving into a World of Art and Biology: Biotech Beginnings 00:05:47 - Merging Education and Creativity: Enhancing Learning through Art 00:07:03 - Efficiency in Biotechnology: Maximizing Outcomes and Value 00:11:08 - Digital Advancements: Meta's Exploration of Cellular Models 00:14:49 - Big Moves in Biomed: Ginkgo-Pfizer and Merck-Daiichi Collaborations 00:18:24 - Unveiling Animal Health: A Rich Resource in Biomedical Research 00:20:02 - A Warm Welcome to the World of Animal Biomedicine 00:25:21 - Pioneering Drug Safety: The Role of Animal Models 00:30:41 - Sustainable Antibiotic Practices in Animal Farming 00:35:41 - Navigating Challenges: Bacterial Solutions and Microbiomes 00:39:55 - Bridging Academia and Industry: Productive Biotech Innovations 00:42:57 - Advancements in Livestock Health: Probiotics and Enzymes 00:45:44 - Introducing New Biological Therapeutics: Navigating USDA Regulations 00:49:23 - Crafting a Progressive Ecosystem: Investing in Animal Health 00:55:43 - Visioning the Future: Merging Animal Health with Financial Sustainability 00:59:21 - The Digital Leap: AI and Microbiome Engineering in Biomedicine 01:03:16 - Flavor Profiles: Unpacking the Animal Microbiome's Influence 01:07:18 - Collaboration in Biotech: Engaging in Thoughtful Panel Discussions Episode Links: LinkedIn Music Genome Project BiomEdit (company site) Depeche Mode (band site) Ed Ruscha (artist site) Chan Zuckerberg Initiative (organization site) Headway (company site) Gingko & Pfizer deal (story site) Merck & Daiichi Sankyo (story site) Gingko & Persephone collaboration (story site) BioCortex - understanding drug-microbiome interactions (company site) Culitvarium - domesticating non-model organisms (company site) Have a question or comment? Message us here: Text or Call (804) 505-5553 Instagram / TikTok / Twitter / LinkedIn / Youtube / GrowEverything website Email: groweverything@messaginglab.com Support here: Patreon Music by: Nihilore Production by: Amplafy Media --- Send in a voice message: https://podcasters.spotify.com/pod/show/messaginglab/message

The organization led by Priscilla Chan and Mark Zuckerberg will work with Columbia, Rockefeller and Yale to study immune cells.

Neuralink opens enrollment for its first human BCI implants, and The Chan Zuckerberg Initiative is building a massive GPU cluster to ‘cure, prevent or manage all diseases'. Learn more about your ad choices. Visit megaphone.fm/adchoices

Are you feeling like life's treadmill has you sprinting toward burnout?  In this episode, we delve into topics that are often ignored, yet are integral to achieving not just success, but a well-rounded, fulfilling life. We'll explore how physical and mental health are closely linked, and why ignoring one can spell disaster for the other. We'll dissect the importance of pacing yourself, even when ambition courses through your veins. We'll talk about why it's crucial to interrogate your choices and how a sudden jolt—changing your environment or habits—can propel you out of unhealthy patterns.After this Episode, You Will Be Able to:Master your physical and mental well-beingSeize control of your timeAchieve a well-rounded, fulfilling lifeFree Resources: Thank you for taking the time to write a review and for sharing the podcast with your friends. To claim your free resources send a screenshot of your review to UnstoppableGritPodcast@DanielleCobo.com. We appreciate your support!Want to work with Danielle? Schedule your call today: https://bit.ly/3OnuLLOLet's Connect!LinkedIn: https://www.linkedin.com/in/daniellecobo/Facebook: https://www.facebook.com/MsDanielleCoboInstagram: https://www.instagram.com/thedaniellecobo/?hl=enTwitter: https://twitter.com/DanielleCoboWebsite: www.DanielleCobo.comJoin the Unstoppable Grit Podcast Facebook Community: www.facebook.com/groups/unstoppablegritpodcastcommunity/Book Recommendations:  https://www.amazon.com/shop/influencer-de49157c/list/2W8I8NWS6N4CJAbout the guestDr. Yasmene Mumby is a sustainable leadership advisor and writer.Purpose-driven teams invite Dr. Mumby and her firm, The Ringgold, to consult and collaborate on their mission-critical organizational ambitions.She weaves in her framework, The Easeful Leader, for high-performing leaders who are looking to reclaim their time, lead with ease, and build better teams. She combines her background in academia and wellness to coach ambitious high-level executives, leaders, and business owners to move away from burn out and exhaustion towards sustainable leadership for themselves and the teams they lead.She's worked with some of the most impactful organizations in the country and world including, the ACLU, The International Rescue Committee, Harvard Radcliffe Institute, Chan Zuckerberg Initiative, National Audubon Society, Faith in Action, and Working Families Party.Her work and commentary on leadership and wellbeing have appeared in various publications including Entrepreneur, CNBC, Fortune, Essence, Black Enterprise, Yahoo Finance, and Poosh.A graduate of the McDonogh School, Yasmene earned her Bachelor's in International Studies and Master's in Teaching from The Johns Hopkins University, along with a JD from University of Maryland School of Law and a Doctorate in Education Leadership from the Harvard Graduate School of Education. Besides that, she's also completed over 1500 hours of training in vinyasa, meditation, yin, and prenatal yoga and teaches with HealHaus and Ompractice.Connect with Yasmene:LinkedIn Page Link: https://www.linkedin.com/in/yasmeneInstagram Page Link: @‌yasmene_Website: Dr. Yasmene Mumby - Writer | Leadership Adviso

Laura Splan is a transdisciplinary artist working at the intersections of science, technology, and culture. She creates conceptually layered and carefully crafted artworks that explore the sublime complexity of the biological world while unraveling entanglements of natural and built systems. Her research-driven projects connect hidden artifacts of biotechnology to everyday lives through embodied interactions and sensory experiences. Recent exhibitions have included immersive installations, networked devices, and tactile sculptures. Splan often engages audiences with themes in her work through companion programming, including participatory workshops covering laboratory techniques, specialized software, and textiles methods that she uses in her own studio practice. Her artworks exploring biomedical imaginaries have been commissioned by the Centers for Disease Control Foundation and the Bruges Triennial. Her work has been exhibited at the Museum of Arts & Design, Pioneer Works, and New York Hall of Science and is represented in the collections of the Thoma Art Foundation, the Chan Zuckerberg Initiative, NYU's Langone Art Collection, and the Berkeley Art Museum. Reviews and articles including her work have appeared in The New York Times, Wired, Discover, designboom, American Craft, and Frieze. Splan's research and residencies have been supported by the Jerome Foundation, Institute for Electronic Arts, Harvestworks, the Knight Foundation, and the Pollock-Krasner Foundation. In this episode, Laura and I discuss where art and science meet, Sticky settings in software and DNA, the relationship between learning and teaching, the presence of sound, early memories of where her art practice began and where it stands now. --- Support this podcast: https://podcasters.spotify.com/pod/show/ongoingness/support

RARE MAMAS RISING- EPISODE 28 A Moving Mission with The Stiff Person Syndrome Research Foundation Founder and President Dr. Tara Zier   In 2017, Dr. Tara Zier, a graduate of the VCU School of Dentistry and Virginia Tech, a black belt in karate, and a mother of two, was forced to leave a twenty-year career in dentistry and stop the practice of karate due to Stiff Person Syndrome. Today, Zier is the founder and president of The Stiff Person Syndrome Research Foundation (SPSRF), which she established in 2019 to raise awareness and funds for better treatments and a cure. In 2021, The SPSRF was selected to receive a three-year “Rare As One” grant from the Chan Zuckerberg Initiative, and in 2022, Zier established a Medical Advisory Board, including neurologists from Mayo Clinic, Johns Hopkins Medicine, and others. Zier and The SPSRF have been featured in The Washington Post, Voice of America, ABC News in Washington, and various media outlets worldwide. In this episode, Dr. Zier exudes strength of purpose as she fights for treatment and better quality of life for those with Stiff Person Syndrome. She won't be still as she moves forward on her mission!       EPISODE HIGHLIGHTS All about Stiff Person Syndrome and why so many patients go through a diagnostic odyssey The Stiff Person Syndrome Research Foundation's mission and future plans How Dr. Zier juggles motherhood, running The SPSF, and being a patient How Celine Dion's Stiff Person Syndrome diagnosis elevated SPS awareness Where Dr. Zier finds hope and motivation How Dr. Zier has learned to put firm boundaries around her time and energy Dr. Zier's best advice to other rare mamas   LINKS & RESOURCES MENTIONED   The Stiff Person Syndrome Research Foundation Website: http://www.stiffperson.org/ Twitter: https://twitter.com/TheSPSRF Instagram: https://www.instagram.com/stiff_person_syndrome/ Facebook: https://www.facebook.com/TheSPSRF LinkedIn: https://www.linkedin.com/company/the-stiff-person-syndrome-research-foundation/   Chan Zuckerberg Rare As One Initiative https://chanzuckerberg.com/science/programs-resources/rare-as-one/   Celine Dion Announces Stiff Person Syndrome Diagnosis https://www.ctvnews.ca     CONNECT WITH NIKKI   Facebook https://www.facebook.com/RareMamas1/ Instagram https://www.instagram.com/Rare_Mamas/ Website https://raremamas.com/ Email info@raremamas.com  

The CZ Biohub's inspiring story began when Priscilla Chan asked Stephen Quake a seemingly impossible question: “Is it possible to cure, prevent, and manage disease in our children's lifetime?”. In 2016, the Chan Zuckerberg Initiative, founded by Priscilla and Mark Zuckerberg, set out to answer that question with a bold new mission. On the final installment of our CZ Biohub series, Priscilla and Stephen join Nate to talk about the work being done at Biohub, and how understanding human biology is the key to unlocking powerful medical treatments and cures. Through their commitment to the cause, they are showing that anything is possible. Priscilla Chan is co-founder and co-CEO of the Chan Zuckerberg Initiative (CZI). Stephen Quake is Head of Science at the Chan Zuckerberg Initiative, where he oversees CZI's science grant programs, technology development, and the CZ Biohub Network. Stephen is also a professor at Stanford University. Learn more about CZ Biohub: https://www.czbiohub.org/about/#history-amp-mission Listen to more episodes from our CZ Biohub series: https://theshowaboutscience.com/2023/02/12/099-accelerating-science-to-eradicate-disease-with-priscilla-chan-and-stephen-quake/ Connect with The Show About Science:  Instagram: https://www.instagram.com/showaboutscience Facebook: https://www.facebook.com/theshowaboutscience YouTube: https://www.youtube.com/showaboutscience Twitter: https://www.twitter.com/natepodcasts LinkedIn: https://www.linkedin.com/ Loved this episode? Leave us a review and rating wherever you listen to podcasts!

Crain's reporter Steve Daniels talks with host Amy Guth about the financial outlook for local insurance groups, specifically how State Farm posted a record $6.7 billion loss as inflation took a toll and how red ink threatens Allstate's stock-buyback plans. Plus: What's shaping up to potentially be the most divisive mayor's race in years is being fueled by both unions and executive donors, Walgreens won't sell abortion pills in 20 states after warning, developers unveil plans to turn LaSalle Street offices into apartments and Chicago lands $250 million from the Chan Zuckerberg Initiative for a biotech research hub.

Dr. Bror Saxberg is founder of LearningForge, a learning engineering consultancy that helps organizations think creatively about applying learning development and motivation science to their products, services, and strategies. Prior to this, he served as the chief learning officer and co-founder of K12 Inc., the chief learning officer of Kaplan, and the head of learning sciences at the Chan Zuckerberg Initiative. Bror is an MD PhD, giving him a rich and unique perspective on the world of learning. He focuses on applying what's known about learning science and learning measurement at scale to the practical business of making effective, efficient, usable, and graceful learning environments that get learners the outcomes they need to be successful. In this episode of the Leading Learning Podcast, Celisa talks with Bror about the components of expertise, why and when to perform a cognitive task analysis, and motivation's impact on learning. They also discuss learning engineering, effective iteration, and the importance of evidence-centered design. Full show notes and a transcript are available at https://www.leadinglearning.com/episode343. We are grateful to our sponsor for this series, WBT Systems. *** TopClass LMS provides the tools for you to become the preferred provider in your market, delivering value to learners at every stage of their working life. WBT Systems' award-winning learning system enables delivery of impactful continuing education, professional development, and certification programs. The TopClass LMS team supports learning businesses in using integrated learning technology to gain greater understanding of learners' needs and behaviors, to enhance engagement, to aid recruitment and retention, and to create and grow non-dues revenue streams. WBT Systems will work with you to truly understand your preferences, needs, and challenges to ensure that your experience with TopClass LMS is as easy and problem-free as possible. Visit leadinglearning.com/topclass to learn how to generate value and growth for your learning business and to request a demo.

At the beginning of June we were invited to moderate a panel at the Chan Zuckerberg Initiative Rare as One Annual Meeting in San Diego, CA. Most of the time diagnosis of a rare disease comes out of the blue and includes life altering, and life shortening symptoms.  The effect of which leave familiy members and friends to manage care and figure out how they might solve the problem.  Many times this means starting a nonprotit organization to advance science toward a treatment and cure.  Patients, parents and friends run these organizations with little to no budget or training.  These heroic efforts make slow progress while testing the resolve of their leaders who are constantly operating at the edge of their emotional, and physical capacity. The CZI Rare as One Program provides funding and training to build or expand research networks as well as increase organizational infrastructure to support this important work. The program started in 2019 and this was the first in person meeting of the 50 grantee organizations that make up the Rare as One Network.  It was an emotional time as the grantees continued to learn and laugh together in 3D instead of through a screen. We had the opportunity to moderate the closing session to talk about the incredible progress to date and the future of the program with three leaders of Rare as One,  Vice President, Science in Society at CZI, Tania Simoncelli Rare as One Program Manager, Heidi Bjornson-Pennell Rare as One Program Associate, Andra Stratton Enjoy the conversation.

Mark Zuckerberg — Founder and CEO of Meta | Brought to you by Eight Sleep's Pod Pro Cover sleeping solution for dynamic cooling and heating, Magic Spoon delicious low-carb cereal, and Helium 10 all-in-one software suite to sell on Amazon. More on all three below.Mark Zuckerberg (FB/IG) is the founder, chairman, and CEO of Meta, which he originally founded as Facebook in 2004. Mark is responsible for setting the overall direction and product strategy for the company. In October 2021, Facebook rebranded to Meta to reflect all of its products and services across its family of apps and a focus on developing social experiences for the metaverse—moving beyond 2D screens toward immersive experiences like augmented and virtual reality to help build the next evolution in social technology.He is also the co-founder and co-CEO of the Chan Zuckerberg Initiative with his wife Priscilla, which is leveraging technology to help solve some of the world's toughest challenges—including supporting the science and technology that will make it possible to cure, prevent, or manage all diseases by the end of the 21st century.Mark studied computer science at Harvard University before moving to Palo Alto, California in 2004.Please enjoy!This episode is brought to you by Eight Sleep! Eight Sleep's Pod Pro Cover is the easiest and fastest way to sleep at the perfect temperature. It pairs dynamic cooling and heating with biometric tracking to offer the most advanced (and user-friendly) solution on the market. Simply add the Pod Pro Cover to your current mattress and start sleeping as cool as 55°F or as hot as 110°F. It also splits your bed in half, so your partner can choose a totally different temperature.And now, my dear listeners—that's you—can get $250 off the Pod Pro Cover. Simply go to EightSleep.com/Tim or use code TIM at checkout. *This episode is also brought to you by Magic Spoon cereal! Magic Spoon is a low-carb, high-protein, and zero sugar cereal that tastes just like your favorite sugary cereal. Each serving has 13–14g of protein, 4g of net carbs, and 0g of sugar. It's also gluten free, grain free, soy free, and keto friendly. And it's delicious! It comes in your favorite, traditional cereal flavors like Cocoa, Frosted, Peanut Butter, and Blueberry.Magic Spoon cereal has received a lot of attention since their launch. Time magazine included it in their list of Best Inventions of 2019, and Forbes called it “the future of cereal.” My listeners—that's you—get $5 off and a 100% happiness guarantee when you visit MagicSpoon.com/Tim and use code TIM. And some great news for Canadian listeners: Magic Spoon now also ships to Canada!*This episode is also brought to you by Helium 10! Helium 10 is an all-in-one software suite designed to help entrepreneurs launch, manage, and scale a profitable e-commerce business on Amazon and Walmart.com. Whether you are an entrepreneur who wants to start a business on your own terms or you want to scale your existing e-commerce operations, Helium 10 is here to help. They process more than 2 billion data points daily, have a robust 450+ million ASIN database, and provide at-a-glance analytics like seasonal trends for products, profit estimates, and more.Join more than 1 million Helium 10 users worldwide by signing up for a free account at Helium10.com/Tim!*For show notes and past guests, please visit tim.blog/podcast.Sign up for Tim's email newsletter (“5-Bullet Friday”) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissFacebook: facebook.com/timferriss YouTube: youtube.com/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.